The Current Champion: Angiogenesis inhibitors
|
|
- Georgina Reed
- 6 years ago
- Views:
Transcription
1 The Current Champion: Angiogenesis inhibitors Baek-Yeol RYOO University of Ulsan College of Medicine ASAN Medical Center Dept. of Oncology Seoul, Korea
2 Survival probability Sorafenib: Overall Survival SHARP Asia-Pacific 1.00 Sorafenib (n=299) = 10.7 months Placebo (n=303) = 7.9 months HR = 0.69 (95% CI: ) p< Time from randomisation (months) - approved by FDA (Dec. 2007), EMEA (Oct. 2007) and KFDA (Mar. 2008) Llovet et al. N Engl J Med 2008 Cheng et al. Lancet Oncol 2009
3 Sorafenib: Targets Tumor Cell Proliferation and Angiogenesis Wilhelm et al. Mol Cancer Ther 2008
4 Sorafenib in the Tx of HCC Sorafenib is the first systemic therapy to significantly prolong survival in HCC patients. Sorafenib established a proof of concept for the use of a multi-kinase inhibitor strategy for the treatment of HCC. Sorafenib is the new reference standard for systemic therapy for HCC patients.
5 Systemic Therapy for HCC : 1 drug : 4 drugs (3 TKIs, 1 ICI)
6 Clinical Trials of 1st-line Therapy for HCC Trial Drug Targets Design n OS (mo) HR P SHARP Asia-Pacific SUN Sorafenib vs placebo Sorafenib vs placebo Sunitinib vs sorafenib Raf-1, VEGFR, PDGFR Raf-1, VEGFR, PDGFR c-kit, VEGFR, PDGFR Superiority DB 299 vs vs <0.001 Superiority DB 150 vs vs Superiority OL 530 vs vs LIGHT Linifanib vs sorafenib VEGFR, PDGFR Non-inferiority OL 514 vs vs NS BRISK-FL Brivanib vs sorafenib FGFR, VEGFR Non-inferiority DB 577 vs vs Nintedanib SEARCH CALGB REFLECT Nintetanib vs sorafenib Erlotinib+sorafenib vs sorafenib Doxorubicin+sorafenib vs sorafenib Lenvatinib vs sorafenib VEGFR, PDGFR, FGFR R-PII (PE: TTP) OL 63 vs vs NS EGFR Superiority DB 362 vs vs cytotoxic agent Superiority OL 180 vs vs VEGFR, FGFR, PDGFR *PE, Primary endpoint; DB, double-blinded; OL, open-label Non-inferiority OL 478 vs vs Non-inferior
7 Clinical Trials of 2nd-line Therapy for HCC Trial Drug Targets Design n OS (mo) HR P Axitinib Axitinib vs placebo VEGFR, PDGFR R-PII (PE: OS) 134 vs vs REACH Ramucirumab vs placebo VEGFR-2 (mab) Superiority 283 vs vs BRISK-PS Brivanib vs placebo FGFR, VEGFR Superiority 263 vs vs EVOLVE-1 Everolimus vs placebo mtor Superiority 362 vs vs ADI-PEG20 ADI-PEG20 vs placebo arginine auxotrophy Superiority 424 vs vs METIV-HCC Tivantinib vs placebo c-met (high) Superiority 226 vs vs JET-HCC Tivantinib vs placebo c-met (high) Superiority 134 vs vs REACH-2 Ramucirumab vs placebo VEGFR-2 (mab) Superiority Ongoing (AFP 400 ng/ml) RESORCE Regorafenib vs placebo VEGFR, PDGFR, Raf-1 Superiority 379 vs vs < CELESTIAL Cabozantinib vs placebo VEGFR, c-met Superiority 470 vs vs Checkmate 040 Nivolumab PD-1 (mab) Ph II *PE, Primary endpoint
8 Inhibits Regorafenib - VEGFR-1-3, PDGFR-β, Raf-1, c-kit, RET IC 50 (nm) Target Sorafenib Lenvatinib Regorafenib VEGFR VEGFR VEGFR PDGFR PDGFR-β c-kit 68-7 FGFR Flt c-raf Wilhelm et al. Cancer Res 2004 Selleckchem.com
9 RESORCE Trial RP III (2:1), 2nd-line, Regorafenib vs. Placebo Trial Design Bruix et al. Lancet 2017
10 Regorafenib Bruix et al. Lancet 2017
11 Regorafenib Bruix et al. Lancet 2017
12 Regorafenib Bruix et al. Lancet 2017
13 Regorafenib Bruix et al. Lancet 2017
14 Regorafenib Bruix et al. Lancet 2017
15 Regorafenib Finn et al. ASCO GI 2017
16 Regorafenib Is the First Treatment That Demonstrated Prolonged OS in Second-line Setting for HCC Patients Regorafenib demonstrated a statistically significant and clinically meaningful improvement in OS for patients with HCC who progressed on prior sorafenib Regorafenib significantly improved PFS Patients treated with regorafenib had significantly better ORR and DCR AEs were manageable and consistent with the regorafenib safety profile Bruix et al. Lancet 2017
