KISLip Hangover Cure

Transcription

1 KISLip Hangover Cure

2 C O N T E N T S World s First ALDH Hangover Cure

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5 Does Everybody have ALDH (Aldehyde Dehydrogenase)? Asian Flush implies that people have ALDH (Aldehyde Dehydrogenase) mutation. If you have Asian flush, you couldn t be free from alcoholic hangover.

6 Does Everybody have ALDH (Aldehyde Dehydrogenase)? 40~45% of Korean/Chinese/Japanese people have genetic mutation of ALDH which leads to improper metabolism of acetaldehyde (toxic substance of hangover) derived from Ethanol!!!

7 Livers with and without ALDH mutation It quickly decomposes both the alcohol and the acetaldehyde (a toxic substance that causes hangover) Less hangover It decomposes the alcohol, but can t decompose the acetaldehyde. Hangover and chronic tiresomeness Physiol Rev 2014:, 94: 1-34.

8 The genetic mutation of ALDH and the blood acetaldehyde concentration People with ALDH gene mutation. Even one cup of liquor can be detrimental Gene mutation of both ADH and ALDH: Even small drink can cause a high acetaldehyde concentration in the body. Only ALDH mutation : Depends on the amount of alcohol intake, blood acetaldehyde concentration changes (also not healthy). No ADH and ALDH mutation : The blood acetaldehyde concentration doesn t change much.. HUMAN GENOMICS, VOL 3. NO JAN 2009

9 Diseases caused by insufficient ALDH (Aldehyde Dehydrogenase) in the body Hangover prevention thru the metabolism of acetaldehyde

10 KISLip : Hangover Cure Candy Effective ADH & ADLH-containing Hangover Cure and Asian Flush Reliever Effects: Anti-hangover Asian Flush Cure Sober Up Elixir of Recovery

11 KISLip : Hangover Cure Candy ALDH Enzyme contained [Original Material] Fermented rice powder, Sorbitol, Sugar ester, Orange powder, Lysine Monohydrochloride, Betaine, Methionine, Vitamin C, Citric acid Decrease of blood acetaldehyde level by 60% 60% Standard KISLip 1T KISLip 2T

12 KISLip : Anti-Hangover Effect (in-vivo test) Blood ADH and ALDH Levels Comparison of 4 groups: Blue : no drinking of Ethanol Red : Ethanol intake only Green : Intake of Ethanol and 1 tablet (1100mg) of KISLip (ADH & ALDH contained) Purple : Intake of ethanol and 3 tablets (3300mg) of KISLip (ADH & ALDH contained) Test result: Meaningful decline of the concentrations of both Ethanol and Acetaldehyde in blood - 1 hour after KISLip intake.

13 This finding implies therapeutic possibility of ALDH for various kinds of human diseases, via so-called cellular detoxification and metabolism improvement. KISLip : Endogenous Aldehyde Level (in-vivo test) 0.4 Endogenous Aldehyde in Blood No Kislip Kislip Blue line is natural (endogenous) aldehyde concentration in blood. It could be dropped down even to zero concentration if 3 tablets (3,300mg) of ALDH contained product, KISLip, is taken. This could be happened at cellular level since ALDH exists within every cell.

14 Enhancement of KISLip for Hangover Cure Synergism of combination of ALDH and Glutathione-enriched Yeast for Ethanol metabolism Patent is pending by Pico Entech (application No ) Applicant (Pico Entech, Co. Ltd.) Inventors No. (YY/MM/DD) Title Blood Alcohol Concentration Blood Acetaldehyde Concentration Black: Ethanol only Green : Ethanol+KISLip Purple: Ethanol +KISLip + Glutathione Brown: Ethanol + more KISLip + Glutathione Red : Ethanol +more KISLip + Glutathione

15 KISLip: ADH & ALDH Quantitative Test (Aug )

16 KISLip Safety Data, AST/ALT The Serum Concentrations of Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) in induced acute liver injury mice model. non-liver injury liver injury control As shown above, serum AST and ALT levels in the KISLip treatment group were significantly decreased in dose-dependent manner.

17 KISLip Safety Test: microbial limit test

18 KISLip Safety Test: Heavy-metal test

19 KISLip Safety Test: ITALY Neotron Aflatoxin and insecticide contamination test

20 Globalization: Sister brands in various countries World #1

21 Partnerships in South Korea GeoYoung: Korea s the largest medicine distributor is distributing KISLip Forte to more than 5,000 drug stores in South Korea since December Bukwang Parmaceutical: A Korean Pharmaceutical Company signed on OEM production contract with Pico for their own ALDH anti-hangover. Dongwha Parmaceutical: Korea s the oldest Pharmaceutical Company also signed on OEM production contract with Pico for their own ALDH anti-hangover. Samsung Parmaceutical: Korea s well-known Pharmaceutical Company plans to produce KISLip and ALDH products for Pico Entech (Made in Korea) in 2016.

22 Pico Entech Co., Ltd. Seoul, South Korea