The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
|
|
- Noel Fleming
- 5 years ago
- Views:
Transcription
1 The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing. (AUSTRALIAN ADNI) July 2013 UPDATE Imaging Christopher Rowe MD Neuroimaging stream leader
2 June 2013 The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing. October 2006 Replacement MCI and smc Women s Healthy Aging Program 58 new participants AV-45 Funded anon 102 new participants Flutemetamol Funded by GE 105 new participants Florbetaben Funded by Bayer/Piramal 823 not imaged 738 not imaged Original Cohort 632 not imaged 83 participants Flutemetamol Funded by GE 92 participants AV-45 Funded anon 390 not imaged 288 imaged MRI + 11C-PiB Funded by CSIRO 230 imaged MRI + 11C-PiB Funded by CSIRO 172 imaged MRI and 11C-PiB Funded by SIEF 141 participants MRI and 11C-PiB Funded by SIEF 0 yrs 1.5 yrs 3 yrs 1112 recruited 968 remain 824 remain 4.5 yrs 718 remain plus 268 new
3 The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing. 3 year Data Release 221 subjects (, MCI, AD) with baseline PiB PET and MRI now with 3 year clinical data and 3 year PiB PET in 173 with MRI in Data and Samples - Access Data
4 Canada USA Colombia Mexico Cuba Argentina 540 research groups granted access to through ADNI website Denmark UK Ireland Germany France Spain Italy Belgium Netherlands Switzerland Poland Algeria Egypt Bulgaria Israel Turkey Finland Sweden India Pakistan Saudi Arabia Iran China Taiwan Japan Hong Kong Korea Australia New Zealand Includes access granted to the following companies: Abbott Labs, Abiant, ADM diagnostics, Astra Zeneca, Avid, BioClinica, Biogen Idec, Bristol-Myers Squibb, Cogstate Cytokinetics, Eisai, Elan, Eli Lilly, GE Health Care, General Resonance, Genetech, Imorphics, Iris Biotechnologies, Janssen, Johnson Johnson, M and M Scientific, Merck & Co, Mimvista, Pentara Corp, Pfizer, Philips, Predixion software, Rancho Biosciences, Servier, Siemens, Soft team solutions, UCB, United Biosource Corp.
5 Neocortical SUVR PiB neocortical SUVR % 99% % (n = 366) 1.40±0.4 (n = 195) MCI 1.91±0.6 (n = 92) AD 2.30±0.4 (n = 79)
6 Neocortical SUVR Longitudinal PiB PET 6-year follow-up yo male (e3/e3) 74 yo female (e3/e3) MMSE 29 MMSE 29 MMSE 29 MMSE 29 MMSE 28 MMSE 29 MCI MMSE 25 MCI MMSE 30 MMSE 26 MCI MMSE yo female (e3/e3) MMSE 29 MMSE 30 MMSE 29 MMSE 30 MMSE Time (months)
7
8 Rate of Ab deposition Relation between baseline Ab burden and rates of Ab deposition 3-5 year follow-up R 2 = 0.23 (p<0.0001) Baseline Ab burden
9 Rate of Ab deposition Rate of Ab deposition vs MMSE 3-5 year follow-up 0.10 MCI AD R 2 = 0.08 (p=0.0006) Baseline MMSE
10 MCI + AD The natural history of Ab deposition in sporadic AD 3.0 Neocortical SUVR cb + * SUVR/yr (95%CI SUVR/yr) 12.0 yr 19.2 yr (95%CI yrs) Mean SUVR AD+ (2.33) Mean SUVR - (1.17) - MCI- 1.0 (95%CI yrs) Time (years)
11 Biomarker magnitude Relationship between abnormality and CDR of 1.0 abnormal CDR 1.0 Ab deposition Hippocampal volume Episodic memory Grey matter volume Non-memory cut-off normal Time (years) non-demented demented
12 Risk of decline over 3 years: Positive vs negative amyloid scan (n=183) MCI (n=87) NEGATIVE (n=130) 25% to MCI/AD POSITIVE (n=53) 29% (8/27) to dementia NEGATIVE (n=27) 77% (46/60) to AD POSITIVE (n=60) Odds Ratio 4.8 (p = 0.001) Odds Ratio 7 ( p< 0.001) (OR increases to 14 if non-ad dementia removed)
13 MCI to AD over 3 years (n=87; 59% progressed) MCI positive for marker Odds Ratio PPV NPV HV ApoE-e CVLT< PiB PiB+e PiB+HV PiB+CVLT 43 na
14 Neocortical SUVR Predictive value of low (<1.4) vs intermediate vs high (>1.9) PiB binding PPV 82% 2.00 PPV 35% 1.50 PPV 17% PPV 44% 1.00 (n = 183) RASAD March 2012 MCI (n = 87) AD (n = 79)
15 CVLT-II Delayed Recall CVLT-II Delayed Recall over 36 mths PiB -ve n =122, SUVR = Mild Cognitive Impairment 8 PiB +ve n = 55, SUVR = PiB -ve n = 16, SUVR = Healthy Older Persons PiB +ve n = 32, SUVR = Baseline 18 months 36 months 2 Baseline 18 months 36 months
16 Rates of Ab deposition Ab burden Initial Ab burden is a better predictor of progression from MCI to AD than the rate of Ab accumulation p = p < non-converters converters non-converters converters OR = 5.4 OR = 15
17 Biomarker magnitude 17-23yrs Preclinical Stage CDR 1 Abnormal yrs 5-8yrs 1-3yrs Cut-points 1-2yrs Ab Amyloid Neuronal Injury Cognitive Symptoms Normal Cognitively Normal MCI Dementia Clinical disease stage
18 to MCI or AD over 3 years (n=183; 13% progressed) positive for marker OR PPV NPV HV e EM< PiB PiB+e PiB+HV PiB+EM AIBL composite EM Z-score <-1 (n=49), OR 11, PPV 35%, NPV 96% without correction for age or education.
