THURSDAY, SEPTEMBER 20 TH

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1 SCIENTIFIC PROGRAM

2 THURSDAY, SEPTEMBER 20 TH 08:30 08:50 hrs. Welcoming address to the XXIV ALEH CONGRESS 2018 Dr. Fernando Contreras (ALEH President) and Dr. Marlene Perez (Congress President) 08:50 09:00 hrs. Inauguration and welcome speech to the Postgraduate Course: ACHIEVEMENTS AND CHALLENGES OF LATINAMERICAN HEPATOLOGY Dr. Adrián Gadano (Course Director) POSTGRADUATE COURSE: ACHIEVEMENTS AND CHALLENGES OF LATINAMERICAN HEPATOLOGY Director: Dr. Adrián Gadano Secretary: Sebastián Marciano MODULE I BACTERIAL INFECTION IN CIRRHOTIC PATIENTS 09:00 09:20 hrs. Epidemiology of bacterial infections in cirrhotic patients in Latin America Dr. Angelo Matos (Brazil) 09:20 09:40 hrs. Pathophysiology of bacterial infections in cirrhotic patients Dr. Richard Moreau (France) 09:40 10:00 hrs. Diagnosis and treatment of bacterial infections in cirrhotic patients Dr. Agustin Albillos (Spain) 10:00 10:20 hrs. Discussion: Questions & Answers 10:20 10:50 hrs. COFFEE BREAK MODULE II CRITICAL SCENARIOS IN CIRRHOTIC PATIENTS 10:50 11:10 hrs. Treatment for GI bleeding due to portal hypertension in cirrhotic patients Dr. Andrés Cardenas (Spain) 11:10 11:30 hrs. Acute Kidney Injury in cirrhotic patients Dr. Paolo Angeli (Italy) 11:30 11:50 hrs. Acute-on-chronic liver failure: Definition and clinical presentation Dr. Richard Moreau (France) 11:50 12:10 hrs. Discussion: Questions & Answers MODULE III HEPATOCELLULAR CARCINOMA 12:10 12:30 hrs. Hepatocellular carcinoma epidemiology in Latin America Dr. Flair Carrilho (Brazil) 12:30 12:50 hrs. Curative treatment for hepatocellular carcinoma Dr. Federico Piñero (Argentina)

3 12:50 13:10 hrs. Treatment for intermediate and advanced hepatocellular carcinoma Dr. Roberto Leon (Venezuela) 13:10 13:30 hrs. Discussion: Questions & Answers 13:30 14:50 hrs. INDUSTRY SYMPOSIUM HCV (Lunch Box) MODULE IV NON-ALCOHOLIC FATTY LIVER DISEASE 15:00 15:20 hrs. Epidemiology of non-alcoholic fatty liver disease in Latin America Dr. Nahúm Méndez (Mexico) 15:20 15:40 hrs. Pathophysiology of non-alcoholic fatty liver disease Dr. Helena Cortez Pinto (Portugal) 15:40 16:00 hrs. Non-pharmacologic treatment of patients with non-alcoholic fatty liver disease Dr. Marco Arrese (Chile) 16:00 16:20 hrs. Drugs in development for treatment of non-alcoholic fatty liver disease Dr. Aarun Sanyal (USA) 16:20 16:40 Discussion: Questions & Answers 16:40 17:00 hrs. COFFEE BREAK MODULE V VIRAL HEPATITIS 17:00 17:20 hrs. Epidemiology of Hepatitis B in Latin America Dr. Hugo Cheinquer (Brazil) 17:20 17:40 hrs. Staging and current treatment for chronic Hepatitis B Dr. Jose Luis Calleja (Spain) 17:40 18:00 hrs. Epidemiology and diagnosis of Hepatitis E in Latin America Dr. Raymundo Paraná (Brazil) 18:00 18:20 hrs. Acute liver failure Dr. Mario Pessoa (Brazil) 18:20 18:40 Discussion: Questions & Answers FINAL CONFERENCE IN POSTGRADUATE COURSE 18:50 hrs. Current state of Hepatitis C in Latin America. Dr. Marcelo Silva (Argentina) 19:30 20:00 hrs. CONGRESS OPENING CEREMONY

