MATERIAL SAFETY DATA SHEET

Transcription

1 Page 1 of 7 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Pfizer Consumer Healthcare Pfizer Inc 201 Tabor Road Morris Plains, NJ Emergency telephone number: Hours of Operation - 24 Hours: CHEMTREC (24 hours): Pfizer Ltd Ramsgate Road Sandwich, Kent CT13 9NJ United Kingdom (0) Emergency telephone number: ChemSafe (24 hours): +44 (0) Trade Name: Chemical Family: Intended Use: LISTERINE Mixture mouthwash 2. COMPOSITION/INFORMATION ON INGREDIENTS Hazardous Ingredient CAS Number EU EINECS List % Thymol Methyl salicylate Menthol Benzoic Acid * Ingredient CAS Number EU EINECS List % Eucalyptol Water >50 Flavor NOT ASSIGNED Not listed * Sorbitol solution * * Poloxamer Not listed * Cochineal extract * Sucralose * Additional Information: * Proprietary Ingredient(s) indicated as hazardous have been assessed under standards for workplace safety. 3. HAZARDS IDENTIFICATION Appearance: Signal Word: Clear orange liquid WARNING

2 Page 2 of 7 Statement of Hazard: Additional Hazard Information: Short Term: Long Term: EU Indication of danger: EU Hazard Symbols: Flammable liquid and vapor. May cause eye irritation May cause respiratory irritation. This product contains ethanol which can cause liver changes, central nervous system effects, and birth defects in the developing fetus An Occupational Exposure Limit has been established for one or more of the ingredients (see Section 8). Chronic ingestion of ethanol has been associated with an increased incidence of cancer, liver cirrhosis, and, if ingested during pregnancy, congenital malformations. Irritant EU Risk Phrases: R10 - Flammable. R36 - Irritating to eyes. Additional Information: For a more detailed discussion of potential health hazards and toxicity see Section 11. Note: This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the product or its ingredients regardless of the potential risk. The precautionary statements and warnings included may not apply in all cases. Your needs may vary depending upon the potential for exposure in your workplace. 4. FIRST AID MEASURES Eye Contact: Skin Contact: Ingestion: Inhalation: Immediately flush eyes with water for at least 15 minutes. If irritation occurs or persists, get medical attention. Wash skin with soap and water. Remove contaminated clothing and shoes. This material may not be completely removed by conventional laundering. Consult professional laundry service. Do not home launder. If irritation occurs or persists, get medical attention. Do not induce vomiting unless directed by medical personnel. Never give anything by mouth to an unconscious person. Seek medical assistance if symptoms occur or persist. Remove to fresh air. If discomfort persists, get medical attention. 5. FIRE FIGHTING MEASURES Extinguishing Media: Hazardous Combustion Products: Fire Fighting Procedures: Fire / Explosion Hazards: Additional Information: Use carbon dioxide, sand, extinguishing powder. Do not use water. Emits fumes of carbon monoxide, nitrogen oxides, and hydrogen cyanide. Wear approved positive pressure, self-contained breathing apparatus and full protective turn out gear. Flammable liquid. Vapors are heavier than air and may travel along surfaces to remote ignition sources and flash back. Vapors may form explosive mixture with air.

3 Page 3 of 7 6. ACCIDENTAL RELEASE MEASURES Health and Safety Precautions: Measures for Cleaning / Collecting: Measures for Environmental Protections: Additional Consideration for Large Spills: Personnel involved in clean-up should wear appropriate personal protective equipment (see Section 8). Minimize exposure. Use non-combustible absorbent material to wipe up spill and place in a sealed container for disposal. Clean spill area thoroughly. Place waste in an appropriately labeled, sealed container for disposal. Care should be taken to avoid environmental release. Contain the source of the spill or leak if it is safe to do so. Transfer all waste to a labeled container and move it to a secure holding area. 7. HANDLING AND STORAGE General Handling: Storage Conditions: Storage Temperature: Use adequate ventilation. Avoid contact with skin and clothing. Avoid breathing vapor or mist. Keep container tightly closed when not in use. Store in a cool, dry, well-ventilated area. Keep away from heat, sparks, flame, and other sources of ignition F 8. EXPOSURE CONTROLS / PERSONAL PROTECTION OSHA - Final PELS - TWAs: ACGIH Threshold Limit Value (TWA) 1000 ppm 1900 mg/m³ 1000 ppm TWA Engineering Controls: Good general ventilation should be sufficient to control airborne levels. Local and general ventilation should be used as necessary, when handling this material in bulk. Personal Protective Equipment: Hands: Eyes: Skin: Respiratory protection: Chemical protective gloves Safety glasses or goggles Wear protective clothing when working with large quantities. None required under normal conditions of use. If the applicable Occupational Exposure Limit (OEL) is exceeded, wear an appropriate respirator with a protection factor sufficient to control exposures to below the OEL. 9. PHYSICAL AND CHEMICAL PROPERTIES: Physical State: Liquid Color: Orange Odor: Characteristic Molecular Formula: Mixture Molecular Weight: Mixture Solvent Solubility: Soluble: Alcohol Solubility: Soluble: Water ph: 4.2 (20 C) Flash Point ( C): 33 Specific Gravity: 1.02

