A precision medicine approach to comprehensive NAFLD diagnosis via metabolomics-based liquid biopsy
|
|
|
- Randell Thomas
- 6 years ago
- Views:
Transcription
1 A precision medicine approach to comprehensive NAFLD diagnosis via metabolomics-based liquid biopsy International Workshop on NASH Biomarkers May , Washington D.C. Pablo Ortiz, MD, PhD (OWL CEO)
2 Sample cohort Clinical Database with histologically-verified Liver biopsy: A total of 817 subjects with NAFLD and 130 controls were included Cohort of subjects from the USA and Europe Liver histology was assessed by NASH CRN criteria Serum and EDTA-plasma (n=947) collected under fasting conditions at the time of liver biopsy: Development of the models: An initial cohort of 652 samples Validation: independent cohorts (n=295) or leave-one-out cross validation (LOOCV) In a subset of the serum cohort (n=114) concomitant hepatic fat content using MRI-fat fractions is also available Samples have been characterized through comprehensive metabolomics analysis (J Prot Res 2012, 11:2521) 2
3 Clinical Validation Patient cohort Discovery Trial 467 biopsied patients 11 participating hospitals: Hospital Clinic Barcelona Hospital Marqués de Valdecilla Hospital Virgen de Valme Hospital Universitario Reina Sofia Hospital Universitario Virgen de la Victoria Hospital Universitario 12 de Octubre Hospital Universitario Principe de Asturias Hospital Universitario del Tajo Hospital Universitario Santa Cristina Keck Hospital of USC Institute Nacionale de la Santé et dela Recherche Médicale (INSERM) HEALTHY LIVER STEATOSIS NASH Barr J, et al. J Prot Res 2012;11:
4 ROC Curves OWLiver 3.0 AUC 0.90 ± 0.02 Sensitivity: 0.98 Specificity: 0.78 Pos Pred Value: 0.89 Neg Pred Value: 0.88 AUC 0.95 ± 0.01 Sensitivity: 0.83 Specificity: 0.94 Pos Pred Value: 0.89 Neg Pred Value:
5 Clinical Blind Validation Patient cohort Validation Trial 294 additional biopsied patients (new cohort) 2 countries: Czech Republic and Spain 6 Hospitals Hospital Marques de Valdecilla Hospital Virgen de Valme Hospital Clínico Universitario Valladolid Hospital Clinic Barcelona Donostia University Hospital Faculty of Medicine, Charles Univ. of Prague Blind Validation HEALTHY LIVER STEATOSIS NASH A Non-Invasive Lipidomic Test Accurately Discriminates Non-Alcoholic Steatohepatitis from Steatosis: A Blind Validation Study J. Crespo, I. Martínez-Arranz, M. Romero-Gómez, R. Mayo, R.A. De La Fuente, J. Caballería, D.A. de Luis, C. Alonso, L. Vitek, P. Ortiz, R. Bruha Journal of Hepatology, Vol. 64, Issue 2, S478 5
6 Serum metabolic biomarkers of NAFLD Study group: 467 biopsied subjects with Normal Liver (n=90) or NAFLD (377): Steatosis (246), NASH(131) NAFLD index = (BMI, relative concentration of 11 TG) AUROC = 0.90; Sensitivity = 0.98; Specificity = 0.78; PPV = 0.89; NPV = 0.88 Validation group: 294 biopsied subjects with Normal Liver (n=39) or NAFLD (n=255): Steatosis (108), NASH (147) NAFLD index = (BMI, relative concentration of 11 TG) AUROC = 0.95; Sensitivity = 0.96; Specificity = 0.82; PPV = 0.97; NPV = 0.78 Study cohort Validation cohort Journal of Hepatology, Vol. 64, Issue 2, S478 6
7 3 NASH diagnosis: Validation Study group: 540 metabolites were profiled by LC/MS in serum samples from 377 biopsied NAFLD subjects: Steatosis (246), NASH (131) NASH index = (BMI, relative concentration of 20 TG) AUROC = 0.95; Sensitivity = 0.83; Specificity = 0.94 Validation group: 255 biopsied NAFLD subjects: Steatosis (n=108), NASH (147) NASH index = (BMI, relative concentration of 20 TG) AUROC = 0.84; Sensitivity = 0.79; Specificity = 0.92 Study cohort Validation cohort Journal of Hepatology, Vol. 64, Issue 2, S478 7
8 Noninvasive diagnosis of NAFLD and NASH based on lipidomics Discovery and validation of test based on twenty-eight serum triglycerides NAFLD vs. Normal Liver Total Control NAFLD AUC Test (N) ±0.02 Validation (N) ±0.04 NASH vs. NAFL Total NAFL NASH AUC Test (N) ±0.01 Validation (N) ±0.03 Test cohort Validation cohort Barr J, et al. J Prot Res 2010 & 2012
