MATERIAL SAFETY DATA SHEET Buffer solution ph 10 (borate) traceable to NIST, colored blue

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1 MATERIAL SAFETY DATA SHEET Buffer solution ph 10 (borate) traceable to NIST, colored blue MSDS Name: Text for R phrases: see Section 16 Section 1 Chemical Product and Company Identification Catalog Numbers: , Synonyms: Company Identification: Company Identification: (USA) For information in the US, call: Buffer solution ph 10 (borate) traceable to NIST, colored blue Acros Organics BVBA Janssen Pharmaceuticalaan 3a 2440 Geel, Belgium Acros Organics One Reagent Lane Fair Lawn, NJ ACROS 01 For information in Europe, call: Emergency Number, Europe: Emergency Number US: CHEMTREC Phone Number, US: CHEMTREC Phone Number, Europe: Section 2 Composition, Information on Ingredients CAS# Chemical Name: % EINECS# Hazard Symbols: Risk Phrases: Thymol blue 00003% Sodium hydroxide 0175% C Potassium chloride 0373% Water Balance Boric acid 0,309% T Hazard Symbols: None listed Risk Phrases: None listed Section 3 Hazards Identification Potential Health Effects EMERGENCY OVERVIEW Eye: Skin: Ingestion: Inhalation: Chronic: May cause eye irritation May cause skin irritation May be harmful if absorbed through the skin May cause irritation of the digestive tract May be harmful if swallowed May cause respiratory tract irritation May be harmful if inhaled Section 4 First Aid Measures

2 Eyes: Skin: Ingestion: Inhalation: Notes to Physician: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids Get medical aid Get medical aid Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes Get medical aid Wash mouth out with water Remove from exposure and move to fresh air immediately Treat symptomatically and supportively Section 5 Fire Fighting Measures General Information: Extinguishing Media: As in any fire, wear a self contained breathing apparatus in pressure demand, MSHA/NIOSH (approved or equivalent), and full protective gear Substance is noncombustible; use agent most appropriate to extinguish surrounding fire Section 6 Accidental Release Measures General Information: Spills/Leaks: Use proper personal protective equipment as indicated in Section 8 Absorb spill with inert material (eg vermiculite, sand or earth), then place in suitable container Section 7 Handling and Storage Handling: Storage: Avoid breathing dust, vapor, mist, or gas Avoid contact with skin and eyes Store in a cool, dry place Store in a tightly closed container Section 8 Exposure Controls, Personal Protection Engineering Controls: Use adequate ventilation to keep airborne concentrations low Exposure Limits CAS# : CAS# : United Kingdom, WEL STEL: 2 mg/m3 STEL United States OSHA: 2 mg/m3 TWA Belgium TWA: 2 mg/m3 VLE France VME: 2 mg/m3 VME Germany: 2 mg/m3 TWA (inhalable fraction) Japan: 2 mg/m3 Ceiling Malaysia: 2 mg/m3 Ceiling Spain: 2 mg/m3 VLA EC CAS# : CAS# : CAS# : Personal Protective Equipment Eyes: Wear chemical splash goggles

3 Skin: Clothing: Wear appropriate protective gloves to prevent skin exposure Wear appropriate protective clothing to prevent skin exposure Respirators: Follow the OSHA respirator regulations found in 29 CFR or European Standard EN 149 Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced Section 9 Physical and Chemical Properties Physical State: Clear liquid Color: blue Odor: odorless ph: 10 Vapor Pressure: Viscosity: Boiling Point: Freezing/Melting Point: Autoignition Temperature: Flash Point: Explosion Limits: Lower: Explosion Limits: Upper: Decomposition Temperature: Solubility in water: Miscible Specific Gravity/Density: 1000 Molecular Formula: Molecular Weight: Section 10 Stability and Reactivity Chemical Stability: Conditions to Avoid: Incompatibilities with Other Materials Hazardous Decomposition Products Hazardous Polymerization Stable Has not been reported Section 11 Toxicological Information RTECS#: LD50/LC50: CAS# : XP CAS# : WB CAS# : TS CAS# : ZC CAS# : ED ED CAS# : Draize test, rabbit, eye: 400 ug Mild; Draize test, rabbit, eye: 1% Severe; Draize test, rabbit, eye: 50 ug/24h Severe; Draize test, rabbit, eye: 1 mg/24h Severe; Draize test, rabbit, skin: 500 mg/24h Severe; CAS# : Draize test, rabbit, eye: 500 mg/24h Mild; Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 2600 mg/kg; CAS# : Oral, rat: LD50 = >90 ml/kg;

4 CAS# : Oral, mouse: LD50 = 3450 mg/kg; Oral, rat: LD50 = 2660 mg/kg; Oral, rat: LD50 = 2500 mg/kg; Carcinogenicity: Thymol blue Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65 Sodium hydroxide Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65 Potassium chloride Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65 Water Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65 Boric acid Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65 Other: The toxicological properties have not been fully investigated See actual entry in RTECS for complete information Section 12 Ecological Information Section 13 Disposal Considerations Dispose of in a manner consistent with federal, state, and local regulations Shipping Name: Hazard Class: UN Number: Packing Group: Section 14 Transport Information IATA IMO RID/ADR Not regulated as a Not regulated as a Not regulated as a hazardous material hazardous material hazardous material USA RQ: CAS# : 1000 lb final RQ; 454 kg final RQ European/International Regulations Section 15 Regulatory Information European Labeling in Accordance with EC Directives Hazard Symbols: Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes WGK (Water Danger/Protection) Canada US Federal TSCA CAS# : CAS# : 1 CAS# : 1 CAS# : CAS# : 1 CAS# is listed on Canada's DSL List CAS# is listed on Canada's DSL List CAS# is listed on Canada's DSL List CAS# is listed on Canada's DSL List CAS# is listed on Canada's DSL List CAS# is listed on the TSCA Inventory

5 CAS# is listed on the TSCA Inventory CAS# is listed on the TSCA Inventory CAS# is listed on the TSCA Inventory CAS# is listed on the TSCA Inventory Text for R phrases from Section 2 R 35 Causes severe burns R 60 May impair fertility R 61 May cause harm to the unborn child Section 16 Other Information MSDS Creation Date: 11/08/2004 Revision #0 Date Original The information above is believed to be accurate and represents the best information currently available to us However, we make no warranty of merchantibility or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use Users should make their own investigations to determine the suitability of the information for their particular purposes In no event shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential, or exemplary damages howsoever arising, even if the company has been advised of the possibility of such damages

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