Prescribing Perils including - drugs of dependence RACGP Conference - September 2015
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1 Prescribing Perils including - drugs of dependence RACGP Conference - September 2015 Dr Greg Whelan AM MD, MBBS MSc., FRACP, FAFPHM, FAChAM Senior Medical Advisor, Avant Insurance Dr Owen Bradfield MBBS(Hons), BMedSc(Hons), LLB, MBA, FACLM Senior Claims Manager & Medical Advisor, Avant Insurance Background > Most medical practitioners especially GPs prescribe medications during each consulting session > A prescription is a legal document with the prescriber taking legal responsibility for its content > You should have a clear clinical indication for prescribing irrespective whether another doctor has previously written a prescription for that medication Adverse events > Adverse events from prescribing can result in problems for the patient and the prescriber > Problems for the prescriber can result in a visit to the coroner s court, a disciplinary body (AHPRA) or civil proceedings Prescribing errors > Prescribing errors are common, most can be avoided by adhering to good system protocols 1
2 Complaints due to adverse events that result from prescribing > Drug side-effects > Drug interactions > Wrong person > Wrong drug > Wrong dose 3 Legal requirements A brief overview 4 2
3 How do I know what is a Schedule 8 poison? > Poisons Standard 2015 Pursuant to Paragraph 52D(2)(b) of the Therapeutic Goods Act 1989 (Cth) Requirements for Schedule 8 prescribing > Each State and territory has separate legislation State Legislation ACT Medicines, Poisons and Therapeutic Goods Act 2008 New South Wales Poisons and Therapeutic Goods Act 1966 Northern Territory Medicines, Poisons and Therapeutic Goods Act 2008 Queensland Health (Drugs and Poisons) Regulations 1996 South Australia Controlled Substances Act 1984 Tasmania Poisons Act 1971 Victoria Drugs, Poisons and Controlled Substances Act 1981 Western Australia Poisons Regulations
4 Requirements for Schedule 8 prescribing > Victoria as an example Requirements for Schedule 8 permit > MUST apply for a permit BEFORE prescribing to a drug-dependent person BEFORE prescribing any of the following*: Methadone; or Dexamphetamine; or Methylphenidate. BEFORE prescribing for more than 8 weeks duration in other circumstances *Must be an authorised prescriber 4
5 Exceptions to these requirements > Exceptions: Treatment of cancer-related pain Treatment in a residential aged care facility Consequences of not complying with legislation >Liable to prosecution Uncommon unless repeated breaches despite warnings Unable to reasonably justify breaches 5
6 Writing prescriptions >The doctor writing the prescription assumes responsibility for the prescription and its compliance with legislation Irrespective of whether another doctor at the practice primarily prescribes; or specialist has recommended the treatment >Prescribe only for the medical treatment of patients under your care (regulation 8) Other requirements >Need to establish that a genuine therapeutic need exists Beware of: new patients unconvincing stories drugs commonly targeted by drug-seekers patients asking for private scripts >Need to establish the identity of the patient 6
7 Notification of drug-dependent person Section 33 > Doctor must notify Secretary of Department of Health When a medical practitioner has reason to believe a person is drug-dependent and the person is seeking a drug of dependence NB. Privacy legislation does not consider this to be a breach of the patient s privacy Self-administration Regulation 48 > Doctor must not use, prescribe, sell or supply a Schedule 4 poison, a Schedule 8 poison or a Schedule 9 poison (as the case requires) for the purpose of self-administration 7
8 Documentation Section 32 Drugs, Poisons, Controlled Substances Act 1981 (Vic) Record keeping in relation to sale or supply of drugs of addiction (1) A person who is licensed under this Part to manufacture, sell, supply or distribute any Schedule 8 poison or Schedule 9 poison must record or cause to be recorded, in accordance with subsection (2) (a) details of any Schedule 8 poison or Schedule 9 poison obtained by the person; and (b) quantities of those poisons used, sold, supplied or otherwise disposed of; and (c) such other particulars as are prescribed. 60 penalty units Documentation (cont) Requirement to keep records of destruction: > Regulation 40(1)(f) requires medical practitioner to record: name, strength and quantity of Schedule 8 poison destroyed; and place and method of destruction; and the name of the person carrying out the destruction; and names of any witnesses. 8
