TITLE: Development of a Blood-Based Biomarker Panel for Indeterminate Lung Nodules
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1 Award Number: W81XWH TITLE: Development of a Blood-Based Biomarker Panel for Indeterminate Lung Nodules PRINCIPAL INVESTIGATOR: Ayumu Taguchi CONTRACTING ORGANIZATION: University of Texas MD Anderson Cancer Center Houston, TX REPORT DATE: September 2016 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland DISTRIBUTION STATEMENT: Approved for Public Release; Distribution Unlimited The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.
2 REPORT DOCUMENTATION PAGE Form Approved OMB No Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports ( ), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE September REPORT TYPE Annual 3. DATES COVERED 1 Sep Aug TITLE AND SUBTITLE 5a. CONTRACT NUMBER Development of a Blood-Based Biomarker Panel for Indeterminate Lung Nodules 6. AUTHOR(S) Ayumu Taguchi 5b. GRANT NUMBER W81XWH c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER ATaguchi@mdanderson.org 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER University of Texas MD Anderson Cancer Center Rene Gonzales 1515 Holcombe Blvd Unit 207 Houston TX SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland SPONSOR/MONITOR S REPORT NUMBER(S) 12. DISTRIBUTION / AVAILABILITY STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Lung cancer screening with low-dose CT (LDCT) has been shown to reduce mortality by 20%, although there are concerns including high false positivity, cost, and radiation exposure. Blood-based markers are a promising and attractive approach to complement LDCT because of the potential to identify those subjects that need to undergo further work-up for their indeterminate nodules. The main objective of my proposed project is to develop a blood-based biomarker panel from three platforms (protein, autoantibody and microrna) to distinguish malignant lung nodules from benign lung nodules. We have so far assayed 20 protein markers, 122 autoantibodies, 20 micrornas, and a metabolite DAS, in the 149 malignant lung nodules and 187 benign lung nodules. Though preliminary, the combined panel yielded AUC of 0.838, which was significantly higher than the AUC of pro-sftpb and DAS (AUC = 0.722, P = ), suggesting potential usefulness of our biomarker panel in interpretation of indeterminate lung nodules. During the next period, we will develop and validate a biomarker panel for nodule diagnosis with integrating LDCT imaging. Assuming a prevalence of malignant nodule 3.6% as observed in NLST trial leads to specificity 35% for non-malignant nodules subjects, sparing 1/3 of unnecessary work-ups with high confidence that they are indeed lung cancer free. 15. SUBJECT TERMS Nothing listed 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT a. REPORT b. ABSTRACT c. THIS PAGE Unclassified Unclassified Unclassified Unclassified 18. NUMBER OF PAGES 8 19a. NAME OF RESPONSIBLE PERSON USAMRMC 19b. TELEPHONE NUMBER (include area code) Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39.18
3 TABLE OF CONTENTS Page 1. Introduction Keywords Accomplishments Impact Changes/ Problems Products Participants & Other Collaborating Organizations 7 8. Special Reporting Requirements 8 9. Appendices 8
4 1. Introduction Lung cancer screening with low-dose CT (LDCT) has been shown to reduce mortality by 20%, although there are concerns including high false positivity, cost, and radiation exposure. Bloodbased markers are a promising and attractive approach to complement LDCT because of the potential to identify those subjects that need to undergo further work-up for their indeterminate nodules. We have identified through a series of discovery and initial validation studies, a set of protein and autoantibody biomarkers with potential for early detection. In this proposed study, we will integrate circulating micrornas, which have recently emerged as additional promising biomarkers for lung cancer, with our protein and autoantibody biomarkers and develop a bloodbased biomarker panel to reduce unnecessary and invasive work-up by determining among screened subjects those individuals with lung nodules who would need or would not need further diagnostic work-up, and consequently to reduce mortality associated with lung cancer through more effective screening strategies. 