Neuroendocrine Carcinoma. Lebanon Neuroendocrine Neoplasms of H&N Nov /7/2011. Broad Classification:
|
|
- Stephany Gardner
- 6 years ago
- Views:
Transcription
1 H&N Neuroendocrine Neoplasms: Classification and Diagnostic Considerations Adel K. El-Naggar, M.D., Ph.D. The University of Texas MD Anderson Cancer Center, Houston, Texas Broad Classification: A. Epithelial: Neuroendocrine carcinoma (Typical and atypical carcinoid and PDC) Medullary thyroid carcinoma Parathyroid tumors B. Non-Epithelial: Neuroblastoma Paraganglioma Neuroendocrine Carcinoma 1
2 Incidence: <1% of H&N tumors Etiology: Unknown!! Radiation Smoking Histogenesis Neuro-endocrine cell Undifferentiated / basal / stem cell Locations: Larynx Salivary glands (major and minor) Sino-nasal region Middle ear and endolymphatic sac 2
3 Larynx 3
4 Histologic Classification: Well differentiated (typical carcinoid) Moderately differentiated (atypical carcinoid) Poorly differentiated (small, large cell) Typical Carcinoid 4
5 Atypical Carcinoid 5
6 6
7 CAM 5.2 CK5/6 CD56 7
8 Poorly Differentiated Keratin 8
9 Synaptophysin Immuno Markers: Epithelial: Differentiated Undifferentiated Pan cytokeratin (AE1/AE3) ++ + EMA + +/- CK 5/ Neuroendocrine: Chromogranin Synaptophysin Calcitonin ++ - CD Management of Laryngeal NET: Differentiated: surgery Poorly differentiated: chemo + XRT 9
10 Clinical Characteristics of MD-NEC at MD Anderson Differential Diagnosis: A. Differentiated: Medullary thyroid carcinoma Paraganglioma Basaloid salivary adenocarcinoma RCC B. Undifferentiated: Small round cell tumors Undifferentiated carcinoma Basaloid squamous carcinoma Merkel Cell Carcinoma Case Presentation: 42 year old female With left neck mass (4.0 cm) Serum calcitonin: high Excision of neck mass 10
11 11
12 Diagnosis: Neuroendocrine carcinoma favor metastatic MTC Follow-up: Thyroid examination normal Hx of polypoid laryngeal nodule 5 years 12
13 Chromogranin 13
14 Calcitonin Comparative IHC of Laryngeal Primary and Lymph Node Metastasis: Marker Primary L-N Somatostatin - - Serotonin ++ + ACTH - - NSE Chromogranin CEA ++ + Calcitonin Diagnosis: MTC-like carcinoid tumor of the Larynx 14
15 Salivary Glands Primary: rare Differentiated tumors: rare Secondary: more common 15
16 Keratin Chromogranin 16
17 Differential Diagnosis: Merkel cell Ca Melanoma Metastatic, NEC RMS Primary: Surgery ± Chemotherapy/XRT Managment Secondary: Chemotherapy/XRT Middle Ear and Mastoid Neoplasms: 17
18 Tumor types: Adenomatous tumors Paraganglioma Neuromas/ acustic Meningioma (intratemporal) Schwannoma,Labyrinthine Inverted papilloma Hemangiopericytoma Fibromatosis Metastasis Middle Ear Adenomatous Tumors Histogenesis: Surface epithelium Stem / basal progenitor (no evidence for neuroendocrine cells) 18
19 Clinical Features: 2 nd to ninth decades No sex predilection Symptoms: Decreased hearing Ear fullness Tinitus Signs: Mass, middle ear cleft Discharge 19
20 Markers: Mucin: negative Endocrine markers: positive Chromogranin Synaptophysin 20
21 Differential Diagnosis: Ceruminous carcinoma: lateral 2/3 of the external ear canal Salivary choristoma Behavior: Non invasive: adenoma / carcinoid Bone destruction: adenocarcinoma/nec Merkel Cell Carcinoma 21
22 Origin: Metastasis: common Primary:? rare 22
23 Chromogranin Management: Chemo + XRT Conclusions: H&N NET Rare Heterogeneous Exclusion of mimics (D.D) 23
24 Thank you 24
Small (and large) Blue Cell Tumors of the Skull Base
Small (and large) Blue Cell Tumors of the Skull Base Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University of Arkansas for
More informationHead and Neck Squamous Subtypes
1 Head and Neck Squamous Subtypes Adel K. El-Naggar, M.D., Ph.D. The University of Texas MD Anderson Cancer Center, Houston, Texas HNSCC 5 th -6 th most common cancer 400,000/year 50% mortality Considerable