17 Inhibits Lenvatinib (E7080) - VEGFR-1~3, FGFR-1~4, RET, PDGFR-β, c-kit IC 50 (nm) Target Sorafenib Regorafenib Lenvatinib VEGFR VEGFR VEGFR PDGFR PDGFR-β c-kit FGFR Flt c-raf *IC 50 represents the concentration of a drug that is required to achieve 50% inhibition of the enzyme in a biochemical assay Wilhelm et al. Cancer Res 2004 Selleckchem.com
18 Phase II Trial: Lenvatinib Sorafenib Lenvatinib N Line 1st 1st or 2nd Author Abou-Alfa Ikeda CR or PR (%) SD (%) PFS (median, mo) TTP (median, mo) OS (median, mo) Abou-Alfa et al. J Clin Oncol 2006 Ikeda et al. ESMO 2012
19 REFLECT Study RP III, 1st-line, Lenvatinib vs. Sorafenib Study Schema Cheng et al. ASCO 2017
20 Lenvatinib Lenvatinib demonstrated non-inferiority in overall survival compared to sorafenib in patients with previously untreated advanced HCC Cheng et al. ASCO 2017
21 Lenvatinib Cheng et al. ASCO 2017
22 Lenvatinib Cheng et al. ASCO 2017
23 Lenvatinib Cheng et al. ASCO 2017
24 Lenvatinib Cheng et al. ASCO 2017
25 Lenvatinib Lenvatinib has demonstrated noninferiority versus sorafenib in OS in patients with unresectable HCC (13.6 months for lenvatinib versus 12.3 months for sorafenib) Lenvatinib has achieved statistically significant and clinically meaningful improvement in PFS, TTP, and ORR versus sorafenib in this population The safety profiles of lenvatinib and sorafenib in this study appear consistent with those previously reported in patients with HCC Cheng et al. ASCO 2017
26 inhibit VEGFR, MET, AXL, RET Cabozantinib Kelley et al. Ann Oncol 2017
27 CELESTIAL Trial RP III (2:1), 2nd/3rd-line, Cabozantinib vs. Placebo Abou-Alfa et al. ASCO-GI 2018
28 Cabozantinib Abou-Alfa et al. ASCO-GI 2018
29 Cabozantinib Abou-Alfa et al. ASCO-GI 2018
30 Cabozantinib Abou-Alfa et al. ASCO-GI 2018
31 Cabozantinib Abou-Alfa et al. ASCO-GI 2018
32 Cabozantinib Abou-Alfa et al. ASCO-GI 2018
33 Cabozantinib Abou-Alfa et al. ASCO-GI 2018
34 Cabozantinib Cabozantinib significantly improves overall survival in advanced HCC patients after prior systemic anticancer therapy Progression-free survival and objective response rate were also significantly improved The safety profile is acceptable with a low rate of discontinuation (16%) due to treatment-related adverse events Abou-Alfa et al. ASCO-GI 2018
35 Summary 1L TKI for HCC Sorafenib Levatinib Mechanism VEGFR + Raf? VEGFR + FGFR? Evidence Ph III (vs placebo) Ph III (vs sorafenib) Efficacy (OS) superior to placebo non-inferior to sorafenib Toxicity HFSR Hypertension Comments poor-px Pts excluded modified from Cheng AL. ASCO-GI 2018
36 Summary 2L TKI for HCC Regorafenib Cabozantinib Mechanism VEGFR + Raf? VEGFR + MET? AXL? Evidence Ph III (vs placebo) Ph III (vs placebo) Pt characteristics Efficacy OS RR sorafenib-tolerant (radiologic progression) mo 4 11% sorafenib experienced (11.3) mo 0.4 4% Toxicity HTN, HFSR HFSR, HTN modified from Cheng AL. ASCO-GI 2018
37 Conclusion Perspective of Systemic Therapy for HCC L: Sorafenib, Lenvatinib 2L: Regorafenib, Cabozantinib, Nivolumab
38 감사합니다.
39 Back-up
40 1st-line Agent Trial Yr TTP (mo) OS (mo) Sorafenib SHARP Asia-Pacific SUN LIGHT BRISK-FL Nintedanib REFLECT Lenvatinib REFLECT
41 Why Not TTP? Trial Drug n TTP or PFS (mo) HR P OS (mo) HR P First-line SHARP Sorafenib vs placebo 299 vs vs < vs <0.001 Asia-Pacific Sorafenib vs placebo 150 vs vs vs SUN Sunitinib vs sorafenib 530 vs vs vs LIGHT Linifanib vs sorafenib 514 vs vs < vs NS BRISK-FL Brivanib vs sorafenib 577 vs vs vs Nintedanib Nintetanib vs sorafenib 63 vs vs NS 10.2 vs NS REFLECT Lenvatinib vs sorafenib 478 vs vs < vs Non-inferior First-line in Combination with Sorafenib SEARCH Erlotinib with sorafenib 358 vs vs vs CALGB80802 Doxorubicin with sorafenib 173 vs vs vs Second-line Axitinib Axitinib vs placebo 134 vs vs vs REACH Ramucirumab vs placebo 283 vs vs < vs BRISK-PS Brivanib vs placebo 263 vs vs < vs RESORCE Regorafenib vs placebo 379 vs vs < vs < REACH-2 Ramucirumab vs placebo (AFP 400 ng/ml) Ongoing EVOLVE-1 Everolimus vs placebo 362 vs vs ADI-PEG20 ADI-PEG20 vs placebo 424 vs vs METIV-HCC Tivantinib vs placebo 226 vs vs vs CELESTITIAL Cabozantinib vs placebo 773 (2:1)
