Perinatal factors associated with neonatal thyroidstimulating hormone in normal newborns
|
|
- Silas Matthews
- 6 years ago
- Views:
Transcription
1 Original article Ann Pediatr Endocrinol Metab 2016;21: Perinatal factors associated with neonatal thyroidstimulating hormone in normal newborns Seong Yong Lee, MD Department of Pediatrics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea Purpose: This study was to evaluate the effect of neonatal, maternal, and delivery factors on neonatal thyroid-stimulating hormone (TSH) of healthy newborns. Methods: Medical records of 705 healthy infants born through normal vaginal delivery were reviewed. Neonatal TSH levels obtained by neonatal screening tests were analyzed in relation to perinatal factors and any associations with free thyroxine (FT4) and 17-α hydroxyprogesterone (17OHP) levels. Results: An inverse relationship was found between TSH and sampling time after birth. Twin babies and neonates born by vacuum-assisted delivery had higher TSH levels than controls. First babies had higher TSH levels than subsequent babies. Birth weight, gestational age, maternal age and duration from the rupture of the membrane to birth were not related to neonatal TSH. There were no significant differences in TSH level according to sex, Apgar scores, labor induction, the presence of maternal disease and maternal medications. There was a positive association between TSH and 17OHP level but not between TSH and FT4 level. Multiple linear regression analyses showed that sampling time, mode of delivery, birth order, and 17OHP level were significant factors affecting neonatal TSH level. Conclusion: Neonatal TSH levels of healthy normal newborns are related with multiple factors. Acute stress during delivery may influence the neonatal TSH level in early neonatal period. Keywords: Thyrotropin, Neonatal screening, Newborn infant Introduction Received: 17 September, 2016 Revised: 18 October, 2016 Accepted: 9 November, 2016 Address for correspondence: Seong Yong Lee, MD Department of Pediatrics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul 07061, Korea Tel: Fax: gnoygnoes@hanmail.net Thyroid hormone is essential for somatic growth and neurodevelopment. Early infancy is a critical period in which adequate levels of thyroid hormone are required for normal brain development. Otherwise, irreversible neurological sequelae will ensue 1,2). Therefore, early diagnosis and proper treatment for congenital hypothyroidism (CH) are important to prevent deleterious consequences such as mental retardation and growth failure 3). As it is difficult to diagnose CH with clinical symptoms at birth, most patients with CH were diagnosed by laboratory results; low serum thyroid hormones and high serum thyroidstimulating hormone (TSH) levels except for central hypothyroidism. To avoid a delayed diagnosis, a neonatal screening test (NST) using capillary blood has been introduced in many countries. In Korea, a neonatal screening program for CH was initiated early in the 1990s 4). Most centers in Korea evaluate TSH levels but some examine both TSH and free thyroxine (FT4) levels to screen for CH. If the TSH level is above the cutoff level at initial NST, a repeat NST or an evaluation of serum levels of TSH will be done. Thus, the initial neonatal TSH level is an important clue to decide on further evaluation and initiation of treatment. TSH level is influenced by various factors 5-8). However, some of the results are controversial and most of these studies investigated subjects including neonates with pathologic or This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ISSN: (Print) ISSN: (Online) 2016 Annals of Pediatric Endocrinology & Metabolism
2 abnormal conditions, such as preterm and sick babies. Prematurity itself, neonatal illness, and neonatal and maternal medications may influence neonatal TSH and thyroid hormone levels 5-7,9) This study aimed to evaluate perinatal factors affecting neonatal TSH of healthy neonates born through normal vaginal delivery, excluding the effects of severe neonatal problems such as prematurity and pathologic conditions. Materials and methods 1. Subjects We performed a retrospective review of the medical records of 726 babies who were born through normal vaginal delivery at Seoul Metropolitan Government Seoul National University (SMG-SNU) Boramae Medical Center, Seoul, Korea from January 2013 to December 2014 and discharged from the nursery. Of 726 newborns, 4 had a TSH level above 10 miu/ ml, which is the cutoff level for reevaluation. Follow-up TSH levels were at normal levels in 3 of them and they were included in this study. One of the 4 infants whose TSH levels were above 10 miu/ml was diagnosed with CH. Two infants whose initial TSH levels were at normal levels had been taking thyroid hormone replacement under the suspicion of CH or transient TSH elevation. Seven infants whose sampling time was before 24 hours after birth and one baby whose sampling time was after 96 hours after birth were excluded. Ten neonates had congenital anomalies or perinatal problems (2 congenital heart disease, 3 renal anomaly, 1 syndactyly, 1 achondroplasia, 1 pineal cyst, 1 chromosomal anomaly, and 1 hypocalcemia). After excluding these 10 infants, 8 infants whose sampling time was early or late, and 3 others who were diagnosed with or suspected of having CH, 705 subjects were included in this study. 2. Methods Dried capillary blood spots were obtained by heel prick to measure TSH, FT4, and 17-α hydroxyprogesterone (17OHP) levels. Neonatal TSH levels were measured using an AutoDELFIA Neonatal htsh kit (PerkinElmer, Waltham, MA, USA). Neonatal FT4 levels were measured using Microplate Neonatal FT4 (Bio-Rad, Hercules, CA, USA). An AutoDELFIA Neonatal 17a-OH-progesterone kit (PerkinElmer, Waltham, MA, USA) was used to measure neonatal 17OHP levels. The normal levels of NST were as follows; TSH <10.0 miu/ ml; FT4 >0.7 ng/dl; 17OHP <12.0 ng/ml. Data on various factors were collected. Infant-related factors included sex, gestational age, birth weight, birth length, head circumference, sampling time, and Apgar scores (ASs). Deliveryrelated factors included mode of delivery, labor induction, and duration of the rupture of the membrane (ROM). Maternal factors included twin delivery, parity, maternal age, maternal disease, and maternal medication. Neonatal TSH levels were analyzed in relation to these perinatal factors and any associations with FT4 and 17 OHP levels. 3. Statistics Statistical analyses were performed with IBM SPSS version 20.0 (IBM Co., Armonk, NY, USA). Variables were tested for a normal distribution. Levels of TSH, FT4, and 17OHP were logtransformed to normalize each distribution. Student t-test was used to compare TSH levels according to differences in perinatal factors. Pearson correlation analysis and stepwise linear regression analysis were applied to evaluate the relationship between TSH levels and continuous variables. A P-value of <0.05 was considered statistically significant. Table 1. Descriptive data on the subjects Variable Mean±SD Range TSH (µiu/ml) 3.78± FT4 (ng/dl) 2.36± OHP (ng/ml) 3.54± Gestational age (wk) 38.86± Birth weight (kg) 3.10± Birth length (cm) 49.85± Head circumference (cm) 33.77± Maternal age (yr) 32.69± Apgar score at 1 min 7.90± Apgar score at 5 min 8.94± Sampling time (hr) 44.69± Duration of ROM (hr) 5.28±9.09 < SD, standard deviation; TSH, thyroid stimulating hormone; FT4, free thyroxine; 17OHP, 17-α hydroxyprogesterone; ROM, rupture of membrane. Table 2. Pearson correlation analysis between TSH and perinatal factors Variable TSH lntsh r P-value r P-value Gestational age Birth weight Birth length Head circumference Sample time ROM Maternal age OHP < <0.001 ln17ohp < <0.001 FT lnft TSH, thyroid stimulating hormone; lntsh, log transformed TSH; 17OHP, 17-α hydroxyprogesterone; ln17ohp, log transformed 17OHP; FT4, free thyroxine; lnft4, log transformed free T4; ROM, rupture of membrane