4 FRIDAY, SEPTEMEBER 21 ST 07:00 07:45 hrs. Breakfast with the Expert (25 people max, 25 USD) Room 1: Treatment with DAA in coinfected patients Dr. Richard Sterling (USA) Room 2: Indications for hepatic biopsy in patients with NAFLD Dr. Aarun Sanyal (USA) Room 3: Resistance to DAA. When to test? Dr. Marcelo Silva (Argentina) Room 4: Correct use of albumin in cirrhotic patients Dr. Paolo Angeli (Italy) VIRAL HEPATITIS MODULES - PLENARY SESSION (Room A and B) HEPATITIS C SESSION 08:00-08:20 hrs. Genotype 1 treatment in 2018 Dr. José Luis Calleja (Spain) 08:20-08:40 hrs. Treatments for genotypes 2 and 3 Dr. Michael Fried (USA) 08:40-09:00 hrs. Treatment in special populations (CKD, decompensated patients) Dr. Michael Curry (USA) 09:00-09:20 hrs. Access to treatment: Challenges and strategies in Latin America Dr. David Kersenovich (Mexico) 09:20-09:40 hrs. Case presentation Dr. Juan Carlos Restrepo (Colombia) 09:40-10:00 hrs. Questions & Answers 10:00-10:30 hrs. COFFEE BREAK HEPATITIS B SESSION 10:30 10:50 hrs. New therapeutic options for Hepatitis B in Can we eradicate cccdna? Dr. Anna Lok (USA) 10:50 11:10 hrs. When to stop NUCs treatment? Dr. Adrian Gadano (Argentina)

5 11:10 11:30 hrs. Hepatitis B reactivation Dr. David Bernstein (USA) 11:30 11:50 hrs. Hepatitis Delta. Where do we stand today? Dr. Javier Brahm (Chile) 11:50 12:10 hrs. Case presentation (1 case) Dr. Javier Diaz Ferrer (Peru) 12:10 12:30 hrs. Questions & Answers 12:30 13:30 hrs. ORAL COMMUNICATIONS 13:30 14:30 hrs. INDUSTRY SIMPOSSIUM/LUNCH BREAK SIMULTANEOUS EVENING SESSIONS ALEH-EASL SIMPOSSIUM (Room A) 15:00-15:20 hrs. EASL NAFLD CPGs Dr. Helena Cortez Pinto (Portugal) 15:20-15:40 hrs. Emerging therapies for NAFLD Dr. Helena Cortez Pinto (Portugal) 15:40-16:00 hrs. EASL CPGs on autoimmune and cholestatic liver disease Dr. Tom Hemming Karlsen (Norway) 16:00-16:20 hrs. Trends in liver research: the gut-liver axis Dr. Tom Hemming Karlsen (Norway) 16:20-17:00 hrs. ALEH case presentation ALEH YI Dr. Manuel Mendizabal (Argentina) Case discussion ALEH Chair Dr. Adrian Gadano/EASL ChairALEH Case presentation ALEH YI: Dr. Sebastian Diaz Ramirez (Colombia) Case discussion ALEH Chair: Dr. Alejandra Villamil/EASL Chair 17:00-17:30 hrs. COFFEE BREAK 17:30 18:30 hrs. INDUSTRY SIMPOSSIUM LIVER AND ENDOSCOPY - ALEH-ASGE (Room B) 15:00-15:20 hrs. Pre-anesthesia evaluation sedation of patients with advanced hepatic disease Dr. Rolando Ortega (Colombia) 15:20-15:40 hrs. Treatment of GI bleeding due to esophageal varices Dr. Agustin Albillos (España)

6 15:40-16:00 hrs. Coagulation treatment prior to endoscopy and new anticoagulation medication. What to do? Dr. Arturo Ballestero (Mexico) 16:00-16:20 hrs. Endoscopic management of post-hepatic transplant biliary complication Dr. Andres Cardenas (Spain) 16:20-16:40 hrs. Endoscopic treatment for Primary Sclerosing Cholangitis Dr. Andres Gelrud (Venezuela) 16:40-17:00 hrs. Case presentation. Q&A session Dr. Leon de Metzerville (Costa Rica) 17:00-17:30 hrs. COFFEE BREAK 17:30-18:30 hrs. INDUSTRY SIMPOSSIUM MISCELANEOUS MODULE (Room C) 15:00 15:20 hrs. Hepatitis E: Impact in Latin America Dr. Raymundo Parana (Brazil) 15:20 15:40 hrs. Non-invasive physical methods for hepatic fibrosis Dr. Jose Luis Callejas (Spain) 15:40 16:00 hrs. ACLF: Prognosis and treatment Dr. Paolo Angeli (Italy) 16:00 16:20 hrs. Biological methods for fibrosis determination Dr. Rene Male (Mexico) 16:20 16:40 hrs. Case presentation Dr. Graciela Castro (Mexico) 16:40 17:00 hrs. Questions & Answers 17:00-17:30 hrs. COFFEE BREAK 17:30-18:30 hrs. INDUSTRY SIMPOSSIUM 18:30 hrs. ALEH ASSEMBLY: BOARD, REPRESENTATIVES OF MEMBER COUNTRIES, ALEH PERMANENT COUNCIL