More informationPitfalls in Sinonasal Pathology
Pitfalls in Sinonasal Pathology Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University of Arkansas for Medical Sciences jhunt2@uams.edu
More informationNon Small Cell Lung Cancer Histopathology ד"ר יהודית זנדבנק
Non Small Cell Lung Cancer Histopathology ד"ר יהודית זנדבנק 26.06.09 Lecture outlines WHO histological classification Macro/Micro assessment Early diagnosis Minimal pathology Main subtypes SCC, AdCa, LCLC
More informationDisclosure of Relevant Financial Relationships
Squamous entities of the thyroid: Reactive to Neoplastic Michelle D. Williams Associate Professor Dept of Pathology, Head & Neck Section University of Texas MD Anderson Cancer Center Disclosure of Relevant
More informationSouth East England General Histopathology EQA Scheme
South East England General Round a Final Case Analyses Cases 635 to 646 Circulated January February 2016 131 responses (89.73%) Prepared April 2016 Authorised by: Prof J Schofield Date: 19/4/2016 With
More informationSquamous Cell Carcinoma of Thyroid: possible thymic origin, so-called ITET/CASTLE 2012/03/22
Squamous Cell Carcinoma of Thyroid: possible thymic origin, so-called ITET/CASTLE 2012/03/22 History of ITET/CASTLE First Report Gross Appearance and Prognosis 1) Miyauchi A et al: Intrathyroidal epithelial
More information4/17/2015. Case 1. A 37 year old man with a 2.2 cm solitary left thyroid mass.
Case 1 A 37 year old man with a 2.2 cm solitary left thyroid mass. Case 1 Case 1 1 Case 1: Diagnosis? A. Benign B. Atypia of undetermined significance/follicular lesion of undetermined significance C.
More informationDifferential diagnosis of HCC
Hepatocellular Carcinoma Quest for an Ideal Immunohistochemical Panel Sanjay Kakar, MD UCSF Differential diagnosis of HCC Hepatocellular lesions Adenoma, FNH, HG dysplasia Adenocarcinoma CholangioCA, metastasis
More informationBasaloid neoplasms of the head and neck. Basaloid SCC. Clinico-pathologic features 5/5/11. Basaloid Tumors Head and Neck
Basaloid neoplasms of the head and neck Richard Jordan DDS PhD FRCPath Professor & Director UCSF Oral Pathology Laboratory University of California San Francisco Basaloid Tumors Head and Neck Basaloid
More informationThe Panel Approach to Diagnostics. Lauren Hopson International Product Specialist Cell Marque Corporation
The Panel Approach to Diagnostics Lauren Hopson International Product Specialist Cell Marque Corporation Cell Marque Rocklin, California About Cell Marque: IVD primary antibody manufacturer Distributors
More informationOberndofer 1907 Illeal Serotonin Secreting Tumor Carcinoid (Karzinoide)
GEP-NET Adel K. El-Naggar, M.D., Ph.D. The University of Texas MD Anderson Cancer Center, Houston, Texas Oberndofer 1907 Illeal Serotonin Secreting Tumor Carcinoid (Karzinoide) 1 Histogenesis 16 different
More informationGastric and Oesophageal Neuroendocrine tumours. Dr Tim Bracey, Consultant Pathologist MBChB PhD MRCS FRCPath
Gastric and Oesophageal Neuroendocrine tumours Dr Tim Bracey, Consultant Pathologist MBChB PhD MRCS FRCPath Intestinal (and BO) endocrine cells in crypt bases NE cell (granules towards vessels) Paneth
More informationCutaneous metastases. Thaddeus Mully. University of California, San Francisco Professor, Departments of Pathology and Dermatology
Cutaneous metastases Thaddeus Mully University of California, San Francisco Professor, Departments of Pathology and Dermatology DISCLOSURE OF RELATIONSHIPS WITH INDUSTRY Thaddeus Mully Course C005 Essential
More informationCase Scenario 1: Thyroid
Case Scenario 1: Thyroid History and Physical Patient is an otherwise healthy 80 year old female with the complaint of a neck mass first noticed two weeks ago. The mass has increased in size and is palpable.