19 Future Directions for AIBL Imaging Further refine prognostic value and comparative effectiveness of imaging biomarkers Replace 11 C-PiB with 18 F-NAV4694 Add Tau imaging Create a new pool of amyloid scan positive and MCI for early intervention trials Use AIBL infrastructure to support the A4 and DIAN therapy trials
20 Tau, Aβ and glucose metabolism in Alzheimer's disease patient [ 18 F]THK [ 11 C] PiB [ 18 F]FDG SUVR SUVR SUVR
21 Acknowledgements and thanks AIBL is a large collaborative study and a complete list of contributors and the management committee can be found at This research is funded in part by the Science and Industry Endowment Fund. We thank all who took part in the study.
The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing. (AUSTRALIAN ADNI) July 2012 UPDATE Imaging Christopher Rowe MD Neuroimaging stream leader October 2011 The Australian Imaging Biomarkers
More informationThe Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing an example of Australian research on Alzheimer s disease
The Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing an example of Australian research on Alzheimer s disease AIBL: Two site collaborative study Study is conducted at two sites: Perth
More informationStephen Salloway, M.D., M.S. Disclosure of Interest
Challenges in the Early Diagnosis of Alzheimer s Disease Stephen Salloway, MD, MS Professor of Neurology and Psychiatry Alpert Medical School, Brown University 2 nd Annual Early Alzheimer s Educational
More informationADNI PET CORE. Vancouver BC April Susan Landau, Andy Horng, Suzanne Baker, Bob Koeppe, Eric Reiman, Kewei Chen, Chet Mathis, Julie Price
ADNI PET CORE Vancouver BC April 2016 Susan Landau, Andy Horng, Suzanne Baker, Bob Koeppe, Eric Reiman, Kewei Chen, Chet Mathis, Julie Price ADNI FDG scan counts Number of FDG scans N SMC EMCI LMCI AD
More informationCognitive Aging: Defining normal vs. disease?
Cognitive Aging: Defining normal vs. disease? Reisa Sperling, M.D. Harvard Aging Brain Study Center for Alzheimer Research and Treatment Brigham and Women s Hospital Massachusetts General Hospital Harvard
More informationGlobal EHS Resource Center
Global EHS Resource Center Understand environmental and workplace safety requirements that affect your global operations. 800.372.1033 bna.com/gelw Global EHS Resource Center This comprehensive research
More informationMild Cognitive Impairment Symposium January 19 and 20, 2013
Highlights of Biomarker and Clinical Outcomes in Recent AD Treatment Trials Stephen Salloway, MD, MS Professor of Neurology and Psychiatry Alpert Medical School, Brown University Mild Cognitive Impairment
More informationWorld Connections Committee (WCC) Report
World Connections Committee (WCC) Report 06 Co-Dependents Anonymous Service Conference Countries Where CoDA Exists This report reflects the World Connections Committee (WCC) support of the growth and development
More informationAll about interrai. Len Gray Coordinator, interrai Network of Excellence in Acute Care April
All about interrai Len Gray Coordinator, interrai Network of Excellence in Acute Care April 2014 The interrai research collaborative Australia Belgium Canada Chile China Czech Republic Denmark Estonia
More informationA Summary of Childhood Cancer Statistics in Australia,
What is the Australian Paediatric Cancer Registry (APCR)? The APCR is one of only a few national registries of childhood cancer in the world. It covers all Australian children aged 0-14 years old at diagnosis.
