Alberta Human Services Drug Benefit Supplement

Transcription

1 Alberta Human Services Drug Benefit Supplement Effective April 1, 2012

2 Inquiries should be directed to: Pharmacy Services Alberta Blue Cross Street NW Edmonton, AB T5J 3C5 Telephone Number: (780) (Edmonton) (403) (Calgary) (Toll Free) FAX Number: (780) (Toll Free) Website: Administered by Alberta Blue Cross on behalf of Alberta Human Services. The Drug Benefit List (DBL) is a list of drugs for which coverage may be provided to program participants. The DBL is not intended to be, and must not be used as a diagnostic or prescribing tool. Inclusion of a drug on the DBL does not mean or imply that the drug is fit or effective for any specific purpose. Prescribing professionals must always use their professional judgment and should refer to product monographs and any applicable practice guidelines when prescribing drugs. The product monograph contains information that may be required for the safe and effective use of the product. Copies of the Alberta Human Services Drug Benefit Supplement are available from Pharmacy Services, Alberta Blue Cross at the address shown above. Binder and contents: ( G.S.T.) Contents only: ( G.S.T.) A cheque or money order must accompany the request for copies. ABC 40241/81632 (R04/2012)

3 Table of Contents PART 1 SECTION 1 POLICIES AND GUIDELINES Introduction Eligibility Additional Notes Regarding Application of the Supplement Interchangeable Drug Products Price Policy Price Policy Additional Units of Issue for Pricing Excluded Drug Products Restricted Benefits Restricted Benefits Special Authorization Guidelines Special Authorization Policy Special Authorization Procedures... 1A.1 Special Authorization Forms... 1A.2 Drug Special Authorization Request Form... 1A.4 Donepezil/Galantamine/Rivastigmine Special Authorization Request Form... 1A.6 Clopidogrel Special Authorization Request Form... 1A.8 Darbepoetin/Epoetin Special Authorization Request Form... 1A.10 Abatacept/Adalimumab/Anakinra/Etanercept/Golimumab/Infliximab/Tocilizumab for Rheumatoid Arthritis Special Authorization Request Form... 1A.13 Ezetimibe Special Authorization Request Form... 1A.15 Peginterferon Alfa-2a+Ribavirin/Peginterferon Alfa-2b+Ribavirin Special Authorization Request Form... 1A.17 Peginterferon Alfa-2a for Chronic Hepatitis C Special Authorization Request Form... 1A.19 Etanercept for Juvenile Idiopathic Arthritis Special Authorization Request Form... 1A.21 Adalimumab/Etanercept/Golimumab/Infliximab for Psoriatic Arthritis Special Authorization Request Form... 1A.23 Select Quinolones Special Authorization Request Form... 1A.25 Alendronate/Raloxifene/Risedronate/Synthetic Calcitonin Salmon Nasal Spray for Osteoporosis Special Authorization Request Form... 1A.28 Celecoxib Special Authorization Request Form... 1A.31 Filgrastim/Pegfilgrastim Special Authorization Request Form... 1A.33 Fentanyl Special Authorization Request Form... 1A.35 Adalimumab/Etanercept/Infliximab/Ustekinumab for Plaque Psoriasis Special Authorization Request Form... 1A.37 Adalimumab/Etanercept/Golimumab/Infliximab for Ankylosing Spondylitis Special Authorization Request Form... 1A.39 Adalimumab for Crohn s/ Infliximab for Crohn s/fistulizing Crohn s Disease Special Authorization Request Form... 1A.41 The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. i EFFECTIVE APRIL 1, 2012

4 Table of Contents, continued ALBERTA HUMAN SERVICES DRUG BENEFIT SUPPLEMENT RARE DISEASES DRUG COVERAGE PROGRAM Rituximab for Rheumatoid Arthritis Special Authorization Request Form... 1A.43 Imiquimod Special Authorization Request Form... 1A.45 Dutasteride/Finasteride Special Authorization Request Form... 1A.47 Paliperidone/Risperidone Prolonged Release Injection Special Authorization Request Form... 1A.49 Abatacept for Juvenile Idiopathic Arthritis Special Authorization Request Form... 1A.51 Montelukast/Zafirlukast Special Authorization Request Form... 1A.53 Febuxostat Special Authorization Request Form... 1A.55 Denosumab Special Authorization Request Form... 1A.57 Omalizumab Special Authorization Request Form... 1A.59 Eculizumab Special Authorization Request Form... 1A.61 Eculizumab Consent Form... 1A.67 SECTION 2 MULTIPLE SCLEROSIS (MS) DRUG COVERAGE Multiple Sclerosis (MS) Drug Coverage Avonex/Betaseron/Copaxone/Extavia/Rebif/Tysabri MS Drug Coverage Application Drug Products Under Multiple Sclerosis (MS) Drug Coverage Program SECTION 3 CRITERIA FOR SPECIAL AUTHORIZATION OF SELECT DRUG PRODUCTS Special Authorization Policy Criteria for Coverage SECTION 3A CRITERIA FOR OPTIONAL SPECIAL AUTHORIZATION OF SELECT DRUG PRODUCTS Criteria for Coverage... 3A Role of the Prescribers... 3A Criteria for Optional Special Authorization of Select Drug Products... 3A.1 Section 4 Rare Diseases Drug Coverage Program Rare Diseases Drug Coverage Contraindications Rare Diseases Drugs Eligible for Coverage Alberta Rare Diseases Clinical Review Panel Process for Rare Diseases Drug Coverage PART 2 Pharmacologic Therapeutic Classification of Drugs 00:00 Non-Classified Drugs :00 Pediatric Cough and Cold Preparations :00 Antihistamine Drugs :00 Anti-Infective Agents.2 12:00 Autonomic Drugs :00 Blood Formation, Coagulation and Thrombosis :00 Central Nervous System Agents... 3 The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. EFFECTIVE APRIL 1, 2012 ii