2. Keywords Lung cancer, diagnosis, biomarker, protein, autoantibody, microrna, low-dose CT screening 3. Accomplishments Major goals Major goals #1: protein, autoantibody and microrna profiling of plasmas from subjects with malignant lung nodules and subjects with benign nodules from the PanCan set. Milestones: IRB/HRPO approval (1-5 months): 100% Profiling of protein, autoantibody and microrna markers in the PanCan set (6-10 months): 100% Major goal #2: selection of biomarkers and development of an optimal model in the PanCan set. Milestone: Development of an optimal model in the PanCan set (11-13 months): 50% Accomplishment The main objective of my proposed project is to develop a blood-based biomarker panel from three platforms (protein, autoantibody and microrna) in samples collected in a screening setting from the Pan-Canadian Early Detection of Lung Cancer Study (PanCan) and test the marker combination in an independent screening cohort, the German Lung Cancer Screening Intervention Trial (LUSI), to distinguish malignant lung nodules from benign lung nodules. The markers from the three platforms will be subjected to model building and the added benefit of combining across platforms will be scrutinized. An optimal model will be built, integrating known lung cancer risk factors, findings from LDCT. For the proposed studies, we have obtained access to sets of samples from two independent cohorts: The Pan-Canadian Early Detection of Lung Cancer Study (PanCan) and The 4
5 German Lung Cancer Screening Intervention Trial (LUSI). In addition to these samples, we recently obtained access to additional set of plasma samples from the UT Southwestern in collaboration with Dr. Adi Gazdar, consisting of 52 malignant lung nodules and 35 benign lung nodules (the UTSW set). These additional samples will provide us further opportunities to refine and validate our biomarker panel. We have so far assayed 20 protein markers, 122 autoantibodies, 20 micrornas, and a metabolite DAS, which we recently identified as a prediagnostic lung cancer biomarker (Wikoff et al. JCO 2015), in the 115 malignant lung nodules and 196 benign lung nodules in the UTSW and PanCan sets for nodule diagnosis (Table 1). While we are still blinded to the results of PanCan samples and we have not finalized panel development, we preliminarily examined if combination of biomarkers would improve the performance of pro-sftpb and DAS in discriminating malignant lung nodules from benign lung nodules. The combined panel yielded AUC of 0.838, which was significantly higher than the AUC of pro-sftpb and DAS (AUC = 0.722, P = ) in the UTSW set (Figure 1), suggesting potential usefulness of our biomarker panel in interpretation of indeterminate lung nodules. Table 1. Characteristics of subjects. UTSW set PanCan set Total (n) Sex (male/female) 47/40 107/117 Smoking status (Current/Former/Never) 55/24/8 80/125/19 Nodule (malignant/benign) 52/35 63/161 Figure 1. Performance of combined biomarker panel in the UTSW set. 5
6 Opportunities for training and professional development The proposed project provided me an excellent opportunity to present our biomarker studies at the Interdisciplinary Translational Education and Research Training Program (ITERT), which the Department of Translational Molecular Pathology (TMP) has offered at MD Anderson Cancer Center since ITERT is a multidisciplinary training program for graduate students, postdoctoral and M.D. fellows, aiming 1) to provide a broad and comprehensive education covering timely concepts in translational cancer research, including risk factors, early detection, molecular-targeted therapy, disease monitoring and mechanism of recurrence, as well as computational and systems biology; and 2) to provide an innovative environment, infrastructure, faculty, career-, and administrative support to allow trainees to develop innovative translational cancer research skills; and 3) to promote a sense of community and an interactive research and educational environment among trainees and faculty in the TMP. Opportunities for training and professional development provided to people who worked on the project. A postdoctoral fellow (Dr. Tanaka) and a research assistant (Ms. Gargy) are working on this project. Through one-on-one training as well as technical seminars, they improved their skills including protein and autoantibody assay development, analytical assessment