Contraceptives: Technologies and Global Markets

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1 A BCC Research Healthcare Report HLC085A Use this report to: Learn how shifting demographic and sociological factors such as population growth, proportion of young population, and perceptions about family planning and contraceptives are influencing the contraceptives market Identify the strengths and weaknesses of each type of contraceptive product, including novel formulations with low side effect profiles and new methods of administration Formulate business and marketing strategies to promote and differentiate products based on this detailed analysis of new technologies, growing competition, and changing consumer needs Understand the key issues driving competition in this field, such as increasing incidence of STDs/ STIs, patent expirations, safety issues, and a declining female population in prime childbearing years. T: , F: sales@bccresearch.com

2 Global sales of contraceptives in 2008 were $9.9 billion and, with 2% growth, sales reached $10.1 billion in This market is expected to rise at a CAGR of 4.8% and reach $13.5 billion by Introduction Contraception is a term used for the prevention of pregnancy, and it is often referred to as birth control. It is done through the use of hormones, devices or surgery to prevent a woman from becoming pregnant. While birth control choices are highly individual, all methods of birth control have the same goal to prevent pregnancy. Birth control methods range from mechanical methods that prevent sperm from entering the uterus, hormonal methods that prevent ovulation so that there is no egg to fertilize, or natural methods that require some human skill to perfect. The contraceptive market is a mature market. its practice is as old as human existence.ortho EVRA by Johnson & Johnson in 2002 was the first weekly contraceptive patch, providing women with a more convenient contraceptive option. The global barrier contraceptive market is primarily led by condoms occupying about 90% share. There are several methods of contraception, some of which are created for women and others for men. The economic downturn boosted the market, with people using more contraception methods to avoid births. This market is also being influenced by more awareness of sexually transmitted diseases. The BCC report -HLC085A provides an update of new developments in the market of contraception technology and also detailed market analysis of contraceptive products along with the factors affecting this market. This report also covers the acquisition strategies and collaborations by companies as well as the strength and weaknesses of each type of contraception method in light of new technologies, growing competition, and changing customer needs. The report is useful to the Analytical companies, physicians, the pharmaceutical and biopharmaceutical industries, hospitals and research institutes. The information for the report has been collected from both primary as well as the secondary sources. Data was collected through online research and correspondence with various analytical/ chemical/pharmaceutical/biotechnical experts.