5 Table of Contents, continued 40:00 Electrolytic, Caloric, and Water Balance :00 Eye, Ear, Nose and Throat Preparations :00 Gastrointestinal Drugs :00 Skin and Mucous Membrane Agents :00 Vitamins :00 Miscellaneous Therapeutic Agents Appendices Appendix 1 Pharmaceutical Manufacturers Appendix 2 Alphabetical List of Pharmaceutical Products Appendix 3 Numerical List by Drug Identification Number The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. iii EFFECTIVE APRIL 1, 2012

6 PART 1 SECTION 1 Section 1 Policies and Guidelines Policies and Guidelines

7 ALBERTA EMPLOYMENT AND IMMIGRATION DRUG BENEFIT SUPPLEMENT INTRODUCTION Eligibility The Alberta Human Services Drug Benefit Supplement defines the drugs and drug products that are covered for Alberta Human Services, and Alberta Seniors (AISH) clients in addition to the drugs and drug products defined in the Alberta Health and Wellness Drug Benefit List (with certain exclusions). The Supplement was developed to take into consideration the essential needs of clients covered under Alberta Human Services and Alberta Seniors (AISH) programs. Additional Notes Regarding Application of the Supplement 1. The Supplement is not intended to be used as a scientific reference or prescribing guide. 2. Formularies used by hospitals and continuing care facilities are developed independently of the Supplement. 3. Drugs are classified according to the Pharmacologic Therapeutic classifications (PTC) developed by the American Society of Hospital Pharmacists for the purpose of the American Hospital Formulary Service. Permission to use this system has been granted by the American Society of Hospital Pharmacists. The Society is not responsible for the accuracy of transpositions or excerpts from the original content. Where necessary, additional PTCs may have been assigned by Alberta Blue Cross to facilitate product location in the Supplement. 4. Where appropriate, the Compendium of Pharmaceuticals and Specialties, published by the Canadian Pharmaceutical Association, was used as a reference source for the trade name, generic name, manufacturer, strength and dosage form. The Canadian Pharmacist s Association not responsible for the accuracy of transpositions or excerpts from the original content. 5. Other reference sources used for the trade name, generic name, manufacturer, strength and dosage form are: completed Drug Identification Number (DIN) notification form Notice of Compliance (NOC) Product Monograph 6. DINs listed reflect current manufacturer information available as of March 31, Interchangeable Drug Products A box containing an X to the left of the DIN or Product Identification Number (PIN) indicates that the product is not interchangeable with other products within the category. Refer to Policies and Guidelines Section 1 of the current Alberta Health and Wellness Drug Benefit List for further information regarding interchangeable drug products. The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. Section 1 1 EFFECTIVE APRIL 1, 2012

8 PRICE POLICY Price Policy The Price Policy is stated in the Alberta Health and Wellness Drug Benefit List. Additional Units of Issue for Pricing Units of issue for pricing in the Supplement are defined in the Policies and Guidelines Section 1 of the List. The following are additional units of issue that apply to the Supplement. Dosage Form Oral Pudding... Gram Rectal Pediatric Enema... Enema Rectal Pediatric Suppository... Suppository Topical Shampoo... Millilitre Oral Gum... Piece Topical Rinse... Millilitre Topical Cream/Vaginal Cream... Kit Vaginal Tablet/Topical Cream... Kit Excluded Drug Products Drugs Used in the Treatment of Infertility Unit of Issue Priced in AHSDBS All drug products used for the treatment of infertility are excluded as benefits for Alberta Human Services, Alberta Seniors (AISH) clients and are not eligible for special authorization for this indication. The following products in the current List are also excluded. Trade Name / Strength / Form Generic Name DIN Clomid 50 mg oral tablet clomiphene citrate Serophene 50 mg oral tablet clomiphene citrate Other Exclusions from the Alberta Health and Wellness Drug Benefit List The following drug products in the current Alberta Health and Wellness Drug Benefit List are excluded as benefits for Alberta Human Services, Alberta Seniors (AISH) clients unless coverage has been granted through special authorization. (Refer to Section 3 - Criteria for Special Authorization of Select Drug Products of the Supplement for more information.) Trade Name / Strength / Form Generic Name DIN Amerge 1 mg (base) oral tablet naratriptan HCl Amerge 2.5 mg (base) oral tablet naratriptan HCl Apo-Sumatriptan 50 mg tablet sumatriptan succinate Apo-Sumatriptan 100 mg tablet sumatriptan succinate The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. EFFECTIVE APRIL 1, 2012 Section 1 2

9 ALBERTA EMPLOYMENT AND IMMIGRATION DRUG BENEFIT SUPPLEMENT Trade Name / Strength / Form Generic Name DIN Co Sumatriptan 50 mg tablet sumatriptan succinate Co Sumatriptan 100 mg tablet sumatriptan succinate Imitrex DF 50 mg (base) oral tablet sumatriptan succinate Imitrex DF 100 mg (base) oral tablet sumatriptan succinate Imitrex 6 mg/syr (base) injection syringe sumatriptan succinate Imitrex 5 mg/dose (base) nasal unit dose spray sumatriptan hemisulfate Imitrex 20 mg/dose (base) nasal unit dose spray sumatriptan hemisulfate Maxalt 10 mg (base) oral tablet rizatriptan benzoate Maxalt RPD 5 mg (base) oral wafer rizatriptan benzoate Maxalt RPD 10 mg (base) oral wafer rizatriptan benzoate Mylan-Sumatriptan 50 mg tablet sumatriptan succinate Mylan-Sumatriptan 100 mg tablet sumatriptan succinate Novo-Naratriptan 1 mg tablet naratriptan HCl Novo-Naratriptan 2.5 mg tablet naratriptan HCl Novo-Sumatriptan 100 mg tablet sumatriptan succinate Novo-Sumatriptan DF 50 mg tablet sumatriptan succinate Novo-Sumatriptan DF 100 mg tablet sumatriptan succinate PMS-Sumatriptan 50 mg tablet sumatriptan succinate PMS-Sumatriptan 100 mg tablet sumatriptan succinate Sandoz Naratriptan 2.5 mg tablet naratriptan HCl Sandoz Sumatriptan 50 mg tablet sumatriptan succinate Sandoz Sumatriptan 50 mg tablet sumatriptan succinate Sumatriptan 50 mg tablet sumatriptan succinate Sumatriptan 100 mg tablet sumatriptan succinate Zomig 2.5 mg oral tablet zolmitriptan Zomig Rapimelt 2.5 mg oral dispersible tablet zolmitriptan Zomig 5 mg/dose nasal unit dose spray zolmitriptan The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. Section 1 3 EFFECTIVE APRIL 1, 2012