9 4 Fibrosis Assessment Non-invasive assay for tracking severity of the disease based on plasma metabolomics Discovery Trial Plasma samples from USA: VCU (Dr. Sanyal) Patients: 105 Central reading of all 225 patients at VCU. Final results are based in a total of 208 NAFLD patients. Validation Trial Samples from Switzerland and Spain: Inselspital - Bern University Hospital (Dr. Dufour) H. Universitario de Valme (Dr. Romero) H. Universitario Santa Cristina (Dr. García-Monzón) H. Universitario Príncipe de Asturias (Dr. Martín-Duce) Patients: 120 CONTROL NAFLD F1-F2 F3-F4 9
10 4 Fibrosis Assessment: NAFLD progression Heatmap combining discovery and validation cohorts 10
11 Noninvasive fibrosis assesment 16 metabolites were included: phospholipids, triglycerides and nonesterified fatty acids F0 vs. F1-4 Test cohort Validation cohort
12 2 Steatosis severity Correlation between Metabolic Serum Profile and MRI 114 biopsied patients Obese population Correlation between the Lipidomic Signature and MRI (r=0.81, p<0.0001) BMC medicine, 2014, 12:137 12
13 Aims: A Comprehensive NAFLD Diagnosis To develop metabolomics based models on liquid biopsy to Healthy Liver 1 Differentiate NAFLD from controls NAFLD Diagnosis (Screening) Steatosis 2 Assess severity of Steatosis NASH 3 Distinguish between NAFL and NASH NASH Diagnosis Cirrhosis 4 Identify the presence of Any Fibrosis or Advanced Fibrosis (stage 3 or 4) in NAFLD
14 Acknowledgments Arun J. Sanyal Michael O. Idowu Cristina Alonso Ibon Martínez-Arranz Rebeca Mayo Itziar Mincholé Azucena Castro Pablo Ortiz José M Mato Mazen Noureddin Jesus Bañales Raul Jiménez-Agüero Luis Bujanda And J.F. Dufour M Romero-Gómez J. Caballería R. Bruha J. Crespo R. Aller J. Muntané C. García-Monzón A. Martín-Duce B. O. Lo Iacono M. Pérez-Carreras K. Klement P. Gual Pierre Bedossa 14
Identification and Quantification of Fat in the Liver by MRI and its Correlation with Serum Metabolomics Jesús M. Banales, PhD
Identification and Quantification of Fat in the Liver by MRI and its Correlation with Serum Metabolomics Jesús M. Banales, PhD Head, Liver Diseases Group Biodonostia Institute, San Sebastian (Spain) Non
OWL will be presenting new innovations in liver disease diagnosis at the ILC2016 in Barcelona. We have an oral presentation and four posters.
OWL Abstracts at 1 OWL will be presenting new innovations in liver disease diagnosis at the ILC2016 in Barcelona. We have an oral presentation and four posters. 2 IDENTIFICATION OF LIPIDOMIC SIGNATURES
Lipid and Bile Acids as NAFLD- Related Biomarkers
Lipid and Bile Acids as NAFLD- Related Biomarkers Puneet Puri, MBBS, MD Division of Gastroenterology, Hepatology and Nutrition Virginia Commonwealth University, Richmond, VA 1st International Workshop
Liver biopsy as the gold standard for diagnosis. Pierre BEDOSSA
Liver biopsy as the gold standard for diagnosis Pierre BEDOSSA 1 PATHOLOGY OF NAFLD CONFLICTS OF INTEREST Grants and funding from Genfit, Intercept, Allergan, Inventiva, OWL, Echosens CEO and funding of
Novel multiparametric magnetic resonance elastography (MRE) protocol accurately predicts NAS score for NASH diagnosis
Novel multiparametric magnetic resonance elastography (MRE) protocol accurately predicts NAS score for NASH diagnosis Alina M. Allen, Meng Yin, Sudhakar K. Venkatesh, Taofic Mounajjed, Todd A. Kellogg,
NAFLD: evidence-based management. Curso de residentes AEEH Salvador Augustin, MD Liver Unit Vall d Hebron Hospital Barcelona, Spain
NAFLD: evidence-based management Curso de residentes AEEH 2017 Salvador Augustin, MD Liver Unit Vall d Hebron Hospital Barcelona, Spain Clinical case - 55 yo female - Sent for incidental steatosis at abdominal
DIAGNOSIS OF NASH LIVER BIOPSY. PHC
DIAGNOSIS OF NASH LIVER BIOPSY PHC 2018 - www.aphc.info 1 THE NATURAL HISTORY OF NAFLD STEATOSIS (NAFL) STEATOHEPATITIS (NASH) FIBROSIS CIRRHOSIS HCC UNDER THE LENS : THE 3 HISTOLOGICAL COMPONENTS OF NAFLD
Non-Alcoholic Fatty Liver Diseasean underestimated epidemic
Non-Alcoholic Fatty Liver Diseasean underestimated epidemic Amir Shlomai MD,PhD Head, Department of Medicine D The Liver Institute Rabin Medical Center, Beilinson Hospital The IASLD semi-annual meeting-
Prognosis of NASH VII Workshop Intenracional de Actualizaçao em Hepatologia, Aug 29th 2014
Prognosis of NASH VII Workshop Intenracional de Actualizaçao em Hepatologia, Aug 29th 2014 Vlad Ratziu, Université Pierre et Marie Curie, Hôpital Pitié Salpêtrière, Paris, France NASH : a severe hepatic