3 4. Ethics statement This study was approved by the Institutional Review Board of SMG-SNU Boramae Medical Center (IRB No /081). Informed consent was waived by the Board. Results Clinical data and results of NSTs are shown in Table 1. TSH and 17OHP levels were examined in 705 newborns and FT4 was analyzed in 610 newborns. Of 705 neonates, 3 had an abnormal level of 17OHP (>12.0 ng/ml) initially and a normal level subsequently. Of 610 newborns, no one had an abnormal FT4 level. 1. Infant factors Log transformed TSH level (lntsh) was not related to gestational age, birth weight, birth length, or head circumference at birth (Table 2). There were no significant differences in TSH level according to the sex of the baby (Table 3). When subjects were divided into 2 groups by AS at 1 minute (<7 vs. 7) and at 5 minutes (<9 vs. 9), there were no differences in TSH level between the 2 groups (Table 3). Table 3. Comparison of TSH level according to perinatal factors Variable No. (%) TSH P-value lntsh P-value Sex Male 373 (52.9) 3.85± ±0.52 Female 332 (47.1) 3.69± ± Multiple delivery Singleton 679 (96.3) 3.75± ±0.52 Twin 26 (3.7) 4.57± ± Birth order 1st baby 433 (61.4) 3.89± ±0.49 2nd or later baby 272 (38.6) 3.60± ± Apgar score at 1 min <7 18 (2.6) 3.56± ± (97.4) 3.78± ± Apgar score at 5 min 7, 8 65 (9.2) 4.12± ±0.50 9, (90.8) 3.74± ± Delivery type Spontaneous 571 (81.0) 3.72± ±0.53 Vacuum assisted 134 (19.0) 4.01± ± Labor type Spontaneous 218 (30.9) 3.60± ±0.52 Induced 487 (69.1) 3.85± ± Maternal diabetes Normal 653 (92.6) 3.75± ±0.52 GDM/DM 52 (7.4) 4.14± ± Maternal hypertension Normal 688 (97.6) 3.77± ±0.52 PIH 17 (2.4) 4.00± ± Maternal thyroid disease Normal 646 (91.6) 3.76± ±0.53 Hypothyroidism a) 52 (7.4) 3.98± ± Hyperthyroidism a) 7 (1.0) 3.71± ± Maternal medication None 587 (83.3) 3.78± ±0.52 Insulin b) 22 (3.1) 3.79± ± L-thyroxine b) 41 (5.8) 4.07± ± Steroid b) 2 (0.0) 2.55± ± Values are presented as mean±standard deviation unless otherwise indicated. TSH, thyroid stimulating hormone; lntsh, log transformed TSH; GDM, gestational diabetes mellitus; DM, diabetes mellitus; PIH, pregnancy induced hypertension. a) Maternal thyroid diseases in comparison with normal thyroid function. b) Maternal medication in comparison with no medication
4 An inverse relationship was found between lntsh and sampling time after birth (r=-0.100, P=0.008) (Table 2). There was a positive association between lntsh and log transformed 17OHP level (ln17ohp) (r=0.22, P<0.001) (Table 2) but not between lntsh and log transformed FT4 level (lnft4) (Table 2). 2. Delivery factors Infants born by vacuum-assisted delivery had higher lntsh values than those born by spontaneous vaginal delivery (P=0.048) (Table 3). There were no significant differences in lntsh according to labor induction (Table 3). Duration from ROM to birth was not associated with lntsh (Table 2). 3. Maternal factors Maternal age was not related to lntsh (Table 2). Twin newborns had higher values than singleton babies (P=0.026) (Table 3), and first babies had higher values than subsequent babies (P=0.011) (Table 3). There were no significant differences in TSH level according to the presence of maternal disease such as diabetes, hypertension, and thyroid disease. In addition, TSH level did not differ according to any medications being taken by mothers, such as insulin and L-thyroxine (Table 3). 4. Stepwise multiple linear regression In stepwise multiple linear regression analyses including twin delivery, mode of delivery, birth order, sampling time, and ln17ohp as independent variables and lntsh as the dependent variable, mode of delivery, birth order, sampling time, and ln17ohp were significant factors affecting lntsh (Table 4). Discussion This study showed that the TSH level of normal neonates born through vaginal delivery was influenced by mode of delivery and birth order. Vacuum-assistance delivery and first delivery were associated with higher neonatal TSH levels compared to spontaneous delivery and being a second or later child. TSH levels had a positive relationship with 17OHP levels Table 4. Stepwise multiple linear regression analysis examining the influence of perinatal factors on variation in lntsh Variable Coefficient SE P-value (Constant) <0.001 ln 17OHP < st baby a) Sample time Vacuum delivery b) lntsh, log transformed TSH; SE, standard error; ln17ohp, log transformed 17-α hydroxyprogesterone. a) 1st baby in comparison with 2nd or later baby. b) Vacuum assisted delivery in comparison with normal spontaneous delivery. and a negative relationship with sampling time, and were not related to neonatal FT4 levels. Previous studies have reported that TSH levels in cord blood are higher in infants born through vaginal delivery than in those born through cesarean section 5,6,10-13), and higher in those born through vacuum-assisted delivery than in those born through spontaneous vaginal delivery 6,10,14). Our results support these studies, although we investigated capillary blood TSH, not cord blood TSH, and infants born through cesarean section were excluded. In contrast, two studies have shown no difference in neonatal TSH level according to mode of delivery 8,15). However, the subjects in one study included preterm and sick babies, and the authors did not consider vacuum-assisted delivery 15). The other study also reported higher TSH levels in infants born with vacuum assistance compared to spontaneous vaginal delivery, although the difference was not significant 8). Therefore, vacuum-assisted delivery itself or the condition prompting vacuum assistance is likely to increase neonatal TSH levels. Many studies have reported that first babies have higher TSH levels than subsequent babies 6,7,12,14). In contrast, one study from Belgium (where iodine insufficiency is common) reported no differences in TSH level according to birth order 8). Herbstman et al. 6) assumed that this pattern might be related to environmental exposure, as some persistent chemicals are found at higher levels in firstborn children. In addition, the relatively more difficult labor associated with a first delivery compared to subsequent deliveries could increase TSH levels. Glucocorticoid treatment may decrease serum levels of TSH through a direct inhibitory effect on thyrotropin releasing hormone (TRH); however, chronic high-dose glucocorticoids or cortisol excess in severe Cushing's syndrome do not have a significant effect 16). 17OHP is a precursor of cortisol and its levels are higher in preterm and sick newborns 17). When levels are high in term newborns without congenital adrenal hyperplasia, it may reflect some sort of stress. Therefore, a positive relationship between 17OHP and TSH may imply that stress during labor increases neonatal levels of TSH. At birth, TSH levels surge in response to exposure to cold; they peak about 30 min after birth and then gradually decrease 18). Generally, NSTs are performed 2 days after vaginal birth and 4 or 5 days after cesarean section in Korea. The sampling time of NST depends on the duration of hospital stay of mother and baby. Thus, we excluded neonates born through cesarean section, whose sampling times were much later than those of neonates born through vaginal delivery, from this study. As expected, the later the sampling time, the lower the level of TSH in babies born through normal vaginal delivery. This result is in accordance with previous studies on preterm infants and term infants 7,19). Although the increased levels of FT4 after birth that we observed was due to increased levels of TRH and TSH, the lack of a correlation between TSH and FT4 implies an immature hypothalamic pituitary thyroid (HPT) axis in the early neonatal period. Blunted TSH surges and delayed elevation of TSH levels 209