More informationImplementation of fully automated immunoassays for CSF Aβ 1-42, t-tau and p-tau 181 in the Alzheimer s Disease Neuroimaging Initiative
Implementation of fully automated immunoassays for CSF Aβ 1-42, t-tau and p-tau 181 in the Alzheimer s Disease Neuroimaging Initiative Leslie M Shaw Perelman School of Medicine, University of Pennsylvania
More informationAppendix F: Test-Curriculum Matching Analysis
Appendix F: Test-Curriculum Matching Analysis TIMSS went to great lengths to ensure that comparisons of student achievement across countries would be as fair and equitable as possible. The TIMSS 2015 Assessment
More informationADNI PET CORE. Boston April Bill Jagust, Suzanne Baker, Bob Koeppe, Eric Reiman, Kewei Chen, Chet Mathis, Julie Price
ADNI PET CORE Boston April 27 Bill Jagust, Suzanne Baker, Bob Koeppe, Eric Reiman, Kewei Chen, Chet Mathis, Julie Price ADNI Florbetapir scan counts Number of Florbetapir scans N SMC EMCI LMCI AD Total
More information- Network for Excellence in Health Innovation
Real-world evidence is evidence from any and all sources of data that may contribute to more effective health care, including health care best tailored to the needs of individual patients. - Network for
More informationETB Data. there was. compared
AETA 2009 Survey Report Introduction Included in this report are survey data collected from the member embryo transfer business ss (ETB s) of the American Embryo Transfer Association for 2009. This report
More informationCountry-wise and Item-wise Exports of Animal By Products Value Rs. Lakh Quantity in '000 Unit: Kgs Source: MoC Export Import Data Bank
Country-wise and Item-wise Exports of Animal By Products Value Rs. Lakh Quantity in '000 Unit: Kgs Source: MoC Export Import Data Bank Country CAPEXIL Description HS Code Value 2010-2011 Quantity 2010-2011
More informationInjection Techniques Questionnaire (ITQ) WorldWide Results Needle Gauge
Injection Techniques Questionnaire (ITQ) WorldWide Results 2014-2015 Needle Gauge BACKGROUND All needles are at least twice as long as the skin is thick More than twice as long 31G =.26mm Surface = 1
More informationSperm donation Oocyte donation. Hong Kong þ Guideline þ þ Hungary þ þ þ þ Israel þ þ þ þ Italy þ þ þ. Germany þ þ þ þ Greece þ þ þ þ
CHAPTER 8: Donation Although there has been a reduction in the use of donor sperm because of ICSI and the impact of the removal of anonymity in some countries (1), sperm donation is still used and has
More informationSaudi Arabia February Pr Michel KOMAJDA. Université Pierre et Marie Curie Hospital Pitié Salpétrière
Prevention of Cardiovascular events with Ivabradine: The SHIFT Study Saudi Arabia February 2011 Pr Michel KOMAJDA Université Pierre et Marie Curie Hospital Pitié Salpétrière Paris FRANCE Declaration Of
More informationFor personal use only
ASX Announcement Melbourne, 29 July 2011 CogState CogState (ASX:CGS) today provided further details of its financial results for the year ended 30 June 2011 along with an update in respect of progress
More informationFOURIER STUDY GREYLOCK PRESS: CTS PRODUCT SAMPLE - FOURIER YES. Did the study achieve its main objective?
