Denver Shunts vs TIPS for Ascites
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1 Denver Shunts vs TIPS for Ascites Hooman Yarmohammadi MD Assistant Professor of Radiology Interventional Radiology & Image Guided Therapies Memorial Sloan-Kettering Cancer Center, New York, USA
2 Hooman Yarmohammadi, MD Research Grants: Carefusion
3 Etiology of Ascites Nonmalignant 90% Cirrhosis 80% Heart failure 3% TB, infections 2% Pancreatitis 1% Malignancy 10%
4 Etiology of Ascites Cirrhosis leading on to portal HTN 80% Ascites is the most common major complication of liver cirrhosis. Seen in 50% of patients with compensated cirrhosis within 10 yrs. Infection and other etiologies 10% Malignancy 10%
5 Treatment of Ascites Medical therapy Diuretics and Paracentesis Permanent catheters Tunneled and non-tunneled catheters and ports Internal devices or shunts TIPS and Denver shunt
6 History Peritoneovenous Shunt 1962 Smith 1966 Hyde hydrocephalus Surgically created a PVS Hyde shunt with a valve for 1974 LeVeen Designed a PVS with one-way pressure activated valve 1979 Lund and Newkirk > > Denver shunt with a manual compressible pump = in order to help with shunt occlusion
7 Denver Shunt LeVeen shunt was discontinued in the late 1990 In 1979, Robert H. Lund and Newkirk presented a unidirectional pump that could be manually compressed DENVER SHUNT
8 Denver Shunt Denver shunt is made of two silastic tube that are connected by a single valve or double valve pump.
9 Denver shunt Transmit ascitic fluid from the peritoneal cavity back into the central venous circulation.
10 TIPS (Transjugular Intra-hepatic Portosystemic Shunt)
11 Advantages of Denver shunt vs TIPS Denver shunt TIPS No external device No external device Not lifestyle limiting Not lifestyle limiting No loss of fluid/proteins No loss of fluid/proteins Can also treat variceal bleed Simple procedure Durable Early success rate (immediate) Easily reversible
12 Advantages of Denver shunt vs TIPS Denver shunt TIPS No external device No external device Not lifestyle limiting Not lifestyle limiting No loss of fluid/proteins No loss of fluid/proteins Can also treat variceal bleed Simple procedure Durable Early success rate (immediate) Easily reversible
13 Disadvantages of Denver shunt vs TIPS Denver shunt Not for everyone Complications Occlusion (30-33%) DIC Infection TIPS Not Always effective Delay resolution Needs Surveillance Difficult to reverse Complications 30-50% Encephalopathy Liver Failure Occlusion
14 Reimbursements Denver shunt vs TIPS CMS physician fee schedules Denver shunt TIPS ~$1200 ~$1200 Both are coded as In-patient procedures US-guided Paracentesis, ~$400
15 How to select?
16 Cirrhosis with Varices +/- bleeding Budd-Chiari with varices Cirrhosis with Hx of SBP TIPS No Contraindication for TIPS
17 Malignant Ascites Chylous ascites Denver Shunt Cirrhosis with no vacices Cirrhosis with no Hx of SBP Difficult/Challenging TIPS procedure NO CONTRAINDICATION for Denver shunt
18 Best for Denver Shunt Bridge for Transplant Improves renal function Significantly reduces ARF (17% vs 72%; p, 0.05)
19 Best for Denver Shunt Selected Cirrhotic patients Uncompensated hepatic encephalopathy not responding to medical Rx Allows spontaneous improvement of liver function
20 Best for Denver Shunt Selected Cirrhotic patients Transplant-eligible with MELD score > 25 in nonemergent setting = in patient with ascites only These pt have increased risk of worsening encephalopathy 50% mortality rate at 30 days Denver shunt: as bridge to Transplant
21 Best for Denver Shunt Selected Cirrhotic patients Non-transplant eligible with MELD > 18 in nonemergent setting High mortality and morbidity with TIPS
22 Best for Denver Shunt Selected Cirrhotic patients Uncompensated hepatic encephalopathy not responding to medical Rx Transplant-eligible with MELD score > 25 in nonemergent setting = in patient with ascites only Non-transplant eligible with MELD > 18 in nonemergent setting Difficult/Challenging TIPS procedure
23 Best for Denver Shunt Difficult/Challenging TIPS procedure Hepatocellular carcinoma in a critical location Portal vein occlusion Prior hepatic resection Complex cases of Budd-Chiari
24 Chylous Ascites is the BEST
25 Chylous Ascites is the BEST Our experience with 28 patients with Chylous Ascites treated with Denver shunt 100% Technical success 37% post procedure complications 0% DIC 0% mortality Successful treatment of Ascites and removal in 46% Yarmohammadi et al, Therapeutic application of Percutaneous Peritoneovenous (Denver) Shunt in treating Chylous Ascites in Cancer patients. JVIR: Accepted
26 Prospective, randomized 32 cirrhotic pt. Shunt patency = Similar (4.4 m vs 4.0 m) Survival: TIPS longer survival (28.7 m vs 16.1 m) Control of Ascites: Sooner with Denver shunt (73% after 1 months vs 46%) Long-term efficiency: TIPS effective longer(85% vs 40% at 3 years)
27 Conclusion Both TIPS and peritoneovenous shunts are effective treatments for intractable ascites. PV shunts control ascites sooner, although TIPS provides better long- term efficacy. After either shunt, numerous interventions are required to assist patency. Recommended PVS for patients with short-term life expectancy and TIPS for those with long-term life expectency
28 What are the contraindications?
29 Contraindications for Denver shunt Renal failure [if pt is not on dialysis] History of Varicose vein bleeding (90% re-bleed, half die) Grade 3 esophageal varices CHF Respiratory failure with pulmonary edema Liver failure (T Bili > 2.0) Bloody ascites Low plt counts < 50 x 10 9 High INR > 2.0 or subclinical DIC Peritonitis or History of SBP Poor performance status
30 Relative Contraindications for Denver shunt Renal insufficiency not related to HepatoRenal Syndrome Compensated CHF Loculated ascites or severe peritoneal adhesions Patients planned to get laparoscopic procedure Peritoneal disease Peritoneal mesothelioma
31 Contraindications for TIPS Hepatic encephalopathy Poor hepatic function Poor performance status
32 Summary & Recommendations TIPS Cirrhosis with Varices +/- bleeding Budd-Chiari with varices Cirrhosis with History of SBP
33 Summary & Recommendations Denver shunt Malignant Ascites Chylous ascites Cirrhotic pt. with no varices or history of SBP Uncompensated hepatic enc. Transplant-eligible with MELD score > 25 in nonemergent setting Non-transplant eligible with MELD > 18 in nonemergent setting Difficult/Challenging TIPS procedure
34 Thank you
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