A Never Obsolete Face and Body Platform

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Loren Johnston
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2 A Never Obsolete Face and Body Platform Obsolescence is one of the major problems in technology: The need to purchase the latest piece of equipment is the recurring complaint of physicians worldwide. What if medical technology were built to evolve instead? That s the thinking behind Coaxmed, a modular, upgradable face and body platform developed by Biotec Italia. Maximize your investment while minimizing cost Physicians today need cost effective medical technology. Coaxmed is a state-of-the-art face and body system that was designed as an upgradable platform with the ability to be upgraded to the latest innovations and technologies in the market without the need of purchasing a new model. The results Elimination of cellulite and localized adiposity Reduction of wrinkles and fine lines Improvement of acne and enlarged pores Skin tightening Long-term new collagen synthesis No patient recovery time Coaxmed is a unique technological innovation, combining several technologies into one safe and non-invasive system for body and facial procedures. This combination is the key to an amazing increase in the quality of the aesthetic results. Coaxmed is therefore a technological platform that guarantees absolute efficacy of the treatments: a real generator of beauty and well-being with a unique and exclusive design. Unique treatment protocols have been developed by Biotec Italia experts in order to maximize the effect of each treatment. Coaxmed identifies the various treatments depending on the body area (face, stomach, buttocks, legs), thus enabling intervention on specific areas with different treatment combinations. The Innovation A complete method Uniqueness of treatment procedures Reliability of the technology Constant upgrade of Coaxmed technology Integration of products and services Marketing communication

Device Overview Radiofrequency monopolar, bipolar and tripolar Microneedling Fractional Radiofrequency Combined Low Frequency Ultrasound and Radiofrequency Rhythmic vacuum Coolshape Coaxmed consists

Coaxmed system, compared to other Radiofrequency or Cavitation devices is extremely versatile, due to a very sophisticated software.

3 Device Overview Radiofrequency monopolar, bipolar and tripolar Microneedling Fractional Radiofrequency Combined Low Frequency Ultrasound and Radiofrequency Rhythmic vacuum Coolshape Coaxmed consists of a 350-watt Radiofrequency generator that operates in a frequency ranging from 300 KHz up to 1 MHz and a 28 KHz Ultrasound generator. Coaxmed system, compared to other Radiofrequency or Cavitation devices is extremely versatile, due to a very sophisticated software. By modifying the RF frequency it is possible to selectively develop heat at different tissue depths. At the same time the RF pulse can be modified, through the RF modulation (RFM), to boost patient s tolerance to the treatment by pausing the RF emission. Rhythmic vacuum smooths out the skin to facilitate safe and efficient heat energy delivery, while a thermo-electric coupling tip cooler protects the epidermis. Furthermore a cup-like applicator can be placed directly on the desired area to cool down the fat tissue to near-freezing temperatures. This results in fat layer reduction; the treated fat cells will be then flushed out of the body naturally.

Multiple facial technologies Fractional Radiofrequency The procedure features the combination of radiofrequency, microneedling and vacuum to generate changes in the structure of the dermis to treat

Less painful and more accurate than the traditional skin needling roller, the microscopic punctures stimulate collagen production in the dermis layer as it breaks some of the blood vessels directly

Radiofrequency monopolar and bipolar The RF (radiofrequency) generator produces a signal of radiofrequency from 300 KHz to 1 MHz, controlled by a microprocessor which receives information concerning