FOURIER STUDY Did the study achieve its main objective? 2 15% 1 5% 9.8% YES FOURIER compared Repatha with placebo in patients who were taking a statin and had hardening or narrowing of the arteries and
More informationKenneth W. Mahaffey, MD and Keith AA Fox, MB ChB
Once-daily oral direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation Kenneth W. Mahaffey, MD and Keith AA Fox, MB ChB on behalf
More informationTerms and Conditions. VISA Global Customer Assistance Services
Terms and Conditions VISA Global Customer Assistance Services Visa Global Customer Assistance Services (VGCAS) 1 The Visa Global Customer Assistance Services are co-ordinated by the Global Assistance Centre
More informationEU Market Situation for Poultry. Committee for the Common Organisation of the Agricultural Markets 20 April 2017
EU Market Situation for Poultry Committee for the Common Organisation of the Agricultural Markets 2 April 217 -9.% -11.% -5.% -.1% -.7% -2.2% 3.% 1.7% 1.2%.8%.6%.%.%.% 7.9% 7.% 6.4% 6.2% 6.% 5.5% 5.3%
More informationBio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c. VARIANT II TURBO Link System. Fully-Automated HbA 1c Testing
Bio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c VARIANT II TURBO Link System Fully-Automated HbA 1c Testing Bio-Rad Laboratories HEMOGLOBIN Testing VARIANT II TURBO Link System Efficient streamlined
More informationMain developments in past 24 hours
ECDC DAILY UPDATE Pandemic (H1N1) 2009 Update 02 October 2009, 09:00 hours CEST Main developments in past 24 hours Weekly Influenza Surveillance Overview to be published today; Media highlights and Eurosurveillance
More informationBio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c. VARIANT II TURBO Link. Fully-Automated HbA 1c Testing
Bio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c VARIANT II TURBO Link Fully-Automated HbA 1c Testing Bio-Rad Laboratories HEMOGLOBIN Testing VARIANT II TURBO Link Efficient streamlined process Powerful
More informationModelling diabetes Professor Alastair Gray Health Economics Research Centre University of Oxford
Oxford Technology Showcase 2016 Big Healthcare Challenges in chronic disease Modelling diabetes Professor Alastair Gray Health Economics Research Centre University of Oxford Chronic diseases.. are long-term
More informationU.S. Army Medical Research and Materiel Command Fort Detrick, Maryland
AWARD NUMBER: W81XWH-14-1-0418 TITLE: Tau and Beta-Amyloid Deposition, Micro hemorrhage and Brain Function after Traumatic Brain Injury in War Veterans PRINCIPAL INVESTIGATOR: Christopher Rowe CONTRACTING
More informationJoint Programming in Neurodegenerative Disease Research (JPND)
Joint Programming in Neurodegenerative Disease Research (JPND) Building Alliances and Collaborations Prof. Philippe Amouyel, MD, PhD JPND Chair France Disclosure CEO of Fondation Plan Alzheimer Conference
More informationIl processo diagnostico dell Alzheimer dalla clinica al neuroimaging Giovanni B. Frisoni M.D.
Il processo diagnostico dell Alzheimer dalla clinica al neuroimaging Giovanni B. Frisoni M.D. Professor of Clinical Neurosciences, University of Geneva Médecin Responsable, Memory Clinic, Hôpitaux Universitaires
More informationEnriched RWE study in the Nordics a case study
Enriched RWE study in the Nordics a case study RWD conf. Helsinki, November 28, 2018 Susanne Kihlblom, MSc Pharm., Diplom.Clin.Trials Copyright 2017 IQVIA. All rights reserved. IQVIA 2017. All rights reserved.
More informationIOSH No Time to Lose campaign: working together to tackle asbestos-related cancer #NTTLasbestos. Jonathan Hughes IOSH Vice President
IOSH No Time to Lose campaign: working together to tackle asbestos-related cancer #NTTLasbestos Jonathan Hughes IOSH Vice President About the Institution of Occupational Safety and Health (IOSH) www.iosh.co.uk
More informationPharmaceutical, Medical and Health-related Government and Regulatory bodies around the world.
1 International International Conference on Harmonization (ICH) World Health Organization (WHO) 2 Argentina National Administration of Drugs, Food and medical Technology. Australia s Department of health
More informationBioArctic announces detailed results of the BAN2401 Phase 2b study in early Alzheimer s disease presented at AAIC 2018
Press release BioArctic announces detailed results of the BAN2401 Phase 2b study in early Alzheimer s disease presented at AAIC 2018 Stockholm, Sweden, July 25, 2018 BioArctic AB (publ) (Nasdaq Stockholm:
More information508 the number of suicide deaths in deaths per 100,000 people was the suicide rate in Suicide deaths in 2013 by gender
An overview of suicide statistics This document summarises information about suicide deaths in New Zealand covering up to 13. It does not attempt to explain causes of suicidal behaviour or causes of changes
More informationInjection Techniques Questionnaire (ITQ) WorldWide Results Insulin Usage
Injection Techniques Questionnaire (ITQ) WorldWide Results 2014-2015 Insulin Usage BACKGROUND Lipohypertrophy in Diabetes or How much does a lipo cost? Dr. Treichel, Magdeburg Studies * have shown that
More informationAnxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study
Edith Cowan University Research Online ECU Publications Post 2013 2014 Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study
More informationEarly Diagnosis of Alzheimer s Disease and MCI via Imaging and Pattern Analysis Methods. Christos Davatzikos, Ph.D.