of the assays, isolation and assay of microrna, and statistical analysis of biomarker candidates. Dissemination of the results to communities Plan in the next reporting period During the next period, we will develop and validate a biomarker panel for nodule diagnosis with integrating LDCT imaging. To increase the number of samples, the assay results of UTSW and PanCan set will be standardized and combined. Biomarker panel will be developed with integrating clinical factors and findings from LDCT imaging. Then we will adjust its threshold to correspond to 98% sensitivity for malignant nodules and test its specificity against benign nodules. The biomarker/imaging panel will be tested in the LUSI set. Regarding LDCT imaging, volumetric analysis and textural analysis of lung nodules will be performed to help distinguish benign from the malignant lung nodules, in collaboration with the expert radiologists Drs. Jeremy Erasmus and Myrna Godoy at MDACC. Since we aim at rule out low risk people from invasive/expensive work-up they otherwise would be subjected to by current medical practice, the decision role will require a high sensitivity for true positive nodules, i.e. lung cancer, and a NPV for people whose biomarker value is below threshold. Therefore Major Goal #3 is to validate a threshold from a biomarker/imaging panel that has NPV > 99.8%, sensitivity 98% in the LUSI set. Assuming a prevalence of malignant nodule 3.6% as observed in NLST trial leads to specificity 35% for non-malignant nodules subjects, sparing 1/3 of unnecessary work-ups with high confidence that they are indeed lung cancer free. 6
7 4. Impact Distinctive contributions, major accomplishments, innovations, successes, or any change in practice or behavior that has come about as a result of the project Although a large number of lung cancer biomarker studies have been published, the vast majority of lung cancer biomarker studies consist of one type of biomarkers being evaluated, whether consisting of circulating proteins, autoantibodies, micrornas or other types without an appreciation of their performance relative to other markers. Therefore there is the need to assess and compare the relative contribution of different biomarkers and assay platforms side by side using the same sample sets, in order to determine their comparative performance and the contribution of individual markers to a robust panel. Although it is still preliminary and need to be validated in an independent sample set, our blood-based biomarker panel integrating protein, autoantibody, microrna, and metabolite, significantly improved the performance in discriminating malignant lung nodules from benign lung nodules compared to the performance of pro-sftpb and DAS, suggesting the potential of this innovative approach to develop an optimal blood-base biomarker panel with integrating multiple assay platforms. The impact on other disciplines The impact on technology transfer The impact on society beyond science and technology 5. Changes/Problems 6. Products 7. Participants & Other Collaborating Organizations Individuals in the project Ayumu Taguchi: No change. Ignacio Wistuba: No change. Samir Hanash: No change. Ziding Feng: No change. 7
8 Name: Project Role: Researcher Identifier (e.g. ORCID ID): Nearest person month worked: Contribution to Project: Funding Support: Gargy Parhy Research Assistant NA 4 Ms. Parhy will work on assay development and validation under supervision of Drs. Ayumu Taguchi and Ichidai Tanaka. The MDACC startup funds Name: Project Role: Researcher Identifier (e.g. ORCID ID): Nearest person month worked: Contribution Project: Funding Support: to Ichidai Tanaka Postdoctoral Fellow NA 3 Dr. Tanaka is highly experienced in assay development and analysis and will work on assay of biomarkers and marker validation under supervision of Dr. Ayumu Taguchi. The MDACC startup funds Change in the active other support of the PD/PI(s) or senior/key personnel 8. Special Reporting Requirements NA 9. Appendices NA 8
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AWARD NUMBER: W81XWH-13-1-0408 TITLE: Pathogenesis and Prediction of Future Rheumatoid Arthritis PRINCIPAL INVESTIGATOR: Kevin D. Deane, MD/PhD CONTRACTING ORGANIZATION: University of Colorado Denver,
Award Number: W81XWH TITLE: Characterizing an EMT Signature in Breast Cancer. PRINCIPAL INVESTIGATOR: Melanie C.
