Obesity and Breast Cancer in a Multiethnic Population. Gertraud Maskarinec, MD, PhD University of Hawaii Cancer Center, Honolulu, HI
|
|
- Sheila Morgan
- 5 years ago
- Views:
Transcription
1 Obesity and Breast Cancer in a Multiethnic Population Gertraud Maskarinec, MD, PhD University of Hawaii Cancer Center, Honolulu, HI
2 Background Breast cancer incidence remains lower in many Asian than Western countries Risk in Asian migrants to the United States has increased over several generations Excess body weight is a risk factor for postmenopausal breast cancer and predicts worse survival Persons of Asian ancestry appear to have a high risk to develop diabetes and other chronic diseases despite a relatively low body weight Question: Is the influence of adiposity on breast cancer risk and prognosis stronger in Asian/Asian American than in white women?
3 Outline Multiethnic Cohort Breast cancer incidence in Asians and Asian Americans Obesity rates in Asians and Asian Americans Obesity and breast cancer risk in Asians/Asian Americans BMI Weight gain Waist-hip ratio Breast cancer survival in Asians/Asian Americans Possible mechanisms Body fat distribution Adipokines Conclusions
4 Multiethnic Cohort Study Baseline , 26 page self-administered questionnaire Validated food frequency questionnaire Sent to residents of Hawaii and Los Angeles County Names were obtained through drivers license records, voter registration records, and Medicare files Limited to ages years Ethnic distribution of 215,251 participants Japanese American (26.4%) White (22.9%) Latino (22.0%) African American (16.3%) Native Hawaiian (6.5%) Other ancestry (5.8%) Short follow-up questionnaire after 5 years Biorepository collection in : N=67,594 (49.7% of eligible) Repeated FFQ after 10 years
5 MEC Questionnaire
6 Breast Cancer Incidence in Japanese Immigrants and Caucasians Kolonel et al. Japan Scientific Societies Press Incidence per 100, st Gen. 2nd Gen. Caucasian Japan Hawaii
7 Breast Cancer in Hawaii and Japan Japan Hawaii (Japanese) Hawaii (Caucasian)
8 Breast Cancer Risk - Multiethnic Cohort Pike et al. CEBP 2002 W AA NH JA L-US L-NUS Total All postmenopausal N 20,794 18,527 5,918 23,638 9,874 9,961 88,712 Cases ,757 RR IR* All women with natural menopause or bilateral oophorectomy N 14,079 9,527 3,636 16,576 5,930 5,616 55,364 Cases ,116 RR IR* *Adjusted to 1970 US Standard Population ages years
9
10
11 Overweight by Ethnicity in Hawaii Maskarinec et al. Breast Ca Res & Treat 2006 (%) 100 Native Hawaiian Caucasian Japanese H: 62% to 72%, p = Study Year
12 Obesity in the Multiethnic Cohort Kolonel et al. Am J Epidemiol Men Women Haw J-A Cauc A-A Latino
13 BMI by Ethnicity - Multiethnic Cohort White et al. Int J Cancer Age 21 Baseline 0 White African Am Nat Hawaiian Japanese Latina
14 Diabetes Risk by BMI - MEC Maskarinec et al. Diabetes 2009 Caucasian Native Hawaiian Japanese American Hazard ratio <
15 Type 2 Diabetes in East Asians: Similarities & Differences with Populations in Europe & US Annals of the New York Academy of Science 2013
16 Breast Cancer Risk by BMI at BL White et al. Int J Cancer Overweight Obese P for interaction = 0.03 * 1.6 * * * * * 1 White African Am Nat Hawaiian Japanese Latina *p>0.05
17 Breast Cancer by Weight Gain since 21 White et al. Int J Cancer kg kg >22.7 kg * * * * * P for interaction = * * *p> White African Am Nat Hawaiian Japanese Latina
18 Breast Cancer by BMI & Weight Gain White et al. Int J Cancer >22.7 kg gain Obese * * * * White African Am Nat Hawaiian Japanese Latina Mutually adjusted plus other covariates *p>0.05
19 BMI & Postmenopausal Breast Cancer Risk Author Year Design Categories Risk 95% CI Asians Kuriyama 2005 CC per 5 kg/m , 6.92 Chow 2005 Cohort per 5 kg/m , 2.87 Iwasaki 2007 CC per 5 kg/m , 5.52 Wu 2007 Cohort per 5 kg/m , 1.93 Mathew 2008 Cohort per 5 kg/m , 1.67 Kawaii 2010 CC per 5 kg/m , 5.55 Suzuki 2011 Cohort per 5 kg/m , 1.59 White 2012 Cohort per 5 kg/m , 1.36 Multiple ethnic groups Renehan 2008 Meta per 5 kg/m , 1.19
