Ophthalmology. Instruments Surgicals Consumables. High Performance Products for Ophthalmologists

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1 Ophthalmology Instruments Surgicals Consumables 2018 High Performance Products for Ophthalmologists

2 About us Iso Clear is a wholly-owned South African company supplying high quality, affordable ophthalmology products and solutions into the market, with superior levels of customer service and intimacy. We hold distributor rights in South Africa - and in some cases Africa - for a range of ophthalmology devices, surgicals and surgical consumables. We partner only with reputable and ethical international and local manufacturers. Superior customer service Value Proposition The Iso Clear philosophy is Superior Customer Service. Quality. Innovation. We understand that our customers want quality products that are reliably available and are within budget. Our approach is to source or manufacture products that satisfy the purchase criteria of our customers as well as the user requirements of the end-users, the ophthalmic surgeons. All new products are formally evaluated by our dedicated Clinical Committee of ophthalmic surgeons, before being adopted into the Iso Clear product range. Quality of products All products in our range have been designed and manufactured under a comprehensive quality management system for medical devices, and carry either the CE Mark or are FDA approved. Certificates of Quality can be produced upon request for all our products. Quality Innovation Quality Management System Iso Clear itself will imminently be an ISO accredited firm, which means that we satisfy the requirements for a quality management system that can demonstrate our ability to provide medical devices and related services that consistently meet customer and applicable regulatory requirements.

3 Brands and Suppliers We are proud to partner with reputable international and local manufacturers and suppliers, which allows us to offer well-recognised, quality products and brands. These are some of our partners and the products we have access to: Our Partners & Suppliers Products Single-use knives, e.g. diamond knives. Refer also Accumtome catalogue. Surgical cleaning eye wipes. IOL injector systems; Irrigation/aspiration phaco handpiece. Ophthalmic drapes. Surgical latex gloves. Vitreoretinal surgical products: e.g. Laser & LED light source machines; Laser probes; Endo illuminator probes Viscosurgical devices; Cross-linking solutions; Ophthalmic dyes; Lubricating eye drops; Retinal stabilising adjuncts; Corneal protection. Micro-surgical instruments; Various consumables. Refer also Rumex catalogue. Scleral markers; Retrobulbar needles; Lachrymal needles; Viscuous fluid injection cannulas. Disposable (single-use) ophthalmic knives; Eye shields; 26 g lachrymal cannulas. Rycroft cannulas; Hydrodissection cannulas; Instrument wipes; Punctum plugs; Various consumables. Refer also Tecfen catalogue. Surgical markers. Intra-Ocular Lenses; Viscoelastics.

4 Contents Contents Page Link Ophthalmic Knives/Blades 5 Phaco Instruments/Accessories 6 Vitreoretinal instruments/accessories 7 Laser and Light (LED) Sources (Retinal Probes & Illuminators) 8 Cannulas and Needles 9 Microkeratome Blades and Tubing 12 Intraocular Lenses & Injectors 13 Surgical Consumables and Other 14 Ophthalmic Viscosurgical Devices 14 Corneal Collagen Cross-Linking Solutions 15 Corneal Epithelium Protection 16 Ophthalmic Surgical Dyes 16 Lubricating Eye Drops 17 Other 18 Ophthalmic and Lasik Drapes 20 Surgical Gloves (Latex, powder-free) 21 Appendix A: Summarised Listing of Iso Clear Products 23 Please note: The items listed in this catalogue are typically kept in stock by Iso Clear. We have distributor access to a wider range of ophthalmic surgical instruments and consumables through, for instance through Rumex, Accutome and Tecfen. Their catalogues can be viewed via these website links: On-line catalogue Downloadable pdf catalogue Rumex Website PDF file Accutome Website PDF file Tecfen Website PDF file

5 Ophthalmic Knives/Blades 5 A range of single-use ophthalmic surgical cutting instruments. Stab Knives and Collets 15, 22.5, 30, 45 (Knives). 15 (Collet) # Strong, true point for easy penetration during initial stab incision Nappi code: (15 knife) Crescent 2.0mm Knife or Collet Angled Bevel Up # Smooth scleral shelf to promote a self-sealing wound Minimal tissue drag and distortion. Bevel to compensate for curvature Nappi code: Crescent 2.0mm Knife or Collet Straight # Smooth scleral shelf to promote a self-sealing wound. Minimal tissue drag and distortion Nappi code: Phaco Slit Single Bevel Knife Angled 1.8mm; 2.0mm; 2.1mm; 2.2mm; 2.3mm; 2.4mm; 2.5mm; 2.65mm; 2.75mm; 2.8mm; 2.85mm; 3.0mm; 3.2mm; 3.5mm # Precision slit knives penetrate easily while creating an accurate width incision for optimal fit to the phacoemulsification tip Nappi code: (3.0mm) MVR/Sideport Knives Straight or Angled 0.9mm (20G); 1.1mm (19G); 0.6mm (23G); 0.8mm (21G); 0.5mm (25G) # MVR / Sideport Knife - side cutting ability Nappi code: (0.9mm (20G) Straight)