AD Award Number: W81XWH-08-1-0306 TITLE: Characterizing an EMT Signature in Breast Cancer PRINCIPAL INVESTIGATOR: Melanie C. Bocanegra CONTRACTING ORGANIZATION: Leland Stanford Junior University Stanford,
TITLE: TREATMENT OF ENDOCRINE-RESISTANT BREAST CANCER WITH A SMALL MOLECULE C-MYC INHIBITOR
AD Award Number: W81XWH-13-1-0159 TITLE: TREATMENT OF ENDOCRINE-RESISTANT BREAST CANCER WITH A SMALL MOLECULE C-MYC INHIBITOR PRINCIPAL INVESTIGATOR: Qin Feng CONTRACTING ORGANIZATION: Baylor College of
TITLE: Properties of Leukemia Stem Cells in a Novel Model of CML Progression to Lymphoid Blast Crisis
AD Award Number: W81XWH-05-1-0608 TITLE: Properties of Leukemia Stem Cells in a Novel Model of CML Progression to Lymphoid Blast Crisis PRINCIPAL INVESTIGATOR: Craig T. Jordan, Ph.D. CONTRACTING ORGANIZATION:
PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland
AWARD NUMBER: W81XWH-13-1-0463 TITLE: The Ketogenic Diet and Potassium Channel Function PRINCIPAL INVESTIGATOR: Dr. Geoffrey Murphy CONTRACTING ORGANIZATION: University of Michigan Ann Arbor, MI 48109
Approved for public release; distribution unlimited
Award Number: W81XWH-10-1-1021 TITLE: Post-traumatic Headache and Psychological Health: Mindfulness Training for Mild Traumatic Brain Injury PRINCIPAL INVESTIGATOR: Sutapa Ford, PhD CONTRACTING ORGANIZATION:
CONTRACTING ORGANIZATION: Fred Hutchinson Cancer Research Center Seattle, WA 98109
AWARD NUMBER: W81XWH-10-1-0711 TITLE: Transgenerational Radiation Epigenetics PRINCIPAL INVESTIGATOR: Christopher J. Kemp, Ph.D. CONTRACTING ORGANIZATION: Fred Hutchinson Cancer Research Center Seattle,
PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland
AWARD NUMBER: W81XWH-16-1-0737 TITLE: Developing a PTEN-ERG Signature to Improve Molecular Risk Stratification in Prostate Cancer PRINCIPAL INVESTIGATOR: Tamara Lotan CONTRACTING ORGANIZATION: Johns Hopkins
TITLE: Maximizing Energy After Traumatic Brain Injury: A Novel Intervention
AD Award Number: W81XWH-10-1-0920 TITLE: Maximizing Energy After Traumatic Brain Injury: A Novel Intervention PRINCIPAL INVESTIGATOR: Ketki D. Raina,PhD, OTR/L CONTRACTING ORGANIZATION: University of Pittsburgh
TITLE: Central Tolerance Blockade to Augment Checkpoint Immunotherapy in Melanoma
AWARD NUMBER: W81XWH-15-1-0411 TITLE: Central Tolerance Blockade to Augment Checkpoint Immunotherapy in Melanoma PRINCIPAL INVESTIGATOR: Maureen Su CONTRACTING ORGANIZATION: The University of North Carolina
Award Number: W81XWH
AD Award Number: W81XWH-08-2-0050 TITLE: PT073853: Mild TBI Following Exposure to Explosive Devices: Device Characteristics, Neuropsychological Functioning, and Symptoms of Post-Traumatic Stress Disorder
CONTRACTING ORGANIZATION: Vanderbilt University Medical Center Nashville, TN
AD Award Number: W81XWH-04-1-0867 TITLE: A Myc-Driven in Vivo Model of Human Prostate Cancer PRINCIPAL INVESTIGATOR: Simon W. Hayward, Ph.D. CONTRACTING ORGANIZATION: Vanderbilt University Medical Center
TITLE: Targeting the Immune System s Natural Response to Cell Death to Improve Therapeutic Response in Breast Cancers
