Chapter 6. Hormonal Control of Calcium Homeostasis. Nam Deuk Kim, Ph.D.
|
|
- Amie Golden
- 5 years ago
- Views:
Transcription
1 Chapter 6 Hormonal Control of Calcium Homeostasis Nam Deuk Kim, Ph.D. 1
2 1. Calcium and Bone Physiology Plasma Ca 2+ must be closely regulated to prevent changes in neuromuscular excitability Also plays vital role in a number of essential activities Neuromuscular excitability Stimulus-secretion coupling Excitation-contraction coupling in cardiac and smooth muscle Maintenance of tight junctions between cells Clotting of blood Hypercalcemia Reduces excitability Hypocalcemia Brings about overexcitability of nerves and muscles Severe overexcitability can cause fatal spastic contractions of respiratory muscles 2
3 Endocrine Control of Calcium Metabolism Three hormones regulate plasma concentration of Ca 2+ (and PO 4 3- ) Parathyroid hormone (Parathormone, PTH) Calcitonin Vitamin D 3
4 Ca ++ : PTH V-D3 Ca ++ : Calcitonin Hydroxyapatite: Ca 10 (PO 4 ) 6 (OH) 2 4
5 Bone continuously undergoes remodeling. 5
6 Osteocyte Central canal Lamella Canaliculi Osteon Blood vessel from marrow Central canal Vessel in central canal 6
7 7
8 Role of osteoblasts in governing osteoclast development and activity 8
9 Relationship of mineralized bone, bone cells, bone fluid, and the plasma Osteoblast Osteocyte Osteocytic osteoblastic bone membrane Osteoblast Outer surface Mineralized bone Blood vessel Canaliculi Bone fluid Central canal Lamellae 9
10 Relationship of mineralized bone, bone cells, bone fluid, and the plasma In canaliculi In central canal Mineralized bone: stable pool of Ca 2+ Bone fluid: labile pool of Ca 2+ Plasma Fast exchange Slow exchange (Bone dissolution) = Membrane-bound Ca 2 + pump 10
11 Endocrine Control of Calcium Metabolism Parathyroid hormone (PTH) Secreted by parathyroid glands Primary regulator of Ca 2+ Raises free plasma Ca 2+ levels by its effects on bone kidneys, and intestines Essential for life Prevents fatal consequences of hypocalcemia Facilitates activation of Vitamin D 11
12 Fig. 9-1: Posterior (left) and transverse (right) views of the human thyroid with attached parathyroids. 12
13 2. Parathormone Chief Cells : ( 주세포 ) Parathyroid Hormones (Parathormone, PTH) 혈중칼슘농도증가유지 13
14 Fig. 9-2: Comparative structures of parathormone (PTH). 14
15 Synthesis, chemistry, and metabolism of PTH - A polypeptide 84 aa long, derived from a precursor molecule of 115 aa. - Preproparathyroid hormone (115 aa prepropth) 90 aa propth 84 aa PTH Control of PTH secretion - Release of PTH from the gland is controlled by circulating levels of Ca 2+ - Ca 2+ -sensing receptor [calcium-sensing receptor (CaSR)] : a typical seven-spanning membrane G- protein coupled receptor - Human Ca 2+ -sensing receptor: 1,018 aa with 93% sequence similarity to the bovine receptor 15
16 Parathyroid Chief Cells Pre Pro PTH Rough Endoplasmic Reticulum consitutive synthesis PreproPTH Cisternal space of RER signal peptidase action ProPTH Golgi Apparatus processing Granules packaging PTH Low Ca 2+ Secretion Prepro-PTH and its processing to secreted PTH in the parathyroid chief cells. Negative numbers indicate the number of amino acids prior to the first amino acid in PTH 16
17 PTH acts to raise plasma Ca 2+ levels - Bone mineral metabolism - Renal reabsorption of calcium - Renal excretion of phosphate - Intestinal absorption of calcium - Control of vitamin D synthesis - Other possible actions of PTH: increases the mitotic rate of red cell progenitors (reticulocytes) and thymic lymphocytes. 17
18 Interaction between PTH and V-D in controlling plasma calcium 18
19 3. Parathormone-related Peptide (PTHrP) PTHrP: isolated from human tumor cells or tissues obtained from patients with humoral hypercalcemia of malignancy PTHrP: aa resides, depending upon the species. Fig. 9-3: Aligned sequences of the 1 34 region of PTH and PTHrP from various species. Conserved residues are outlined in black. Note the lack of substantial sequence identity between PTH and PTHrP from amino acid residue 14 through the C terminus. 19
20 Calcitonin 4. Calcitonin Hormone produced by C cells of thyroid gland Negative-feedback fashion Secreted in response to increase in plasma Ca 2+ concentration Acts to lower plasma Ca 2+ levels by inhibiting activity of bone osteoclasts Unimportant except during hypercalcemia Fig. 9-4: Primary structure of human calcitonin. 20
21 C cell (Calcitonin) 21
22 Fig. 9-5: Comparative structures of some calcitonins. Three molecular species (isoforms) of salmon CT exist; the structure of salmon I calcitonin is shown, which differs from eel CT at only three residues (eel: 26, Asp; 27, Val; 29, Ala). 22
23 Calcitonin acts to lower plasma Ca 2+ levels - Bone mineral metabolism: - Calcitonin as a satiety hormone: Subcutaneous (s.c.) injections of CT inhibit the 24-hour food intake of rats and rhesus monkeys. Intracerebroventricular injections of CT in the rat are also inhibitory to feeding. In humans, significant reduction in body weight is observed 24 to 36 hours following a single s.c. injection of CT. - Vitamin D regulation: CT directly stimulates V-D metabolism and indirectly stimulates it by lowering plasma Ca 2+ levels, resulting in the release of PTH, which activates renal vitamin D synthesis and secretion. 23
24 Negative-feedback Loops Controlling Parathyroid Hormone (PTH) and Calcitonin Secretion 24
25 25
26 26
27 5. Vitamin D Stimulates Ca 2+ and PO 4 3- absorption from intestine Can be synthesized from cholesterol derivative when exposed to sunlight Often inadequate source Amount supplemented by dietary intake Must be activated first by liver and then by kidneys before it can exert its effect on intestines 27
28 Precursor in skin (7-dehydrocholesterol) Sunlight Dietary vitamin D Vitamin D 3 Hydroxyl group (OH) Liver enzymes 25-OH D 3 Hydroxyl group PTH Plasma Ca 2+ Kidney enzymes + Activation of Vitamin D 1, 25-(OH) 2 D 3 (active vitamin D) Plasma PO4 3- Promotes intestinal absorption of Ca 2+ and PO
29 Fig. 9-6: Photic stimulation of integumental cholecalciferol (vitamin D 3 ) formation and subsequent transfer to the general circulation by a cholecalciferol-binding protein. 29
30 Fig. 9-7: Production of ergosterol and ergocalciferol from their precursors. 30
31 Fig. 9-8: Sequential steps in the biosynthesis of vitamin D. 31
