Salmonella Typhi Associated Hemophagocytic Lymphohistiocytosis in a Previously Healthy 23 Years Old Woman
|
|
- Harriet Houston
- 6 years ago
- Views:
Transcription
1 Article ID: WMC ISSN Salmonella Typhi Associated Hemophagocytic Lymphohistiocytosis in a Previously Healthy 23 Years Old Woman Author(s):Dr. Dina Khalaf, Dr. Bassem Toema, Dr. Shaker Al-sadadi, Dr. Fathi Al-jehani, Dr. Mohamed Sammak Corresponding Author: Dr. Dina Khalaf, MBChB, MSc, Department of Hematology and Oncology, Saad Specialist Hospital - Saudi Arabia Submitting Author: Dr. Bassem Toema, M.Sc., M.B.Ch.B, Department Of Clinical Pharmacology, University Of Oxford - United Kingdom Article ID: WMC Article Type: My opinion Submitted on:12-mar-2011, 06:22:03 AM GMT Article URL: Subject Categories:INFECTIOUS DISEASES Published on: 12-Mar-2011, 01:49:40 PM GMT Keywords:Salmonella Typhi, Hemophagocytic Lymphohistiocytosis, Pancyotpenia, Typhoid Fever, Sepsis, Bacterial Immunogenicity How to cite the article:khalaf D, Toema B, Al-sadadi S, Al-jehani F, Sammak M. Salmonella Typhi Associated Hemophagocytic Lymphohistiocytosis in a Previously Healthy 23 Years Old Woman. WebmedCentral INFECTIOUS DISEASES 2011;2(3):WMC Source(s) of Funding: On behalf of all the contributors, I declare that there is no support in financial or other manner. Competing Interests: On behalf of all the contributors, I declare that we have no conflict of interests?. Additional Files: References Cover letter WebmedCentral > My opinion Page 1 of 9
2 Salmonella Typhi Associated Hemophagocytic Lymphohistiocytosis in a Previously Healthy 23 Years Old Woman My opinion A previously healthy 23 years old female was admitted with fever. All the clinical and laboratory findings of the patient are summarized in Table 1. Blood culture revealed Salmonella typhi. Bone marrow aspirate showed hemophagocytosis (figures 1 and 2). The patient received fluoroquinolone, intravenous pentaglobulins for 4 days and intravenous dexamethasone for 8 days. There was marked clinical and biochemical improvement (graphs 1, 2 and 3). Suggestive evidence linking Hemophagocytic Lymphohistiocytosis (HLH) to Typhoid fever include: 1. Differentiating HLH from similar blood diseases According to the Histiocyte Society guidelines, five out of eight criteria should be fulfilled for establishing diagnosis of HLH. The history of persistent high grade fever, physical examination and CT scans that revealed hepatosplenomegaly, pancytopenia, associated transaminitis, hypofibrinogenemia and elevated Lactate dehydrogenase and ferritin levels supported the evidence for HLH besides the histopathological confirmation of hemophagocytosis by bone marrow examination. Peripheral smear didn t show fragmentation or schistocytes excluding thrombotic thrombocytopenic purpura. [1] 2. Exploring other possible causes of HLH Complete viral screen for Cytomegalovirus, Epstein Barr virus, Hepatitis B and C Viruses, and Human Immunodeficiency Viruses 1 and 2 was negative. Antinuclear antibody, Double stranded DNA antibody, Rheumatoid Factor and Anti Neutrophil Cytoplasmic Antibody were negative ruling out the macrophage activation syndrome. 3. Positive temporal relationship and biological plausibility Hemophagocytosis is non-specific frequent pathologic finding in the active proliferative stage of typhoid fever which coincides with the second week of infection. [2] 4. Recognized association with Gram negative aerobic bacilli Brucella is a genus of Gram negative, non motile, non spore-forming bacilli. In a pivotal case-control study, 16 patients (5.8%) out of 276 pediatric cases of brucellosis seen over a 7-year period were found to have pancytopenia. Fourteen out of these 16 patients (87.5%) had positive blood and / or bone marrow cultures for Brucella melitensis. Also hemophagocytosis was observed in 14 out of these 16 patients (87.5%). [3] Typhoid fever is rarely associated with HLH. In one study the bone marrow of four cases (out of fifteen cases of culture proven typhoid fever) was examined and showed infection associated Hemophagocytic syndrome. In another study, the bone marrow examinations of five patients with Typhoid fever associated with pancytopenia revealed histiocytic hyperplasia with marked phagocytosis of platelets, leukocytes and red blood cells in those affected individuals. [4][5] 5. Identification of Salmonella typhi with blood culture. In conclusion, in areas where typhoid fever prevalence is high, hemophagocytic findings should be considered Salmonella typhi associated HLH until proven otherwise. References 1.Janka Gritta. Familial and acquired hemophagocytic lymphohistiocytosis. Eur J Pediatr 2007; 166: B. Frisch, S.M. Lewis, R. Burkhardt, R. Barti. Biopsy Pathology of Bone and Bone Marrow - Biopsy Pathology Series Chapman and Hall Medical. 1985; Al-Eissa YA, Assuhaimi SA, Al-Fawaz IM, Higgy KE, Al-Nasser MN, Al-Mobaireek KF. Pancytopenia in children with brucellosis: clinical manifestations and bone marrow findings. Acta Haematol. 1993; 89: WebmedCentral > My opinion Page 2 of 9
3 4.Shin BM, Paik IK, Cho HI. Bone marrow pathology of culture proven typhoid fever. J Korean Med Sci. 1994; 9: Udden MM, Bañez E, Sears DA. Bone marrow histiocytic hyperplasia and hemophagocytosis with pancytopenia in typhoid fever. Am J Med Sci. 1986; 291: WebmedCentral > My opinion Page 3 of 9
4 Illustrations Illustration 1 Clinical / Laboratory Findings Table 1. Clinical and Laboratory manifestations High grade fever of one week duration associated Fever with chills, rigors, nausea, vomiting and asthenia Splenomegaly Hepatomegaly Computerized tomography (CT) scan of the abdomen Physical examination and CT scan of the abdomen Leucopenia Total white cell count 2170 / microliter (reference: ,000) Neutropenia Absolute neutrophilic count 1800 / microliter (reference: ) Anemia Hemoglobin level 8.7 gram / deciliter (reference: ) Thrombocytopenia Platelet count 44,000 / microliter (reference: 140, ,000) Prothrombin time 18.4 seconds (reference: ) Coagulopathy International Normalized Ratio 1.4 (reference: ) Partial thromboplastin time 46.2 seconds (reference: ) Hypofibrinogenemia Fibrinogen level 135 milligrams / liter (reference: ) Renal impairment Creatinine level 248 micromol / liter (reference: 53-97) Aspartate Transaminase level 170 International Unit / liter (reference: Transaminitis 14-36) Alanine Transaminase level 54 International Unit / liter (reference: 9-52) WebmedCentral > My opinion Page 4 of 9 Serum lactate dehydrogenase level 934 units / liter (reference: )
5 Illustration 2 Figure 1: Histopathological examination of bone marrow aspiration showing Macrophage engulfing blood cells Illustration 3 Figure 2: Histopathological examination of bone marrow aspiration showing Macrophage engulfing blood cells WebmedCentral > My opinion Page 5 of 9
6 Illustration 4 Graph 1: Line graph of total white cell count and absolute neutrophilic count versus time from day 1 intravenous immunoglobulins to day 8 intravenous immunoglobulins Illustration 5 Graph 2: Line graph of hemoglobin level versus time from day 1 intravenous immunoglobulins to day 8 intravenous immunoglobulins WebmedCentral > My opinion Page 6 of 9
7 Illustration 6 Graph 3: Line graph of platelet count versus time from day 1 intravenous immunoglobulins to day 8 intravenous immunoglobulins WebmedCentral > My opinion Page 7 of 9
8 Illustration 7 Table 1. Clinical and Laboratory manifestations Clinical / Laboratory Findings High grade fever of one week duration associated Fever with chills, rigors, nausea, vomiting and asthenia Splenomegaly Hepatomegaly Computerized tomography (CT) scan of the abdomen Physical examination and CT scan of the abdomen Leucopenia Total white cell count 2170 / microliter (reference: ,000) Neutropenia Absolute neutrophilic count 1800 / microliter (reference: ) Anemia Hemoglobin level 8.7 gram / deciliter (reference: ) Thrombocytopenia Platelet count 44,000 / microliter (reference: 140, ,000) Prothrombin time 18.4 seconds (reference: ) Coagulopathy International Normalized Ratio 1.4 (reference: ) Partial thromboplastin time 46.2 seconds (reference: ) Hypofibrinogenemia Fibrinogen level 135 milligrams / liter (reference: ) Renal impairment Creatinine level 248 micromol / liter (reference: 53-97) Aspartate Transaminase level 170 International Unit / liter (reference: 14-36) Transaminitis Alanine Transaminase level 54 International Unit / liter (reference: 9-52) Serum lactate dehydrogenase level 934 units / liter (reference: ) Haemolysis Haptoglobin level less than 0.28 gram / liter (reference: ) Hyperferritinemia Ferritin level 6485 nanograms / milliliter (reference: 7-83) WebmedCentral Acute Inflammatory > My opinion Page 8 of 9 C-reactive protein level 264 milligrams / liter (reference: ) response
9 Disclaimer This article has been downloaded from WebmedCentral. With our unique author driven post publication peer review, contents posted on this web portal do not undergo any prepublication peer or editorial review. It is completely the responsibility of the authors to ensure not only scientific and ethical standards of the manuscript but also its grammatical accuracy. Authors must ensure that they obtain all the necessary permissions before submitting any information that requires obtaining a consent or approval from a third party. Authors should also ensure not to submit any information which they do not have the copyright of or of which they have transferred the copyrights to a third party. Contents on WebmedCentral are purely for biomedical researchers and scientists. They are not meant to cater to the needs of an individual patient. The web portal or any content(s) therein is neither designed to support, nor replace, the relationship that exists between a patient/site visitor and his/her physician. Your use of the WebmedCentral site and its contents is entirely at your own risk. We do not take any responsibility for any harm that you may suffer or inflict on a third person by following the contents of this website. WebmedCentral > My opinion Page 9 of 9
Supracondylar Process Congenitalis Of The Femur
Article ID: WMC00544 ISSN 2046-1690 Supracondylar Process Congenitalis Of The Femur Author(s):Dr. S S Suresh Corresponding Author: Dr. S S Suresh, Head of Department, IBRI Regional Referral Hospital, Department
More informationInfiltrative Brain Mass Due To Progressive Alzheimer's Disease
Article ID: WMC00505 2046-1690 Infiltrative Brain Mass Due To Progressive Alzheimer's Disease Corresponding Author: Dr. Mark Lyons, Associate Professor, Mayo Clinic Arizona, 85054 - United States of America
More informationSignet-Ring Cell Change in Benign Prostatic Hyperplasia - A Rare Case Report
Article ID: WMC00688 ISSN 2046-1690 Signet-Ring Cell Change in Benign Prostatic Hyperplasia - A Rare Case Report Author(s):Dr. Pallavi Bhuyan, Dr. Smita Mahapatra, Dr. Sujata Pujari, Dr. Jayasree Rath
More informationMore HIV Infection Among Housewvies Than Sex Workers In Malaysia
Article ID: WMC001557 ISSN 2046-1690 More HIV Infection Among Housewvies Than Sex Workers In Malaysia Corresponding Author: Mr. Mohamed Najimudeen, Associate Professor, Obstetrics and Gynaecology, Melaka
More informationBook Review: The Role of Education in the Rational use of Medicines
Article ID: WMC002475 ISSN 2046-1690 Book Review: The Role of Education in the Rational use of Medicines Corresponding Author: Dr. P Ravi Shankar, Professor, Medical Education, Pharmacology, KIST Medical
More informationCorresponding Author: Dr. Simon B Thompson, Associate Professor, Psychology Research Centre, Bournemouth University, BH12 5BB - United Kingdom
Article ID: 2046-1690 Thompson Digital Switch: Helping Stroke Patients to Help Themselves by Promoting Proprioception During Therapy. Brief Report and Podcast as a Teaching Aid for Professionals Corresponding
More informationDumbbell Ganglion Of The Foot: Case Report
Article ID: WMC001079 2046-1690 ISSN Dumbbell Ganglion Of The Foot: Case Report Author(s):Dr. S S Suresh, Dr. Hosam Zaki, Dr. Joyce Jose Corresponding Author: Dr. S S Suresh, Head of Department, Ibri Regional
More informationA Case of Incisiform Supernumerary Tooth Along With a Impacted Supplemental Tooth In Anterior Maxillary Region
Article ID: WMC004147 ISSN 2046-1690 A Case of Incisiform Supernumerary Tooth Along With a Impacted Supplemental Tooth In Anterior Maxillary Region Corresponding Author: Dr. Keshav K Gautam, Service Senior
More informationRisk Factors Predicting Mortality in Spinal Cord Injury in Nigeria
Article ID: WMC00807 ISSN 2046690 Risk Factors Predicting Mortality in Spinal Cord Injury in Nigeria Corresponding Author: Dr. Ahidjo Kawu, Consultant Surgeon, Dept of Orthopaedics, UATH, Gwagwalada Abuja
More informationBilateral Adrenal Myelolipoma: A Case Report and Review of Literature
Article ID: WMC004085 ISSN 2046-1690 Bilateral Adrenal Myelolipoma: A Case Report and Review of Literature Corresponding Author: Dr. Karthikeyan Selvaraju, Assistant Professor, Kasturba Medical College,
More informationVariation of Superficial Palmar Arch: A Case Report
Article ID: WMC003387 ISSN 2046-1690 Variation of Superficial Palmar Arch: A Case Report Corresponding Author: Dr. Liju S Mathew, Demonstrator, Anatomy, Gulf Medical University, 4184 - United Arab Emirates
More informationEthics in Prehospital Emergency Medicine: An Ethical Dilemma in Patient Communication
Article ID: WMC004247 ISSN 2046-1690 Ethics in Prehospital Emergency Medicine: An Ethical Dilemma in Patient Communication Corresponding Author: Prof. Halvor Nordby, The University of Oslo, Faculty of
More informationSignet-Ring Cell Change in Benign Prostatic Hyperplasia - A Rare Case Report
Article ID: WMC00688 ISSN 2046-1690 Signet-Ring Cell Change in Benign Prostatic Hyperplasia - A Rare Case Report Author(s):Dr. Pallavi Bhuyan, Dr. Smita Mahapatra, Dr. Sujata Pujari, Dr. Jayasree Rath
More informationBipartite Patella: Two Cases Reports
Article ID: WMC003501 ISSN 2046-1690 Bipartite Patella: Two Cases Reports Corresponding Author: Dr. Fadwa Chami, Doctor, Hopital Denfants de Rabat - Morocco Submitting Author: Dr. Fadwa Chami, Doctor,
More informationRadical Prostatectomy Does Not Increase the Risk of Inguinal Hernia
Article ID: WMC003763 ISSN 2046-1690 Radical Prostatectomy Does Not Increase the Risk of Inguinal Hernia Corresponding Author: Dr. Dan Spernat, Senior Lecturer University of Adelaide Urological Surgeon,
More informationCorresponding Author: Dr. Simon B Thompson, Associate Professor, Psychology Research Centre, Bournemouth University, BH12 5BB - United Kingdom
Article ID: 2046-1690 Thompson Digital Switch: Helping Stroke Patients to Help Themselves by Promoting Proprioception During Therapy. Brief Report and Podcast as a Teaching Aid for Professionals Corresponding
More informationBaseline Characteristics of Patients Attending the Memory Clinic Serving the South Shore of Boston
Article ID: ISSN 2046-1690 Baseline Characteristics of Patients Attending the www.thealzcenter.org Memory Clinic Serving the South Shore of Boston Corresponding Author: Dr. Anil K Nair, Chief of Neurology,
More informationArticle ID: WMC00791 ISSN
Article ID: WMC00791 ISSN 2046-1690 Shoe-smell Application as a First-aid Interventional Measure in Controlling Epileptic Attacks in an Urban Population in India: A Fortuitous Empirical Finding Author(s):Dr.
More informationArticle ID: WMC
Article ID: WMC001971 2046-1690 Evaluation of Visual Inspection with Acetic Acid (Via) & Visual Inspection with Lugol's Iodine (Vili) as a Screening Tool for Cervical Intraepithelial Neoplasia in Comparison
More informationIntroduction to Cofilin and its Regulation of Actin Dynamics
Article ID: ISSN 2046-1690 Introduction to Cofilin and its Regulation of Actin Dynamics Author(s):Mr. Kuen Yeow Chin Corresponding Author: Mr. Kuen Yeow Chin, MSc, Department of Cell and Developmental
More informationAdult Intussception : A Case Report
Article ID: ISSN 2046-1690 Adult Intussception : A Case Report Author(s):Dr. C Surendranath Singh, Prof. M.l. Prakash Corresponding Author: Dr. C Surendranath Singh, Senior Lecturer, Unit of Radiodiagnosis,
More informationThe Role Of Varma Therapy In Cakana Vatam
Article ID: WMC002906 ISSN 2046-1690 The Role Of Varma Therapy In Cakana Vatam Corresponding Author: Dr. Shanmugasundaram Natarajan, Consultant Varmam Therapy, Siddha Regional Research Institute - India
More informationPilot Of Spontaneous Breathing Vs. Ventilated Model For Hemorrhage And Resuscitation In The Rabbit
Article ID: WMC001137 Pilot Of Spontaneous Breathing Vs. Ventilated Model For Hemorrhage And Resuscitation In The Rabbit Author(s):Dr. Jonathan S. Jahr, MD, Dr. Robert A. Gunther, PhD, Dr. Bernd Driessen,
More informationThe Viability Of Human Embryos After Transport In A Dry Shipper Between Assisted Conception Laboratories
Article ID: WMC001104 2046-1690 The Viability Of Human Embryos After Transport In A Dry Shipper Between Assisted Conception Laboratories Corresponding Author: Ms. Clare Pinkus, Scientist, Hollywood Fertility
More informationVascular Risk Factors in Left Colon Anastomosis Leakage: A Computed Tomography Guided Study
Article ID: WMC003346 ISSN 2046-1690 Vascular Risk Factors in Left Colon Anastomosis Leakage: A Computed Tomography Guided Study Corresponding Author: Dr. Antonio Manenti, Associate Professor, Department
More informationHemophagocytic Lymphohistiocytosis Pre-HCT Data
Instructions for Hemophagocytic Lymphohistiocytosis Pre-HCT Data (Form 2039) This section of the CIBMTR Forms Instruction Manual is intended to be a resource for completing the Hemophagocytic Lymphohistiocytosis
More informationBipartite Patella: Two Cases Reports
Article ID: WMC003501 ISSN 2046-1690 Bipartite Patella: Two Cases Reports Corresponding Author: Dr. Fadwa Chami, Doctor, Hopital Denfants de Rabat - Morocco Submitting Author: Dr. Fadwa Chami, Doctor,
More informationGorham Disease an Enigma
Article ID: WMC002898 ISSN 2046-1690 Gorham Disease an Enigma Corresponding Author: Dr. Prashant Kothari, Asso Professor, ODMR MCDRC, 442301 - India Submitting Author: Dr. Prashant Kothari, Asso Professor,
More informationWarm Autoantibodies in a Patient with Hemophagocytic Lymphohistiocytosis: A Case Report
Warm Autoantibodies in a Patient with Hemophagocytic Lymphohistiocytosis: A Case Report Emily Coberly, MD Department of Pathology and Anatomical Sciences University of Missouri Columbia April 30, 2013
More informationProfile of Hemophagocytic Lymphohistiocytosis in Children in a Tertiary Care Hospital in India
R E S E A R C H P A P E R Profile of Hemophagocytic Lymphohistiocytosis in Children in a Tertiary Care Hospital in India B RAMACHANDRAN, S BALASUBRAMANIAN, N ABHISHEK, KG RAVIKUMAR AND AV RAMANAN* From
More informationCaeco-colic Intussusception Simulating an Appendicular Mass
Article ID: WMC003206 ISSN 2046-1690 Caeco-colic Intussusception Simulating an Appendicular Mass Corresponding Author: Dr. Matthew O Adelekan, Surgeon, North manchester General Hospital - United Kingdom
More informationDoes Morphology Matter in 2017
Does Morphology Matter in 2017 ISLH May 2017 Kathryn Foucar Distinguished Professor Emerita kfoucar@salud.unm.edu Objectives Recognize unique RBC and WBC abnormalities in non-neoplastic disorders Learn
More informationEndoscopic Detection and Removal of Recto-sigmoid Myomatous (Leiomyoma) Tumour
Article ID: ISSN 2046-1690 Endoscopic Detection and Removal of Recto-sigmoid Myomatous (Leiomyoma) Tumour Author(s):Mr. Sridhar Dharamavaram, Dr. Ritu Kamra, Dr. Anu Priya, Mr. Rajiva Ranjan Das Corresponding
More informationHemophagocytosis on Bone Marrow Aspirate Cytology: Single Center Experience in North Himalayan Region of India
Original Article Hemophagocytosis on Bone Marrow Aspirate Cytology: Single Center Experience in North Himalayan Region of India Chandra H, Chandra S, Kaushik RM 1, Bhat NK 2, Shrivastava V Departments
More informationScientific Misconduct
Article ID: WMC001719 ISSN 2046-1690 Scientific Misconduct Corresponding Author: Dr. Ulysses P Albuquerque, Professor, Universidade Federal Rural de Pernambuco - Brazil Submitting Author: Dr. Ulysses P
More informationCity Pediatric Meet-Dec 2011 SPECTRUM OF HLH. Spectrum of HLH. Dr.Revathi Raj s unit, Apollo Children s Hospital.
City Pediatric Meet-Dec 2011 SPECTRUM OF HLH Spectrum of HLH Dr.Revathi Raj s unit, Apollo Children s Hospital. Case 1 4 month male child /thriving well Fever - 5 days with cough O/E hepatospenomegaly
More informationEpstein-Barr Virus Infection Associated With Bone Marrow Fibrin-Ring Granuloma
Hematopathology / EBV-Associated BM Fibrin-Ring Granuloma Epstein-Barr Virus Infection Associated With Bone Marrow Fibrin-Ring Granuloma Hee-Jung Chung, MD, Hyun-Sook Chi, MD, Seongsoo Jang, MD, and Chan-Jeoung
More informationHemophagocytosis on Bone Marrow Aspirate Cytology: Single Center Experience in North Himalayan Region of India
Original Article Hemophagocytosis on Bone Marrow Aspirate Cytology: Single Center Experience in North Himalayan Region of India Chandra H, Chandra S, Kaushik RM 1, Bhat NK 2, Shrivastava V Departments
More informationStatistical Methods for Modeling HIV/AIDS in India
Article ID: WMC003336 ISSN 2046-1690 Statistical Methods for Modeling HIV/AIDS in India Corresponding Author: Dr. Brijesh Sathian, Assistant Professor & Managing and Chief Editor NJE, Community Medicine,
More informationFatal Haemophagocytic Syndrome
Fatal Haemophagocytic Syndrome SAW Fadl1ah, MMed', A A Raymond, MD", S K Cheong, FRCPA', MAL Amir, MD', 'Division ofclinical Haematology and Stem celltt'ansplantation, "Division ofneurology, Faculty of
More informationScientific Misconduct
Article ID: WMC001617 2046-1690 Scientific Misconduct Corresponding Author: Dr. Ulysses P Albuquerque, Professor, Universidade Federal Rural de Pernambuco - Brazil Submitting Author: Dr. Ulysses P Albuquerque,
More informationAcute Immune Thrombocytopenic Purpura (ITP) in Childhood
Acute Immune Thrombocytopenic Purpura (ITP) in Childhood Guideline developed by Robert Saylors, MD, in collaboration with the ANGELS team. Last reviewed by Robert Saylors, MD September 22, 2016. Key Points
More informationArticle ID: WMC00596 ISSN
Article ID: WMC00596 ISSN 2046-1690 "Radio-Ulnar Synostosis Following Isolated Fracture Of Shaft Of Ulna And Its Treatment By Radical Excision And Interposition Of Tensor Fascia Lata Graft" Author(s):Dr.
More informationMorphology Case Study. Presented by Niamh O Donnell, BSc, MSc. Medical Scientist Haematology Laboratory Cork University Hospital
Morphology Case Study Presented by Niamh O Donnell, BSc, MSc. Medical Scientist Haematology Laboratory Cork University Hospital 41 year old male presented to GP for routine check-up in May 2011. FBC Results:
More informationTrichotillomania With Gastroduodenojejunal Trichobezoar
Article ID: WMC001367 2046-1690 Trichotillomania With Gastroduodenojejunal Trichobezoar Corresponding Author: Dr. Sanjay Somani, Consultant Gastroenterologist, Gastroenterology Department, Sahara Hospital,
More informationSplenic Flexure Volvulus Presenting with Peritonitis: Case Report and Review of the Literature.
Article ID: WMC003974 ISSN 2046-1690 Splenic Flexure Volvulus Presenting with Peritonitis: Case Report and Review of the Literature. Corresponding Author: Dr. Gianrocco Manco, General Surgeon, Clinica
More informationDexamethasone Compared with Metoclopramide in Prevention of Postoperative Nausea and Vomiting in Orthognathic Surgery
Article ID: WMC002013 2046-1690 Dexamethasone Compared with Metoclopramide in Prevention of Postoperative Nausea and Vomiting in Orthognathic Surgery Corresponding Author: Dr. Agreta Gashi, Anesthesiologist,
More informationKINDL Quality Of Life Questionnaire In Serbia: Referent Values For Healthy Children And Adolescents
Article ID: WC001342 2046-1690 KINDL Quality Of Life Questionnaire In Serbia: Referent Values For Healthy Children And Adolescents Corresponding Author: Dr. Dejan Stevanovic, Researcher/clinician, Psychiatry,
More informationRecurrent Fibrolipoma of the Left Thigh - A Case Report
Article ID: WMC003378 ISSN 2046-1690 Recurrent Fibrolipoma of the Left Thigh - A Case Report Corresponding Author: Dr. Mohanad M Sultan, Specialist in Surgery, Dept. of General Surgery, Gulf Medical College
More informationPsoriasis Penis - A Two Case Report
Article ID: WMC003176 ISSN 2046-1690 Psoriasis Penis - A Two Case Report Corresponding Author: Dr. Ilko Bakardzhiev, MD, PhD, Medical College, Medical University of Varna, 9000 - Bulgaria Submitting Author:
More informationINFECTION-ASSOCIATED HEMOPHAGOCYTIC SYNDROME
INFECTION-ASSOCIATED HEMOPHAGOCYTIC SYNDROME Z.E. Currimbhoy ABSTRACT An epidemic of an infection associated with circulating hemophagocytes (HP) and activated monocytes (AM) was seen in Bombay. Although
More informationHuman herpesvirus-8 related hemophagocytic lymphohistiocytosis with Kaposi sarcoma in an immunocompetent HIV negative adult
www.edoriumjournals.com CASE REPORT PEER REVIEWED OPEN ACCESS Human herpesvirus-8 related hemophagocytic lymphohistiocytosis with Kaposi sarcoma in an immunocompetent HIV negative adult Talal Alnabelsi,
More informationDiffuse large B-cell lymphoma in an adolescent female presenting with Epstein-Barr virus-driven hemophagocytic lymphohistiocytosis: a case report
Altaf et al. Journal of Medical Case Reports 2012, 6:141 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Diffuse large B-cell lymphoma in an adolescent female presenting with Epstein-Barr virus-driven
More informationCompliance with Sleep Instructions After Total Hip Arthroplasty
Article ID: WMC002164 ISSN 2046-1690 Compliance with Sleep Instructions After Total Hip Arthroplasty Corresponding Author: Mr. Chetan S Modi, Registrar Trauma and Orthopaedic Surgery, Heart of England
More informationProfile of Hemophagocytic Lymphohistiocytosis; Efficacy of Intravenous Immunoglobulin Therapy
Indian J Pediatr (December 2014) 81(12):1337 1341 DOI 10.1007/s12098-014-1461-0 ORIGINAL ARTICLE Profile of Hemophagocytic Lymphohistiocytosis; Efficacy of Intravenous Immunoglobulin Therapy Sarala Rajajee
More informationThis was a multicenter study conducted at 11 sites in the United States and 11 sites in Europe.
Protocol CAM211: A Phase II Study of Campath-1H (CAMPATH ) in Patients with B- Cell Chronic Lymphocytic Leukemia who have Received an Alkylating Agent and Failed Fludarabine Therapy These results are supplied
More informationHemophagocytic Lymphohistiocytosis Secondary to T cell/histiocyte-rich Large B-cell Lymphoma
Hemophagocytic Lymphohistiocytosis Secondary to T cell/histiocyte-rich Large B-cell Lymphoma Katherine Devitt, M.D., Benjamin Chen, M.D., Ph.D., Hongbo Yu, M.D., Ph.D., Bruce Woda, M.D. 1 1 Department
More informationUnderstanding of Oral Cancer Risk in Male Population of Guntur with Tobacco Habits?
Article ID: WMC003313 ISSN 2046-1690 Understanding of Oral Cancer Risk in Male Population of Guntur with Tobacco Habits? Corresponding Author: Dr. Madu G Prasad, Professor and HOD, Pedodontics and Preventive
More informationAn Interesting Case Of Atrial Septal Defect, Patent Urachus And Valvular Anus Presenting In Adulthood
Article ID: 2046-1690 An Interesting Case Of Atrial Septal Defect, Patent Urachus And Valvular Anus Presenting In Adulthood Corresponding Author: Dr. Abhishek Shah, Resident, KMC Mangalore Manipal University,
More informationhemophagocytic lymphohistiocytosis; refractory celiac disease; ebstein barr virus; cutaneous leukocytoclastic vasculitis; immunocompromised patient
Open Journal of Clinical & Medical Case Reports Volume 3 (2017) Issue 23 ISSN 2379-1039 Hemophagocytic syndrome EBV-related associated with leukocytoclastic vasculitis in a type-2 refractory celiac patient
More informationCLINICAL PROFILE REVIEW OF PATIENTS WITH THROMBOCYTOPENIA: A STUDY OF 100 CASES AT A TERTIARY CARE CENTRE
IJCRR Section: Healthcare Sci. Journal Impact Factor 4.016 Research Article CLINICAL PROFILE REVIEW OF PATIENTS WITH THROMBOCYTOPENIA: A STUDY OF 100 CASES AT A TERTIARY CARE CENTRE Shah H. R. 1, Vaghani
More informationDexamethasone Compared with Metoclopramide in Prevention of Postoperative Nausea and Vomiting in Orthognathic Surgery
Article ID: WMC002013 2046-1690 Dexamethasone Compared with Metoclopramide in Prevention of Postoperative Nausea and Vomiting in Orthognathic Surgery Corresponding Author: Dr. Agreta Gashi, Anesthesiologist,
More informationHỘI CHỨNG THỰC BÀO MÁU. (HEMOPHAGOCYTIC LYMPHOHISTOCYTOSIS)
HỘI CHỨNG THỰC BÀO MÁU. (HEMOPHAGOCYTIC LYMPHOHISTOCYTOSIS) INTRODUTION. An aggressive and life-threatening syndrome of excessive immune activation. Was described in 1952. Most frequently affects infants
More informationCytopenias and clonal expansion of gamma/delta T-cells in a patient with anaplasmosis: a potential diagnostic pitfall.
J Clin Exp Hematop Vol. 56, No. 3, March 2017 Case Study Cytopenias and clonal expansion of gamma/delta T-cells in a patient with anaplasmosis: a potential diagnostic pitfall. Daniel Marko, 1) Anamarija
More informationSPARN Guidelines for Initial Diagnosis of Macrophage Activation Syndrome
Background SPARN Guidelines for Initial Diagnosis of Macrophage Activation Syndrome MAS requires prompt recognition and aggressive treatment to prevent fatalities from this rare complication of rheumatological
More informationSkin Pathway Group Alemtuzumab in Cutaneous Lymphoma
Skin Pathway Group Alemtuzumab in Cutaneous Lymphoma Indication: Treatment of patients with Cutaneous Lymphoma (Unlicensed use) Disease control prior to Reduced Intensity Conditioning Stem Cell Transplant
More informationTamsulosin-induced-priapism: A Rare Complication Associated With The Management Of Ureteric Colic.
Article ID: WMC001277 Tamsulosin-induced-priapism: A Rare Complication Associated With The Management Of Ureteric Colic. Author(s):Dr. Anthony Venyo Corresponding Author: Dr. Anthony Venyo, Urologist,
More informationThe "Ultra Low" Duodenal Stump and its Difficult Management: An Old Technique Revisited
Article ID: WMC001998 2046-1690 The "Ultra Low" Duodenal Stump and its Difficult Management: An Old Technique Revisited Corresponding Author: Dr. Antonio Manenti, Associate Professor, Department Surgery
More informationUNUSUAL PRESENTATION OF AN USUAL CAUSE OF THROMBOCYTOPENIA SOUTHERN RAILWAY HQ HOSPITAL, PERAMBUR DR. KUMARAN DNB PG
UNUSUAL PRESENTATION OF AN USUAL CAUSE OF THROMBOCYTOPENIA SOUTHERN RAILWAY HQ HOSPITAL, PERAMBUR DR. KUMARAN DNB PG 5 months old female infant hailing from Thoothukudi brought by her mother referred from
More informationEffects of Smoking on Serum Lecithin: Cholesterol Acyltransferase Activity
Article ID: WMC004169 ISSN 2046-1690 Effects of Smoking on Serum Lecithin: Cholesterol Acyltransferase Activity Corresponding Author: Dr. K K Kshitiz, Assistant Professor, Biochemistry LHMC, G Block Patel
More informationAcute kidney injury induced by thrombotic microangiopathy in a patient with hemophagocytic lymphohistiocytosis
Bae et al. BMC Nephrology (2016) 17:4 DOI 10.1186/s12882-015-0217-z CASE REPORT Open Access Acute kidney injury induced by thrombotic microangiopathy in a patient with hemophagocytic lymphohistiocytosis
More informationSmall Bowel Mechanical Occlusion and Computed Tomography Severity Indicators: What to Look for
Article ID: WMC003459 ISSN 2046-1690 Small Bowel Mechanical Occlusion and Computed Tomography Severity Indicators: What to Look for Corresponding Author: Dr. Antonio Manenti, Associate Professor, Department
More informationCoronary Angiographic Findings of Nepalese Patients with Critical Coronary Artery Disease: Which Vessels and How Severe?
Article ID: WMC002864 ISSN 2046-1690 Coronary Angiographic Findings of Nepalese Patients with Critical Coronary Artery Disease: Which Vessels and How Severe? Corresponding Author: Dr. Bharat Rawat, Managing
More informationKnowledge and Beliefs about HIV/AIDS among Adolescents
Article ID: WMC002830 2046-1690 Knowledge and Beliefs about HIV/AIDS among Adolescents Corresponding Author: Dr. Suneel Mundkur, Associate Professor, Pediatrics, KMC Manipal - India Submitting Author:
More informationExtreme hyperferritinemia in the setting of acute myeloid leukaemia: a case report of hemophagocytic lymphohistiocytosis
Case report Extreme hyperferritinemia in the setting of acute myeloid leukaemia: a case report of hemophagocytic lymphohistiocytosis Damien Denimal* 1, Louise Ménégaut 1, Cédric Rossi 2, Laurence Duvillard
More informationHAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN A GHANAIAN CHILD
HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN A GHANAIAN CHILD C. I. SEGBEFIA 1, 2, A. OSEI-WUSU 2, W. OBENG 2 and Y. DEI-ADOMAKOH 3 1 University of Ghana Medical School, Accra, Ghana, 2 Department of Child Health,
More informationINVESTIGATION OF ADVERSE TRANSFUSION REACTIONS TABLE OF RECOMMENDED TESTS. Type of Reaction Presentation Recommended Tests Follow-up Tests
Minor Allergic (Urticarial) Urticaria, pruritis, flushing, rash If skin reaction only and mild hives/ rash
More informationThings to never miss in the office. Brett Houston MD FRCPC (PYG-5, hematology) Leonard Minuk MD FRCPC
Things to never miss in the office Brett Houston MD FRCPC (PYG-5, hematology) Leonard Minuk MD FRCPC Presenter Disclosure Faculty / Speaker s name: Brett Houston / Leonard Minuk Relationships with commercial
More informationPrimitive Heart Undifferenciated Sarcoma: A case Report and Literature Review
Article ID: WMC003579 ISSN 2046-1690 Primitive Heart Undifferenciated Sarcoma: A case Report and Literature Review Corresponding Author: Dr. Hind El Yacoubi, Doctor, Medical Oncology Departement National
More informationLiver Functions as a marker of severity of disease in children with Dengue fever
Article ID: WMC004962 ISSN 2046-1690 Liver Functions as a marker of severity of disease in children with Dengue fever Peer review status: No Corresponding Author: Dr. Sampada A Tambolkar, Associate Professor,
More informationCervical Cytology at a Teaching Hospital in Northern Ngeria
Article ID: WMC002496 ISSN 2046-1690 Cervical Cytology at a Teaching Hospital in Northern Ngeria Corresponding Author: Dr. Emeka E Ojiyi, FWACS,FMCOG,FICS., Obstetrics and Gynaecology; Imo State University
More informationTwo Level Vertebral Osteomyelitis Without Spinal Epidural Abscess Secondary to Spinal and Epidural Anesthesia: Two Case
Article ID: WMC003938 ISSN 2046-1690 Two Level Vertebral Osteomyelitis Without Spinal Epidural Abscess Secondary to Spinal and Epidural Anesthesia: Two Case Corresponding Author: Dr. Ergun Karavelioglu,
More informationBi-columnar Plating For Supracondylar Fracture Extending Into Humeral Shaft : A Report Of Three Case And Literature Review
Article ID: WMC001214 2046-1690 Bi-columnar Plating For Supracondylar Fracture Extending Into Humeral Shaft : A Report Of Three Case And Literature Review Corresponding Author: Dr. Chander Bhushan, Postgraduate
More informationThe Construct Validity and Internal Consistency of the Adult Learning Inventory (AL-i) among Medical Students
Article ID: WMC00648 ISSN 2046-1690 The Construct Validity and Internal Consistency of the Adult Learning Inventory (AL-i) among Medical Students Author(s):Dr. Muhamad Saiful Bahri Yusoff Corresponding
More information(anemia) ก hemoglobin concentration, hematocrit deviation 1 1 ก hemoglobin, hematocrit mean corpuscular volume (MCV) 2
ก ก. ก ก.. ก (anemia) ก hemoglobin concentration, hematocrit ก ก ก 2 Standard deviation 1 1 ก hemoglobin, hematocrit mean corpuscular volume (MCV) 2 Hemoglobin hematocrit MCV (g/dl) (%) (fl) ( ) 0.5-1.9
More informationCase Report Hemophagocytic Syndrome Associated with Hodgkin s Lymphoma First Presenting as Fever and Pancytopenia
Case Reports in Medicine Volume 2010, Article ID 759651, 4 pages doi:10.1155/2010/759651 Case Report Hemophagocytic Syndrome Associated with Hodgkin s Lymphoma First Presenting as Fever and Pancytopenia
More informationThrombotic Microangiopathies
Thrombotic Microangiopathies ASH/San Antonio Breast Cancer Symposium Review James N. George March 14, 2015 Thrombotic Microangiopathies (TMA): Everything you need to know from 5 patient stories Thrombotic
More informationSouth African HIV Clinicians Society Managing adult treatment through case study discussion
South African HIV Clinicians Society Managing adult treatment through case study discussion Jade Mogambery Grey s Hospital, Pietermaritzburg Infectious Diseases Unit Referral summary 20-year-old male HIV
More informationHemophagocytic lymphohistiocytosis (HLH), also known
ORIGINAL ARTICLES 2 218 Epstein-Barr Virus-associated Hemophagocytic Lymphohistiocytosis in Adults: A Retrospective Analysis of 23 Patients in China Xiaoyan Shao MD 1 *, Ye Xu MD 2 *, Xihui Xu MD 1, Yong
More informationHemophagocytic Lymphohistiocytosis CASE 07-5
CASE STUDIES IN CLINICAL LABORATORY SCIENCE Hemophagocytic Lymphohistiocytosis CASE 07-5 CLINICAL LABORATORY SCIENCE PROGRAM UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES GRAND FORKS,
More informationFactors Affecting The Knowledge On Prevention Of Oral Diseases Among School Teachers Of Dharwad City, A Survey From India
Article ID: WMC001618 2046-1690 Factors Affecting The Knowledge On Prevention Of Oral Diseases Among School Teachers Of Dharwad City, A Survey From India Corresponding Author: Dr. Shodan M Raj, Assistant
More informationHemophagocytic Syndrome Associated with Herpes Virus 8 and Multicentric Castleman Diseases in a HIV-Negative Patient
JMID/ 2017; 7 (4):202-206 Journal of Microbiology and Infectious Diseases doi: 10.5799/jmid.369272 CASE REPORT Hemophagocytic Syndrome Associated with Herpes Virus 8 and Multicentric Castleman Diseases
More informationArticle ID: WMC00971 ISSN
Article ID: WMC00971 ISSN 2046-1690 Euthanasia Corresponding Author: Mr. Mohamed Najimudeen, Associate Professor, Obstetrics and Gynaecology, Melaka Manipal Medical College, Malaysia, Jalan Batu Hampar,
More informationImportance Of Sampling Sites For Postmortem Evaluation Of Ethanol
Article ID: WMC001584 2046-1690 Importance Of Sampling Sites For Postmortem Evaluation Of Ethanol Corresponding Author: Dr. Ozgur I Can, Assistant Professor, Dokuz Eylul University School of Medicine Department
More informationForm 2033 R3.0: Wiskott-Aldrich Syndrome Pre-HSCT Data
Key Fields Sequence Number: Date Received: - - CIBMTR Center Number: CIBMTR Recipient ID: Has this patient's data been previously reported to USIDNET? USIDNET ID: Today's Date: - - Date of HSCT for which
More informationStreptococcus (GAS) as Cause of Necrotizing Fasciitis Associated with Septic Shock and Multiorgan Dysfunction
Article ID: WMC003224 ISSN 2046-1690 Streptococcus (GAS) as Cause of Necrotizing Fasciitis Associated with Septic Shock and Multiorgan Dysfunction Corresponding Author: Dr. Klodiana Shkurti, Department
More informationThere are two main causes of a low platelet count
Thrombocytopenia Thrombocytopenia is a condition in which a person's blood has an unusually low level of platelets Platelets, also called thrombocytes, are found in a person's blood along with red blood
More informationSoliris (eculizumab) DRUG.00050
Market DC Soliris (eculizumab) DRUG.00050 Override(s) Prior Authorization Approval Duration 1 year Medications Soliris (eculizumab) APPROVAL CRITERIA Paroxysmal Nocturnal Hemoglobinuria I. Initiation of
More informationHematologic changes in systemic diseases. Chittima Sirijerachai
Hematologic changes in systemic diseases Chittima Sirijerachai Systemic diseases Infection Renal diseases Liver diseases Connective tissue diseases Malignancy Anemia of chronic disease (ACD) Chronic infections:
More information