10 RESTRICTED BENEFITS Restricted Benefits Selected drug products in the PTCs listed below are eligible benefits with restrictions in the Supplement. For these products a comment is displayed in the Supplement after the ingredient name or specific strength for each restricted drug product. The comment initially states RESTRICTED BENEFIT and is followed by an explanation of the restriction. For eligible drug products, please refer to the applicable PTCs in the Supplement. 02:00 Pediatric Cough and Cold Preparations 04:02 Pediatric Antihistamines 12:92 Miscellaneous Autonomic Drugs 20:04.04 Antianemia Drugs (Iron Preparations) 28: Analgesics and Antipyretics Nonsteroidal Anti-Inflammatory Agents (Other Nonsteroidal Anti-Inflammatory Agents) 28: Atypical Antipsychotics 52:16 Local Anesthetics 56:12 Cathartics & Laxatives 84: Anti-Infectives Antifungals (Polyenes) 88:16 Vitamin D 88:28 Multivitamin Preparations 88:28:01 Multivitamin Preparations (Vitamins & Minerals) Example: CHLORPHENIRAMINE MALEATE/ DEXTROMETHORPHAN HBR RESTRICTED BENEFIT - This product is a benefit for patients 6 to 17 years of age inclusive MG / ML * 1 MG / ML ORAL LIQUID VICKS CHILDREN S NYQUIL COLD AND COUGH PGI The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. EFFECTIVE APRIL 1, 2012 Section 1 4

11 ALBERTA EMPLOYMENT AND IMMIGRATION DRUG BENEFIT SUPPLEMENT SPECIAL AUTHORIZATION GUIDELINES Special Authorization Policy Drug Products Eligible for Consideration by Special Authorization Drug products may be considered for coverage by special authorization under one or more of the following circumstances, unless a specific product falls under the criteria for drug products not eligible for consideration by special authorization. Please see the end of this section for information regarding drug products not eligible for consideration by special authorization. 1. The drug is covered by Alberta Health and Wellness, Alberta Human Services and/or Alberta Seniors (AISH) under specified criteria (listed in the following sections). Drug Products and indications other than those specified are not eligible for consideration by special authorization. 2. The drug is normally covered by another government program or agency for a specific approved clinical condition, but is needed for the treatment of a clinical condition that is not covered by that government program or agency. 3. The drug is required because other drug products listed in the Alberta Health and Wellness Drug Benefit List or the Alberta Human Services Drug Benefit Supplement are contraindicated or inappropriate because of the clinical condition of the patient. 4. The particular brand of drug is considered essential in the care of a patient, where the LCA price policy would otherwise apply. Coverage of a specific brand may be considered where a patient has experienced significant allergic reactions or documented untoward therapeutic effects with alternate brands in an interchangeable grouping. Coverage of a brand name product will not be considered in situations where the interchangeable grouping includes a pseudo-generic to the brand name drug. 5. A particular drug product or dosage form of a drug is essential in the care of a patient where the MAC price policy would otherwise apply. Exceptions may occur at the product level. Coverage may be considered only where a patient has experienced significant allergic reactions or documented untoward therapeutic effects with the drug product which establishes the MAC pricing. Prior approval must be granted by Alberta Blue Cross to ensure coverage by special authorization. For those special authorization requests that are approved, the effective date for authorization is the beginning of the month in which the physician s request is received by Alberta Blue Cross. Special authorization is granted for a defined period as indicated in each applicable special authorization drug product criteria (the Approval Period ). If continued treatment is necessary beyond the Approval Period, it is the responsibility of the patient and physician to re-apply for coverage prior to the expiration date of the Approved Period, unless the Auto-Renewal Process or Step Therapy Approval Process apply (see below). Auto-Renewal Process Selected drug products are eligible for the following auto-renewal process (for eligibility, see the Special Authorization criteria for each drug product). 1. For initial approval, a special authorization request must be submitted. If approval is granted, it will be effective for the Approval Period outlined in the drug product s Special Authorization criteria. 2. As long as the patient has submitted a claim for the drug product within the preceding Approval Period (example: within the preceding 6 months), approval will be automatically renewed for a further Approval Period (example: a further 6 months). There is no need for the prescriber to submit a new request as the automated real-time claims adjudication system will read the The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. Section 1 5 EFFECTIVE APRIL 1, 2012