3 Scope of Study The contraceptive market is led by hormonal contraceptives with more tha n a 78% share. This segment was worth $7.9 billion in 2009 and is expected to increase to $8.2 billion in 2010 and $9.4 billion by 2015, a compound annual growth rate of (CAGR) of 2.8%. The scope of the report is broad and includes: Breakdown of the global market by type, specifically barrier methods, such as condoms, spermicides, diaphragms, cervical caps, and contraceptive sponges; and hormonal methods, such as birth-control pills and patches, Depo-Provera, vaginal rings, and intrauterine devices (IUDs) Analysis of market trends, with data for 2008 and 2009, estimates for 2010, and projections of compound annual growth rates (CAGRs) through 2015 Overview of the efficacy for each birth-control measure and the risks involved Geographic breakdown of demand and production, economic trends, and social influences Comprehensive company profiles and patent analyses. Table of Contents Chapter One: Introduction Study Objectives Reasons for Doing This Study Intended Audience Scope of Report Methodology Information Sources About The Author Related BCC Research Reports BCC Online Services Disclaimer Chapter Two: Executive Summary Executive Summary Summary Table Worldwide Revenue of Contraceptive Market, Through 2015 Summary Figure Worldwide Revenue of Contraceptive Market, Chapter Three: Overview Definition Historical Perspective Table 1 Milestones in The Development of Contraceptives, 3,000 B.C Types of Contraception Figure 1 Types Of Contraception Mechanical Barriers Male Condom Table 2 Efficacy, Advantages, Disadvantages of Male Condom Female Condom Table 3 Efficacy, Advantages, Disadvantages of Female Condom Diaphragm Table 4 Efficacy, Advantages, Disadvantages of Diaphragm Cervical Cap Table 5 Efficacy, Advantages, Disadvantages of Diaphragm Table 6 Efficacy, Advantages, Disadvantages of Implants Table 7 Efficacy, Advantages, Disadvantages of Implants Injectable Depomedroxyprogesterone Acetate (DMPA) Table 8 Efficacy, Advantages, Disadvantages of DMPA Oral Contraceptives Progestin only Oral Contraceptives Table 9 Efficacy, Advantages, Disadvantages of Progestin Only Oral Contraceptives Combination Oral Contraceptives Table 10 Efficacy, Advantages, Disadvantages of Combination Oral Contraceptives Ninety One Day Combination Oral Contraceptives Combination Patch Contraceptive Table 11 Efficacy, Advantages, Disadvantages of Combination Oral Contraceptives Contraceptive Vaginal Ring Table 12 Efficacy, Advantages, Disadvantages of Contraceptive Vaginal Ring Intrauterine Devices (IUDs) Table 13 Efficacy, Advantages, Disadvantages of Intrauterine Devices Emergency Postcoital Contraception Table 14 Efficacy, Advantages, Disadvantages of Emergency Contraception Other Methods Periodic Abstinence Table 15 Efficacy, Advantages, Disadvantages of Periodic Abstinence Lactational Amenorrhea Table 16 Efficacy, Advantages, Disadvantages of Lactational Amenorrhea Natural Family Planning Table 17 Efficacy, Advantages, Disadvantages of Family Planning Method Sterilization Female Sterilization Table 18 Efficacy, Advantages, Disadvantages of Female Sterilization Male Sterilization Vasectomy Table 19 Efficacy, Advantages, Disadvantages of Female Sterilization Chapter Four: Regulatory Aspects Updates From The FDA Labeling for Ortho Evra Contraceptive Patch FDA Warnings for Nonoxynol 9 OTC Contraceptive Products New Drug Application Approvals of Contraceptive Products Table 20 New Device Approvals in Contraception, Table 21 Regulatory Chnages and Approvals in Contraception, Other Approvals The FDA Approval of Adiana Permanent Contraception

