Gynecologic Oncology

Transcription

1 Gynecologic Oncology

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3 Ramez N. Eskander Robert E. Bristow Editors Gynecologic Oncology A Pocketbook

4 Editors Ramez N. Eskander, M.D. Assistant Professor Division of Gynecologic Oncology Department of Obstetrics and Gynecology University of California, Irvine Medical Center Orange, CA, USA Robert E. Bristow, M.D., M.B.A. The Philip J. DiSaia Prestigious Chair in Gynecologic Oncology Professor and Director Division of Gynecologic Oncology Department of Obstetrics and Gynecology University of California, Irvine Medical Center Orange, CA, USA ISBN ISBN (ebook) DOI / Springer New York Heidelberg Dordrecht London Library of Congress Control Number: Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (

5 Preface It is with much enthusiasm that we introduce the first edition of Gynecologic Oncology: A Pocketbook. Medical students, house staff, fellows, and junior faculty are required to adapt to growing responsibilities, while simultaneously expanding their knowledge base and clinical acumen. In an era of online medicine, health care providers are faced with a growing obligation to rapidly and effectively access, understand, and share information relating to treatment planning and patient care. This task is difficult to accomplish using traditional textbooks, and requires a user-friendly print/electronic handbook that distills complex evaluation and management algorithms into easily accessible and understandable chapters. As an obstetrics and gynecology resident and gynecologic oncology fellow, such a source was lacking. This is what ultimately motivated the creation of this handbook. Divided into nine chapters focusing on disease site, radiation therapy, chemotherapy, critical care, palliative care, and end-of-life care, this handbook is efficiently structured to provide a mobile source of reliable information in bullet point and table format. Each disease section details epidemiology, genetics, staging, and surgical management with a comprehensive review of key clinical trials that inform current treatment. Additionally, the radiation, chemotherapy, critical v

6 vi Preface care, and palliative care chapters are analogously structured to provide essential information in a high-yield format unlike any companion handbook previously published. Ultimately, it is our hope that this handbook will emerge as a reliable reference and educational guide, complimenting the substantial information contained in the critical textbooks that serve as the pillars of gynecologic oncology education and training. We look forward to hearing from you, as we work to improve and build upon this first edition. Orange, CA, USA Ramez N. Eskander Robert E. Bristow

7 Acknowledgements This handbook is dedicated to our wives Michelle and Rachel, and our amazing children, Jackson, Chloe, Haley, Chloe, and Abigail, whose relentless support and encouragement have catalyzed our success. In addition, we would like to thank our colleagues and mentors for their guidance as well as our patients, whose courage and determination in the face of cancer are an inspirational and motivational force. vii

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9 Contents Section 1 Disease Sites 1 Epithelial Ovarian Cancer, Low Malignant Potential, and Sex Cord Stromal Tumors of the Ovary... 3 Ramez N. Eskander and Robert E. Bristow 2 Cervical Cancer Sara M. Jordan and Krishnansu S. Tewari 3 Cancer of the Vulva and Vagina Lauren Krill and Leslie M. Randall 4 Uterine Corpus Cancers Kristy K. Ward and Michael T. McHale 5 Gestational Trophoblastic Disease Elizabeth L. Dickson and Sally A. Mullany Section 2 Chemotherapy 6 Chemotherapy for Gynecologic Cancer Quan Li and Jack L. Watkins Section 3 Radiation Therapy 7 Radiation Therapy in Gynecologic Cancer Susan G.R. McDuff and Catheryn M. Yashar ix

10 x Contents Section 4 Critical Care 8 Critical Care Alexandre Buckley and Ana I. Tergas Section 5 Palliative Care 9 Palliative Care Solomon Liao, Rosene D. Pirrello, Rebecca Liddicoat Yamarik, and Jamie Capasso Index

11 Contributors Robert E. Bristow, M.D., M.B.A. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Irvine Medical Center, University of California, Orange, CA, USA Alexandre Buckley, M.D. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY, USA Columbia University Medical Center, New York, NY, USA Jamie Capasso, D.O. Department of Internal Medicine, Irvine Medical Center, University of California, Orange, CA, USA Elizabeth L. Dickson, M.D. Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women s Health, University of Minnesota Medical Center, Fairview, Minneapolis, MN, USA Ramez N. Eskander, M.D. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Irvine Medical Center, University of California, Orange, CA, USA Sara M. Jordan, M.D. Gynecologic Oncologist, Southwest Gynecologic Oncology Associates, Inc., Albuquerque, NM, USA Lauren Krill, M.D., M.S. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Irvine Medical Center, University of California, Orange, CA, USA xi

12 xii Contributors Quan Li, Pharm.D. Department of Pharmacy, The James Cancer Hospital, The Ohio State University, Columbus, OH, USA Solomon Liao, M.D., A.A.H.P.M. Department of Internal Medicine, Irvine Medical Center, University of California, Orange, CA, USA Susan G.R. McDuff, M.D., Ph.D. Department of Radiation Medicine and Applied Sciences, University of California San Diego Health System, La Jolla, CA, USA Michael T. McHale, M.D. Department of Reproductive Medicine, UC San Diego Moores Cancer Center, La Jolla, CA, USA Sally A. Mullany, M.D. Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women s Health, University of Minnesota Medical Center, Fairview, Minneapolis, MN, USA Rosene D. Pirrello, B.Pharm., R.Ph. Department of Pharmacy Services, UC Irvine Health Department of Pharmacy Services, Irvine Medical Center, University of California, Orange, CA, USA Leslie M. Randall, M.D. Department of Gynecologic Oncology, Irvine Medical Center, University of California, Orange, CA, USA Ana I. Tergas, M.D., M.P.H. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY, USA Krishnansu S. Tewari, M.D., F.A.C.O.G., F.A.C.S. The Division of Gynecologic Oncology, The Gynecologic Oncology Group at UC Irvine, Irvine Medical Center, University of California, Orange, CA, USA Kristy K. Ward, M.D., M.A.S. Department of Reproductive Medicine, UC San Diego Moores Cancer Center, La Jolla, CA, USA

13 Contributors xiii Jack L. Watkins, Pharm.D., B.C.O.P. Department of Clinical Effectiveness, University of Texas MD Anderson Cancer Center, Houston, TX, USA Rebecca Liddicoat Yamarik, M.D., M.P.H. Providence Trinity Care Hospice, Torrance, CA, USA Catheryn M. Yashar, M.D. Department of Radiation Medicine and Applied Sciences, University of California San Diego Health System, La Jolla, CA, USA