12 patient s claims history to determine if a claim has been made within the preceding Approval Period. 3. If the patient does not make a claim for the drug product during the Approval Period, the approval will lapse and a new special authorization request must be submitted. Step Therapy Approval Process Select drug products are eligible for coverage via the step therapy process, outlined below. 1. If the patient has made a claim for the First-Line* drug product(s) within the preceding 12 months, the claim for the step therapy drug will be approved. 2. The automated real-time claims adjudication system will read the patient s claims history to determine if the required First-Line* drug product(s) have been claimed within the preceding 12 months. 3. Subsequent claims for drug product(s) permitted by step therapy will continue to be approved as long as the drug product has been claimed within the preceding 12 months. 4. The regular special authorization approval process will continue to be available for step therapy approvals for those patients whose First-Line* drug claims cannot be adjudicated through the automated real-time claims adjudication system. * A First-Line drug product includes any drug(s) or drug product(s) that, under the drug product s Special Authorization criteria, are required to be utilized before reimbursement for the drug product is permitted. Drug Products Not Eligible for Consideration by Special Authorization The following categories of drug products are not eligible for special authorization: 1. Drug products deleted from the List or the Supplement. 2. Drug products not yet reviewed by Alberta Health and Wellness and/or Alberta Human Services. This applies to: products where a complete submission has been received from the manufacturer and the product is under review, products where an incomplete submission has been received from the manufacturer, and products where the manufacturer has not made a submission for review. Drug products not yet reviewed may encompass new pharmaceutical products, new strengths of products already listed, reformulated products and new interchangeable (generic) products. 3. Drug products that have completed the review process and are not included on the List or the Supplement. 4. Most drugs available through Health Canada s Special Access Program. 5. Drug products when prescribed for cosmetic indications. 6. Nonprescription or over-the-counter drug products are generally not eligible. The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. EFFECTIVE APRIL 1, 2012 Section 1 6

13 Special Authorization Procedures A prescriber s request for special authorization should be directed to: Clinical Drug Services Alberta Blue Cross Street NW Edmonton, Alberta T5J 3C5 FAX: (780) in Edmonton and area toll-free fax for all other areas 1. For most drug products, written requests from a prescriber may be submitted on the general Drug Special Authorization Request (form number ABC 20061). Select drug products such as Donepezil/Galantamine/Rivastigmine (form number ABC 30776), Clopidogrel (form number ABC 30786), Darbepoetin/Epoetin (form number ABC 30888), Abatacept/Adalimumab/Anakinra/Etanercept/Golimumab/Infliximab/Tocilizumab for Rheumatoid Arthritis (form number ABC 30902), Ezetimibe (form number ABC 30925), Peginterferon Alfa- 2a+Ribavirin/Peginterferon Alfa-2b+Ribavirin (form number ABC 30932), Peginterferon Alfa-2a for Chronic Hepatitis C (form number ABC 30944), Etanercept for Juvenile Rheumatoid Arthritis (form number ABC 30948), Adalimumab/Etanercept/Golimumab/Infliximab for Psoriatic Arthritis (form number ABC 30964), Select Quinolones (form number 30966), Alendronate/Raloxifene/ Risedronate/Synthetic Calcitonin Salmon Nasal Spray for Osteoporosis (form number ABC 31086), Celecoxib (form number ABC 31140), Filgrastim/Pegfilgrastim (form number ABC 31150) Fentanyl (form number ABC 31169), Adalimumab/Etanercept/Infliximab/Ustekinumab for Plaque Psoriasis (Form number ABC 31192), Adalimumab/Etanercept/Golimumab/Infliximab for Ankylosing Spondylitis (form number ABC 31195), Adalimumab for Crohn s/ Infliximab for Crohn s/fistulizing Crohn s Disease (form number ABC 31200), Rituximab for Rheumatoid Arthritis (form number ABC 31205), Imiquimod (form number ABC 31222), Dutasteride/Finasteride (form number ABC 31257), Paliperidone/Risperidone Prolonged Release Injection (form number ABC 31258), Abatacept for Juvenile Idiopathic Arthritis (form number ABC 31291), Montelukast/Zafirlukast (form number ABC 31313), Febuxostat (form number 31376), Denosumab (form number 31377), Omalizumab (form number 31406) and Eculizumab (form number ABC and ABC 31408) have a unique special authorization request form. All requests for these drug products must be submitted using the applicable form. Special authorization request forms can be found on the following pages. 2. A separate request is required for each patient. 3. For a request for special authorization to be considered, the prescriber (an individual authorized by law to prescribe) must contact Alberta Blue Cross and provide the following information: Patient Identification patient s name, address and card holder s name (if different than the patient s), Alberta Human Services or Alberta Seniors client file number client file number or identification number or any other applicable coverage (e.g. Alberta Blue Cross) or Alberta Personal Health number, and date of birth. Prescriber Identification name of prescriber (e.g. physician, dentist, or optometrist), address telephone number and FAX number (if applicable), and professional association registration number (e.g. College of Physicians and Surgeons, Alberta Dental Association, or Alberta College of Optometrists registration number). The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. Section 1A 1 UPDATED APRIL 1, 2012

14 Drug Requested name, strength and dosage form, dosage schedule, and proposed duration of therapy. Reason for the Request diagnosis and/or indication for which the drug is being used, information regarding previous medications which have been used and the patient s response to therapy where appropriate, proposed results of therapy, and any additional information that may assist in making a decision on the request for special authorization. Special Authorization Forms Special Authorization forms can be found on the following pages: Drug Special Authorization Request form (ABC 20061) Donepezil/Galantamine/Rivastigmine Special Authorization Request Form (ABC 30776) - All requests for donepezil HCl, galantamine hydrobromide or rivastigmine hydrogen tartrate and must be submitted using this form only. Clopidogrel Special Authorization Request Form (ABC 30786) - All requests for clopidogrel bisulfate must be submitted using this form only. Darbepoetin/Epoetin Special Authorization Request Form (ABC 30888) - All requests for darbepoetin or epoetin alfa must be submitted using this form only. Abatacept/Adalimumab/Anakinra/Etanercept/Golimumab/Infliximab/Tocilizumab for Rheumatoid Arthritis Special Authorization Request Form (ABC 30902) - All requests for abatacept, adalimumab, anakinra, etanercept, golimumab, infliximab or tocilizumab for Rheumatoid Arthritis must be submitted using this form only. Ezetimibe Special Authorization Request Form (ABC 30925) - All requests for ezetimibe must be submitted using this form only. Peginterferon Alfa-2a+Ribavirin/Peginterferon Alfa-2b+Ribavirin Special Authorization Request Form (ABC 30932) - All requests for peginterferon alfa-2a/ribavirin or peginterferon alfa- 2b/ribavirin must be submitted using this form only. Peginterferon Alfa-2a for Chronic Hepatitis C Special Authorization Request Form (ABC 30944) - All requests for peginterferon alfa-2a for Chronic Hepatitis C must be submitted using this form only. Etanercept for Juvenile Arthritis Special Authorization Request Form (ABC 30948) - All requests for etanercept for Juvenile Idiopathic Arthritis must be submitted using this form only. Adalimumab/Etanercept/Golimumab/Infliximab for Psoriatic Arthritis Special Authorization Request Form (ABC 30964) - All requests for adalimumab, etanercept, golimumab or infliximab for Psoriatic Arthritis must be submitted using this form only. Select Quinolones Special Authorization Request Form (ABC 30966) - All requests for ciprofloxacin, levofloxacin, moxifloxacin or ofloxacin must be submitted using this form only. Alendronate/Raloxifene/Risedronate/Synthetic Calcitonin Salmon Nasal Spray for Osteoporosis Special Authorization Request Form (ABC 31086) - All requests for alendronate, raloxifene, risedronate or synthetic calcitonin salmon for Osteoporosis must be submitted using this form only. Celecoxib Special Authorization Request Form (ABC 31140) All requests for celecoxib must be submitted using this form only. The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. UPDATED APRIL 1, 2012 Section 1A 2

