Single donator specimens as advantage in external quality control assessments of infectious diseases
|
|
- Lesley York
- 6 years ago
- Views:
Transcription
1 Single donator specimens as advantage in external quality control assessments of infectious diseases MD, PhD Maija Lappalainen and MD Jukka Suni HUSLAB, Department of Virology Labquality Days
2 Definitions Quality control refers to the measures that must be included during each assay run to verify that the test is working properly. Quality assurance is defined as the overall program that ensures that the final results reported by the laboratory are correct. Therefore, quality assurance is concerned with much more: that the right test is carried out on the right specimen, and that the right result and right interpretation is delivered to the right person at the right time
3 Definitions Quality assessment (also known as proficiency testing) is a means to determine the quality of the results generated by the laboratory. Quality assessment is a challenge to the effectiveness of the QA and QC programs. Quality Assessment may be external or internal, examples of external programs include Labquality, NEQAS, and QCMD.
4 Requirements for EQA what do the standards tell us? SFSEN ISO/IEC 17025:2005 General requirements for the competence of testing and calibration laboratories: The laboratory shall have quality control procedures for monitoring the validity of tests and calibrations undertaken. The resulting data shall be recorded in such a way that trends are detectable and, where practicable, statistical techniques shall be applied to the reviewing of the results.
5 Requirements for EQA what do the standards tell us? SFSEN ISO Medical laboratories. Particular requirements for quality and competence: External quality assessment programmes should, as far as possible, provide clinically relevant challenges that mimic patient samples and have the effect of checking the entire examination process, including pre and postexamination procedures.
6 Variables that affect the quality of results The educational background and training of the laboratory personnel The condition of the specimens The controls used in the test runs Reagents Equipment The interpretation of the results The reporting of results
7 Results and reporting in the diagnosis of infectious diseases Test result interpretation (background, other tests, patient history) Result reported for the clinician
8 Puzzle a problem designed to test knowledge or patience (The Oxford Handy Dictionary, modified)
9 External Quality assessment programs; specimens EQA specimens for infectious diseases (serology) are either: (1) Single donator plasma/serum samples or (2) Pooled plasma/serum samples The benefits of using a single donator specimens are: (1) Mimic patient samples (2) Not only samples, but samples with a history (3) A relevant test result combination (4) Less problems with unspecific test results
10 Serodiagnosis of Hepatitis B virus infection HBsAg : acute or chronic HBV infection HBcAb ja HBsAb: previous HBV infection HBsAb: vaccinated
11 Example 1. Hepatitis B HBsAg: HBcAb: HBeAg: HBeAb: HBcAbM: HBsAb: HBsAg: HBcAb: HBeAg:!!! HBeAb: HBcAbM: HBsAb:
12 Epstein Barr Virus, EBV and infectious mononucleosis, IM
13 EBV associated diseases 95% of people are seropositive Asymptomatic/minor symptoms Often small children Infectious mononucleosis (IM) Children, adolescents Symptomatic disease Adults (hepatitis, jaundice) EBV associated diseases Burkitt lymphoma Nasopharyngeal carcinoma Posttransplant lymphoproliferative disease (PTLD)
14 Antibody responses in EBVinfection Incubation (12 mos) symptoms (12 wks) recovery 6 mos EBNA and Avidity VCA IgG VCA IgM Heterophile abs.
15 EBVinfection Interpretation of serological findings Rapid Ly VCA VCA EBNA1 Interpretation test atypical IgG IgM IgG / / Acute infection Recovered No infection / / Indeterminate Indeterminate Indeterminate Not possible / Not possible
16 EBVserology Pretest
17 HIV infection and serology
18 Diagnostic tests of HIVinfection Detection of antibodies in IgGclass Detection of total antibodies Detection of total antibodies and HIV p24 antigen in the same assay, COMBI Immunoblot (Western blot) of IgGclass of antibodies HIV p24antigen assay HIV1 RNA PCR, qualitative HIV1 RNA PCR, quantitative
19 HIVserology report targets HIVantibody negative HIVantibody positive Old infection Recent infection Early HAART therapy
20 A simple scheme for HIV serology algorithm HIVAgAb Combi QUALITATIVE Positive Negative HIVAb HIV p24antigen Report Negative QUANTITATIVE Positive Immunoblot Report with HIV p24antigen
21 HIV immunoblot (INNOLIA ) 1:1 1:10 1:50 POS NEG AxSYM AxSYM AxSYM AxSYM AxSYM
Microbiology EQA Product Portfolio
Labquality EQAS Microbiology EQA Product Portfolio Clinically relevant external quality assessment program for microbiology Bacterial serology Bacteriology Mycology Parasitology Preanalytics Virology Labquality
More informationThe use of QCMD proficiency testing panels in clinical virology.
