CURRICULUM VITAE present: Associate Professor, Pharmaceutical Sciences School of Pharmacy, Palm Beach Atlantic University

Transcription

1 CURRICULUM VITAE EDWIN SANTINI RIOS, PH.D. Palm Beach Atlantic University Lloyd L. Gregory School of Pharmacy West Palm Beach, FL Tel: (787) EDUCATION AND WORK EXPERIENCE 2014-present: Associate Professor, Pharmaceutical Sciences School of Pharmacy, Palm Beach Atlantic University : Assistant Professor, Department of Pharmaceutical Sciences College of Pharmacy, PR Site, Nova Southeastern University : Post-doctoral Fellow, Dept. Pharmacology, Ponce School of Medicine, Ponce, P.R. Research Topic: Application of patch-clamp recording to fear extinction circuits. Mentor: J.T. Porter : Ph.D. in Biomedical Sciences (Neuroscience), Dept. Physiology, Ponce School of Medicine, Ponce, P.R. Thesis topic: Prefrontal NMDA receptors in extinction of fear. Mentor: G.J. Quirk : B.S. (Major-Biology), Interamerican University of Puerto Rico, Ponce P.R. TEACHING EXPERIENCE 2014-present: Neurologic and Psychiatric Pharmacotherapy. Lloyd L. Gregory School of Pharmacy, PBA present: Gastrointestinal, Hepatic, and Renal Pharmacotherapy. Lloyd L. Gregory School of Pharmacy, PBA present: Infectious Disease. Lloyd L. Gregory School of Pharmacy, PBA.

2 : Applied Pharmacology, Graduate Course. Topic: Drug Treatment of Neurodegenerative Disorders. Nova Southeastern University : Molecular and Cellular Pharmacodynamics, Graduate Course. Topics: Ligand-gated Ion Channels, Voltage-gated Ion Channels. Nova Southeastern University : Principles of Neuropharmacology, Pharm.D. Elective Course. Course Coordinator and Lecturer. Nova Southeastern University : Medical Neuroscience Course, MD Students. Invited lecturer at the Ponce School of Medicine, Ponce PR. 2010: Pharmacodynamics III Course. Nova Southeastern University : Research Elective Course. Rotation for Pharm.D. students at the Neuroscience Laboratory. Ponce School of Medicine/Nova Southeastern University, Ponce Site : Advance CNS, Pharm.D. Elective Course. Lecturer and Facilitator at the PR Site, Nova Southeastern University : Clinical Pharmacology Course. Topics: Antidepressants, Antipsychotics and Sedatives/Hypnotics. International and Graduate Programs, Nova Southeastern University : Physiology Course for MD Students. Neurophysiology Lectures. Physiology Department, Ponce School of Medicine, Ponce, P.R. 2006: Human Anatomy and Physiology Laboratory. Biology Department, University of Puerto Rico, Ponce, P.R : Medical Neuroscience Course. T.A. Ponce School of Medicine, Ponce, P.R : Neuroanatomy Laboratory. T.A. Clinical Psychology (Psy.D.) Department, Ponce School of Medicine, Ponce, P.R.

3 HONORS 2006: Travel Award to the American College of the Neuropsychopharmacology (ACNP) Annual Meeting. Hollywood, FL. 2002: Travel Award to the Wisconsin Symposium on Health and Emotion 1999: Travel Award to SACNAS National Conference, Portland, Oregon 1997: Interamerican University Science and Technology Department Award 1997: Magna Cum Laude, Interamerican University of Puerto Rico : University Dean s List RESEARCH FUNDING Submitted: Project Title: Sex-specific effects of morphine withdrawal on anxiety and fear behaviors. National Institute of Health Competitive Research (SCORE) Program SC3 (GM ) Grant application submitted to the National Institute of General Medicine on October Dr. Torres-Reveron (PI), Dr. Santini (Collaborator) : NSU College of Pharmacy Health Professions Division Grant (#335698) awarded to Dr. Edwin Santini (PI). Project Title: The effects of opioid modulation on fear conditioning and extinction in male and female rats : NSU College of Pharmacy Health Professions Division Grant (#335784) awarded to Dr. Edwin Santini (PI), Dr. Torres-Reveron (Co-PI) and Dr. Ramos Ortolaza (Collaborator). Project Title: The effects of chronic morphine treatment in fear conditioning in male and female rats at different stages of the estrous cycle : Chancellor s Faculty Research and Development Grant (#335841) awarded to Dr. Edwin Santini (PI), Dr. Ramos Ortolaza (Co-PI) and Dr. Torres-Reveron (Collaborator). Project Title: Acute morphine after fear learning: implications for sex-specific PTSD treatment.

4 : National Science Foundation Grant (IOS ) awarded to Dr. James T. Porter (Co-PI), Dr. Gregory J. Quirk (Co-PI) and Dr. Edwin Santini (Collaborator). Project Title: Applying in vitro recording techniques to extinction of conditioned fear : Fellow of the National Research Service Award (NRSA) from the National Institute of Mental Health (F-31 MH066575) Project Title: The role of NMDA receptors and protein synthesis in fear extinction. ORGANIZATIONS Society for Neuroscience (SfN) Molecular and Cellular Cognition Society COMMITTEES 2015-present: Student Recruitment and Admissions Committee (PBA) 2015-present: Promotions Committee (PBA) 2014-present: Research Resource Committee (PBA) 2014-present: Evaluation and Assessment Committee (PBA) : Curriculum Committee (NSU) : Appeals Committee (NSU) 2013: Search Committee for the Assistant Dean, Puerto Rico Site (NSU) : Admissions Committee (NSU) 2012: Technology Task Force Committee (NSU) 2011: Search Committee for the Chair of the Pharm. Science Dept (NSU) 2010: Faculty Research Committee (NSU) : Departmental Recruitment Committee (NSU)

5 PEER-REVIWED PUBLICATIONS Perez-Torres E, Ramos-Ortolaza D, Morales R, Santini E, Rios-Ruiz E & Torres- Reveron A (2015) Morphine administration during low ovarian hormone stage results in transient over expression of fear memories in females. Front Behav Neurosci. 9: 129 Criado-Marrero M, Santini E & Porter JT (2014) Modulating fear extinction by manipulating SK potassium channels in the infralimbic cortex. Front Behav Neurosci. 8: 96 Santini E, Sepulveda M & Porter JT (2012) Muscarinic receptors modulate the intrinsic excitability of infralimbic neurons and fear extinction. Neuropsychopharmacology. 37(9): Santini E & Porter JT (2010) M-type potassium channels modulate the intrinsic excitability of infralimbic neurons and regulate fear expression and extinction. J Neurosci. 15;30(37): Fontanez-Nuin DE, Santini E, Quirk GJ & Porter JT (2010) Memory for Fear Extinction Requires mglur5-mediated Activation of Infralimbic Neurons. Cereb Cortex. 21(3): Santini E, Quirk GJ and Porter J (2008) Fear conditioning and extinction differentially modify the intrinsic excitability of infralimbic neurons. J Neurosci 28: Burgos-Robles A, Vidal-González I, Santini E and Quirk GJ. (2007) Blockade of NMDA receptors in the ventromedial prefrontal cortex impairs consolidation of extinction and reduces burst firing. Neuron 53: Quirk GJ, Milad MR, Santini E, Lebron K (2007) Learning not to fear: A neural systems approach. In Kirmayer L, Lemelson R & Barad M (Eds.), Understanding Trauma: Integrating Cultural, Psychological and Biological Perspectives (60-77). New York, USA. Cambridge University Press, New York. Santini E, Ge H, Ren K, Peña de Ortiz S and Quirk GJ (2004) Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex. J Neurosci 24:

6 Santini E, Muller RU, Quirk GJ (2001) Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependant memory. J Neurosci 21: PRESENTATIONS E.M. Perez-Torres, R. Morales Silva, D.L. Ramos-Ortolaza, E. Santini & A. Torres-Reverón (2014) Specific Expression of Mu Opioid Receptors in Brain Structures involved in Fear Conditioning and Extinction Learning. Puerto Rico Neuroscience: 23rd Annual Conference. E.M. Perez-Torres, R. Morales Silva, D.L. Ramos-Ortolaza, E. Santini & A. Torres-Reverón (2014) The Role of Mu Opioid Receptors in Fear Conditioning and Extinction. National Institute on Minority Health and Health Disparities (NIMHD) Conference Martinez-Casiano K, Ramos-Ortolaza D, Perez-Torres E, Alonso Y, Santini E, Torres-Reverón A (2013) Female ovariectomized rats are protected from the effects of chronic morphine treatment on fear conditioning and extinction. Society for Neuroscience, San Diego, CA. Perez-Torres E, Ramos-Ortolaza D, Martinez-Casiano K, Alonso Y, Toro- Bahamonde A, Santini E, Torres-Reverón A (2013) Acute morphine or naloxone after fear learning: implications for sex-specific PTSD treatment. Society for Neuroscience, San Diego, CA. Morales-Silva R, Perez-Torres E, Santini E, Ramos-Ortolaza D, Torres-Reverón A (2013) Opioid agonist and antagonist effect after fear conditioning on the expression of mu opioid receptors from female rat brains. Annual Biomedical Research Conference for Minority Students (ABRCMS), Nashville, TN. Pérez-Torres E, Ramos-Ortolaza D, Alvarado J, Santini E, Torres-Reverón A (2012) Acute morphine after fear learning: implications for sex-specific PTSD treatment. Society for Neuroscience, New Orleans, LA. Ramos-Ortolaza D, Pérez-Torres E, Alvarado J, Torres-Reverón A, Santini E (2012) Females are protected from the effects of chronic morphine, while males showed impairment in fear extinction and recall. Society for Neuroscience, New Orleans, LA.

7 Pérez-Torres E, Ramos-Ortolaza D, Alvarado J, Santini E, Torres-Reverón A (2012) Acute morphine after fear learning: implications for sex-specific PTSD treatment. Research Centers in Minority Institutions (RCMI), San Juan, PR. Santini E, Sepulveda M & Porter JT (2011) The role of muscarinic receptors in prefrontal excitability and fear extinction. Experimental Biology Meeting, San Diego, Ca. Santini E, Fontanez-Nuin D and Porter J (2009) Muscarinic receptors regulate infralimbic excitability and fear extinction. Society for Neuroscience, Chicago,IL. Fontanez-Nuin D, Santini E, Quirk GJ & Porter JT (2009) Activation of Metabotropic Glutamate Receptors Subtype 5 (mglur 5) modulates both the intrinsic excitability of medial prefrontal cortex neurons and recall of extinction. Society for Neuroscience, Chicago, IL. Santini E, Nigaglioni J and Porter J (2009) Blockade of SK channels enhances infralimbic excitability and facilitates recall of fear extinction. Society for Neuroscience, Chicago, IL. Santini E, Quirk GJ and Porter J (2008) Blockade of M-type potassium channels enhances the intrinsic excitability of infralimbic neurons, reduces fear expression and facilitates extinction learning. Society for Neuroscience, Washington, DC. Fontánez-Nuin DE, Santini E, Quirk GJ and Porter J (2008) Consolidation of fear extinction requires activation of metabotropic glutamate receptor subtype 5 (mglur5) in infralimbic cortex. Society for Neuroscience, Washington, DC. Santini E, Quirk GJ and Porter J (2006) Extinction reverses the conditioninginduced depression of infralimbic neuronal excitability. Society for Neuroscience, Atlanta, GA. Santini E, Quirk GJ and Porter J (2005) The effect of fear extinction in the intrinsic excitability of pyramidal cells in the ventro-medial prefrontal cortex. Society for Neuroscience, Washington, DC.

8 Vazquez A, Santini E, Ren K, Sepulveda M, Ortiz-Zuazaga HG, Quirk GJ and Peña de Ortiz S (2004) Gene expression profiling in the rat medial prefrontal cortex: Defining the genomic blueprint for long-term memory of extinction of conditioned tone fear. 13 th Annual Puerto Rico Neuroscience Conference, San Juan, P.R. Burgos-Robles A, Santini E and Quirk GJ (2004) Blockade of NMDA receptors in the medial prefrontal cortex impair consolidation of fear extinction. Society for Neuroscience, San Diego, CA. Santini E, Ren K, Ge H, Peña de Ortiz S and Quirk GJ (2003) Consolidation of fear extinction involves protein synthesis and gene expression in the medial prefrontal cortex. The American College of Neuropsychopharmacology (ACNP) Annual Meeting, San Juan, P.R. Santini E, Burgos A and Quirk GJ (2003) Protein synthesis in the medial prefrontal cortex (mpfc) is required for consolidation of extinction memory. Society for Neuroscience, New Orleans, USA. Santini E and Quirk GJ (2003) Long-term memory for extinction of auditory fear conditioning requires protein synthesis. International Behavioral Neuroscience Society (IBNS), San Juan, P.R. Santini E and Quirk GJ (2002) Long-term memory for extinction of auditory fear conditioning requires protein synthesis. Society for Neuroscience, Orlando, FL. Quirk GJ, Rosaly E, Romero RV, Santini E and Muller RU (1999) NMDA receptors are required for long-term but not short-term memory of extinction learning. Society for Neuroscience, Miami, FL. THESIS ADVISOR Emily Perez, Ph.D Candidate in Psychology Proposal Title: Sex-specific role of opioid system on fear conditioning and extinction: implications for PTSD treatment. Expected graduation date: May 2014

9 Karla Martinez-Casiano, Ph.D Candidate in Psychology Proposal Title: Sex differences in spontaneous withdrawal from chronic morphine in anxiety and associative emotional learning: implications for addiction treatment. Expected graduation date: May 2015 REFERENCES AVAILABLE UPON REQUEST