20 BMI & Postmenopausal Breast Cancer Risk Author Year Design Categories Risk 95% CI Asians Kyogoku 1990 CC Q4 vs Q , 2.40 Hu 1997 CC >24 vs 21.4 kg/m , 4.55 Ng 1997 CC >27.5 vs 21 kg/m , 2.30 Tung 1999 CC >25 vs <20 kg/m , 3.24 Shu 2001 CC >28.0 vs <20.7 kg/m , 3.20 Hirose 2001 Cohort >25 vs <20 kg/m , 2.90 Wu 2006 Cohort >26.2 vs <21.6 kg/m , 1.34 Tian 2007 CC >24.45 vs <24.45 kg/m , 5.68 Suzuki 2013 Cohort 29 vs kg/m , 4.16 Shin 2009 CC >25 vs <20.9 kg/m , 2.20 Multiple ethnic groups Cheraghi 2012 Meta Overweight vs normal , 1.17 Cheraghi 2012 Meta Obese vs normal , 1.34
21 Weight Gain & Postmenopausal Breast Cancer Risk Author Year Design Categories Risk 95% CI Asians Kyogoku 1990 CC >4 kg/m , 2.10 Shu 2001 CC >5.65 vs. <1.15 kg , 4.20 Hirose 2001 Cohort >3 vs 0 kg/m , 1.70 Wu 2007 Cohort >20 vs 10 kg , 4.94 Shin 2009 CC 15 vs 0 kg , 2.40 Kawaii 2010 CC 12 vs <5 kg , 3.45 Suzuki 2011 Cohort 5 kg/m , 1.60 White 2012 Cohort per 5 kg , kg and BMI 24 vs Suzuki 2013 Cohort , 4.42 <10 kg and BMI<24 Multiple ethnic groups ER+/PR , 2.45 Vrieling 2010 Meta ER-/PR , 1.58
22 Waist Hip Ratio & Postmenopausal Breast Cancer Risk Author Year Design Categories Risk 95% CI Asians Ng 1997 CC >0.86 vs <0.75 cm , 14.2 Shu 2001 CC >0.835 vs < cm , 2.50 Wu 2006 Cohort >0.85 vs <77 cm , 1.20 Wu 2007 Cohort >0.84 vs <0.77 cm , 2.15 Mathew 2008 Cohort >0.85 vs <=0.85 cm , 0.97 Shin 2009 CC >0.83 vs <0.77 cm , 2.80 Other ethnic groups Tehard 2006 Cohort Whites , 1.28 Harvie 2007 Meta Multiple , 1.48
23 BMI & Breast Cancer Risk by ER Status Study ER+ ER- RR 95% CI RR 95% CI Iwasaki vs <19 kg/m Suzuki 2009 per 5 kg/m Kawaii vs <18.5 kg/m
24 Premenopausal Breast Cancer Risk Amadou et al. Obesity Reviews 2013 BMI WHR BMI: WHR: 1.05 Asians vs whites 1.19 Asians vs whites
25 Adiposity & Breast Cancer Survival Tao et al. American J Epidemiol, 2005 China DFS <21.23 kg/m % kg/m % 0.90 (0.7, 1.3) kg/m % 1.00 (0.7, 1.4) kg/m % 1.30 (1.0, 1.8) Kwan et al. BMC Cancer, 2012 Japan 25.8 vs 21.2-<23.3 kg/m 2 All 1.46 (0.81, 2.64) ER + or PgR (1.05, 23.4) ER-/PgR (0.38, 2.64) Caan et al. Cancer Epidemiol, Biomarkers & Prev 2012 US&China >10% weight gain US 1.03 (0.84, 1.26) China 1.25 (0.88, 1.77) Chan et al. Ann Oncology 2014 Meta-analysis Overweight 1.11 (1.06, 1.17) Obese 1.35 (1.24, 1.47) Per 5 kg/m (1.12, 1.25)
26 Breast Cancer Survival by Adiposity California Breast Cancer Survivorship Consortium Kwan et al. Am J Epidemiol 2014 BMI White Asian American N HR 95% CI N HR 95% CI Underweight , , 4.10 Normal weight Overweight , , 1.98 Obese , , 2.89 Severely obese , 1.61 Morbidly obese , 2.43 Waist-hip ratio White Asian American N HR 95% CI N HR 95% CI Q1 (<0.763) Q2 (0.763 <0.814) , , 2.83 Q3 (0.814 <0.867) , , 1.93 Q4 ( 0.867) , , 4.03
27 MEC - Breast Cancer-Specific Mortality Conroy et al. Breast Ca Res & Treatment 2011 HR Ethnicity BMI (kg/m 2 ) 2 P = 0.03 P < 0.04 P < Caucasian African Japanese Hawaiian Latino (n=70) American American (n=24) (n=49) (n=83) (n=46) < (n=53) (n=50) (n=81) (n=88) Models adjusted for age at diagnosis, breast cancer subtypes, stage, treatment, and family history of breast caner.
28 MEC - Breast Cancer-Specific Mortality Conroy et al. Breast Ca Res & Treatment Adjusted HR African American P interaction =0.53 Caucasian Japanese American 0.4 Hawaiian < Latino Models adjusted for age at diagnosis, breast cancer subtypes, stage, treatment, and family history of breast cancer.
29 Metabolic Pathways Linking obesity and Breast Cancer Risk Amadou et al. J Oncol 2013 Ethnic differences may exist for several pathways. Figure 5: Metabolic pathways linking obesity and breast cancer risk.