More informationCharles Halsey, DVM, PhD, DACVP Pfizer, Inc. IHC Resources
Charles Halsey, DVM, PhD, DACVP Pfizer, Inc. IHC Resources 1 IHC Identification Targets Specimens Controls 2 Tissue controls Trouble Spots 3 The Key to Description IHC Description 4 Intermediate Filaments
More informationFNA Cytology of Metastatic Malignancies of Unknown Primary Site
FNA Cytology of Metastatic Malignancies of Unknown Primary Site Tarik M. Elsheikh Jan F. Silverman Pathologic Diagnosis of Metastasis Smaller specimens, less invasive techniques FNA cytology is highly
More informationA Century of observations
PARAGANGLIOMAS OF THE HEAD & NECK: AN OVERVIEW Michelle D. Williams, MD Associate Professor Dept. of Pathology Head & Neck Section UT MD Anderson Cancer Center Disclosure of Relevant Financial Relationships
More informationPathology of the Thyroid
Pathology of the Thyroid Thyroid Carcinoma Arising from Follicular Cells 2015-01-19 Prof. Dr. med. Katharina Glatz Pathologie Carcinomas Arising from Follicular Cells Differentiated Carcinoma Papillary
More informationLesions Mimicking Adenoid Cystic Carcinoma. Diagnostic Problems in Salivary Gland Pathology An Update 5/29/2009
Diagnostic Problems in Salivary Gland Pathology An Update Lesions Mimicking Adenoid Cystic Carcinoma Stacey E. Mills, M.D. W.S. Royster Professor of Pathology Director of Surgical and Cytopathology University
More informationCancers of unknown primary : Knowing the unknown. Prof. Ahmed Hossain Professor of Medicine SSMC
Cancers of unknown primary : Knowing the unknown Prof. Ahmed Hossain Professor of Medicine SSMC Definition Cancers of unknown primary site (CUPs) Represent a heterogeneous group of metastatic tumours,
More informationRadiology Pathology Conference
Radiology Pathology Conference Nadia F. Yusaf, M.D. PGY-3 1/29/2010 Presentation material is for education purposes only. All rights reserved. 2010 URMC Radiology Page 1 of 90 Case 1 60 year- old man presents
More informationRadiology Pathology Conference
Radiology Pathology Conference Sharlin Johnykutty,, MD, Cytopathology Fellow Sara Majewski, MD, Radiology Resident Friday, August 28, 2009 Presentation material is for education purposes only. All rights
More information57th Annual HSCP Spring Symposium 4/16/2016
An Unusual Malignant Spindle Cell Lesion to Involve the Breast Erinn Downs-Kelly, D.O. Associate Professor of Pathology University of Utah & ARUP Laboratories No disclosures Case 39 y/o female with no
More informationC.L. Davis Foundation Descriptive Veterinary Pathology Course
C.L. Davis Foundation 2015 Descriptive Veterinary Pathology Course IHC Resources IHC Identification Targets Antibodies Antibodies 1 Antibodies Specimens Antigen Retrieval Unmasks antigen epitopes Methods
More informationNeuroendocrine neoplasms of the head and neck and olfactory neuroblastoma. Diagnosis and classification
PATHOLOGICA 2017;109:14-30 Review - Study Group GIPaTeC Neuroendocrine neoplasms of the head and neck and olfactory neuroblastoma. Diagnosis and classification S. UCCELLA 1, G. OTTINI 1, C. FACCO 2, R.