4 Table of Contents, continued Barrier contraceptives have a smaller market share than hormonal contraceptives but are expected to grow at a higher rate. This segment was worth $2 billion in 2009 and is expected to be valued at $2.3 billion in 2010 and $3.5 billion in 2015, an 8.5% compound annual growth rate (CAGR). The European Medicines Agency Marketing Approval for Ellaone Family Health International Seeks Approval of Chinese Contraceptive in Africa Table 22 Safety Alerts, Chapter Five: Prevalance of Contraceptives Contraceptive Prevalence Rate Table 23 Worldwide Prevalence of Contraceptives (%) Influences Behind A Slackened Pace Limited Method Mix Sheer Growth in Numbers Changing Demographic Profile within The Reproductive Years Proximate Determinants Chapter Six: Industry Structure Market Leaders in The Contraceptive Industry Hormonal Oral Contraceptives Table 24 Leading Manufacturers/Suppliers of Hormonal Oral Contraceptives Hormonal Contraceptive Devices Table 25 Leading Manufacturers/Suppliers of Hormonal Contraceptive Devices (Implants, Patches, Vaginal Rings, Iuds) Hormonal Injectable Contraceptives Table 26 Leading Manufacturers/Suppliers of Hormonal Injectable Contraceptive Devices Condoms Table 27 Leading Manufacturers/Suppliers of Condoms Cervical Caps/ Diaphragms and IUDs (Non Hormonal Devices) Table 28 Leading Manufacturers/Suppliers of Cervical Caps/ Diaphragms and IUDs Table 29 Leading Manufacturers/Suppliers of Others (Transcervical Sterilization) Table 30 Leading Manufacturers of Transcervical Sterilization Systems Market Shares of Industry Leaders Hormonal Oral Contraceptives Table 31 Worldwide Market Shares of Manufacturers/ Suppliers of Hormonal Oral Contraceptives, Figure 2 Worldwide Market Shares of Manufacturers/ Suppliers of Hormonal Oral Contraceptives, Hormonal Contraceptive Devices Table 32 Worldwide Market Shares of Manufacturers/ Suppliers of Hormonal Contraceptive Devices, Figure 3 Worldwide Market Shares of Manufacturers/ Suppliers of Hormonal Contraceptive Devices, Hormonal Injectable Contraceptives Table 33 Worldwide Market Shares of Manufacturers/ Suppliers of Hormonal Injectable Contraceptives, Figure 4 Worldwide Market Shares of Manufacturers/ Suppliers of Hormonal Injectable Contraceptives, Condoms Table 34 Worldwide Market Shares of Manufacturers/ suppliers of Condoms, Figure 5 Worldwide Market Shares of Manufacturers/ Suppliers of Condoms, Cervical Caps/ Diaphragms and IUDs (Non Hormonal Devices) Table 35 Worldwide Market Shares of Manufacturers/ Suppliers of Cervical Caps/ Diaphragms and IUDs, Figure 6 Worldwide Market Shares of Manufacturers/ Suppliers of Cervical Caps/ Diaphragms and IUDs, Table 36 Worldwide Market Shares of Manufacturers/ Suppliers of, Figure 7 Worldwide Market Shares of Manufacturers/ Suppliers of, Others (Transcervical Sterilization) Table 37 Worldwide Market Shares of Manufacturers of Transcervical Sterilization, Figure 8 Worldwide Market Shares of Manufacturers Transcervical Sterilization, Chapter Seven: New Developments New Contraceptive Choices Key Developments Table 38 Key Developments Available Or Soon To Be Available in Various Countries Recent Advances in Oral and Transdermal Contraception Table 39 Recent Advances in Oral and Transdermal Contraception Recent Advances in Male Contraception Table 40 Recent Advances in Male Contraception New Entities in Contraception Oral Contraceptives Table 41 New Developments In Hormonal Contraceptives Oral Contraceptives Contraceptive Devices Table 42 New Developments In Hormonal Contraceptive Devices Implants, Patch, Vaginal Ring, Intra Uterine Device (Iud) Recent Updates/ New Developments in The Contraceptive World Watson Pharmaceuticals, Inc. Bayer Schering Pharma Hra Pharma Schering Plough Chapter Eight: Market Analysis Table 43 Global Market for Through 2015 Figure 9 Worldwide Market for Hormonal Contraceptives Oral Contraceptives Table 44 Worldwide Market for Oral Contraceptives By Region Through 2015 Figure 10 Worldwide Market for Oral Contraceptives By Region Hormonal Devices Table 45 Worldwide Market for Hormonal Devices Used As Contraceptives By Region, Through 2015 Figure 11 Worldwide Market for Hormonal Devices Used As Contraceptives By Region, Injectable Contraceptives Table 46 Worldwide Market for Hormonal Injectable Contraceptives By Region, Through 2015 Figure 12 Worldwide Market for Hormonal Injectable Contraceptives By Region, Market Shares of Hormonal Contraceptive Market, By Region Table 47 Worldwide Market Figure 13 Worldwide Hormonal Contraceptive Market