M30 Apoptosense ELISA. A biomarker assay for detection and screening of NASH
M30 Apoptosense ELISA A biomarker assay for detection and screening of NASH NASH A Global Disease In the Western countries, Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common liver disease, strongly
PHC, Paris, 30th Jan 2017 PATHOLOGY OF NAFLD. Pierre Bedossa. Departement of Pathology Hôpital Beaujon University Paris-Diderot Paris - FRANCE
PHC, Paris, 30th Jan 2017 PATHOLOGY OF NAFLD Pierre Bedossa Departement of Pathology Hôpital Beaujon University Paris-Diderot Paris - FRANCE 1 PATHOLOGY OF NAFLD NAFLD: a chronic liver disease with a wide
Disease Burden of Non Alcoholic Fatty Liver Disease (NAFLD)
Disease Burden of Non Alcoholic Fatty Liver Disease (NAFLD) Dr. H. Razavi May 31, 2017 First European NASH NAFLD Summit Disclosure: This work with funded by a multi-sponsored research grant from Intercept,
Normal ALT for men 30 IU/L 36% US males abnormal. Abnl ALT. Assess alcohol use/meds. Recheck in 6-8 weeks. still pos
Fatty liver disease Its not just for big boys anymore Ken Flora, MD, FAASLD, FACG, AGAF No disclosures Common situation Normal ALT for men 30 IU/L 36% US males abnormal Normal ALT for women 20 IU/L 28%
Non-invasive diagnostic biomarkers
Non-invasive diagnostic biomarkers Liver Forum, November 12 th, 2015 Rohit Loomba, MD, MHSc Professor of Medicine (with tenure) Director, NAFLD Research Center, Division of Gastroenterology, Department
Evercore ISI Presentation- Madrigal
Evercore ISI Presentation- Madrigal Forward-Looking Statements Any statements, other than statements of historical facts, made in this presentation regarding our clinical studies and our research and development
EVALUATION REPORT
International Workshop on NASH Biomarkers 2017 5-6 May 2017 Washington, D.C., EVALUATION REPORT www.expertmedicalevents.com/nashbiomarkers EXECUTIVE SUMMARY INTRODUCTION The 2 nd International Workshop
Understanding your FibroScan Results
PATIENT & CAREGIVER EDUCATION Understanding your FibroScan Results This information will help you understand your FibroScan results. About FibroScan FibroScan is a specialized ultrasound machine for your
Big Data Training for Translational Omics Research. Session 1, Day 3, Liu. Case Study #2. PLOS Genetics DOI: /journal.pgen.
Session 1, Day 3, Liu Case Study #2 PLOS Genetics DOI:10.1371/journal.pgen.1005910 Enantiomer Mirror image Methadone Methadone Kreek, 1973, 1976 Methadone Maintenance Therapy Long-term use of Methadone
NASH : Diagnosis and investigation. VII Workshop international, Curitiba, Brazil 29/08/2014
NASH : Diagnosis and investigation VII Workshop international, Curitiba, Brazil 29/08/2014 Vlad Ratziu, Université Pierre et Marie Curie, Hôpital Pitié Salpêtrière, Paris, France Usual diagnostic circumstances
Steatotic liver disease
Steatotic liver disease Fatty liver disease Prof. Dr. ANNE HOORENS Non-Neoplastic Liver Pathology December 8th 2018 Working Group of Digestive Pathology Belgian Society of Pathology OUTLINE NAFLD = Non-Alcoholic
LION-HEART. Levosimendan Intermittent administration in Outpatients: effects on Natriuretic peptides in advanced chronic HEART failure
LION-HEART Levosimendan Intermittent administration in Outpatients: effects on Natriuretic peptides in advanced chronic HEART failure Multicentre, randomized, double-blind, parallel group, placebo-controlled
NONINVASIVE IMAGING METHODS FOR ASSESSMENT OF LIVER DAMAGE IN NASH
NONINVASIVE IMAGING METHODS FOR ASSESSMENT OF LIVER DAMAGE IN NASH Bachir Taouli, MD Director of Body MRI and Cancer Imaging Program Department of Radiology / Translational and Molecular Imaging Institute
The role of non-invasivemethods in evaluating liver fibrosis of patients with non-alcoholic steatohepatitis
The role of non-invasivemethods in evaluating liver fibrosis of patients with non-alcoholic steatohepatitis Objectives: Liver biopsy is the gold standard for diagnosing the extent of fibrosis in NAFLD/NASH;
Liver Pathology in the 0bese
Liver Pathology in the 0bese Rob Goldin Centre for Pathology, Imperial College r.goldin@imperial.ac.uk Ludwig et al. Non-alcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease.
