Histopathology of Endoscopic Resection Specimens from Barrett's Esophagus

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1 Histopathology of Endoscopic Resection Specimens from Barrett's Esophagus

2 Br J Surg 38 oct. 1950

3 Definition of Barrett's esophagus A change in the esophageal epithelium of any length that can be recognized at endoscopy and is confirmed to have columnar epithelium / intestinal metaplasia by biopsy. Practice Parameters Committee of American College of Gastroenterology, Am J Gastroenterol 1998;93: British Society of Gastroenterology (BSG), Gut 2006;55:44

4 Endoscopy Gastroesophageal junction: Western world: Proximal border of gastric folds. Japan: Pallisading longitudinal vessels.

5 Pathology Squamo-columnar junction: USA: specialized intestinal metaplasia. UK/Japan: all columnar metaplasia. Europe: specialized intestinal metaplasia.

6 Gross anatomy of a BE resection specimen Squamocolumnar junc/on

7 Define Barrett's in Biopsy Definition: A change in the esophageal epithelium of any length recognized at endoscopy and confirmed to have columnar epithelium / IM by biopsy. Challenge for pathologist: Define origin of the biopsy. Identify intestinal metaplasia.

8 Biopsy distal esophagus: Barrett?

9 Biopsy distal esophagus: Barrett? Gastric type mucosa. Intestinal metaplasia? Differential includes hiatus hernia.

10 Biopsy distal esophagus: Barrett?

11 Multilayered Epithelium with Pseudogoblets

12 Intestinal Metaplasia vs Pseudogoblet cells

13 Definition of Barrett's: Mucin Histochemistry

14 Definition of Barrett's: CDX2 Expression

15 Diagnostic of Barrett's: Esophageal Duct

16 Diagnostic of Barrett's: Squamous Patches

17 Distal Esophagus: Barrett's? Dysplasia?

18 Revised Vienna Classification of Gastrointestinal Epithelial Neoplasia 1. Negative for dysplasia 2. Indefinite for dysplasia 3. Low grade dysplasia 4. Mucosal high-grade neoplasia (HGD) - High grade adenoma / dysplasia - Non invasive carcinoma (CIS) - Intramucosal carcinoma 5. Submucosal invasion by carcinoma Schlemper RJ et al. J Gastroenterol 2001;36:

19 Based on the Revised Vienna Classification No dysplasia Indefinite for dysplasia Low grade dysplasia High grade dysplasia Intramucosal carcinoma Invasive adenocarcinoma

20 Biopsy Report Intestinal metaplasia. When dysplasia is present, grade. HGD / EAC does not automatically implicate esophagectomy anymore. Local resection (mucosectomy) as staging modality.

21 Multiband Mucosectomy (MBM) ligate-and-cut

22 ER-Cap Technique lift-suck-and-cut

23 Preperation of ER specimen Endoscopist should loosely pin down specimen on paraffin block or cork to prevent from curling up (creates artefact). Deliver up-side-down (specimen down) in formalin and fixate overnight.

24 Usually non- marked specimen, photograph, ink,

25 Slices, each 2 to 3 mm

26 2 to 3 slices per casece 2 to 3 secdons per slice

27

28

29

30

31

32

33

34

35 Conclusion ER Specimen Dysplasia / carcinoma / type Differentiation grade Depth of invasion Submucosal invasion Vaso-invasion Vertical margin (mm) / radicality Lateral margin (not in piecemeal resection) Intestinal metaplasia

36 Risk Factors Essential in sign out, relative risk factors for esophagectomy: 1. Invasion in submucosa. 2. Poor differentiation grade (solid tumor, signet cell carcinoma). 3. Vaso-invasive growth.

37 Risk Factor: Submucosal Mucosal vs Submucosal Disease M1 high grade dysplasia. M2 intramucosal carcinoma confined to lamina propria. M3 intramucosal carcinoma invasion in musc. mucosa. SM-1: - 500mm of the submucosa. SM-2: 500mm-1000mm. SM-3: > 1000mm.

38 Westerterp et al Vieth et al pt1 (m1) pt1 (m2) pt1 (m3) pt1 (m1) pt1 (m2) pt 1 (m1) pt 1 (m2) pt 1 (m3) Sm-1 pt1 (m3) Sm-1 pt 1 (m4) Sm-1

39 Risk Factor: Submucosal

40

41 Desmin stain

42 Invasion in Muscularis Mucosae?

43 p53 IHC tumor tumor Esophageal duct

44 Extensive Esophageal Gland Involvement

45 Submucosal Invasion?

46 Risk Factor: Poor Differentiation

47 Risk Factor: Vaso-invasive Growth

48 Vaso-invasive Growth

49 Vaso-invasive Growth

50 Vaso-invasive Growth

51 Extension in Esophageal Duct CD31 IHC

52 Patient 29 years old

53

54 Surgical Resection Specimen

55 microscopic tumor focus

56 2 of 16 Lymph Nodes Show Metastasis

57 Summary ER Prevent non-interpretable slide. Train endoscopist for pinning down. Gross: train resident (staff). Parallel slices at regular interval (2-3 mm). Not too many slices per block. Train lab technician in cutting slides.

58 Summary ER Analyze for risk factors: radicality poor differentiation submucosal invasion vaso-invasive growth Lateral margin not important in piecemeal resection.

59 Summary ER Use full stains: desmin and p53. Don t overestimate depth of invasion at the edge of specimen (desmin stain). Don t overestimate non-radical excision needle artefact.

60 Questions?

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