30 Visceral vs. Subcutaneous Fat Lim et al. Nutrition and Diabetes 2011
31 Visceral vs. Subcutaneous Fat Lim et al. Nutrition and Diabetes 2011 Japanese American (n=30) White (n=30) P value Participant Characteristics Age-adjusted mean Age Weight, kg Height, m <.0001 BMI (kg/m 2 ) DXA total fat mass, kg Body Fat Distribution Age- and total fat-adjusted mean DXA trunk-to-periphery fat ratio MRI % subcut fat/abdo area 33.4% 30.2% 0.21 MRI % liver fat (geometric mean) 5.8% 3.8% 0.06 MRI fatty liver (> 5.5%) 51% 24% 0.05
32 Ethnic Differences in Visceral Adipose Tissue : Filipino, White, and AA Women Araneta et al. Obesity 2005
33 Visceral Adipose Tissue in Asians Lear et al. Obesity 2007 VAT at given WC values, adjusted for age, in Europeans (white), Chinese (light gray), and South Asian (dark gray) women
34 Trunk to Periphery Fat Ratio (TPFR) in Mothers by Ethnic Group Morimoto et al. J Epidemiol 2012 p trend <0.01 TPFR p<0.01 p=0.04 p=0.40 Asian Part-Asian Mixed-Other Caucasian
35 Trunk to Periphery Fat Ratio (TPFR) in Daughters by Ethnic Group Morimoto et al. J Epidemiol 2012 p trend <0.001 TPFR p< p=0.02 p=0.01 Asian Part-Asian Mixed-Other Caucasian
36 ng/ml Leptin by Ethnicity and BMI in Premenopausal Women Conroy et al. Mediators of Inflammation 2011 p = < >35 BMI (kg/m 2 ) Caucasian (n=67) l Asian (n=74)
37 Adiponectin by Ethnicity and BMI in Premenopausal Women Conroy et al. Mediators of Inflammation 2011 µg/ml P <0.001 b < > 35 BMI (kg/m 2 ) Caucasian (n=67) l Asian (n=74)
38 Adipokines in Asians vs. White Postmenopausal Women Khan et al. Metabolism Adiponectin HMW ADP Leptin Soluble LR Chinese Japanese P<0.001 for all *Adjusted for age, smoking, waist circumference, physical activity, menopausal status, education
39 Leptin by Ethnicity & BMI Morimoto et al. Int J Obesity 2014 ng/ml p forja =0.01 African American Caucasian (reference) Native Hawaiian Latino 20 Japanese American 10 0 Normal weight Overweight Obese
40 Adiponectin by Ethnicity & BMI Morimoto et al. Int J Obesity 2014 μg/ml 20 p forja < Caucasian (reference) Native Hawaiian Latino African American Japanese American 0 Normal weight Overweight Obese
41 MEC - Adipokines and Breast Cancer Risk Ollberding et al. Ca Prev Res 2013 Quartiles Cases/ Controls Leptin OR (95% CI) Cases/ Controls Adiponectin OR (95% CI) Q1 182/ / Q2 210/176 Q3 158/176 Q4 156/ (0.96, 1.84) 1.74 (1.24, 2.44) 1.78 (1.19, 2.65) 169/ / / (0.87, 1.58) 0.92 (0.67, 1.27) 0.94 (0.66, 1.32) P for trend
42 Adiponectin and Breast Cancer Risk Minatoya et al. Breast Cancer 2013 Adiponectin Cases Controls OR (95% CI) OR (95% CI) < (58.5) 14 (31.1) , < (29.3) 12 (26.7) (12.2) 19 (42.2) 0.61 ( ) 0.15 ( ) 0.34 ( ) 0.06 ( ) P for trend 0.002* 0.001*
43 Conclusions Breast cancer risk and obesity rates have increased in Asians/Asian Americans The associations of BMI, weight gain, and WHR with breast cancer risk appear to be stronger in Asian/Asian Americans than in whites Suggestive evidence for breast cancer survival Obesity-related biomarkers may provide insight into biologic mechanisms; excess fat mass and visceral fat result in low production of adiponectin BMI has many limitations as a measure of adiposity Additional anthropometric measures, in particular from imaging, will be needed to understand the relation between ethnicity and adiposity
44 Acknowledgments MEC Investigators LN Kolonel BE Henderson L Le Marchand LR Wilkens MC Pike Faculty & Postdocs M Goodman SY Park U Lim SM Conroy NJ Ollberding Staff K White Y Morimoto & entire MEC staff The MEC-related research has been supported by many grants: R37 CA54281 (Kolonel) P01 CA (Kolonel) UM1 CA (Le Marchand/Wilkens/Henderson) P01 CA (Le Marchand) R25 CA90956 (Maskarinec) R21 DK (Maskarinec) P30 CA71789 (Carbone)
Type 2 Diabetes in Native Hawaiians according to Admixture: The Multiethnic Cohort
Type 2 Diabetes in Native Hawaiians according to Admixture: The Multiethnic Cohort Gertraud Maskarinec, Yukiko Morimoto, Simone Jacobs, Andrew Grandinetti, Marjorie Mau, Laurence N. Kolonel Prevalence
More informationRacial and Ethnic Disparities in the Impact of Obesity on Breast Cancer Risk and Survival: A Global Perspective 1 3
REVIEW Racial and Ethnic Disparities in the Impact of Obesity on Breast Cancer and Survival: A Global Perspective 1 3 Elisa V Bandera, 4,5 * Gertraud Maskarinec, 6 Isabelle Romieu, 7 and Esther M John
More informationThe Multiethnic Cohort Study: Studying Ethnic Diversity and Cancer. Laurence N. Kolonel, MD, PhD
The Multiethnic Cohort Study: Studying Ethnic Diversity and Cancer Laurence N. Kolonel, MD, PhD Background of the Multiethnic Cohort Study (MEC) Features of the Design Multiethnic: Five groups in Hawaii
More informationElisa V. Bandera, MD, PhD
Elisa V. Bandera, MD, PhD Associate Professor of Epidemiology Rutgers Cancer Institute of New Jersey Rutgers School of Public Health American Institute for Cancer Research Annual Conference on Food, Nutrition,
More informationNIH Public Access Author Manuscript Br J Nutr. Author manuscript; available in PMC 2015 September 28.
NIH Public Access Author Manuscript Published in final edited form as: Br J Nutr. 2014 September 28; 112(6): 976 983. doi:10.1017/s0007114514001780. Dietary isoflavone intake is not statistically significantly
More informationConsideration of Anthropometric Measures in Cancer. S. Lani Park April 24, 2009
Consideration of Anthropometric Measures in Cancer S. Lani Park April 24, 2009 Presentation outline Background in anthropometric measures in cancer Examples of anthropometric measures and investigating
More informationObesity and Breast Cancer Risk in Hispanics: Findings from the Breast Cancer Health Disparities Study
Obesity and Breast Cancer Risk in Hispanics: Findings from the Breast Cancer Health Disparities Study Esther M. John, PhD, MSPH Senior Research Scientist Cancer Prevention Institute of California AICR
More informationGertraud Maskarinec, Ian Pagano, Galina Lurie, Lynne R. Wilkens, and Laurence N. Kolonel
American Journal of Epidemiology Copyright ª 2005 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A. Vol. 162, No. 8 DOI: 10.1093/aje/kwi270 Advance Access publication
More informationCURRICULUM VITAE JASMEET K. GILL
CURRICULUM VITAE JASMEET K. GILL Department of Health Science California State University, Fullerton 800 N. State College Blvd. Fullerton, CA 92834 (657) 278-8657 Jasmeetgill@fullerton.edu EDUCATION: PhD
More informationMeat consumption and risk of type 2 diabetes: the Multiethnic Cohort
Public Health Nutrition: 14(4), 568 574 doi:10.1017/s1368980010002004 Meat consumption and risk of type 2 diabetes: the Multiethnic Cohort A Steinbrecher 1, E Erber 1, A Grandinetti 2, LN Kolonel 1 and
More informationLa obesidad puede matar: el papel de primaria de la salud y la prevención del cáncer.