9 Destruction of Schedule 8 poisons Wilful destruction of Schedule 8 poisons prohibited unless: > Regulation 51(3) - destroyed in the presence of another registered health practitioner. > Regulation 40(1)(f) records retained Coronial investigations Coroner is increasingly taking an interest in deaths associated with prescription of Schedule 8 medications: > Did you contact the patient s previous prescriber before prescribing [Schedule 8 medication] for this patient? > Were you aware that this patient was engaged in prescription shopping for a range of benzodiazepines? > Were you aware that this patient was receiving opioid replacement therapy at another clinic? > Did you ever contact the Prescription Shopping Information Service or the Department of Health regarding this patient? 9
10 Useful resources > Each State and territory Department of Health has guidelines State ACT New South Wales Northern Territory Queensland South Australia Tasmania Victoria Western Australia Legislation ACT Health: NSW Ministry of Health: Northern Territory Department of Health: edical_practitioners/index.aspx Queensland Health: SA Health: nical+resources/clinical+topics/medicines+and+drugs/drugs+of+dependence Tasmania Department of Health and Human Services: Victorian Department of Health & Human Services: Western Australia Department of Health: medici nes.pm 4 cases for discussion Each group should select a person to present briefly the results of their discussions 20 10
11 Case 1 for discussion 21 Progressive renal failure > A male patient aged 54 treated for insulin dependent diabetes > Presents with severe pain in the distribution of the ophthalmic branch of the facial nerve > He also complains of blurred vision > Examination reveals the beginnings of a rash in this distribution consistent with herpes zoster > Aciclovir 800mg x5 daily orally is prescribed for one week > He next presents with progressive renal failure 11
12 Discussion > What are the issues? > What other information should have been elicited prior to prescribing Aciclovir? > What are the lessons to be learnt? > What could have been done differently? Medico-legal issues: intimate examinations, cultural sensitivities and the use of chaperones 23 Case 2 for discussion 24 12
13 Case 2 wrong patient, wrong drug Visit1 > Female aged 32 presents complaining of tiredness > Apart from heavy periods no relevant history > Apart from pallor no physical signs > FBE arranged Visit 2 > Doctor notes lab result consistent with hypothyroidism > Thyroxine prescribed Visit 3. > Patient still pale and tired but anxious and shaky > Review of file reveals Visit 2 lab results belong to another patient Discussion > What are the issues? > What other information should have been elicited prior to prescribing thyroxine? > What are the lessons to be learnt? > What could have been done differently? Medico-legal issues: intimate examinations, cultural sensitivities and the use of chaperones 26 13
14 Case 3 for discussion 27 Susan aged 38 iatrogenic dependence > Opioids were commenced after a soft tissue injury > Opioids continued following conflict with her supervisor when she returned to work > For months she received prescriptions for opioids and she also used OTC analgesics (codeine) > Depression became a major problem > Her prescriber went on leave and a locum attempted to place a ceiling on her daily dose > Drug withdrawal/craving occurred when drug dosage was reduced 14
15 Discussion > What are the issues? > What other information should have been elicited prior to ongoing prescribing? > What are the lessons to be learnt? > What could have been done differently? Medico-legal issues: intimate examinations, cultural sensitivities and the use of chaperones 29 Case 4 for discussion 30 15
16 Mary iatrogenic benzodiazepine dependence > Mary aged 38 is a single working mother of 3 children. She presents with anxiety symptoms including panic following the death of her mother who regularly assisted with child care. > She is prescribed alprazolam (Xanax) 0.5 mg bd > Over the next few months the dose is increased to 6mg daily for her persistent symptoms. > One day she asks for more or a different drug as she notes they are not working > Last weekend she ran out of tablets, became anxious and began to hallucinate Discussion > What factors are relevant to this problem developing? > Why is she hallucinating? > How could the doctor have responded when they are not working? > What could have been done differently? 32 16