15 Filgrastim/Pegfilgrastim Special Authorization Request Form (form number ABC 31150) All request for filgrastim or pegfilgrastim must be submitted using this form only. Fentanyl Special Authorization Request Form (form number ABC 31169) - All requests for fentanyl or fentanyl citrate must be submitted using this form only. Adalimumab/Etanercept/Infliximab/Ustekinumab for Plaque Psoriasis Special Authorization Request Form (ABC 31192) - All requests for adalimumab, etanercept, infliximab or ustekinumab for Plaque Psoriasis must be submitted using this form only. Adalimumab/Etanercept/Golimumab/Infliximab for Ankylosing Spondylitis Special Authorization Request Form (ABC 31195) - All requests for adalimumab, etanercept, golimumab or infliximab for Ankylosing Spondylitis must be submitted using this form only. Adalimumab for Crohn s/infliximab for Crohn s/fistulizing Crohn s Disease Special Authorization Request Form (ABC 31200) - All requests for adalimumab for Moderately to Severely Active Crohn's Disease or infliximab for Moderately to Severely Active Crohn s/fistulizing Crohn s Disease must be submitted using this form only. Rituximab for Rheumatoid Arthritis Special Authorization Request Form (ABC 31205) - All requests for abatacept or rituximab for Rheumatoid Arthritis must be submitted using this form only. Imiquimod Special Authorization Request Form (ABC 31222) All requests for imiquimod must be submitted using this form only. Dutasteride/Finasteride Special Authorization Request Form (ABC 31257) All requests for dutasteride or finasteride must be submitted using this form only. Paliperidone/Risperidone Prolonged Release Injection Special Authorization Request Form (ABC 31258) All requests for paliperidone/risperidone prolonged release injection must be submitted using this form only. Abatacept for Juvenile Idiopathic Arthritis Special Authorization Request Form (ABC 31291) - All requests for abatacept for Juvenile Idiopathic Arthritis must be submitted using this form only. Montelukast/Zafirlukast Special Authorization Request Form (ABC 31313) All requests for montelukast or zafirlukast must be submitted using this form only. Febuxostat Special Authorization Request Form (ABC 31376) All requests for febuxostat must be submitted using this form only. Denosumab Special Authorization Request Form (ABC 31377) All requests for denosumab must be submitted using this form only. Omalizumab Special Authorization Request Form (ABC 31406)- All requests for omalizumab must be submitted using this form only Eculizumab Special Authorization Request Form (ABC 31386) All requests for eculizumab must be submitted using this form only. Eculizumab Consent Form (ABC 31408) All requests for eculizumab must be accompanied by this form The following official forms are provided for your convenience to photocopy and use as required. Submit completed forms by FAX to Alberta Blue Cross: (780) in Edmonton and area toll-free for all other areas Once your request has successfully transmitted, please DO NOT mail or re-fax your request The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. Section 1A 3 UPDATED APRIL 1, 2012

16 Drug Special Authorization Request Form On the reverse is the official Drug Special Authorization Request Form (ABC 20061). Photocopy this form and use as required. Submit completed forms by FAX to Alberta Blue Cross: (780) in Edmonton and area toll-free for all other areas Once your request has successfully transmitted, please do not mail or re-fax your request. The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. UPDATED APRIL 1, 2012 Section 1A 4

17 DRUG SPECIAL AUTHORIZATION REQUEST Please complete all required sections to allow your request to be processed. PATIENT INFORMATION PATIENT SURNAME FIRST NAME INITIAL DATE OF BIRTH: Year / Month / Day ALBERTA PERSONAL HEALTH NUMBER COVERAGE TYPE: Alberta Blue Cross Alberta Human Services Alberta Seniors Other STREET ADDRESS CITY PROV POSTAL CODE IDENTIFICATION/CLIENT/COVERAGE No: PRESCRIBER INFORMATION PRESCRIBER SURNAME FIRST NAME INITIAL PRESCRIBER PROFESSIONAL ASSOCIATION REGISTRATION STREET ADDRESS CITY, PROVINCE CPSA CARNA ACP PHONE: ACO ADA+C Other REGISTRATION NO. FAX: POSTAL CODE FAX NUMBER MUST BE PROVIDED WITH EACH REQUEST SUBMITTED NEW RENEWAL DRUG REQUEST Note: Request may or may not be approved by Alberta Blue Cross Drug(s), Dosage(s) and Duration Requested: Diagnosis and / or Indication which drug is being used to treat: (Include applicable information regarding previous medications, patient response to therapy and proposed results of therapy.) Additional information relating to request: PRESCRIBER S SIGNATURE DATE Please forward this request to: Alberta Blue Cross, Clinical Drug Services Street NW, Edmonton, Alberta T5J 3C5 FAX: in Edmonton toll-free all other areas ONCE YOUR REQUEST HAS SUCCESSFULLY TRANSMITTED, PLEASE DO NOT MAIL OR RE-FAX YOUR REQUEST. The information on this form is being collected and pursuant to sections 20, 21 and 22 of the Health Information Act, and sections 33 and 34 of the Freedom of Information and Protection of Privacy Act, for the purposes of determining or verifying eligibility to participate in a program or receive a benefit, product or health service. If you have any questions regarding the collection or use of this information, please contact an Alberta Blue Cross privacy matters representative toll-free at or write to Privacy Matters, Alberta Blue Cross, Street, Edmonton AB T5J 3C5. ABC (R11/2011) The Blue Cross symbol and name are registered marks of the Canadian Association of Blue Cross Plans, an association of independent Blue Cross plans. Licensed to ABC Benefits Corporation for use in operating the Alberta Blue Cross Plan.