The use of QCMD proficiency testing panels in clinical virology. Prof.dr. Bert Niesters Department of Medical Microbiology Division of Clinical Virology UMC Groningen Disease Disease Management Viral Load
More informationViral Hepatitis Diagnosis and Management
Viral Hepatitis Diagnosis and Management CLINICAL BACKGROUND Viral hepatitis is a relatively common disease (25 per 100,000 individuals in the United States) caused by a diverse group of hepatotropic agents
More informationLab Underwriting Puzzler. Presented by: Bill Rooney, M.D.
Lab Underwriting Puzzler Presented by: Bill Rooney, M.D. Obtaining Best Results from this presentation For best results please do the following: Select Slide Show from the menu option on top Select From
More informationThe Alphabet Soup of Viral Hepatitis Testing
The Alphabet Soup of Viral Hepatitis Testing August 18, 2011 Patricia Slev, PhD, DABCC Medical Director, Serologic Hepatitis and Retrovirus Laboratory, ARUP Laboratories Assistant Professor of Pathology,
More informationالحترمونا من خري الدعاء
الحترمونا من خري الدعاء Instructions for candidates The examination consists of 30 multiple choice questions, each divided into 5 different parts. Each part contains a statement which could be true or
More informationEBV and Infectious Mononucleosis. Infectious Disease Definitions. Infectious Diseases
Infectious Disease Definitions Infection when a microorganism invades a host and multiplies enough to disrupt normal function by causing signs and symptoms Pathogencity ability of an organism to cause
More informationClinical Aspect and Application of Laboratory Test in Herpes Virus Infection. Masoud Mardani M.D,FIDSA
Clinical Aspect and Application of Laboratory Test in Herpes Virus Infection Masoud Mardani M.D,FIDSA Shahidhid Bh BeheshtiMdi Medical lui Universityit Cytomegalovirus (CMV), Epstein Barr Virus(EBV), Herpes
More informationStructure and duties of Blood service
NATIONAL CENTER FOR TRANSFUSION MEDICINE Prevalence of infectious diseases among Mongolian blood donors Namjil Erdenebayar General director of The National Center for Transfusion Medicine, Mongolia NCTM,
More informationUNDER REVIEW. UK Standards for Microbiology Investigations. Epstein-Barr Virus Serology
UK Standards for Microbiology Investigations Issued by the Standards Unit, Microbiology Services, PHE Virology V 26 Issue no: 4.1 Issue date: 15.04.14 Page: 1 of 12 Crown copyright 2014 Acknowledgments
More informationUnited Kingdom National External Quality Assessment Service for Microbiology [Established 1971]
United Kingdom National External Quality Assessment Service for Microbiology [Established 97] UK NEQAS covers Andrology Chemistry Genetics Haematology Histopathology Immunology Leucocyte Immunophenotyping
More informationSee external label 2 C-8 C Σ=96 tests Cat # EBV-VCA IgA. Cat # EBV -VCA IgA ELISA. ELISA: Enzyme Linked Immunosorbent Assay
DIAGNOSTIC AUTOMATION, INC. 23961 Craftsman Road, Suite D/E/F, Calabasas, CA 91302 Tel: (818) 591-3030 Fax: (818) 591-8383 onestep@rapidtest.com technicalsupport@rapidtest.com www.rapidtest.com See external
More informationTest Name Results Units Bio. Ref. Interval
LL - LL-ROHINI (NATIONAL REFERENCE 135091606 Age 24 Years Gender Male 30/8/2017 92800AM 30/8/2017 94631AM 31/8/2017 90306AM Ref By Final HEATITIS A & B VIRUS EVALUATION HEATITIS A ANTIBODY (ANTI HAV),
More informationHEPATITIS B NON-IMMEDIATE NOTIFICATION EPIDEMIOLOGY PROGRAM
HEPATITIS B NON-IMMEDIATE NOTIFICATION EPIDEMIOLOGY PROGRAM Event Name: Event Time Period: ACUTE Clinical Presentation (CDC 2012): CDC Event (2012): HEPB Lifelong immunity An acute illness with a discrete
More informationEBV Infection. > Cellular Immune Response Profiling. > Humoral Immune Response Profiling EBV. ImmunoTools
EBV ImmunoTools Peptide Tools to Study EBV EBV Infection > Cellular Immune Response Profiling Antigen spanning EBV PepMix Peptide Pools PepMix Collection EBV > Humoral Immune Response Profiling EBV RepliTope
More informationFINAL REPORT HBV Serology External Quality Assessment Scheme