12 AISF Special Conference Sorafenib: magnitude of benefit, side effects and stopping rules 9 years after approval
12 AISF Special Conference Sorafenib: magnitude of benefit, side effects and stopping rules 9 years after approval ARMANDO SANTORO Roma 10-6-2016 SORAFENIB APPROVAL 29 OCTOBER 2007 Marketing authorization
More informationRiunione Monotematica A.I.S.F The future of liver diseases. HEPATIC NEOPLASMS The challenge for new drugs
Riunione Monotematica A.I.S.F. 2016 The future of liver diseases Milan 13 th -15 th October 2016 Centro Congressi Fondazione Cariplo HEPATIC NEOPLASMS The challenge for new drugs Massimo Iavarone Gastroenterology
More informationΗπατοκυτταρικός Καρκίνος Συστηματική Θεραπεία. Θωμάς Μακατσώρης Επίκ. Καθ. Παθολογίας-Ογκολογίας Ιατρική Σχολή Πανεπιστημίου Πατρών 11/5/2018
Ηπατοκυτταρικός Καρκίνος Συστηματική Θεραπεία Θωμάς Μακατσώρης Επίκ. Καθ. Παθολογίας-Ογκολογίας Ιατρική Σχολή Πανεπιστημίου Πατρών 11/5/2018 Advisory Board Disclosures Roche, Boeringer, Sanofi, Astra Zeneca,
More informationAdvances in Systemic Therapy Hepatocellular Carcinoma (HCC) Dr ZEE Ying Kiat HASLD Conference Ho Chi Minh City, 18 December 2016
Advances in Systemic Therapy for Hepatocellular Carcinoma (HCC) Dr ZEE Ying Kiat HASLD Conference Ho Chi Minh City, 18 December 2016 Scope Background Staging and treatment strategies Current systemic therapy
More informationIl treatment plan nella terapia sistemica dell epatocarcinoma
Il treatment plan nella terapia sistemica dell epatocarcinoma M. Iavarone, MD PhD CRC A.M. e A. Migliavacca Center for the Study of Liver Disease Division of Gastroenterology and Hepatology Fondazione
More informationNew Therapies in HCC Bruno Sangro Clínica Universidad de Navarra. IdISNA. CIBERehd. Pamplona, Spain
New Therapies in HCC Bruno Sangro Clínica Universidad de Navarra. IdISNA. CIBERehd. Pamplona, Spain PHC 2018 - www.aphc.info EASL-EORTC Guidelines EASL EORTC Guidelines. J Hepatol. 2012;56:908-43. Systemic
More informationCurrent Standards of Care of Hepatocellular Carcinoma? Prof. Mohsen Mokhtar M.D Cairo Univ.
Current Standards of Care of Hepatocellular Carcinoma? Prof. Mohsen Mokhtar M.D Cairo Univ. Disclosures Honoraria Received : Amgen, Astra Zeneca, Bohrengier, Hikma,Hospira, GSK, Lilly, Merck, MSD, Novartis,
More informationNovel Molecular Molecular Therapies In Hepatocarcinoma Prof Eric
Novel Molecular Therapies In Hepatocarcinoma Prof. Eric Raymond Department of Médical Oncology Hôpital Beaujon, Clichy Université Paris 7 Denis Diderot INSERM-U728 eric.raymond@bjn.aphp.fr HCC is a highly
More informationA New Era of Systemic Therapy for Hepatocellular Carcinoma with Regorafenib and Lenvatinib
Published online: March 9, 2017 Editorial A New Era of Systemic Therapy for Hepatocellular Carcinoma with Prof. M. Kudo Editor Liver Cancer Introduction The SHARP study in 2007 [1] and the Asia Pacific
More informationWhen patients fail on molecular targeted therapy: what to do in 2013
When patients fail on molecular targeted therapy: what to do in 2013 For 3 rd APASAL HCC conference on 23 Nov 2013 Dr. Stephen L. Chan Department of Clinical Oncology The Chinese University of Hong Kong
More informationFirst-line therapy for unresectable HCC:
ESMO GI Cancer Preceptorship 15 November 2017 Singapore First-line therapy for unresectable HCC: an oncologist s viewpoint Chiun Hsu, MD, PhD G raduate I n stitute of Oncology, National Taiwan Univers
More informationWhy was HOPE 205 a Positive After Years of Negative Studies?
Why was HOPE 205 a Positive After Years of Negative Studies? Prof. Dr. med. Viktor Grünwald Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation Why do we pursue combinations?
More informationDavid N. Robinson, MD
David N. Robinson, MD Background and Treatment of mrcc Background ~ 64,770 new cases of kidney/renal pelvis cancers will be diagnosed in the US in 2012 with an estimated 13,570 deaths [1] ~ 75% are clear-cell
More informationNew Insights: Systemic Therapy for Advanced Hepatocellular Carcinoma (HCC)
New Insights: Systemic Therapy for Advanced Hepatocellular Carcinoma (HCC) Thomas W.T. Leung Associate Director and Honorary Consultant Comprehensive Oncology Centre Hong Kong Sanatorium and Hospital Hong
More informationLiver and Biliary Tract Cancers Critical Review
Liver and Biliary Tract Cancers Critical Review Lorenza Rimassa Oncologia Medica e Ematologia Humanitas Cancer Center Humanitas Research Hospital Rozzano (Milano) Critical review Oral presentations Melero
More informationIl Tumore del Fegato Prospettive Future nel Trattamento dei Tumori Gastrointestinali
Il Tumore del Fegato Prospettive Future nel Trattamento dei Tumori Gastrointestinali Lorenza Rimassa Medical Oncology Unit Humanitas Cancer Center Humanitas Research Hospital Rozzano (Milano) Disclosures
More informationAngiogenesis and tumor growth
Anti-angiogenic agents: where we are? Martin Reck Department of Thoracic Oncology Hospital Grosshansdorf Germany Angiogenesis and tumor growth Journal of experimental Medicine 1972; 133: 275-88 1 Angiogenesis
More informationA) PUBLIC HEALTH B) PRESENTATION & DIAGNOSIS
Hepatocellular Carcinoma HCC Updated November 2015 by: Dr. Mohammed Alghamdi (Medical Oncology Fellow, University of Calgary), April 2017 by Dr. Jenny Ko (Medical Oncologist, Abbotsford Centre, BC Cancer
More informationTivantinib Overview April 2016
Tivantinib Overview April 2016 Safe Harbor This presentation and other statements by ArQule may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act with
More informationManagement of advanced Hepatocellular carcinoma
Management of advanced Hepatocellular carcinoma V Di Martino* Acknowledgements to T Thevenot *Advisory board/lectures/travel facilities: Case report (1) Mr T. Philippe 55 yrs old Past IV drug user (1985)
More informationSystemic Targeted Therapy Beyond Sorafenib
REVIEW REVIEW Systemic Targeted Therapy Beyond Sorafenib Roniel Cabrera, M.D., M.S. The quest for medical treatments for patients with advanced stage hepatocellular carcinoma (HCC) has met repeated road
More informationPersonalized Management of HCC
Personalized Management of HCC Josep M. Llovet, MD, FAASLD Professor of Medicine. Director, Liver Cancer Program, ISM at Mount Sinai, NYC. Professor of Research-ICREA. BCLC Group-IDIBAPS. Liver Unit. Hospital
More informationAdvances in percutaneous ablation and systemic therapies for hepatocellular carcinoma
Advances in percutaneous ablation and systemic therapies for hepatocellular carcinoma Paris Hepatology Congress 2019 Pierre Nahon Service d Hépatologie Hôpital Jean Verdier Bondy Université Paris 13 INSERM
More informationCisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer. Valle J et al. N Engl J Med 2010;362(14):
Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer Valle J et al. N Engl J Med 2010;362(14):1273-81. Introduction > Biliary tract cancers (BTC: cholangiocarcinoma, gall bladder cancer,
More informationAntiangiogenic therapy in GI cancer: current status and future directions
Riccardo Giampieri, MD, PhD Università Politecnica delle Marche Ospedali Riuniti diancona Antiangiogenic therapy in GI cancer: current status and future directions Before starting Summary - Antiangiogenesis
More informationHCC: Epidemiology. Update on treatment of advanced hepatocellular carcinoma. Incidence of HCC is increasing
Update on treatment of advanced hepatocellular carcinoma Jean-Luc Raoul Centre E Marquis Rennes, Brittany France HCC: Epidemiology Europe - USA: C virus, alcohol obesity, iron Europe: 4 deaths / year 6
More informationAn Update on Hepatocellular Carcinoma. Ed Gane NZ Liver Transplant Unit
An Update on Hepatocellular Carcinoma Ed Gane NZ Liver Transplant Unit Hepatocellular Carcinoma has a High Burden of Disease APSCVIR March 2018 Lung Liver Colon/Rectal Stomach Breast Cervix Uteri Esophagus
More information蕾莎瓦 Nexavar 臨床試驗資料 (HCC 肝細胞癌 )
蕾莎瓦 Nexavar 臨床試驗資料 (HCC 肝細胞癌 ) 1 Sorafenib Improves Survival in Hepatocellular Carcinoma: Results of a Phase III Randomized, -Controlled Trial Josep M. Llovet, Sergio Ricci, Vincenzo Mazzaferro, Philip
More informationA Review in the Treatment Options for Renal Cell Cancer
A Review in the Treatment Options for Renal Cell Cancer Ali McBride, PharmD, MS BCPS, BCOP Clinical Coordinator Hematology/Oncology Department of Pharmacy The University of Arizona Cancer Center RENAL
More informationNexavar in advanced HCC: a paradigm shift in clinical practice
Nexavar in advanced HCC: a paradigm shift in clinical practice Tim Greten Hanover Medical School, Germany Histopathological progression and molecular features of HCC Chronic liver disease Liver cirrhosis
More informationInnovaciones en el tratamiento del ca ncer renal. Enrique Grande
Innovaciones en el tratamiento del ca ncer renal Enrique Grande The enriched inflammatory environment of RCC Chen Z, et al. Nat Rev Cancer 2014 Available agents are expanding across the three eras of arcc
More informationMalignant pleural Mesothelioma: A Year In Review
Malignant pleural Mesothelioma: A Year In Review Rabab Gaafar,MD Prof. Medical Oncology NCI Cairo University National Cancer Institute Conference 2015 ASCO news in Mesothelioma Introduction ASCO news second
More informationRegorafenib from Bayer Submitted to Health Authorities Seeking Approval in Second-Line Treatment of Liver Cancer
News Release Not intended for U.S. and UK Media Bayer AG Communications, Government Relations & Corporate Brand 51368 Leverkusen Germany Tel. +49 214 30-0 www.news.bayer.com Regorafenib from Bayer Submitted
More informationSequencing of therapies in mrcc. Ari Hakimi MD Assistant Professor Urology Service, Department of Surgery MSKCC
Sequencing of therapies in mrcc Ari Hakimi MD Assistant Professor Urology Service, Department of Surgery MSKCC Old Paradigm Sequencing approved agents VEGF TKI Sunitinib Pazopanib Axitinib TKI TKI MTORi
More informationHave Results of Recent Randomized Trials Changed the Role of mtor Inhibitors?
Have Results of Recent Randomized Trials Changed the Role of mtor Inhibitors? Bernard Escudier Institut Gustave Roussy Villejuif, France EIKCS Lyon April 2015 What is the current role of mtor inhibitors?
More informationNegative Trials in RCC: Where Did We Go Wrong? Can We Do Better?
Negative Trials in RCC: Where Did We Go Wrong? Can We Do Better? 9 th European Kidney Cancer Symposium, Dublin, April 2014 Tim Eisen Tim Eisen - Disclosures Company Research Support Advisory Board Trial
More informationMedical Management of Renal Cell Carcinoma
Medical Management of Renal Cell Carcinoma Lin Mei, MD Hematology-Oncology Fellow Hematology, Oncology and Palliative Care Virginia Commonwealth University Educational Objectives Background of RCC (epidemiology,
More informationHepatocellular Carcinoma
Hepatocellular Carcinoma Ghassan K. Abou-Alfa Memorial Sloan Kettering Cancer Center Great Debates & Updates in GI Malignancies New York, NY March 28, 2015 Epidemiology Scoring and staging Agenda Curative
More informationCarcinoma de Tiroide: Teràpies Diana
Carcinoma de Tiroide: Teràpies Diana Jaume Capdevila, MD GI and Endocrine Tumor Unit Vall d Hebron University Hospital Developmental Therapeutics Unit Vall d Hebron Institute of Oncology THYROID CANCER:
More informationHepatocellular Carcinoma HCC Updated November 2015 by: Dr. Mohammed Alghamdi (Medical Oncology Fellow, University of Calgary)
Hepatocellular Carcinoma HCC Updated November 2015 by: Dr. Mohammed Alghamdi (Medical Oncology Fellow, University of Calgary) Staff Reviewers: Dr. Yoo Joung Ko (Medical Oncologist, Sunnybrook Odette Cancer
More informationFifteenth International Kidney Cancer Symposium
The following presentation should not be regarded as an endorsement of a particular product/drug/technique by the speaker. The presentation topics were assigned to the speakers by the scientific committee
More informationNSCLC 2 nd and further line therapies. Egbert F. Smit MD PhD. Dept. Thoracic Oncology, Netherlands Cancer Institute
NSCLC 2 nd and further line therapies Egbert F. Smit MD PhD. Dept. Thoracic Oncology, Netherlands Cancer Institute e.smit@nki.nl ESMO Guidelines 2016: Treatment of Stage IV nonsquamous NSCLC at progression
More informationStudy Objective and Design
Randomized, Open Label, Multicenter, Phase II Trial of Transcatheter Arterial Chemoembolization (TACE) Therapy in Combination with Sorafenib as Compared With TACE Alone in Patients with Hepatocellular
More informationBenefit-Risk Summary of Regorafenib for the Treatment of Patients with Advanced Hepatocellular Carcinoma That Has Progressed on Sorafenib
Regulatory Issues: FDA Benefit-Risk Summary of Regorafenib for the Treatment of Patients with Advanced Hepatocellular Carcinoma That Has Progressed on Sorafenib LORRAINE PELOSOF, STEVEN LEMERY, SANDRA
More informationDevelopping the next generation of studies in RCC
Developping the next generation of studies in RCC Bernard Escudier Institut Gustave Roussy Villejuif, France Disclosure Information Advisory/Consultancy Role Pfizer, Exelixis, Novartis, BMS, Bayer, Roche,
More informationMetastatic renal cancer (mrcc): Evidence-based treatment
Metastatic renal cancer (mrcc): Evidence-based treatment José M. Ruiz Morales, M.D. Hospital Médica Sur April 18th, 2018 4th ESO-ESMO Latin American Masterclass in Clinical Oncology Disclosures Consulting:
More informationAntiangiogenic Agents in NSCLC Where are we? Which biomarkers? VEGF Is the Only Angiogenic Factor Present Throughout the Tumor Life Cycle
Antiangiogenic Agents in NSCLC Where are we? Which biomarkers? Martin Reck Department e t of Thoracic c Oncology ogy Hospital Grosshansdorf Germany VEGF Is the Only Angiogenic Factor Present Throughout
More informationLenvatinib May Drastically Change the Treatment Landscape of Hepatocellular Carcinoma
Received: January 25, 2018 Accepted: January 25, 2018 Published online: February 15, 2018 Editorial May Drastically Change the Treatment Landscape of Hepatocellular Masatoshi Kudo Department of Gastroenterology
More informationLiver and Biliary Tract Cancers Highlights
Liver and Biliary Tract Cancers Highlights A cura di Lorenza Rimassa, MD Medical Oncology Unit, Humanitas Research Hospital IRCCS, Rozzano (Milano) Disclosures Consulting or Advisory Role: Lilly, Bayer,
More informationImmune Checkpoint Inhibitors for Lung Cancer William N. William Jr.
Immune Checkpoint Inhibitors for Lung Cancer William N. William Jr. Diretor de Onco-Hematologia Hospital BP, A Beneficência Portuguesa Non-Small Cell Lung Cancer PD-1/PD-L1 Inhibitors in second-line therapy
More informationSergio Bracarda MD. Head, Medical Oncology Department of Oncology AUSL-8 Istituto Toscano Tumori (ITT) San Donato Hospital Arezzo, Italy
Sergio Bracarda MD Head, Medical Oncology Department of Oncology AUSL-8 Istituto Toscano Tumori (ITT) San Donato Hospital Arezzo, Italy Ninth European International Kidney Cancer Symposium Dublin 25-26
More informationI Kid(ney) You Not: Updates on Renal Cell Carcinoma
Disclosures I Kid(ney) You Not: Updates on Renal Cell Carcinoma Nothing to disclose Renee McAlister, PharmD, BCOP Clinical Pharmacist, GU/Melanoma Vanderbilt Ingram Cancer Center September 29, 2018 Objectives
More informationSorafenib in HCC. Discussion points
Discussion points in Andrew X. Zhu, MD, PhD 214 CASL Meeting-Consensus, Controversies and Future Directions in -data from phase III trials ptimal Dosing Side effects and management strategies use in Child-Pugh
More informationBackground. Capdevila J, et al. Ann Oncol. 2018;29(Suppl 8): Abstract 1307O. 1. Dasari A, et al. JAMA Oncol. 2017;3(10):
Efficacy of Lenvatinib in Patients With Advanced Pancreatic (pannets) and Gastrointestinal (ginets) WHO Grade 1/2 (G1/G2) Neuroendocrine Tumors: Results of the International Phase II TALENT Trial (GETNE
More informationAddictive Benefit of Transarterial Chemoembolization and Sorafenib in Treating Advanced Stage Hepatocelluar Carcinoma: Propensity Analysis
Addictive Benefit of Transarterial Chemoembolization and Sorafenib in Treating Advanced Stage Hepatocelluar Carcinoma: Propensity Analysis Gwang Hyeon Choi, Ju Hyun Shim*, Min-Joo Kim, Min-Hee Ryu, Baek-Yeol
More informationEvidenze cliniche nel trattamento del RCC
Criteri di scelta nel trattamento sistemico del carcinoma renale Evidenze cliniche nel trattamento del RCC Alessandro Morabito Unità Sperimentazioni Cliniche Istituto Nazionale Tumori di Napoli Napoli,
More informationThe following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only.
The following slides are provided as presented by the author during the live educa7onal ac7vity and are intended for reference purposes only. If you have any ques7ons, please contact Imedex via email at:
More informationHepatocellular Carcinoma (HCC)
Hepatocellular Carcinoma (HCC) Matthias Pinter Div. Gastroenterology & Hepatology Medical University of Vienna Agenda Epidemiology Screening & Diagnosis Staging & Treatment Early stage Intermediate stage
More informationLatest Developments in the Treatment of Hepatocellular Carcinoma
Latest Developments in the Treatment of Hepatocellular Carcinoma Roniel Cabrera, MD MS Associate Professor of Medicine Director of Hepatology and Medical Director of Liver Transplantation Division of Gastroenterology,
More informationTargeted Agents as Maintenance Therapy. Karen Kelly, MD Professor of Medicine UC Davis Cancer Center
Targeted Agents as Maintenance Therapy Karen Kelly, MD Professor of Medicine UC Davis Cancer Center Disclosures Genentech Advisory Board Maintenance Therapy Defined Treatment Non-Progressing Patients Drug
More informationASCO 2012 Genitourinary tumors
ASCO 2012 Genitourinary tumors Post ASCO Bern 14-06-2012 Dr. med. Richard Cathomas leitender Arzt Onkologie, KSGR, Chur Renal cell cancer Changes in first line treatment? Prostate cancer 3 positive phase
More information2 nd line Therapy and Beyond NSCLC. Alan Sandler, M.D. Oregon Health & Science University
2 nd line Therapy and Beyond NSCLC Alan Sandler, M.D. Oregon Health & Science University Treatment options for advanced or metastatic (stage IIIb/IV) NSCLC Suitable for chemotherapy Diagnosis Unsuitable/unwilling
More informationRegulatory Considerations in Oncology Trials in China. Jiang, Frank, MD, PhD VP, Asia Pacific R&D, Sanofi
Regulatory Considerations in Oncology Trials in China Jiang, Frank, MD, PhD VP, Asia Pacific R&D, Sanofi 1 Disclaimer The views and opinions provided are those of the speaker and do not reflect those of
More informationI. Diagnosis of the cancer type in CUP
Latest Research: USA I. Diagnosis of the cancer type in CUP II. Outcomes of site-specific therapy of the cancer type in CUP a. Prospective clinical trial b. Retrospective clinical trials 1 Latest Research:
More informationTreatment options after sorafenib failure in patients with hepatocellular carcinoma
pissn 2287-2728 eissn 2287-285X Review Clinical and Molecular Hepatology 2017;23:273-279 Treatment options after sorafenib failure in patients with hepatocellular carcinoma Imane El Dika 1 and Ghassan
More informationThe Role of Angiogenesis Inhibition in Breast Cancer Today: Lessons Learned
The Role of Angiogenesis Inhibition in Breast Cancer Today: Lessons Learned Hope S. Rugo, MD Professor of Medicine Director, Breast Oncology and Clinical Trials Education UCSF Helen Diller Family Comprehensive
More informationHepatozelluläres Karzinom und Cholangiokarzinom was kommt nach Sorafenib? Stefan Kubicka
Hepatozelluläres Karzinom und Cholangiokarzinom was kommt nach Sorafenib? Stefan Kubicka SHARP 1 versus Asia-Pacific-Study 2 SHARP S:299/P:303 Asia-Pacific S:150/P:76 End point HR p-value HR p-value OS
More informationMANAGEMENT OF THYROID MALIGNANCIES
MANAGEMENT OF THYROID MALIGNANCIES Taofeek K. Owonikoko, MD, PhD Associate Professor Department of Hematology/Medical Oncology Winship Cancer Institute of Emory University Atlanta, GA 1 Disclosures Research
More informationNEXT GENERATION DRUGS IN KIDNEY CANCER. Dr Aine O Reilly Karolinska Institutet Stockholm, Sweden
NEXT GENERATION DRUGS IN KIDNEY CANCER Dr Aine O Reilly Karolinska Institutet Stockholm, Sweden KIDNEY CANCER SUBTYPES Papillary Type 1 and 2 Medullary Collecting duct Chromophobe Translocation Clear cell
More information현재임상시험중인기대되는 간세포암종치료법
현재임상시험중인기대되는 간세포암종치료법 New Options, Emerging Combinations in Advanced Hepatocellular Carcinoma Department of Internal Medicine, School of Medicine, Kyungpook National University Soo Young Park 179 Studies
More informationLa revolución de la inmunoterapia: dónde la posicionamos? Javier Puente, MD, PhD
La revolución de la inmunoterapia: dónde la posicionamos? Javier Puente, MD, PhD Hospital Universitario Clinico San Carlos Medical Oncology Department Thoracic & Urological Cancer Unit Complutense University
More informationJefferies 2014 Global Healthcare Conference. June 5, 2014
Jefferies 2014 Global Healthcare Conference June 5, 2014 ArQule, Inc. Safe Harbor This presentation and other statements by ArQule may contain forwardlooking statements within the meaning of the Private
More informationRenal Cell Carcinoma: Systemic Therapy Progress and Promise
Renal Cell Carcinoma: Systemic Therapy Progress and Promise Michael B. Atkins, M.D. Deputy Director, Lombardi Comprehensive Cancer Ctr Georgetown University Medical Center Everolimus Rini, Campbell, Escudier.
More informationJon Trent, MD, PhD. Associate Professor Dept. of Sarcoma Medical Oncology The University of Texas, M. D. Anderson Cancer Center
Gastrointestinal Stromal Tumor GISTS 2010: After Standard of Care Jon Trent, MD, PhD Associate Professor Dept. of Sarcoma Medical Oncology The University of Texas, M. D. Anderson Cancer Center jtrent@mdanderson.org
More informationpan-canadian Oncology Drug Review Stakeholder Feedback on a pcodr Request for Advice Axitinib (Inlyta) for Metastatic Renal Cell Carcinoma
pan-canadian Oncology Drug Review Stakeholder Feedback on a pcodr Request for Advice Axitinib (Inlyta) for Metastatic Renal Cell Carcinoma Pfizer Canada Inc. June 29, 2017 3 Stakeholder Feedback on a pcodr
More informationJuly, ArQule, Inc.
July, 2012 Safe Harbor This presentation and other statements by ArQule may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act with respect to clinical
More informationMaintenance therapy in advanced non-small cell lung cancer. Egbert F. Smit MD PhD Dept Thoracic Oncology Netherlands Cancer Institute
Maintenance therapy in advanced non-small cell lung cancer. Egbert F. Smit MD PhD Dept Thoracic Oncology Netherlands Cancer Institute e.smit@nki.nl Evolution of front line therapy in NSCLC unselected pts
More informationEGFR Mutation-Positive Acquired Resistance: Dominance of T790M
Treatment of EGFR Mutation-Positive Acquired Resistance: T790M+ or T790M- H. Jack West, MD Swedish Cancer Institute, Seattle, WA EGFR Mutation-Positive Acquired Resistance: Dominance of T790M Yu, Clin
More informationSecond - Line Debate: Axitinib
Second - Line Debate: Axitinib Alain Ravaud, MD PhD Bordeaux, France DISCLOSURES Member of Global, European and/or French advisory board in RCC and/or GU tumors for Pfizer, Novartis, GSK, Roche, BMS, Merck.
More informationRandomized Controlled Phase 2 Trial (RCT) ARQ
Tivantinib in Pretreated Hepatocellular Carcinoma (HCC): Tumor and Plasma Biomarker Analysis from the Randomized Controlled Phase 2 Trial (RCT) ARQ 197-215 L Rimassa, G Abbadessa, N Personeni, C Porta,
More informationCurrent Concepts in the Treatment of HCC
Falk Symposium 167 Current Concepts in the Treatment of HCC Peter R. Galle I. Medical Department Johannes Gutenberg-University Mainz Germany Liver cancer: sixth most common cancer worldwide Most common
More informationHEPATIC RESECTION AND percutaneous
bs_bs_banner doi: 10.1111/hepr.13259 Review Article Recent advances in medical management of hepatocellular carcinoma Kenji Ikeda Department of Hepatology, Toranomon Hospital, Tokyo, Japan Transcatheter
More informationMetastatic Renal Cancer Medical Treatment
Metastatic Renal Cancer Medical Treatment Bohuslav Melichar, M.D., Ph.D. Professor and Head Department of Oncology Palacký University Medical School and Teaching Hospital Olomouc, Czech Republic Peculiarities
More informationTargeted and immunotherapy in RCC
Targeted and immunotherapy in RCC Treatment options Surgery (radical VS partial nephrectomy) Thermal ablation therapy Surveillance Immunotherapy Molecular targeted therapy Molecular targeted therapy Targeted
More informationLong Term Results in GIST Treatment
Long Term Results in GIST Treatment Dr. Laurentia Gales Prof. Dr. Rodica Anghel, Dr. Xenia Bacinschi Institute of Oncology Prof Dr Al Trestioreanu Bucharest 25 th RSRMO October 15-17 Sibiu Background Gastrointestinal
More informationEmerging Biomarkers of VEGF and mtor Inhibitors in 2015
Emerging Biomarkers of VEGF and mtor Inhibitors in 2015 Laurence Albiges Institut Gustave Roussy, France Fourteenth International Kidney Cancer Symposium Miami, Florida, USA November 6-7, 2015 www.kidneycancersymposium.com
More informationDesign of Clinical Trials with Molecularly Targeted Therapies. Gilberto Schwartsmann
Design of Clinical Trials with Molecularly Targeted Therapies Gilberto Schwartsmann What are the basics of clinical trial design? Presented By Jordan Berlin at 2016 ASCO Annual Meeting Advances in molecular
More informationPlotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma
Pieter E. Postmus University of Liverpool Liverpool, UK Plotting the course: optimizing treatment strategies in patients with advanced adenocarcinoma Disclosures Advisor Bristol-Myers Squibb AstraZeneca
More informationDevelopment of New Treatment Modalities Oncolytic Viruses and Nanotechnique
Development of New Treatment Modalities Oncolytic Viruses and Nanotechnique By Professor Kjell Öberg, M.D., Ph.D. Dept. of Endocrine Oncology, University Hospital, Uppsala, Sweden Nashville Oct. 2011 Hallmarks
More informationArQule Jefferies Global Healthcare Conference June 2015
ArQule Jefferies Global Healthcare Conference June 2015 1 ArQule Corporate Update Safe Harbor This presentation and other statements by ArQule may contain forward-looking statements within the meaning
More informationIncorporating Immunotherapy into the treatment of NSCLC
Incorporating Immunotherapy into the treatment of NSCLC Suresh S. Ramalingam, MD Roberto C. Goizueta Chair for Cancer Research Assistant Dean for Cancer Research Deputy Director, Winship Cancer Institute
More informationK-Ras signalling in NSCLC
Targeting the Ras-Raf-Mek-Erk pathway Egbert F. Smit MD PhD Dept. Pulmonary Diseases Vrije Universiteit VU Medical Centre Amsterdam, The Netherlands K-Ras signalling in NSCLC Sun et al. Nature Rev. Cancer
More informationContemporary Chemotherapy-Based Strategies for First-Line Metastatic Breast Cancer
Contemporary Chemotherapy-Based Strategies for First-Line Metastatic Breast Cancer Hope S. Rugo, MD Professor of Medicine Director, Breast Oncology and Clinical Trials Education University of California
More informationBeyond ALK and EGFR: Novel molecularly driven targeted therapies in NSCLC Federico Cappuzzo AUSL della Romagna, Ravenna, Italy
Beyond ALK and EGFR: Novel molecularly driven targeted therapies in NSCLC Federico Cappuzzo AUSL della Romagna, Ravenna, Italy Oncogenic drivers in NSCLC Certain tumours arise as a result of aberrant activation
More informationAntiangiogenics are effective treatments in NETs
RENET: A randomized phase III trial comparing REgorafenib to placebo in patients with advanced, progressive, well-differentiated NEuroendocrine Tumors (NETs). Coordinators: Dr Julien Hadoux & Dr David
More informationAn Open-Label Phase Ib/II Study of Sulfatinib in Patients with Advanced Neuroendocrine Tumors (NCT )
An Open-Label Phase Ib/II Study of Sulfatinib in Patients with Advanced Neuroendocrine Tumors (NCT02267967) J.M. Xu a, J. Li b, C.M. Bai c, N. Xu d, Z.W. Zhou e, Z.P. Li f, C.C. Zhou g, W. Wang h, J. Li
More informationCLINICAL CHALLENGES IN METASTATIC RENAL CELL CARCINOMA: THE RIGHT THERAPY FOR THE RIGHT PATIENT
Daniel Heng, MD, MPH, FRCPC @DrDanielHeng Chair GU Tumour Group, Tom Baker Cancer Centre Clinical Professor, University of Calgary CLINICAL CHALLENGES IN METASTATIC RENAL CELL CARCINOMA: THE RIGHT THERAPY
More informationImmunotherapy in the clinic. Lung Cancer. Marga Majem 20 octubre 2017
Immunotherapy in the clinic. Lung Cancer Marga Majem 20 octubre 2017 mmajem@santpau.cat Immunotherapy in the clinic. Lung Cancer Agenda Where we come from? Immunotherapy in Second line Immunotherapy in
More informationNintedanib in Oncology Backgrounder
For media outside the US, UK and Canada only Nintedanib in Oncology Backgrounder 1. What is nintedanib? 2. How does nintedanib work? 3. Data overview 4. Additional clinical data 5. Nintedanib approval
More informationDevelopmental Therapeutics for HCC, Colorectal Cancer, and Pancreatic Cancer. Manish Sharma, MD Developmental Therapeutics Symposium April 20, 2018
Developmental Therapeutics for HCC, Colorectal Cancer, and Pancreatic Cancer Manish Sharma, MD Developmental Therapeutics Symposium April 20, 2018 Disclosure Information 23 rd Annual Developmental Therapeutics
More information