More informationCase Report Primary Neuroendocrine Tumor of the Parotid Gland: A Case Report and a Comprehensive Review of a Rare Entity
Hindawi Publishing Corporation Case Reports in Otolaryngology Volume 2016, Article ID 6971491, 5 pages http://dx.doi.org/10.1155/2016/6971491 Case Report Primary Neuroendocrine Tumor of the Parotid Gland:
More information2018 SEER Solid Tumor Manual 2018 KCR SPRING TRAINING
2018 SEER Solid Tumor Manual 2018 KCR SPRING TRAINING Eight Groups are Revised for 2018 Head & Neck Colon (includes rectosigmoid and rectum for cases diagnosed 1/1/2018 forward) Lung (2018 Draft not yet
More informationCarcinoma of Unknown Primary site (CUP) in HEAD & NECK SURGERY
Carcinoma of Unknown Primary site (CUP) in HEAD & NECK SURGERY SEARCHING FOR THE PRIMARY? P r o f J P P r e t o r i u s H e a d : C l i n i c a l U n i t C r i t i c a l C a r e U n i v e r s i t y O f
More informationAppendix 4: WHO Classification of Tumours of the pancreas 17
S3.01 The WHO histological tumour type must be recorded. CS3.01a The histological type of the tumour should be recorded based on the current WHO classification 17 (refer to Appendices 4-7). Appendix 4:
More informationOverview. Call: You will not be assigned to be on call during this rotation. Overall Objectives
Goals and Objectives for the Otolaryngology-Head & Neck Anatomical Pathology and Radiology Rotation Resident PGY5 St. Joseph s Healthcare Hamilton, McMaster Hospital (1 four-week rotational block) Overview
More informationThe clinically challenging entity of liver metastasis from tumors of unknown primary
The clinically challenging entity of liver metastasis from tumors of unknown primary Xuchen Zhang, MD, PhD Associate Professor of Pathology Department of Pathology Yale University School of Medicine Liver
More informationSUPPLEMENTARY INFORMATION
Supplementary Table 1 trials currently open for patients with pheochromocytoma and/or paraganglima (from trials.gov) www.clinicaltrials.gov; Active PPGL trials Status Of Sunitinib In Patients With Recurrent
More informationThyroid pathology Practical part
Thyroid pathology Practical part My Algorithm After a good macroscopy and a microscopic overview of the lesion, I especially look at the capsule and the thyroid just above and just beneath the capsule.
More informationEpithelial tumors. Dr. F.F. Khuzin, PhD Dr. M.O. Mavlikeev
Epithelial tumors Dr. F.F. Khuzin, PhD Dr. M.O. Mavlikeev Epithelial tumors Tumors from the epithelium are the most frequent among tumors. There are 2 group features of these tumors: The presence in most
More informationProblem 1: Differential of Neuroendocrine Carcinoma 3/23/2017. Disclosure of Relevant Financial Relationships
Differential of Neuroendocrine Carcinoma Alain C. Borczuk,MD Weill Cornell Medicine Disclosure of Relevant Financial Relationships USCAP requires that all faculty in a position to influence or control
More informationTable of Contents. Preface xi. Acknowledgments xiii. Part I Overview of the Diagnostic Process 1. 1 Overview of Grading and Staging 3
Table of Contents Preface xi Acknowledgments xiii Part I Overview of the Diagnostic Process 1 1 Overview of Grading and Staging 3 Identification of the process 3 Identification of tumor types 5 Grading
More informationInsulinoma-associated protein (INSM1) is a sensitive and specific marker for lung neuroendocrine tumors in cytologic and surgical specimens
Insulinoma-associated protein (INSM1) is a sensitive and specific marker for lung neuroendocrine tumors in cytologic and surgical specimens Kartik Viswanathan, M.D., Ph.D New York Presbyterian - Weill
More informationBasal cell carcinoma 5/28/2011
Goal of this Presentation A practical approach to the diagnosis of cutaneous carcinomas and their mimics Thaddeus Mully, MD University of California San Francisco To review common non-melanoma skin cancers
More informationPitfalls in thyroid tumor pathology. Prof.Valdi Pešutić-Pisac MD, PhD
Pitfalls in thyroid tumor pathology Prof.Valdi Pešutić-Pisac MD, PhD Too many or... Tumour herniation through a torn capsule simulating capsular invasion fibrous capsule with a sharp discontinuity, suggestive
More informationObjectives. Salivary Gland FNA: The Milan System. Role of Salivary Gland FNA 04/26/2018
Salivary Gland FNA: The Milan System Dr. Jennifer Brainard Section Head Cytopathology Cleveland Clinic Objectives Introduce the Milan System for reporting salivary gland cytopathology Define cytologic
More informationKeratinizing Dysplasia and Select Variants of Head & Neck Squamous Cell Carcinoma
Keratinizing Dysplasia and Select Variants of Head & Neck Squamous Cell Carcinoma Napa Valley Pathology Conference Silverado Resort & Spa May 18, 2018 Bruce M. Wenig, MD Moffitt Cancer Center Tampa, FL
More information- RET/PTC rearrangement: 20% papillary thyroid cancer - RET: medullary thyroid cancer
Thyroid Cancer UpToDate: Introduction: Risk Factors: Biology: Symptoms: Diagnosis: 1. Lenvina is the first line therapy with powerful durable response and superior PFS in pts with RAI-refractory disease.