18 Donepezil/Galantamine/Rivastigmine Special Authorization Request Form On the reverse is the official Donepezil/Galantamine/Rivastigmine Special Authorization Request Form (ABC 30776). All requests for donepezil HCl, galantamine hydrobromide or rivastigmine hydrogen tartrate must be submitted using the Donepezil/Galantamine/Rivastigmine Special Authorization Request Form only. Photocopy this form and use as required. Submit completed forms by FAX to Alberta Blue Cross: (780) in Edmonton and area toll-free for all other areas Once your request has successfully transmitted, please do not mail or re-fax your request. The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. UPDATED APRIL 1, 2012 Section 1A 6

19 DONEPEZIL/GALANTAMINE/RIVASTIGMINE SPECIAL AUTHORIZATION REQUEST FORM Please complete ALL sections to allow your request to be processed. PATIENT INFORMATION PATIENT SURNAME FIRST NAME INITIAL DATE OF BIRTH: Year / Month / Day ALBERTA PERSONAL HEALTH NUMBER Patients may or may not meet eligibility requirements as established by Alberta Government sponsored drug programs. COVERAGE TYPE: Alberta Blue Cross Alberta Human Services Alberta Seniors Other STREET ADDRESS CITY PROV POSTAL CODE IDENTIFICATION/CLIENT/COVERAGE No: PRESCRIBER INFORMATION PRESCRIBER SURNAME FIRST NAME INITIAL PRESCRIBER PROFESSIONAL ASSOCIATION REGISTRATION STREET ADDRESS CPSA CARNA ACP ACO ADA+C Other CITY, PROVINCE PHONE: FAX: REGISTRATION NO. POSTAL CODE Criteria for Coverage of DONEPEZIL, GALANTAMINE, RIVASTIGMINE FAX NUMBER MUST BE PROVIDED WITH EACH REQUEST SUBMITTED For the treatment of Alzheimer's disease in patients with an MMSE (Mini Mental State Exam) score between and/or an InterRAI-Cognitive Performance Scale score between 1-4. Coverage cannot be provided for two or more medications used in the treatment of Alzheimer's disease (donepezil, galantamine, rivastigmine) when these medications are intended for use in combination. Special authorization coverage may be granted for a maximum of 24 months per request. For each request, an updated MMSE score or InterRAI-Cognitive Performance Scale score and the date on which the exam was administered must be provided. Renewal requests may be considered for patients where the updated MMSE score is 10 or higher or the InterRAI-Cognitive Performance Scale is 4 or lower while on this drug. Note: an MMSE score below 10 or an InterRAI-Cognitive Performance Scale score greater than 4 at any time will result in discontinuation of coverage. PLEASE COMPLETE ALL SECTIONS TO ALLOW YOUR REQUEST TO BE PROCESSED Indicate which drug is requested: Donepezil Galantamine Rivastigmine Please confirm the diagnosis for which this drug is requested: For the treatment of: Dementia of the Alzheimer s Type other, please specify: Please provide a current MMSE or InterRAI-Cognitive Performance Scale score* and the date the exam was administered: MMSE Score: InterRAI-Cognitive Performance Scale Score: Date of exam: Date of exam: PRESCRIBER'S SIGNATURE DATE Please forward this request to: Alberta Blue Cross, Clinical Drug Services Street NW, Edmonton, Alberta T5J 3C5 FAX: in Edmonton toll-free all other areas The information on this form is being collected and pursuant to sections 20, 21 and 22 of the Health Information Act, and sections 33 and 34 of the Freedom of Information and Protection of Privacy Act, for the purposes of determining or verifying eligibility to participate in a program or receive a benefit, product or health service. If you have any questions regarding the collection or use of this information, please contact an Alberta Blue Cross privacy matters representative toll-free at or write to Privacy Matters, Alberta Blue Cross, Street, Edmonton AB T5J 3C5 ABC (R12/2011) The Blue Cross symbol and name are registered marks of the Canadian Association of Blue Cross Plans, an association of Independent Blue Cross plans. Licensed to ABC Benefits Corporation for use in operating the Alberta Blue Cross plan.

