Theme Topics Subtopics. Basic and Translational Science. Development of New Models and Analysis Methods
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1 Basic and Translational Science Development of New Models and Analysis Methods α-synuclein Amyloid/Abeta Behavioral models Inflammation Novel assays and technologies Screening studies/platforms Seeding and spreading of proteinopathies Tau TDP-43 Validation of pre-clinical methods Genetics Blood-borne markers of CNS disease Endophenotypes Epigenetics Genetic factors of Alzheimer s disease Genetic factors of non-alzheimer s tauopathies Genetics of cognitive aging Molecular and cell biology α-synuclein β-amyloidosis APP/Abeta/Amyloid Axonal transport Calcium homeostasis Cell cycle disruption Endosomal-lysosomal dysfunction Enzyme activities Inflammation Mitochondrial function/energetics Neurodegeneration and Neuroprotection
2 Protein-Protein interactions Neurofibrillary degeneration Neuronal cell death mechanisms (i.e. apoptosis) Neurotrophin mechanisms Others Oxidative stress Presenilins Protein clearance/recycling Receptors Signal transduction Stem Cells, IPS cells Synaptic disruption Tau TDP-43 Vascular factors No subtopics Diagnosis and Prognosis Biomarkers (nonneuroimaging) Differential diagnosis Longitudinal change over time Method development and/or quality control Multi-modal comparisons Novel biomarkers Plasma/serum/urine biomarkers Prognostic utility Use in clinical trial design and evaluation
3 Clinical (neuropsychiatry and behavioral neurology) Assessment/measurement of neuropsychiatric/behavioral and psychological symptoms Behavioral neurology Cross-cultural issues Dementia Mild cognitive impairment/early symptomatic disease Neuropsychiatry Non-pharmacologic interventions Normal cognitive aging, including oldest old Presymptomatic disease/prodromal disease/prodromal states Symptom clusters and syndromes Treatment development and clinical trials Neuroimaging Animal imaging Differential diagnosis Evaluating treatments Imaging and genetics Multi-modal comparisons New imaging methods Normal brain aging Neuropathology Alpha-synuclein Optimal neuroimaging measures for early detection Optimal neuroimaging measures for tracking disease progression Amyloid Etiopathogenesis--links to brain disease
4 Novel methods Other Proteinopathies Selective vulnerability Tau Topography of pathology Vascular Neuropsychology Computerized neuropsychological assessment Early detection of cognitive decline with neuropsychological tests Multicultural issues in assessment of dementia Neuropsychological correlates of physiologic markers of cognitive decline/dementia Neuropsychological profiles of dementia: Valid biomarkers? Normal cognitive aging Public Health and Psychosocial Dementia Care Practice Innovative programs and practices Leadership and staff development Policy and systems change Program evaluation and care interventions Epidemiology Epidemiology of MCI and dementia Epidemiology of risk factors of Alzheimer's or all-cause dementia Epidemiology of risk factors of vascular dementia or other dementias
5 Health Economics and Policy Psychosocial and Environmental Prevention (primary or secondary) Cost of care Policy and plans Services Assessment and care planning Behavioral interventions Environmental design and technology Family/lay caregiving Instrument development, program evaluation and translation Living with dementia and quality of life Long-term and community care Prevention (primary or secondary) Therapeutic strategies and interventions Therapeutics Clinical Ethical issues Human trials: Cognitive enhancement Human trials: Nutraceuticals and nonpharmacological interventions Human trials: Other behavioral symptoms Human trials: Anti-amyloid Human trials: Anti-tau Human trials: Inflammation Human trials: Other Novel outcomes measures Trial design
6 Preclinical Lead optimization studies Natural products and nutraceuticals Non-pharmacological interventions Novel screening strategies studies: Amyloid studies: Cognitive enhancement and other behavioral symptoms studies: Inflammation and innate immunity studies: Mitochondria and neuroprotection studies: Other studies: Proteostasis studies: Tau
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