La obesidad puede matar: el papel de primaria de la salud y la prevención del cáncer. Obesity can kill: the role of primary health and cancer prevention. Luigi Ricciardiello, MD Department of Medical and
More informationResearching Genetic Influences in Different Racial/Ethnic Populations and Cancer
Researching Genetic Influences in Different Racial/Ethnic Populations and Cancer Lenora WM Loo, PhD Assistant Professor (Specialist) University of Hawaii Cancer Center Off-Label Use Disclosure I do not
More informationTITLE: Breast Density Assessment by Dual Energy X-ray Absorptiometry in Women and Girls. Rachel Novotny, Ph.D. Honolulu, HI 96822
AD AWARD NUMBER: W81XWH-07-1-0489 TITLE: Breast Density Assessment by Dual Energy X-ray Absorptiometry in Women and Girls PRINCIPAL INVESTIGATOR: Gertraud Maskarinec, M.D., Ph.D. Rachel Novotny, Ph.D.
More informationChapter 2 The Link Between Obesity and Breast Cancer Risk: Epidemiological Evidence
Chapter 2 The Link Between Obesity and Breast Cancer Risk: Epidemiological Evidence 2.1 BMI and Breast Cancer Risk BMI is routinely used to qualify an individual s adiposity, yet it is simply a measure
More informationDietary Red and Processed Meat Intake and Markers of Adiposity and Inflammation: The Multiethnic Cohort Study
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Nutrition and Health Sciences -- Faculty Publications Nutrition and Health Sciences, Department of 7-2017 Dietary Red and
More informationDietary soy intake and changes of mammographic density in premenopausal Chinese women
Dietary soy intake and changes of mammographic density in premenopausal Chinese women 2010 WCRF International Conference, Nutrition, Physical Activity and Cancer Prevention: Current Challenges, New Horizons
More informationBody size, adult BMI gain and endometrial cancer risk: The multiethnic cohort
Int. J. Cancer: 000, 000 000 (2009) ' 2009 UICC Body size, adult BMI gain and endometrial cancer risk: The multiethnic cohort Sungshim Lani Park 1, Marc T. Goodman 2, Zuo-Feng Zhang 1, Laurence N. Kolonel
More informationSupplementary Figure 1. Principal components analysis of European ancestry in the African American, Native Hawaiian and Latino populations.
Supplementary Figure. Principal components analysis of European ancestry in the African American, Native Hawaiian and Latino populations. a Eigenvector 2.5..5.5. African Americans European Americans e
More informationNIH Public Access Author Manuscript Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2011 September 1.
NIH Public Access Author Manuscript Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 September ; 19(9): 2351 2356. doi: 10.1158/1055-9965.EPI-10-0396. Plasma Coenzyme Q10 levels
More informationORIGINAL REPORTS: LIFESTYLE AND BEHAVIOR CHANGE MEASURES
ORIGINAL REPORTS: LIFESTYLE AND BEHAVIOR CHANGE MEASURES LIFESTYLE RISK FACTORS FOR CHRONIC DISEASE IN A MULTIETHNIC POPULATION: AN ANALYSIS OF TWO PROSPECTIVE STUDIES OVER A 20-YEAR PERIOD Objective:
More informationDiabetes in Asian Americans
Diabetes in Asian Americans www.screenat23.org Winston F. Wong, MD National Council of Asian Pacific Islander Physicians www.ncapip.org American Diabetes Association Joslin Diabetes Center National Council
More informationSupplementary Table 4. Study characteristics and association between OC use and endometrial cancer incidence
Supplementary Table 4. characteristics and association between OC use and endometrial cancer incidence a Details OR b 95% CI Covariates Region Case-control Parslov, 2000 (1) Danish women aged 25 49 yr
More informationBreast Cancer The PRECAMA Study. Dr. Isabelle Romieu Head, Section of Nutrition and Metabolism
Breast Cancer The PRECAMA Study Dr. Isabelle Romieu Head, Section of Nutrition and Metabolism Estimated incidence of breast cancer (2008) Age- standardised rates per 100,000 GLOBOCAN 2008 (globocan.iarc.fr)
More informationAnthropometry: What Can We Measure & What Does It Mean?