20 Clopidogrel Special Authorization Request Form On the reverse is the official Clopidogrel Special Authorization Request Form (ABC 30786). All requests for clopidogrel bisulfate must be submitted using the Clopidogrel Special Authorization Request Form only. Photocopy this form and use as required. Submit completed forms by FAX to Alberta Blue Cross: (780) in Edmonton and area toll-free for all other areas Once your request has successfully transmitted, please do not mail or re-fax your request. The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. UPDATED APRIL 1, 2012 Section 1A 8

21 Please complete all required sections to allow your request to be processed. CLOPIDOGREL SPECIAL AUTHORIZATION REQUEST FORM Patients may or may not meet eligibility requirements as established by Alberta Government sponsored drug programs. PATIENT INFORMATION PATIENT SURNAME FIRST NAME INITIAL DATE OF BIRTH: Year / Month / Day ALBERTA PERSONAL HEALTH NUMBER STREET ADDRESS CITY PROV POSTAL CODE COVERAGE TYPE: Alberta Blue Cross Alberta Human Services Alberta Seniors Other IDENTIFICATION/CLIENT/COVERAGE No: PRESCRIBER INFORMATION PRESCRIBER SURNAME FIRST NAME INITIAL PRESCRIBER PROFESSIONAL ASSOCIATION REGISTRATION CPSA CARNA ACO ADA+C REGISTRATION NO. STREET ADDRESS ACP Other PHONE: FAX: CITY, PROVINCE POSTAL CODE Criteria for Post-Stent Coverage For the prevention of thrombosis, for one month, when prescribed following intravascular bare metal stent placement. Patients who have received one month of coverage via the Limited Restricted Benefit will not be eligible for additional coverage under this criterion. * For the prevention of thrombosis, for up to 12 months, when prescribed following intravascular drug eluting stent (DES) placement. Patients who have received one month of coverage via the Limited Restricted Benefit may be eligible for an additional 11 months of coverage (i.e., up to 12 months of coverage) following the submission of a special authorization request. * * Special Authorization for post-stent coverage is required when the prescriber prescribing the medication is not a Specialist in Cardiology, Cardiac Surgery, Cardiovascular & Thoracic Surgery, or General Surgery; for treatment after repeat stents; or for continued coverage of up to 12 months following intravascular drug eluting stent (DES) placement. FAX NUMBER MUST BE PROVIDED WITH EACH REQUEST SUBMITTED Section I (Must complete for requests for poststent coverage) Please indicate the type and date of the stent: Date of stenting procedure: bare metal stent (1 month of coverage) drug eluting stent (12 months of coverage) For additional coverage, please proceed to Section II below Other Criteria for Coverage For the prevention of cerebrovascular (e.g. stroke, TIA) and non-cerebrovascular ischemic events in patients who have a contraindication to ASA. Special Authorization for this criterion may be granted for 24 months. For use in patients who have experienced a non-cerebrovascular ischemic event while on ASA. Special Authorization for this criterion may be granted for 24 months. For use in patients who have experienced a cerebrovascular ischemic event (e.g. stroke, TIA) while on dipyridamole/asa (Aggrenox) or for whom dipyridamole/asa (Aggrenox) is contraindicated. Special Authorization for this criterion may be granted for 24 months. Coverage will not be considered when clopidogrel and ASA/dipyridamole are intended for use in combination. Section II (Complete ALL that apply) Does this patient have a contraindication/intolerance to ASA? YES NO Please indicate the cerebrovascular ischemic event experienced: Please specify the non-cerebrovascular ischemic event experienced: stroke TIA Did the cerebrovascular event occur while this patient was on dipyridamole/asa (Aggrenox)? YES NO If applicable, please indicate which product this patient has a contraindication/intolerance to: dipyridamole/asa (Aggrenox) dipyridamole Please indicate which anti-platelet therapy this patient was on when the non-cerebrovascular event occurred: ASA other (specify): Patient was not on anti-platelet therapy PRESCRIBER 'S SIGNATURE DATE Please forward this request to: Alberta Blue Cross, Clinical Drug Services Street NW, Edmonton, Alberta T5J 3C5 FAX: in Edmonton toll-free all other areas ONCE YOUR REQUEST HAS SUCCESSFULLY TRANSMITTED, PLEASE DO NOT MAIL OR RE-FAX YOUR REQUEST. The information on this form is being collected and pursuant to sections 20, 21 and 22 of the Health Information Act, and sections 33 and 34 of the Freedom of Information and Protection of Privacy Act, for the purposes of determining or verifying eligibility to participate in a program or receive a benefit, product or health service. If you have any questions regarding the collection or use of this information, please contact an Alberta Blue Cross privacy matters representative toll-free at or write to Privacy Matters, Alberta Blue Cross, Street, Edmonton AB T5J 3C5. ABC (R11/2011) The Blue Cross symbol and name are registered marks of the Canadian Association of Blue Cross Plans, an association of independent Blue Cross plans. Licensed to ABC Benefits Corporation for use in operating the Alberta Blue Cross Plan

22 Darbepoetin/Epoetin Special Authorization Request Form On the reverse is the official Darbepoetin/Epoetin Special Authorization Request Form (ABC 30888). All requests for darbepoetin or epoetin alfa must be submitted using the Darbepoetin/Epoetin Special Authorization Request Form only. Photocopy this form and use as required. Submit completed forms by FAX to Alberta Blue Cross: (780) in Edmonton and area toll-free for all other areas Once your request has successfully transmitted, please do not mail or re-fax your request. The DBL is not a prescribing or a diagnostic tool. Prescribers should refer to drug monographs and utilize professional judgment. UPDATED APRIL 1, 2012 Section 1A 10