6 Phaco Instruments/Accessories 6 A range of single-use and re-sterilisable ophthalmic surgical instruments for phaco and anterior procedures. I/A Handpiece # G Coaxial Aspiration cannula angled 45 for incisions of 2.5mm Polished head Nappi code: Phaco Tip Hypersonic 30 19/20G # Made of high grade titanium. High-polish finish. Wide range of tip sizes and designs available Compatible with the majority of equipment and to cover traditional and bi-manual and coaxial microincision techniques Nappi code: Tip-Wrench (non-sterile) # Stainless-steel Precise and efficient tightening and unscrewing of the tips Nappi code: N.A. Sleeve 19G Blue Coolflow (non-sterile) # Available for 19G, 20G, 21G and 23G phaco tips For incisions of 2.8 mm to sub 2.00 mm Nappi code: Test Chamber Silicone (non-sterile) # Filled with irrigating solution Nappi code:

7 Vitreoretinal Instruments/Surgicals 7 A range of single-use and re-sterilisable ophthalmic instruments for vitreoretinal and posterior procedures. One Step Trocar 23G # Trocar knife with preloaded trocar cannula 3 pieces Self-sealing trocar cannula; 3 pieces; Infusion line 1 piece; 5 sets per box; Disposable Nappi code: TBA Illuminated Endolaser Probe Curved or Straight 20G, 23G, 25G, 27G # a/b/c/d/e/f/g/h Nappi code: TBA Endolaser Probe 23G Curved or Straight 20G, 23G, 25G, 27G # a/b/c/d/e/f/g/h Nappi code: TBA Endoillumination Probe: Light Pipe or Wide Angle or Shielded 20G, 23G, 25G, 27G # a/b/c/d/e/f/g/h Nappi code: TBA Chandelier 23G, 25G, 27G (double) Nappi code: TBA

8 Laser and Light/LED Sources 8 A range of compact machines for endolaser photocoagulation and ophthalmic LED light source. Fenix in-1 endolaser photocoagulation and ophthalmic LED light source. # Compact green endolaser photocoagulation. New generation laser Thin-Disk technology. Highest beam quality. Quick power stabilisation in the ms-impulse regime. No peaks visible even in the on-off phase of the pulse. Programmable, userfriendly touchscreen menu. Maximum 3 watts power. LIO and SLT compatible. Compatible with 20G, 23G, 25G and 27G standard and illuminated Fenix endolaser probes Ledix Ophthalmic LED Light Source # Port illumination output. User-friendly touchscreen menu. No IR or UV. 50,000 hours lifetime. Real white light. Compatible with different tips of 20G, 23G, 25G and 27G chandeliers, illuminators & illuminated endolaser probes Specifications Laser source Laser wavelength Laser power Duration- interval pulse time Laser aiming beam Laser cooling Delivery system Integrated Light source Led safety Led cooling Size dimensions Weight Input power Optional accessories High Technology THINDISC efficiency laser 532 nm green laser 3000 mw high power laser. Software limited 1500mw for safety and longer lifetime 10ms to 3000ms 640 nm visible low power laser(10mw max) Air - tec cooling system with silent fan With special Fenix endolaser probe connection High power cool white led Temperature-controlled for longer lifetime Silent fan cooling 310 mm x 120 mm x mm (width x height x depth) 4.6 kg Volt AC 50/60 Hz T 2.0 A fused SLT and LIO adaptors

9 Cannulas and Needles 9 A range of Cannula products, including: Anterior Chamber Irrigation, Anterior Chamber Maintenance, Capsule Polishing; Capsulotomy; Cortex Removal; Hydrodissection; Irrigation & Air Injection; Irrigation & Aspiration; Nucleus Removal. Other types and dimensions are available, the following products are popular items. Handle Backflush # For passive aspiration With finger control and luer lock cannula connection Nappi code: Cannula Backflush # G Extrusion Cannula for Passive Aspiration during Vitrectomy procedure Nappi code: Cannula Straight Soft Tip # Soft tip for Vitreoretinal handpieces Silicone extends to 1mm beyond end of cannula Nappi code:

