STEREOTACTIC RADIOTHERAPY FOR
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1 STEREOTACTIC RADIOTHERAPY FOR MENINGIOMA PATIENT INFORMATION LEAFLET
2 STEREOTACTIC RADIOTHERAPY FOR MENINGIOMA You have recently been diagnosed with a meningioma. This leaflet will explain what these are and how they can be treated. WHAT IS A MENINGIOMA? A meningioma is a lesion that grows from the covering over the brain (meninges). They are very common and are often found without any symptoms on brain scans. Most meningiomas (90%) are benign (grade 1). This means they will not spread, but they can cause problems if they grow and start to press on the brain and other structures, such as nerves. Exactly how they present depends on where in the head they are. For example, some patients present with seizures (fits), others headache and others because they press on the nerves supplying the muscles of the face or eyes. HOW ARE MENINGIOMA TREATED? Not all meningioma need treating. Many grow very slowly and will never need treatment. When you see a specialist in meningioma, they will look not only at the size of your meningioma and how fast it is growing, but also your general fitness However, the options include: Watchful waiting: This is the management option used for many patients, particularly at the beginning. We will recommend you have an MRI scan every 6 to 24months to look at the speed of growth. If the lesion is hardly growing (<2mm per year) we may recommend we just keep scanning every couple of years. Or, if you have significant medical problems which means the meningioma is unlikely to cause you problems in your life expectancy, then we may decide that routine scans are not going to help, and discharge you back to your GP for follow up. Surgical resection: The surgeon tries to remove the meningioma completely. This is not always possible because the meningioma is stuck onto a blood vessel or nerves. The pros and cons of surgery will be discussed in detail with you by your surgeon. Stereotactic radiotherapy (SRT): this uses very focused X-ray radiation beams (the same sort used to treat cancer).they work by damaging the cells that are growing (dividing). As only a few cells in benign lesions are dividing it takes time (years) for the meningioma to shrink. It is therefore best thought of as a treatment to stop it getting bigger. Page 2
3 The treatment can be given in two ways: - Single treatment SRT (also called radiosurgery or SRS) can be used for very small lesions but have a higher chance of damage to local tissues. - Fractionated SRT: most patients with meningioma are treated with a course of daily treatments of radiotherapy. This schedule is chosen to reduce the risk of side effects. The neuro-surgeons, neuro-radiologists, neuro-oncologist (who delivers the SRT/SRS), will discuss the best way to treat your meningioma at a multi-disciplinary meeting. We will then discuss these options with you in the clinic. WHAT DOES THE PLANNING OF THE SRT INVOLVE? Preparing for your treatment involves a number of steps. You will need more than one appointment for this planning process. First you have to have a special mask made (see picture). You will need to wear this during the planning and delivery of the treatment to keep your head perfectly still. HOW IS THE MASK MADE? The mask is made from three pieces of plastic sheeting heated in warm water to make them flexible. It takes about an hour to make your mask. The back part is made by taking an impression of the back of your head with the warm plastic. We then wait for it to cool down and become rigid. This takes about 15 minutes. The straps on the front are made in the same way and again left to cool for another 15 minutes. Finally, the front part is made. Ideally this should be left for 30 minutes so it does not shrink once it is removed. The mask has to be tight to do its job, but it should not be uncomfortable. There are small holes in the plastic and you will be able to breathe normally. Though you will probably want to close your eyes for the final stage you can open them in the mask and see out. You might want to bring a music CD with you for this appointment to help you relax. Page 3
4 CT SCANNER MRI SCAN You will then have a CT scan wearing the mask. This involves putting the mask on and going through a scanner shaped like a large doughnut ring. It is painless and takes about 15minutes. This gives us the shape of your head for the planning calculations. Sometimes we may give an iodine contrast injection. You should already have had an MRI scan performed. This scan is also used to help us define where the SRT treatment needs to be given. It is important that we have all both sets of images (planning CT scan and MRI scan) to decide exactly where we need to target the SRT treatment PRODUCING YOUR TREATMENT PLAN Over the next few weeks the SRT team will design your treatment. The CT and MRI images are fused in a computer system. The neuro-radiologists and neuro-oncologists identify the meningioma that we need to target. They add a small margin to this. They will also outline any structures that can be sensitive to radiosurgery (eye nerves, brainstem). The physicists then select the best way to treat your meningioma. Page 4