32 Fig. 9-9: Feedback control of vitamin D biosynthesis. 32
33 V-D promotes Ca 2+ absorption in the gut and Ca 2+ reabsorption in the kidney. - Intestine: - Bone: - Kidney: - Other putative roles: 33
34 Interaction between PTH and V-D in controlling plasma calcium 34
35 Control of plasma phosphate 35
36 36
37 1) PTH 6. Hormone Mechanisms of Action in Calcium Homeostasis Fig. 9-10: Cell-surface receptors for PTH are coupled to two classes of G proteins. G s mediates stimulation of adenylyl cyclase (AC) and the production of camp, which in turn activates protein kinase A (PKA). G q stimulates phospholipase C (PLC) to form the second messengers inositol-(1,4,5)-triphosphate (IP 3 ) and diacylglycerol (DAG) from membranebound phosphatidyl-inositol-(4,5)-biphosphate. IP 3 increases intracellular calcium (Ca 2+ ) and DAG stimulates protein kinase C (PKC) activity. Each G protein consists of a unique chain and dimer. 37
38 Regulation of PTH secretion Secretion of parathyroid hormone is controlled chiefly by serum [Ca 2+ ] through negative feedback. Calcium-sensing receptors located on parathyroid cells are activated when [Ca 2+ ] is low. The G-protein coupled calcium receptors (CaR) sense extracellular calcium and may be found on the surface on a wide variety cells distributed in the brain, heart, skin, stomach, C cells, and other tissues. In the parathyroid gland, sensation of high concentrations of extracellular calcium result in activation of the Gq G- protein coupled cascade through the action of phospholipase C. This hydrolyzes phosphatidylinositol 4,5- bisphosphate (PIP2) to liberate intracellular messengers IP 3 and diacylglycerol (DAG). Ultimately, these two messengers result in a release of calcium from intracellular stores and a subsequent flux of extracellular calcium into the cytoplasmic space. The effect of this signaling of high extracellular calcium results in an intracellular calcium concentration that inhibits the secretion of preformed PTH from storage granules in the parathyroid gland. In contrast to the mechanism that most secretory cells use, calcium inhibits vesicle fusion and release of PTH. 38
39 Stimulators of PTH secretion - Decreased serum [Ca 2+ ]. - Mild decreases in serum [Mg 2+ ]. - An increase in serum phosphate (increased phosphate causes it to complex with serum calcium, forming calcium phosphate, which reduces stimulation of Ca-sensitive receptors (CaSr) that do not sense calcium phosphate, triggering an increase in PTH) Inhibitors of PTH secretion - Increased serum [Ca 2+ ]. - Severe decreases in serum [Mg 2+ ], which also produces symptoms of hypoparathyroidism (such as hypocalcemia). - Hypermagnesemia - Calcitriol In the parathyroids, magnesium serves this role in stimulussecretion coupling. Magnesium: a natural calcium antagonist Hypomagnesia inhibits PTH secretion and also causes resistance to PTH, leading to a form of hypoparathyroidism that is reversible. Hypermagnesemia also results in inhibition of PTH secretion when a moderate low calcium concentration is present. 39
40 Magnesium and the parathyroid Curr Opin Nephrol Hypertens. (2002) 11(4): The serum levels of parathyroid hormone and magnesium depend on each other in a complex manner. The secretion of parathyroid hormone by the parathyroid is physiologically controlled by the serum calcium level, but magnesium can exert similar effects. While low levels of magnesium (mild decrease) stimulate parathyroid hormone secretion, very low serum concentrations (hypomagnesemia) induce a paradoxical block. This block leads to clinically relevant hypocalcemia in severely hypomagnesiemic patients. The mechanism of this effect has recently been traced to an activation of the alphasubunits of heterotrimeric G-proteins. Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration Nephrol Dial Transplant (2014) 29: Results: I. Increasing Mg concentrations from 0.5 to 2 mm produced a left shift of PTH Ca curves. II. With Mg 5 mm, the secretory response was practically abolished. Mg was able to reduce PTH only if parathyroid glands were exposed to moderately low Ca concentrations; with normal high Ca concentrations, the effect of Mg on PTH inhibition was minor or absent. Conclusions. Mg reduces PTH secretion mainly when a moderate low calcium concentration is present; Mg also modulates parathyroid glands function through upregulation of the key cellular receptors CaR, VDR and FGF23/Klotho 40 system.
41 2) Calcitonin (CT): Receptors for CT are present in skeletal tissue, kidney, and testicular Leydig cells. Osteoblast Bone constructor Osteoclast Bone destructor PTH G s camp PKA IL-6; other cytokines ODF IL-6 activation inactivation PKA camp G s CT Calcitonin (CT) secreted by thyroid C-cells in response to hypercalcemia. CT gene can yield calcitonin gene-related peptide (CGRP) if processed differently (alternative mrna splicing). CGRP = a potent vasodilator Control of bone remodeling by PTH and calcitonin 41
42 Receptor for calcitonin The calcitonin receptor, found on osteoclasts, and in kidney and regions of the brain. G protein-coupled receptor, which is coupled by G s to adenylate cyclase and thereby to the generation of camp in target cells. It may also affect the ovaries in women and the testes in men. Uses of calcitonin Calcitonin can be used therapeutically for the treatment of hypercalcemia or osteoporosis. Oral calcitonin may have a chondroprotective role in osteoarthritis (OA) How calcitonin affects osteoarthritis (OA)? Calcitonin acts both directly on osteoclasts, resulting in inhibition of bone resorption and following attenuation of subchondral bone turnover, and directly on chondrocytes, attenuating cartilage degradation and stimulating cartilage formation 42
43 3) Vitamin D Fig. 9-11: Mechanism of action and general functions of 1,25(OH) 2 D 3 in target cells. 43
44 7. Hormone Integration in Calcium Homeostasis Fig. 9-12: Generalized model of the role of hormones controlling bone mineralization and demineralization. 44
45 8. Hormonal Regulation of Intracellular Calcium Fig. 9-13: Primary structure of calmodulin (CaM), an intracellular calcium receptor. The following are one-letter codes for amino acid residues: A, Ala; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; Y, 45 Tyr.
46 Calcium release in excitation-contraction coupling. 46
47 Fig. 9-14: Model for the mechanism of action of calmodulin. 47
48 9. Pathophysiology 1) Hypoparathyroidism results in hypocalcemia. 2) Hyperparathyroidism results in hypercalcemia. 3) Hypercalcemia can accompany some malignancies. 4) Osteomalacia is a condition of inadequate bone mineralization. 5) Paget s disease is characterized by excess osteoclastic activity. 6) Osteoporosis is a condition of decreased bone mineral density. a. Postmenopausal (Type I) osteoporosis b. Senile (Type II) osteoporosis 7) New pharmacological therapies for diseases of Ca 2+ homeostasis are available. a. Bisphosphonates b. Selective estrogen receptor modulators (SERMs) c. Pharmaceutical preparations of vitamin D. d. Dietary calcium and osteoporosis 48
49 Parathyroid Glands Calcium Metabolism Blood calcium is in equilibrium with calcium in the bone Calcium level is regulated by the parathyroid glands Reduced calcium in blood: tetany (increases neuromuscular excitability, causing spasm of skeletal muscle) Elevated calcium in blood: reduces neuromuscular excitability 49
50 Calcium Disorders PTH hypersecretion (hyperparathyroidism) Characterized by hypercalcemia and hypophosphatemia PTH hyposecretion (hypoparathyroidism) Characterized by hypocalcemia and hyperphosphatemia Vitamin D deficiency Children rickets Adults osteomalacia 50
51 Completed Picture of Updated Calcium/Parathyroid Hormone Normogram ( ) 51
52 Hyperparathyroidism Usually a result of hormone-secreting parathyroid adenoma Blood calcium rises Excessive calcium withdrawn from bone Excessive calcium excreted in urine Treated by removal of tumor 52
53 원발성부갑상샘기능항진증 (Primary Hyperparathyroidism) : PTH 과다분비 원인 : 1. 샘종 (80%) 2. 원발성증식증 (10~15%) 3. 샘암종 (5% 이하 ) 53
54 부갑상샘기능항진증조직학적변화 1. Adenoma 2. Primary hyperplasia: Chief cell 3. Primary hyperplasia: Clear cell 4. Secondary hyperplasia 5. Carcinoma 54
55 부갑상샘기능항진증임상증상 1. 혈중 PTH 상승 2. 고칼슘혈증 3. 저인산염혈증 4. 낭종섬유성골염 5. 신장결석 6. 정서적불안 7. 기억력감퇴 8. 근약화 9. 전이성칼슘침착 10. 위장의소화성궤양 55
56 고칼슘증감별진단법 1. Hyperparathyroidism 2. Milk-Alkali syndrome 3. V-D intoxication 4. Sarcoidosis 5. Multiple myeloma 6. Metastatic ca. 7. Primary ca, not involving bone 8. Disuse atrophy (osteoporosis) 9. Thyrotoxicosis 56
57 Hypoparathyroidism Usually result of removal of parathyroid glands during thyroid surgery Blood calcium falls precipitously Leads to neuromuscular excitability and tetany Treated with high-calcium diet and supplementary vitamin D 57
58 부갑상샘기능저하증 (Hypoparathyroidism) : 혈중저칼슘증발생 1. 갑상샘절제술 2. 특발성 3. 가족성 4. 가성 : PTH 에대한무감응 58
59 부갑상샘기능저하증 (Hypoparathyroidism) 임상증상 : 저칼슘혈증 근 - 신경흥분성 Trousseau s sign Chvostek s sign Convulsion Laryngeal spasm Choked disk 정서불안 정신병 59
60 골연화증 / 구루병 골연화증 (Osteomalacia): 새로이형성된뼈기질에미네랄화가부적절한것을특징으로하는성인질환 구루병 (Rickets): 골단이열려있는어린이에서발생하는유사질환 비타민 D 대상의비정상, 인산결핍상태및미네랄화과정자체의결함등 60
61 골연화증 (Osteomalacia) 구루병 (Rickets) 61
62 62
63 Paget's disease of bone Paget's disease of the bone (other terms are Paget's disease, osteitis deformans, osteodystrophia deformans): a chronic disorder that typically results in enlarged and deformed bones. The disease is named after Sir James Paget, the British surgeon who first described it in The excessive breakdown and formation of bone tissue that occurs with Paget's disease can cause bone to weaken, resulting in bone pain, arthritis, deformities, and fractures. Paget's disease is rarely diagnosed in people less than 40 years of age. Women are more commonly affected than men. Prevalence of Paget's disease ranges from 1.5 to 8.0 percent, depending on age and country of residence. Prevalence of familial Paget's disease (where more than one family member has the disease) ranges from 10 to 40 percent in different parts of the world. Because early diagnosis and treatment is important, after age 40, siblings and children of someone with Paget's disease may wish to have an alkaline phosphatase blood test every two or three years. If the alkaline phosphatase level is above normal, other tests such as a bonespecific alkaline phosphatase test, bone scan, or X-ray can be performed. 63
64 뼈의파제트병 Paget Disease of Bone 64
65 65
66 Urinary hydroxyproline elevated 66
67 Osteoporosis Generalized thinning of the bone and dimineralization of the entire skeletal system, porous bones Most common in postmenopausal women Loss of estrogen accelerates rate of bone resorption Also develops in elderly men Remember that osteoporosis is not the same as osteoarthritis Osteoarthritis is the wear and tear degeneration of one or more of the weight-bearing joints 67
68 68
69 69
70 70
71 May 4, 2003 골다공증 It was a dramatic end to a 5 1/2- month space station mission for Ken Bowersox, who served as the commander, astronaut Donald Pettit and cosmonaut Nikolai Budarin. Russian spotters carry astronaut Ken Bowersox at the landing site of the Soyuz space capsule that returned him and two others to Earth. 71
72 72
73 73
Calcium metabolism and the Parathyroid Glands. Calcium, osteoclasts and osteoblasts-essential to understand the function of parathyroid glands
Calcium metabolism and the Parathyroid Glands Calcium, osteoclasts and osteoblasts-essential to understand the function of parathyroid glands Calcium is an essential element for contraction of voluntary/smooth
More informationThe Parathyroid Glands
The Parathyroid Glands Bởi: OpenStaxCollege The parathyroid glands are tiny, round structures usually found embedded in the posterior surface of the thyroid gland ([link]). A thick connective tissue capsule
More informationEndocrine Regulation of Calcium and Phosphate Metabolism
Endocrine Regulation of Calcium and Phosphate Metabolism Huiping Wang ( 王会平 ), PhD Department of Physiology Rm C516, Block C, Research Building, School of Medicine Tel: 88208252 Email: wanghuiping@zju.edu.cn
More informationOMICS Journals are welcoming Submissions
OMICS Journals are welcoming Submissions OMICS International welcomes submissions that are original and technically so as to serve both the developing world and developed countries in the best possible
More informationRahaf AL-Jafari. Marah Qaddourah. Rahmeh Abdullah. Saleem. 1 P a g e
15 Rahaf AL-Jafari Marah Qaddourah Rahmeh Abdullah Saleem 1 P a g e If you are following with the record you may notice a little bit difference in information sequences. Hormones that function on growth
More information17. CALCIUM AND PHOSPHOROUS METABOLISM. Calcium. Role of calcium ROLE OF CALCIUM STORAGE. Calcium movement
17. CALCIUM AND PHOSPHOROUS METABOLISM Many physiological processes are regulated directly or indirectly by calcium. Furthermore, the main physical structure of vertebrates and other species depend on
More information20. CALCIUM AND PHOSPHOROUS METABOLISM
20. CALCIUM AND PHOSPHOROUS METABOLISM Many physiological processes are regulated directly or indirectly by calcium. Furthermore, the main physical structure of vertebrates and other species depend on
More informationCa, Mg metabolism, bone diseases. Tamás Kőszegi Pécs University, Department of Laboratory Medicine Pécs, Hungary
Ca, Mg metabolism, bone diseases Tamás Kőszegi Pécs University, Department of Laboratory Medicine Pécs, Hungary Calcium homeostasis Ca 1000g in adults 99% in bones (extracellular with Mg, P) Plasma/intracellular
More informationFig Articular cartilage. Epiphysis. Red bone marrow Epiphyseal line. Marrow cavity. Yellow bone marrow. Periosteum. Nutrient foramen Diaphysis
Fig. 7.1 Articular cartilage Epiphysis Red bone marrow Epiphyseal line Marrow cavity Yellow bone marrow Nutrient foramen Diaphysis Site of endosteum Compact bone Spongy bone Epiphyseal line Epiphysis Articular
More informationThe Parathyroid Glands Secrete Parathyroid Hormone, which Regulates Calcium, Magnesium, and Phosphate Ion Levels
17.6 The Parathyroid Glands Secrete Parathyroid Hormone, which Regulates Calcium, Magnesium, and Phosphate Ion Levels Partially embedded in the posterior surface of the lateral lobes of the thyroid gland
More informationChapter 17. Lecture and Animation Outline
Chapter 17 Lecture and Animation Outline To run the animations you must be in Slideshow View. Use the buttons on the animation to play, pause, and turn audio/text on or off. Please Note: Once you have
More informationFunctions of the Skeletal System. Chapter 6: Osseous Tissue and Bone Structure. Classification of Bones. Bone Shapes
Chapter 6: Osseous Tissue and Bone Structure Functions of the Skeletal System 1. Support 2. Storage of minerals (calcium) 3. Storage of lipids (yellow marrow) 4. Blood cell production (red marrow) 5. Protection
More informationParathyoid glands and PTH
Parathyoid glands and PTH They are four glands located behind the thyroid gland, each one from (20-50) mg in weight, and composed of two types of cells: 1. Cheif cells: that produces PTH. 2-oxyphil cells:
More informationAgents that Affect Bone & Mineral Homeostasis
Agents that Affect Bone & Mineral Homeostasis 1 Agents that Affect Bone & Mineral Homeostasis Calcium and phosphate are the major mineral constituents of bone. They are also two of the most important minerals
More informationAwaisheh. Mousa Al-Abbadi. Abdullah Alaraj. 1 Page
f #3 Awaisheh Abdullah Alaraj Mousa Al-Abbadi 1 Page *This sheet was written from Section 1 s lecture, in the first 10 mins the Dr. repeated all the previous material relating to osteoporosis from the
More informationG-Protein Signaling. Introduction to intracellular signaling. Dr. SARRAY Sameh, Ph.D
G-Protein Signaling Introduction to intracellular signaling Dr. SARRAY Sameh, Ph.D Cell signaling Cells communicate via extracellular signaling molecules (Hormones, growth factors and neurotransmitters
More informationBone Remodeling & Repair Pathologies
Bone Remodeling & Repair Pathologies Skeletal system remodels itself to maintain homeostasis Remodeling Maintainence replaces mineral reserves (osteocytes) of the matrix Remodelling recycles (osteoclasts)
More informationHypocalcemia 6/8/12. Normal value. Physiologic functions. Nephron a functional unit of kidney. Influencing factors in Calcium and Phosphate Balance
Normal value Hypocalcemia Serum calcium Total mg/dl Ionized mg/dl Cord blood 9.0 ~ 11.5 5.0 ~ 6.o New born (1 st 24 hrs) 9.0 ~ 10.6 4.3 ~ 5.1 24~ 48 hrs 7.0 ~12.0 4.0 ~4.7 Child 8.8 ~10.8 4.8 ~4.92 There
More informationPropagation of the Signal
OpenStax-CNX module: m44452 1 Propagation of the Signal OpenStax College This work is produced by OpenStax-CNX and licensed under the Creative Commons Attribution License 3.0 By the end of this section,
More informationThe Endocrine System. I. Overview of the Endocrine System. II. Three Families of Hormones. III. Hormone Receptors. IV. Classes of Hormone Receptor
The Endocrine System I. Overview of the Endocrine System A. Regulates long term metabolic processes B. Releases hormones from endocrine cells 1. Hormones are chemicals 2. Alter metabolism of cells 3. Release
More informationChapter 6: SKELETAL SYSTEM
Chapter 6: SKELETAL SYSTEM I. FUNCTIONS A. Support B. Protection C. Movement D. Mineral storage E. Lipid storage (Fig. 6.8b) F. Blood cell production (Fig. 6.4) II. COMPONENTS A. Cartilage 1. Hyaline 2.
More informationSKELETAL SYSTEM I NOTE: LAB ASSIGNMENTS for this topic will run over 3 Weeks. A SEPARATE WORKSHEET WILL BE PROVIDED.
BIO 211; Anatomy and Physiology I REFERENCE: CHAPTER 07 1 Dr. Lawrence Altman Naugatuck Valley Community College LECTURE TOPICS OUTLINE SKELETAL SYSTEM I NOTE: LAB ASSIGNMENTS for this topic will run over
More information2402 : Anatomy/Physiology
Dr. Chris Doumen Lecture 2 2402 : Anatomy/Physiology The Endocrine System G proteins and Adenylate Cyclase /camp TextBook Readings Pages 405 and 599 through 603. Make use of the figures in your textbook
More informationGeneral Principles of Endocrine Physiology
General Principles of Endocrine Physiology By Dr. Isabel S.S. Hwang Department of Physiology Faculty of Medicine University of Hong Kong The major human endocrine glands Endocrine glands and hormones
More informationChapter 11 - Endocrine System
Chapter 11 - Endocrine System 11.1 Introduction A. The endocrine system is made up of the cells, tissues, and organs that secrete hormones into body fluids. B. The body has two kinds of glands, exocrine
More informationRegulation of the skeletal mass through the life span
Regulation of the skeletal mass through the life span Functions of the skeletal system Mechanical protection skull Movement leverage for muscles Mineral metabolism calcium store Erythropoiesis red blood
More informationPARATHYROID, VITAMIN D AND BONE
PARATHYROID, VITAMIN D AND BONE G M Kellerman Pathology North Hunter Service 30/01/2015 BIOLOGY OF BONE Bone consists of protein, polysaccharide components and mineral matrix. The mineral is hydroxylapatite,
More informationChapter 16: Endocrine System 1
Ch 16 Endocrine System Bi 233 Endocrine system Endocrine System: Overview Body s second great controlling system Influences metabolic activities of cells by means of hormones Slow signaling Endocrine glands
More informationNotes to/6 4- ( ea/2
Notes to/6 4- ( 0 1 -. ea/2 PART Two FACTORS AFFECTING BONE DEVELOPMENT & GROWTH Nutrition There must be adequate intake of certain nutrients, such as: 1. Calcium 2. Vitamin C : Necessary for collagen
More informationb. Adult bones produce 2.5 million RBCs each second.
Ch 6 Skeletal System I. Functions of the Skeletal System A. The skeletal system consists of: 1. bones, cartilage, tendons and ligaments B. Living bone is not Gr. dried up 1. It is dynamic and adaptable
More information25/10/56. Hypothyroidism Myxedema in adults Cretinism congenital deficiency of thyroid hormone Hashimoto thyroiditis. Simple goiter (nontoxic goiter)
THERAPEUTIC USES OF THYROID HORMONE Supeecha Wittayalertpunya Wannarasmi Ketchart Nov 2013 Hyperthyroidism (Thyrotoxicosis) Grave s disease (diffuse toxic goiter) Toxic uninodular & Toxic multinodular
More informationREGULATION OF CALCIUM AND PHOSPHATE HOMEOSTASIS
REGULATION OF CALCIUM AND PHOSPHATE HOMEOSTASIS Linda S. Costanzo Virginia Commonwealth University, Medical College of Virginia, Richmond, Virginia 23298 Teaching Ca 2 and phosphate homeostasis in a physiology
More informationDavid Bruyette, DVM, DACVIM
VCAwestlaspecialty.com David Bruyette, DVM, DACVIM Disorders of calcium metabolism are common endocrine disorders in both dogs and cats. In this article we present a logical diagnostic approach to patients
More informationInvestigations for Disorders of Calcium, Phosphate and Magnesium Homeostasis
Investigations for Disorders of Calcium, Phosphate and Magnesium Homeostasis Tutorial for Specialist Portfolio Biomedical Scientists 03/02/2014 Dr Petros Kampanis Clinical Scientist 1. Calcium Most abundant
More informationThe Role of the Laboratory in Metabolic Bone Disease
The Role of the Laboratory in Metabolic Bone Disease Howard Morris PhD, FAACB, FFSc(RCPA) President, IFCC Professor of Medical Sciences, University of South Australia, Clinical Scientist, SA Pathology
More informationRevision. camp pathway
االله الرحمن الرحيم بسم Revision camp pathway camp pathway Revision camp pathway Adenylate cyclase Adenylate Cyclase enzyme Adenylate cyclase catalyses the formation of camp from ATP. Stimulation or inhibition
More informationMECHANISM AND MODE OF HORMONE ACTION. Some definitions. Receptor: Properties of receptors. PRESENTED BY MBUNKUR GLORY NKOSI.
MECHANISM AND MODE OF HORMONE ACTION. PRESENTED BY MBUNKUR GLORY NKOSI. OUTLINE. Introduction Some definitions Hormone secretion, transport, and clearance from the blood. Feedback control of hormone secretion.
More informationChapter 13 Endocrine System. Endocrine System. Endocrine System Functions
Chapter 13 Endocrine System Endocrine glands are ductless Exocrine glands have ducts 1 Endocrine System composed of cells, tissues and organs that secrete substances into the internal environment Hormones
More informationOSSEOUS TISSUE & BONE STRUCTURE PART I: OVERVIEW & COMPONENTS
OSSEOUS TISSUE & BONE STRUCTURE PART I: OVERVIEW & COMPONENTS The Skeletal System Skeletal system includes: bones of the skeleton, cartilages, ligaments, and connective tissues What are the functions of
More informationChapter 13 Endocrine System. Endocrine System. Endocrine Glands. Comparison of Nervous System and Endocrine System
Endocrine glands are ductless Exocrine glands have ducts Chapter 13 Endocrine System 1 Endocrine System composed of cells, tissues and organs that secrete substances into the internal environment Hormones
More informationAn Introduction to the Skeletal System Skeletal system includes Bones of the skeleton Cartilages, ligaments, and connective tissues
An Introduction to the Skeletal System Skeletal system includes Bones of the skeleton Cartilages, ligaments, and connective tissues Functions of the Skeletal System Support Storage of minerals (calcium)
More informationBCOR 011 Lecture 19 Oct 12, 2005 I. Cell Communication Signal Transduction Chapter 11
BCOR 011 Lecture 19 Oct 12, 2005 I. Cell Communication Signal Transduction Chapter 11 External signal is received and converted to another form to elicit a response 1 Lecture Outline 1. Types of intercellular
More informationWhat is the right calcium balance?
For patients with hypoparathyroidism What is the right calcium balance? Indications and Usage1 NATPARA is a parathyroid hormone indicated as an adjunct to calcium and vitamin D to control hypocalcemia
More informationOsama Zoubi (OZ) - Saleem
-5 م ها أبو عجمي ة Osama Zoubi (OZ) - Saleem Bone Remodelling: the process of bones deposition -building- and resorption -breaking-, it involves the interplay between bone-building cells (osteoblasts)
More informationThe Skeletal Response to Aging: There s No Bones About It!
The Skeletal Response to Aging: There s No Bones About It! April 7, 2001 Joseph E. Zerwekh, Ph.D. Interrelationship of Intestinal, Skeletal, and Renal Systems to the Overall Maintenance of Normal Calcium
More informationThe endoplasmic reticulum is a network of folded membranes that form channels through the cytoplasm and sacs called cisternae.
Endoplasmic reticulum (ER) The endoplasmic reticulum is a network of folded membranes that form channels through the cytoplasm and sacs called cisternae. Cisternae serve as channels for the transport of
More informationThyroid and parathyroid glands
Thyroid and parathyroid glands Dr. Isabel Hwang Department of Physiology Faculty of Medicine University of Hong Kong May 2007 The thyroid gland straddles the esophagus, just below the larynx, in the neck.
More informationAmani Alghamdi. Slide 1
Minerals in the body Amani Alghamdi Slide 1 The Minerals Small, naturally occurring, inorganic, chemical elements Serve as structural components Minerals classification The minerals present in the body
More informationEndocrine secretion cells secrete substances into the extracellular fluid
Animal Hormones Concept 30.1 Hormones Are Chemical Messengers Endocrine secretion cells secrete substances into the extracellular fluid Exocrine secretion cells secrete substances into a duct or a body
More informationCell Communication. Chapter 11. Biology Eighth Edition Neil Campbell and Jane Reece. PowerPoint Lecture Presentations for
Chapter 11 Cell Communication PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions from Joan Sharp
More informationCKD: Bone Mineral Metabolism. Peter Birks, Nephrology Fellow
CKD: Bone Mineral Metabolism Peter Birks, Nephrology Fellow CKD - KDIGO Definition and Classification of CKD CKD: abnormalities of kidney structure/function for > 3 months with health implications 1 marker
More informationSignal Transduction: G-Protein Coupled Receptors
Signal Transduction: G-Protein Coupled Receptors Federle, M. (2017). Lectures 4-5: Signal Transduction parts 1&2: nuclear receptors and GPCRs. Lecture presented at PHAR 423 Lecture in UIC College of Pharmacy,
More informationEndocrine System. Always willing to lend a helping gland
Endocrine System Always willing to lend a helping gland Functions of the Endocrine System Regulates metabolic activities through hormones Controls reproduction, growth and development, cellular metabolism,
More informationAcid-Base Balance 11/18/2011. Regulation of Potassium Balance. Regulation of Potassium Balance. Regulatory Site: Cortical Collecting Ducts.
Influence of Other Hormones on Sodium Balance Acid-Base Balance Estrogens: Enhance NaCl reabsorption by renal tubules May cause water retention during menstrual cycles Are responsible for edema during
More informationChapter 11. Endocrine System
Chapter 11 Endocrine System 1 Introduction A. The endocrine system is made up of the cells, tissues, and organs that secrete hormones into body fluids. B. Hormones diffuse into the bloodstream to act target
More informationPersistent post transplant hyperparathyroidism. Shiva Seyrafian IUMS-97/10/18-8/1/2019
Persistent post transplant hyperparathyroidism Shiva Seyrafian IUMS-97/10/18-8/1/2019 normal weight =18-160 mg In HPT= 500-1000 mg 2 Epidemiology Mild 2 nd hyperparathyroidism (HPT) resolve after renal
More informationMagnesium Homeostasis
ECTS PhD Training Course, Rome 3 rd September 2008 Disorders of Calcium, Phosphate h and Magnesium Homeostasis Richard Eastell Professor of Bone Metabolism Academic Unit of Bone Metabolism University of
More informationThe Endocrine System. PowerPoint Lecture Presentations prepared by Jason LaPres. Lone Star College North Harris
18 The Endocrine System PowerPoint Lecture Presentations prepared by Jason LaPres Lone Star College North Harris NOTE: Presentations extensively modified for use in MCB 244 & 246 at the University of Illinois
More informationCALCIUM AND THYROID METABOLISM. Westmead Primary Exam Group
CALCIUM AND THYROID METABOLISM Westmead Primary Exam Group THYROID HORMONES Chemistry - principle hormones are: T3 (Triiodothyronine) Can be formed in peripheral tissues by de-iodination of T4 T3 is more
More informationCalcium, phosphate & magnesium regulation
Calcium, phosphate & magnesium regulation Tim Arnett Department of Cell and Developmental Biology University College London Bone composition Treated with hydrochloric acid to dissolve mineral leaves organic
More informationDrugs Affecting Bone. Rosa McCarty PhD. Department of Pharmacology & Therapeutics
Drugs Affecting Bone Rosa McCarty PhD Department of Pharmacology & Therapeutics rmccarty@unimelb.edu.au Objectives At the end of this lecture you should have gained: An understanding of bone metabolism
More informationSkeletal. Parathyroid hormone-related protein Analyte Information
Skeletal Parathyroid hormone-related protein Analyte Information 1 2012-04-04 Parathyroid hormone related protein (PTHrP) Introduction Parathyroid hormone-related protein (PTHrP) is actually a family of
More information1. to understand how proteins find their destination in prokaryotic and eukaryotic cells 2. to know how proteins are bio-recycled
Protein Targeting Objectives 1. to understand how proteins find their destination in prokaryotic and eukaryotic cells 2. to know how proteins are bio-recycled As a protein is being synthesized, decisions
More informationCalcium and Parathyroid Disorders
Calcium and Parathyroid Disorders Hussain Mahmud, MD Clinical Assistant Professor of Medicine Division of Endocrinology, Diabetes, and Metabolism University of Pittsburgh Butler Memorial Hospital November
More informationBiochemistry #01 Bone Formation Dr. Nabil Bashir Farah Banyhany
Biochemistry #01 Bone Formation Dr. Nabil Bashir Farah Banyhany Greetings This lecture is quite detailed, but I promise you will make it through, it just requires your 100% FOCUS! Let s begin. Today s
More informationGLOSSARY OF TERMS. produced in response to an antigen to bond with and neutralize that antigen / the body's way of destroying foreign invaders
TERM 24-hour urine acidosis acquired aemia (prefix) albumin alkalosis anemia antibodies antigen autocrine autoimmune basal ganglion bone turnover calcilytic calcimimetic calcitonin Calcitriol Calcium carbonate
More informationBiochemistry. Vitamin D, Rickets and Osteoporosis. Editing file. One day you ll be person between the patient and his grief. Please study well..
HbA NH2 H2 O2 Cl2O7 KClO3 CH2O PO4 NAOH KMnO4 MEDICINE COOH KING SAUD UNIVERSITY Co2 MgCl2 H 2O SO2 Doctors slides Important Extra Information Doctors notes Biochemistry Vitamin D, Rickets and Osteoporosis
More informationEndocrine Notes Mrs. Laux AP Biology I. Endocrine System consists of endocrine glands (ductless), cells, tissues secrete hormones
I. Endocrine System consists of endocrine glands (ductless), cells, tissues secrete hormones regulates metabolism, fluid balance, growth, reproduction A. Hormones 1. chemical signals-cell to cell communication
More informationOsseous Tissue and Bone Structure
C h a p t e r 6 Osseous Tissue and Bone Structure PowerPoint Lecture Slides prepared by Jason LaPres Lone Star College - North Harris Copyright 2009 Pearson Education, Inc., publishing as Pearson Benjamin
More informationHYPERCALCEMIA. Babak Tamizi Far MD. Assistant professor of internal medicine Al-zahra hospital, Isfahan university of medical sciences
HYPERCALCEMIA Babak Tamizi Far MD. Assistant professor of internal medicine Al-zahra hospital, Isfahan university of medical sciences ESSENTIALS OF DIAGNOSIS Serum calcium level > 10.5 mg/dl Serum ionized
More informationReceptor mediated Signal Transduction
Receptor mediated Signal Transduction G-protein-linked receptors adenylyl cyclase camp PKA Organization of receptor protein-tyrosine kinases From G.M. Cooper, The Cell. A molecular approach, 2004, third
More informationLipids and Membranes
Lipids and Membranes Presented by Dr. Mohammad Saadeh The requirements for the Pharmaceutical Biochemistry I Philadelphia University Faculty of pharmacy Membrane transport D. Endocytosis and Exocytosis
More informationDR. DARWISH H. BADRAN. Parathyroid glands
Parathyroid glands History 1849 - Sir Richard owen provided 1st accurate description of normal parathyroid glands after examining Indian Rhinoceros 1879 - Anton Wölfer described tetany in a patient
More informationIntroduction! Introduction! Introduction! Chem Lecture 10 Signal Transduction & Sensory Systems Part 2
Chem 452 - Lecture 10 Signal Transduction & Sensory Systems Part 2 Questions of the Day: How does the hormone insulin trigger the uptake of glucose in the cells that it targets. Introduction! Signal transduction
More informationFigures and tables in this presentation were adopted from various printed and electronic resorces and serve strictly for educational purposes.
Academic lectures 3rd year of Medical faculty Figures and tables in this presentation were adopted from various printed and electronic resorces and serve strictly for educational purposes. ENDOCRINOLOGY
More information2402 : Anatomy/Physiology
Dr. Chris Doumen Lecture 4 2402 : Anatomy/Physiology Major Endocrine Organs Calci u m H o me os t asis TextBook Readings Pages 624 through 632. Make use of the figures in your textbook ; a picture is worth
More informationChapter 11. Cell Communication
Chapter 11 Cell Communication Overview: The Cellular Internet Cell-to-cell communication Is absolutely essential for multicellular organisms Concept 11.1: External signals are converted into responses
More informationThyroid, antithyroid, parathyroid & Calcium metabolism. Suharti K Suherman Dept. of Pharmacology & Therapeutic Medical Faculty, Univ.
Thyroid, antithyroid, parathyroid & Calcium metabolism Suharti K Suherman Dept. of Pharmacology & Therapeutic Medical Faculty, Univ. of Indonesia Thyroid secreted by thyroid gland source of 2 different
More informationCHAPTER II PDL 101 HUMAN ANATOMY & PHYSIOLOGY. Ms. K. GOWRI. M.Pharm., Lecturer.
CHAPTER II PDL 101 HUMAN ANATOMY & PHYSIOLOGY Ms. K. GOWRI. M.Pharm., Lecturer. Structure of cell: Human body develops from a single cell zygote which results from fusion of the ovum andd the spermatozoan.
More informationCell Signaling part 2
15 Cell Signaling part 2 Functions of Cell Surface Receptors Other cell surface receptors are directly linked to intracellular enzymes. The largest family of these is the receptor protein tyrosine kinases,
More informationPRIMARY HYPERPARATHYROIDISM
PRIMARY HYPERPARATHYROIDISM HYPERPARATHYROIDISM Inappropriate excess secretion of Parathyroid Hormone in Primary Hyperparathyroidism Appropriate Hypersecretion in Secondary Hyperparathyroidism PTH and
More informationHORMONES (Biomedical Importance)
hormones HORMONES (Biomedical Importance) Hormones are the chemical messengers of the body. They are defined as organic substances secreted into blood stream to control the metabolic and biological activities.
More informationClose to site of release (at synapse); binds to receptors in
Chapter 18: The Endocrine System Chemical Messengers 1. Neural 2. Endocrine 3. Neuroendocrine 4. Paracrine 5. Autocrine Endocrine System --Endocrine and nervous systems work together --Endocrine vs. Nervous
More informationGENERAL CHARACTERISTICS OF THE ENDOCRINE SYSTEM FIGURE 17.1
GENERAL CHARACTERISTICS OF THE ENDOCRINE SYSTEM FIGURE 17.1 1. The endocrine system consists of glands that secrete chemical signals, called hormones, into the blood. In addition, other organs and cells
More informationCh 11: Endocrine System
Ch 11: Endocrine System SLOs Describe the chemical nature of hormones and define the terms proand prepro-hormone. Explain mechanism of action of steroid and thyroid hormones Create chart to distinguish
More informationChapter 9. The Endocrine System. Lecture Presentation by Patty Bostwick-Taylor Florence-Darlington Technical College Pearson Education, Inc.
Chapter 9 The Endocrine System Lecture Presentation by Patty Bostwick-Taylor Florence-Darlington Technical College Intro to the Endocrine System Chief Complaint:8-year-old girl with excessive thirst, frequent
More informationCell Communication. Chapter 11. PowerPoint Lectures for Biology, Seventh Edition. Lectures by Chris Romero. Neil Campbell and Jane Reece
Chapter 11 Cell Communication PowerPoint Lectures for Biology, Seventh Edition Neil Campbell and Jane Reece Lectures by Chris Romero Overview: The Cellular Internet Cell-to-cell communication Is absolutely
More informationSignal Transduction Cascades
Signal Transduction Cascades Contents of this page: Kinases & phosphatases Protein Kinase A (camp-dependent protein kinase) G-protein signal cascade Structure of G-proteins Small GTP-binding proteins,
More informationCellular Messengers. Intracellular Communication
Cellular Messengers Intracellular Communication Most common cellular communication is done through extracellular chemical messengers: Ligands Specific in function 1. Paracrines Local messengers (neighboring
More informationChapter 20. Cell - Cell Signaling: Hormones and Receptors. Three general types of extracellular signaling. endocrine signaling. paracrine signaling
Chapter 20 Cell - Cell Signaling: Hormones and Receptors Three general types of extracellular signaling endocrine signaling paracrine signaling autocrine signaling Endocrine Signaling - signaling molecules
More informationGoals and Challenges of Communication. Communication and Signal Transduction. How Do Cells Communicate?
Goals and Challenges of Communication Reaching (only) the correct recipient(s) Imparting correct information Timeliness Causing the desired effect Effective termination Communication and Signal Transduction
More informationCHAPTER 27 LECTURE OUTLINE
CHAPTER 27 LECTURE OUTLINE I. INTRODUCTION A. Body fluid refers to body water and its dissolved substances. B. Regulatory mechanisms insure homeostasis of body fluids since their malfunction may seriously
More informationANATOMY & PHYSIOLOGY - CLUTCH CH. 6 - CELL COMMUNICATION.
!! www.clutchprep.com CONCEPT: CELL-TO-CELL CONNECTIONS AND SIGNALING Gap and Tight Junctions: Adjacent cells communicate and hold on to each other via junctions. Two important kinds: Gap Junctions are
More informationChapter 26 Fluid, Electrolyte, and Acid- Base Balance
Chapter 26 Fluid, Electrolyte, and Acid- Base Balance 1 Body Water Content Infants: 73% or more water (low body fat, low bone mass) Adult males: ~60% water Adult females: ~50% water (higher fat content,
More informationBIOLOGY - CLUTCH CH.45 - ENDOCRINE SYSTEM.
!! www.clutchprep.com Chemical signals allow cells to communicate with each other Pheromones chemical signals released to the environment to communicate with other organisms Autocrine signaling self-signaling,
More informationArt labeling Activity: Figure 16.1
ANP 1105D Winter 2013 Assignment 6 part I: The Endocrine Sy... Assignment 6 part I: The Endocrine System, Chapter 16 Due: 11:59pm on Monday, March 4, 2013 Note: To understand how points are awarded, read
More informationThe Skeletal System:Bone Tissue
The Skeletal System:Bone Tissue Dynamic and ever-changing throughout life Skeleton composed of many different tissues cartilage, bone tissue, epithelium, nerve, blood forming tissue, adipose, and dense
More informationThe Endocrine System. The Endocrine System
The Endocrine System Like nervous system, endocrine system provides communication and control. Messages are relayed from one cell to another via chemical messengers (hormones). Unlike nervous system which
More informationhypercalcemia of malignancy hyperparathyroidism PHPT the most common cause of hypercalcemia in the outpatient setting the second most common cause
hyperparathyroidism A 68-year-old woman with documented osteoporosis has blood tests showing elevated serum calcium and parathyroid hormone (PTH) levels: 11.2 mg/dl (8.8 10.1 mg/dl) and 88 pg/ml (10-60),
More informationCell Communication. Biology Eighth Edition Neil Campbell and Jane Reece. PowerPoint Lecture Presentations for
Chapter 11 Cell Communication PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions from Joan Sharp
More information