MOOD VARIABILITY AND SLEEP DEPRIVATION EFFECT AS PREDICTORS OF THERAPEUTIC RESPONSE IN DEPRESSION
|
|
- Opal Wheeler
- 6 years ago
- Views:
Transcription
1 MOOD VARIABILITY AND SLEEP DEPRIVATION EFFECT AS PREDICTORS OF THERAPEUTIC RESPONSE IN DEPRESSION Gordijn, M.C.M., Beersma, D.G.M., Bouhuys, A.L., Van den Hoofdakker, R.H. Dept. of Biological Psychiatry, University Clinic, P.O. Box , 9700 RB Groningen, The Netherlands INTRODUCTION The variability of diurnal mood variations (DVs) in depressed patients correlates positively with the therapeutic effect of total sleep deprivation (TSD) (Gordijn et al., 1994). We proposed that high variability of DVs reflects a patient s vulnerability to external factors, which might explain the effects of TSD or other antidepressive treatments. A relationship between sleep deprivation response and therapeutic response to treatment with antidepressants has been demonstrated in two studies (Wirz- Justice et al., 1979; Fähndrich, 1983). Wirz-Justice et al. (1979) reported that of 34 sleep deprivation responders, 24 improved after subsequent tricyclic antidepressant treatment. Fähndrich (1983) stated that responders to sleep deprivation have a good chance of being successfully treated with clomipramine whereas non-responders to sleep deprivation can more likely be successfully treated with maprotiline. In the latter study also the presence of DVs during treatment predicted an antidepressant response. Purpose of the present study was to analyse the relationships between diurnal mood variability, the therapeutic effect of sleep deprivation and outcome after a 6-weeks period of antidepressive therapy. METHODS Our database consists of selfratings of mood on an adjective mood scale (AMS, Von Zerssen, 1986) at 9 a.m. and 10 p.m. during a 6 weeks period of antidepressive therapy. The ratings were done by 81 depressed in-patients (57 women and 24 men). So-called Hamilton ratings (HRSD 21-items, Hamilton, 1967) were present at the beginning (T1) and end of the treatment period (T2). Drug treatment consisted of antidepressants (n=79), predominantly clomipramine (n=62). The antidepressants were sometimes combined with neuroleptics (n=24) and/or lithium (n=23). One subject received neither antidepressants nor neuroleptics, nor lithium and one subject received lithium as monotherapy. Each patient was subjected to at least one total sleep deprivation within the first 14 days after T1. For each individual, we calculated (1) the average sleep deprivation effect over the total number of available sleep deprivation nights (range 1-4) within this period, (2) the average difference between mood on the day after sleep deprivation and mood on the day after recovery-sleep and (3) the average difference in mood on the day before a normal night of sleep and the day after. Additionally, we calculated (4) the average amplitude of the DVs and (5) the variability of the DVs (i.e. the standard deviation of the DVs) on the first 14 days after T1, excluding the day before and after TSD. 41
2 Correlations between the sleep deprivation effect, the effect of recovery sleep, diurnal mood variation and the variability in DV with the severity of depression (HRSD) at T2 were performed to analyse their relationships with outcome after 6 weeks. In the analysis the severity of depression (HRSD) at T1 was controlled for. Multiple regression analysis (stepwise) was performed with the variables that showed significant correlations in order to examine whether they predict therapy outcome independently. RESULTS On average, mood improved 3.7±0.9 (se) AMS points after TSD relative to the day before TSD (F(1,80)=17.16, p<0.001). After one night of recovery-sleep average mood worsened on average 1.3 ± 1.0 AMS points relative to the day after sleep deprivation (F(1,80)=1.72, n.s.), (figure 1a). The average difference between mood on the day before a normal night of sleep and the day after was 0.6 ±0.3 (figure 1b, n=76). Five patients were excluded because there were no days before and after normal sleep left after exclusion of the days before and after TSDs and recovery-sleep. Figure 1: a. The average selfratings of mood at 9:00 and 22:00 h before total sleep deprivation, after total sleep deprivation and after one night of recovery-sleep. Values were obtained during the first 14 days of treatment, (81 depressed patients, range of sleep deprivations per individual 1-4). b. The average selfratings of mood at 9:00 and 22:00 h on two consecutive days, within the first 14 days of treatment, with a normal night of sleep in between. Days prior to and following sleep deprivation, as well as days following recovery sleep were excluded, (76 depressed patients, range of two consecutive days per individual 1-5). 42
3 The average sleep deprivation effect is significantly different from the average mood difference between two days with a normal night of sleep in between (F(1,75)=8.67, p<0.005). The relapse in mood after recovery-sleep is not significantly different from the mood change over a night of normal sleep (F(1,75)=1.38, n.s.). The difference between mood on the day after recovery sleep and the day prior to sleep deprivation (2.4 AMS points) is even significantly different from the average change in mood ratings over three days with two normal sleep nights in between (0.2±0.5, n=60 due to missing days, F(1,59)=8.9, p<0.005). The average difference between the AMS rating in the morning and the AMS rating in the evening (the amplitude of the DV) was 2.1±0.6 (F(1,80)=14.62, p<0.001) and the standard deviation (variability of DV) was 5.5±0.6. Baseline severity of depression (HRSD at T1) was 25.4 ± 5.3 (sd). The HRSD at T2 was 19.1 ± 9.0. Partial correlations between the average DV-amplitude, the variability of DV, the TSD effect and the recovery-sleep effect in the first 14 days, with the HRSD rating at T2, controlled for the HRSD rating at T1, revealed significant correlations for variability of DV (r=-0.26, p<.05), TSD effect (r=-0.36, p<.001) and for the effect of recovery-sleep (r=.29, p<.01) but not for the average DV-amplitude (r=0.008, p=.94). Thus, a large variability in diurnal mood variations, a beneficial sleep deprivation effect and a small relapse after recovery-sleep in the first 14 days were correlated with a relatively low depression score after a 6 weeks period with antidepressive therapy. Multiple regression analysis was performed with HRSD at T1 forced into the equation as block 1 and variability of DV, sleep deprivation effect and recovery-sleep effect as block 2, with HRSD at T2 as the predicted variable. The results are presented in table 1. A high baseline severity of depression (HRSD T1) predicted a high severity of depression at T2. In other words, patients who were severely depressed at the start of the 6 weeks period had a high chance to be severely depressed after 6 weeks. In the second step, only the sleep deprivation effect contributed significantly to the equation: a beneficial sleep-deprivation response predicted low depression scores. Table 1: Prediction of depression outcome (HRSD T2) after 6 weeks, results of multiple regression analysis (stepwise). Predictor ß t p F(2,78) adjusted R 2 p Step 1 baseline HRSD (T1): Step 2 sleep deprivation effect: Variables not in the equation: variability of DV and recovery-sleep effect (p>0.1) 43
4 CONCLUSIONS The first conclusion from this study on sleep deprivation effects in a large group of depressed inpatients is that sleep deprivation has on average a significant mood improving effect. The sleep deprivation effect was significantly different from normal day to day mood changes. The relapse in mood after one night of recovery-sleep was not significant, and even more importantly, the average mood change over the recovery-night was not significantly different from the average change in mood over a normal night of sleep. Mood stayed improved on the day after recovery sleep compared to mood on the day prior to sleep deprivation and this was significantly different from the course of mood over three days with two normal sleep nights in between. This seems in contrast with the notion that the beneficial effect of sleep deprivation on mood is completely lost after one night of sleep. In the literature relapse rates in medicated patients who responded to sleep deprivation vary from 47 to 59% (review in Van den Hoofdakker, 1994). It is concluded that on average some beneficial effect of sleep deprivation on mood remains after recovery sleep. The question how long the sleep deprivation effect lasts and the issue of possible influences of the various drugs on the effects of sleep deprivation and recovery-sleep will be presented elsewhere (Gordijn et al. in prep). Significant relationships were found between variability of DV, sleep deprivation effect and recovery-sleep effect with improvement after 6 weeks of antidepressive therapy. The average DV-amplitude was not significantly correlated with treatment outcome after 6 weeks. The result that a high variability of DV, a beneficial effect of sleep deprivation and a small relapse of mood after recovery-sleep predict low depression ratings after 6 weeks of treatment is in line with our hypothesis that a high variability of DV might reflect a patients vulnerability to mood improving stimuli, such as sleep deprivation, but also to those of other antidepressive interventions. The results of the present study confirm the conclusions of the two previous studies on the predicting values of sleep deprivation and DV with respect to the response to antidepressive therapy (Wirz-Justice et al., 1979; Fähndrich, 1983). In those studies, however, the subjects were categorized as responders or non-responders to sleep deprivation and to the antidepressive treatment, while the large data set of the present study allowed a correlative analysis. In a previous study we could not find significant correlations between sleep deprivation effect on mood and therapy outcome (Bouhuys et al. subm.). This is probably due to the difference in group size between that study (25 subjects) and the present study (n=81, including those 25 subjects). We reported earlier that variability of DV was highly correlated with the effect of sleep deprivation (Gordijn et al., 1994). As was mentioned above, both variables are related to therapy outcome after 6 weeks. In the present report we studied whether these variables are independently related to depression outcome by means of a multiple regression analysis. The fact that only the sleep deprivation effect contributed significantly to therapy outcome and that variability of DV did not add significant- 44
5 ly to the explained variance suggests that both variables might be related to a common process. It is conceivable that both variability of DV and sleep-deprivation effect reflect a patients capacity to show mood changes. In summary, sleep deprivation in severely depressed inpatients might be a useful tool in antidepressive therapy. This is not only because the beneficial effects on mood might last longer than for just one day but also because a favourable TSD response predict a favourable outcome of antidepressive treatment. This study was supported by VWS grant REFERENCES Bouhuys A.L., Heeg G.P., Gordijn, M.C.M. and Beersma, D.G.M. The prediction of the 6-weeks outcome in depression from baseline activation: a study on variation in objective voice pitch, subjective energy and tension. (1998, subm). Fähndrich E (1983) Clinical and biological parameters as predictors for antidepressant drug responses in depressed patients. Pharmacopsychiat 16: Gordijn MCM, Beersma DGM, Bouhuys AL, Reinink E, and Van den Hoofdakker RH (1994) A longitudinal study of diurnal mood variation in depression; characteristics and significance. J Affect Disord 31: Gordijn, M.C.M., Beersma, D.G.M., Bouhuys A.L. and Van den Hoofdakker, R.H. Mood variability and sleep deprivation effect as predictors of therapeutic response in depression. (1998, in prep). Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6: Van den Hoofdakker RH (1994) Chronobiological theories of nonseasonal affective disorders and their implications for treatment. J Biol Rhythms 9: Von Zerssen D (1986) Clinical self-rating scales (CSRS) of the Munich Psychiatric Information System (PSYCHIS München). In Assessment of Depression, N Sartorius and TA Ban, eds, pp , Springer-Verlag, Berlin. Wirz-Justice A, Pühringer W, and Hole G (1979) Response to sleep deprivation as a predictor of therapeutic results with antidepressant drugs. Am J Psychiatr 136:
University of Groningen
University of Groningen Can winter depression be prevented by light treatment? Meesters, Ybe; Lambers, Petrus A.; Jansen, Jacob; Bouhuys, Antoinette; Beersma, Domien G.M.; Hoofdakker, Rutger H. van den
More informationUniversity of Groningen. An ethological approach of interpersonal theories of depression Geerts, Erwin Adrianus Henricus Maria
University of Groningen An ethological approach of interpersonal theories of depression Geerts, Erwin Adrianus Henricus Maria IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's
More informationUniversity of Groningen
University of Groningen Self-rated arousal concurrent with the antidepressant response to total sleep deprivation of patients with a major depressive disorder Burg, W. van den; Beersma, D.G.M.; Bouhuys,
More informationUniversity of Groningen
University of Groningen Extraocular Light Therapy in Winter Depression Koorengevel, Kathelijne M.; Gordijn, Margaretha; Beersma, Domien G.M.; Meesters, Ybe; den Boer, Johan A. ; Hoofdakker, Rutger H. van
More informationIn search of light therapy to optimize the internal clock, performance and sleep Geerdink, Moniek
University of Groningen In search of light therapy to optimize the internal clock, performance and sleep Geerdink, Moniek IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's
More informationThe winter recurrence of depressive episodes in patients
EEG and Subjective Sleepiness during Extended Wakefulness in Seasonal Affective Disorder: Circadian and Homeostatic Influences Christian Cajochen, Daniel P. Brunner, Kurt Kräuchi, Peter Graw, and Anna
More informationDiurnal Pattern of Reaction Time: Statistical analysis
Diurnal Pattern of Reaction Time: Statistical analysis Prepared by: Alison L. Gibbs, PhD, PStat Prepared for: Dr. Principal Investigator of Reaction Time Project January 11, 2015 Summary: This report gives
More informationGlasgow, 1055 Great Western Road, Glasgow G12 0XH, UK
Title and running title: Conscientiousness predicts diurnal preference Alexandra L. Hogben* 1 Jason Ellis* 2 Simon N. Archer 1 Malcolm von Schantz 1 * These authors contributed equally to this work 1 Surrey
More informationJournal of Affective Disorders
Journal of Affective Disorders 136 (2012) 72 80 Contents lists available at SciVerse ScienceDirect Journal of Affective Disorders journal homepage: www.elsevier.com/locate/jad Research Report The effects
More informationEffects of light exposure and sleep displacement on dim light melatonin onset Gordijn, Margaretha; Beersma, DGM; Korte, HJ; Van den Hoofdakker, RH
University of Groningen Effects of light exposure and sleep displacement on dim light melatonin onset Gordijn, Margaretha; Beersma, DGM; Korte, HJ; Van den Hoofdakker, RH Published in: Journal of Sleep
More informationDiurnal Mood Variation in Major Depressive Disorder
Emotion Copyright 2006 by the American Psychological Association 2006, Vol. 6, No. 3, 383 391 1528-3542/06/$12.00 DOI: 10.1037/1528-3542.6.3.383 Diurnal Mood Variation in Major Depressive Disorder Frenk
More informationPage 1 of 18 Volume 01 Page 1
Response to Vagus Nerve Stimulation (VNS) Therapy Treatment-Resistant Depression (TRD) Indication Not Approvable Letter from the United States Food and Drug Administration (FDA), Dated August 11, 2004
More informationFlupenthixol Decanoate (Fluanxol Depot) in the Treatment of Chronic Schizophrenic Patients
Flupenthixol Decanoate (Fluanxol Depot) in the Treatment of Chronic Schizophrenic Patients Abstract Pages with reference to book, From 286 To 289 Ijaz Haider ( Quaid-e-Azam Medical College and B.V. Hospital,
More informationWho s Not Sleepy at Night? Individual Factors Influencing Resistance to Drowsiness during Atypical Working Hours
Who s Not Sleepy at Night? Individual Factors Influencing Resistance to Drowsiness during Atypical Working Hours Halszka OGINSKA Department of Ergonomics, Jagiellonian University, Kraków, Poland Abstract:
More informationTreating alcoholrelated. depression. James Foulds Senior Lecturer National Addiction Centre Christchurch, NZ
Treating alcoholrelated depression James Foulds Senior Lecturer National Addiction Centre Christchurch, NZ Overview of talk Epidemiology and etiology of alcoholrelated comorbidity Alcohol-related depression
More informationTitle: The efficacy of fish oil supplements in the treatment of depression: food for thought
Title: The efficacy of fish oil supplements in the treatment of depression: food for thought Response to: Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major
More informationSeasonal Affective Disorder in Vermont
University of Vermont ScholarWorks @ UVM Family Medicine Clerkship Student Projects College of Medicine 2018 Seasonal Affective Disorder in Vermont Hannah Johnson Follow this and additional works at: https://scholarworks.uvm.edu/fmclerk
More informationMedication Management. Dr Ajith Weeraman MBBS, MD (Psychiatry), FRANZCP Consultant Psychiatrist Epworth Clinic Camberwell 14 th March 2015
Medication Management Dr Ajith Weeraman MBBS, MD (Psychiatry), FRANZCP Consultant Psychiatrist Epworth Clinic Camberwell 14 th March 2015 1 Medication Management Objectives: 1. Principles of psycho-pharmacology
More informationSetting The setting was primary and secondary care. The economic evaluation was conducted in France.
Cost-effectiveness of mirtazapine relative to fluoxetine in the treatment of moderate and severe depression in France Brown M C, van Loon J M, Guest J F Record Status This is a critical abstract of an
More informationThis brief animation illustrates the EEG patterns of the different stages of sleep, including NREM and REM sleep.
Brain wave frequency and amplitude This brief animation illustrates the EEG patterns of the different stages of sleep, including NREM and REM sleep. http://www.youtube.com/watch?v=u WYwMnMMEoU&feature=related
More informationLight treatment for sleep disorders: consensus report. IV. Sleep phase and duration disturbances.
J Biol Rhythms 1995 Jun;10(2):135-47 Related Articles, Books, LinkOut Light treatment for sleep disorders: consensus report. IV. Sleep phase and duration disturbances. Terman M, Lewy AJ, Dijk DJ, Boulos
More informationThe 30 th Annual Meeting Groningen 2018 Preliminary Program
Hanzeplein 1, 9713 GZ Groningen Netherlands The 30 th Annual Meeting Groningen 2018 Preliminary Program Thursday, June 21 st 8:45-12:30 8:45-9:00 9:00-9:45 Room 5161.0253, Bernoulliborg, Zernike Campus
More informationBehavioural and Cognitive Psychotherapy, 1998, 26, Cambridge University Press. Printed in the United Kingdom
Behavioural and Cognitive Psychotherapy, 1998, 26, 87 91 Cambridge University Press. Printed in the United Kingdom Brief Clinical Reports TRAIT ANXIETY AS A PREDICTOR OF BEHAVIOUR THERAPY OUTCOME IN SPIDER
More informationACOUSTIC AND PERCEPTUAL PROPERTIES OF ENGLISH FRICATIVES
ISCA Archive ACOUSTIC AND PERCEPTUAL PROPERTIES OF ENGLISH FRICATIVES Allard Jongman 1, Yue Wang 2, and Joan Sereno 1 1 Linguistics Department, University of Kansas, Lawrence, KS 66045 U.S.A. 2 Department
More informationStudy population Patients in the UK, with moderate and severe depression, and within the age range 18 to 93 years.
Economic impact of using mirtazapine compared to amitriptyline and fluoxetine in the treatment of moderate and severe depression in the UK Borghi J, Guest J F Record Status This is a critical abstract
More informationUse of Ambient Lighting in Creating a Healing Environment for an Inpatient Psychiatric Unit
Use of Ambient Lighting in Creating a Healing Environment for an Inpatient Psychiatric Unit Mekeesha McClure, MSN, ANP-BC Sheron Salyer, DNSc, RNC, CHRC, VHA CM VA Tennessee Valley Healthcare System VA
More informationChapter 4 Disturbed sleep as a risk factor for aggression in prisoners with a psychotic illness: a brief report
Disturbed sleep as a risk factor for aggression in prisoners with a psychotic illness: a brief report Jesse Meijers, Joke M. Harte & Frédérique V. Scherder Psychology, Crime & Law 2015, 21:10, doi: 10.1080/1068316X.2015.1077246
More informationMultistate Outcome Analysis of Treatment MOAT
Multistate Outcome Analysis of Treatment MOAT Charles L. Bowden, M.D. Presented with Fond Memories of an Outstanding Statistician and Investigative Scientist Andy Leon Design contributors to low generalizability
More informationSupplementary Methods
Supplementary Materials for Suicidal Behavior During Lithium and Valproate Medication: A Withinindividual Eight Year Prospective Study of 50,000 Patients With Bipolar Disorder Supplementary Methods We
More informationFeasibility and Efficacy of Bright Light Therapy in Depressed Adolescent Inpatients
Original Article Feasibility and Efficacy of Bright Light Therapy in Depressed Adolescent Inpatients First Open-Label, Single-Arm, Prospective Clinical Trial Inken Kirschbaum-Lesch 1, Stephanie Gest 1,
More informationSupplementary Material
Supplementary Material A detailed summary of participant information is shown in Table 2. Age, body mass index (BMI), and gender are described, as well as the QIDS score for depression and the Altman score
More informationS P O U S A L R ES E M B L A N C E I N PSYCHOPATHOLOGY: A C O M PA R I SO N O F PA R E N T S O F C H I LD R E N W I T H A N D WITHOUT PSYCHOPATHOLOGY
Aggregation of psychopathology in a clinical sample of children and their parents S P O U S A L R ES E M B L A N C E I N PSYCHOPATHOLOGY: A C O M PA R I SO N O F PA R E N T S O F C H I LD R E N W I T H
More informationNatural treatments for seasonal and non-seasonal depression: a review of literature and comparison of antidepressant responses
Scientific Journal of Review (2013) 2(1) ISSN 2322-2433 Contents lists available at Sjournals Journal homepage: www.sjournals.com Review article Natural treatments for seasonal and non-seasonal depression:
More informationDistribution of REM Latencies and Other Sleep Phenomena in Depression as Explained by a Single Ultradian Rhythm Disturbance
Sleep, 7(2):126-136 1984 Raven Press, New York Distribution of REM Latencies and Other Sleep Phenomena in Depression as Explained by a Single Ultradian Rhythm Disturbance 0. G. M. Beersma, S. Daan, and
More informationSuicide Risk and Melancholic Features of Major Depressive Disorder: A Diagnostic Imperative
Suicide Risk and Melancholic Features of Major Depressive Disorder: A Diagnostic Imperative Robert I. Simon, M.D.* Suicide risk is increased in patients with Major Depressive Disorder with Melancholic
More informationUniversity of Groningen. Children of bipolar parents Wals, Marjolein
University of Groningen Children of bipolar parents Wals, Marjolein IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document
More informationGuilt Suicidality. Depression Co-Occurs with Medical Illness The rate of major depression among those with medical illness is significant.
1-800-PSYCH If you are obsessive-compulsive, dial 1 repeatedly If you are paranoid-delusional, dial 2 and wait, your call is being traced If you are schizophrenic, a little voice will tell you what number
More informationFrequency of nocturnal symptoms in asthmatic children attending a hospital out-patient clinic
Eur Respir J, 1995, 8, 2076 2080 DOI: 10.1183/09031936.95.08122076 Printed in UK - all rights reserved Copyright ERS Journals Ltd 1995 European Respiratory Journal ISSN 0903-1936 Frequency of nocturnal
More informationThe Role of Activation in the Effect of Total Sleep Deprivation on Depressed Mood
The Role of Activation in the Effect of Total Sleep Deprivation on Depressed Mood L. E. Beutler University of California, Santa Barbara M. C. Cano University of Jaen E. Miró and G. Buela-Casal University
More informationChronobiology and Sleep. Prolonged Interval From Body Temperature Nadir to Sleep Offset in Patients With Delayed Sleep Phase Syndrome
Sleep, 19(1):36-40 1996 American Sleep Disorders Association and Sleep Research Society Chronobiology and Sleep Prolonged Interval From Body Temperature Nadir to Sleep Offset in Patients With Delayed Sleep
More informationLight therapy for non-seasonal depression (Review)
Tuunainen A, Kripke DF, Endo T This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2009, Issue 3 http://www.thecochranelibrary.com
More informationA Forced Desynchrony Study of Circadian Pacemaker Characteristics in Seasonal Affective Disorder
University of Groningen A forced desynchrony study of circadian pacemaker characteristics in seasonal affective disorder Koorengevel, Kathelijne M.; Beersma, Domien G.M.; den Boer, Johan; Hoofdakker, Rutger
More informationOur Experience with Antidepressant Treatment in the Obese and Type 2 Diabetics
Prague Medical Report / Vol. 106 (2005) No. 3, p. 291 296 291) Our Experience with Antidepressant Treatment in the Obese and Type 2 Diabetics Third Medical Department of the First Faculty of Medicine,
More informationUniversity of Groningen. ADHD & Addiction van Emmerik-van Oortmerssen, Katelijne
University of Groningen ADHD & Addiction van Emmerik-van Oortmerssen, Katelijne IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please
More informationSupplementary Online Content
Supplementary Online Content Lam RW, Levitt AJ, Levitan RD, et al. Efficacy of bright light treatment, fluoxetine, and the combination in patients with nonseasonal major depressive disorder: a randomized
More informationBipolar Disorder Clinical Practice Guideline Summary for Primary Care
Bipolar Disorder Clinical Practice Guideline Summary for Primary Care DIAGNOSIS AND CLINICAL ASSESSMENT Bipolar Disorder is categorized by extreme mood cycling; manifested by periods of euphoria, grandiosity,
More informationMixing and Matching: Layering Medications as Family Physicians
Mixing and Matching: Layering Medications as Family Physicians Family Medicine Forum Vancouver, B.C. November 9-12, 2016. Jon Davine, CCFP, FRCP(C) McMaster University Objectives Discuss different examples
More informationUniversity of Groningen
University of Groningen Prophylactic treatment of seasonal affective disorder (SAD) by using light visors Meesters, Ybe; Beersma, DGM; Bouhuys, Antoinette; van den Hoofdakker, RH Published in: Biological
More informationModeling the dynamics of patients with bipolar disorder. Nicole Kennerly NSF-NIH BBSI 2006 Mentor: Shlomo Ta asan
Modeling the dynamics of patients with bipolar disorder Nicole Kennerly NSF-NIH BBSI 2006 Mentor: Shlomo Ta asan Bipolar disorder, a.k.a. manic depression Characterized by abnormal brain functioning that
More informationNo impact of physical activity on the period of the circadian pacemaker in humans Beersma, DGM; Hiddinga, AE
University of Groningen No impact of physical activity on the period of the circadian pacemaker in humans Beersma, DGM; Hiddinga, AE Published in: Chronobiology International DOI: 10.3109/07420529808998669
More informationChronotherapeutics (light and wake therapy) in affective disorders*
Psychological Medicine, 2005, 35, 939 944. f 2005 Cambridge University Press doi:10.1017/s003329170500437x Printed in the United Kingdom EDITORIAL Chronotherapeutics (light and wake therapy) in affective
More informationUniversity of Groningen
University of Groningen A 12-month follow-up study of treating overweight schizophrenic patients with aripiprazole Schorr, S. G.; Slooff, C. J.; Postema, R.; Van Oven, W.; Schilthuis, M.; Bruggeman, Richard;
More informationPOLYPHARMACY : FOR AND AGAINST NZMA GP CONFERENCE 2012 PSYCHOPHARMACOLOGY SERIES. Guna Kanniah Waikato Hospital
POLYPHARMACY : FOR AND AGAINST NZMA GP CONFERENCE 212 PSYCHOPHARMACOLOGY SERIES Guna Kanniah Waikato Hospital POLYPHARMACY FIVE REASONS FOR POLYPHARMACY 1. To treat a concomitant disorder 2. To treat an
More informationNavigating Student Mental Health Issues
Navigating Student Mental Health Issues Brian D. Saunders, MD, FACS Director of Undergraduate Surgical Education Penn State College of Medicine Trouble Shooting Your Clerkship 103 April 22, 2013 Orlando,
More informationNIH Public Access Author Manuscript Psychiatry Clin Neurosci. Author manuscript; available in PMC 2010 November 1.
NIH Public Access Author Manuscript Published in final edited form as: Psychiatry Clin Neurosci. 2003 October ; 57(5): 542 544. An Open Pilot Study of Gabapentin vs. Trazodone to Treat Insomnia in Alcoholic
More informationThe Safety and Efficacy of Ondansetron in the Treatment of Obsessive Compulsive Disorder
Duquesne University Duquesne Scholarship Collection Graduate Student Research Symposium The 4th Annual Graduate Student Research Symposium September 19, 2017 The Safety and Efficacy of Ondansetron in the
More informationMORNINGNESS-EVENINGNES05S QUESTIONNAIRE Self-Assessment Version (MEQ-SA) 1. Name: Date:
MORNINGNESS-EVENINGNES05S QUESTIONNAIRE Self-Assessment Version (MEQ-SA) 1 Name: Date: For each question, please select the answer that best describes you by circling the point value that best indicates
More informationSuitable dose and duration of fluvoxamine administration to treat depression
PCN Psychiatric and Clinical Neurosciences 1323-13162003 Blackwell Science Pty Ltd 572April 2003 1098 Dose and duration of fluvoxamine S. Morishita and S. Arita 10.1046/j.1323-1316.2002.01098.x Original
More informationDo self-rated and objective measures of cognitive impairment correlate in patients with work-related stress? preliminary results and perspectives
Bispebjerg Hospital, University of Copenhagen Dept. Occupational and Environmental Medicine Do self-rated and objective measures of cognitive impairment correlate in patients with work-related stress?
More informationAccess to the published version may require journal subscription. Published with permission from: Springer
This is an author produced version of a paper published in Quality of Life Research. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination.
More informationRandomized controlled trial of physical activity counseling as an aid to smoking cessation: 12 month follow-up
Addictive Behaviors 32 (2007) 3060 3064 Short communication Randomized controlled trial of physical activity counseling as an aid to smoking cessation: 12 month follow-up Michael Ussher a,, Robert West
More informationSleep and circadian rhythms in mood disorders
Acta Psychiatr Scand 2007: 115 (Suppl. 433): 104 115 All rights reserved Copyright Ó Blackwell Munksgaard 2007 ACTA PSYCHIATRICA SCANDINAVICA Sleep and circadian rhythms in mood disorders Armitage R. Sleep
More informationAcute pharmacodynamic tolerance to the of cigarette smoking. subjective effects. Psychopharmacology. Psychopharmacology (1994) 116:93-97
Psychopharmacology (1994) 116:93-97 Psychopharmacology Springer-Verlag 1994 Acute pharmacodynamic tolerance to the of cigarette smoking subjective effects A.C. Parrott Department of Psychology, University
More informationClinical Study Depressive Symptom Clusters and Neuropsychological Performance in Mild Alzheimer s and Cognitively Normal Elderly
Hindawi Publishing Corporation Depression Research and Treatment Volume 2011, Article ID 396958, 6 pages doi:10.1155/2011/396958 Clinical Study Depressive Symptom Clusters and Neuropsychological Performance
More informationMethods for Computing Missing Item Response in Psychometric Scale Construction
American Journal of Biostatistics Original Research Paper Methods for Computing Missing Item Response in Psychometric Scale Construction Ohidul Islam Siddiqui Institute of Statistical Research and Training
More informationUNC CFAR Social and Behavioral Science Research Core SABI Database
INSTRUMENT TITLE: Hamilton Depression Rating Scale (HDRS) SOURCE ARTICLE: Hamilton, M. (1960). A Rating Scale for Depression. J Neurol Neurosurg Psychiatry, 23: 56-62. RESPONSE OPTIONS: The variables are
More informationBackground. 2 5/30/2017 Company Confidential 2015 Eli Lilly and Company
May 2017 Estimating the effects of patient-reported outcome (PRO) diarrhea and pain measures on PRO fatigue: data analysis from a phase 2 study of abemaciclib monotherapy, a CDK4 and CDK6 inhibitor, in
More informationEarly response as predictor of final remission in elderly depressed patients
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Int J Geriatr Psychiatry (2009) Published online in Wiley InterScience (www.interscience.wiley.com).2261 Early response as predictor of final remission in
More informationAdvancements in the Assessment of Medication Adherence: A Panel Discussion and Case Study. Finding Clarity in the Midst of Uncertainty
Advancements in the Assessment of Medication Adherence: A Panel Discussion and Case Study Finding Clarity in the Midst of Uncertainty Agenda Medication adherence in serious mental illness Consequences
More informationChapter 4. The natural history of depression in old age
The natural history of depression in old age StekML,Vinkers DJ,Gussekloo J,van der Mast RC,Beekman ATF,W estendorp RGJ. The natural history of depression in the oldest old.a population-based prospective
More informationDepression often comorbid with alcohol dependence 1.6x higher rate of alcohol dependence in depressed subjects Depressed subjects with alcohol
Lindsay French PGY3 Depression often comorbid with alcohol dependence 1.6x higher rate of alcohol dependence in depressed subjects Depressed subjects with alcohol dependence have complicated course of
More informationExploring daytime sleepiness during migraine
Exploring daytime sleepiness during migraine J.H.M. TULEN 1, D.L. STRONKS 1,2, L. PEPPLINKHUIZEN 1, J. PASSCHIER 2 DEPARTMENTS OF PSYCHIATRY 1 AND MEDICAL PSYCHOLOGY & PSYCHOTHERAPY 2, UNIVERSITY HOSPITAL
More informationACCELERATING RESPONSE IN GERIATRIC DEPRESSION: A PILOT STUDY COMBINING SLEEP DEPRIVATION AND PAROXETINE
DEPRESSION AND ANXIETY 6:113 118 (1997) ACCELERATING RESPONSE IN GERIATRIC DEPRESSION: A PILOT STUDY COMBINING SLEEP DEPRIVATION AND PAROXETINE Gregory M. Bump, M.S., 1 Charles F. Reynolds III, M.D., 1
More informationPredicting Complaints of Impaired Cognitive Functioning in Patients with Chronic Pain
392 Journal of Pain and Symptom Management Vol. 21 No. 5 May 2001 Original Article Predicting Complaints of Impaired Cognitive Functioning in Patients with Chronic Pain Lance M. McCracken, PhD and Grant
More informationOutline. Understanding Placebo Response in Psychiatry: The Good, The Bad, and The Ugly. Definitions
Outline Understanding Placebo Response in Psychiatry: The Good, The Bad, and The Ugly Michael E. Thase, MD Professor of Psychiatry Perelman School of Medicine University of Pennsylvania and Philadelphia
More informationCONTEXT OF THE FUNDAMENTAL KNOWLEDGE ABOUT DIURNAL RHYTHMS WITH MENTAL HEALTH OF ADOLESCENTS
CONTEXT OF THE FUNDAMENTAL KNOWLEDGE ABOUT DIURNAL RHYTHMS WITH MENTAL HEALTH OF ADOLESCENTS Aska KONDO, Hitomi TAKEUCHI, Tetsuo HARADA Abstract: The objective of the study was to assess which of three
More informationTHE ROLE OF ACTIVITIES OF DAILY LIVING IN THE MCI SYNDROME
PERNECZKY 15/06/06 14:35 Page 1 THE ROLE OF ACTIVITIES OF DAILY LIVING IN THE MCI SYNDROME R. PERNECZKY, A. KURZ Department of Psychiatry and Psychotherapy, Technical University of Munich, Germany. Correspondence
More informationIn the last few years, evidence for the efficacy of psychotherapy
Article Relapse Prevention in With Bipolar Disorder: Outcome After 2 Years Dominic H. Lam, Ph.D. Peter Hayward, Ph.D. Edward R. Watkins, Ph.D. Kim Wright, B.A. Pak Sham, Ph.D. Objective: In a previous
More informationClass 7 Everything is Related
Class 7 Everything is Related Correlational Designs l 1 Topics Types of Correlational Designs Understanding Correlation Reporting Correlational Statistics Quantitative Designs l 2 Types of Correlational
More informationBest Practices in Prescribing Benzodiazepines. Michael Carlisle, DO Medical Director University Hospitals Geauga Medical Center
Best Practices in Prescribing Benzodiazepines Michael Carlisle, DO Medical Director University Hospitals Geauga Medical Center Objectives To review current practice guidelines in benzodiazepine prescribing
More informationAndrew Tilley, Frank Donohoe, and Sharon Hensby. Department of Psychology, University of Queensland, Queensland, Australia
Sleep 1(6):6-65, Raven Press, Ltd., New York 1987 Association of Professional Sleep Societies Homeostatic Changes in Slow Wave Sleep during Sleep Following Nocturnal Sleep and Partial Slow Wave Sleep during
More informationORIGINAL ARTICLE. A Controlled Trial of Timed Bright Light and Negative Air Ionization for Treatment of Winter Depression
ORIGINAL ARTICLE A Controlled Trial of Timed Bright Light and Negative Air Ionization for Treatment of Winter Depression Michael Terman, PhD; Jiuan Su Terman, PhD; Donald C. Ross, PhD Background: Artificial
More informationTHE SLEEP DIAGNOSIS LIST (SDL): A QUESTIONNAIRE FOR SCREENING GENERAL SLEEP DISORDERS
THE SLEEP DIAGNOSIS LIST (SDL): A QUESTIONNAIRE FOR SCREENING GENERAL SLEEP DISORDERS Sweere Y 1, Kerkhof GA 2, De Weerd AW 1, Kamphuisen HAC 1, Kemp B 1 & Schimsheimer RJ 1 1 Centre for Sleep and Wake
More informationREPEATED MEASURES DESIGNS
Repeated Measures Designs The SAGE Encyclopedia of Educational Research, Measurement and Evaluation Markus Brauer (University of Wisconsin-Madison) Target word count: 1000 - Actual word count: 1071 REPEATED
More informationRobert C. Whitaker, MD, MPH Professor of Epidemiology, Biostatistics and Pediatrics Temple University Philadelphia, PA
37 th Annual Meeting Society of Behavioral Medicine The Impact of School Start Time Change on Adolescents Sleep, Health, Safety, and School Functioning Robert C. Whitaker, MD, MPH Professor of Epidemiology,
More informationThe Mood-regulating Function of Sleep
KRAMER/ROTH Mood-regulating Function 563 an increase in the proportion of I ;;?: 2 sec. In Parkinson's disease, the proportions of the three types of intervals were decreased. References 40 DE LEE, C.:
More informationTrial No.: RIS-USA-102 Clinical phase: III
SYNOPSIS Trial identification and protocol summary Company: Johnson & Johnson Pharmaceutical Research and Development, a division of Janssen Pharmaceutica, N.V. Finished product: Risperdal Active ingredient:
More informationMaternal Depression: Prevalence, Implications, Diagnosis, and Current Treatment Options
Maternal Depression: Prevalence, Implications, Diagnosis, and Current Treatment Options Sarah E. (Betsy) Bledsoe-Mansori PhD, MPhil, MSW Assistant Professor Cathy Nguyen UNC School of Social Work Presented
More informationCHAIR SUMMIT 7TH ANNUAL #CHAIR2014. Master Class for Neuroscience Professional Development. September 11 13, Westin Tampa Harbour Island
#CHAIR2014 7TH ANNUAL CHAIR SUMMIT Master Class for Neuroscience Professional Development September 11 13, 2014 Westin Tampa Harbour Island Sponsored by #CHAIR2014 Bipolar Depression: Putting the End Goal
More informationDepressive Disorder in Children and Adolescents: Dysthymic Disorder and the Use of Self-Rating Scales in Assessment
Depressive Disorder in Children and Adolescents: Dysthymic Disorder and the Use of Self-Rating Scales in Assessment Stuart Fine, MB, FRCP (C), Marlene Moretti, MA, Glenn Haley, MA, Simon Fraser University.
More informationClinical Guideline for the Management of Bipolar Disorder in Adults
Clinical Guideline for the Management of Bipolar Disorder in Adults Goal: To improve the quality of life of adults with bipolar disorder Identification and Treatment of Bipolar Disorder Criteria for Diagnosis:
More informationATTENTION DEFICIT HYPERACTIVITY DISORDER COMORBIDITIES 23/02/2011. Oppositional Defiant Disorder
ATTENTION DEFICIT HYPERACTIVITY DISORDER COMORBIDITIES The comorbidity of ADHD with other disorders is between 60% and 80% The most commonly comorbid disorder that occur alongside ADHD are: Oppositional
More informationMEDICAL POLICY SUBJECT: PHOTOTHERAPY FOR THE TREATMENT OF SEASONAL AFFECTIVE DISORDER. POLICY NUMBER: CATEGORY: Behavioral Health
MEDICAL POLICY SUBJECT: PHOTOTHERAPY FOR THE ARCHIVED: 09/16/04-12/07/06 PAGE: 1 OF: 5 If a product excludes coverage for a service, it is not covered, and medical policy criteria do not apply. If a commercial
More informationINTERQUAL BEHAVIORAL HEALTH CRITERIA GERIATRIC PSYCHIATRY REVIEW PROCESS
INTERQUAL BEHAVIORAL HEALTH CRITERIA GERIATRIC PSYCHIATRY REVIEW PROCESS RP-1 RP-2 AGE PARAMETERS Geriatric Psychiatry Behavioral Health Criteria are for the review of patients who are ages 65 and older.
More informationPrevalence of anxiety and depressive symptoms in men with erectile dysfunction
Prevalence of anxiety and depressive symptoms in men with erectile dysfunction K Pankhurst, MB ChB G Joubert, BA, MSc P J Pretorius, MB ChB, MMed (Psych) Departments of Psychiatry and Biostatistics, University
More informationMETHODS RESULTS. Supported by funding from Ortho-McNeil Janssen Scientific Affairs, LLC
PREDICTORS OF MEDICATION ADHERENCE AMONG PATIENTS WITH SCHIZOPHRENIC DISORDERS TREATED WITH TYPICAL AND ATYPICAL ANTIPSYCHOTICS IN A LARGE STATE MEDICAID PROGRAM S.P. Lee 1 ; K. Lang 2 ; J. Jackel 2 ;
More informationUniversity of Groningen
University of Groningen Are effects of depression management training for General Practitioners on patient outcomes mediated by improvements in the process of care? van Os, TWDP; van den Brink, Robertus;
More informationThe Use of Bright Light in the Treatment of Insomnia
Chapter e39 The Use of Bright Light in the Treatment of Insomnia Leon Lack and Helen Wright Department of Psychology, Flinders University, Adelaide, South Australia PROTOCOL NAME The use of bright light
More informationClinical Study Seasonality and Sleep: A Clinical Study on Euthymic Mood Disorder Patients
Depression Research and Treatment Volume 2012, Article ID 978962, 6 pages doi:10.1155/2012/978962 Clinical Study Seasonality and Sleep: A Clinical Study on Euthymic Mood Disorder Patients Chiara Brambilla,
More information