5 The system we have in Edinburgh (Brainlab / Novalis Tx) allows us to treat either with beams that move around your head (arcs) or static (fixed) beams. We will select the one which shapes the area receiving the highest doses as close as possible to the shape of your meningioma. Once the plan is ready it will be reviewed by the neuro-oncologist who will then prescribe the treatment. The treatment data is then transferred to the radiotherapy machine (Linear Accelerator). WHAT HAPPENS ON THE DAY OF TREATMENT? If the SRT is given in a single treatment it can sometimes cause localised swelling and we use the steroids to reduce the risk of this. If you are having single fraction treatment the Stereotactic radiographer will arrange a prescription for you. Patients having the treatment over several weeks should not need this. THE TREATMENT When you come for your treatment you should go to the stereotactic radiotherapy machine (called LA7). The treatment radiographers will ask you to lie on the treatment couch. They will put on your mask. The radiographers will then place a frame over your mask. This has special balls which are used to realign you into exactly the same position as you were in when we performed the CT scan. The treatment couch will move a few millimetres. Once the radiographers are happy you are in the correct position they will leave the room and the treatment starts. It can be controlled completely from outside the room but the radiographers watch you on a camera wave your hand if you have a problem. If arcs are being used the machine will slowly move around your head. If static beams are being used it will stay put for about 60 seconds then move. The machine buzzes but you should not feel anything. Some patients occasionally smell ozone (smells like the sea). The treatment should take about 20 minutes in total. If you are having treatments they will take place daily (Monday to Friday). Each treatment is the same. Page 5
6 If you have had a single fraction SRS treatment you should not drive for one month (this is DVLA guidance). Otherwise, so long as you do not have seizures or other impairment that may affect your ability, you are allowed to drive WHAT HAPPENS AFTER THE TREATMENT? Immediately and up to one month: You can go home afterwards. Some patients feel a bit tired. It is probably a good idea to take it easy during your treatment and for a few weeks after. Some patients get a bit of a headache. If this does not settle with simple pain killers (e.g. paracetamol) please contact us (see details below). Very occasionally patients need steroids because the treatment causes swelling if you get worsening symptoms, contact us (see below). This is very unusual. One to 12 months We will see you in the clinic 4-8 weeks after your treatment. This is just to check how you got on and to answer any questions. We will then arrange an MRI for a year later. If you get any problems in that year please phone for advice. 12months and beyond We like to continue to see you every year, with a MRI scan, for at least the first five years. After this whether or not we continue scanning depends on your fitness. WHAT ARE THE SIDE EFFECTS OF THE TREATMENT? The side effects depend on the exact location of the meningioma During the course of treatment: occasionally patients feel a little sick or develop a headache. If this happens we will give you some anti-sickness tablets or steroids. You may lose some of your hair. This usually starts about 3 weeks into the treatment. 1to 12 months: most patients feel a little tired for the first month. Very occasionally sometime during the first year patients develop worsening Page 6
7 symptoms because of swelling. Contact us if this happens and we will give you steroid. One year to ten years: Sometimes SRT can damage the local tissues. Your neurooncologist will explain what could happen for your particular meningioma. We do everything we can do reduce this risk (using SRT to reduce the area in the high dose region and treating over several weeks) but sometimes complications can occur, possibly many years after the radiotherapy. There is also a small risk of a radiation-induced cancer. This is very rare so it is difficult to quote exact odds, but you need to be aware of the possibility. If a cancer develops it is usually more than 10 years after the treatment. WILL THE SRT WORK? Radiotherapy has been used to treat meningioma, but as with all medical treatments it does not work in everyone one. Around 80-90% of benign lesions are controlled by radiotherapy. If SRT doesn t work then it may be possible to operate, but it is more difficult. WHO DO YOU CONTACT IF THERE IS A PROBLEM? During the planning stage / prior to treatment contact the stereotactic radiographer. The radiographer can also answer questions about the treatment and explain in more details the treatment process. After the treatment contact Dr Erridge and Dr People s secretary (Mon-Fri ). If however it is a problem that cannot wait, then contact the on-call Oncology Specialist Registrar via the WGH switchboard OTHER SOURCES OF INFORMATION Scottish Adult Neuro-Oncology Network Website this is a clinical network of all professionals working in the brain tumour field in Scotland. There are links to some more pictures of the Novalis Tx with Dr Erridge as the model! Page 7
8 THE SRS/SRT TEAM Radiation Oncologists (Clinical Oncologists) doctors trained in the use of therapeutic X- rays Dr Sara C Erridge Dr Sharon Peoples Telephone: Secretary Therapy Radiographers trained in the delivery of therapeutic X-rays Joanna Henderson John Burton Telephone (LA7) SRSRad@nhslothian.scot.nhs.uk Medical Physicists trained in the planning and quality assurance of therapeutic X-rays Linda Carruthers Barry O Connell Neuro-Radiologists doctors trained in the imaging of brain lesions Dr Rod Gibson Dr David Summers Dr Susan Kealey Neurologist doctor trained in the medicine of brain and nerve disorders Dr Robin Grant Neuro-surgeon doctor trained in brain and spine surgery Professor Ian Whittle Mr Michael Fitzpatrick Mr Ioannis Fouyas Miss Lynn Myles Mr Jerard Ross Mr Patrick Statham SRS_meningioma_PIL_V1.1 Page 8
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