10 Cannulas and Needles 10 Cannula Lacrimal 26g, curved # For insertion and irrigation of the nasolacrimal system Nappi code: Anterior Chamber Cannula 27g 5mm bend # Nappi code: Anterior Chamber Cannula 25g 5mm bend # Nappi code: For maintaining the anterior chamber during surgery and keeping the cornea moist. For use to inject BSS, viscoleastics, Air or intraocular medication Capsulorhexis Cystotome 27g # Angled tip for push or pull cutting during CCC (Continuous Curvilinear Capsulotomies). Nappi code: Standard Retrobulbar Needle 25G x 11/2" (0.5x38mm) # For injecting anaesthetic into the sub tenon space and around the globe Nappi code: Hydrodissection Cannula [Kellan] 27g x 22mm (7/8") curved # For separating posterior capsule and cortical attachments Smooth insertion and permits fanlike distribution of fluid for easier separation Kellan (Vertical plane) Nappi code:

11 Cannulas and Needles 11 Cannula Hydrodissection J-Shaped 25G/27G vertical flat tip # For separating posterior capsule and cortical attachments J-shaped flattened tip provides hydrodissection between the 10- & 12 o'clock position Nappi code: (25G) Cannula Anterior Chamber Maintainer 20G/23G Ribbed Open tip 20G/27G Smooth Tip # For maintaining & forming the anterior chamber during surgery by injecting or removing viscoelastic materials, BSS or air Nappi code: (20G Ribbed) Sub Tenon 19g 25mm x 1" curved flattened tip # Nappi Code:

12 Microkeratome Blades & Tubing 12 Mickrokeratome Blades # Compatibility: Zyoptix XP, Hansatome, Moria QE101 is Compatible Nappi code: Tubing Tubing contains proper Keratome fittings with a moisture trap. Precision filter designed to capture moisture before it damages the Microkeratome console, increasing the lifespan of the device All tubing both sterile and disposable. # Moria Compatible # Hansatome compatible Nappi code:

13 Intraocular Lenses & Injectors 13 IOLs and Lens Injector Systems Acriva : Our premium, yet well-priced, monofocal IOL from Dutch-based VSY Biotechnology. Iso Clear is listed on Discovery Health s approved supplier list of Monofocal and Toric IOLs. IOLs and Lens Injector Systems Intraocular Lens #UD 008ACR30 Diopter Sizes +3.0 to Produced from an ultra pure acrylate monomer, selected for its 25% water content along with its water resistant hydrophobic surface UD Aspheric, Copolymer-Hydrophobic Surface, UV Filter, 13.0 mm diameter. Modified C haptic Nappi code: Contact Iso Clear Viscoject-Bio 2.7 Injector set Viscoject eco Injector-Set 2.7 for 1-piece lenses. Box of 20 # For incision sizes of sub 2.8 mm Nappi code: N.A. # For incision sizes of sub 2.2 mm Nappi code: N.A.

14 Surgical Consumables 14 A range of biotechnology products and solutions for ophthalmology: Ophthalmic Viscosurgical Devices; Corneal Epithelium Protection; Crosslinking Solutions; Ophthalmic Dyes; Eye Drops. Ophthalmic Viscosurgical Devices Viscoelastic solutions for intraocular injection, used to make cataract surgery safer and easier by maintaining the deep anterior chamber, protecting ocular structures, and reduced trauma to the corneal endothelium and other ocular tissues. The viscoelastics are manufactured from purified sodium hyaluronate of high molecular mass, dissolved in a physiological buffer. A clear, sterile, non-pyrogenic, viscoelastic solution. Protectalon Cohesive 1.0%, 1.2%, 1.4%, 1.6%, 1.8%, 2.0% # a/b/c/d/e/f Supplied prefilled in glass syringes with 25g, bent tip, blunt cannula 1.1 ml syringe of 10mg, 12mg, 14mg, 16mg, 18mg or 20mg per ml sodium hyaluronate dissolved in physiological buffer Nappi code: /001 (1.0% variant) Protectalon Dispersive 3.0% # Supplied prefilled in glass syringes with 25 g, bent tip, blunt cannula 1.1 ml syringe of 30mg/ml sodium hyaluronate sodium hyaluronate. Dissolved in physiological buffer Nappi code: / % Cohesive displayed