FINAL REPORT HBV Serology External Quality Assessment Scheme Programme codes: HBVC4310, HBVC435 Panel ID: 2008/Oct/28 HBV Serology EQAS Panel ID 2008/Oct/28 Page 1 of 11 The NRL is a: NATA-accredited proficiency
More informationInstruction Manual. EBV VCA IgG ELISA
Instruction Manual EBV VCA IgG ELISA Enzyme immunoassay based on microtiter plate for the detection and quantitative determination of human IgG antibodies against EBV VCA in serum and plasma Cat. No.:
More informationArm yourself against Hep B! Vaccinate
Arm yourself against Hep B! Vaccinate Arm yourself against Hep B! Vaccinate Written by Injecting Drug Users for Injecting Drug Users Why it s important for injecting drug users to know about and understand
More informationTEST REQUEST INFORMATION- VIROLOGY
Chlamydia/ Gonorrhea Nucleic Acid Amplification VC75 Qualitative Nucleic Acid Amplification SPECIMEN: Genital swab or first catch urine CONTAINER:GEN-PROBE APTIMA 2 Combo swab transport tube or urine transport
More informationInfectious Mononucleosis The Virus Pathophysiology: Age: History: Fever. Lymphadenopathy
Infectious Mononucleosis The Virus A member of the Herpesvirus family Infects human B lymphocytes Herpes viruses contain double-stranded DNA, and they have an icosahedral capsid and a glycoprotein-containing
More informationEBV-EA IgG. Cat # 1415Z. EBV -EA IgG ELISA. ELISA: Enzyme Linked Immunosorbent Assay. ELISA - Indirect; Antigen Coated Plate
DIAGNOSTIC AUTOMATION, INC. 23961 Craftsman Road, Suite D/E/F, Calabasas, CA 91302 Tel: (818) 591-3030 Fax: (818) 591-8383 onestep@rapidtest.com technicalsupport@rapidtest.com www.rapidtest.com See external
More informationMultiple Choice Questions - Paper 1
Multiple Choice Questions - Paper 1 Instructions for candidates The examination consists of 30 multiple choice questions, each divided into 5 different parts. Each part contains a statement which could
More informationSchedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK Royal Liverpool & Broadgreen University Hospitals NHS Trust Department of Virology Liverpool Clinical Laboratories Royal Liverpool and Broadgreen
More informationWHO Prequalification of In Vitro Diagnostics Programme
WHO Prequalification of In Vitro Diagnostics Programme International HIV/Viral Hepatitis Co-Infection Satellite Meeting 19 July 2014, Melbourne Anita Sands Prequalification Diagnostics Team Department
More informationDEPARTMENT OF GENITO-URINARY MEDICINE HEPATITIS B
DEPARTMENT OF GENITO-URINARY MEDICINE MAIN TRANSMISSION ROUTES HEPATITIS B Sexual transmission Occurs in unvaccinated/non immune men who have sex with men and correlates with multiple partners, unprotected
More informationUK Standards for Microbiology Investigations
UK Standards for Microbiology Investigations Epstein-Barr Virus Serology Issued by the Standards Unit, Microbiology Services, PHE Virology V 26 Issue no: 5 Issue date: 03.07.15 Page: 1 of 13 Crown copyright
More informationHepatitis A virus (HAV)
Volume 3, Issue 1 (Jan 2010) Editor s note Happy New Year and welcome to the first issue of QA Highlights of year 2010! In this issue, we are happy to bring to you Hepatitis Infection and Clinical Detection
More informationTest Name Results Units Bio. Ref. Interval
LL - LL-ROHINI (NATIONAL REFERENCE 135091650 Age 49 Years Gender Male 29/8/2017 120000AM 29/8/2017 100248AM 29/8/2017 105306AM Ref By Final HEATITIS, VIRAL, COMREHENSIVE ANEL HEATITIS A ANTIBODY (ANTI
More informationCDC website:
Hepatitis B virus CDC website: http://www.cdc.gov/ncidod/diseases/hepatitis/slideset/hep_b/slide_1.htm Relevance Key Features es of Hepatitis t B Virus 250 million people infected worldwide. In areas of
More informationJune EQA schemes closed. Information on sample properties. Prof. Dr. Heinz Zeichhardt. Dr. Martin Kammel
June 2018 EQA schemes closed Information on sample properties Prof. Dr. Heinz Zeichhardt Dr. Martin Kammel Issued by: INSTAND Gesellschaft zur Förderung der Qualitätssicherung in medizinischen Laborarien
More informationIMMUNODOT MONO-M TEST