5 are often observed in preterm babies who have an impaired hypothalamic pituitary responsiveness at birth 20). Term babies also may have an immaturity of HPT axis in the early neonatal period. However, further studies about HPT axis in normal term babies will be required. TSH level was not related to gestational age in this study. Many previous studies have reported that TSH levels increase with increasing gestational age 5,8,19, 21,22) ; however, an inverse relationship has also been reported 23), another study reported higher TSH levels in preterm than in term babies 6), and several other studies have reported no difference in TSH levels according to gestational age 10,13,15). Although some studies have reported that low birth weight is related to high TSH levels 6, 19, 22,23), we did not find any association between birth weight and TSH level, in line with two previous reports 7,15). Therefore, the relationship between TSH level and gestational age or birth weight seems to be different according to the study population. Twin delivery is generally related to relative low birth weight, low gestational age, and increased maternal and fetal stress during labor. In our study, twin babies had higher TSH levels than singletons, but the difference was not significant in multivariate analyses, in line with previous works 7,22). We did not find any significant differences in TSH level according to sex, in line with many previous studies 6,8,12,13,15,21,22). However, a few studies have reported higher TSH levels in boys 7,14). One study reported that neonates with asphyxia (AS at 1 minute<3, and 5 minutes<5) had higher TSH levels than neonates with 1 minute AS 8 and 5 minutes AS 9 9). Another study reported high TSH levels with 1 minute AS<6, but no difference in TSH level according to 5 minutes AS 5). In contrast, Herbstman et al. 6) reported that infants with 5 minutes AS<8 had higher TSH levels, but there were no differences in TSH level according to 1 minute AS. Some studies have reported no differences in TSH level according to AS 7,13,15), as we found. Subjects in this study were healthy normal babies with relatively high AS without birth asphyxia. Thus, they were a relatively homogeneous group in terms of AS. Besides, AS is related with an examiner's subjectivity. Few studies have examined the relationship between TSH and labor induction. One study reported that preterm neonates born after labor induction had higher TSH levels 7). Another study reported a relationship between TSH level and duration of labor 10). However, we did not find a relationship between TSH level and labor induction. The reason for these different results is unknown. However, maternal and fetal stress levels might not be different between spontaneous and induced labor. There was no relationship between TSH level and maternal age in our study, in line with most previous studies 6-8,12,13). Only one study has reported a positive relationship between maternal age and TSH level 22). The duration of ROM did not influence TSH level in this study. Few studies have examined this factor; one that did reported no relationship between TSH level and ROM, as we found 7). Maternal disease such as overt and gestational diabetes, essential or pregnancy-induced hypertension, and hyper- or hypothyroidism did not affect TSH levels, in agreement with many previous studies 6-8,12,14) and in disagreement with one study in which the authors reported an increased TSH level in maternal diabetes and preeclampsia 5). In addition, the use of medications to mothers did not affect TSH levels in our study. All of the infants in this study were born through a normal vaginal delivery. This means that any maternal diseases were well controlled with proper medications. These results suggest that a well-controlled maternal disease during pregnancy is not likely to influence neonatal TSH levels. Therefore, acute stress during labor may have caused the increases in TSH levels. There were some limitations to this study. First, this is a cross-sectional retrospective study. Second, the NST was not as accurate as that of a serologic test for assessing TSH levels. Third, all of the factors possibly affecting TSH levels were not analyzed. For example, maternal and fetal levels of iodine were not evaluated. Iodine deficiency of mother and fetus could cause CH or an elevation of TSH level. Factors not included in this study may influence neonatal TSH levels. Nonetheless, this study, conducted on normal babies without pathologic conditions, suggests that stress during labor may influence TSH levels even in normal newborns. In addition, this study is unique in that the relationship between neonatal TSH and 17OHP level was analyzed. In conclusion, TSH levels of healthy, normal newborns are related to multiple factors. Acute stress during delivery may influence the neonatal TSH level in the early neonatal period. We should consider various perinatal conditions when evaluating neonatal TSH levels. Conflict of interest No potential conflict of interest relevant to this article was reported. References 1. Bongers-Schokking JJ, de Muinck Keizer-Schrama SM. Influence of timing and dose of thyroid hormone replacement on mental, psychomotor, and behavioral development in children with congenital hypothyroidism. J Pediatr 2005;147: Grosse SD, Van Vliet G. Prevention of intellectual disability through screening for congenital hypothyroidism: how much and at what level? Arch Dis Child 2011;96: Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G, et al. European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. Horm Res Paediatr 2014;81: Lee DH. Newborn screening of inherited metabolic disease 210
6 in Korea. Korean J Pediatr 2006;49: Kim EY, Park SK, Song CH, Lim SC. Perinatal factors affecting thyroid stimulating hormone (TSH) and thyroid hormone levels in cord blood. Korean J Pediatr 2005;48: Herbstman J, Apelberg BJ, Witter FR, Panny S, Goldman LR. Maternal, infant, and delivery factors associated with neonatal thyroid hormone status. Thyroid 2008;18: Ryckman KK, Spracklen CN, Dagle JM, Murray JC. Maternal factors and complications of preterm birth associated with neonatal thyroid stimulating hormone. J Pediatr Endocrinol Metab 2014;27: Trumpff C, Vandevijvere S, Moreno-Reyes R, Vanderpas J, Tafforeau J, Van Oyen H, et al. Neonatal thyroid-stimulating hormone level is influenced by neonatal, maternal, and pregnancy factors. Nutr Res 2015;35: Pereira DN, Procianoy RS. Effect of perinatal asphyxia on thyroid-stimulating hormone and thyroid hormone levels. Acta Paediatr 2003;92: Miyamoto N, Tsuji M, Imataki T, Nagamachi N, Hirose S, Hamada Y. Influence of mode of delivery on fetal pituitarythyroid axis. Acta Paediatr Jpn 1991;33: McElduff A, McElduff P, Wiley V, Wilcken B. Neonatal thyrotropin as measured in a congenital hypothyroidism screening program: influence of the mode of delivery. J Clin Endocrinol Metab 2005;90: Lakshminarayana SG, Sadanandan NP, Mehaboob