Anthropometry: What Can We Measure & What Does It Mean? Anne McTiernan, MD, PhD Fred Hutchinson Cancer Research Center Seattle, Washington, U.S.A. I have no conflicts to disclose. Anthropometry in Human
More informationResearch Article Leptin, Adiponectin, and Obesity among Caucasian and Asian Women
Hindawi Publishing Corporation Mediators of Inflammation Volume 211, Article ID 25358, 7 pages doi:1.1155/211/25358 Research Article Leptin, Adiponectin, and Obesity among Caucasian and Asian Women Shannon
More informationLifestyle Factors and Cancer Survivorship: Observational Findings of Weight, Physical Activity, and Diet on Survival
Lifestyle Factors and Cancer Survivorship: Observational Findings of Weight, Physical Activity, and Diet on Survival Melinda L. Irwin, PhD, MPH Associate Professor of Epidemiology Yale School of Medicine
More informationRoadmap. Diabetes and the Metabolic Syndrome in the Asian Population. Asian. subgroups 8.9. in U.S. (% of total
Diabetes and the Metabolic Syndrome in the Asian Population Alka Kanaya, MD Associate Professor of Medicine, UCSF Feb 26, 2010 Roadmap 1. Diabetes in Asian Americans Prevalence in the U.S. Risk factors
More informationDietary Isoflavone Intake and All-Cause Mortality in Breast Cancer Survivors: The Breast Cancer Family Registry
Original Article Dietary Isoflavone Intake and All-Cause Mortality in Breast Cancer Survivors: The Breast Cancer Family Registry Fang Fang Zhang, MD, PhD 1 ; Danielle E. Haslam, MS 1 ; Mary Beth Terry,
More informationUICC World Cancer Congress Melbourne, Australia 6 December 2014
Ethnic differences, obesity and cancer, stages of the obesity epidemic and cancer prevention Professor TH Lam, JP, BBS MD, FFPH, FFOM, Hon FHKCCM, FHKAM, FRCP Sir Robert Kotewall Professor in Public Health
More informationJackson Heart Study Manuscript Proposal Form
Jackson Heart Study Manuscript Proposal Form Submission Date: 2/15/2017 Proposal ID: P0859 I. TITLE I. Title Information A. Proposal Title: Age related variations in obesity and diabetes correlates in
More informationBreast Cancer: Weight and Exercise. Anne McTiernan, MD, PhD. Fred Hutchinson Cancer Research Center Seattle, WA
Breast Cancer: Weight and Exercise Anne McTiernan, MD, PhD Fred Hutchinson Cancer Research Center Seattle, WA Associations of Obesity with Overall & Breast Cancer Specific Survival Survival Obese vs. Non-obese
More informationCancer Survivors: - Asian Perspective
Cancer Survivors: What we Know, What we Need to Know - Asian Perspective Prof. Josette Sin-yee Chor School of Public Health and Primary Care The Chinese University of Hong Kong Asia Varying incidence of
More informationWAIST-HEIGHT RATIO : A NEW OBESITY INDEX FOR FILIPINOS?
WAIST-HEIGHT RATIO : A NEW OBESITY INDEX FOR FILIPINOS? Consuelo L. Orense, MSPH, Charmaine A. Duante, RMT, MS Epid.(PH), Ermelita N. Bautista, MPH and Lilibeth P. Dasco, MSAN ABSTRACT The study aimed
More informationUMHS-PUHSC JOINT INSTITUTE
Role of Visceral Adiposity in the Pathogenesis of Non-Alcoholic Fatty Liver Disease in Lean versus Obese Patients: A Comparative Study between Patients at UMHS versus PUHSC Lai WEI and Anna LOK W Zhang,
More informationS e c t i o n 4 S e c t i o n4
Section 4 Diet and breast cancer has been investigated extensively, although the overall evidence surrounding the potential relation between dietary factors and breast cancer carcinogenesis has resulted
More informationDietary Fatty acids and Cancer: is there a link?
Dietary Fatty acids and Cancer: is there a link? Veronique Chajes, PhD International Agency for Research on Cancer & Isabelle Romieu, MD, MPH, ScD Instituto Nacional de Salud Publica 1 Declaración de Intereses:
More informationNutrition and gastrointestinal cancer: An update of the epidemiological evidence
Nutrition and gastrointestinal cancer: An update of the epidemiological evidence Krasimira Aleksandrova, PhD MPH Nutrition, Immunity and Metabolsim Start-up Lab Department of Epidemiology German Institute
More informationPopulation: All participants Number of Obs: Variable # Sas Name: Sas Label: Categories: Variable # Sas Name: F80VNUM. Sas Label: Categories:
Form - Last Update: 04/6/001 umber of Obs: 161771 Participant ID 1 ID Participant ID F Days since randomization/enrollment 161771-886 8-59451 516548 FDAYS F Days since randomization/enrollment F Visit
More informationAlona Angosta, PhD, APRN, NP-C University of Nevada, Las Vegas School of Nursing
The Effects of Ballroom Dance on Blood Pressure, Heart Rate, Weight, Waist Circumference, and Body Mass Index among Filipino Americans: A Feasibility Study Alona Angosta, PhD, APRN, NP-C University of
More informationBreast Cancer: Weight and Exercise. Anne McTiernan, MD, PhD. Fred Hutchinson Cancer Research Center Seattle, WA
Breast Cancer: Weight and Exercise Anne McTiernan, MD, PhD Fred Hutchinson Cancer Research Center Seattle, WA Associations of Obesity with Overall & Breast Cancer Specific Survival Survival Obese vs. Non-obese
More informationSupplementary Online Content
Supplementary Online Content The Premenopausal Breast Cancer Collaborative Group. Association body mass index and age with premenopausal breast cancer risk in premenopausal women. JAMA Oncol. Published
More informationType 2 Diabetes in Asian Americans and Screen at 23
Type 2 Diabetes in Asian Americans and Screen at 23 May 16, 2016 Hosted by the Health Committee of the National Council of Asian Pacific Americans www.ncapaonline.org @NCAPAtweets Housekeeping All participants
More informationRisk Factors for Breast Cancer in Elderly Women
American Journal Epidemiology Copyright 2004 by the Johns Hopkins Bloomberg School Public Health All rights reserved Vol. 160, 9 Printed in U.S.A. DOI: 10.1093/aje/kwh276 Risk Factors for Breast Cancer
More informationBody Size and Composition and Risk of Postmenopausal Breast Cancer
Cancer Epidemiology, Biomarkers & Prevention 2117 Body Size and Composition and Risk of Postmenopausal Breast Cancer Robert J. MacInnis, 1 Dallas R. English, 1 Dorota M. Gertig, 2 John L. Hopper, 2 and
More informationCoffee is one of the most widely consumed beverages in the world.