Early Diagnosis of Alzheimer s Disease and MCI via Imaging and Pattern Analysis Methods Christos Davatzikos, Ph.D. Director, Section of Biomedical Image Analysis Professor of Radiology http://www.rad.upenn.edu/sbia
More informationSchedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK ISO/IEC 17021-1:2015 to provide quality management systems Davy Avenue Knowhill Milton Keynes MK5 8NL Contact: Dr Eugene Kotlirov Tel: +44
More informationUnderstanding Symptoms, Causes, and Risks for Alzheimer s Disease
Understanding Symptoms, Causes, and Risks for Alzheimer s Disease Gene E. Alexander, Ph.D., Professor of Psychology, Neuroscience, and Physiological Sciences; Director, Brain Imaging, Behavior & Aging
More informationLarge observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG-SAFE)
Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG-SAFE) John Laffey, Giacomo Bellani, Tai Pham, Eddy Fan, Antonio Pesenti on behalf of the LUNG SAFE Investigators
More informationBioPlex 2200 Infectious Disease Panels
BioPlex 2200 System BioPlex 2200 Infectious Disease Panels An Expanding Multiplexed Assay Menu Lyme HIV Ag-Ab MMV IgM Syphilis Total & RPR MMRV EBV HSV-1 & HSV-2 EBV IgM ToRC IgM ToRC Leading the way with
More informationDesign and Analysis of a Cancer Prevention Trial: Plans and Results. Matthew Somerville 09 November 2009
Design and Analysis of a Cancer Prevention Trial: Plans and Results Matthew Somerville 09 November 2009 Overview Objective: Review the planned analyses for a large prostate cancer prevention study and
More informationJapanese perspective on CSF diagnostics
Japanese perspective on CSF diagnostics March 28, 2012 RASAD Department of Neuropathology, Graduate School of Medicine University of Tokyo Principal Investigator of J-ADNI Takeshi Iwatsubo Brain Research
More informationAllied Health: Sustainable Integrated Health Care for all Australians
Allied Health: Sustainable Integrated Health Care for all Australians Catherine Turnbull Chief Allied and Scientific Health Advisor SA Health Presentation to Indigenous Allied Health Australia Conference,
More informationImmunohematology. IH-QC Modular System. Select. Combine. Control.
Immunohematology IH-QC Modular System Select. Combine. Control. IH-QC Modular System Select. Combine. Control. Transfusion guidelines recommend regular checking of test materials, test methods, local working
More informationCAMD Annual Regulatory Science Workshop CSF Biomarker Team Refocusing on Low Hanging Fruit
CAMD Annual Regulatory Science Workshop CSF Biomarker Team Refocusing on Low Hanging Fruit October 19, 2016 Mary Savage, Co-Chair (seeking additional co-chair) Director, Companion Diagnostics Merck & Co.,
More informationLouisville '19 Attachment #69
Telephone Meeting Approved and why I propose Using zoom to fulfill both Phone and Virtual video meeting Formats. The first established phone meeting Sanctioned by Gamblers Anonymous (listed on Trustee
More informationMen & Health Work. Difference can make a difference Steve Boorman & Ian Banks RSPH Academy 2013
Men & Health Promotion @ Work Difference can make a difference Steve Boorman & Ian Banks RSPH Academy 2013 Difference can make a Difference Mens health: State of mens health Use of services Role of the
More informationNobelProcera Implant Bar Overdenture EXPERIENCE THE NEW WORLD OF CAD/CAM DENTISTRY
NobelProcera Implant Bar Overdenture EXPERIENCE THE NEW WORLD OF CAD/CAM DENTISTRY 2 NobelProcera Implant Bar Overdenture NobelProcera Implant Bar Overdenture complete range of fixed and removable solutions.
More informationOutline. Facts and figures Action plans Early / correct diagnosis Conclusions
Outline Facts and figures Action plans Early / correct diagnosis Conclusions Dementia: the greatest chalenge. Time to act now Philip Scheltens Professor of Neurology VU University Medical Center Amsterdam
More informationESPEN Congress Geneva 2014 FOOD: THE FACTOR RESHAPING THE SIZE OF THE PLANET
ESPEN Congress Geneva 2014 FOOD: THE FACTOR RESHAPING THE SIZE OF THE PLANET Buy 2 and take 3: are we benefitting from cheaper food? P. Marques-Vidal (CH) Pedro Marques-Vidal Department of Internal Medicine
More informationUndetectable = Untransmittable. Mariah Wilberg Communications Specialist
Undetectable = Untransmittable Mariah Wilberg Communications Specialist Undetectable=Untransmittable PLWH who get and stay undetectable have effectively no risk of transmitting HIV to their sex partners
More informationAvailable Hepatitis Information: how can this be used to convince decision makers and potential funders
Available Hepatitis Information: how can this be used to convince decision makers and potential funders H. Razavi June 6, 2015 Viral Hepatitis Prevention Board Meeting, London, UK 56 June 2015 It s not
More informationUSE OF BIOMARKERS TO DISTINGUISH SUBTYPES OF DEMENTIA. SGEC Webinar Handouts 1/18/2013
Please visit our website for more information http://sgec.stanford.edu/ SGEC Webinar Handouts 1/18/2013 2013 WEBINAR SERIES STATE OF THE SCIENCE: DEMENTIA EVALUATION AND MANAGEMENT AMONG DIVERSE OLDER
More informationType 1 Diabetes Australian Research Impact Analysis
Type 1 Diabetes Australian Research Impact Analysis Executive Overview Summary Type 1 diabetes research in Australia Australia is making a significant contribution to the quantity and quality of the global
More informationMild Cognitive Impairment (MCI)
October 19, 2018 Mild Cognitive Impairment (MCI) Yonas E. Geda, MD, MSc Professor of Neurology and Psychiatry Consultant, Departments of Psychiatry & Psychology, and Neurology Mayo Clinic College of Medicine
More informationCardiac Assessment Controls
Bio-Rad Laboratories CARDIAC ASSESSMENT CONTROLS Cardiac Assessment Controls Value Assigned for Clinical Laboratory and Point of Care Test Systems Solving the Challenges of Troponin I Testing for the Central
More informationTammie Benzinger, MD, PhD
Tammie Benzinger, MD, PhD benzingert@wustl.edu Disclosure: Tammie L.S. Benzinger, M.D., Ph.D. Research Support / Grants: NIH/NIA 5P01AG026276, 1U01AG032438, AG003991-27, 1R01NS066905-01, 1P01NS059560-01A1,
More informationMRI Hippocampal Volume for Enrichment
MRI Hippocampal Volume for Enrichment Derek Hill 1,2 & Jerry Novak 3, Pat Cole 4, Diane Stephenson 5 1. IXICO plc 2. UCL, London, UK 3. Johnson and Johnson 4. Takeda 5. CAMD, Critical Path Institute 1
More informationThe Test-Curriculum Matching Analysis: Science
Appendix C The Test-Curriculum Matching Analysis: Science TIMSS went to great lengths to ensure that comparisons of student achievement across countries would be as fair and equitable as possible. The
More informationField of Post-M.D. Training
TABLE C-1 (GRADUATES OF CANADIAN MEDICAL SCHOOLS) RANK Family Medicine Emergency Medicine (CFPC) Care of the Elderly (CFPC) Enhanced Skills: Other Fam. Med. Training FAMILY MEDICINE SUBTOTAL Anesthesiology
More informationAlzheimer s Disease Update: From Treatment to Prevention
Alzheimer s Disease Update: From Treatment to Prevention Jeffrey M. Burns, MD Edward H. Hashinger Professor of Medicine Co-Director, KU Alzheimer s Disease Center Director, Clinical and Translational Science
More informationPopulation- based cancer survival estimates
Population- based cancer survival estimates Represent average prognosis of cancer in a specific population Socio-economic features Health care seeking behaviours Coverage and quality of health care services
More informationD7.1 Report summarising results of survey of EU countries to identify volumes and trends in relation to the import and export of stem cells
Disclaimer: The content of this Deliverable represents the views of the author only and is his/her sole responsibility; it cannot be considered to reflect the views of the European Commission and/or the
More informationD7.1 Report summarising results of survey of EU countries to identify volumes and trends in relation to the import and export of stem cells
Disclaimer: The content of this Deliverable represents the views of the author only and is his/her sole responsibility; it cannot be considered to reflect the views of the European Commission and/or the
More informationAppendix F. The Test-Curriculum Matching Analysis Science TIMSS 2011 INTERNATIONAL RESULTS IN SCIENCE APPENDIX F 479
Appendix F The Test-Curriculum Matching Analysis Science TIMSS 2011 INTERNATIONAL RESULTS IN SCIENCE APPENDIX F 479 TIMSS went to great lengths to ensure that comparisons of student achievement across
More informationFRAX Based Guidelines: Is a Universal Model Appropriate?
FRAX Based Guidelines: Is a Universal Model Appropriate? Marlene Chakhtoura, MD Research Fellow Calcium Metabolism & Osteoporosis Program WHO Collaborating Center for Metabolic Bone Disorders American
More informationInfectious Disease Testing. ULTRA Product Line. Safety is not a Matter of Chance
Infectious Disease Testing ULTRA Product Line Safety is not a Matter of Chance ULTRA Product Line The best answer for HBV, HCV and HIV screening: a global automated solution for safe results. Monolisa
More informationRecommended composition of influenza virus vaccines for use in the 2007 influenza season
Recommended composition of influenza virus vaccines for use in the 2007 influenza season September 2006 This recommendation relates to the composition of vaccines for the forthcoming winter in the southern
More informationCurrent State of Global HIV Care Continua. Reuben Granich 1, Somya Gupta 1, Irene Hall 2, John Aberle-Grasse 2, Shannon Hader 2, Jonathan Mermin 2
Current State of Global HIV Care Continua Reuben Granich 1, Somya Gupta 1, Irene Hall 2, John Aberle-Grasse 2, Shannon Hader 2, Jonathan Mermin 2 1) International Association of Providers of AIDS Care
More informationGLOBAL FMD SITUATION DURING 2001/2002
APPENDIX 2 GLOBAL FMD SITUATION DURING 2001/2002 Report of the FAO/OIE World Reference Laboratory for FMD, Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey GU24 ONF, United Kingdom Tables
More informationAT RISK, SCI, EMCI: THE ALPHABET SOUP OF PRECLINICAL AND PRODROMAL ALZHEIMER DISEASE
AT RISK, SCI, EMCI: THE ALPHABET SOUP OF PRECLINICAL AND PRODROMAL ALZHEIMER DISEASE Mary Ellen Quiceno, MD, FAAN Associate Professor of Neurology Mary Quiceno, MD discloses she has received honoraria
More informationA. Personal Statement
BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME: Norman L. Foster
More informationTGX and TGX Stain-Free FastCast Acrylamide Kits
Electrophoresis TGX and TGX Stain-Free FastCast Acrylamide Kits The newest frontier for handcast gels It s Time to Expect More from Handcast Gels! FastCast kits provide unparalleled convenience and performance.
More informationThe first and only fully-automated, multiplexed solution for Measles, Mumps, Rubella and Varicella-zoster virus antibody testing
Bio-Rad Laboratories BioPlex 2200 System BioPlex 2200 MMRV IgG Kit The first and only fully-automated, multiplexed solution for Measles, Mumps, Rubella and Varicella-zoster virus antibody testing Bio-Rad
More informationAccess to treatment and disease burden
Access to treatment and disease burden Robert Flisiak Department of Infectious Diseases and Hepatology Medical University in Białystok, Poland Moulin de Vernègues, 27-29 August 2015 Disclosures Advisor
More informationORBE Summary of Benefits
www.wellaway.com ORBE Summary of Benefits www.wellaway.com Summary of Benefits Annual Limit 5,000,000 Coinsurance ORBE 90 ORBE 100 WellAway s share of costs on a covered service Your share of costs on
More informationMENTAL HEALTH CARE. OECD HCQI Expert meeting 17 th of May, Rie Fujisawa
MENTAL HEALTH CARE OECD HCQI Expert meeting 17 th of May, 2013 Rie Fujisawa Mental health indicators Any hospital readmissions for patients with schizophrenia Same hospital readmissions for patients with
More informationThe worldwide overview: updated (2005-6) meta-analyses of hormonal treatment trials
The worldwide overview: updated (2005-6) meta-analyses of hormonal treatment trials Richard Gray, for the Early Breast Cancer Trialists Collaborative Group (EBCTCG) Main questions, 2005-6 1) 5 years of
More informationo Dental Implants Market By Material, Type, Structure Global Forecast To 2022 Report ID: MRDH Publishing Date: July, 2017
o Dental Implants Market By Material, Type, Structure Global Forecast To 2022 Report ID: MRDH-10401 Publishing Date: July, 2017 Sr. No. License Type Price 1 Single User License $4,175.00 2 Multiple User
More informationA New Genetic Test for Alzheimer s Disease and Dementia Risk with transformational potential
A New Genetic Test for Alzheimer s Disease and Dementia Risk with transformational potential A Polygenic Risk Score test for Alzheimer s Disease variatect TM and SNPfitR TM provide an accurate genetic
More informationWhat is the extent of gender bias in bioinformatics?
What is the extent of gender bias in bioinformatics? Keith R. Bradnam krbradnam@ucdavis.edu, @kbradnam Genome Center, University of California, Davis Introduction As a male bioinformatician, I was curious
More informationMolecular Diagnostics Market Share, Size, Analysis, Growth, Trends and Forecasts, 2016 to 2024 Hexa Research
Molecular Diagnostics Market Share, Size, Analysis, Growth, Trends and Forecasts, 2016 to 2024 Hexa Research " Projected to grow at a CAGR of almost 9% from 2016 to 2024, the molecular diagnostics market
More informationDementia, Cognitive Aging Services and Support
Dementia, Cognitive Aging Services and Support Ronald C. Petersen, Ph.D., M.D. Professor of Neurology Mayo Clinic College of Medicine Rochester, MN NASUAD Washington September 2, 2015 Disclosures Pfizer,
More informationHealth and the Domestic Environment. Accidents Mental health Respiratory health Cardiovascular health. Xcess winter mortality
Health and the Domestic Environment Accidents Mental health Respiratory health Cardiovascular health Xcess winter mortality Lung Health and the Domestic Environment Indoor environment health effects: Asthma
More informationChemical compatibility of the Pall QPoint TM Docking Station - Tap Assembly with common surface disinfectants
Technical Report.78a Chemical compatibility of the Pall QPoint TM - Tap Assembly with common surface disinfectants QPoint - More than Filtration .0 Background The Pall QPoint Tap Water Filter Assembly
More informationCountry Length Discount Travel Period Anguilla All 20% off 08/24/11 12/15/11 Antigua All 20% off 08/24/11 12/15/11 Argentina All 20% off 08/24/11
Country Length Discount Travel Period Anguilla All 20% off 08/24/11 12/15/11 Antigua All 20% off 08/24/11 12/15/11 Argentina All 20% off 08/24/11 12/15/11 Aruba All 20% off 08/24/11 12/15/11 Australia
More information3.1 PHASE 2 OF THE GLOBAL PROJECT
RESULTS CHAPTER 3 3.1 PHASE 2 OF THE GLOBAL PROJECT (1996 1999) This new report of the Global Project provides data on anti-tuberculosis drug resistance from 58 geographical settings. Of these, 28 provided
More informationNobelProcera Implant Bar Overdenture complete range of fixed and removable solutions.
NobelProcera Implant Bar Overdenture EXPERIENCE THE NEW WORLD OF CAD/CAM DENTISTRY 2 NobelProcera Implant Bar Overdenture NobelProcera Implant Bar Overdenture complete range of fixed and removable solutions.
More informationWELLNESS COACHING. Wellness & Personal Fitness Solution Providers
WELLNESS COACHING Wellness & Personal Fitness Solution Providers Introducing Ourselves... We are Personal Wellness Coaches 2 We help people look and feel better by: - Educating on proper nutrition (80%)
More informationSirtex Medical Limited (ASX:SRX)
Sirtex Medical Limited (ASX:SRX) Macquarie Australia Conference Mr Gilman Wong, CEO Dr David Cade, CMO Sydney, 8 th May 2014 SIR-Spheres is a registered trademark of Sirtex SIR-Spheres Pty Ltd 1 Understanding
More informationFRAX Based Lebanese Osteoporosis Guidelines Second Update for Lebanese Guidelines for Osteoporosis Assessment and Treatment
These guidelines are endorsed by the following Lebanese Scientific Societies and Associations: Lebanese Society of Endocrinology Diabetes and Lipids, Lebanese Society of Rheumatology, Lebanese Society
More informationEXPEDITION3: A Phase 3 Trial of Solanezumab in Mild Dementia due to Alzheimer s Disease
EXPEDITION3: A Phase 3 Trial of in Mild Dementia due to Alzheimer s Disease Lawrence S. Honig, MD, PhD On behalf of the EXPEDITION3 Study Team Disclosure Statement I will discuss investigational use only.
More informationNEWSLETTER AIBL STUDY
NEWSLETTER AIBL STUDY August 2016 THE FLOREY INSTITUTE OF NEUROSCIENCEAND MENTAL HEALTH EDITH COWAN UNIVERSITY AUSTIN HEALTH AIBL Study Update from Prof. David Ames The AIBL study is now in its tenth year
More informationImproving Food Process Control Using the
Improving Food Process Control Using the UPLC Amino Acid Analysis Solution Hillary B. Hewitson, Thomas E. Wheat, Diane M. Diehl INTRODUCTION Food products have different desirability and value based in
More informationSummary of Results for Laypersons
What was the Study Called? Summary of Results for Laypersons A Randomized, Double-blind, Parallel-group, Placebo- and Active-controlled, Multicenter Study to Evaluate the Efficacy, Safety and Tolerability
More informationThe Terry Fox Foundation International
The Terry Fox Foundation International Background Terry Fox was a Canadian athlete, humanitarian, and cancer research activist. After losing his leg to cancer at only 18 years of age, Terry set out to
More informationDirectory of Open Access Journals: A Scientrometric Study of Surgery Journals. Dr. Kotti Thavamani, Ph.D. Regional Medical Library
Special Issue on Bibliometric & Scientometric Studies Directory of Open Access Journals: A Scientrometric Study of Surgery Journals Dr. Kotti Thavamani, Ph.D. Regional Medical Library The Tamil Nadu Dr.
More information