More informationNeoplasms of the Canine, Feline and Lemur Liver:
Neoplasms of the Canine, Feline and Lemur Liver: Classification and Prognosis Annual Seminar of the French Society of Veterinary Pathology John M. Cullen VMD PhD DACVP North Carolina State University Primary
More information04/13/2017. Sinonasal Pathology. Sinonasal Tract Pathology Outline. 24 th Annual Seminar in Pathology Pittsburgh, PA April 27, 2017
Sinonasal Pathology 24 th Annual Seminar in Pathology Pittsburgh, PA April 27, 2017 Bruce M. Wenig, MD Moffitt Cancer Center Tampa, FL Sinonasal Tract Pathology Outline Sinonasal (Schneiderian) papillomas
More information2010 Update. NAACCR Webinar Series 1 4/1/2010. Agenda. Access to 2010 Information. CSv2. Collecting Cancer Data: Soft Tissue Sarcoma
NAACCR 2009 2010 Webinar Series Collecting Cancer Data: Soft Tissue Sarcoma, Neuroendocrine Tumors (NET) and Gastrointestinal Stromal Tumors (GIST) Agenda Updates Soft Tissue Sarcoma Overview CSv2 MP/H
More information- Selected Tumors of the Skin Appendages - Primary vs. Metastasis
- Selected Tumors of the Skin Appendages - Primary vs. Metastasis Napa Valley 2018 Victor G. Prieto, MD, PhD Chair of Pathology UT MD Anderson Cancer Center vprieto@mdanderson.org Napa Valley in May Introduction
More informationPathology of Selected Head and Neck Lesions. Adel Assaad MD Department of Pathology
Pathology of Selected Head and Neck Lesions Adel Assaad MD Department of Pathology 1 NOSE Infections 2 Zygomycosis (Mucormycosis) Opportunistic infection caused by "bread mold fungi," including Rhizopus,
More informationCase 18. M75. Excision of mass on scalp. Clinically SCC. The best diagnosis is:
Case 18 M75. Excision of mass on scalp. Clinically SCC. The best diagnosis is: A. Pilomatrical carcinoma B. Adnexal carcinoma NOS C. Metastatic squamous cell carcinoma D.Primary squamous cell carcinoma
More informationIHC Panels as an Aid in Diagnostic Decision Making
IHC Antibody Test Selection Using a Panel Approach Steven Westra B.S. Reagent Product Specialist Leica Biosystems IHC Panels as an Aid in Diagnostic Decision Making Diagnostic Use of Tumors Using Algorithms
More informationFNA Cytology of Metastatic Malignancies of Unknown Primary Site
FNA Cytology of Metastatic Malignancies of Unknown Primary Site Tarik M. Elsheikh Cleveland Clinic Jan F. Silverman Alleghany Hospitals Pathologic Diagnosis of Metastasis Smaller specimens, less invasive
More informationObjectives. Terminology 03/11/2013. Pitfalls in the diagnosis of Gastroenteropancreatic Neuroendocrine Tumors. Pathology Update 2013
Pitfalls in the diagnosis of Gastroenteropancreatic Neuroendocrine Tumors Pathology Update 2013 Ozgur Mete, MD Consultant in Endocrine Pathology, Department of Pathology, University Health Network Assistant
More informationApplications of IHC. Determination of the primary site in metastatic tumors of unknown origin
Applications of IHC Determination of the primary site in metastatic tumors of unknown origin Classification of tumors that appear 'undifferentiated' by standard light microscopy Precise classification
More informationFINALIZED SEER SINQ QUESTIONS
0076 Source 1: WHO Class CNS Tumors pgs: 33 MP/H Rules/Histology--Brain and CNS: What is the histology code for a tumor originating in the cerebellum and extending into the fourth ventricle described as
More informationNEUROENDOCRINE DIFFERENTIATION IN EPITHELIAL TUMORS Marco Volante
NEUROENDOCRINE DIFFERENTIATION IN EPITHELIAL TUMORS Marco Volante University of Turin, San Luigi Hospital, Orbassano, Turin, Italy marco.volante@unito.it pure NE tum..a grey zone pure non-ne ca. 0% NE