5 Table of Contents, continued Table 48 Worldwide Market for, Through 2015 Figure 14 Worldwide Market for Table 49 Worldwide Market for Condoms By Region Through 2015 Figure 15 Worldwide Market for Condoms By Region Cervical Cap/ Diaphragm and IUD (Non Hormonal Devices) Table 50 Worldwide Market for Cervical Caps/ Diaphragms and IUDs By Region, Through 2015 Figure 16 Worldwide Market For Cervical Caps/ Diaphragms and IUDs By Region, Table 51 Worldwide Market for By Region, Through 2015 Figure 17 Worldwide Market for By Region Market Shares of Barrier Contraceptive Market, By Region Table 52 Worldwide Market Figure 18 Worldwide Barrier Contraceptive Market Other Contraceptives and Techniques Table 53 Worldwide Market for Transcervical Sterilization By Region, Through 2015 Figure 19 Worldwide Market For Transcervical Sterilization By Region, Market Shares of Contraceptive Market Table 54 Contraceptives Market Shares, Figure 20 Contraceptives Market Shares, Market Shares of Contraceptive Market, By Region Table 55 Worldwide Contraceptives Market Shares By Region, Figure 21 Worldwide Contraceptives Market Shares By Region, Chapter Nine: Patent Analysis Patents By Year Table 56 Number of Significant Patents By Year, 2006 Through 2010* Figure 22 Number of Patents By Year, Figure 23 Percentage of Patents By Year, Patents By Technology Table 57 Number of Patents By Technology, * Figure 24 Number Of Patents By Technology, * Patents By Type Table 58 Patents for Hormonal Contraceptive Types, Figure 25 Patents for Hormonal Contraceptive Types, Table 59 Patents for Barrier Contraceptive Types, Figure 26 Patents for Barrier Contraceptive Types, Others Table 60 Patents for Others Category, 2006 Through 2010* Figure 27 Patents for Others Category, Patents By Company Table 61 Number of U.S. Patents By Company for, Figure 28 Number of U.S. Patents By Company for, Table 62 Number of U.S. Patents By Company for, Figure 29 Number of U.S. Patents By Company for, Other Contraceptives Table 63 Number of U.S. Patents By Company for Other Contraceptives, Figure 30 Number of U.S. Patents By Company for Other Contraceptives, Patents By Country Table 64 Number of U.S. Patents By Country for, Figure 31 Number of U.S. Patents By Country for, Table 65 Patent Shares By Country for Hormonal Contraceptives, (%) Figure 32 Patent Shares By Country for Hormonal Contraceptives, (%) Table 66 Number of U.S. Patents By Country for, Figure 33 Number of U.S. Patents By Country for, Table 67 Patent Shares By Country for Barrier Contraceptives (%) Figure 34 Patent Shares By Country for Barrier Contraceptives (%) Other Contraceptives Table 68 Number of U.S. Patents By Country for Other Contraceptives, Figure 35 Number of U.S. Patents By Country for Other Contraceptives, Table 69 Patent Shares By Country for Other Contraceptives (%) Figure 36 Patent Shares By Country for Other Contraceptives (%) Patents By Assignee Table 70 Patents By Assignee for Hormonal Contraceptives Figure 37 Patents By Assginee for Hormonal Contraceptives Table 71 Patents By Assignee for Figure 38 Patents By Assginee for Other Contraceptives Table 72 Patents By Assignee for Other Contraceptives Figure 39 Patents By Assginee for Other Contraceptives Chapter Ten: Market Trends Summary of Demand and Production of Contraceptives Social Influences on Contraception Market Economic Trend s Influence on Contraception Factors Affecting The Sales of Contraceptives Increasing Awareness Competition

6 Table of Contents, continued Cost of The Drugs Patents Expirations Innovation Direct To Consumer Advertising Women at Risk Prevention of Teenage Preganancy and Stis Use of Condoms Use of Emergency Contraceptive Pills Barriers in ECP Access Role of The Healthcare Provider in Enhancing Adolescents Awareness and Use of ECPs Public Health Campaigns Chapter Eleven: Company Profiles Agile Therapeutics Ansell Healthcare, Inc. Ansell Limited Apothecus Pharmaceuticals Corporation Bayer Health Care/Bayer Schering Pharma Ag, Germany Bravo Condoms Caution Wear Corp. Church & Dwight Co., Inc. Conceptus, Inc. Condax Medical Products, Llc DKT International Durbin Plc Femcap, Inc. Global Protection Corp. Hologic Inc. Hra Pharma Janssen Cilag Pharma (A Johnson & Johnson Company) Marlborough Pharmaceuticals Ltd. Mayer Laboratories, Inc. Medtech Products Limited Merck & Co., Inc. Okamoto U.s.a., Inc Ortho Mcneil Janssen Pharmaceuticals, Inc. (A Johnson & Johnson Company) Pfizer Inc. Revive Personal Products Co. Ssl International, Plc Stragen Pharma Teva Pharmaceutical Industries Ltd. The Female Health Company (Fch) Veos, Plc Warner Chilcott Watson Pharmaceuticals, Inc. Williams Medical Supplies (Wms) Yama,inc. Appendix I abbreviations Abbreviations 146 pages 72 tables

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