AK, Gopaliah LR. Effect of maternal and neonatal factors on cord blood thyroid stimulating hormone. Indian J Endocrinol Metab 2016;20: Armanian AM, Hashemipour M, Esnaashari A, Kelishadi R, Farajzadegan Z. Influence of perinatal factors on thyroid stimulating hormone level in cord blood. Adv Biomed Res 2013;2: Gupta A, Srivastava S, Bhatnagar A. Cord blood thyroid stimulating hormone level--interpretation in light of perinatal factors. Indian Pediatr 2014;51: Kang SY, Chang YP, Yu J. Reevaluation of the neonatal screening test for congenital hypothyroidism. Korean J Pediatr 2005;48: Haugen BR. Drugs that suppress TSH or cause central hypothyroidism. Best Pract Res Clin Endocrinol Metab 2009;23: Ersch J, Beinder E, Stallmach T, Bucher HU, Torresani T. 17-Hydroxyprogesterone in premature infants as a marker of intrauterine stress. J Perinat Med 2008;36: Fisher DA, Klein AH. Thyroid development and disorders of thyroid function in the newborn. N Engl J Med 1981; 304: Vandevijvere S, Coucke W, Vanderpas J, Trumpff C, Fauvart M, Meulemans A, et al. Neonatal thyroid-stimulating hormone concentrations in Belgium: a useful indicator for detecting mild iodine deficiency? PLoS One 2012;7:e Chung HR, Shin CH, Yang SW, Choi CW, Kim BI, Kim EK, et al. High incidence of thyroid dysfunction in preterm infants. J Korean Med Sci 2009;24: Raj S, Baburaj S, George J, Abraham B, Singh S. Cord blood TSH level variations in newborn - experience from a rural centre in Southern India. J Clin Diagn Res 2014;8:PC Lain SJ, Roberts CL, Wilcken B, Wiley V, Jack MM, Nassar N. Using record linkage to investigate perinatal factors and neonatal thyroid-stimulating hormone. J Paediatr Child Health 2015;51: Ng SM, Wong SC, Paize F, Chakkarapani E, Newland P, Isherwood D, et al. Multivariate analyses of factors that affect neonatal screening thyroid stimulating hormone. J Pediatr Endocrinol Metab 2011;24:
Perinatal variables influencing cord blood thyroid stimulating hormone
International Journal of Contemporary Pediatrics Garg MD et al. Int J Contemp Pediatr. 2018 Jul;5(4):1537-1541 http://www.ijpediatrics.com pissn 2349-3283 eissn 2349-3291 Original Research Article DOI:
More informationIntra-amniotic thyroxine to treat fetal goiter
Case Report Obstet Gynecol Sci 2016;59(1):66-70 http://dx.doi.org/10.5468/ogs.2016.59.1.66 pissn 2287-8572 eissn 2287-8580 Intra-amniotic thyroxine to treat fetal goiter Min-Jung Kim 1, Yong-Hwa Chae 2,
More informationInformation for health professionals
Changes to the Newborn Bloodspot Screening Policy for Congenital Hypothyroidism (CHT) in Preterm Babies A UK policy change has been agreed that will mean changes to: which preterm babies require second
More informationFACTORS INFLUENCING NEONATAL THYROID-STIMULATING HORMONE LEVEL IN NAKHON PATHOM PROVINCE, THAILAND
P-MS057 FACTORS INFLUENCING NEONATAL THYROID-STIMULATING HORMONE LEVEL IN NAKHON PATHOM PROVINCE, THAILAND Samart Punpetch 1, *, Kitipong Hancharean 2, # 1 Master of Science Program in Public Health (Infectious
More informationA descriptive study of the prevalence of hypothyroidism among antenatal women and foetal outcome in treated hypothyroid women
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Prasad DR et al. Int J Reprod Contracept Obstet Gynecol. 2016 Jun;5(6):1892-1896 www.ijrcog.org pissn 2320-1770 eissn 2320-1789
More informationRecall rate and incidence of congenital hypothyroidism: A 5-year experience of hospital-based study in Bahrain.
Curr Pediatr Res 2018; 22 (2): 137-142 ISSN 0971-9032 www.currentpediatrics.com Recall rate and incidence of congenital hypothyroidism: A 5-year experience of hospital-based study in Bahrain. Eman Shajira,
More informationLecture title. Name Family name Country
Lecture title Name Family name Country Nguyen Thy Khue, MD, PhD Department of Endocrinology HCMC University of Medicine and Pharmacy, MEDIC Clinic Hochiminh City, Viet Nam Provided no information regarding
More informationReliable. results. efficiently. for CH, galactosemia, CAH and CF screening
GSP Neonatal assays for CH, galactosemia, CAH and CF screening Reliable results efficiently GSP Neonatal kits DELFIA or enzyme-based fluorescence assays GSP is the new, automated neonatal screening system
More informationClinical efficacy of therapeutic intervention for subclinical hypothyroidism during pregnancy
Clinical efficacy of therapeutic intervention for subclinical hypothyroidism during pregnancy R. Ju 1, L. Lin 2, Y. Long 2, J. Zhang 2 and J. Huang 2 1 Gynaecology and Obstetrics Department, Beijing Chuiyangliu
More informationPrevalence of thyroid disorder in pregnancy and pregnancy outcome
Original Research Article Prevalence of thyroid disorder in pregnancy and pregnancy outcome Praveena K.R. 1, Pramod Kumar K.R. 2*, Prasuna K.R. 3, Krishna Kumar TV 4 1 Assistant Professor, Department of
More informationMFMU - Background. MFMU - Background MFMU GOALS
MFMU - Background Highlights From The MFM Units Network Ronald Wapner, MD Modern OB management (especially high risk pregnancies) has adopted principles of care, employed pharmaceuticals, applied methodologies
More informationCongenital Hypothyroidism Associated with Maternal Hypothyroidism and Iodine Deficiency During Pregnancy
CASE REPORT Congenital Hypothyroidism Associated with Maternal Hypothyroidism and Iodine Deficiency During Pregnancy Smita Kargutkar-Ajgaonkar Consultant Endocrinologist, Monmouth Medical Center, Long
More informationOvert and subclinical hypothyroidism among Bangladeshi pregnant women and its effect on fetomaternal outcome
Bangladesh Med Res Counc Bull 21; : 52-57 Overt and subclinical hypothyroidism among Bangladeshi pregnant women and its effect on fetomaternal outcome Sharmeen M, Shamsunnahar A, Laita TR, Chowdhury SB
More informationObjectives. Medical Complications of Pregnancy. Potential Conflicts: None. Common Complicating Medical Conditions that Precede Pregnancy
Medical Complications of Potential Conflicts: None Ellen W. Seely, M.D. Director of Clinical Research Endocrine-Hypertension Division Brigham and Women s Hospital Professor of Medicine Harvard Medical
More informationManagement of Pregestational and Gestational Diabetes Mellitus
Background and Prevalence Management of Pregestational and Gestational Diabetes Mellitus Pregestational Diabetes - 8 million women in the US are affected, complicating 1% of all pregnancies. Type II is
More informationStudy of renal functions in neonatal asphyxia
Original article: Study of renal functions in neonatal asphyxia *Dr. D.Y.Shrikhande, **Dr. Vivek Singh, **Dr. Amit Garg *Professor and Head, **Senior Resident Department of Pediatrics, Pravara Institute
More informationCord blood bilirubin used as an early predictor of hyperbilirubinemia
International Journal of Contemporary Pediatrics Ramamoorthy K et al. Int J Contemp Pediatr. 218 Jul;5(4):128-1285 http://www.ijpediatrics.com pissn 2349-3283 eissn 2349-3291 Original Research Article
More informationVishwanath Pattan Endocrinology Wyoming Medical Center
Vishwanath Pattan Endocrinology Wyoming Medical Center Disclosure Holdings in Tandem Non for this Training Introduction In the United States, 5 to 6 percent of pregnancies almost 250,000 women are affected
More informationDue to the importance of early detection for CH to
of ism Se Hospital K Lu r S 0 Sakinah, FRCP*, B A K Khalid, FRCP*, A Roslan*, A G Zainal*, M L Ng, PhD**, N Adeeb, FRCOG***, "Departments of Medicine, **Biochemistry and Obstetrics and ***Gynaecology,
More informationINFANT OF A MOTHER WITH GRAVES DISEASE. Endorama May 14 th, 2015 Carmen Mironovici, M.D.
INFANT OF A MOTHER WITH GRAVES DISEASE Endorama May 14 th, 2015 Carmen Mironovici, M.D. Chief Complaint Newborn born to a mother with autoimmune hyperthyroidism HPI Male infant born at 39w 2d gestation
More informationThe subjects were participants in a Dutch national prospective study, running from April
Supplemental Data Subjects The subjects were participants in a Dutch national prospective study, running from April 1, 1994 to April 1, 1996. Infants with neonatal screening results indicative of CH-C
More informationEsther Briganti. Fetal And Maternal Health Beyond the Womb: hot topics in endocrinology and pregnancy. Endocrinologist and Clinician Researcher
Fetal And Maternal Health Beyond the Womb: hot topics in endocrinology and pregnancy Esther Briganti Endocrinologist and Clinician Researcher Director, Melbourne Endocrine Associates Associate Professor,
More informationChecking the Right Box at the Right Age: the Art of Pediatric Endocrine Testing
Checking the Right Box at the Right Age: the Art of Pediatric Endocrine Testing Jean-Pierre Chanoine, MD Endocrinology and Diabetes Unit British Columbia s Children s Hospital Objectives 1. Interpret the
More informationMaternal and perinatal outcome in antenatal women with hypothyroidism
Original Research Article Maternal and perinatal outcome in antenatal women with hypothyroidism Polumuru Usha Devi 1, Gundu Vanaja 1* 1 Assistant Professor of Obstetrics and Gynecology, Andhra Medical
More informationDepartment of Pediatrics, Tokai University School of Medicine, Isehara, Kanagawa , Japan
Endocrine Journal 2003, 50 (4), 379 384 Persistence of Mild Hyperthyrotropinemia after Discontinuation of Three-Year Course of Low-Dose L-Thyroxine Therapy in Infants with Borderline Hypothyroidism YUICHIRO
More informationWhat Has National Screening Program Changed in Cases with Congenital Hypothyroidism?
Original Article Iran J Pediatr Jun 2014; Vol 24 (No 3), Pp: 255-260 What Has National Screening Program Changed in Cases with Congenital Hypothyroidism? Şebnem Özgelen, MD; Veysel Nijat Baş*, MD; Semra
More informationMorbidity profile of infants of mothers with gestational diabetes admitted to a tertiary care centre
International Journal of Contemporary Pediatrics Devi Meenakshi K. BB et al. Int J Contemp Pediatr. 2017 May;4(3):960-965 http://www.ijpediatrics.com pissn 2349-3283 eissn 2349-3291 Original Research Article
More informationN. Rajya Lakshmi et al : Early Clinical Exposure. Abdominal circumference its relation to blood lipid levels in new born.
Original Article N. Rajya Lakshmi et al : Early Clinical Exposure Abdominal circumference its relation to blood lipid levels in new born. Sreelatha M 1, *M.Dasardharami Reddy M 2, Padma Mohan P 3, Jain
More informationDR.RUPNATHJI( DR.RUPAK NATH )
45. Screening for Congenital Hypothyroidism Burden of Suffering In the U.S., congenital hypothyroidism occurs in 1 of 3,600 4,000 infants. 1,2 Clinical diagnosis occurs in
More informationEffect of Various Degrees of Maternal Hyperglycemia on Fetal Outcome
ORIGINAL ARTICLE Effect of Various Degrees of Maternal Hyperglycemia on Fetal Outcome ABSTRACT Shagufta Tahir, Shaheen Zafar, Savita Thontia Objective Study design Place & Duration of study Methodology
More informationCongenital hypothyroidism screening program in Turkey: a local evaluation
The Turkish Journal of Pediatrics 2012; 54: 590-595 Original Congenital hypothyroidism screening program in Turkey: a local evaluation Yusuf Kuşdal, Gül Yeşiltepe-Mutlu, Elif Özsu, Filiz Mine Çizmecioğlu,
More informationPrediction of congenital hypothyroidism based on initial screening thyroidstimulating-hormone
Saleh et al. BMC Pediatrics (2016) 16:24 DOI 10.1186/s12887-016-0559-0 RESEARCH ARTICLE Open Access Prediction of congenital hypothyroidism based on initial screening thyroidstimulating-hormone David S.
More informationClinicoetiological profile and risk assessment of newborn with respiratory distress in a tertiary care centre in South India
International Journal of Contemporary Pediatrics Sahoo MR et al. Int J Contemp Pediatr. 2015 Nov;2(4):433-439 http://www.ijpediatrics.com pissn 2349-3283 eissn 2349-3291 Research Article DOI: http://dx.doi.org/10.18203/2349-3291.ijcp20150990
More informationA study of neonatal and maternal outcomes of asthma during pregnancy
International Journal of Research in Medical Sciences Meena BL et al. Int J Res Med Sci. 2013 Feb;1(1):23-27 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Research Article DOI: 10.5455/2320-6012.ijrms20130206
More informationCongenital Hypothyroidism is the most
R E S E A R C H P A P E R Cord Blood Thyroid Stimulating Hormone Level Interpretation in Light of Perinatal Factors AMIT GUPTA, SMITA SRIVASTAVA AND ANJOO BHATNAGAR From Department of Pediatrics and Neonatology,
More informationThyrotoxicosis in Pregnancy: Diagnose and Management
Thyrotoxicosis in Pregnancy: Diagnose and Management Yuanita Asri Langi email: meralday@yahoo.co.id Endocrinology & Metabolic Division, Internal Medicine Department, Prof.dr.R.D. Kandou Hospital/ Sam Ratulangi
More informationClinical Guideline MANAGEMENT OF INFANTS BORN TO MOTHERS WITH GRAVES DISEASE AND AT RISK OF THYROTOXICOSIS
Clinical Guideline MANAGEMENT OF INFANTS BORN TO MOTHERS WITH GRAVES DISEASE AND AT RISK OF THYROTOXICOSIS Date of First Issue 18/07/2016 Approved 28/09/2017 Current Issue Date 16/06/2017 Review Date 01/09/2019
More informationNEWBORN FEMALE WITH GOITER PAYAL PATEL, M.D. PEDIATRIC ENDOCRINOLOGY FELLOW FEBRUARY 12, 2015
NEWBORN FEMALE WITH GOITER PAYAL PATEL, M.D. PEDIATRIC ENDOCRINOLOGY FELLOW FEBRUARY 12, 2015 CHIEF COMPLAINT 35 6/7 week F with goiter, born to a mother with Graves disease (GD) HPI 35 6/7 week F born
More informationDoes Congenital Hypothyroidism Have Different Etiologies in Iran?