15 Surgical Consumables 15 Corneal Collagen Cross-Linking Solutions A range of Riboflavin (vitamin B2) solutions, used with UV-A light as a corneal collagen cross-linking surgical treatment for corneal ectasia such as keratoconus, PMD, and post-lasik ectasia. Applied to cornea to facilitate performance of ophthalmic crosslinking procedures using UV light to treat corneal disorders. Riboflavin solution acts as photosensitizing agent that releases free radicals (reactive oxygen) that result in cross-link formation on the collagen chains. Also protects the cornea from UV during procedure. Ribotran # Standard Riboflavin Isotonic Solution with Dextran for epi-off procedures 1 preloaded glass syringe, 3.0ml Riboflavin (0.1%), Dextran (20%) Nappi code: Ribotran Iso (for epi-off) # preloaded glass syringe, 3.0ml. Riboflavin (0.1%), HPMC (1.0%) Nappi code: Ribotran Hypo (for corneal swelling) # Hypotonic solution for corneal swelling. If corneal thickness is under 370 μm, corneal thickness must be increased by means of Ribotran-hypo to ensure endothelial safety 1 preloaded glass syringe, 2.0ml Riboflavin (0.1%) Nappi code: Ribotran TE (for epi-on) # Transepithelial solution for epi-on procedures No removal of corneal epithelium necessary 1 preloaded glass syringe, 2.0ml Riboflavin (0.25%), HPMC (1.0%), BAC (0.007%) Nappi code:

16 Surgical Consumables 16 Corneal Epithelium Protection Ophthalmic solution to hydrate and protect the cornea during ophthalmic procedures. This ophthalmic solution eliminates the need for frequent interruptions to irrigate with BSS because of the longer hydration duration provided by this product. It advances comfort during surgery. This ophthalmic solution also protects the corneal epithelium from being injured, which commonly occurs when using BSS. VisiProtect # A sterile, pyrogen free, viscoelastic solution of highly purified, non-inflammatory hydroxypropyl methylcellulose (HPMC) solution A prefilled glass syringe (2ml) and one sterile cannula for single use Hypromellose (2%), Sodium Chloride, Phosphate buffered saline Nappi code: Ophthalmic Surgical Dyes for Vitreous and Membranes Trypan blue (stains the anterior capsule and fibrous tissue) and Brilliant blue (stains of the Inner Limiting Membrane (ILM) and epiretinal membranes). TryBlue-S # A sterile, pyrogen-free solution. 1 preloaded glass syringe, 2.0ml and one sterile cannula for single use Tryphan Blue (0.10 %), Sodium Chloride, Mannitol, Phosphate Buffered Saline, Aqua Nappi code: DuoBlue # A sterile, pyrogen-free solution. 1 preloaded glass syringe, 2.0ml and one sterile cannula for single use Tryphan Blue (0.1 %), Brilliant Blue (0.05 %), Sodium Chloride, Mannitol, Phosphate Buffered Saline, Aqua Nappi code:

17 Surgical Consumables 17 Lubricating Eye Drops Solutions that lubricate and moisten the delicate tissue of the eye, with unique combinations of ingredients that coats and re-coats the surface of the eye for continued relief of dry, irritated eyes. Contain no damaging chemicals, and provides instant and continued comfort with fewer applications required. VisiTears # Indications: Irritated eyes; Burning, itching eyes; Tired eyes; Morning dry eyes; End-of-day dry eyes; Night-time dry eyes; Discomfort and vision problems related to Computer Vision Syndrome Supplied prefilled in a white dropper bottle (15 ml) Sodium carboxymethylcellulose (0.5%), Glycerine, Sodium Chloride, Phosphate Buffered Saline, Aqua, SOC as preservative. Nappi code: VisiTears Ultra # For relief and protection from dry eye symptoms Supplied prefilled in a green dropper bottle (10ml) Sodium Hyaluronate (0.1%), Sodium carboxymethylcellulose (0.5%), Glycerine, Erythritol, Phosphate Buffered Saline and SOC as preservative. Nappi code: /001

18 Surgical Consumables 18 Other Consumables Instrument Wipe 7.6cm x 7.6cm x 1mm # Pack with 20/box Sterile Nappi code: Blefavis Cleansing Wipes # Cleaning and disinfectan wipes for the eye zone An innovative product made by soaked wipes in liquid specifically designed for the daily cleaning of the sensitive and seborrheic eyelids and eyelashenappi code: Eye Shields Clear Sterile # Lightweight polycarbonate shields for post-operative use Nappi code: Spears surgical PVA lint free # Sterile, Lint free and super absorbent Nappi code: Bio Glo Fluerecein Sodium # Fluorescein Sodium Stips(100/box) for Dry Eye Diagnostics Nappi code: Sterile pre-loaded punctum plugs 0.7mm; 0.8mm; 0.9mm # ; # ; # Nappi code: ; ; Longterm relief from dry-eye syndrome.inserted into punctal opening to block tear drainage through the canaliculus.

19 Surgical Consumables 19 Lacrimal Punctum plugs (0.5mm), Medium Term, Dissolvable # Absorbable Punctum Plugs provide occlusion therapy of the lacrimal drainage system lasting approximately 180 days. Lacrisolve 180 is intended to temporarily treat the symptoms of dry eye disease, contact lens intolerance secondary to dry eye, and to increase efficacy of ocular medications and lubricants Nappi code: Surgical Skin Marker # Sterile, single use, Scrub resistant Gention Violet Ink. Packaged with 15cm ruler. Nappi code: Scleral Marker (3.5/4.0mm) # cm long and designed to be used as part of the intravitreal injection procedure for treatment of AMD. Two calibrated markers (3.5/4mm) to mark the injection point Nappi code: Cautery High Temp # High temperature cauteries are popular for many types of procedures including pinpoint hemostasis, evacuation of a subungual hematoma, controlling diffuse bleeders, vasectomies, and sculpting woven grafts Nappi code: Cautery Low Temp # Low temperature cauteries are popular for many types of procedures including pinpoint hemostasis. Nappi code: TBA.

20 Ophthalmic Drapes 20 Ophthalmic drapes custommanufactured for Iso Clear and its clients. Ophthalmic Drape with no aperture For cataract surgery # MS cm (L) x38cm (W) Adhesive size: 14cm x 18cm Nappi code: Ophthalmic Drape with Aperture For cataract surgery # MS cm (L) x38cm (W) Adhesive size: 14cm x 18cm Nappi code: Ophthalmic Drape For Posterior Surgery (Ex. PPV; Retinal) Double Pouch, No aperture Adhesive: 14cm x 18cm # MS1007 Nappi code: Lasik Drape # MS 6007 Mainly Lasik procedures in Theatre Incise Size: 15cm (L) x 10 cm (W) Nappi code: Shape/colour legend:

21 Latex Surgical Gloves (powder free) 21 Adopted by ophthalmic surgeons across the UK. Now available in South Africa. Founded in 2013 by the former leadership team of the world s most favoured brand of surgical gloves for the past 40 years, Leanvation have made a huge impact already in the United Kingdom. Leanvation Eco glove Sterile, powder-free latex surgical glove suited to a broad range of surgical specialties. Thickness: Finger 0.20mm Palm 0.18mm Cuff 0.14mm Leanvation Sensitive glove Sterile, powder-free latex surgical glove suited to surgical procedures demanding extreme levels of grip and heightened resistance to puncture. Thickness: Finger 0.24mm Palm 0.22mm Cuff 0.21mm Leanvation Senstex Sterile, powder-free latex surgical glove suited to surgical procedures demanding heightened levels of tactile sensitivity and comfort. Thickness: FInger 0.20mm Palm 0.18mm Cuff 0.16mm

22 Latex Surgical Gloves (powder free) 22 Leanvation Eco Innovation that delivers paradigm change in pricing and quality. The outcome of a quest to deliver maximum performance at minimum cost. Incremental changes, ranging from the use of generic chemical components, single colour & more compact packaging, and design changes that include a reduced length cuff, add up to deliver a huge cost saving. Suited to all surgical procedures, Leanvation Eco offers the potential for huge rationalisation, glove standardisation and reduced costs, while delivering improvements in clinical standards. Leanvation Senstex The ultimate in tactile sensitivity and comfort. Made from Leanvation s softest polymer formulation, Leanvation Senstex can be worn much closer to the skin than comparative gloves, affording wearers unparalleled levels of tactile sensitivity and control. 100% inspection, means every single pair of Leanvation Senstex is electronically inspected for freedom from holes and defects. Leanvation Sensitive Exceptional grip when you need it. A slightly thicker variant of the Leanvation Senstex, modified to offer extreme levels of grip. Wearers accustomed to extremely high grip variants of competitor products will experience even greater levels of control, yet will also be afforded a significant upgrade in comfort and tactile sensitivity owing to the same polymer formulation as Leanvation Senstex.

23 Appendix A Summarised Listing of Iso Clear Products 23

24 . Iso Clear (Pty) Ltd. BioPark Mark Shuttleworth Street The Innovation Hub Tshwane, South Africa Tel: Ursula: Tel: Craig: Web: Our goal is to deliver on our philosophy of: Quality, Innovation and Superior Customer Service

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