EFFICACY OF NECK DISSECTION FOR LOCOREGIONAL FAILURES VERSUS ISOLATED NODAL FAILURES IN NASOPHARYNGEAL CARCINOMA
|
|
- Eleanor Williamson
- 5 years ago
- Views:
Transcription
1 ORIGINAL ARTICLE EFFICACY OF NECK DISSECTION FOR LOCOREGIONAL FAILURES VERSUS ISOLATED NODAL FAILURES IN NASOPHARYNGEAL CARCINOMA Raymond King Yin Tsang, FRCSEd, Joseph Chun Kit Chung, MRCSEd, Yiu Wing Ng, MRCSEd, Victor Shing Howe To, FRCSEd, Ambrose Chung Wai Ho, FRCSEd, Jimmy Yu Wai Chan, FRCSEd, Wai Kuen Ho, FRCSEd, William Ignace Wei, FRCS Department of Surgery, Division of Otorhinolaryngology Head and Neck Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China. Accepted 16 February 2011 Published online 17 June 2011 in Wiley Online Library (wileyonlinelibrary.com). DOI: /hed Abstract: Background. Neck dissection has been shown to be effective in controlling nodal failures in nasopharyngeal carcinoma. Its efficacy in controlling the disease in patients with synchronous locoregional failure is, however, not documented. Method. A retrospective review of all patients who underwent neck dissection for nodal failures with or without treated local failure within 6 months was conducted for this study. The survivals of these 2 groups of patients were analyzed. Results. The 5-year overall survival of the whole cohort was 58%. There was no difference in 5-year disease specific survival (68% vs 40%; p ¼.121) and 5-year progression free survival (44% vs 36%; p ¼.334) when comparing patients with isolated nodal failures and synchronous locoregional failures. Multivariate analysis showed that only the initial N classification affects survival. Conclusion. Neck dissection is efficacious in patients with nasopharyngeal carcinoma with nodal failure, with or without synchronous local failures. VC 2011 Wiley Periodicals, Inc. Head Neck 34: , 2012 Keywords: nasopharyngeal carcinoma; locoregional recurrence; nodal recurrence; neck dissection; salvage surgery The management of nasopharyngeal carcinoma (NPC) has markedly improved after the introduction of concurrent chemoradiation. 1 Isolated nodal failures after chemoradiation are now uncommon, ranging from 3.5% to 6.9%. 2,3 Surgical salvage, in the form of radical neck dissection, has been shown to be more effective than reirradiation in controlling the nodal disease. Sham and Choy 4 reported that the overall 5-year survival of only 19.7% of patients with nodal recurrence were treated by a second course of external radiotherapy. Our center has reported a 5-year actuarial survival of 38% after radical neck dissection for control of nodal disease after radiotherapy 20 years ago. 5 In our center, radical neck dissection has Correspondence to: R. K. Y. Tsang VC 2011 Wiley Periodicals, Inc. been the standard treatment for regional failure for patients with NPC. Occasionally, a patient who presented with nodal recurrence also had local recurrence. Chua et al 6 reported that 12% of patients with local recurrence of NPC also had synchronous nodal recurrence. In patients with synchronous locoregional failures, the treatment decision can be difficult. Although both the local and regional disease itself is amenable to salvage treatment, the combined morbidity of managing both local and regional disease might be significant. The treatment approach to one site may be affected by the choice of treatment to the other site. Finally, synchronous locoregional disease may carry a significantly worse prognosis even after successful salvage, thus less radical treatments were usually used in this group of patients. We reviewed the outcome of patients undergoing neck dissection for nodal failures after NPC treatment and reviewed if patients with locoregional recurrence have significantly worse prognosis after neck dissection than patients with isolated nodal failure. The primary objective is to determine whether there is any difference in survival in patients with NPC who had concurrent locoregional failures compared with patients with isolated nodal failure after treatment with salvage neck dissection. The second objective was to analyze any factors that would influence survival, including initial stage of disease, recurrent stage of disease, age, sex, recurrent or persistent disease, the presence of extracapsular spread, and the use of brachytherapy after neck dissection. PATIENTS AND METHODS From January 1999 to December 2008, 64 consecutive patients had neck dissection with a curative intent for salvage of nodal failures after radiotherapy for nasopharyngeal carcinoma in the Department of Surgery, University of Hong Kong Medical Centre. Among the 64 patients, there were 42 men and Salvage Neck Dissection in NPC HEAD & NECK DOI /hed May 2012
2 women. Median age was 46.5 and ranged from 26 to 71 years old. Follow-up of patients who survived ranged from 8 to 129 months with median follow-up of 6 years. Patients who had neck dissection and treatment of local recurrence within 6 months were considered as synchronous locoregional recurrence. Thirty-four patients had isolated nodal recurrence. Eighteen patients had synchronous locoregional recurrence. Seven patients had local recurrence more than 6 months before the nodal recurrence and all were local disease-free when they received the neck dissection. Five patients developed isolated recurrence at the nasopharynx more than 6 months after neck dissection for nodal recurrence and are considered as disease progression. The 12 patients from the last 2 groups were grouped together in the group of isolated nodal recurrence during analysis. All patients have undergone evaluation for their locoregional failures, which included clinical examination, nasopharyngoscopy and biopsy of the nasopharynx, ultrasonography of the neck, and fineneedle aspiration of the suspicious lymph nodes. Blood was taken for complete blood count, renal and liver biochemistry, and creatinine clearance. Chest x-rays were also performed. All patients with suspected local recurrence would have cross-sectional imaging performed in addition, either a CT scan or MRI of the nasopharynx. The 18-fluorodeoxyglucose (FDG) positron emission tomography scans were frequently used in recent years. All patients had their initial disease and recurrent disease restaged with the 2002 Union Internationale Contre le Cancer (UICC) staging system. 7 For the initial staging of the nasopharyngeal carcinoma, 1 patient (1.6%) had stage I disease, 20 patients (31.3%) had stage II disease, 18 patients (28.1%) had stage III disease, and 9 (14.1%) patients had stage IV disease. Staging information was missing in 16 patients (25%) as they were referred for salvage treatment from other institutions. We arbitrarily define persistent nodal disease as failure diagnosed within 6 month after primary radiotherapy. Using this definition, there were 6 patients with persistent disease, with 1 patient having concurrent local and regional persistent disease. For the staging of the nodal failures, 5 patients (7.8%) had no tumor in the neck dissection specimen. The decision to proceed to neck dissection in this group of patients was based on clinical and radiological suspicion and findings of atypical cells on fine-needle aspiration. Forty-six patients (71.9%) had rn1 disease, 10 patients (15.6%) had rn2 disease, and 3 patients (4.7%) had rn3 disease. Seven patients had extensive nodal disease with close or positive margins and received brachytherapy in the form of iridium-192 wire after-loading at the time of radical neck dissection. Four patients had bilateral nodal failures and received bilateral modified radical neck dissections. Pathological examination of the neck dissection specimens showed that 5 patients had positive resection margin and 16 specimens showed 1 or more lymph nodes having extracapsular spread. For recurrent or residual disease at the primary site, aggressive salvage procedures were carried out for these patients whenever applicable. Salvage treatment was either in the form of gold grain implant 8 or nasopharyngectomy via a maxillary swing approach. 