More informationSalivary Gland Cytology
Salivary Gland Cytology Diagnostic challenges and potential pitfalls Tarik M. Elsheikh, MD Professor and Medical Director Anatomic Pathology Cleveland Clinic FNA Salivary Gland Lesions Indications Distinguish
More informationDisclosures. The Thin Red Line Between Neuropathology and Head & Neck Pathology. Introduction CASE 1. Current Issues Tihan
Disclosures I have nothing to disclose The Thin Red Line Between Neuropathology and Head & Neck Pathology Tarik Tihan, MD, PhD UCSF, Department of Pathology Neuropathology Division Introduction Three cases
More information04/10/2018. Intraductal Papillary Neoplasms Of Breast INTRADUCTAL PAPILLOMA
Intraductal Papillary Neoplasms Of Breast Savitri Krishnamurthy MD Professor of Pathology Deputy Division Head The University of Texas MD Anderson Cancer Center 25 th Annual Seminar in Pathology Pittsburgh,
More informationGOBLET CELL CARCINOID. Hanlin L. Wang, MD, PhD University of California Los Angeles
GOBLET CELL CARCINOID Hanlin L. Wang, MD, PhD University of California Los Angeles Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to
More informationGOBLET CELL CARCINOID
GOBLET CELL CARCINOID Hanlin L. Wang, MD, PhD University of California Los Angeles Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to
More informationHuman Papillomavirus and Head and Neck Cancer. Ed Stelow, MD
Human Papillomavirus and Head and Neck Cancer Ed Stelow, MD No conflict of interest Declaration Cancer 1974 Lancet Oncol 2016; 17: e477-8 JAMA 1984; 252: 1857 JAMA 1988;259(13):1943-1944 Clin Cancer Res
More informationSalivary Gland FNA ATYPICAL : Criteria and Controversies
Salivary Gland FNA ATYPICAL : Criteria and Controversies W.C. Faquin, M.D., Ph.D. Director, Head and Neck Pathology Massachusetts General Hospital Massachusetts Eye and Ear Infirmary Harvard Medical School
More informationCOLON AND RECTUM SOLID TUMOR RULES ABSTRACTORS TRAINING
COLON AND RECTUM SOLID TUMOR RULES ABSTRACTORS TRAINING COLON AND RECTUM SOLID TUMOR RULES Separate sections for: Introduction Changes from 2007 MP/H rules Equivalent Terms Terms that are NOT Equivalent
More informationThe role of immunohistochemistry in surgical pathology of the uterine corpus and cervix
The role of immunohistochemistry in surgical pathology of the uterine corpus and cervix Prof. Ben Davidson, MD PhD Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
More informationOther Sites. Table 2 Continued. MPH Rules 11/8/07. NAACCR Webinar Series 1
MPH s 11/8/07 Other s 1 Table 2 Continued Use this two-page table to select combination histology codes. Compare the terms in the diagnosis to the terms in Columns 1 and 2. If the terms match, code the
More informationFinancial disclosures
Cutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchc Geisel School of
More informationProceedings of the 36th World Small Animal Veterinary Congress WSAVA
www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)
More information2018 Grade PEGGY ADAMO, RHIT, CTR OCTOBER 11, 2018
1 2018 Grade PEGGY ADAMO, RHIT, CTR ADAMOM@MAIL.NIH.GOV OCTOBER 11, 2018 2 Acknowledgements Donna Hansen, CCR Jennifer Ruhl, NCI SEER Introduction 3 Histologic Type vs. Grade Credit: Dr. Kay Washington
More informationVULVAR CARCINOMA. Page 1 of 5
VULVAR CARCINOMA EXAMPLE OF A VULVAR CARCINOMA USING PROPOSED TEMPLATE Case: Invasive squamous cell carcinoma arising in D-VIN Tumor in left labia major Left partial vaginectomy and sentinel lymph node
More information5/22/2018. Keratinizing Dysplasia and Select Variants of Head & Neck Squamous Cell Carcinoma
Keratinizing Dysplasia and Select Variants of Head & Neck Squamous Cell Carcinoma Napa Valley Pathology Conference Silverado Resort & Spa May 18, 2018 Bruce M. Wenig, MD Moffitt Cancer Center Tampa, FL
More informationColon and Rectum: 2018 Solid Tumor Rules
2018 SEER Solid Tumor Manual 2018 KCR SPRING TRAINING Colon and Rectum: 2018 Solid Tumor Rules 1 Colon and Rectum Solid Tumor Rules Separate sections for: Introduction Changes from 2007 MP/H rules Equivalent
More informationTHYMIC CARCINOMAS AN UPDATE
THYMIC CARCINOMAS AN UPDATE Mark R. Wick, M.D. University of Virginia Medical Center Charlottesville, VA CARCINOMA OF THE THYMUS General Clinical Features No apparent gender predilection Age range of 35-75
More informationCalcitonin. 1
Calcitonin Medullary thyroid carcinoma (MTC) is characterized by a high concentration of serum calcitonin. Routine measurement of serum calcitonin concentration has been advocated for detection of MTC
More informationTHYROID TUMOR DIAGNOSIS: MARKER OF THE MONTH CLUB
THYROID TUMOR DIAGNOSIS: MARKER OF THE MONTH CLUB CHARACTERISTIC OF THE IDEAL TUMOR MARKER Specific Sensitive Easy to perform Easy to interpret Adaptable to FNA Reasonable cost (CHEAP) THYROID TUMOR MARKERS
More informationEnterprise Interest Nothing to declare
Enterprise Interest Nothing to declare Diagnoses one would not like to miss in soft tissue pathology early in your career Marta Sbaraglia, MD Department of Pathology Hospital of Treviso University of Padua
More informationLUNG CANCER. pathology & molecular biology. Izidor Kern University Clinic Golnik, Slovenia
LUNG CANCER pathology & molecular biology Izidor Kern University Clinic Golnik, Slovenia 1 Pathology and epidemiology Small biopsy & cytology SCLC 14% NSCC NOS 4% 70% 60% 50% 63% 62% 61% 62% 59% 54% 51%
More informationATLAS OF HEAD AND NECK PATHOLOGY METAPLASIA
Metaplasia is the conversion of one adult differentiated cell type to another. Generally it is the result of persistent cellular trauma and serves as a protective mechanism. Thus anteriorly along the nasal
More informationSCOPE TODAYS SESSION. Case 1: Case 2. Basic Theory Stuff: Heavy Stuff. Basic Questions. Basic Questions
MONDAY TEACHING SCOPE TODAYS SESSION Case 1: Basic Questions Case 2 Basic Questions Basic Theory Stuff: AJCC TNM + Stage Group for Carcinoid of the Appendix Management of Carcinoid of the Appendix (NCCN)
More informationCASE REPORT A RARE CASE OF MIDDLE EAR ADENOMA
Nagoya J. Med. Sci. 76. 355 ~ 360, 2014 CASE REPORT A RARE CASE OF MIDDLE EAR ADENOMA MASAYO BAKU and HIROMI UEDA Department of Otorhinolaryngology, Aichi Medical University, Nagakute, Japan ABSTRACT Middle
More informationFINALIZED SEER SINQ QUESTIONS January June, 2016
20160046 MP/H Rules/Multiple primaries/histology--rectum: How many primaries does this person have and what is the correct histology? See discussion. Rectal polyp excised in June, 2012, found to have adenocarcinoma
More informationSmall cell neuroendocrine carcinoma icd 10
Small cell neuroendocrine carcinoma icd 10 1-10-2017 Free, official coding info for 2018 ICD - 10 -CM C34.90 - includes detailed rules, notes, synonyms, ICD -9- crosswalks, DRG. In most series, LCLC's
More informationPathology Mystery and Surprise
Pathology Mystery and Surprise Tim Smith, MD Director Anatomic Pathology Medical University of South Carolina Disclosures No conflicts to declare Some problem cases Kidney tumor Scalp tumor Bladder tumor
More informationB. Environmental Factors. a. The major risk factor to papillary thyroid cancer is exposure to ionizing radiation, during the first 2 decades of life.
B. Environmental Factors. a. The major risk factor to papillary thyroid cancer is exposure to ionizing radiation, during the first 2 decades of life. b. Deficiency of dietary iodine: - Is linked with a
More informationLung Tumor Cases: Common Problems and Helpful Hints
Lung Tumor Cases: Common Problems and Helpful Hints Brandon T. Larsen, MD, PhD Senior Associate Consultant Department of Laboratory Medicine and Pathology Mayo Clinic Arizona Arizona Society of Pathologists
More informationMody. AIS vs. Invasive Adenocarcinoma of the Cervix
Common Problems in Gynecologic Pathology Michael T. Deavers, M.D. Houston Methodist Hospital, Houston, Texas Common Problems in Gynecologic Pathology Adenocarcinoma in-situ (AIS) of the Cervix vs. Invasive
More informationImpact of immunostaining of pulmonary and mediastinal cytology
Impact of immunostaining of pulmonary and mediastinal cytology Harman Sekhon MD, PhD Director of Cytopathology Head of Ottawa-site Ontario Tumour Bank June 20, 2014 Disclaimer Pfizer: Honorarium-Advisory
More informationCase Report A Case of Typical Carcinoid of the Larynx
Case Reports in Otolaryngology Volume 2012, Article ID 717251, 5 pages doi:10.1155/2012/717251 Case Report A Case of Typical Carcinoid of the Larynx Shintaro Sato, 1 Yuichiro Kuratomi, 1 Fumio Yamasaki,
More information4/12/2018. MUSC Pathology Symposium Kiawah Island April 18, Jesse K. McKenney, MD
MUSC Pathology Symposium Kiawah Island April 18, 2018 Jesse K. McKenney, MD 1 Urothelial Carcinoma with Alternative Differentiation 2 Urothelial Carcinoma with Alternative Differentiation Recognition as
More informationEQA Circulation 43 Educational Cases
EQA Circulation 43 Educational Cases E1-E2 Monica Agarwal Monklands Hospital E1 38 yrs male Submandibular gland tumour E1 Formal excision following diagnosis of poorly differentiated carcinoma on core
More informationCase Report Calcitonin-Secreting Neuroendocrine Carcinoma of Larynx with Metastasis to Thyroid
Case Reports in Endocrinology Volume 2015, Article ID 606389, 6 pages http://dx.doi.org/10.1155/2015/606389 Case Report Calcitonin-Secreting Neuroendocrine Carcinoma of Larynx with Metastasis to Thyroid
More informationSlide seminar: Soft tissue and bone pathology
Slide seminar: Soft tissue and bone pathology Unusual tumors of bone and soft tissue or unusual presentations of common ones Gunhild Mechtersheimer Institute of Pathology, Heidelberg/DE (Sylvia Höller,
More informationFig. 59 Malignant phaeochromocytoma, hepatic metastasis.
Fig. 59 Malignant phaeochromocytoma, hepatic metastasis. X 120 Hyperte nsion Fig. 60 Malignant sympathetic paraganglioma, lymph node metastasis Primary in bladder. x 1 20 Hypertension Fig. 61 Malignant
More informationFast, automated, precise
Thermo Scientific B R A H M S / NSE Immunodiagnostic Assays Fast, automated, precise Neuroendocrine tumor markers on KRYPTOR Systems First and only fully automated CgA assay worldwide Shortest time to
More informationUrinary Bladder: WHO Classification and AJCC Staging Update 2017
Urinary Bladder: WHO Classification and AJCC Staging Update 2017 Houston Society of Clinical Pathologists 58 th Annual Spring Symposium Houston, TX April 8, 2017 Jesse K. McKenney, MD Classification
More informationCase year old female presented with asymmetric enlargement of the left lobe of the thyroid
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationCutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement
Cutaneous Mesenchymal Neoplasms with EWSR1 Rearrangement By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center
More informationCase 4 Diagnosis 2/21/2011 TGB
Case 4 22 year old female presented with asymmetric enlargement of the left lobe of the thyroid gland. No information available relative to a prior fine needle aspiration biopsy. A left lobectomy was performed.
More informationFACULTY MEMBERSHIP APPLICATION Tulane Cancer Center
FACULTY MEMBERSHIP APPLICATION Tulane Cancer Center 1430 Tulane Ave., Box SL-68, New Orleans, LA 70112-2699 J. Bennett Johnston Building, Mezzanine (Floor 1A), Suite A102 (504) 988-6060, fax (504) 988-6077,
More informationAssistant Professor, Department of Medical Oncology, ILBS, Vasant Kunj, New Delhi
Open Journal of Clinical & Medical Case Reports Volume 4 (2018) Issue 5 ISSN 2379-1039 Calcitonin negative neuroendocrine carcinoma of thyroid: A rare case Saphalta Baghmar, DM*; Archana Rastogi, MD, DNB;
More informationCase Report Pigmented adenoid cystic carcinoma of the ear skin arising from the epidermis: a case report with immunohistochemical
Int J Clin Exp Pathol 2012;5(3):254-259 www.ijcep.com /ISSN: 1936-2625/IJCEP1110004 Case Report Pigmented adenoid cystic carcinoma of the ear skin arising from the epidermis: a case report with immunohistochemical
More information