Nonalcoholic Fatty Liver Disease: Definitions, Risk Factors, and Workup
REVIEW REVIEW Nonalcoholic Fatty Liver Disease: Definitions, Risk Factors, and Workup Puneet Puri, M.B.B.S., M.D. and Arun J. Sanyal, M.B.B.S., M.D. Nonalcoholic fatty liver disease (NAFLD) is defined
C-reactive protein levels in relation to various features of non-alcoholic fatty liver
C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients Esther Zimmermann 1,2, Rodolphe Anty 3,4,5, Joan Tordjman 6,7,8, An Verrijken 9, Philippe
Update on Non-Alcoholic Fatty Liver Disease. Timothy R. Morgan, MD Chief, Hepatology, VA Long Beach Professor of Medicine, UCI
Update on Non-Alcoholic Fatty Liver Disease Timothy R. Morgan, MD Chief, Hepatology, VA Long Beach Professor of Medicine, UCI February 3, 2018 Disclosure Clinical trials: Genfit Speaker s Bureau: none
The role of ARFI and APRI in diagnosis of liver fibrosis on patients with common chronic liver diseases
RESEARCH ARTICLE The role of ARFI and APRI in diagnosis of liver fibrosis on patients with common chronic liver diseases Objective: This study aimed to investigate the value of liver fibrosis assessment
NONALCOHOLIC FATTY LIVER DISEASE. Non-Alcoholic Fatty Liver Disease (NAFLD) Primary NAFLD. April 13, 2012
NONALCOHOLIC FATTY LIVER DISEASE Kiran Bambha, MD University of Colorado Denver April 13, 2012 Non-Alcoholic Fatty Liver Disease (NAFLD) Primary NAFLD Simple Steatosis Fatty hepatocytes Intracellular fat
Fatty liver disease: What do we know?
Fatty liver disease: What do we know? Prof. Dr. Claus Niederau Katholische Kliniken Oberhausen ggmbh St. Josef-Hospital Academic Teaching Hospital University of Duisburg-Essen NAFLD Non-Alcoholic Fatty
Preface: Nonalcoholic Fatty Liver Disease: An Expanding Health Care Epidemic
NASH and NAFLD Preface: Nonalcoholic Fatty Liver Disease: An Expanding Health Care Epidemic David E. Bernstein xiii Clinical and Economic Burden of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
The place of bariatric surgery in NASH: can we extend the indications? - No
The place of bariatric surgery in NASH: can we extend the indications? - No Nicolas Goossens Service de Gastroentérologie & Hépatologie Hôpitaux Universitaires de Genève Genève, Suisse How to extend the
Yun-Jung Choi, Jiangao Song, Jeff D. Johnson, Charles McWherter. NASH-TAG Conference Park City, Utah January 4, 2019
Combination Therapy of Seladelpar and Liraglutide Attenuates Obesity, Hepatic Steatosis and Fibrosis in a Diet-induced and Biopsy-confirmed Mouse Model of NASH Yun-Jung Choi, Jiangao Song, Jeff D. Johnson,
ABSTRACTS
International Workshop on NASH Biomarkers 207 5-6 May 207 Washington, D.C., USA ABSTRACTS www.expertmedicalevents.com/nashbiomarkers ABSTRACTS 0 Hepatic proton density fat fraction correlates with histologic
Quantitative Assessment of the Liver: Breath Tests. M. Shadab Siddiqui, M.D. Virginia Commonwealth University
Quantitative Assessment of the Liver: Breath Tests M. Shadab Siddiqui, M.D. Virginia Commonwealth University Objectives Principles of breath tests Breath tests in NAFLD Potential applications of breath
NAFLD AND TYPE 2 DIABETES
NAFLD AND TYPE 2 DIABETES Sonia Caprio, MD STOPNASH Symposium on the Origin and Pathways of Nonalcoholic Steatohepatitis Washington 7, 215 Global Projection of Diabetes Hossain P et al. N Engl J Med 27;356:213
MEETING PROSPECTUS. International Workshop on NASH Biomarkers
International Workshop on NASH Biomarkers 2018 18-19 May 2018 Washington, D.C., USA MEETING PROSPECTUS www.expertmedicaleducation.com www.expertmedicalevents.com ADVANCING HEALTH GLOBALLY THROUGH INNOVATIVE
Diabetes Liver Screen
YOUR LIVER AND YOUR HEALTH Diabetes Liver Screen Non-Alcoholic Fatty Liver Disease (NAFLD) PROF. SUZANNE NORRIS www.liverwellness.ie The spectrum of non-alcoholic fatty liver disease Diabetes Liver Screen
NAFLD and NASH: The Not-So-New Kids on the Block
NAFLD and NASH: The Not-So-New Kids on the Block Mary E. Rinella, MD Associate Professor of Medicine Feinberg School of Medicine Northwestern University Chicago, Illinois This program is supported by an
INTERNATIONAL WORKSHOP ON MANAGEMENT OF END STAGE LIVER DISEASE DUE TO NASH WASHINGTON DC, USA 6-7 OCTOBER 2016 MEETING PROSPECTUS www.expertmedicalevents.com www.expertmedicalevents.com INTRODUCTION NAFLD