4 Page 4 of STABILITY AND REACTIVITY Stability: Conditions to Avoid: Incompatible Materials: Polymerization: Stable Eliminate possible ignition sources (e.g., heat, sparks, flame, impact, friction, electrostatic discharge). Strong oxidizing agents and strong inorganic acids Will not occur 11. TOXICOLOGICAL INFORMATION General Information: There are no data for this formulation. The information included in this section describes the potential hazards of the individual ingredients. Acute Toxicity: (Species, Route, End Point, Dose) Mouse Oral LD50 3,450 g/m 3 Rat Oral LD50 7,060 mg/kg Mouse Inhalation LC50 4h 39 g/m 3 Rat Inhalation LC50 10h 20,000 mg/kg Sorbitol solution Rat Oral LD50 15,900 mg/kg Mouse Oral LD50 17,800 mg/kg Benzoic Acid Rat Oral LD mg/kg Rat Oral LD mg/kg Rat Oral LD50 4,070 mg/kg Mouse Oral LD mg/kg Menthol Rat Oral LD mg/kg Rabbit Dermal LD50 > 5000 mg/kg Thymol Rat Oral LD mg/kg Mouse Oral LD mg/kg Guinea Pig Oral LD mg/kg Mouse IV LD mg/kg Methyl salicylate Rat Oral LD mg/kg Guinea Pig Dermal LD ml/kg Rabbit Dermal LD50 > 5000 mg/kg Eucalyptol Rat Oral LD mg/kg Acute Toxicity Comments: A greater than symbol (>) indicates that the toxicity endpoint being tested was not achievable at the highest dose used in the test. Irritation / Sensitization: (Study Type, Species, Severity)

5 Page 5 of 7 Eye Irritation Rabbit Severe Benzoic Acid Skin Irritation Rabbit Mild Eye Irritation Rabbit Severe Menthol Eye Irritation Rabbit Severe Thymol Skin Irritation Rabbit Corrosive Methyl salicylate Eye Irritation Guinea Pig Severe Skin Irritation Guinea Pig Severe Repeated Dose Toxicity: (Duration, Species, Route, Dose, End Point, Target Organ) 10 Day(s) Rat Oral mg/kg LOAEL Liver, Blood 10 Day(s) Mouse Oral 45 g/kg LOAEL Liver, Kidney, Blood, Ureter, Bladder Reproduction & Developmental Toxicity: (Study Type, Species, Route, Dose, End Point, Effect(s)) Embryo / Fetal Development Rat Oral 44 g/kg LOEL Developmental toxicity Carcinogen Status: None of the components of this formulation are listed as a carcinogen by IARC, NTP or OSHA. 12. ECOLOGICAL INFORMATION Environmental Overview: The environmental characteristics of this material have not been fully evaluated. Releases to the environment should be avoided. Aquatic Toxicity: (Species, Method, End Point, Duration, Result) Fingerling Trout NPDES LC50 24 Hours 11,200 mg/l Rainbow Trout NPDES LC50 96 Hours 12,900 mg/l Fathead minnow NPDES LC50 96 Hours 14,200 mg/l 13. DISPOSAL CONSIDERATIONS Disposal Procedures: Observe all local and national regulations when disposing of this material. 14. TRANSPORT INFORMATION

6 Page 6 of 7 Aqueous products containing alcohol at 24 percent or less are not subject to the requirements of the EU ADR, IATA, or IMDG. They are similarly exempt from US DOT requirements provided that they contain no less than 50 percent water. 15. REGULATORY INFORMATION EU Labeling: EU Indication of danger: EU Risk Phrases: EU Safety Phrases: Xi Irritant R10 - Flammable. R36 - Irritating to eyes. S7 - Keep container tightly closed. S16 - Keep away from sources of ignition - No smoking. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. OSHA Label: WARNING Flammable liquid and vapor. May cause eye irritation May cause respiratory irritation. This product contains ethanol which can cause liver changes, central nervous system effects, and birth defects in the developing fetus Canada - WHMIS: Classifications WHMIS hazard class: Class B, Division 2 Class D, Division 2, Subdivision B Thymol EU EINECS List Eucalyptol EU EINECS List Methyl salicylate EU EINECS List Menthol EU EINECS List California Proposition 65 developmental toxicity, initial date 10/1/87 (when in alcoholic beverages)

7 Page 7 of 7 EU EINECS List Water EU EINECS List Sorbitol solution EU EINECS List Benzoic Acid CERCLA/SARA Hazardous Substances 2270 kg final RQ and their Reportable Quantities: 5000 lb final RQ EU EINECS List EU EINECS List Poloxamer 407 Cochineal extract EU EINECS List Sucralose EU EINECS List OTHER INFORMATION Prepared by: Corporate Occupational Toxicology & Hazard Assessment Pfizer Inc believes that the information contained in this Material Safety Data Sheet is accurate, and while it is provided in good faith, it is without a warranty of any kind, expressed or implied. End of Safety Data Sheet