4 Multiple facial technologies Fractional Radiofrequency The procedure features the combination of radiofrequency, microneedling and vacuum to generate changes in the structure of the dermis to treat superficial and deep wrinkles and to fight skin laxity. Less painful and more accurate than the traditional skin needling roller, the microscopic punctures stimulate collagen production in the dermis layer as it breaks some of the blood vessels directly below the surface of the skin while the untreated tissue that acts as a ''free'' biological reserve grants a quick recovery and the absence of side effects. Radiofrequency monopolar and bipolar The RF (radiofrequency) generator produces a signal of radiofrequency from 300 KHz to 1 MHz, controlled by a microprocessor which receives information concerning the temperature, and the energy used when in contact with the skin. The face handpiece emits monopolar or bipolar radio frequency which can be combined with rhythmic vacuum, and creates an even heating, hence stimulating contraction and regeneration of collagen fibers. Combined bipolar radiofrequency and rhytimic vacuum Utilizes the principles of changing air pressure which stimulates the blood circulation, thus facilitating drainage, to reduce under eyes puffiness and improve all the radiofrequency effects. Indications Superficial and deep wrinkles Sun damaged skin Small wrinkles Acne and skin impurities Enlarged pores Rough and thickened skin Hyperpigmentation marks Stretch marks Acne scars

$Skin Tite In this application, microneedles penetrate into the skin (penetration depth is adjustable according to needle s lenght). Microfractional holes are created on epidermis and dermis.$

5 Skin Tite In this application, microneedles penetrate into the skin (penetration depth is adjustable according to needle s lenght). Microfractional holes are created on epidermis and dermis. Monopolar radiofrequency is emitted in deep dermis, inducing dermal coagulation. The fractional radiofrequency heats up the deeper dermis in 360 degrees around each microneedle tip for further collagen tightening and synthesis. RF Shape Monopolar or unipolar facial radiofrequency refers to the RF being delivered by one pole or electrode on the applicator. Heating affects the superficial and deep tissue. In the monopolar application, a grounding or return pad is used, placed on the patient s lower back. Bipolar refers to two poles or electrodes on the applicator. To facilate safe and effective heat energy delivery a thermo-electric coupling tip cooler protects the epidermis. Bipolar RF Shape With bipolar delivery the current flows through the tissue which is between the two electrodes on the applicator. Heating affects the superficial tissue only. It can be combined with Rhytmic vacuum.

Multiple Body and Lipo technologies Combined Low Frequency Ultrasound and Radiofrequency The combined ultrasound and radiofrequency procedure alleviates cellulite symptoms and melts fat by means of

6 Multiple Body and Lipo technologies Combined Low Frequency Ultrasound and Radiofrequency The combined ultrasound and radiofrequency procedure alleviates cellulite symptoms and melts fat by means of several mechanisms: cellular and fibrosis disruption due to ultrasonic cavitation; dermal tightening of fibrous filaments due to thermal injury affecting the network of blood vessels, which triggers a cascade of inflammatory events, including fibroblast proliferation and apparent up-regulation of collagen formation; enhancement of local blood circulation (vasodilation and hyperemia) and drainage of fatty deposits to the lymphatic system; fat cell disintegration and thermal-induced fat cell apoptosis. Monopolar radiofrequency Monopolar radiofrequency technology delivers heat creating a stronger, more accurately distributed thermal response throughout all skin layers. The result is a minimized appearance of lumpy skin, tissue tightening, fat shrinkage, improved skin texture and a visible reduction in circumference. Combined laser, Cryo and rhytmic vacuum Equipped with three different technologies, the Vaculase laser handpiece combines 4 diode lasers (wavelength 810 nm) with contact cooling and mechanical aspiration-massage. The rhythmic massage distends the skin and fibrous septal bands to enhance microcirculation, which increases skin elasticity and promote lymphatic drainage. The diode lasers stimulate dermal fibroblasts to produce collagen, creating a smoother skin appearance. Indications Excess fat Cellulite Pre and post-liposuction Body smoothing Skin firming proprietary technology Easy-Plug connector Water - Air - Data signal - Power signal