IMMUNODOT MONO-M TEST For In Vitro Diagnostic Use INTENDED USE The Mono-M Test is a qualitative enzyme immunoassay (EIA) that detects IgM antibodies to Paul-Bunnell heterophil, Epstein- Barr virus capsid
More informationThe Dubbo Infection Outcomes Study
The Dubbo Infection Outcomes Study Determinants of protracted illness after acute infection Dubbo Infection Outcomes Study Three parallel cohorts Epstein-Barr virus: - infectious mononucleosis - established
More informationIMMUNODOT MONO-G TEST
IMMUNODOT MONO-G TEST For In Vitro Diagnostic Use INTENDED USE The Mono-G Test is a qualitative enzyme immunoassay (EIA) that detects IgG antibodies to Epstein-Barr virus capsid antigen (EBV-VCA), Epstein-Barr
More informationIl ruolo delle VEQ per la sicurezza trasfusionale
Il ruolo delle VEQ per la sicurezza trasfusionale The role of EQA for transfusion safety Giulio Pisani CNCF Ist. Sup. Sanità Global Blood Product Safety, Roma 10 aprile 2019 Blood transfusion is an essential
More informationRepetitorium of selected human viruses HIV
Repetitorium of selected human viruses HIV Chair and Department of Medical Microbiology Poznan University of Medical Sciences Chairman: prof. dr hab. Andrzej Szkaradkiewicz Wieniawskiego Street 3, 61-712
More informationDiagnostic Methods of HBV and HDV infections
Diagnostic Methods of HBV and HDV infections Zohreh Sharifi,ph.D Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine Hepatitis B-laboratory diagnosis Detection
More informationMedia centre. WHO Hepatitis B. Key facts. 1 of :12 AM.
1 of 5 2013-08-02 7:12 AM Media centre Hepatitis B Share Print Fact sheet N 204 Updated July 2013 Key facts Hepatitis B is a viral infection that attacks the liver and can cause both acute and chronic
More informationTHE ROLE OF anti-ebna1 IgG DETERMINATION IN EBV DIAGNOSTICS
Journal of IMAB ISSN: 1312-773X https://www.journal-imab-bg.org https://doi.org/10.5272/jimab.2018243.2181 Journal of IMAB - Annual Proceeding (Scientific Papers). 2018 Jul-Sep;24(3) Original article THE
More informationEnd Stage Liver Disease & Disease Specific Indications for Liver Transplant. Susan Kang, RN, MSN, ANP-BC
End Stage Liver Disease & Disease Specific Indications for Liver Transplant Susan Kang, RN, MSN, ANP-BC Introduction (https://www.srtr.org) What does the liver do? STORAGE METABOLIC DETOXIFICATION SYNTHETIC
More informationEnd Stage Liver Disease & Disease Specific Indications for Liver Transplant Susan Kang, RN, MSN, ANP BC
End Stage Liver Disease & Disease Specific Indications for Liver Transplant Susan Kang, RN, MSN, ANP BC Introduction (https://www.srtr.org) 1 What does the liver do? STORAGE METABOLIC DETOXIFICATION SYNTHETIC
More informationHIV Serology Quality Assessment Program Summary for Panel HIVSER 2017Apr19
National Laboratory for HIV Reference Services National HIV and Retrovirology Laboratories National Microbiology Laboratory Public Health Agency of Canada HIV Serology Quality Assessment Program Summary
More informationTalk overview. Case 1. Case Examples 21/07/2017. Epstein Barr Virus (EBV) quantification in health and disease Bit of background Recent case examples
Belfast Pathology 2017 EBV Quantification in health and disease Talk overview Epstein Barr Virus (EBV) quantification in health and disease Bit of background Recent case examples Susan Feeney PhD FRCPath
More informationEBV Early Antigen IgM ELISA
Instruction Manual EBV Early Antigen IgM ELISA Catalog number: 40-375-380027 Enzyme immunoassay based on microtiter plate for the detection and quantitative determination of human IgM antibodies against
More informationEBV-VCA IgA Cat #
DIAGNOSTIC AUTOMATION, INC. 23961 Craftsman Road, Suite E/F, Calabasas, CA 91302 Tel: (818) 591-3030 Fax: (818) 591-8383 onestep@rapidtest.com technicalsupport@rapidtest.com www.rapidtest.com See external
More informationLaboratory diagnostics of blood-borne infections related to blood transfusions and transplantations
26 th Symposium Croatian Society of Medical Biochemistry and Laboratory Medicine Laboratory diagnostics of blood-borne infections related to blood transfusions and transplantations Croatian Institute of