A Newsletter for the Participants of the Multiethnic Cohort Study Multiethnic Cohort Update 24 Years of Epidemiological Research in Cancer Prevention The Multiethnic Cohort Study (MEC), which is being
More information3/25/2010. Age-adjusted incidence rates for coronary heart disease according to body mass index and waist circumference tertiles
Outline Relationships among Regional Adiposity, Physical Activity, and CVD Risk Factors: Preliminary Results from Two Epidemiologic Studies Molly Conroy, MD, MPH Obesity Journal Club February 18, 2010
More informationComparison of Two Instruments for Quantifying Intake of Vitamin and Mineral Supplements: A Brief Questionnaire versus Three 24-Hour Recalls
American Journal of Epidemiology Copyright 2002 by the Johns Hopkins Bloomberg School of Public Health All rights reserved Vol. 156, No. 7 Printed in U.S.A. DOI: 10.1093/aje/kwf097 Comparison of Two Instruments
More informationSoyfood Consumption and Breast Cancer Survival. Xiao Ou Shu, M.D., Ph.D. Ingram Professor of Cancer Research Vanderbilt University, U.S.A.
Soyfood Consumption and Breast Cancer Survival Xiao Ou Shu, M.D., Ph.D. Ingram Professor of Cancer Research Vanderbilt University, U.S.A. Objectives Brief summary of the health benefits of soyfood consumption
More informationESPEN Congress Madrid 2018
ESPEN Congress Madrid 2018 The Role Of Obesity In Cancer Survival And Cancer Recurrence Body Composition And Outcomes In Cancer Patients M-C. Gonzalez (BR) The role of obesity in cancer survival and cancer
More informationObesity, metabolic dysfunction, and the risk of obesity-related cancer
Boston University OpenBU Theses & Dissertations http://open.bu.edu Boston University Theses & Dissertations 2016 Obesity, metabolic dysfunction, and the risk of obesity-related cancer Chadid, Susan https://hdl.handle.net/2144/16734
More informationJapanese, Korean and Chinese subjects had also lived outside their respective countries for less than 10 years.
The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.
More informationAnalysing research on cancer prevention and survival. Diet, nutrition, physical activity and breast cancer survivors. In partnership with
Analysing research on cancer prevention and survival Diet, nutrition, physical activity and breast cancer survivors 2014 In partnership with Contents About World Cancer Research Fund International 1 Our
More informationObesity, Metabolic Syndrome, and Diabetes: Making the Connections
Obesity, Metabolic Syndrome, and Diabetes: Making the Connections Alka M. Kanaya, M.D. Associate Professor of Medicine & Epi/Biostats University of California, San Francisco February 26, 21 Roadmap 1.
More informationNutritional status of breast cancer survivors within first year after diagnosis
UM Breast Cancer Science Café Talk Nutritional status of breast cancer survivors within first year after diagnosis Associate Professor Dr Hazreen Bin Abdul Majid Department of Social and Preventive Medicine,
More informationAppropriate waist circumference cut off level for hypertension screening among admission students at Chiang Mai University
Original article Appropriate waist circumference cut off level for hypertension screening among admission students at Chiang Mai University Lakkana Thaikruea, M.D., Ph.D., 1 Siriboon Yavichai, M.N.S.,
More informationAge 18 years and older BMI 18.5 and < 25 kg/m 2
Quality ID #128 (NQF 0421): Preventive Care and Screening: Body Mass Index (BMI) Screening and Follow-Up Plan National Quality Strategy Domain: Community/Population Health 2018 OPTIONS F INDIVIDUAL MEASURES:
More informationA priori-defined diet quality indexes and risk of type 2 diabetes: the Multiethnic Cohort
Diabetologia (2015) 58:98 112 DOI 10.1007/s00125-014-3404-8 ARTICLE A priori-defined diet quality indexes and risk of type 2 diabetes: the Multiethnic Cohort Simone Jacobs & Brook E. Harmon & Carol J.
More informationAge 18 years and older BMI 18.5 and < 25 kg/m 2
Quality ID #128 (NQF 0421): Preventive Care and Screening: Body Mass Index (BMI) Screening and Follow-Up Plan National Quality Strategy Domain: Community/Population Health 2018 OPTIONS F INDIVIDUAL MEASURES:
More informationWaist circumference and waist/hip ratio in relation to all-cause mortality, cancer and sleep apnea
(2010) 64, 35 41 & 2010 Macmillan Publishers Limited All rights reserved 0954-3007/10 $30 www.nature.com/ejcn REVIEW Waist circumference and waist/hip ratio in relation to all-cause, cancer and sleep apnea
More informationSoyfood Consumption and Breast Cancer Survival. Xiao Ou Shu, M.D., Ph.D. Ingram Professor of Cancer Research Vanderbilt University, U.S.A.
Soyfood Consumption and Breast Cancer Survival Xiao Ou Shu, M.D., Ph.D. Ingram Professor of Cancer Research Vanderbilt University, U.S.A. Objectives Brief summary of the health benefits of soyfood consumption
More informationResearch Article A Matched Case-Control Study of Risk Factors for Breast Cancer Risk in Vietnam
International Breast Cancer Volume 2016, Article ID 7164623, 7 pages http://dx.doi.org/10.1155/2016/7164623 Research Article A Matched Case-Control Study of Risk Factors for Breast Cancer Risk in Vietnam
More informationSurvival of Women with Colon Cancer in Relation to Precancer Anthropometric Characteristics: the Iowa Women's Health Study
Research Article Survival of Women with Colon Cancer in Relation to Precancer Anthropometric Characteristics: the Iowa Women's Health Study Cancer Epidemiology, Biomarkers & Prevention Anna E. Prizment
More information# % & (!) +,. / !( : 0 ( (;9 +/ ((8
! # % & (!) +,. / 0 1 2 3 4 + 5.667 8 19!( : 0 ( (;9 +/ ((8 < Do we need to think beyond BMI for estimating population level health risks? Green, MA (Corresponding author), Research Associate, School of
More informationUC Office of the President Recent Work
UC Office of the President Recent Work Title The California Breast Cancer Survivorship Consortium (CBCSC): prognostic factors associated with racial/ethnic differences in breast cancer survival Permalink
More informationVariability of the Nutrient Composition of Multivitamin Supplements
3th National Nutrient Databank Conference Variability of the Nutrient Composition of Multivitamin Supplements Song-Yi Park, PhD Suzanne P. Murphy, PhD, RD Donna Au, MPH, RD Laurence N. Kolonel, MD, PhD
More informationImplementing Type 2 Diabetes Prevention Programmes
Implementing Type 2 Diabetes Prevention Programmes Jaakko Tuomilehto Department of Public Health University of Helsinki Helsinki, Finland FIN-D2D Survey 2004 Prevalence of previously diagnosed and screen-detected
More informationThe Role of Observational Studies. Edward Giovannucci, MD, ScD Departments of Nutrition and Epidemiology
The Role of Observational Studies Edward Giovannucci, MD, ScD Departments of Nutrition and Epidemiology Disclosure Information As required, I would like to report that I have no financial relationships
More informationINVESTIGATING METABOLICALLY HEALTHY OBESITY IN US MINORITY POPULATIONS: THE IRAS FAMILY STUDY XANTHIA SAMAROPOULOS
INVESTIGATING METABOLICALLY HEALTHY OBESITY IN US MINORITY POPULATIONS: THE IRAS FAMILY STUDY BY XANTHIA SAMAROPOULOS A Thesis Submitted to the Graduate Faculty of WAKE FOREST UNIVERSITY GRADUATE SCHOOL
More informationRacial/Ethnic Differences in Postmenopausal Endogenous Hormones: The Multiethnic Cohort Study
1849 Racial/Ethnic Differences in Postmenopausal Endogenous Hormones: The Multiethnic Cohort Study Veronica Wendy Setiawan, 1 Christopher A. Haiman, 1 Frank Z. Stanczyk, 2 Loïc Le Marchand, 3 and Brian
More informationHHS Public Access Author manuscript Eur J Clin Nutr. Author manuscript; available in PMC 2017 September 01.
Ethnic Admixture Affects Diabetes Risk in Native Hawaiians: The Multiethnic Cohort Gertraud Maskarinec 1, Yukiko Morimoto 1, Simone Jacobs 2, Andrew Grandinetti 3, Marjorie K. Mau 4, and Laurence N. Kolonel
More informationHigh Fiber and Low Starch Intakes Are Associated with Circulating Intermediate Biomarkers of Type 2 Diabetes among Women 1 3
The Journal of Nutrition Nutritional Epidemiology High Fiber and Low Starch Intakes Are Associated with Circulating Intermediate Biomarkers of Type 2 Diabetes among Women 1 3 Hala B AlEssa, 4 Sylvia H
More informationObesity in South Korea
Obesity in South Korea Nah-Mee Shin, Ph.D, Assistant Professor, APRN, BC (Nurse Practitioner) Korea University, College of Nursing 1 To get to know South Korea Geography: area: 98,477 sq.km. (38,022 sq.mi.);
More informationAnalysing research on cancer prevention and survival. Diet, nutrition, physical activity and breast cancer survivors. Revised 2018
Analysing research on cancer prevention and survival Diet, nutrition, physical activity and breast cancer survivors 2014 Revised 2018 Contents World Cancer Research Fund Network 3 1. Summary of Panel judgements
More informationObesity, diabetes mellitus, and the risk of female breast cancer in Eastern China
Wang et al. World Journal of Surgical Oncology 2013, 11:71 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Obesity, diabetes mellitus, and the risk of female breast cancer in Eastern China Xiao-Lei
More informationObesity, waist size and prevalence of current asthma in the California Teachers Study cohort
1 Northern California Cancer Center, Berkeley and Fremont, California, USA; 2 Environmental Health Investigations Branch, California Department of Public Health, Richmond, California, USA; 3 Department
More informationThe Oncologist 2017;22: ABSTRACT. Breast Cancer
Breast Cancer Distinct Effects of Body Mass Index and Waist/Hip Ratio on Risk of Breast Cancer by Joint Estrogen and Progestogen Receptor Status: Results from a Case-Control Study in Northern and Eastern
More informationLetter to the Editor. Association of TCF7L2 and GCG Gene Variants with Insulin Secretion, Insulin Resistance, and Obesity in New-onset Diabetes *
814 Biomed Environ Sci, 2016; 29(11): 814-817 Letter to the Editor Association of TCF7L2 and GCG Gene Variants with Insulin Secretion, Insulin Resistance, and Obesity in New-onset Diabetes * ZHANG Lu 1,^,
More informationLeveraging Prospective Cohort Studies to Advance Colorectal Cancer Prevention, Treatment and Biology
Leveraging Prospective Cohort Studies to Advance Colorectal Cancer Prevention, Treatment and Biology Charles S. Fuchs, MD, MPH Director, Yale Cancer Center Physician-in-Chief, Smilow Cancer Hospital New
More informationDevelopment of a Supplement Composition Database for the SURE Study. Kim Yonemori,, Suzanne Murphy, Yukiko Morimoto, Lynne Wilkens
Development of a Supplement Composition Database for the SURE Study Kim Yonemori,, Suzanne Murphy, Yukiko Morimoto, Lynne Wilkens Overview The SURE Study The Cancer Research Center of Hawaii s dietary
More informationLeveraging Clinical Databases for Epidemiologic (Population) Research. The Pan Asian Cohort Study (PACS) at the Palo Alto Medical Foundation (PAMF)
Leveraging Clinical Databases for Epidemiologic (Population) Research The Pan Asian Cohort Study (PACS) at the Palo Alto Medical Foundation (PAMF) Palo Alto Medical Foundation (PAMF) San Francisco Bay
More informationMetabolic Syndrome in Asians
Metabolic Syndrome in Asians Alka Kanaya, MD Asst. Professor of Medicine, UCSF Asian CV Symposium, November 17, 2007 The Metabolic Syndrome Also known as: Syndrome X Insulin Resistance Syndrome The Deadly
More informationA THESIS SUBMITTED TO THE GRADUATE DIVISION OF THE UNIVERSITY OF HAWAI I AT MĀNOA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF
Are World Cancer Research Fund and American Institute for Cancer Research Recommendations for Cancer Prevention Associated with Known Chronic Disease Biomarkers in Healthy Women? A THESIS SUBMITTED TO
More informationA Multiethnic Cohort in Hawaii and Los Angeles: Baseline Characteristics
Journal of Epidemiology Copyright 2000 by The Johns Hopkins University School of Hygiene and Public Health All rights reserved Vol. 151, No. 4 Printed in U.S.A. ORIGINAL CONTRIBUTIONS A Multiethnic Cohort
More informationPhysical activity, Obesity, Diet and Colorectal Cancer Prognosis. Jeffrey Meyerhardt, MD, MPH Dana-Farber Cancer Institute Boston, MA
Physical activity, Obesity, Diet and Colorectal Cancer Prognosis Jeffrey Meyerhardt, MD, MPH Dana-Farber Cancer Institute Boston, MA Colorectal Cancer Incidence ~148,000 cases in US annually and ~50,000
More informationNo effect of exercise on insulin-like growth factor (IGF)-1, insulin and glucose in young women participating in a 16-week randomized controlled trial
University of North Florida UNF Digital Commons Nutrition and Dietetics Faculty Publications Department of Nutrition and Dietetics 11-2010 No effect of exercise on insulin-like growth factor (IGF)-1, insulin
More informationDisclosers: No conflict
Obesity, the Obesity Paradox and Cancer Disparities Hisham Hussan M.D. Assistant Professor of Clinical Medicine Director: Section of Obesity and Bariatric Endoscopy Section of Intestinal Neoplasia and
More informationSalt, soft drinks & obesity Dr. Feng He
Salt, soft drinks & obesity Dr. Feng He Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK f.he@qmul.ac.uk BP Salt CVD Obesity
More informationMISSING IN ACTION : Ethnic Groups in Cancer Screening
MISSING IN ACTION : Ethnic Groups in Cancer Screening Annette E. Maxwell, Dr.P.H. Division of Cancer Prevention and Control Research Jonsson Comprehensive Cancer Center University of California, Los Angeles
More informationWeight gain affects prostate cancer risk
Weight gain affects prostate cancer risk Obesity is well-known to increase the risk of colon and breast cancer. However, it can also seriously impact men s prostate cancer risk, claims a new study conducted
More informationThe Multiethnic Cohort Study
VOL. 13 ISSUE 1 FALL 2013 Multiethnic Cohort Update The Multiethnic Cohort Study (MEC) celebrates 20 years of ground-breaking research thanks to all of you who completed our surveys. It s hard to believe
More informationNutrition and Physical Activity Cancer Prevention Guidelines and Cancer Prevention
Nutrition and Physical Activity Cancer Prevention Guidelines and Cancer Prevention Ana Maria Lopez, MD, MPH, FACP Professor of Medicine and Pathology University of Arizona Cancer Center Medical Director,
More informationBody size and thyroid nodules in healthy Korean population
J Korean Surg Soc 2012;82:13-17 http://dx.doi.org/10.4174/jkss.2012.82.1.13 ORIGINAL ARTICLE JKSS Journal of the Korean Surgical Society pissn 2233-7903 ㆍ eissn 2093-0488 Body size and thyroid nodules
More informationDeaths in Hawaii Due to Major Cardiovascular Disease
in Hawaii Due to Major Cardiovascular Disease Death Counts, Age-Adjusted Mortality Rates, and Years of Potential Life Lost for Coronary Heart Disease for the State of Hawaii (Residents Only), by State,
More informationDiagnostic Test of Fat Location Indices and BMI for Detecting Markers of Metabolic Syndrome in Children
Diagnostic Test of Fat Location Indices and BMI for Detecting Markers of Metabolic Syndrome in Children Adegboye ARA; Andersen LB; Froberg K; Heitmann BL Postdoctoral researcher, Copenhagen, Denmark Research
More informationMedical risk reducing strategies for breast cancer
Medical risk reducing strategies for breast cancer PROF. DR. H. DEPYPERE Menopause Clinic, University Hospital, Ghent, Belgium Life expectancy in Belgium 46,6 y in 1880 and 83,8 y in 2014 2 Women Men Aantal
More informationRESEARCH. Dagfinn Aune, 1,2 Abhijit Sen, 1 Manya Prasad, 3 Teresa Norat, 2 Imre Janszky, 1 Serena Tonstad, 3 Pål Romundstad, 1 Lars J Vatten 1
open access BMI and all cause mortality: systematic review and non-linear dose-response meta-analysis of 230 cohort studies with 3.74 million deaths among 30.3 million participants Dagfinn Aune, 1,2 Abhijit
More informationCurrent status on other health effects:
Current status on other health effects: Changes in Cardiovascular Risk Factors after the Great East Japan Earthquake Tetsuya Ohira, MD, PhD. Department of Epidemiology, Fukushima Medical University School
More informationPublished OnlineFirst May 25, 2010; DOI: / EPI Published OnlineFirst on May 25, 2010 as /
Published OnlineFirst on May 25, 2010 as 10.1158/1055-9965.EPI-10-0171 Research Article Association of Anthropometric Characteristics with the Risk of Malignant Lymphoma and Plasma Cell Myeloma in a Japanese
More information