National Horizon Scanning Centre. Enhanced Liver Fibrosis Test (ELF) for evaluating liver fibrosis. June 2008
Enhanced Liver Fibrosis Test (ELF) for evaluating liver fibrosis June 2008 This technology summary is based on information available at the time of research and a limited literature search. It is not intended
Transient elastography in chronic liver diseases of other etiologies
4 Post Meeting A.I.S.F. Unmet Clinical Needs in Hepatology: New and upcoming diagnostic tools" Transient elastography in chronic liver diseases of other etiologies Dr. Vincenza Calvaruso Gastroenterologia
Non-Alcoholic Steatohepatitis (NASH): What the Gastroenterologist Should Know
Non-Alcoholic Steatohepatitis (NASH): What the Gastroenterologist Should Know Naga P. Chalasani, MD, FACG Professor of Medicine and Cellular & Integrative Physiology Director, Division of GI and Hepatology
METABOLIC SYNDROME AND HCV: FROM HCV
METABOLIC SYNDROME AND HCV: FROM THEORY TO PRACTICE HCV Steatosis Insulin resistance Arun J Sanyal M.D. Chairman, Div. of Gastroenterology, Hepatology and Nutrition Virginia Commonwealth University Richmond,
Diseases to Watch. Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic
Diseases to Watch Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic steatohepatitis (NASH) - Prevalence and Symptoms - Risk Factors and Potential treatments - Target identification for NASH Robert
HEP DART 2017, Kona, Hawaii
HEP DART 2017, Kona, Hawaii Rong Yu 1, Ke Xu 1, Jing Li 1, Tong Sun 1, Shengjiang Zhang 2, Jinhua Shao 2, Jin Sun 2, Qiong He 3, Jianwen Luo 3, Cheng Wang 4, Yudong Wang 4, Jing Chen 4, Vanessa Wu 4, George
Paris Hepatology Conference PROGNOSIS OF NASH
Paris Hepatology Conference PROGNOSIS OF NASH Palais des Congrès Monday 15th January 2018 14:45-15:00 PHC 2018 - www.aphc.info Driven to care Disclosures Advisory committees Speaking and teaching Research
A pathologist, a radiologist and a hepatologist walked into a bar
A pathologist, a radiologist and a hepatologist walked into a bar Brent A. Neuschwander-Tetri, MD, FAASLD Professor of Internal Medicine Director, Division of Gastroenterology and Hepatology Saint Louis
Methods of MR Fat Quantification and their Pros and Cons
Methods of MR Fat Quantification and their Pros and Cons Michael Middleton, MD PhD UCSD Department of Radiology International Workshop on NASH Biomarkers Washington, DC April 29-30, 2016 1 Disclosures
At Least 1 in 5 Patients in Your Practice Have Fatty Liver
At Least 1 in 5 Patients in Your Practice Have Fatty Liver What Can You Tell Your Patients Magnus McLeod MD FRCPC Assistant Professor Dalhousie University 30-NOV-2017 NAFLD Non-Alcoholic Fatty Liver Disease
FDA Introductory Remarks Stephanie O. Omokaro, MD
FDA Introductory Remarks Stephanie O. Omokaro, MD Division of Gastroenterology & Inborn Errors Products (DGIEP) Center for Drug Evaluation and Research Office of New Drugs Office of Drug Evaluation III
UMHS-PUHSC JOINT INSTITUTE
Role of Visceral Adiposity in the Pathogenesis of Non-Alcoholic Fatty Liver Disease in Lean versus Obese Patients: A Comparative Study between Patients at UMHS versus PUHSC Lai WEI and Anna LOK W Zhang,
/ FIB4 Index , simple steatosis. FIB4 Index. FIB4 Index. FIB4 Index FIB4 Index. Sterling FIB4 Index. FIB4 Index AST AST ALT
原 著 29 34-41, 2014 FIB4 Index 1 1 1 1 2 1 1 FIB4 Index FIB4 Index cut off 2.67 2.67 12,059 FIB4 IndexFIB4 Index 2.67 / FIB4 Index AST ALT FIB4 Index 2.67 161 1.3% FIB4 Index 5 FIB4 Index 1.1 5 1.6 FIB4
AAIM: GI Workshop Follow Up to Case Studies. Non-alcoholic Fatty Liver Disease Ulcerative Colitis Crohn s Disease
AAIM: GI Workshop Follow Up to Case Studies Non-alcoholic Fatty Liver Disease Ulcerative Colitis Crohn s Disease Daniel Zimmerman, MD VP and Medical Director, RGA Global October 2015 Non-alcoholic Fatty
2 nd International Workshop on NASH Biomarkers, Washington DC, May 5-6, 2017
Hepatic Proton Density Fat Fraction Correlates With Histologic Measures of Steatosis and Is Responsive to Changes in Those Measures in a Multi-center Nonalcoholic Steatohepatitis Clinical Trial Michael
Case #1. Digital Slides 11/6/ year old woman presented with abnormal liver function tests. Liver Biopsy to r/o autoimmune hepatitis
45 year old woman presented with abnormal liver function tests Liver Biopsy to r/o autoimmune hepatitis Further down. ANA 1: 160; ASMA 1:80 ANA 1: 160; ASMA 1:80 IgG = 14.5 g/l (upper normal range: 16)
