Chronic diarrhea. Dr.Nasser E.Daryani Professor of Tehran Medical University
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2 Chronic diarrhea Dr.Nasser E.Daryani Professor of Tehran Medical University
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4 Timing Acute diarrhea: <2 weeks Persistent diarrhea: 2-4 weeks Chronic diarrhea: > 4 weeks
5 Definitions Derived from Greek to flow through Increased stool water content / fluidity Increased stool weight > 200 gm/d 3 or more BMs daily is generally abnormal Rule out fecal incontinence
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8 Normal stool fluids processing 8-9 L/d enter GI system Ingest 1-2 L/d Create approx 7 L/d saliva, gastric, biliary, pancreatic secretions Small bowel reabsorbs 6-7 L/d Large bowel absorbs 1-2 L/d gm/d stool created Reduction of water absorption, due to decrease in absorption or increase in secretion, by as little as 1% can lead to diarrhea
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16 Differential Diagnosis: Watery (Secretory) Diarrhea Bacterial toxins Abnormal motility DM-related dysfunction IBS Post-vagotomy diarrhea Diverticulitis Ileal bile acid malabsorption Malignancy Colon CA Lymphoma Rectal villous ademoma Vasculitis Congenital chloridorrhea Inflammatory Microscopic colitis Endocrinopathies Hyperthyroidism Adrenal insufficiency Cardinoid syndrome Gastrinoma, VIPoma, Somatostatinoma Pheochromocytoma Idiopathic Epidemic (Brainerd) Sporadic Medications, stimulant laxative abuse, toxins
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30 Causes of Diarrhea Osmotic Ingestion of poorly absorbed agent (eg, magnesium) Loss of nutrient transporter (eg, lactase deficiency) Secretory Exogenous secretagogues (eg, cholera toxin) Endogenous secretagogues (eg, NE tumor) Absence of ion transporter (eg, congenital chloridorrhea) Loss of intestinal surface area (eg, diffuse mucosal disease IBD, celiac; surgical resection) Intestinal ischemia Rapid intestinal transit (eg, dumping syndrome)
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32 Differential Diagnosis: Fatty Diarrhea Maldigestion = inadequate breakdown of triglycerides Pancreatic exocrine insufficiency (eg, chronic pancreatitis) Inadequate luminal bile acid concentration (eg, advanced primary biliary cirrhosis) Malabsorption = inadequate mucosal transport of digestion products Mucosal diseases (eg, Celiac sprue, Whipple s disease) Mesenteric ischemia Structural disease (eg, short bowel syndrome) Small intestinal bacterial overgrowth (bile salt deconjugation)
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40 Differential Diagnosis: Inflammatory Diarrhea IBD (Crohn s, UC) Ischemic colitis Malignancy Colon CA Lymphoma Diverticulitis Radiation colitis Infectious Invasive bacterial (Yersinia, TB) Invasive parasitic (Amebiasis, strongyloides) Pseudomembranous colitis (C diff infection) Ulcerating viral infections (CMV, HSV)
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45 Initial Evaluation: History Duration, pattern, epidemiology Severity, dehydration Stool volume & frequency Stool characteristics (appearance, blood, mucus, oil droplets, undigested food particles) Nocturnal symptoms Fecal urgency, incontinence Associated sx (abd pain, cramps, bloating, fever, weight loss, etc) Extra-intestinal symptoms Relationship to meals, specific foods, fasting, & stress Medical, surgical, travel, water exposure hx Recent hospitalizations, antibiotics History of radiation Current/recent medications Diet (including excessive fructose, sugar alcohols, caffeine Sexual orientation Possibility of laxative abuse
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47 Initial Evaluation: Physical Examination Most useful in determining severity of diarrhea Orthostatic changes Fever Bowel sounds (or lack thereof) Abdominal distention, tenderness, masses, evidence of prior surgeries Hepatomegaly DRE including FOBT Skin, joints, thyroid, peripheral neuropathy, murmur, edema
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51 Initial Evaluation: Testing CBC w/ differential (Hct, MCV, WBC count) CMP (electrolytes, BUN /Cr, glucose, LFTs, Ca, albumin) TSH, B12, folate, INR/PTT, Vit D, iron, ESR, CRP, Amoeba Ab, anti-transglutaminase IgA Ab, anti-endomyseal IgA Ab, HIV Stool studies Culture (more useful only for acute), O&P, Giardia Ag, C diff, Coccidia, Microsporidia, Cryptosporidiosis
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