AD Award Number: W81XWH-13-1-0158 TITLE: Targeting the Immune System s Natural Response to Cell Death to Improve Therapeutic Response in Breast Cancers PRINCIPAL INVESTIGATOR: Rebecca S. Cook CONTRACTING
TITLE: Investigation of the Akt/PKB Kinase in the Development of Hormone-Independent Prostate Cancer
AD Award Number: TITLE: Investigation of the Akt/PKB Kinase in the Development of Hormone-Independent Prostate Cancer PRINCIPAL INVESTIGATOR: Linda A. degraffenried, Ph.D. CONTRACTING ORGANIZATION: The
PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland
AWARD NUMBER: W81XWH-13-1-0203 TITLE: Targeting almitoyl cyltransferases in NRAS- elanoma PRINCIPAL INVESTIGATOR: Xu Wu, Ph.D. CONTRACTING ORGANIZATION: Massachusetts General Hospital, Boston, MA 02114
TITLE: Long Term Outcomes of BRCA1/BRCA2 Mutation Testing. CONTRACTING ORGANIZATION: Georgetown University Washington, DC
AD AWARD NUMBER: DAMD17-03-1-0553 TITLE: Long Term Outcomes of BRCA1/BRCA2 Mutation Testing PRINCIPAL INVESTIGATOR: Marc D. Schwartz, Ph.D. CONTRACTING ORGANIZATION: Georgetown University Washington, DC
TITLE: Short-Term Exercise and Prostate Cancer Prevention in African American Men. CONTRACTING ORGANIZATION: Howard University Washington DC 20059
AD Award Number: W81XWH-05-1-0366 TITLE: Short-Term Exercise and Prostate Cancer Prevention in African American Men PRINCIPAL INVESTIGATOR: Teletia R. Taylor, Ph.D. CONTRACTING ORGANIZATION: Howard University
TITLE: Mission Connect Mild TBI Translational Research Consortium. U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland
Award Number: W81XWH-08-2-0138 TITLE: Mission Connect Mild TBI Translational Research Consortium PRINCIPAL INVESTIGATOR: Brent Masel. M.D. CONTRACTING ORGANIZATION: Transitional Learning Center at Galveston
TITLE: Functional Genetics for Predisposition to Development of Type 2 Diabetes in Obese Individuals. PRINCIPAL INVESTIGATOR: Assia Shisheva
AWARD NUMBER: W81XWH-17-1-0060 TITLE: Functional Genetics for Predisposition to Development of Type 2 Diabetes in Obese Individuals PRINCIPAL INVESTIGATOR: Assia Shisheva CONTRACTING ORGANIZATION: Wayne
TITLE: Psychosocial Stress and Ovarian Cancer Risk: Metabolomics and Perceived Stress
AWARD NUMBER: W81XWH-13-1-0493 TITLE: Psychosocial Stress and Ovarian Cancer Risk: Metabolomics and Perceived Stress PRINCIPAL INVESTIGATOR: Elizabeth M. Poole CONTRACTING ORGANIZATION: Brigham and Women's
TITLE: Genetic and epigenetic biomarkers for recurrent prostate cancer after radiotherapy
AD Award Number: W81XWH-12-1-0113 TITLE: Genetic and epigenetic biomarkers for recurrent prostate cancer after radiotherapy PRINCIPAL INVESTIGATOR: Jong Park CONTRACTING ORGANIZATION: H. Lee Moffitt Cancer
TITLE: Post-Traumatic Headache and Psychological Health: Mindfulness Training for Mild Traumatic Brain Injury
AD Award Number: W81XWH-10-1-1021 TITLE: Post-Traumatic Headache and Psychological Health: Mindfulness Training for Mild Traumatic Brain Injury PRINCIPAL INVESTIGATOR: Sutapa Ford, Ph.D. CONTRACTING ORGANIZATION:
PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland
AWARD NUMBER: W81XWH-13-1-0408 TITLE: Pathogenesis and Prediction of Future Rheumatoid Arthritis PRINCIPAL INVESTIGATOR: Kevin D. Deane, MD/PhD CONTRACTING ORGANIZATION: Regents of the University of Colorado
TITLE: Interchromosomal Associations that Alter NF1 Gene Expression Can Modify Clinical Manifestations of Neurofibromatosis 1. Palo Alto, CA 94304
AD AWARD NUMBER: W81XWH-06-1-0695 TITLE: Interchromosomal Associations that Alter NF1 Gene Expression Can Modify Clinical Manifestations of Neurofibromatosis 1 PRINCIPAL INVESTIGATOR: Andrew R. Hoffman,
Award Number: W81XWH TITLE: Dietary Fish Oil in Reducing Bone Metastasis of Breast Cancer
AD Award Number: W81XWH-04-1-0693 TITLE: Dietary Fish Oil in Reducing Bone Metastasis of Breast Cancer PRINCIPAL INVESTIGATOR: Nandini Ghosh-Choudhury, Ph.D. CONTRACTING ORGANIZATION: University of Texas
Award Number: W81XWH TITLE: A Novel Membrane-Permeable, Breast-Targeting, Pro-Apoptotic Peptide for Treatment of Breast Cancer
AD Award Number: W81XWH-04-1-0705 TITLE: A Novel Membrane-Permeable, Breast-Targeting, Pro-Apoptotic Peptide for Treatment of Breast Cancer PRINCIPAL INVESTIGATOR: Bin Guo, Ph.D. CONTRACTING ORGANIZATION:
TITLE: A Tissue Engineering Approach to Study the Progression of Breast Tumor Metastasis in Bone
AD AWARD NUMBER: W81XWH-04-1-0749 TITLE: A Tissue Engineering Approach to Study the Progression of Breast Tumor Metastasis in Bone PRINCIPAL INVESTIGATOR: Mingxin Che, M.D., Ph.D. Daotai Nie, Ph.D. CONTRACTING
TITLE: Computerized Tailored Interventions for Behavioral Sequelae of Post-Traumatic Stress Disorder in Veterans
AD (Leave blank) Award Number: W81XWH-09-2-0106 TITLE: Computerized Tailored Interventions for Behavioral Sequelae of Post-Traumatic Stress Disorder in Veterans PRINCIPAL INVESTIGATOR: Sarah D. Miyahira,
The Chancellor, Masters and Scholars of the University of Cambridge, Clara East, The Old Schools, Cambridge CB2 1TN
AWARD NUMBER: W81XWH-14-1-0110 TITLE: A Molecular Framework for Understanding DCIS PRINCIPAL INVESTIGATOR: Gregory Hannon CONTRACTING ORGANIZATION: The Chancellor, Masters and Scholars of the University
PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland
AD AWARD NUMBER: DAMD17-02-C-0134 TITLE: Integrative Medicine Distance-Learning Program PRINCIPAL INVESTIGATOR: Howard Silverman, M.D. CONTRACTING ORGANIZATION: University of Arizona Tucson, Arizona 85722
CONTRACTING ORGANIZATION: The Chancellor, Masters and Scholars of the University of Cambridge, Clara East, The Old Schools, Cambridge CB2 1TN
AWARD NUMBER: W81XWH-14-1-0110 TITLE: A Molecular Framework for Understanding DCIS PRINCIPAL INVESTIGATOR: Gregory Hannon CONTRACTING ORGANIZATION: The Chancellor, Masters and Scholars of the University
CONTRACTING ORGANIZATION: Rutgers, the State University of New Jersey New Brunswick, NJ 08901
AWARD NUMBER: W81XWH-16-1-0415 TITLE: Cell Type-Specific Contributions to the TSC Neuropathology PRINCIPAL INVESTIGATOR: Gabriella D Arcangelo CONTRACTING ORGANIZATION: Rutgers, the State University of
Award Number: W81XWH TITLE: "Longitudinal Study of a Novel Performance-based Measure of Daily Function."