9 Five patients received gold grain implants and 12 patients received nasopharyngectomy. One patient developed local recurrence 3 months after neck dissection and refused treatment to the local recurrent disease. The clinical oncologist and head and neck surgeon jointly decided on the choice of treatment for local failure. Later in the series, the radioactive gold grain was not done and all local recurrences were salvaged with nasopharyngectomy via a maxillary swing approach. All patients were followed up monthly in the first year after treatment, every 2 months in the second year, and every 3 months from the third year onward. For the calculation of disease-specific survival (DSS), patients that died not due to the recurrent cancer would be considered as censored at the date of death and not counted as died of disease. For the calculation of progression-free survival (PFS), the date of detection of any recurrent local or nodal disease or distant metastasis would be counted as disease progression. The overall survival (OS), DSS, and PFS rates were calculated using the Kaplan Meier method. Univariate analysis of survival between groups was calculated with the Kaplan Meier method 10 and logrank test. The Cox proportional hazard regression model was used for multivariate analysis of survival. 11 The chi-square and Fisher exact test were used in calculation of significance in cross-tabulations. Statistical significance is defined as p <.05. All statistics are calculated with SPSS 18.0 (Chicago, IL). RESULTS Disease-specific Survival and Progression Free Survival. There was no 30-day postoperative mortality. One patient, who underwent a nasopharyngectomy together with a neck dissection, died of carotid blow out in the nasopharynx 2 months after treatment. Three patients died of other causes, 43, 89, and 96 months after the neck dissection. The mean interval and median interval between the completion of radiotherapy to regional failure in recurrent disease were 48.9 months and 34 months (range, months). For the whole cohort of 64 patients, the overall 5-year survival was 58%. The 5-year DSS rate was 60%; the 5-year PFS rate was 42%. Figure 1 and Figure 2 showed the DSS and PFS plots of the whole cohort. Analyzing the subgroup with isolated nodal failures, the 5-year DSS was 68%; the 5-year PFS was 44%. For the group of patients with synchronous locoregional disease, the 5-year DSS was 40%; the Salvage Neck Dissection in NPC HEAD & NECK DOI /hed May
3 Table 1. Summary of survival results. Diseasespecific survival Progressionfree survival 3y 5y 3y 5y Whole cohort 74% 60% 49% 42% Isolated nodal failures 74% 68% 51% 44% Synchronous locoregional failures 74% 40% 50% 36% FIGURE 1. Disease-specific survival plot of the whole cohort of 64 patients. 5-year PFS rate was 36%. Table 1 summarizes the results of the survival analysis. Using the Kaplan Meier model for analysis of difference in survival, the survival rates of the 2 groups were not statistically significant (p ¼.121 for DSS and p ¼.334 for PFS, log-rank tests). Figure 3 and Figure 4 showed the Kaplan Meier plot of DSS and PFS of the 2 groups. Multivariate Analysis. Multivariate analysis using the Cox regression model showed that only the initial N classification affects the DSS, (relative risk, 2.04; 95% confidence interval [CI], ; p ¼.011). Both the age and the recurrent N classification affect the PFS. The relative risk of age on the PFS was 1.07 (95% CI, ; p ¼.026) and relative risk of recurrent N classification was 2.23 (95% CI, ; p ¼.046). Table 2 and Table 3 summarized the statistics of the Cox regression analysis of the prognostic factors. Relapse and Disease Progression. Of the whole cohort, 29 of the patients (45.3%) were disease free at the time of the study. The mean and median survival after relapse was 19.5 and 11.5 months, but ranged from 1 month to a maximum of 96 months. Eight patients (12.5%) presented with local recurrence, whereas 9 patients (14%) had their relapse presented as distant metastasis. Nodal recurrence was the commonest form of failure with 18 patients (28.1%) suffering from nodal relapse. DISCUSSION Neck dissection has been shown to be superior to reirradiation in controlling nodal failures in NPC. 4,12 Previous irradiation limits the amount of radiation that can be given in re-treatment without significant toxicities to vital structures like the spinal cord. Moreover, the tumor cells had survived previous radiotherapy to present as relapse; this clone of tumor cells might be radioresistant. Reirradiation is also associated with significant early and late morbidities. Surgery, in the form of radical neck dissection, is still the treatment of choice for nodal failures in NPC. A report from our institution 20 years ago showed a 5-year nodal control rate of 66% and a 5-year OS rate of 38%. 5 In our current series, the 5-year OS had increased to 58%. This improvement in survival may be due to improved imaging techniques FIGURE 2. Progression-free survival plot of the whole cohort of 64 patients. FIGURE 3. Kaplan-Meier plot of disease-specific survival of patients with isolated nodal failures and synchronous locoregional failures (p ¼.121, log-rank test). 640 Salvage Neck Dissection in NPC HEAD & NECK DOI /hed May 2012
4 Table 3. Summary of result of multivariate analysis on progression-free survival. Variable patients patients with disease progression Multivariate analysis p value (Cox regression) FIGURE 4. Kaplan Meier plot of progression-free survival of patients with isolated nodal failures and synchronous locoregional failures (p ¼.334, log-rank test). Variable Table 2. Summary of the results of multivariate analysis on disease free survival. patients patients died of disease Multivariate analysis p value (Cox regression) Sex.438 Male (40.5%) Female (50%) Age.077 Median 46.5 (26 71) Initial T classification.509 T (45.5%) T (36.7%) T3 6 1 (16.7%) T4 1 1 (100%) Initial N classification.011 N0 6 1 (16.7%) N (33.3%) N (33.3%) N3 9 6 (66.7%) Persistent nodal disease.342 Yes 6 3 (50%) No (43.1%) Pathologic rn classification.160 rn0 5 2 (40%) rn (36.5%) rn2 4 1 (25%) rn3 3 2 (66.6%) Synchronous locoregional recurrence.388 Yes (58.8%) No (38.3%) Brachytherapy.579 Yes 7 4 (57.1%) No (42.1%) Positive margin.202 Yes 9 7 (77.8%) No (38.2%) Extracapsular spread.949 Yes (43.5%) No (37.8%) Note: Initial T and N classification of 16 patients were missing. Sex.342 Male Female Age.026 Median 46.5 (26 71) Initial T classification.278 T T T3 6 3 T4 1 1 Initial N classification.105 N0 6 3 N N N3 9 7 Persistent nodal disease.954 Yes 6 3 No Pathologic rn classification.046 rn0 5 2 rn rn2 4 4 rn3 3 2 Synchronous locoregional recurrence.438 Yes No Brachytherapy.460 Yes 7 5 No Positive margin.180 Yes 9 7 No Extracapsular spread.994 Yes No Note: Initial T and N classification of 16 patients were missing due to tertiary referral. and early detection of nodal failures, leading to more successful salvage. Alternatively, newer palliative treatment may slow down the disease progression and prolong the OS of patients with recurrent disease, but we have no data to prove this assumption. Our institution has previously reported on a series of 13 patients treated with interstitial brachytherapy in addition to radical neck dissection for salvage of nodal failures in NPC in a 7-year period from the year 1990 to There have only been 7 cases of interstitial brachytherapy in addition to radical neck dissection for salvage of nodal failures in the current 10-year cohort. The drop in usage of interstitial brachytherapy in conjunction with neck dissection is likely due to the efficacy of concurrent chemoradiation in controlling bulky nodal disease and the improvement in diagnostic imaging allowing nodal diseases to be detected before the disease becomes fixed to skin or neck structures. It was reported in the literature that 8% to 28% of patients with local failures also have regional Salvage Neck Dissection in NPC HEAD & NECK DOI /hed May