More informationEBV Protocol
EBV Protocol 8.26.14 Data From UNOS Summary Stats 1988-2014 CASU + 2009-2014 CAPC Organ Total PTLD Percent PTLD Percent PTLD in Literature Heart 294 21 7 3-9 Heart-Lung 34 3 9 16 Intestine 42 7 17 10-45
More informationHepadnaviridae family (DNA) Numerous antigenic components Humans are only known host May retain infectivity for more than 7 days at room temperature
Hepatitis B Epidemic jaundice described by Hippocrates in 5th century BC Jaundice reported among recipients of human serum and yellow fever vaccines in 1930s and 1940s Australia antigen described in 1965
More informationEpstein-Barr Virus 1
Epstein-Barr Virus 1 Herpesviruses dsdna, linear, enveloped, 180-200 nm Large genome, codes for 75 viral proteins 50-70% similarity Cross reactivity between HSV and VZV HSV-2 virus particle. Note that
More informationDS-EIA-ANTI-HIV-UNIF (Ab) I DS-EIA-ANTI-HIV-UNIF (Ab) I DS-EIA-ANTI-HIV-UNIF (Ab) I
* Sensitivity HIV DS-EIA-ANTI-HIV-UNIF (Ab) I-153 96 115 24 DS-EIA-ANTI-HIV-UNIF (Ab) I-150 192 115 24 DS-EIA-ANTI-HIV-UNIF (Ab) I-155 480 115 24 DS-EIA-HIV-AG-SCREEN I-1452 96 115 12 0.025 IU/ml DS-EIA-HIV-AGAB-SCREEN
More informationDetection of Antibodies to Epstein-Barr Virus Capsid Antigen
JOURNAL OF CLINICAL MICROBIOLOGY, Jan. 1982, p. 69-73 95-1137/82/169-5$2./ Vol. 15, No.1 Detection of Antibodies to Epstein-Barr Virus Capsid Antigen by Immune Adherence Hemagglutination EVELYNE T. LENNETTE,t
More informationComparison of Three Latex Agglutination Kits and a Commercial EIA for the Detection of Cryptococcal Antigen
Scientific review Scientific review Comparison of Three Latex Agglutination Kits and a Commercial EIA for the Detection of Cryptococcal Antigen J.E. Bestrom, D.J. Jespersen, and N.L. Wengenack Mayo Clinic,
More informationReQuest EBV EA-D IgG
ReQuest EA-D IgG Intended Use 01-490 96-Test Set The ReQuest EA-D IgG test is for the qualitative detection of human IgG antibodies to Epstein-Barr virus early antigen diffuse (EA-D) in human serum by
More informationDonor Screening in The Region. Vincini GA NRL, Melbourne, Australia
Donor Screening in The Region Vincini GA NRL, Melbourne, Australia NRL Established in 1985 Not-for-profit organisation that exists to support laboratories that perform testing for the diagnosis and management
More informationEpstein Barr Virus VCA IgG ELISA Kit
Epstein Barr Virus VCA IgG ELISA Kit Catalog Number KA1443 192 assays Version: 02 Intended for research use only www.abnova.com Table of Contents Introduction... 3 Intended Use... 3 Principle of the Assay...
More informationControls & Calibrators. Disease Quality Controls
Controls & Calibrators Infectious Disease Quality Controls Infectious Disease Quality Controls A broad selection of controls designed to monitor assay precision of hepatitis, retrovirus, sexually transmitted
More informationBioPlex 2200 Infectious Disease Panels
BioPlex 2200 System BioPlex 2200 Infectious Disease Panels An Expanding Multiplexed Assay Menu Lyme HIV Ag-Ab MMV IgM Syphilis Total & RPR MMRV EBV HSV-1 & HSV-2 EBV IgM ToRC IgM ToRC Leading the way with
More informationReQuest EB VCA IgM L
01-480 96-Test Set For in Vitro Diagnostic Use Only Intended Use: For the qualitative detection of human IgM antibodies to Epstein-Barr (EB) viral capsid antigen (VCA) in human serum by enzyme immunoassay,
More informationEBV EA-D IgG. Intended Use. Summary and Explanation of Test. Principle of the Test. Materials Provided. Materials Required But Not Provided
EA-D IgG Intended Use 01-490 96-Test Set The SeraQuest EA-D IgG test is for the qualitative detection of human IgG antibodies to Epstein-Barr virus early antigen diffuse (EA-D) in human serum by enzyme
More informationChronic Infectious Mononucleosis/EBV Management
Chronic Infectious Mononucleosis/EBV Management Hypothesis Continuous or intermittent Epstein-Barr virus (EBV) replication after primary EBV infection causes tissue damage resulting in a myriad of symptoms.
More informationTel: Tel: Web: CODE DESCRIPTION UNITS
New Instruments MICROPLATE ANALYZERS DESCRIPTION UNITS MDIMOD2 Modulus2 2-4 Microplate Analyzer 1 Refurbished Instruments MICROPLATE ANALYZERS DESCRIPTION UNITS MDINXGMI Refurbished Nexgen 4-Microplate
More informationCase Report Traumatic Haemorrhagic Cervical Lymphadenopathy with Underlying Infectious Mononucleosis
Hindawi Case Reports in Radiology Volume 2017, Article ID 3097414, 4 pages https://doi.org/10.1155/2017/3097414 Case Report Traumatic Haemorrhagic Cervical Lymphadenopathy with Underlying Infectious Mononucleosis
More informationTest Name Results Units Bio. Ref. Interval
LL - LL-ROHINI (NATIONAL REFERENCE 135091608 Age 26 Years Gender Female 30/8/2017 92900AM 30/8/2017 94717AM 31/8/2017 90216AM Ref By Final HEATITIS ACUTE VIRUS CONFIRMATION HEATITIS A ANTIBODY (ANTI HAV),
More informationFINAL REPORT HBV Serology External Quality Assessment Scheme
FINAL REPORT HBV Serology External Quality Assessment Scheme Programme codes: HBVC4310, HBVC435 Panel ID: 2008/Mar/11 HBV Serology EQAS Panel ID 2008/Mar/11 Page 1 of 9 The NRL is a: NATA-accredited proficiency
More informationHIV Serology Quality Assessment Program Summary for Panel HIVS Oct22
National Laboratory for HIV Reference Services National HIV and Retrovirology Laboratories National Microbiology Laboratory Public Health Agency of Canada HIV Serology Quality Assessment Program Summary
More informationTechnology makes many things possible, OBG. Tips on choosing the right tests and getting valid results. Signs of a hepatitis B carrier Page 49
OBG MANAGEMENT David A. Baker, MD Professor of Obstetrics, Gynecology, and Reproductive Medicine Director, Division of Infectious Diseases Health Sciences Center Stony Brook University Stony Brook, NY
More informationH. PYLORI AB, IGG HPYL
H. PYLORI AB, IGG HPYL Specimen Required: 3 ml blood, Serum gel tube Analytical Time: 1 day CPT Code: 86677 HAPTOGLOBIN HAP Specimen Required: 1.5 ml blood, gel tube Reference Range: 30-200 mg/dl CPT Code:
More informationImpact of Testing Strategies to Reduce Transmission Risk for HBV. Ravi Reddy, M Vermeulen South African National Blood Service (SANBS) 29 July 2013
Impact of Testing Strategies to Reduce Transmission Risk for HBV Ravi Reddy, M Vermeulen South African National Blood Service (SANBS) 29 July 2013 Overview of SANBS SANBS is a private not for profit company
More informationMemo No: Date: 25-Nov NEW Serology and Virology Testing
Memo No: 2014-61 Date: 25-Nov-2014 www.hicl.on.ca Re: NEW Serology and Virology Testing In Common Laboratories has been working hard to expand our test menu. We are pleased to announce the availability
More informationPROPOSAL FOR THE DEVELOPMENT OF AN INTERNATIONAL REFERENCE PREPARATION FOR HEPATITIS D VIRUS RNA
PROPOSAL FOR THE DEVELOPMENT OF AN INTERNATIONAL REFERENCE PREPARATION FOR HEPATITIS D VIRUS RNA SoGAT Clinical Diagnostics II 30 September / 1 October 2009, Istanbul Michael Chudy Julia Kreß C. Micha
More informationNEGATIVE POSITIVE. Rev , 06/11. 5 min. Mono Test. For fi ngertip. blood: 1 DROP 1 DROP For serum, whole blood. plasma or. samples.
Mono Test 1 2 1 DROP 1 DROP For serum, plasma or whole blood samples in tubes: For fi ngertip blood: 3 4 5 min POSITIVE NEGATIVE Rev. 3078-0, 06/11 Mono Test CLIA Complexity: Waived for Whole Blood Non-Waived
More informationScreening donors and donations for transfusion transmissible infectious agents. Alan Kitchen
Screening donors and donations for transfusion transmissible infectious agents Alan Kitchen Aim Not to teach you microbiology To provide and awareness of the big picture To provide an understanding of
More informationEpstein-Barr virus and immunity
Epstein-Barr virus and immunity Elena Kashuba, PhD Associate Professor Department of Microbiology, Tumor and Cell Biology (MTC) Karolinska Institutet 1 Epstein-Barr virus EBV Everybody s virus 200 nm Enveloped
More informationLaboratory Diagnosis of Viral Infections. G. Jamjoom 2005
Laboratory Diagnosis of Viral Infections G. Jamjoom 2005 Five Main Techniques: Virus Culture and Isolation Serology Rapid Detection of Viral Antigens Detection of Viral Nucleic Acid Electron Microscopy
More informationThe ABC s (and D & E s) of the Viral Hepatitides Part 2 DIAGNOSTIC TESTS 3/7/2013
The ABC s (and D & E s) of the Viral Hepatitides Part 2 Thomas Novicki PhD DABMM Clinical Microbiologist Division of Laboratory Medicine novicki.thomas@marshfieldclinic.org Objectives 2 1. Explain the
More informationEnzyme Immunoassay (EIA) for the Detection of EB VCA IgG Antibodies in Human Serum. For In Vitro Diagnostic Use Only
EB VCA IgG EIA ID: Black Enzyme Immunoassay (EIA) for the Detection of EB VCA IgG Antibodies in Human Serum. For In Vitro Diagnostic Use Only 25184 96 Tests CONTENTS 1 - INTENDED USE 2 - SUMMARY AND EXPLANATION
More informationSEROLOGICAL DIAGNOSIS OF VIRAL INFECTIONS:
SEROLOGICAL DIAGNOSIS OF VIRAL INFECTIONS: POSSIBILITIES OF SEROLOGICAL DIAGNOSIS TYPES OF SEROLOGICAL REACTIONS SEROLOGICAL REACTIONS Ag-Ab reactions used for the detection of unknown Ag or Ab, in vitro
More informationSchedule of Accreditation
Schedule of Accreditation Organisation Name National Virus Reference Laboratory INAB Reg No 326MT Contact Name Eimear Malone Address University College Dublin, Belfield, Dublin Contact Phone No 01-7161319
More informationPolicy # MI/SER/02/v03 Page 1 of 9 Policy & Procedure Manual
Policy # MI/SER/02/v03 Page 1 of 9 Section: Subject Title: AxSYM System Issued by: LABORATORY MANAGER Original Date: March 14, 2001 Approved by: Laboratory Director Revision Date: October 28, 2003 AXSYM
More informationEpstein-Barr Virus in a Toddler. Elaine Bullock, MD Pediatrics LSU Health Shreveport Louisiana Chapter AAP Pediatric Potpourri on the Bayou
Epstein-Barr Virus in a Toddler Elaine Bullock, MD Pediatrics LSU Health Shreveport Louisiana Chapter AAP Pediatric Potpourri on the Bayou Disclosure Presenter: Elaine Bullock, MD I have nothing to disclose
More informationSupplementary Online Content
Supplementary Online Content Peters PJ, Westheimer E, Cohen S, et al. Screening yield of HIV antigen/antibody combination and pooled HIV RNA testing for acute HIV infection in a high-prevalence population.
More informationCOMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP)
European Medicines Agency Pre-authorisation Evaluation of Medicines for Human Use London, 21 September 2006 EMEA/CHMP/BWP/298390/2005 COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) GUIDELINE ON
More informationPerformance of the ARCHITECT EBV antibody panel for the determination of Epstein-Barr
CVI Accepts, published online ahead of print on 2 April 2014 Clin. Vaccine Immunol. doi:10.1128/cvi.00754-13 Copyright 2014, American Society for Microbiology. All Rights Reserved. 1 2 3 4 5 6 7 8 9 10
More informationMaximizing Cornea and Tissue Donation through Specimen Quality
Maximizing Cornea and Tissue Donation through Specimen Quality Robert W. Bresler, Sydney D. Gastreich, Elias G. Koulouriotis, Linda S. Martin, Susan Diane Brockmeier, Chak-Sum Ho, PhD Abstract Purpose:
More informationEBV Infection and Immunity. Andrew Hislop Institute for Cancer Studies University of Birmingham
EBV Infection and Immunity Andrew Hislop Institute for Cancer Studies University of Birmingham EBV Introduction Large ds DNA virus Spread by saliva contact Lifelong infection Predominantly B-lymphotropic
More informationTrends in molecular diagnostics
Trends in molecular diagnostics Detection of target genes of interest Quantification Infectious diseases HIV Hepatitis C & B TB / MAC Cytomegalovirus Herpes simplex Varicella zoster CT/GC HPV Profiling
More informationDiagnostic Methods of HBV infection. Zohreh Sharifi,ph.D of Virology Research center, Iranian Blood Transfusion Organization (IBTO)
Diagnostic Methods of HBV infection Zohreh Sharifi,ph.D of Virology Research center, Iranian Blood Transfusion Organization (IBTO) Hepatitis B-laboratory diagnosis Detection of HBV infection involves
More informationSchedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK West of Scotland Specialist Virology Centre New Lister Building Level 5 Glasgow Royal Infirmary 10-16 Alexandra Parade Glasgow G31 2ER Contact:
More informationEC CERTIFICATE. National Institute for Biological Standards and Control (NIBSC) Blanche Lane South Mimms Potters Bar Hertfordshire EN6 3QG UK
National Institute for Biological Standards and Control (NIBSC) EC Certificate - Full Quality Assurance System Approval Certificate Annex IV (excluding sections 4 and 6) of Council Directive 98/79/EC on
More informationThis kit is intended for Research Use Only. Not for use in diagnostic procedures.