OBESITY HYPOVENTILATION SYNDROME: CPAP vs NIV. J. F. Masa San Pedro de Alcántara Hospital Cáceres. Spain
OBESITY HYPOVENTILATION SYNDROME: CPAP vs NIV J. F. Masa San Pedro de Alcántara Hospital Cáceres. Spain Hypoventilation mechanisms OHS NIV action CPAP action Mechanical load Leptin resistance Breathing
NASH UPDATE ON DIAGNOSTICS AND THERAPY. Arun J Sanyal MBBS, MD Virginia Commonwealth University School of Medicine
NASH UPDATE ON DIAGNOSTICS AND THERAPY Arun J Sanyal MBBS, MD Virginia Commonwealth University School of Medicine Conflicts of interest Salaried employee: of VCU Member of Board: McGuire VA Research Institute,
Improving Access to Quality Medical Care Webinar Series
Improving Access to Quality Medical Care Webinar Series Presented by The Arizona Telemedicine Program and the Southwest Telehealth Resource Center 2015 UA Board of Regents Welcome AZ, UT, CO, NM & NV FLEX
Assessment of Liver Stiffness by Transient Elastography in Diabetics with Fatty Liver A Single Center Cross Sectional observational Study
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 16, Issue 6 Ver. IV (June. 2017), PP 49-53 www.iosrjournals.org Assessment of Liver Stiffness by Transient
CLINICAL CHARACTERISTICS AND OUTCOME OF HEART TRANSPLANT IN ADULTS WITH CONGENITAL HEART DISEASES
CLINICAL CHARACTERISTICS AND OUTCOME OF HEART TRANSPLANT IN ADULTS WITH CONGENITAL HEART DISEASES Subanalysis Spanish Registry on Heart TransplantaCon (1984 2010) Authors: Dimpna C. Albert 1 María J. Paniagua
July 5 & 6, 2018, Paris SCIENTIFIC PROGRAM
www.paris-nash.org Dear Colleagues, We are delighted to announce the 4th Paris NASH Meeting to be held on July 5-6 th 2018. This international academic meeting is aimed to do a deep-dive into many aspects
PARQUE DE LAS CIENCIAS PROGRAM
15 & 16 September 2016 / Granada, Spain PARQUE DE LAS CIENCIAS PROGRAM International symposium on LIQUID BIOPSIES 2016 will provide a platform for presentations, discussions and planning across all aspect
LIVER PATHOLOGY. Thursday 28 th November 2013
LIVER PATHOLOGY Thursday 28 th November 2013 Liver biopsy assessment of steatosis Amar Paul Dhillon Royal Free Hospital RIBA, London Thursday 28th November 2013 NAFLD didn t exist before 2001 and liver
NAFLD: US GUIDELINES. US Guidelines for NAFLD
NAFLD: US GUIDELINES Arun J Sanyal M.D. Charles Caravati Professor of Medicine Virginia Commonwealth University School of Medicine US Guidelines for NAFLD Represents consensus amongst AGA, AASLD and ACG
Non-Alcoholic Fatty Liver Disease
Non-Alcoholic Fatty Liver Disease None Disclosures Arslan Kahloon M.D Chief, Division of Gastroenterology and Hepatology University of Tennessee College of Medicine Chattanooga Objectives Understand the
Dietary supplementation in treating non-alcoholic fatty liver disease Dr. Ahmad Saedi Associate Professor School of Nutritional Sciences and
Dietary supplementation in treating non-alcoholic fatty liver disease Dr. Ahmad Saedi Associate Professor School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Honorary Academic
The Absence of Obstructive Sleep Apnea May Protect against Non- Alcoholic Fatty Liver in Patients Undergoing Bariatric Surgery
The Absence of Obstructive Sleep Apnea May Protect against Non- Alcoholic Fatty Liver in Patients Undergoing Bariatric Surgery The Harvard community has made this article openly available. Please share
Hepatitis C Eradication Reduces Liver Decompensation, HIV progression, and Death in HIV/HCV-coinfected Patients with non-advanced Liver Fibrosis
Hepatitis C Eradication Reduces Liver Decompensation, HIV progression, and Death in HIV/HCV-coinfected Patients with non-advanced Liver Fibrosis J. Berenguer 1, F. X. Zamora 2, C. Díez 1, M. Crespo 3,
Organized by. Scientific comittee
July 11 & 12, 2019 Institut Pasteur Organized by Arun Sanyal Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Lawrence Serfaty Hôpital Hautepierre Hôpitaux Universitaires de
NON-ALCOHOLIC FATTY LIVER DISEASE:
NON-ALCOHOLIC FATTY LIVER DISEASE: ROLE OF THE PRIMARY PROVIDER Archita P. Desai, MD Assistant Professor of Medicine University of Arizona 25 th Annual Southwestern Conference on Medicine Outline Pathophysiology
EASL EASD EASO Clinical practice guidelines for the management of nonalcoholic fatty liver disease.