5 failures. 6,14 16 Although aggressive treatment is usually offered to patients with either local or regional failures, efficacy of similar aggressive treatments to both local and regional disease in patients with synchronous locoregional failures was not defined. This is because we are uncertain about the prognosis of patients with concurrent locoregional failure and the fear of excessive treatment-related morbidities. In this cohort, we are unable to show any statistical difference in survival of patients with isolated nodal failures who have received neck dissection and patients with synchronous locoregional failures who have received neck dissection and treatment to the local disease. From the multivariate analysis, the only significant predictor of DSS is the initial N classification. On the other hand, the recurrent N classification predicts PFS. From the data, we are not able to provide a satisfactory explanation of the findings in the multivariate analysis. Although age has been shown to be a statistically significant predictor in PFS, the relative risk is very low (1.07, 95% CI, ) and is clinically not significant. There has been 1 report in the literature on the use of concurrent chemoirradiation to treat locoregionally recurrent NPC. 17 The response rate was 58% and the reported 5-year OS and PFS was 26% and 15% only. Grade 3 to 4 late toxicities were significant, up to 23%. In that series of 35 patients, there were 23 patients with advanced (rt3 rt4) local disease. The advanced local disease may explain the worse survival when compared with the current cohort. Further studies are required to compare the efficacy and toxicities of surgery versus reirradiation with concurrent chemotherapy in patients with NPC with small locoregional failures. In our unit, the treatment of choice for small local recurrence of NPC was nasopharyngectomy. The operative risk is small and long-term morbidity of patients who have received this operation is acceptable. 18 With suitable precaution and meticulous surgery, the morbidity of radical neck dissection is low and is more effective than radiotherapy in controlling nodal failures in patients with NPC. Our current cohort demonstrated that 1 in 3 patients with synchronous locoregional failure survived for 5 years after radical treatment. We would advocate an aggressive approach in managing synchronous locoregional failures in NPC. For patients with small local disease and resectable nodal disease, we advocate a combined nasopharyngectomy and radical neck dissection aiming for a cure. For patients with unresectable recurrent disease in the nasopharynx, it is uncertain that radical neck dissection together with external beam reirradiation to the nasopharynx would offer survival benefits. Further studies in this subgroup of patients would be required before we can advocate an aggressive surgical approach. In summary, there is no statistical difference in the survival of patients with NPC with synchronous locoregional failure who have received a radical neck dissection and curative treatment to the local disease when compared to patients with NPC with isolated nodal failures who have received radical neck dissection. The 5-year OS of patients with NPC who have received radical neck dissection for salvage of nodal failure is 58%. Radical neck dissection is effective in controlling nodal failures in patients with NPC. REFERENCES 1. Al Sarraf M, LeBlanc M, Giri PG, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study J Clin Oncol 1998;16: Lee AW, Lau WH, Tung SY, et al. Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. J Clin Oncol 2005;23: Leung TW, Tung SY, Sze WK, et al. Treatment results of 1070 patients with nasopharyngeal carcinoma: an analysis of survival and failure patterns. Head Neck 2005;27: Sham JS, Choy D. Nasopharyngeal carcinoma: treatment of neck node recurrence by radiotherapy. Australas Radiol 1991;35: Wei WI, Lam KH, Ho CM, Sham JS, Lau SK. Efficacy of radical neck dissection for the control of cervical metastasis after radiotherapy for nasopharyngeal carcinoma. Am J Surg 1990;160: Chua DT, Sham JS, Kwong DL, Wei WI, Au GK, Choy D. Locally recurrent nasopharyngeal carcinoma: treatment results for patients with computed tomography assessment. Int J Radiat Oncol Biol Phys 1998;41: International Union Against Cancer. TNM Classification of Malignant Tumours. 6th ed. New York: Wiley; Kwong DL, Wei WI, Cheng AC, et al. Long term results of radioactive gold grain implantation for the treatment of persistent and recurrent nasopharyngeal carcinoma. Cancer 2001;91: Wei WI, Ho CM, Yuen PW, Fung CF, Sham JS, Lam KH. Maxillary swing approach for resection of tumors in and around the nasopharynx. Arch Otolaryngol Head Neck Surg 1995;121: Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53: Cox DR, Oakes D. Analysis of survival data. London: Chapman and Hall; Chua DT, Wei WI, Sham JS, Cheng AC, Au G. Treatment outcome for synchronous locoregional failures of nasopharyngeal carcinoma. Head Neck 2003;25: Wei WI, Ho WK, Cheng AC, et al. Management of extensive cervical nodal metastasis in nasopharyngeal carcinoma after radiotherapy: a clinicopathological study. Arch Otolaryngol Head Neck Surg 2001;127: Hwang JM, Fu KK, Phillips TL. Results and prognostic factors in the retreatment of locally recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 1998;41: Leung TW, Tung SY, Sze WK, Sze WM, Wong VY, O SK. Salvage brachytherapy for patients with locally persistent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2000;47: Teo PM, Kwan WH, Chan AT, Lee WY, King WW, Mok CO. How successful is high-dose (> or ¼ 60 Gy) reirradiation using mainly external beams in salvaging local failures of nasopharyngeal carcinoma? Int J Radiat Oncol Biol Phys 1998;40: Poon D, Yap SP, Wong ZW, et al. Concurrent chemoradiotherapy in locoregionally recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2004;59: Ng RW, Wei WI. Quality of life of patients with recurrent nasopharyngeal carcinoma treated with nasopharyngectomy using the maxillary swing approach. Arch Otolaryngol Head Neck Surg 2006;132: Salvage Neck Dissection in NPC HEAD & NECK DOI /hed May 2012
Clinical features and prognostic factors in patients with nasopharyngeal carcinoma relapse after primary treatment
Page 1 of 7 Clinical features and prognostic factors in patients with nasopharyngeal carcinoma relapse after primary treatment X Peng 1, SF Chen 2, C Du 2 *, P Yang 2, SX Liang 2, G Zhang 3, X Dong 4 *,
More informationAccepted 24 October 2007 Published online 22 January 2008 in Wiley InterScience (www.interscience.wiley.com). DOI: /hed.
ORIGINAL ARTICLE PHASE II STUDY OF GEFITINIB FOR THE TREATMENT OF RECURRENT AND METASTATIC NASOPHARYNGEAL CARCINOMA Daniel T. T. Chua, MD, 1 William I. Wei, MD, 2 Maria P. Wong, MD, 3 Jonathan S. T. Sham,
More informationNew modalities in the salvage of recurrent nasopharyngeal carcinoma
New modalities in the salvage of recurrent nasopharyngeal carcinoma Dr Jeeve Kanagalingam FRCS Eng (ORL-HNS) Department of Otorhinolaryngology Tan Tock Seng Hospital SINGAPORE Nasopharyngeal carcinoma
More informationMAIN ARTICLE S-T TOH 1, H-W YUEN 3, K-H LIM 2, Y-H GOH 1, H-K C GOH 1
The Journal of Laryngology & Otology (2011), 125, 70 77. JLO (1984) Limited, 2010 doi:10.1017/s0022215110001933 MAIN ARTICLE Residual cervical lymphadenopathy after definitive treatment of nasopharyngeal
More informationA variation in recurrence patterns of papillary thyroid cancer with disease progression: A long-term follow-up study
ORIGINAL ARTICLE A variation in recurrence patterns of papillary thyroid cancer with disease progression: A long-term follow-up study Joon-Hyop Lee, MD, Yoo Seung Chung, MD, PhD,* Young Don Lee, MD, PhD
More informationTreatment outcomes and prognostic factors of gallbladder cancer patients after postoperative radiation therapy
Korean J Hepatobiliary Pancreat Surg 2011;15:152-156 Original Article Treatment outcomes and prognostic factors of gallbladder cancer patients after postoperative radiation therapy Suzy Kim 1,#, Kyubo
More informationORIGINAL ARTICLE. Predicting the Prognosis of Oral Squamous Cell Carcinoma After First Recurrence
ORIGINAL ARTICLE Predicting the Prognosis of Oral Squamous Cell Carcinoma After First Recurrence Michael D. Kernohan, FDSRCS, FRCS, MSc; Jonathan R. Clark, FRACS; Kan Gao, BEng; Ardalan Ebrahimi, FRACS;
More informationNasopharyngeal carcinoma time lapse before diagnosis and treatment
Nasopharyngeal carcinoma time lapse before diagnosis and treatment AWM Lee, WM Ko, W Foo, P Choi, Y Tung, J Sham, B Cheng, G Au, WH Lau, D Choy, SK O, WM Sze, KC Tse, CK Law, P Teo, TK Yau, WH Kwan This
More informationSummary. Joanna Terlikiewicz 1,2, Roman Makarewicz 1,2, Andrzej Lebioda 1,2, Renata Kabacińska 2,3, Marta Biedka 2
Original Paper Received: 2004.11.23 Accepted: 2005.06.15 Published: 2005.09.20 An analysis of outcomes, after re-irradiation by HDR (high-dose-rate) brachytherapy, among patients with locally recurrent
More informationTreatment and prognosis of patients with recurrent laryngeal carcinoma: a retrospective study
Page 1 of 7 Treatment and prognosis of patients with recurrent laryngeal carcinoma: a retrospective study T Jin 1, H Lin 2,3, HX Lin 2,3, XY Cai 2,3, HZ Wang 2,3, WH Hu 2,3, LB Guo 4, JZ Zhao 5 * Abstract
More informationABSTRACT INTRODUCTION
/, 2017, Vol. 8, (No. 26), pp: 43450-43457 The challenge in treating locally recurrent T3-4 nasopharyngeal carcinoma: the survival benefit and severe late toxicities of reirradiation with intensity-modulated
More informationCharacteristics and prognostic factors of synchronous multiple primary esophageal carcinoma: A report of 52 cases
Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Characteristics and prognostic factors of synchronous multiple primary esophageal carcinoma: A report of 52 cases Mei Li & Zhi-xiong Lin Department of Radiation
More informationLong term survival study of de-novo metastatic breast cancers with or without primary tumor resection
Long term survival study of de-novo metastatic breast cancers with or without primary tumor resection Dr. Michael Co Division of Breast Surgery Queen Mary Hospital The University of Hong Kong Conflicts
More informationLong-term Follow-up for Patients with Papillary Thyroid Carcinoma Treated as Benign Nodules
Long-term Follow-up for Patients with Papillary Thyroid Carcinoma Treated as Benign Nodules YASUHIRO ITO, TAKUYA HIGASHIYAMA, YUUKI TAKAMURA, AKIHIRO MIYA, KAORU KOBAYASHI, FUMIO MATSUZUKA, KANJI KUMA
More informationSTEREOTACTIC RADIOSURGERY PLUS INTRACAVITARY IRRADIATION IN THE SALVAGE OF NASOPHARYNGEAL CARCINOMA
STEREOTACTIC RADIOSURGERY PLUS INTRACAVITARY IRRADIATION IN THE SALVAGE OF NASOPHARYNGEAL CARCINOMA John S. H. Low, MRCP, FRCR, 1 Eu-Tiong Chua, DMRT, FRCR, 1 Fei Gao, PhD, 2 Joseph T. S. Wee, FRCR 1,2
More informationSelf-Assessment Module 2016 Annual Refresher Course
LS16031305 The Management of s With r. Lin Learning Objectives: 1. To understand the changing demographics of oropharynx cancer, and the impact of human papillomavirus on overall survival and the patterns
More informationCACA. Original Article
Chinese Journal of Cancer Original Article Xing Lu 1,2*, Fei 鄄 Li Wang 1,2*, Xiang Guo 1,2, Lin Wang 1,2, Hai 鄄 Bo Zhang 1,2, Wei 鄄 Xiong Xia 1,2, Si 鄄 Wei Li 1,2, Ning 鄄 Wei Li 1,2, Chao 鄄 Nan Qian 1,2
More informationLocoregional recurrences are the most frequent
ORIGINAL ARTICLE SECOND SALVAGE SURGERY FOR RE-RECURRENT ORAL CAVITY AND OROPHARYNX CARCINOMA Ivan Marcelo Gonçalves Agra, MD, PhD, 1 João Gonçalves Filho, MD, PhD, 2 Everton Pontes Martins, MD, PhD, 2
More informationSurvival impact of cervical metastasis in squamous cell carcinoma of hard palate
Vol. 116 No. 1 July 2013 Survival impact of cervical metastasis in squamous cell carcinoma of hard palate Quan Li, MD, a Di Wu, MD, b,c Wei-Wei Liu, MD, PhD, b,c Hao Li, MD, PhD, b,c Wei-Guo Liao, MD,
More informationORIGINAL ARTICLE. Salvage Surgery After Failure of Nonsurgical Therapy for Carcinoma of the Larynx and Hypopharynx
ORIGINAL ARTICLE Salvage Surgery After Failure of Nonsurgical Therapy for Carcinoma of the Larynx and Hypopharynx Sandro J. Stoeckli, MD; Andreas B. Pawlik, MD; Margareta Lipp, MD; Alexander Huber, MD;
More informationInt J Clin Exp Med 2017;10(1): /ISSN: /IJCEM Jun Lv, Lingjiang Pan, Jiamei Lu, Wen Qin, Tingting Zhang
Int J Clin Exp Med 2017;10(1):1193-1198 www.ijcem.com /ISSN:1940-5901/IJCEM0037899 Original Article Effective radiotherapy dose for suspicious positive cervical lymph nodes for N0 nasopharyngeal carcinoma
More informationManagement of Neck Metastasis from Unknown Primary
Management of Neck Metastasis from Unknown Primary.. Definition Histologic evidence of malignancy in the cervical lymph node (s) with no apparent primary site of original tumour Diagnosis after a thorough
More informationRadiation therapy for locoregionally advanced nasopharyngeal carcinoma in elderly patients
J Radiat Oncol (2012) 1:323 332 DOI 10.1007/s13566-012-0069-0 ORIGINAL RESEARCH Radiation therapy for locoregionally advanced nasopharyngeal carcinoma in elderly patients Qiaojuan Guo & Weiping Jiang &
More informationDepartment of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong.