17 Discussion of Cases 33 Background > Opioid Medications Prescriptions for opioid medications for chronic non malignant pain have increased worldwide since long acting formulations were made available > Benzodiazepines Short term use can result in symptom improvement Long term use usually leads to clinical problems > Antipsychotics Prescription volume high. No reliable survey data > Prescription drug toxicity More deaths are caused by these drugs of dependence than by illicit drugs 17
18 Deaths from prescription drugs - Australia Australia Oxycodone deaths rose threefold ( ) 338 deaths* due to drug toxicity in 2010 Victoria Oxycodone deaths rose 21 fold ( ) approx. half unintentional Deaths from prescription drugs - Australia 367* deaths in 2012 Alcohol 30% Illicit drugs 44%, Prescription Drugs 77% deaths Opioids 27% Benzodiazepine 50% *In many deaths more than one drug was involved 36 18
19 How big is the benzodiazepine problem? > Australia Prescriptions for alprazolam increased by 28% ( ). Harm associated led to reclassification as S8, 2014 Non medical use resulted in traffic accidents, aggressive behaviour and withdrawal difficulties 28% increase Long term opioid use > 1 in 4 misuse > 1 in 10 addicted Vowles et al Pain :
20 Importance for prescribers of drugs of dependence Recognition when escalating doses may lead to dependence Recognition and dealing with patients who seek drugs for non medical purposes? Recognition and dealing with patients who have chronic pain but who may be:- Overusing or misusing TIPS IN PRESCRIBING DRUGS OF DEPENDENCE 20
21 What do I tell the patient? What you are prescribing The anticipated benefit The proposed duration of the trial of treatment Discuss alternatives to prescribing a drug of dependence Why you are prescribing The potential risks including dependence How the response will be monitored A monitoring strategy for opioid prescribing > Utilise non medication treatment > Consider an opioid contract the includes semiobjective pain measurement > Review when requests for extra medication. See more frequently Review a behavioural contract Dispense medications at shorter intervals Chemical monitoring urine drug tests Switch to opioid substitution program with supervised dispensing of methadone 42 21
22 Resources > Second opinions Pain management, Addiction medicine, psychiatrist > Drug and Alcohol telephone advisory service > Prescription shopping information service > Department of Health - Drug regulation Group > Voluntary release of patient s PBS prescription details > Good medical practice a code of conduct PRESCRIPTION SHOPPING SERVICE 22
23 Prescription shopping information service doctor shoppers hotline > Phone > Register with the service* > Determine whether your patient is on the list > If your patient is on the list, he is a doctor shopper has seen 6+ doctors in a 3 month period and procured 25+ prescriptions for PBS targeted item This is a high threshold > If your patient is not on the list he may still be a doctor shopper > *the service does not include private scripts, DVA scripts and TAC scripts REAL TIME MONITORING - will this help prevent prescribing problems? 23
24 DOCUMENTATION Summary > Prescribing of opioids is increasing > Non medical use of prescription drugs is increasing > There is no appropriate evidence base for prescribing opioids long term for persistent non malignant pain. > There is no appropriate evidence base for the long term use of benzodiazepines for anxiety disorders > Clinicians need to be able to recognise and manage prescription shoppers and patients requesting/needing drugs of dependence. > Regulation including real time drug monitoring needed 24
25 Important notices General disclaimer The information in this presentation is general information relating to legal and/or clinical issues within Australia (unless otherwise stated). It is not intended to be legal advice and should not be considered as a substitute for obtaining personal legal or other professional advice or proper clinical decision-making having regard to the particular circumstances of the situation. While we endeavour to ensure that documents are as current as possible at the time of preparation, we take no responsibility for matters arising from changed circumstances or information or material which may have become available subsequently. Avant Mutual Group Limited and its subsidiaries will not be liable for any loss or damage, however caused (including through negligence), that may be directly or indirectly suffered by you or anyone else in connection with the use of information provided in this document
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