Award Number: W81XWH-12-1-0084 TITLE: "Longitudinal Study of a Novel Performance-based Measure of Daily Function." PRINCIPAL INVESTIGATOR: Terry Goldberg, PhD CONTRACTING ORGANIZATION: The Feinstein Institute
CONTRACTING ORGANIZATION: University of Minnesota St Paul, MN 55108
AD Award Number: W81XWH-06-1-0778 TITLE: Dietary Fat, Eicosanoids and Breast Cancer Risk PRINCIPAL INVESTIGATOR: Lindsay Orr CONTRACTING ORGANIZATION: University of Minnesota St Paul, MN 55108 REPORT DATE:
TITLE: Role of ADAM15 in Tumor/Endothelial Interactions Prostate Cancer Regression
AD Award Number: W81XWH-07-1-0030 TITLE: Role of ADAM15 in Tumor/Endothelial Interactions Prostate Cancer Regression PRINCIPAL INVESTIGATOR: Mark L. Day CONTRACTING ORGANIZATION: University of Michigan
TITLE: Adipose Estrogen and Increased Breast Cancer Risk in Obesity: Regulation by Leptin and Insulin
AD Award Number: W81XWH-05-1-0497 TITLE: Adipose Estrogen and Increased Breast Cancer Risk in Obesity: Regulation by Leptin and Insulin PRINCIPAL INVESTIGATOR: Fahumiya Samad CONTRACTING ORGANIZATION:
TITLE: Treatment of Dengue Virus Infection with Repurposed Pharmaceuticals that Inhibit Autophagy
AWARD NUMBER: W81XWH-16-1-0074 TITLE: Treatment of Dengue Virus Infection with Repurposed Pharmaceuticals that Inhibit Autophagy PRINCIPAL INVESTIGATOR: Karla Kirkegaard, Ph.D. CONTRACTING ORGANIZATION:
TITLE: The Role of HOX Proteins in Androgen-Independent Prostate Cancer
AD Award Number: W81XWH-6-1-64 TITLE: The Role of HOX Proteins in Androgen-Independent Prostate Cancer PRINCIPAL INVESTIGATOR: Sunshine Daddario, B.A. CONTRACTING ORGANIZATION: University of Colorado Health
TITLE: Inhibitors of Histone Deacetylases for Radiosensitization of Prostate Cancer
AD Award Number: W81XWH-04-1-0170 TITLE: Inhibitors of Histone Deacetylases for Radiosensitization of Prostate Cancer PRINCIPAL INVESTIGATOR: Mira O. Jung, Ph.D. CONTRACTING ORGANIZATION: Georgetown University
CONTRACTING ORGANIZATION: Spaulding Rehabilitation Hospital, Boston, MA 02129
AD Award Number: W81XWH-10-1-1043 TITLE: FES-Rowing versus Zoledronic Acid to Improve Bone Health in SCI PRINCIPAL INVESTIGATOR: Leslie R. Morse, DO CONTRACTING ORGANIZATION: Spaulding Rehabilitation Hospital,
CONTRACTING ORGANIZATION: Mount Sinai School of Medicine New York, New York
AD AWARD NUMBER: W81XWH-05-1-0475 TITLE: Restoration of Epithelial Polarity in Metastatic Tumors PRINCIPAL INVESTIGATOR: Sergei Sokol, Ph.D. CONTRACTING ORGANIZATION: Mount Sinai School of Medicine New
TITLE: Overcoming Resistance to Inhibitors of the Akt Protein Kinase by Modulation of the Pim Kinase Pathway
AWARD NUMBER: W81XWH-12-1-0560 TITLE: Overcoming Resistance to Inhibitors of the Akt Protein Kinase by Modulation of the Pim Kinase Pathway PRINCIPAL INVESTIGATOR: Andrew S. Kraft, MD CONTRACTING ORGANIZATION:
PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, MD
AD Award Number: W81XWH-11-1-0126 TITLE: Chemical strategy to translate genetic/epigenetic mechanisms to breast cancer therapeutics PRINCIPAL INVESTIGATOR: Xiang-Dong Fu, PhD CONTRACTING ORGANIZATION:
CONTRACTING ORGANIZATION: Cleveland Clinic Foundation Cleveland, OH 44195
AD (Leave blank) Award Number: W81XWH-08-2-0211 TITLE: Deep Brain Stimulation Deep Brain Stimulation of Treatment of Traumatic Brain Injury PRINCIPAL INVESTIGATOR: Imad Najm, MD CONTRACTING ORGANIZATION: