The Role of the Pharmacist in Postoperative Pain Management: Strategies to Help Combat the Epidemic
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1 The Role of the Pharmacist in Postoperative Pain Management: Strategies to Help Combat the Epidemic Presented By: Cheryl Genord, R.Ph. B.S.Pharm Clinical Pharmacy Specialist
2 Learning Objectives Describe how opioids prescribe for acute postoperative pain has contributed to the opioid epidemic. Identify strategies used for successful and safe discontinuation of prescription opioid following surgery
3 The Opioid Epidemic 3
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8 SOURCE: National Center for Health Statistics, National Vital Statistics System, mortality data ( SUGGESTED CITATION: Rossen LM, Bastian B, Warner M, Khan D, Chong Y. Drug poisoning mortality: United States, National Center for Health Statistics (Available from:
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10 Opioid Use Disorders in Michigan 2015 Overdose Deaths In Michigan 1257
11 Michigan 2016 County RX per 100 pts RX per 100 pts RX % Increase since 2006 Calhoun % Grand Traverse % Ingham % Iosco % Kalamazoo % Kent % Mason % Muskegon % Newaygo % Ostego % Van Burren % In 2016, 11 million RX written for opioid 1.1 RX or 84 pills for every Michigan resident.
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13 How did post-operative prescribing help fuel the opioid epidemic 13
14 Discharge Prescriptions Pain control is essential to recovery Decrease Length of Stay and effort to accelerate post op recovery Increase in Ambulatory Surgeries Pharmaceutical companies marketing opioids for surgical pain with little concern for addiction or persistent opioid use Maximize patient satisfaction/ Decrease work for office staff / physician OVER PRESCRIBING
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16 Overprescribing & No guidance on opioids New Persistent opioid use Increase opioids in reservoir Possibility of withdrawal after use of opioids for acute pain Substance Use Disorders 16
17 From: Incidence of and Risk Factors for Chronic Opioid Use Among Opioid-Naive Patients in the Postoperative Period JAMA Intern Med. 2016;176(9): doi: /jamainternmed Date of download: 4/11/2018 Copyright 2016 American Medical Association. All rights reserved.
18 From: Incidence of and Risk Factors for Chronic Opioid Use Among Opioid-Naive Patients in the Postoperative Period JAMA Intern Med. 2016;176(9): doi: /jamainternmed Date of download: 4/11/2018 Copyright 2016 American Medical Association. All rights reserved.
19 Risk factors associated with persistent opioid use Preoperative tobacco use Alcohol or Substance Use Disorder Mood disorders Anxiety Preoperative pain disorder: Back pain Neck pain Arthritis Centralized pain 19
20 20
21 Overprescribing & No guidance on opioids New Persistent opioid use Increase opioids in reservoir Possibility of withdrawal after use of opioids for acute pain Substance Use Disorders 21
22 Systemic review of 6 studies 810 patients Surgeries: orthopedic, thoracic, obstetric, and general surgical procedures 67-92% Pts reported unused opioids 42-71% Opioid tablets that went unused 75% Did not store opioids safely 4-30% Plan to dispose of opioids
23 Medication Sharing, Storage, and Disposal Practices for Opioid Medications Among US Adults From: Medication Sharing, Storage, and Disposal Practices for Opioid Medications Among US Adults JAMA Intern Med. 2016;176(7): Copyright 2016 American Medical Association. All rights reserved. JAMA Intern Med. Published online June 13, doi: /jamainternmed
24 In the US, 5.3M young adults had SUDs in 2015; 15.3% or 1 in 7 young adults Source: 2015 National Surgery on Drug Use and Abuse
25 Survey 1151 young adults Results obtained were statistically valid (95% confidence level) to +/- 2.8%
26 70 Source of prescription Opioids Among Past-Year Non-Medical Users Chart Title Any Given by a friend or relative for free Prescribed by physician(s) Stolen from a friend or relative Bought from a friend or relative Bought from a drug dealer or other stranger Other Jones JAMA Internal Medicine May 2014 Volume 174, Number 5
27 Overprescribing & No guidance on opioids New Persistent opioid use Increase opioids in reservoir Possibility of withdrawal after use of opioids for acute pain Substance Use Disorders 27
28 Patient on epidural Fentanyl infusion after surgery at 24mcg/hr. PS>3 4 hr after DC pt experienced agitation, restlessness, profuse sweating, muscle aches BP 170/110 and HR was 105 Pt receive fentanyl 50mcg IVx2 - signs of withdrawal improved Epidural was tapered down gradually over 12 hours by reducing rate 6 mcg/hr every 3 hours. Symptoms did not return
29 68 year old consulting firm president had 9 hour back surgery. Outpatient RX: Hydromorphone 2 tab q4hprn- which she took close to full dose for 2 weeks about 28mg/day = about 75mg oxycodone/day Received no guidance on tapering off Hydromorphone. She tapered off herself and went into withdrawal nervousness, nausea, diarrhea, vomiting, muscle pains, headache, Surgeon and PCP did not recognize her symptoms as withdrawals
30 Downward Spiral of not recognizing withdrawal after hospital discharge Patient has surgery and discharged with oxycodone Patient has significant pain and uses oxycodone After the pain began to subside and non-opioid are sufficient. Stops using the oxycodone. But after discontinuing the oxycodone, patient reports feeling terrible, experiencing body aches, restlessness, and insomnia. Takes another oxycodone and feels better. Continued treating withdrawal systems with oxycodone, versus using it for pain. Don t want to stop taking opioids, even after pain subsides
31 Overprescribing & No guidance on opioids New Persistent opioid use Increase opioids in reservoir Possibility of withdrawal after use of opioids for acute pain Substance Use Disorders 31
32 Michigan-OPEN (Opioid prescribing engagement network) 32
33 Chronic Opioid Use/Opioid Diversion DECREASE RESERVOIR Decrease the amount of opioids dispensed. Decrease the amount of opioids consumed. Increase the amount of opioids destroyed 33
34 Strategies used for opioid de-escalation Provider Based Multimodal analgesia Guidelines Patient Based Education on Tailor prescribing to individualized patient s utilization Procedure Based Evidence based prescribing by surgery 34
35 Multi-modal Strategies Pre-op Intra-op Post-op Decrease/minimize preop opioids Ketorolac, Ketamine, etc. Cryotherapyice, cooler, wrap Set Expectations Pain is part of recovery process Brief opioid education Field block or regional block Cognitive Behavioral Therapy, Meditation Offer self-management strategies: Meditation, Music, Aromatherapy, Personal coping strategies 2015 CAM music, aroma, distraction, healing touch Weaning strategy Discharge instructions, wean by MME 35
36 Multimodal Therapy Short Acting Opioids NSAIDs and APAP Anticonvulsants NO Sedatives hypnotics Least amount of weeks possible Most surgeries 1 week To Pain Management or Addiction Specialist if can t ween NO Extended Release/Long Acting Opioids Order as scheduled not prn Administer 4 times daily and give at same time. For Neuropathic pain Benzos, Ambien 36
37 Probability of Opioid Prescription Refilling After Surgery: Does Initial Prescription Dose Matter? Refills: Quantity does not predict Refills N=26,520 Optum Insight Clims data Sekhri S, Arora NS, Cottrell H, Baerg T, Duncan A, Hu HM, Englesbe MJ, Brummett C, Waljee JF, Ann Surg
38 Probability of Opioid Prescription Refilling After Surgery: Does Initial Prescription Dose Matter? No, then what did matter? Patient factors correlated with the probability of refill: tobacco use [odds ratio (OR) 1.42, 95% confidence interval (CI) ] anxiety (OR 1.30, 95% CI ) mood disorders (OR % CI ) alcohol or SUD (OR 1.43, 95% CI ) arthritis (OR 1.21, 95% CI )
39 Patient Satisfaction: HCAHPS Prescribing Lee JS, Hu HM, Brummett CM, Syrjamaki JD, Dupree JM, Englesbe MJ, Waljee JF. JAMA May 16, 2017
40 Pharmacy Initiatives on Provider-Based Strategies Develop multimodal pain management in the hospital AND when patients are discharge Education of Clinicians on multimodal therapy and opioids reductions
41 Strategies used for opioid de-escalation Provider Based Multimodal analgesia Guidelines Patient Based Education on Tailor prescribing to individualized patient s utilization Procedure Based Evidence based prescribing by surgery Add Shared Decision Making 41
42 Department of defense military health system opioid naïve patient for 8 common surgeries Over 200,000 patients mean prescription length Surgery Appendectomy and cholecystectomy Inguinal Hernia Repair Hysterectomy Mastectomy ACL repair and Rotator Cuff repair Discectomy Median Presciption Length 4 days 5 days 4 days 5 days 5 days 7 days
43 Laparoscopic Cholecystectomy 43
44 44
45 45
46 Michigan-OPEN recommendations 46
47 N=51 Received education about expected pain, treatment options and adverse effects of options. Patients decided how many oxycodone tablets they wanted 0-40 tablets 47
48 Pharmacy Initiatives on Procedure-Based Strategies Help standardize opioid amount prescribed Share Decision Making Intervention
49 Strategies used for opioid de-escalation Provider Based Multimodal analgesia Guidelines Patient Based Education on tailor prescribing to individualized patient s utilization Procedure Based Evidence based prescribing by surgery Add Shared Decision Making 49
50 Development/Counseling on a Opioid Exit Plan Multimodal FIRST non opioids and nonpharmacologics Opioid Taper Physician support and commitment Side Effects and treatment Safe Storage and Disposal of opioids
51 51
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54 Opioid Taper Regimens - Standard Taper for specific surgery GYN Laparoscopic Hysterectomy #15 oxycodone for 4 days Multimodal base - Schedule: APAP; NSAIDs etc. Non medication: Ice, heat, rest, exercise, etc. Oxycodone taper: Day 1: 1-2 tabs q6hprn no more than 6 tab per day Day 2: 1 tabs q6hprn no more than 4 tab per day Day 3: 1 tabs q6hprn no more than 3 tab per day Day 4: 1 tabs q6hprn no more than 2 tab per day 54
55 Standard GYN Exit Plan
56 Opioid Taper Regimen Individualize taper for more complicated patient and/or surgery Multimodal base scheduled non-opioids APAP, NSAIDS, Adjuvants, Muscle Relaxants, etc. Non medication: Ice, heat, rest, exercise, etc. Calculate last 24 hours opioid requirement prior to discharge. Base the drug, dose, and amount of opioids prescribed at discharge on this requirement. Individualize a taper from this prescription based on how long the pain usually last from this surgery. 56
57 Individualized Taper: Neurosurgery expected to have pain requiring opioids for 10 days Opioid requirement in last 24 hours prior to discharge: 40mg of oxycodone, administered as 10mg four times. Oxycodone 5mg 1-2 tabs q6h prn #50 Day 1-2 Day tabs q6h prn up to 8 tabs per day 1-2 tab q6h prn up to 6 tabs per day Day tab q6h prn - up to 4 tabs per day Day tab q6h prn - up to 2 tabs per day 57
58 Individualized Exit Plan
59 Post discharge ambulatory clinic Assessment Pain Dehydration Ileus Surgical Site Infection Goals: Decrease readmits Decrease ER visits Adherence to Opioid Exit plan
60 Encourage Opioid Disposal Police Stations and Big Red Barrel National Take Back Days April and October Opioid Disposal Systems 60
61 Opioid Disposal System Program Given free to every St. Joseph Ann Arbor, Chelsea, and Livingston patient who has an acute pain opioid prescription. 61
62 Pharmacy Initiatives on Patient Based Strategies Development of Post-surgical pain discharge plan Patient education of the Post surgical discharge plan Multimodal pain management Opioid exit plan Involvement in Ambulatory Post discharge clinic Encourage opioid disposal
63 Questions? 63
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