23 Please complete all required sections to allow your request to be processed. PATIENT INFORMATION PATIENT SURNAME FIRST NAME INITIAL DATE OF BIRTH: Year / Month / Day DARBEPOETIN/EPOETIN SPECIAL AUTHORIZATION REQUEST FORM Patients may or may not meet eligibility requirements as established by Alberta Government sponsored drug programs. ALBERTA PERSONAL HEALTH NUMBER COVERAGE TYPE: Alberta Blue Cross Alberta Human Services Alberta Seniors STREET ADDRESS CITY PROV POSTAL CODE IDENTIFICATION/CLIENT/COVERAGE No: Other PRESCRIBER INFORMATION PRESCRIBER SURNAME FIRST NAME INITIAL PRESCRIBER PROFESSIONAL ASSOCIATION REGISTRATION STREET ADDRESS CPSA CARNA ACP ACO ADA+C Other CITY, PROVINCE PHONE: FAX: REGISTRATION NO. POSTAL CODE FAX NUMBER MUST BE PROVIDED WITH EACH REQUEST SUBMITTED Indicate which drug is requested (check one box): Darbepoetin Epoetin PLEASE COMPLETE ALL APPLICABLE SECTIONS TO ALLOW YOUR REQUEST TO BE PROCESSED ANEMIA OF CHRONIC RENAL FAILURE (does not apply to epoetin 30,000 or 40,000 IU/mL strengths) anemia of chronic renal failure other, please specify: Hemoglobin level: For new patients: pre-treatment hemoglobin level (g/l): This section applies only to patients who received a renal transplant: Please indicate if the renal transplant is failing or has failed: Yes No For patients with prior special authorization for darbepoetin or epoetin with Alberta Blue Cross: current hemoglobin level (g/l): Please provide the current iron status: Serum ferritin is >100 mcg/l: Yes No AND Transferrin saturation is >20%: Yes No CHEMOTHERAPY-INDUCED ANEMIA (includes epoetin 30,000 and 40,000 IU/mL strengths) Please specify the type of cancer: other, please specify: Please provide the patient s hemogloblin level (g/l): For the treatment of anemia: Please indicate if the anemia is chemotherapy-induced: Yes No, please specify: Please specify the reason why blood transfusions are not an option: Transfusion reactions in the past Iron overload Difficulty cross-matching the patient Other, please specify: ANEMIA IN AZT-TREATED/HIV INFECTED PATIENTS (does not apply to darbepoetin nor the epoetin 30,000 or 40,000 IU/mL strength) anemia in AZT-treated/HIV infected patients other, please specify: Additional information relating to request: PRESCRIBER 'S SIGNATURE DATE Please forward this request to: Alberta Blue Cross, Clinical Drug Services Street NW, Edmonton, Alberta T5J 3C5 FAX: in Edmonton toll-free all other areas ONCE YOUR REQUEST HAS SUCCESSFULLY TRANSMITTED, PLEASE DO NOT MAIL OR RE-FAX YOUR REQUEST. The information on this form is being collected and pursuant to sections 20, 21 and 22 of the Health Information Act, and sections 33 and 34 of the Freedom of Information and Protection of Privacy Act, for the purposes of determining or verifying eligibility to participate in a program or receive a benefit, product or health service. If you have any questions regarding the collection or use of this information, please contact an Alberta Blue Cross privacy matters representative toll-free at or write to Privacy Matters, Alberta Blue Cross, Street, Edmonton AB T5J 3C5. ABC (R12/2011) The Blue Cross symbol and name are registered marks of the Canadian Association of Blue Cross Plans, an association of independent Blue Cross plans. Licensed to ABC Benefits Corporation for use in operating the Alberta Blue Cross Plan.

24 Criteria for Coverage: DARBEPOETIN DARBEPOETIN/EPOETIN SPECIAL AUTHORIZATION CRITERIA Patients may or may not meet eligibility requirements as established by Alberta Government sponsored drug programs. For the treatment of anemia of chronic renal failure in patients with low hemoglobin (<100 g/l). Hemoglobin levels should be maintained within g/l. According to current practice guidelines patients iron status should be monitored regularly, and wherever possible patients should be iron replete as demonstrated by serum ferritin >100 mcg/l and transferrin saturation >20%. For the treatment of chemotherapy-induced anemia in patients with non-myeloid malignancies with low hemoglobin (<100 g/l) in whom blood transfusions are not possible due to transfusion reactions, cross-matching difficulties or iron overload. If hemoglobin is rising by more than 20 g/l per month, the dose of Aranesp should be reduced by about 25%. In order to comply with the second criterion: if the patient has iron overload the prescriber must state this in the request or alternatively, information is required regarding the patient s transferrin saturation, along with results of liver function tests if applicable. For the first criterion, renewal requests may be considered if the patient s hemoglobin is < 120 g/l while on Aranesp. For the second criterion, renewal requests may be considered if the patient's hemoglobin is < 110 g/l while on Aranesp. EPOETIN (ALL strengths except 30,000 and 40,000 IU/mL) For the treatment of anemia of chronic renal failure in patients with low hemoglobin (< 100 g/l). Hemoglobin levels should be maintained within g/l. According to current practice guidelines patients iron status should be monitored regularly, and wherever possible patients should be iron replete as demonstrated by serum ferritin >100 mcg/l and transferrin saturation >20%. "For the treatment of anemia in AZT-treated/HIV infected patients." "For the treatment of chemotherapy-induced anemia in patients with non-myeloid malignancies with low hemoglobin (<100 g/l) in whom blood transfusions are not possible due to transfusion reactions, cross-matching difficulties or iron overload. If hemoglobin is rising by more than 20 g/l per month, the dose of Eprex should be reduced by about 25%. In order to comply with the third criterion: if the patient has iron overload the prescriber must state this in the request or alternatively, information is required regarding the patient's transferrin saturation, along with the results of liver function tests if applicable. For the first criterion, renewal requests may be considered if the patient s hemoglobin is < 120 g/l while on Eprex. For the third criterion, renewal requests may be considered if the patient's hemoglobin is < 110 g/l while on Eprex. EPOETIN 30,000 and 40,000 IU/mL strengths "For the treatment of chemotherapy-induced anemia in patients with non-myeloid malignancies with low hemoglobin (<100 g/l) in whom blood transfusions are not possible due to transfusion reactions, cross-matching difficulties or iron overload. If hemoglobin is rising by more than 20 g/l per month, the dose of Eprex should be reduced by about 25%. Patients may be granted a maximum allowable dose of 40,000 IU per week. In order to comply with this criterion, if the patient has iron overload the prescriber must state this in the request, or alternatively, information is required regarding the patient's transferrin saturation, along with the results of liver function tests, if applicable. Renewal requests may be considered if the patient's hemoglobin is <110 g/l while on Eprex. ABC (R12/2011)