7 DuoShape Unique simultaneous emission of high-power radiofrequency and high-power cavitational ultrasound. Low frequency ultrasound destroys fat cell membranes thanks to the so called cavitational effect. Monopolar radiofrequency: electrical currents within a frequency range of 300KHz to 1MHz intensively heat the dermis and the hypodermis to shrink the existing collagen fiber network. Both ultrasound and radiofrequency currents enhance the absorption of active ingredients through the skin. VACUUM Vaculase and Lipomassage Phase 1: Deep Laser Stimulation The laser diodes reactivate and boosts the arterial, venous and lymphatic micro- circulation, encouraging neoangiogenesis of the intradermal vessels. The laser light energy also has beneficial effects on fibroblast activity. Phase 2: Localised Cooling The localised cooling system boosts the volume-reducing effect, optimising reabsorption of the edema by stimulating vascular workout. Phase 3: Lipomassage The rhythmic aspiration massage stimulates the lympho-drainage and tissue stimulation processes, enhancing restoration of the skin s normal collagen elastic tension. Coolshape The cells in our body react to heat or cold at different temperature levels. During the Coolshape procedure, the sophisticated device s applicator is pressed against the area to be treated thanks to the simultaneous action of vacuum aspiration. The intense cooling effect (-10º) is able to target only the fat cells in that area. After the procedure the fat cells begin a process called apoptosis, which brings them to a natural physiological death. At this stage the body reacts with an inflammatory response that causes the natural disposal of the damaged fat cells. The procedure allows a significant improvement in the shape of the treated area.

8 Combo: Dual Treatment Technology Sculpt Face and Body at the same time A truly Revolutionary Treatment Method. Contouring the face while effectively reducing excess localized fat with Cryoliposculpt is now possible! One Solution for Face and Body Achieve More Results in Less Time Increase Potential Revenues and Improve your Reputation Combined Application of Face and Body Procedure More Treatment in One Session Increases Appointment Bookings

9 Facial Body Scientific Publications Mala Bhalla et al. dermatologic Surgery 2006; 32: Mohamed L. Elsaie et al. Dermatologic Surgery 2009; 35: Joseph F. Sobanko et al. Dermatologic Surgery 2008; 37: 46. Pereira AN et al. Lasers in Surgery and Medicine 2002; 31: 263. Medrado AR et al. Lasers in Surgery and Medicine 2003; 32: 239. Almeida-Lopes L. et al. Lasers in Surgery and Medicine 2001; 29: 179. A. Tülin Güleç, International Journal of Dermatology 2009, 48, W.I. Worret, JEADV 2004, 18, Woan-Ruoh Lee et al. Lasers in Surgery and Medicine 2008, 40: J. Gehl, Acta Physiol Scand 2003, 177, Lei Zhang et al. Bioelectrochemistry and Bioenergetics 1999; 48:

Radiofrequency Function Monopolar/Bipolar/Tripolar Frequency from 300KHz up to 1MHz Power 130 W (max) Cryo up to -10

6KPa (Max) Mode Continuous/pulsed COOLSHAPE AVAILABLE APPLICATORS Vaculase Led Laser Max Power: 1W continous Led Laser: 4

Hz Power 450 W (max) Class IIB Dimensions 320(H) x 460(W) x 540(D) mm Duo Medium Medium Large to treat two areas

10 Radiofrequency Function Monopolar/Bipolar/Tripolar Frequency from 300KHz up to 1MHz Power 130 W (max) Cryo up to -10 Ultrasounds Frequency 28 Khz Power 130 W (max) Vacuum Suction 66.6KPa (Max) Mode Continuous/pulsed COOLSHAPE AVAILABLE APPLICATORS Vaculase Led Laser Max Power: 1W continous Led Laser: 4 Suction: 66,6kPa Cooling: 5 C (max) General Features Treatment ignition Switch on the monitor Power Rate Vac 50/60 Hz Power 450 W (max) Class IIB Dimensions 320(H) x 460(W) x 540(D) mm Duo Medium Medium Large to treat two areas simultaneously 148mm 200mm CERTIFIED BiotecItalia srl Viale della Repubblica Dueville (Vicenza) tel. +39 (0) fax +39 (0) info@biotecitalia.com

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