This kit is intended for Research Use Only. Not for use in diagnostic procedures. Introduction The DRG Epstein-Barr Virus (VCA) IgM Enzyme Immunoassay Kit provides materials for determination of IgM-class
More informationTreponema-Specific Tests for Serodiagnosis of Syphilis: Comparative Evaluation of Seven Assays
JOURNAL OF CLINICAL MICROBIOLOGY, Apr. 2011, p. 1313 1317 Vol. 49, No. 4 0095-1137/11/$12.00 doi:10.1128/jcm.02555-10 Copyright 2011, American Society for Microbiology. All Rights Reserved. Treponema-Specific
More informationNew HIV Tests and Algorithm: A change we can believe in
New HIV Tests and Algorithm: A change we can believe in Esther Babady, PhD, D (ABMM) Memorial Sloan-Kettering Cancer Center New York, New York Learning Objectives After this presentation you should be
More informationpatients with blood borne viruses Controlled Document Number: Version Number: 4 Controlled Document Sponsor: Controlled Document Lead:
CONTROLLED DOCUMENT Procedure for the management of patients with blood borne viruses CATEGORY: CLASSIFICATION: PURPOSE Controlled Document Number: Version Number: 4 Controlled Document Sponsor: Controlled
More informationELISA Range. VIROTECH Diagnostics GmbH. Lot independent. Reagent. System. IgG-Conjugate. Substrate. IgM-Conjugate. Washing Solution.
Quelle: www.fotolia.com ELISA Range IgG-Conjugate IgM-Conjugate IgA-Conjugate Lot independent Reagent System Stop Solution Substrate Washing Solution Serum Dilution Dilution Buffer Incubation Time Cerebrospinal
More informationHepatitis. Dr. Mohamed. A. Mahdi 5/2/2019. Mob:
Hepatitis Dr. Mohamed. A. Mahdi Mob: 0123002800 5/2/2019 Hepatitis Hepatitis means the inflammation of the liver. May cause by viruses or bacteria, parasites, radiation, drugs, chemical and toxins (alcohol).
More informationHepa%%s E Virus Is it a Concern?
IPFA/PEI 17 th Workshop on Surveillance and Screening of Blood Borne Pathogens 26-27 May 2010, The Regent Esplanade Zagreb Hotel, Zagreb, Croa%a Hepa%%s E Virus Is it a Concern? Keiji Matsubayashi Hokkaido
More informationViral hepatitis. Supervised by: Dr.Gaith. presented by: Shaima a & Anas & Ala a
Viral hepatitis Supervised by: Dr.Gaith presented by: Shaima a & Anas & Ala a Etiology Common: Hepatitis A Hepatitis B Hepatitis C Hepatitis D Hepatitis E Less common: Cytomegalovirus EBV Rare: Herpes
More informationFifteen years of molecular EQA: progress and challenges
Fifteen years of molecular EQA: progress and challenges Anton M van Loon 1, Stuart West 2 and Paul Wallace 2 1 Department of Virology, UMC Utrecht, The Netherlands 2 QCMD, Glasgow, Scotland Key Issues
More informationViral Hepatitis in Reproductive Health
Viral Hepatitis in Reproductive Health Training Course in Sexual and Reproductive Health Research Geneva 2010 Dr José M Bengoa Dr Pierre Jean Malè Consultants Division of Gastroenterology and Hepatology
More informationEvaluation of Four Commercial Systems for the Diagnosis of Epstein-Barr Virus Primary Infections
CLINICAL AND VACCINE IMMUNOLOGY, Mar. 2011, p. 444 448 Vol. 18, No. 3 1556-6811/11/$12.00 doi:10.1128/cvi.00486-10 Copyright 2011, American Society for Microbiology. All Rights Reserved. Evaluation of
More information