ORIGINAL ARTICLE PREOPERATIVE MEASUREMENT OF TUMOR THICKNESS OF ORAL TONGUE CARCINOMA WITH INTRAORAL ULTRASONOGRAPHY Anthony Po-Wing Yuen, FHKAM(ORL), Raymond Wai-Man Ng, FHKAM(Plastic), Paul Kin-Yip Lam,
More informationORIGINAL ARTICLE. among populations originating from southern China and their descendants who have emigrated to other parts of the world.
ORIGINAL ARTICLE Prognostic Factors and Outcome for Nasopharyngeal Carcinoma Terence P. Farias, MD; Fernando L. Dias, MD; Roberto A. Lima, MD; Jacob Kligerman, MD; Geraldo M. de Sá, MD; Mauro M. Barbosa,
More informationHead and Neck Reirradiation: Perils and Practice
Head and Neck Reirradiation: Perils and Practice David J. Sher, MD, MPH Department of Radiation Oncology Dana-Farber Cancer Institute/ Brigham and Women s Hospital Conflicts of Interest No conflicts of
More informationRecent advances in the management of nasopharyngeal carcinoma. Citation Hong Kong Practitioner, 1998, v. 20 n. 5, p
Title Recent advances in the management of nasopharyngeal carcinoma Author(s) Wei, WI Citation Hong Kong Practitioner, 1998, v. 20 n. 5, p. 270-281 Issued Date 1998 URL http://hdl.handle.net/10722/53484
More informationLYMPHATIC DRAINAGE IN THE HEAD & NECK
LYMPHATIC DRAINAGE IN THE HEAD & NECK Like other parts of the body, the head and neck contains lymph nodes (commonly called glands). Which form part of the overall Lymphatic Drainage system of the body.
More informationEnterprise Interest None
Enterprise Interest None Cervical Cancer -Management of late stages ESP meeting Bilbao Spain 2018 Dr Mary McCormack PhD FRCR Consultant Clinical Oncologist University College Hospital London On behalf
More informationFate of patients with nasopharyngeal cancer who developed distant metastasis as first failure after definitive radiation therapy
ORIGINAL ARTICLE Fate of patients with nasopharyngeal cancer who developed distant metastasis as first failure after definitive radiation therapy Ji Hyun Chang, MD, 1,3 Yong Chan Ahn, MD, PhD, 1 * Hyojung
More informationCLINICAL OUTCOMES OF 174 NASOPHARYNGEAL CARCINOMA PATIENTS WITH RADIATION-INDUCED TEMPORAL LOBE NECROSIS
doi:10.1016/j.ijrobp.2010.11.070 Int. J. Radiation Oncology Biol. Phys., Vol. 82, No. 1, pp. e57 e65, 2012 Copyright Ó 2012 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/$ - see front
More informationEffect of number and ratio of positive lymph nodes in hypopharyngeal cancer
ORIGINAL ARTICLE Effect of number and ratio of positive lymph nodes in hypopharyngeal cancer Yong-hong Hua, MD, PhD, Qiao-ying Hu, MD, * Yong-feng Piao, MD, Qiu Tang, MD, PhD, Zhen-fu Fu, MD Head and Neck
More informationORIGINAL PAPER. Marginal pulmonary function is associated with poor short- and long-term outcomes in lung cancer surgery
Nagoya J. Med. Sci. 79. 37 ~ 42, 2017 doi:10.18999/nagjms.79.1.37 ORIGINAL PAPER Marginal pulmonary function is associated with poor short- and long-term outcomes in lung cancer surgery Naoki Ozeki, Koji
More informationINTRODUCTION. KEY WORDS: nasopharyngeal carcinoma, recurrence, intensitymodulated radiotherapy (IMRT), endoscopic nasopharyngectomy
ORIGINAL ARTICLE Salvage endoscopic nasopharyngectomy and intensity-modulated radiotherapy versus conventional radiotherapy in treating locally recurrent nasopharyngeal carcinoma Xiong Zou, MD, 1,2 Fei
More informationPeritoneal Involvement in Stage II Colon Cancer
Anatomic Pathology / PERITONEAL INVOLVEMENT IN STAGE II COLON CANCER Peritoneal Involvement in Stage II Colon Cancer A.M. Lennon, MB, MRCPI, H.E. Mulcahy, MD, MRCPI, J.M.P. Hyland, MCh, FRCS, FRCSI, C.
More information4/22/2010. Hakan Korkmaz, MD Assoc. Prof. of Otolaryngology Ankara Dıșkapı Training Hospital-Turkey.
Management of Differentiated Thyroid Cancer: Head Neck Surgeon Perspective Hakan Korkmaz, MD Assoc. Prof. of Otolaryngology Ankara Dıșkapı Training Hospital-Turkey Thyroid gland Small endocrine gland:
More information窑 Original Article 窑. Jun Ma 1,2 鄢. , Zhe Sheng Wen 1,2, Peng Lin 1,2, Xin Wang 1,2, Fang Yun Xie 1,3. 揖 Abstract 铱 Background and Objective: Methods:
窑 Original Article 窑 Chinese Journal of Cancer The results and prognosis of different treatment modalities for solitary metastatic lung tumor from nasopharyngeal carcinoma: a retrospective study of 5 cases
More informationTreatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study
ONCOLOGY LETTERS 10: 3145-3152, 2015 Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study PEIJING LI 1*, WEIHAN HU 1*, YUAN ZHU 2 and JIANJIANG LIU 3 1
More informationPrognostic factors in squamous cell anal cancers
Prognostic factors in squamous cell anal cancers Zainul Abedin Kapacee Year 4-5 Intercalating Medical Student, University of Manchester Dr. Shabbir Susnerwala, Mr. Nigel Scott Dr. Falalu Danwata, Dr. Marcus
More informationFDG-PET/CT in Gynaecologic Cancers
Friday, August 31, 2012 Session 6, 9:00-9:30 FDG-PET/CT in Gynaecologic Cancers (Uterine) cervical cancer Endometrial cancer & Uterine sarcomas Ovarian cancer Little mermaid (Edvard Eriksen 1913) honoring
More informationNasopharyngeal Cancer/Multimodality Treatment
Nasopharyngeal Cancer/Multimodality Treatment PANAGIOTIS KATSAOUNIS Medical Oncologist IASO GENERAL HOSPITAL Athens, 22/10/2016 1 st Hellenic Multidisciplinary Conference on Head and Neck Cancer INTRODUCTION
More informationThe right middle lobe is the smallest lobe in the lung, and
ORIGINAL ARTICLE The Impact of Superior Mediastinal Lymph Node Metastases on Prognosis in Non-small Cell Lung Cancer Located in the Right Middle Lobe Yukinori Sakao, MD, PhD,* Sakae Okumura, MD,* Mun Mingyon,
More informationESMO Preceptorship Program Head & Neck Cancer NPC: Epidemiology, diagnosis and work-up
ESMO Preceptorship Program Head & Neck Cancer NPC: Epidemiology, diagnosis and work-up Dr. John Woo Consultant, ENT Department, PWH Honorary Clinical Professor, Department of Otorhinolaryngology, H&N Surgery
More informationMinimum absolute lymphocyte count during radiotherapy as a new prognostic factor for nasopharyngeal cancer
ORIGINAL ARTICLE Minimum absolute lymphocyte count during radiotherapy as a new prognostic factor for nasopharyngeal cancer Oyeon Cho, MD, Young-Taek Oh, MD, PhD,* Mison Chun, MD, PhD, O-Kyu Noh, MD, PhD,
More informationPlasma EBV DNA Clearance Rate as a Novel Prognostic Marker for Metastatic/Recurrent Nasopharyngeal Carcinoma
Imaging, Diagnosis, Prognosis Plasma EBV DNA Clearance Rate as a Novel Prognostic Marker for Metastatic/Recurrent Nasopharyngeal Carcinoma Clinical Cancer Research Wen-Yi Wang 1, Chih-Wen Twu 2,5, Hsin-Hong
More informationESMO Preceptorship Program Head & Neck Cancer NPC: Epidemiology, diagnosis and work-up
ESMO Preceptorship Program Head & Neck Cancer NPC: Epidemiology, diagnosis and work-up Dr. John Woo Consultant, ENT Department, PWH Honorary Clinical Professor, Department of Otorhinolaryngology, H&N Surgery
More informationLymph node density as an independent prognostic factor in node-positive patients with tonsillar cancer
ORIGINAL ARTICLE Lymph node density as an independent prognostic factor in node-positive patients with tonsillar cancer Jun-Ook Park, MD, PhD, 1 Young-Hoon Joo, MD, PhD, 2 Kwang-Jae Cho, MD, PhD, 2 Min-Sik
More informationLONG-TERM SURGICAL OUTCOMES OF 1018 PATIENTS WITH EARLY STAGE NSCLC IN ACOSOG Z0030 (ALLIANCE) TRIAL
LONG-TERM SURGICAL OUTCOMES OF 1018 PATIENTS WITH EARLY STAGE NSCLC IN ACOSOG Z0030 (ALLIANCE) TRIAL Stacey Su, MD; Walter J. Scott, MD; Mark S. Allen, MD; Gail E. Darling, MD; Paul A. Decker, MS; Robert
More informationBone Metastases in Muscle-Invasive Bladder Cancer
Journal of the Egyptian Nat. Cancer Inst., Vol. 18, No. 3, September: 03-08, 006 AZZA N. TAHER, M.D.* and MAGDY H. KOTB, M.D.** The Departments of Radiation Oncology* and Nuclear Medicine**, National Cancer
More informationReoperative central neck surgery
Reoperative central neck surgery R. Pandev, I. Tersiev, M. Belitova, A. Kouizi, D. Damyanov University Clinic of Surgery, Section Endocrine Surgery University Hospital Queen Johanna ISUL Medical University
More informationPrognostic value of pretreatment and recovery duration of cranial nerve palsy in nasopharyngeal carcinoma
Mo et al. Radiation Oncology 2012, 7:149 RESEARCH Open Access Prognostic value of pretreatment and recovery duration of cranial nerve palsy in nasopharyngeal carcinoma Hao-Yuan Mo 1,2, Rui Sun 1,2, Jian
More informationIDENTIFICATION OF A HIGH-RISK GROUP AMONG PATIENTS WITH ORAL CAVITY SQUAMOUS CELL CARCINOMA AND pt1 2N0 DISEASE
doi:10.1016/j.ijrobp.2010.09.036 Int. J. Radiation Oncology Biol. Phys., Vol. 82, No. 1, pp. 284 290, 2012 Copyright Ó 2012 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/$ - see front
More informationAccepted 28 April 2005 Published online 13 September 2005 in Wiley InterScience ( DOI: /hed.
DEFINING RISK LEVELS IN LOCALLY ADVANCED HEAD AND NECK CANCERS: A COMPARATIVE ANALYSIS OF CONCURRENT POSTOPERATIVE RADIATION PLUS CHEMOTHERAPY TRIALS OF THE EORTC (#22931) AND RTOG (#9501) Jacques Bernier,
More informationClinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer. Cheol Min Kang 2018/04/05
Abstract No.: ABS-0075 Clinicopathological Factors Affecting Distant Metastasis Following Loco-Regional Recurrence of breast cancer 2018/04/05 Cheol Min Kang Department of surgery, University of Ulsan
More informationClinical analysis of 29 cases of nasal mucosal malignant melanoma
1166 Clinical analysis of 29 cases of nasal mucosal malignant melanoma HUANXIN YU and GANG LIU Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China
More informationESMO Perceptorship H&N cancer Epidemiology, Anatomy and Workup 16 March 2018
ESMO Perceptorship H&N cancer Epidemiology, Anatomy and Workup 16 March 2018 Dr. Victor Ho-Fun Lee MBBS, MD, FRCR, FHKCR, FHKAM (Radiology) Clinical Associate Professor Department of Clinical Oncology
More informationIntroduction ORIGINAL RESEARCH
Cancer Medicine ORIGINAL RESEARCH Open Access The effect of radiation therapy in the treatment of adult soft tissue sarcomas of the extremities: a long- term community- based cancer center experience Jeffrey
More informationTsang, RK; Kwong, DL; Ho, AC; To, VS; Ho, WK; Wei, WI
Title Long-term hearing results and otological complications of nasopharyngeal carcinoma patients: comparison between treatment with conventional two-dimensional radiotherapy and intensity-modulated radiotherapy
More informationNICE guideline Published: 10 February 2016 nice.org.uk/guidance/ng36
Cancer of the upper aerodigestive e tract: assessment and management in people aged 16 and over NICE guideline Published: 10 February 2016 nice.org.uk/guidance/ng36 NICE 2018. All rights reserved. Subject
More informationORIGINAL ARTICLE. Harold Lau, MD; Tien Phan, MD; Jack MacKinnon, MD; T. Wayne Matthews, MD
ORIGINAL ARTICLE Absence of Planned Neck Dissection for the N2-N3 Neck After Chemoradiation for Locally Advanced Squamous Cell Carcinoma of the Head and Neck Harold Lau, MD; Tien Phan, MD; Jack MacKinnon,
More informationDr Sneha Shah Tata Memorial Hospital, Mumbai.
Dr Sneha Shah Tata Memorial Hospital, Mumbai. Topics covered Lymphomas including Burkitts Pediatric solid tumors (non CNS) Musculoskeletal Ewings & osteosarcoma. Neuroblastomas Nasopharyngeal carcinomas
More informationOral cavity cancer Post-operative treatment
Oral cavity cancer Post-operative treatment Dr. Christos CHRISTOPOULOS Radiation Oncologist Centre Hospitalier Universitaire (C.H.U.) de Limoges, France Important issues RT -techniques Patient selection
More informationTHE IMPACT OF THE TIME FACTOR ON THE OUTCOME OF A COMBINED TREATMENT OF PATIENTS WITH LARYN- GEAL CANCER
THE IMPACT OF THE TIME FACTOR ON THE OUTCOME OF A COMBINED TREATMENT OF PATIENTS WITH LARYN- GEAL CANCER Piotr Milecki 1, Grażyna Stryczyńska 1, Aleksandra Kruk-Zagajewska 2 Department of Radiotherapy,
More informationMANAGEMENT OF CA HYPOPHARYNX
MANAGEMENT OF CA HYPOPHARYNX GENERAL TREATMENT RECOMMENDATIONS BASED ON HYPOPHARYNX TUMOR STAGE For patients presenting with early-stage definitive radiotherapy alone or voice-preserving surgery are viable
More informationORIGINAL ARTICLE. Management and Outcome of Recurrent Well-Differentiated Thyroid Carcinoma
ORIGINAL ARTICLE Management and Outcome of Recurrent Well-Differentiated Thyroid Carcinoma Carsten E. Palme, MBBS, FRACS; Zeeshan Waseem, BA; S. Naweed Raza, BSc; Spiro Eski, MD; Paul Walfish, MD, FRCPC;
More informationNICE guideline Published: 10 February 2016 nice.org.uk/guidance/ng36
Cancer of the upper aerodigestive e tract: assessment and management in people aged 16 and over NICE guideline Published: 10 February 2016 nice.org.uk/guidance/ng36 NICE 2018. All rights reserved. Subject
More informationLymph node ratio as a prognostic factor in head and neck cancer patients
Chen et al. Radiation Oncology (2015) 10:181 DOI 10.1186/s13014-015-0490-9 RESEARCH Open Access Lymph node ratio as a prognostic factor in head and neck cancer patients Chien-Chih Chen 1*, Jin-Ching Lin
More informationTumor Volume as a Prognostic Factor for Local Control and Overall Survival in Advanced Larynx Cancer
The Laryngoscope VC 2015 The American Laryngological, Rhinological and Otological Society, Inc. Tumor Volume as a Prognostic Factor for Local Control and Overall Survival in Advanced Larynx Cancer Adriana
More informationDefinitive radiotherapy for cervical esophageal cancer
ORIGINAL ARTICLE Definitive radiotherapy for cervical esophageal cancer Caineng Cao, MD, Jingwei Luo, MD, * Li Gao, MD, Guozhen Xu, MD, Junlin Yi, MD, Xiaodong Huang, MD, Kai Wang, MD, Shiping Zhang, MD,
More informationLong-Term Outcomes of Nasopharyngectomy Using Partial Maxillectomy Approach
The Laryngoscope VC 2015 The American Laryngological, Rhinological and Otological Society, Inc. Long-Term Outcomes of Nasopharyngectomy Using Partial Maxillectomy Approach Li Shia Ng, MMed (ORL); Chwee
More informationIndex. Surg Oncol Clin N Am 16 (2007) Note: Page numbers of article titles are in boldface type.
Surg Oncol Clin N Am 16 (2007) 465 469 Index Note: Page numbers of article titles are in boldface type. A Adjuvant therapy, preoperative for gastric cancer, staging and, 339 B Breast cancer, metabolic
More informationOriginal Article. Yuri Jeong, MD 1, Sang-wook Lee, MD, PhD 2. Introduction
Original Article Radiat Oncol J 218;36(4):295-33 https://doi.org/1.3857/roj.218.43 pissn 2234-19 eissn 2234-3156 Tumor volume/metabolic information can improve the prognostication of anatomy based staging
More informationOriginal article: Department of Oncology, Third Affiliated Hospital of Third Military Medical University, Chongqing, China
Original article: THE PREDICTIVE VALUE OF PRE- AND POST-INDUCTION CHEMOTHERAPY PLASMA EBV DNA LEVEL AND TUMOR VOLUME FOR THE RADIOSENSITIVITY OF LOCALLY ADVANCED NASOPHARYNGEAL CARCINOMA Yang Song *, He
More informationRadiotherapy and Conservative Surgery For Merkel Cell Carcinoma - The British Columbia Cancer Agency Experience
Radiotherapy and Conservative Surgery For Merkel Cell Carcinoma - The British Columbia Cancer Agency Experience Poster No.: RO-0003 Congress: RANZCR FRO 2012 Type: Scientific Exhibit Authors: C. Harrington,
More informationTitle. CitationInternational Journal of Clinical Oncology, 20(6): 1. Issue Date Doc URL. Rights. Type. File Information
Title Clinical outcomes of weekly cisplatin chemoradiother Sakashita, Tomohiro; Homma, Akihiro; Hatakeyama, Hir Author(s) Takatsugu; Iizuka, Satoshi; Onimaru, Rikiya; Tsuchiy CitationInternational Journal
More informationRatio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer
Original Article Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer Fangfang Chen 1 *, Yanwen Yao 2 *, Chunyan
More informationClinicopathologic and prognostic factors of young and elderly patients with esophageal adenocarcinoma: is there really a difference?
