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1 Table 1: Effective Dose Equivalent (HE) values for common procedures involving the use of radiopharmaceuticals. Listings (last column) are averaged over both sexes, and are computed for adult subjects. Values are not necessarily appropriate for pediatric subjects. Instructions for the use of the table are listed below. Nuclide Chemical Form Route of Admin. Condition HE mrem/mci 3 H Water Any H Inulin IV Normal renal function H Inulin IV Abnormal renal function H Glucose IV Normal 8.29 arbon Monoxide Inhalation Single inhalation with 20 s breathhold 24.4 C arbon Monoxide Inhalation Continuous inhalation for 1 h 15.9 C arbon Dioxide Inhalation Single inhalation with 20 s breathhold 6.29 C arbon Dioxide Inhalation Continuous inhalation for 1 h 4.07 C Carfentanil IV 17.5 COHb-Labelled Erythrocytes IV 25.5 Doxepin IV 30.2 Methyl Spiperone IV 30.0 Pyrilamine IV 36.4 PK IV 32.6 Raclopride IV 66.0 RO (Flumazenil) IV 9.96 SCH23390 IV 51.2 Thymidine IV 10.0 WIN IV C Inulin IV Normal renal function C Inulin IV Abnormal renal function N Ammonia IV O Carbon Monoxide Inhalation Single inhalation with 20 s breathhold 4.07 (REVISED 7/96) 1

2 15 O Carbon Monoxide Inhalation Continuous inhalation for 1h Carbon Dioxide Inhalation Single inhalation with 20 s breathhold 2.00 O 15 O Carbon Dioxide Inhalation Continuous inhalation for 1 h Oxygen Gas Inhalation Single inhalation with 20 s breathhold 1.44 O 15 O Oxygen Gas Inhalation Continuous inhalation for 1 h O Water IV F Fluoride ion IV F 2-Fluoro-2-Deoxy-D-Glucose (FDG) IV Na, Sodium ion IV or Oral Na Sodium ion IV Na Sodium ion Oral m Cl Chloride ion IV or Oral Cl Chloride ion IV or Oral Cl Chloride ion IV or Oral K Potassium ion IV 99.9 (REVISED 7/96) 2

3 Nuclide Chemical Form Route of Condition Admin. HE mrem/mci 42 K Potassium ion IV K Potassium ion Oral K Potassium ion IV K Potassium ion Oral Ca Calcium ion IV Ca Calcium ion Oral Ca Calcium ion IV Ca Calcium ion Oral Cr Chromium-Labelled Erythrocytes IV Ga Gallium Citrate IV Ga Gallium Citrate IV Ga Gallium Citrate IV Ga Gallium Citrate IV m Krypton Inhalation, 0.1 Kr IV 82 Rb Rubidium ion IV Sr Strontium ion IV m Sr Strontium ion IV Sr Strontium ion IV Ceretec IV 37.3 Neurolite IV 28.8 Teboroxime IV 38.3 Technetium-Labelled Albumin (HSA) IV 29.2 Technetium-Labelled Albumin Intrathecal Lumbar injection 40.7 Technetium-Labelled Albumin Intrathecal Cisternal injection 25.2 Technetium-Labelled Large Colloids ( nm) IV Normal Liver function 51.8 (REVISED 7/96) 3

4 Labelled Small Colloids (<100 nm) IV Normal Liver function 51.8 Technetium-DMSA IV 59.2 Technetium-DTPA IV Normal renal function 23.3 Technetium-DTPA IV Abnormal renal function 19.6 Technetium-DTPA Intrathecal Lumbar injection 40.7 Technetium-DTPA Intrathecal Cisternal injection 24.4 Gluconate, Glucoheptonate IV 33.3 Pertechnetate ion IV No blocking agent 48.1 Pertechnetate ion IV Blocking agent given 19.6 Pertechnetate ion Oral No blocking agent Labelled Iminodiacetic Acid (IDA) IV Normal liver function 88.8 Derivatives -Labelled Iminodiacetic Acid (IDA) IV Parenchymal Liver Disease 48.1 Derivatives -Labelled Iminodiacetic Acid (IDA) IV Occlusion of the cystic duct 66.6 Derivatives -Labelled Iminodiacetic Acid (IDA) IV Occlusion of the common bile duct 35.5 Derivatives Technetium-Labelled Erythrocytes IV 31.5 (REVISED 7/96) 4

5 Nuclide Chemical Form Route of Condition Admin. HE mrem/mci -Labelled Phosphates and IV 29.6 Phosphonates labelled Sestamibi IV Labelled Aerosols Inhalation Substances with fast lung clearance Labelled Aerosols Inhalation Substance with slow lung clearance Labelled Non-Absorbable Markers Oral Fluid form Labelled Non-Absorbable Markers Oral Solid form Labelled Albumin Microspheres IV 40.7 Indium ion IV In Indium ion IV 48.1 Indium-DTPA IV Normal renal function 92.5 Indium-DTPA IV Abnormal renal function In Indium-DTPA IV Normal renal function In Indium-DTPA IV Abnormal renal function In Indium Hydroxide (Colloidal) IV Normal liver function Indium Hydroxide (Colloidal) IV Early to intermed. diffuse 70.3 In parenchymal liver disease 113 Indium Hydroxide (Colloidal) IV Intermed. to advanced diffuse 88.8 In parenchymal disease In-DTPA Intrathecal Lumbar injection 518 In-DTPA Intrathecal Cisternal injection 444 dium-labelled Platelets IV 2590 In (thrombocytes) -Labelled White Blood Cells IV 2180 In (Leukocytes) Indium antimyosin antibody IV 990 Iodide ion IV, Oral Thyroid blocked, uptake 0% 48.1 Iodide ion IV, Oral Thyroid uptake 55% I Iodide ion IV, Oral Thyroid blocked, uptake 0% I Iodide ion IV, Oral Thyroid uptake 55% I Iodide ion IV, Oral Thyroid blocked, uptake 0% 44.4 (REVISED 7/96) 5

6 125 I Iodide ion IV, Oral Thyroid uptake 55% Iodide ion IV, Oral Thyroid blocked, uptake 0% 266 Hippuran IV Normal renal function I Hippuran IV Normal renal function 37 Hippuran IV Normal renal function 244 Iodide ion IV, Oral Thyroid uptake 55% Iodine-Labelled Amphetamine IV 118 Iodine-Labelled Albumin (HSA) IV I Iodine-Labelled Albumin (HSA) IV 1260 Iodine-Labelled Albumin (HSA) IV 3182 Metaiodobenzylguanidine (MIB) IV 66.6 Metaiodobenzylguanidine (MIB) IV 740 Dexetimide IV 59.2 RTI-55 IV (REVISED 7/96) 6

7 Nuclide Chemical Form Route of Condition Admin. HE mrem/mci 127 non IV, Single inhalation or IV inj., with 0.52 Inhalation 30 s breath-hold 127 non IV, Rebreathing for 5 minutes 2.85 Inhalation 127 non IV, Rebreathing for 10 minutes 4.44 Inhalation 133 non IV, Single inhalation or i.v. inj., with 0.70 Inhalation 30 s breath-hold 133 non IV, Rebreathing for 5 minutes 2.96 Inhalation 133 non IV, Rebreathing for 10 minutes 4.81 Inhalation 201 Thallium ion IV 851 TI Instructions: For a given radiopharmaceutical procedure, select the table value corresponding to the nuclide and the route of administration. In some cases, particular conditions related to pathology or other variables are listed which will influence the dose to the subject. Use the dose for the particular condition (column 4) where appropriate. To compute the effective dose equivalent, multiply the table value by the activity administered in millicuries (mci). Effective dose equivalent values may be summed from different radiological procedures. (REVISED 7/96) 7

8 Table 2: Effective Dose Equivalent (H E ) values common radiographic procedures on adult subjects, assuming a beam filtration of 3.0 mm aluminum 1. For a given x-ray procedure, sum the table value for HE, for each repetition of each projection used. (Skin doses are provided for reference only, do not sum skin doses.) PROJECTION kvp SKIN DOSE (mrem) HE (mrem)* Skull AP Skull PA Skull Lateral C-Spine AP C-Spine Lateral Shoulder AP, Oblique Chest AP Chest PA Chest Lateral T-Spine AP T-Spine Lateral Kidneys AP Kidneys PA Abdomen AP Abdomen PA L-Spine AP L-Spine Oblique L-Spine Lateral L-S Joint Lateral Pelvis AP Hip(one) AP Urinary Bladder AP Table 3: Effective Dose Equivalent (HE) values for CT Scanners used on adult subjects. Values are expressed in mrem, normalized to 100 mas with abutted slices at the widest slice setting for adult subjects. See below). Siemens Siemens GE 9800 Scan Type 125 kv 120 kv 137 kv 80 kv 120 kv 140 KV Head Neck Chest Upper Abdomen Complete Abdomen Pelvis, Hips Jones, D.J & Wall, B.F: "Organ Doses from Medical X-ray Examinations Calculated Using Monte Carlo Techniques", National Radiological Protection Board, 1985, NRPB - R186 (HMSO, London). (REVISED 7/96) 8

9 Instructions for CT HE: For a given CT procedure, the mas, kvp, slice width and slice spacing must be known. (Available from the CT technologist). Select the value from Table 3 for the particular scanner, kvp setting and scan type. Use the following formula to calculate HE: HE = V x x where: V is the table value for the CT system and kvp, T and I are the slice width and slice spacing, respectively in mm. For example, a head scan with the Siemens DR3, using 125 kvp, 450 mas, slice width of 8 mm and slice spacin of 8 mm, the table value is 32 mrem/100 mas. The HE is then: HE = 32 x x = 144 mrem (REVISED 7/96) 9

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