-1- Pathology Department (code: 0605) Final Exam for Third year students Date: Time allowed: 2 hours. Paper II (75 marks).

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1 -1- BENHA UNIVERSITY FACULTY OF MEDICINE Pathology Department (code: 0605) Final Exam for Third year students Date: Time allowed: 2 hours. Paper II (75 marks). Please note that this question papers consists of 10 pages including the front page. It is the student responsibility to count and check the paper. All Questions should be answered. Please write your answer below each question. QUESTION NUMBER MARK FIRST SIGNATURE SECOND SIGNATURE الدرجة بالحروف: Student Name: 28/5/2011. Pathology Department Student Number: Code number

2 -2- Question I: Define the following: (each 1 mark) 1- Cervical Intraepithelial Neoplasia. 2- Locally malignant tumors. 3- Apoptosis. 4- Chemotaxis. 5- Granuloma. 6- Hydrocephalus. 7- Heamochromatosis. 8- Barrett s oesophagus. 9- Endometriosis. 10- Paget's disease of The Nipple.

3 -3- Question Number 2. Explain the pathogenesis of: 1- Abscess. (each 2 ½ marks) 2- Peptic ulcer. 3- Cirrhosis. 4- Adenoma-carcinoma sequence of colon.

4 -4- Question Number 3: 1- List 5 Differences Between Ulcerative Colitis and Crohn's Disease. (5 marks) Ulcerative colitis Crohn's Disease

5 -5- Question Number 3: 2- List differences between primary and secondary amyloidosis. (5 marks) Primary amyloidosis Secondary amyloidosis. Type of amyloid Etiology Pathogenesis.

6 -6- Question Number 4: Describe in short: 1- Morphologic changes in chronic cervicitis. (each 3 marks) 2- Morphology of vesicular mole. 3- Microscopic Picture of Intraductal Carcinoma- Breast. 4- Microscopic picture of Adenoma of the colon. 5- Microscopic picture of fibrocystic disease of the breast.

7 -7- Question Number 5. Enumerate: 1- Histopathologic types of Hodgkin's Lymphoma. (each 2 marks) 2- Morphological types of endometrial hyperplasia. 3- Histologic Types of Malignant Thyroid Tumors. 4- Types of Gall Bladder stones.. 5- Types of ovarian cysts.

8 -8- Question Number 6: (each 5 marks) I- Case No. 1 A 24 years old female complained of lower abdominal fullness and heaviness. By clinical examination a large Left pelvic swelling was detected. Radiological examination reveals a rounded ovarian cystic swelling with a radio opaque shadow looks-like a tooth. 1- The probable diagnosis is: 2- Types of this tumor are: 3- Microscopic picture of this lesion is: II- Case No. 2 A 65 years old male complaining of bleeding per rectum since 3 months. Colonoscopic examination revealed an ulcer having necrotic floor and raised everted edges. 1- the most Probable diagnosis is: 2- Enumerate Different Gross Pictures of this lesion: a- b- c- 3- Different Microscopic pictures of these lesions are:

9 -9- Question No. 7. (each 1/2 mark) A- Choose the most appropriate answer: 1- Concerning Barrett's esophagus all the following are true EXCEPT: a. Usually found in the lower esophagus. b. It is irreversible lesion. c. It is a premalignant lesion. d. Reflux esophagitis may be a cause. 2- Concerning Membranous inflammation all the following are true EXCEPT: a. Complicated by Toxemia. b. Complicated by septicemia. c. Non-suppurative inflammation. d. The causative organism is localized in the mucosa. 3- Leukoplakia: a. Is a precancerous lesion b. Is due to chronic irritation c. Is whitish thick patches with sharp outlines d. Is characterized by stratified squamous epithelium hyperplasia and submucosal chronic inflammation and fibrosis e. All of the above 4- Helicobacter Pylori, which of the following is NOT correct: a. Associated with gastric carcinoma and lymphoma b. Causes a chronic lymphoid infiltration c. Causes a chronic gastritis by invading the mucosa. d. None of the above. 5- In amoebic dysentery, ulcer is: b. Flask-shaped b. With indurated base c. Usually in transverse colon d. None of the above 6- Nodular goiter is characterized by the following features EXCEPT: a. Iodine deficiency plays role in the etiology b. There repeated hyperplasia and involution c. The re is deficient thyroid hormone production d. There is decreased TSH stimulation 7- Cervical Intraepithelial Neoplasia: a. Is an invasive malignant tumor b. Is an inflammatory condition c. Is associated with delayed marriage d. None of the above e. All of the above 8- Leiomyoma, which of the following is NOT true: a. Often results in uterine bleeding b. Has a high mitotic rate c. Is commonly multiple d. Responds to changes in female hormone levels 9- Fibrocystic change of the breast: a. Is the most common problem of the female breast b. Is characterized by fibrosis c. Is characterized by cyst formation d. Is characterized by apocrine metaplasia e. All of the above. 10- Phyllodes tumors: a. Occur in a younger age group than fibroadenomas. b. Present as a discrete lump larger than fibroadenoma.

10 -11- c. Are distinguished from fibroadenomas by a less cellular stroma. d. Metastasize predominantly by the lymphatic route. B- Mark T for true statement and F for false one: T F 1- Fibrocystic disease shows unilateral, capsulated, firm mass. 2- Invasive ductal carcinoma is more frequently bilateral than invasive lobular carcinoma. 3- Intraduct papilloma may turn malignant. 4- Adenomyosis is presence of nests of endometrial tissue outside the uterine cavity. 5- Endometrial hyperplasia is one of the common causes of abnormal uterine bleeding in the Perimenopause period. 6- Tumors arising from surface epithelium of the ovaries are always unilateral 7- Appendicular carcinoid tumor is a locally malignant tumor (or of erratic behaviour. 8- Pyemia is due to impaction of aspetic emboli in smaller blood vesselsof different organs. 9- In repair by regeneration, there is replacement of the damaged tissue by granulation tissue which matures to fibrous tissue. 10- Metastatic calcification predisposes to the formation of renal calculi. Good Luck

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