7 SATURDAY, SEPTEMBER 22 ND 07:00 7:45 hrs. BREAKFAST WITH THE EXPERT (Max 25 people, 25 dollars) Room 1: Minimal hepatic encephalopathy: Diagnosis and treatment Dr. Aldo Torre Mexico Room 2: Cardiovascular risk in patients with NASH Dr. Martin Tagle (Peru) Room 3: Hepatitis B treatment in special populations (CKD) Dr. Anna Lok (USA) Room 4: Treatment of acute Hepatitis C in the DAA era Dr. David Berntein (USA) CIRRHOSIS AND ITS COMPLICATIONS PLENARY SESSION (Rooms A and B) 08:00 08:20 hrs. Natural history of hepatic cirrhosis Dr. Guadalupe Garcia-Tsao (Mexico-USA) 08:20 08:40 hrs. Sepsis in the cirrhotic patient Dr. Agustin Albillos (Spain) 08:40 09:00 hrs. Measuring portal pressure in cirrhosis Dr. Guadalupe Garcia Tsao (Mexico) 09:00 09:20 hrs. Management of ascitis and CKD in cirrhotic patients Dr. Paolo Angeli (Italy) 09:20 09:40 hrs. Case presentation Dr. Mirta Castro (Cuba) 09:40 09:50 hrs. Questions & Answers 09:50 10:20 hrs. COFFEE BREAK 10:20 10:40 hrs. Portal thrombosis in cirrhosis: anticoagulation approach Dr. Juan G Abraldes (Canada) 10:40 11:00 hrs. Beta-blockers: indications, contraindications and risks Dr. Richard Moreau (France) 11:00 11:20 hrs. TIPS: indications and complications Dr. Juan G Abraldes (Canada)

8 11:20 11:40 hrs. Management of hepatic encephalopathy Dr. Jorge Luis Poo (Mexico) 11:40 12:00 hrs.. Case presentation Dr. Esteban Ruiz (Costa Rica) 12:00 12:10 hrs. Questions & Answers 12:15 13:15 hrs. ORAL COMMUNICATIONS 13:30 14:30 hrs. INDUSTRY SIMPOSSIUM/LUNCH BREAK ALEH-AASLD RESEARCH WORKSHOP 2018 COURSE DIRECTORS: ANDRÉS CARDENAS AND RAY KIM 08:05-8:10 hrs. Introduction Dr. Ray Kim & Dr. Andres Cardenas 08:10-08:30 hrs. Research in Hepatology- what is hot and what is not! Dr. Marcelo Silva (Argentina) 08:30 08:50 hrs. Liver disease research in children Dr. Ron Sokol (USA) 08:50-09:10 hrs. Principles of Clinical Trials Dr. Anna Lok (USA) 09:10-09:30 hrs. Cohort and case control studies Dr. Ray Kim (USA) 09:30 9:50 hrs. How to set up study databases Dr. Michael Fried (USA) 09:50-10:10 hrs. Q&A 10:10-10:30 hrs. COFFEE BREAK 10:30 10:50 hrs. Ethical and regulatory aspects in clinical research Dr. Michael Fried (USA) 10:50-11:10 hrs. How to write a paper and get published Dr. Guadalupe Garcia-Tsao (Mexico-USA) 11:10 11:30 hrs. Writing a proposal and grant Dr. Anna Lok (USA) 11:30-11:50 hrs. Presentation Skills Dr. Andres Cardenas (Spain)

9 11:50 12:10 hrs. Research training opportunities in North America Dr. Ron Sokol (USA) 12:10 12:30 hrs. Q&A 12:30 13:00 hrs. Lunch 13:00 pm 15:00 pm Lunch with fellows Interaction of all faculty. Poster presentations with feedback on: Design Writing / Style Presentation skills Content / Science Approx Posters in 1 large room with different stations or alternatively 6-8 fellows oral presentations SIMULTANEOUS SESSIONS IN ROOMS A, B, C & D AUTOINMUNE HEPATITIS MODULE (Room A) 15:00 15:20 hrs. Current treatment of autoimmune hepatitis Dr. Alejandra Villamil (Argentina) 15:20 15:40 hrs. Primary Billiary Cholangitis. Therapeutic advances Dr. Tom Hemming Karlsen (Norway) 15:40 16:00 hrs. Pruritus treatment Dr. Richard Sterling (USA) 16:00 16:20 hrs. Overlap syndrome Dr. Tom Hemming Karlsen (Norway) 16:20 16:40 hrs. Case presentation Dr. Enrique Adames (Panama) 16:40 17:00 hrs. Questions & Answers 17:00 17:30 hrs. COFFEE BREAK 17:30 18:30 hrs. INDUSTRY SIMPOSSIUM A-B-C LIVER INFILTRATIVE DISEASES MODULE (Room B) 15:00 15:20 hrs. Wilson s disease: treatment and prognosis Dr. Francisco Hevia (Costa Rica) 15:20 15:40 hrs. Liver disease due to iron deposition Dr. Javier Brahm (Chile)

10 ROUND TABLE DILI 15:20 15:40 hrs. Liver disease due to iron deposition Dr. Javier Brahm (Chile) 15:40 15:55 hrs. How to diagnose DILI? Present and future Dr. Raul J. Andrade (Spain) 15:55 16:15 hrs. What have we learned during the last decade? New drugs & old myths Dr. Raymundo Parana (Brazil) 16:15 16:30 hrs. Accomplishments and progress with the Latin American registry Dr. Nelia Hernandez (Uruguay) 16:30 16:50 hrs. Presentation of 2018 Latin American Guidelines of hepatotoxicity Dr. Fernando Bessone (Argentina) 16:50 17:00 hrs. Questions & Answers 17:00 17:30 hrs. COFFEE BREAK 17:30 18:30 INDUSTRY SIMPOSSIUM LIVER TRANSPLANT MODULE (Room C) 15:00 15:20 hrs. New options for immunosuppression in the transplanted patient Dr. James Trotter (USA) 15:20-15:40 hrs. Indications and evaluation of candidates for liver transplants Dr. George Therapondos (Ochsner Clinic, USA) 15:40 16:00 hrs. Liver transplantation in acute liver failure Dr. Humberto Bohorquez (Ochsner Clinic, USA) 16:00-16:20 hrs. How to grow the donor pool: Asystole, Split, Living Donor Dr. James Trotter (USA) 16:20-16:40 hrs. Case presentation Dr. Juan Suarez (Ecuador) 16:40-17:00 hrs. Questions & Answers session 17:00 17:30 hrs. COFFEE BREAK 17:30 18:30 hrs. INDUSTRY SIMPOSSIUM

11 ALCOHOLIC HEPATITIS AASLD-ALEH (Room D) 15:00 15:20 hrs. What do we know of alcoholic liver disease in Latin America? Dr. Juan Pablo Roblero (Chile) 15:20 15:40 hrs. Treatment of severe alcoholic hepatitis Dr. Ramon Bataller (USA) 15:40 16:00 hrs. Liver transplant in alcoholic liver disease Dr. Michael Curry (USA) 16:00 16:20 hrs. ASH vs non-alcoholic steatohepatitis or both Dr. Arun Sanyal (USA) 16:20 16:40 hrs. Case presentation Dr. Juan Carlos Restrepo (Colombia) 16:40 17:00 hrs. Questions & Answers 17:00 17:30 hrs. COFFEE BREAK 18:30 18:45 hrs. ALEH HEPATOLOGIST LIFETIME ACHIEVEMENT AWARD 18:45 19:00 hrs. ALEH PRESIDENCY HANDOVER CEREMONY 20:30 hrs. CLOSING DINNER SUNDAY, SEPTEMBER 23 RD 08:00-09:00 hrs. INDUSTRY SIMPOSIUM PLENARY SESSION (ROOMS A & B) HEPATOCELLULAR CARCINOMA AND FATTY LIVER DISEASE MODULE HEPATOCELULLAR CARCINOMA 09:00-09:20 hrs. Radiologic diagnosis of hepatocellular carcinoma Dr. Louis Mauricio Morel (Dominican Republic) 09:20-09:40 hrs. Diagnosis and treatment of early stage hepatocellular carcinoma Dr. Christie Perello (Dominican Republic) 09:40-10:00 hrs. Diagnostic and treatment of intermediate-advanced hepatocellular carcinoma Dr. Flair Carihlo (Brazil) 10:00-10:20 hrs. Cholangiocarcinoma Dr. Andres Gelrud (Venezuela).

12 10:20-10:40 hrs. Case presentation Dr. Federico Pineiro (Argentina) 10:40-10:50 hrs. Questions & Answers 10:50-11:10 hrs. COFFEE BREAK FATTY LIVER DISEASE 11:10-11:30 hrs. Epidemiology and natural history of fatty liver disease Dr. Ignacio Aiza (Mexico) 11:30-11:50 hrs. NASH pathogenesis Dr. Milagros Davalos (Peru) 11:50-12:10 hrs. Diagnostic methods in fatty liver disease Dr. Marco Arrese (Chile) 12:10-12:30 hrs. Lifestyle interventions in NASH patients Dr. David Bernstein (USA) 12:30-12:50 hrs. New therapeutic targets Dr. Arun Sanyal (USA) 12:50-13:00 hrs. Questions & Answers 13:00-13:15 hrs. ORAL COMMUNICATION AWARDS CLOSURE

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