Diseases of the Esophagus (2008) 21, 596 600 DOI: 10.1111/j.1442-2050.2008.00817.x Original article Clinicopathologic and prognostic factors of young and elderly patients with esophageal adenocarcinoma:
More informationPET imaging of cancer metabolism is commonly performed with F18
PCRI Insights, August 2012, Vol. 15: No. 3 Carbon-11-Acetate PET/CT Imaging in Prostate Cancer Fabio Almeida, M.D. Medical Director, Arizona Molecular Imaging Center - Phoenix PET imaging of cancer metabolism
More informationClinical Study Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma
BioMed Research International Volume 2015, Article ID 617949, 5 pages http://dx.doi.org/10.1155/2015/617949 Clinical Study Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally
More informationBest Papers. F. Fusco
Best Papers UROLOGY F. Fusco Best papers - 2015 RP/RT Oncological outcomes RP/RT IN ct3 Utilization trends RP/RT Complications Evolving role of elnd /Salvage LND This cohort reflects the current clinical
More informationEsophageal cancer is a significant health hazard for
Postoperative Radiotherapy Improved Survival of Poor Prognostic Squamous Cell Carcinoma Esophagus GENERAL THORACIC Junqiang Chen, MD, Ji Zhu, MD, Jianji Pan, MD, Kunshou Zhu, MD, Xiongwei Zheng, MD, Mingqiang
More informationReirradiation with intensity-modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma
ORIGINAL ARTICLE Reirradiation with intensity-modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma Oscar S. H. Chan, FRCR, 1 Henry C. K. Sze, FRCR, 1 Michael C. H. Lee, PhD, 2
More informationXiang Hu*, Liang Cao*, Yi Yu. Introduction
Original Article Prognostic prediction in gastric cancer patients without serosal invasion: comparative study between UICC 7 th edition and JCGS 13 th edition N-classification systems Xiang Hu*, Liang
More informationClinical Management Guideline for Small Cell Lung Cancer
Diagnosis and Staging: Key Points 1. Ensure a CT scan that is
More informationADJUVANT CHEMOTHERAPY...
Colorectal Pathway Board: Non-Surgical Oncology Guidelines October 2015 Organization» Table of Contents ADJUVANT CHEMOTHERAPY... 2 DUKES C/ TNM STAGE 3... 2 DUKES B/ TNM STAGE 2... 3 LOCALLY ADVANCED
More informationARTICLE IN PRESS. doi: /j.ijrobp METAPLASTIC CARCINOMA OF THE BREAST: A RETROSPECTIVE REVIEW
doi:10.1016/j.ijrobp.2005.08.024 Int. J. Radiation Oncology Biol. Phys., Vol. xx, No. x, pp. xxx, 2005 Copyright 2005 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/05/$ see front matter
More informationAccepted 19 May 2008 Published online 2 September 2008 in Wiley InterScience (www.interscience.wiley.com). DOI: /hed.20912
ORIGINAL ARTICLE OUTCOMES FOLLOWING PAROTIDECTOMY FOR METASTATIC SQUAMOUS CELL CARCINOMA WITH MICROSCOPIC RESIDUAL DISEASE: IMPLICATIONS FOR FACIAL NERVE PRESERVATION N. Gopalakrishna Iyer, MBBS (Hons),
More informationFailure patterns and factors affecting prognosis of salivary gland carcinoma: retrospective study
Failure patterns and factors affecting prognosis of salivary gland carcinoma: retrospective study PML Teo, ATC Chan, WY Lee, SF Leung, ESY Chan, CO Mok Salivary gland carcinoma Objectives. To investigate
More informationRADIO- AND RADIOCHEMOTHERAPY OF HEAD AND NECK TUMORS. Zoltán Takácsi-Nagy PhD Department of Radiotherapy National Institute of Oncology, Budapest 1.
RADIO- AND RADIOCHEMOTHERAPY OF HEAD AND NECK TUMORS Zoltán Takácsi-Nagy PhD Department of Radiotherapy National Institute of Oncology, Budapest 1. 550 000 NEW PATIENTS/YEAR WITH HEAD AND NECK CANCER ALL
More informationWhen to Integrate Surgery for Metatstatic Urothelial Cancers
When to Integrate Surgery for Metatstatic Urothelial Cancers Wade J. Sexton, M.D. Senior Member and Professor Department of Genitourinary Oncology Moffitt Cancer Center Case Presentation #1 67 yo male
More informationDoppler ultrasound of the abdomen and pelvis, and color Doppler
- - - - - - - - - - - - - Testicular tumors are rare in children. They account for only 1% of all pediatric solid tumors and 3% of all testicular tumors [1,2]. The annual incidence of testicular tumors
More informationAdjuvant Therapy in Locally Advanced Head and Neck Cancer. Ezra EW Cohen University of Chicago. Financial Support
Adjuvant Therapy in Locally Advanced Head and Neck Cancer Ezra EW Cohen University of Chicago Financial Support This program is made possible by an educational grant from Eli Lilly Oncology, who had no
More informationBone and CT Scans Are Complementary for Diagnoses of Bone Metastases in Breast Cancer When PET Scans Findings Are Equivocal: A Case Report
Bone and CT Scans Are Complementary for Diagnoses of Bone Metastases in Breast Cancer When Scans Findings Are Equivocal: A Case Report Yuk-Wah Tsang 1, Jyh-Gang Leu 2, Yen-Kung Chen 3, Kwan-Hwa Chi 1,4
More informationPre- Versus Post-operative Radiotherapy
Postoperative Radiation and Chemoradiation: Indications and Optimization of Practice Dislosures Clinical trial support from Genentech Inc. Sue S. Yom, MD, PhD Associate Professor UCSF Radiation Oncology
More informationINTRODUCTION. Cancer Res Treat. 2008;40(4):
Cancer Res Treat. 2008;40(4):155-16 Radiation Therapy Combined with (or without) Cisplatin-based Chemotherapy for Patients with Nasopharyngeal Cancer: 15-years Experience of a Single Institution in Korea
More informationGUIDELINES ON PROSTATE CANCER
10 G. Aus (chairman), C. Abbou, M. Bolla, A. Heidenreich, H-P. Schmid, H. van Poppel, J. Wolff, F. Zattoni Eur Urol 2001;40:97-101 Introduction Cancer of the prostate is now recognized as one of the principal
More information290 Clin Oncol Cancer Res (2009) 6: DOI /s
290 Clin Oncol Cancer Res (2009) 6: 290-295 DOI 10.1007/s11805-009-0290-9 Analysis of Prognostic Factors of Esophageal and Gastric Cardiac Carcinoma Patients after Radical Surgery Using Cox Proportional
More informationRevisit of Primary Malignant Neoplasms of the Trachea: Clinical Characteristics and Survival Analysis
Jpn J Clin Oncol 1997;27(5)305 309 Revisit of Primary Malignant Neoplasms of the Trachea: Clinical Characteristics and Survival Analysis -, -, - - 1 Chest Department and 2 Section of Thoracic Surgery,
More informationGuideline for the Management of Vulval Cancer
Version History Guideline for the Management of Vulval Cancer Version Date Brief Summary of Change Issued 2.0 20.02.08 Endorsed by the Governance Committee 2.1 19.11.10 Circulated at NSSG meeting 2.2 13.04.11
More informationAfter primary tumor treatment, 30% of patients with malignant
ESTS METASTASECTOMY SUPPLEMENT Alberto Oliaro, MD, Pier L. Filosso, MD, Maria C. Bruna, MD, Claudio Mossetti, MD, and Enrico Ruffini, MD Abstract: After primary tumor treatment, 30% of patients with malignant
More information