Commentary. EASL EASD EASO Clinical practice guidelines for the management of nonalcoholic fatty liver disease. Christopher D. Byrne 1,2, Giovanni Targher 3 1 Nutrition and Metabolism, Faculty of Medicine,
LIVER, PANCREAS, AND BILIARY TRACT
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2012;10:1028 1033 LIVER, PANCREAS, AND BILIARY TRACT Prevalence and Indicators of Portal Hypertension in Patients With Nonalcoholic Fatty Liver Disease FLAVIA D.
Non-Alcoholic Fatty Liver Disease (NAFLD)
HEPATO-PANCREATO-BILIARY STOMACH CANCER PROGRAM Non-Alcoholic Fatty Liver Disease (NAFLD) Steatosis and Non-Alcoholic Steatohepatitis (NASH) Management Recommendations UCSF Fresno Department of Surgery
Evaluation of liver and spleen stiffness using a ultrasound guided method: Accuracy of ARFI(R) measurements in liver disease patients
Evaluation of liver and spleen stiffness using a ultrasound guided method: Accuracy of ARFI(R) measurements in liver disease patients Poster No.: C-3242 Congress: ECR 2010 Type: Topic: Authors: Keywords:
Conflicts of Interest in the last 12 months
STEATOHEPATITIS Richard K. Sterling, MD, MSc, FACP, FACG VCU Hepatology Professor of Medicine Chief, Section of Hepatology Virginia Commonwealth University Richmond, VA Conflicts of Interest in the last
Personalised medicine with state-of-the-art MR image analysis
Personalised medicine with state-of-the-art MR image analysis Biomarkers as tests Diagnostic pathways in chronic disease Heart failure EKG BNP Echo/cardiac MRI COPD CXR Pulmonary function tests Chest CT
NAFLD & NASH. Naga Chalasani, MD, FACG Professor of Medicine and Cellular & Integrative Physiology Director, Division of GI and Hepatology
NAFLD & NASH Naga Chalasani, MD, FACG Professor of Medicine and Cellular & Integrative Physiology Director, Division of GI and Hepatology Indiana University School of Medicine ACG Midwest Regional Course,
Fatty Liver- how important is it? Jeremy F.L. Cobbold MA PhD MRCP Clinical Lecturer in Hepatology Imperial College London
Fatty Liver- how important is it? Jeremy F.L. Cobbold MA PhD MRCP Clinical Lecturer in Hepatology Imperial College London Fatty liver- how important is it? Importance in terms of: Prevalence Pathogenesis
NICE guideline Published: 6 July 2016 nice.org.uk/guidance/ng49
Non-alcoholic fatty liver disease (NAFLD): assessment and management NICE guideline Published: 6 July 20 nice.org.uk/guidance/ng49 NICE 2017. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-ofrights).
Improved Hepatic Fibrosis Grading Using Point Shear Wave Elastography and Machine Learning
Improved Hepatic Fibrosis Grading Using Point Shear Wave Elastography and Machine Learning Presenter: Hersh Sagreiya 1, M.D. Authors: Alireza Akhbardeh 1, Ph.D., Isabelle Durot 1, M.D., Carlo Filice 2,
Principals of Kinetic Measures of Liver Function
Principals of Kinetic Measures of Liver Function Focus on the Dual Cholate Clearance Test (HepQuant SHUNT)* Gregory T. Everson, MD Professor of Medicine Director of Hepatology University of Colorado Denver
Clinical Trials & Endpoints in NASH Cirrhosis
Clinical Trials & Endpoints in NASH Cirrhosis April 25, 2018 Peter G. Traber, MD CEO & CMO, Galectin Therapeutics 2018 Galectin Therapeutics NASDAQ: GALT For more information, see galectintherapeutics.com
What Are the Targets in CKD-MBD?