Original Article Iran J Pediatr Jun 2011; Vol 21 (No 2), Pp: 188-192 Does Congenital Hypothyroidism Have Different Etiologies in Iran? Zohre Karamizadeh 1, MD; Setillia Dalili 1, MD; Heidyeh Sanei-far
More informationPregnancy outcomes in Korean women with diabetes
Pregnancy outcomes in Korean women with diabetes Sung-Hoon Kim Department of Medicine, Cheil General Hospital & Women s Healthcare Center, Dankook University College of Medicine, Seoul, Korea Conflict
More informationHow to manage hypothyroid disease in pregnancy
For mass reproduction, content licensing and permissions contact Dowden Health Media. FIRST OF 2 PARTS How to manage hypothyroid disease in pregnancy Pregnancy complicated by hypothyroidism puts mother
More informationResearch Article Mean Platelet Volume Reflect Hematopoietic Potency and Correlated Blood Group O in Cord Blood from Healthy Newborn
BioMed Volume 2013, Article ID 754169, 4 pages http://dx.doi.org/10.1155/2013/754169 Research Article Mean Platelet Volume Reflect Hematopoietic Potency and Correlated Blood Group O in Cord Blood from
More informationPrevalence of Sarcopenia Adjusted Body Mass Index in the Korean Woman Based on the Korean National Health and Nutritional Examination Surveys
J Bone Metab 2016;23:243-247 https://doi.org/10.11005/jbm.2016.23.4.243 pissn 2287-6375 eissn 2287-7029 Original Article Prevalence of Sarcopenia Adjusted Body Mass Index in the Korean Woman Based on the
More informationThe Diabetes Epidemic in Korea
Review Article Endocrinol Metab 2016;31:349-33 http://dx.doi.org/.3803/enm.2016.31.3.349 pissn 2093-96X eissn 2093-978 The Diabetes Epidemic in Korea Junghyun Noh Department of Internal Medicine, Inje
More informationResearch Roundtable Summary
Research Roundtable Summary 10 TENTH in a Series of Seminars on MCHB-funded Research Projects Early Cortisol Deficiency and Bronchopulmonary Dysplasia October 18, 1995 Parklawn Building Potomac Conference
More informationComparative Study between Acarbose and Insulin in the Treatment of GDM.
Original Article DOI: 10.21276/aimdr.2018.4.2.OG5 ISSN (O):2395-2822; ISSN (P):2395-2814 Comparative Study between Acarbose and Insulin in the Treatment of GDM. Minthami Sharon 1, Niloufur Syed Bashutheen
More informationCongenital Hypothyroidism in the Southern Bangladesh
TAJ June 2008; Volume 21 Number 1 ISSN 1019-8555 The Journal of Teachers Association RMC, Rajshahi Original Article Congenital Hypothyroidism in the Southern Bangladesh C Habibur Rasul 1, S Nahar Lucky
More informationEVALUATION OF THYROID FUNCTION IN PRE-ECLAMPSIA
EVALUATION OF THYROID FUNCTION IN PRE-ECLAMPSIA K. Sunanda 1, P. Sravanthi 2, H. Anupama 3 1Assistant Professor, Department of Obstetrics & Gynaecology, Gandhi Medical College/Hospital. 2Post Graduate,
More informationClinical Study Risk-Based Screening for Thyroid Dysfunction during Pregnancy
Pregnancy Volume 2013, Article ID 619718, 5 pages http://dx.doi.org/10.1155/2013/619718 Clinical Study Risk-Based Screening for Thyroid Dysfunction during Pregnancy Masanao Ohashi, 1 Seishi Furukawa, 2
More informationPrevention and Management of Diabetes in Pregnancy
Prevention and Management of Diabetes in Pregnancy Sridhar Chitturi Consultant Endocrinologist Royal Darwin Hospital Outline of the talk Diabetes in Pregnancy Spectrum Diagnostic criteria Why bother about
More informationCorrelation of Neurodevelopmental Outcome and brain MRI/EEG findings in term HIE infants
Correlation of Neurodevelopmental Outcome and brain MRI/EEG findings in term HIE infants Ajou University School of Medicine Department of Pediatrics Moon Sung Park M.D. Hee Cheol Jo, M.D., Jang Hoon Lee,
More informationLow T 4, Normal TSH. Normal T 4, High TSH. Normal TSH Preterm 2(6.67%) 7(23.33%)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 16, Issue 7 Ver. VIII (July. 2017), PP 58-62 www.iosrjournals.org A Cross Sectional Study of Thyroid
More informationAnnual Report on the External Quality Assessment Scheme for Biochemical Genetics in Korea (2014)
ANNUAL REPORT http://dx.doi.org/10.15263/jlmqa.2015.37.2.56 Annual Report on the External Quality Assessment Scheme for Biochemical Genetics in Korea (2014) Soo-Youn Lee 1, Ok Ja Ji 1, Gye Cheol Kwon 2,
More informationAdmission/Discharge Form for Infants Born in Please DO NOT mail or fax this form to the CPQCC Data Center. This form is for internal use ONLY.
Selection Criteria Admission/Discharge Form for Infants Born in 2016 To be eligible, you MUST answer YES to at least one of the possible criteria (A-C) A. 401 1500 grams o Yes B. GA range 22 0/7 31 6/7
More informationInfant Of Diabetic Mother(IDM)
Infant Of Diabetic Mother(IDM) Sangram Satish Magar 1, Sanskriti Mirashi 2 1. M.D. Sch.(Kaumarbhrutya-Balrog) 2.Guide (Kaumarbhrutya-Balrog), L.R.P.Medical college,islampur,tal- Walwa, dist- Sangli, Maharashtra,
More informationPedsCases Podcast Scripts
PedsCases Podcast Scripts This is a text version of a podcast from Pedscases.com on the Approach to Pediatric Anemia and Pallor. These podcasts are designed to give medical students an overview of key
More informationThe Controversy on Mild (Compensated) Congenital Hypothyroidism The Path We Took to Resolve the Dilemma in Washington Newborn Screening
The Controversy on Mild (Compensated) Congenital Hypothyroidism The Path We Took to Resolve the Dilemma in Washington Newborn Screening Caroline T. Nucup-Villaruz, MD Primary Author Washington State DOH
More informationLow concentrations of maternal thyroxin during early gestation: a risk factor of breech presentation?
BJOG: an International Journal of Obstetrics and Gynaecology September 2004, Vol. 111, pp. 925 930 DOI: 10.1111/j.1471-0528.2004.00213.x Low concentrations of maternal thyroxin during early gestation:
More informationNeonatal Hypoglycemia. Presented By : Kamlah Olaimat 25\7\2010
Neonatal Hypoglycemia Presented By : Kamlah Olaimat 25\7\2010 Definition The S.T.A.B.L.E. Program defines hypoglycemia as: Glucose delivery or availability is inadequate to meet glucose demand (Karlsen,
More informationASSOCIATIONS BETWEEN THYROID DYSFUNCTION AND CHRONIC KIDNEY DISEASE
2014 ILEX PUBLISHING HOUSE, Bucharest, Roumania http://www.jrdiabet.ro Rom J Diabetes Nutr Metab Dis. 21(1):37-42 doi: 10.2478/rjdnmd-2014-0006 ASSOCIATIONS BETWEEN THYROID DYSFUNCTION AND CHRONIC KIDNEY
More informationThyroid disorders in antenatal women in a rural hospital in central India
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Mahajan KS et al. Int J Reprod Contracept Obstet Gynecol. 2016 Jan;5(1):62-67 www.ijrcog.org pissn 2320-1770 eissn 2320-1789
More informationDiagnosis of gestational diabetes mellitus: comparison between National Diabetes Data Group and Carpenter Coustan criteria
Asian Biomedicine Vol. 8 No. 4 August 2014; 505-509 Brief communication (Original) DOI: 10.5372/1905-7415.0804.320 Diagnosis of gestational diabetes mellitus: comparison between National Diabetes Data
More informationDiabetes in Pregnancy
Diabetes in Pregnancy Resident School November 5 2014 Goals Be able to screen for gestational and preexisting diabetes Be able to counsel women on the diagnosis of gestational diabetes Understand glucose
More information344 Thyroid Disorders
344 Thyroid Disorders Definition/Cut-Off Value Thyroid dysfunctions that occur in pregnant and postpartum women, during fetal development, and in childhood are caused by the abnormal secretion of thyroid
More informationA S Y N T H E S I Z E D H A N D B O O K ON G E S T A T I O N A L D I A B E T E S
A S Y N T H E S I Z E D H A N D B O O K ON G E S T A T I O N A L D I A B E T E S P R E F A C E Dear reader, This is a synthesized handbook conceived to serve as a tool to health personnel in the screening,
More informationStudy of thyroid profile during pregnancy
Original Research Article Study of thyroid profile during pregnancy Raghav Nepalia 1*, Renuka Z Lal 2 1 Sr. Demonstrator, 2 Assistant Professor Department of Biochemistry, RNT Medical College, Udaipur,
More informationThe Thyroid and Pregnancy OUTLINE OF DISCUSSION 3/19/10. Francis S. Greenspan March 19, Normal Physiology. 2.
The Thyroid and Pregnancy Francis S. Greenspan March 19, 2010 OUTLINE OF DISCUSSION 1. Normal Physiology 2. Hypothyroidism 3. Hyperthyroidism 4. Thyroid Nodules and Cancer NORMAL PHYSIOLOGY Iodine Requirements:
More information2018 Standard of Medical Care Diabetes and Pregnancy
2018 Standard of Medical Care Diabetes and Pregnancy 2018 Standard of Medical Care Diabetes and Pregnancy Marjorie Cypress does not have any relevant financial relationships with any commercial interests
More informationCongenital hypothyroidism and your child
Congenital hypothyroidism and your child Contributed by Sirisha Kusuma. B Consultant Pediatric Endocrinologist Rainbow Children s hospital What is Thyroid? The thyroid is a small butterfly shaped endocrine
More informationLaura Stewart, MD, FRCPC Clinical Associate Professor Division of Pediatric Endocrinology University of British Columbia
Precocious Puberty Laura Stewart, MD, FRCPC Clinical Associate Professor Division of Pediatric Endocrinology University of British Columbia Faculty Disclosure Faculty: Laura Stewart No relationships with
More informationOriginal Article
Original Article Endocrinol Metab 2018;33:395-402 https://doi.org/10.3803/enm.2018.33.3.395 pissn 2093-596X eissn 2093-5978 Effects of Maternal Iodine Status during Pregnancy and Lactation on Maternal
More informationMonitoring and prognostic evaluation of patients with congenital hypothyroidism treated in a pediatric endocrinology unit
The Turkish Journal of Pediatrics 2013; 55: 384-390 Original Monitoring and prognostic evaluation of patients with congenital hypothyroidism treated in a pediatric endocrinology unit Tolga Ünüvar 1, Korcan
More informationA randomised controlled trial of iodine supplementation in extreme preterm infants
A randomised controlled trial of iodine supplementation in extreme preterm infants Content Introduction o What is transient hypothyroxinaemia? o Why is this important? o Causes of transient hypothyroxinaemia
More informationDiabetes in Pregnancy. L.Sekhavat MD
Diabetes in Pregnancy L.Sekhavat MD Diabetes in Pregnancy Gestational Diabetes Pre-gestational diabetes (overt) Insulin dependent (type1) Non-insulin dependent (type 2) Definition Gestational diabetes
More informationA Study of relationship between frailty and physical performance in elderly women
Original Article Journal of Exercise Rehabilitation 2015;11(4):215-219 A Study of relationship between frailty and physical performance in elderly women Bog Ja Jeoung 1, *, Yang Chool Lee 2 1 Department
More informationThe New GDM Screening Guidelines. Jennifer Klinke MD, FRCPC Endocrinologist and Co director RCH Diabetes in Pregnancy Program
The New GDM Screening Guidelines Jennifer Klinke MD, FRCPC Endocrinologist and Co director RCH Diabetes in Pregnancy Program Disclosures Current participant (RCH site) for MiTy study Metformin in women
More informationThe high risk neonate
The high risk neonate Infant classification by gestational (postmenstrual) age Preterm. Less than 37 completed weeks (259 days). Term. Thirty-seven to 416/7 weeks (260-294 days). Post-term. Forty-two weeks
More informationRelation between the Peripherofacial Psoriasis and Scalp Psoriasis
pissn 1013-9087ㆍeISSN 2005-3894 Ann Dermatol Vol. 28, No. 4, 2016 http://dx.doi.org/10.5021/ad.2016.28.4.422 ORIGINAL ARTICLE Relation between the Peripherofacial Psoriasis and Scalp Psoriasis Kyung Ho
More informationEffect of Gestational Diabetes mellitus Health Education Module on Pregnancy Outcomes
World Journal of Nursing Sciences 1 (3): 76-88, 2015 ISSN 2222-1352 IDOSI Publications, 2015 DOI: 10.5829/idosi.wjns.2015.76.88 Effect of Gestational Diabetes mellitus Health Education Module on Pregnancy
More informationUsefulness of Ultrasonography in Diagnosing Congenital Adrenal Hyperplasia in Neonates
Clin Pediatr Endocrinol 1993;2(2):99-105 Copyright (C)1993 by The Japanese Society for Pediatric Endocrinology Usefulness of Ultrasonography in Diagnosing Congenital Adrenal Hyperplasia in Neonates Kunio
More informationNeonatal Thyrotoxicosis Management of babies born to mothers with a history of hyperthyroidism (Grave s Disease)
MCN for Neonatology West of Scotland Neonatal Guideline Neonatal Thyrotoxicosis Management of babies born to mothers with a history of hyperthyroidism (Grave s Disease) This document is applicable to all
More informationDiagnosing Growth Disorders. PE Clayton School of Medical Sciences, Faculty of Biology, Medicine & Health
Diagnosing Growth Disorders PE Clayton School of Medical Sciences, Faculty of Biology, Medicine & Health Content Normal pattern of growth and its variation Using growth charts Interpreting auxological
More informationHYPOTHYROIDISM IN CHILDREN. IAP UG Teaching slides
HYPOTHYROIDISM IN CHILDREN 1 OBJECTIVES Introduction Congenital hypothyroidism Etiology, clinical features, diagnosis, approach, treatment and prognosis Acquired hypothyroidism Etiology, clinical features,
More informationUpdate on Gestational Thyroid Disease. Aidan McElduff The Discipline of Medicine, The University of Sydney
IADPSG 2016 Update on Gestational Thyroid Disease Aidan McElduff The Discipline of Medicine, The University of Sydney IADPSG 2016 DISCLOSURES and AIM Nil to disclose Aim: to provide an overview 2017 Guidelines
More informationBELIEVE MIDWIFERY SERVICES
TITLE: THYROID DISEASE IN PREGNANCY EFFECTIVE DATE: July, 2013 POLICY STATEMENT: Pregnancy changes significantly the values influenced by the serum thyroid binding hormone level (i.e., total thyroxine,
More informationLabor & Delivery Management for Women Living with HIV. Pooja Mittal, DO Lisa Rahangdale, MD
Labor & Delivery Management for Women Living with HIV Pooja Mittal, DO Lisa Rahangdale, MD Statistics for Perinatally Acquired HIV Timing of Perinatal HIV Transmission Most transmission occurs close to
More informationCOMPLICATIONS OF PRE-GESTATIONAL AND GESTATIONAL DIABETES IN SAUDI WOMEN: ANALYSIS FROM RIYADH MOTHER AND BABY COHORT STUDY (RAHMA)
COMPLICATIONS OF PRE-GESTATIONAL AND GESTATIONAL DIABETES IN SAUDI WOMEN: ANALYSIS FROM RIYADH MOTHER AND BABY COHORT STUDY (RAHMA) Prof. Hayfaa Wahabi, King Saud University, Riyadh Saudi Arabia Hayfaa
More informationPart I Initial Office Visit. Questions NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE
Thyroid Troubles: A Case Study in Negative Feedback Regulation by Breanna N. Harris Department of Biological Sciences Texas Tech University, Lubbock, TX Part I Initial Office Visit You are six months into
More informationMin Hur, Eun-Hee Kim, In-Kyung Song, Ji-Hyun Lee, Hee-Soo Kim, and Jin Tae Kim INTRODUCTION. Clinical Research
Anesth Pain Med 2016; 11: 375-379 https://doi.org/10.17085/apm.2016.11.4.375 Clinical Research http://crossmark.crossref.org/dialog/?doi=10.17085/apm.2016.11.4.375&domain=pdf&date_stamp=2016-10-25 pissn
More informationStandardized Thyroid Cancer Mortality in Korea between 1985 and 2010
Original Article Endocrinol Metab 2014;29:530-535 http://dx.doi.org/10.3803/enm.2014.29.4.530 pissn 2093-596X eissn 2093-5978 Standardized Thyroid Cancer Mortality in Korea between 1985 and 2010 Yun Mi
More informationPregestational and Gestational Diabetes
Pregestational and Gestational Diabetes Francis S. Nuthalapaty, MD Greenville Health System University of South Carolina School of Medicine - Greenville Case History 30 year old black female presents to
More informationResistance to Thyroid Hormone and Down Syndrome: Coincidental Association or. Genetic Linkage?
Page 1 of 6 1 Resistance to Hormone and Down Syndrome: Coincidental Association or Genetic Linkage? (doi: 10.1089/thy.2011-0316) Resistance to Hormone and Down Syndrome: Coincidental Association or Genetic
More informationPediatric Endocrine Society and Endocrine Society. Treatment of Primary Congenital Hypothyroidism
Pediatric Endocrine Society and Endocrine Society Treatment of Primary Approved September 2014 Pediatric Endocrine Society 6728 Old McLean Village Drive McLean, VA 22101 (P) 703-556-9222 (F) 703-556-8729
More informationStatistical characteristics of anterior fontanelle size at birth of term Sri Lankan new borns: a descriptive cross sectional study
Statistical characteristics of anterior fontanelle size at birth of term Sri Lankan new borns: a descriptive cross sectional study P J Perera 1, A R Wickramasinghe 2, N Ranathunga 3, M P Fernanado 1, D
More informationDepartment of Paediatric Endocrinology, Royal Manchester Children s Hospital,
Title: RETROSPECTIVE REVIEW OF SYNACTHEN TESTING IN INFANTS Authors: Timothy Shao Ern Tan 1*, Claire Manfredonia 2*, Rakesh Kumar 1, Julie Jones 1, Elaine O Shea 1, Raja Padidela 1, Mars Skae 1, Sarah
More informationPaul Hofman. Professor. Paediatrician Endocrinologist Liggins Institute, The University of Auckland, Starship Children Hospital, Auckland
Professor Paul Hofman Paediatrician Endocrinologist Liggins Institute, The University of Auckland, Starship Children Hospital, Auckland 9:25-9:50 Endocrine and Metabolic Consequences of Being Born Preterm
More informationAge at menarche and adult height in girls born small for gestational age
Original article http://d.doi.org/.665/apem.3.8..76 Ann Pediatr Endocrinol Metab 3;8:76-8 Age at menarche and adult height in girls born small for gestational age Young Suk Shim, MD, Hong Kyu Park, MD,
More informationGestational Diabetes Mellitus Dr. Fawaz Amin Saad
Gestational Diabetes Mellitus Dr. Fawaz Amin Saad Senior Consultant OB/GYN, Al-Hayat Medical Center, Doha, Qatar DISCLOSURE OF CONFLICT OF INTEREST I am a full-time Employee at Al-Hayat Medical Center.
More informationClinical and Laboratory Characteristics of Childhood Diabetes Mellitus: A Single-Center Study from 2000 to 2013
Original Article www.cmj.ac.kr Clinical and Laboratory Characteristics of Childhood Diabetes Mellitus: A Single-Center Study from 2000 to 2013 Tae Hyun Park 1, Min Sun Kim 1,2, * and Dae-Yeol Lee 1,2 1
More informationGestational Diabetes: An Update on Testing. Kimberlee A McKay, M.D. Avera Medical Group Ob/GYN
Gestational Diabetes: An Update on Testing Kimberlee A McKay, M.D. Avera Medical Group Ob/GYN Gestational Diabetes Increased risks of: Still Birth Hydramnios Should Dystocia Prolonged Labor Preeclampsia
More information