Knowledge Exchange 2016 Paris, France, September 30, 2016 Date of preparation: Nov 2016 Item job code: INTSP/C-ANPROM/FOS/16/0025 Cristina Ortiz Jorge B Cannata-Andía Bone and Mineral Research Unit Hospital
Nonalcoholic fatty liver disease (NAFLD) is the most common
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2008;6:1249 1254 Cytokeratin 18 Fragment Levels as a Noninvasive Biomarker for Nonalcoholic Steatohepatitis in Bariatric Surgery Patients DIMA L. DIAB,* LISA YERIAN,
Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease
1 Liver Unit, Newcastle Upon Tyne Hospitals NHS Trust, Freeman Hospital, Newcastle upon Tyne, UK 2 Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne,
Fatty Liver in HIV. Richard K. Sterling, MD, MSc, FACP, FACG
Fatty Liver in HIV Richard K. Sterling, MD, MSc, FACP, FACG Professor of Medicine Chief, Section of Hepatology Director, HIV-Liver Disease Virginia Commonwealth University Liver-Related Deaths in HIV 1246
Obesity, Inflammation and Liver Cancer
Obesity, Inflammation and Liver Cancer Richard Moreau, M.D., 1 INSERM U773, Centre de Recherche Biomédicale Bichat-Beaujon CRB3, 2 Université Denis Diderot Paris 7, 3 Service d Hépatologie, Hôpital Beaujon,
IL METABOLISMO EPATICO DEI CARBOIDRATI IN FISIOLOGIA E PATOLOGIA
UNIGASTRO Il fegato come centrale metabolica e i fattori di danno oltre ai virus epatitici IL METABOLISMO EPATICO DEI CARBOIDRATI IN FISIOLOGIA E PATOLOGIA Dr Elisabetta Bugianesi Divisione di Gastro-Epatologia
Liver Fat Quantification
Liver Fat Quantification Jie Deng, PhD, DABMP Department of Medical Imaging May 18 th, 2017 Disclosure Research agreement with Siemens Medical Solutions 2 Background Non-alcoholic fatty liver diseases
Screening cardiac patients for advanced liver disease
HKASLD 30 th ASM and International Symposium on Hepatology 2017 Screening cardiac patients for advanced liver disease 5 Nov 2017 Dr. Lau Yue Leung Joulen Pamela Youde Nethersole Eastern Hospital NAFLD
Fatty Liver Disease. Mark Thursz. Imperial College
Fatty Liver Disease Mark Thursz Imperial College Non-Alcoholic Fatty Liver Disease UK adult obesity (BMI>30) 1980: 6% [M], 8% [F]. 1997: 17% [M], 20% [F]. By 2004, 23.6% of men and 23.8% of women were
Defining the gold standard in biomarker validation for NASH
Defining the gold standard in biomarker validation for NASH Arun J Sanyal M.D. Professor of Medicine, Physiology and Molecular Pathology Virginia Commonwealth University School of Medicine Conflicts of
NON-ALCOHOLIC STEATOHEPATITIS AND NON-ALCOHOLIC FATTY LIVER DISEASES
NON-ALCOHOLIC STEATOHEPATITIS AND NON-ALCOHOLIC FATTY LIVER DISEASES Preface Zobair M. Younossi xiii Epidemiology and Natural History of NAFLD and NASH 1 Janus P. Ong and Zobair M. Younossi Understanding
H. Collins, G. Beban, J. Windsor, R. Ram, N. Evennett, B. Loveday Auckland City Hospital, Auckland, New Zealand
UTILITY AND SAFETY OF ROUTINE LIVER BIOPSY DURING BARIATRIC SURGERY H. Collins, G. Beban, J. Windsor, R. Ram, N. Evennett, B. Loveday Auckland City Hospital, Auckland, New Zealand BACKGROUND Prevalence
ENCORE-PH Top-line Results
ENCORE-PH Top-line Results Striving to improve human health December 5, 2018 NASDAQ CNAT Forward-looking Statements This presentation contains forward-looking statements. All statements other than statements
«STEATOSI EPATICA ED EPATOPATIE METABOLICHE» Ester Vanni Division of Gastroenterology University of Turin
«STEATOSI EPATICA ED EPATOPATIE METABOLICHE» Ester Vanni Division of Gastroenterology University of Turin OUTLINE NAFLD overview NAFLD and menarche NAFLD and pregnancy NAFLD and menopause Other metabolic
3. (((fatty or fat or steato*) adj3 (liver* or hepat*)) or steatohepat* or (visceral adj2 steato*)).ti,ab
Search strategy for MEDLINE Steatosis: 1. fatty liver/ 2. non-alcoholic fatty liver disease/ 3. (((fatty or fat or steato*) adj3 (liver* or hepat*)) or steatohepat* or (visceral adj2 steato*)).ti,ab 4.
Noninvasive Techniques for the Evaluation and Monitoring of Patients With Chronic Liver Disease
Noninvasive Techniques for the Evaluation and Monitoring of Patients With Chronic Liver Disease Policy Number: 2.04.41 Last Review: 2/2019 Origination: 2/2017 Next Review: 2/2020 Policy Blue Cross and
WHAT CAN YOU USE IN YOUR CLINIC TODAY FOR THE TREATMENT OF NASH?
WHAT CAN YOU USE IN YOUR CLINIC TODAY FOR THE TREATMENT OF NASH? Helena Cortez-Pinto Laboratório de Nutrição, FML, Serviço de Gastrenterologia, Hospital St Maria, Lisboa, Portugal EASL Governing Board: