Panel Discussion/References
|
|
- Quentin Lynch
- 5 years ago
- Views:
Transcription
1 Follicular Lymphoma (FOLL) Panel discussion to reassess the category designation for lenalidomide + rituximab as a firstline therapy for FL. Panel discussion to reassess the inclusion of radioimmunotherapy as first-line consolidation or extended dosing for FL. Based on the discussion regarding the data in the noted references for lenalidomide + rituximab as a first-line therapy for FL, the panel consensus vote resulted in a category change from a category 3 to a category 2B recommendation. Martin P, Jung S-H, Johnson JL, et al. CALGB (Alliance): A phase II trial of lenalidomide plus rituximab in patients with previously untreated follicular lymphoma [abstract]. J Clin Oncol 2014;32:Abstract Fowler N, Davis R, Rawal S, et al. Safety and activity of lenalidomide and rituximab in untreated indolent lymphoma: an open-label, phase 2 trial. The Lancet Oncology 2014;15: Based on the panel discussion regarding the long-term toxicity associated with radioimmunotherapy and superiority of maintenance rituximab for the treatment of FL, the panel consensus vote resulted in the radioimmunotherapy category changing from a category 2A to a category 2B recommendation. YES NO ABSTAIN ABSENT Panel discussion to add a qualifier statement for the use of idelalisib as second-line and subsequent therapy for FL. Based on the on the discussion of data from the multicenter phase II trial (noted in the reference below) that evaluated idelalisib in patients with patients with indolent NHL who had received extensive prior treatment, the panel consensus was to include the qualifier statement refractory to both alkylator and rituximab for the use of idelalisib as second-line and subsequent therapy for FL, to be consistent with the eligibility criteria that were used in the aforementioned trial. Gopal A, Kahl B, De Vos S, et al. PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphoma. N Engl J Med 2014;370:
2 External request Submission from Genentech, inc to consider the overall survival results for the follicular lymphoma patient population from the GADOLIN study and the following new FDA-approved indication for obinutuzumab: obinutuzumab is indicated in combination with bendamustine followed by obinutuzumab monotherapy, for the treatment of patients with follicular lymphoma who relapsed after, or are refractory to, a rituximab containing regimen. Based on the submitted references and discussion, the panel consensus was to include bendamustine + obinutuzumab as an option for second-line and subsequent therapy for FL. This was added as a category 2A recommendation. See submission for references Panel discussion to determine if the data to support bendamustine + obinutuzumab is category 1 level evidence for second-line and subsequent therapy for FL. In the aforementioned GADOLIN study, patients with indolent NHL refractory to rituximab were randomized to bendamustine plus obinutuzumab or bendamustine monotherapy. Non-progressing patients in the bendamustine plus obinutuzumab group received obinutuzumab maintenance. Although bendamustine plus obinutuzumab followed by obinutuzumab maintenance had improved efficacy over bendamustine monotherapy, based on the study design (noted above), the panel consensus was that the available evidence does not support the inclusion of bendamustine + obinutuzumab with a category 1 recommendation Sehn LH, Chua NS, Mayer J, et al. GADOLIN: Primary results from a phase III study of obinutuzumab plus bendamustine compared with bendamustine alone in patients with rituximabrefractory indolent non-hodgkin lymphoma [abstract]. J Clin Oncol 2015;33(15_ suppl):abstract LBA8502. Panel discussion to reassess the category designation for obinutuzumab maintenance for rituximab-refractory disease for second-line consolidation of FL. Based on the discussion for obinutuzumab maintenance for rituximab-refractory disease for second-line consolidation of FL, the panel consensus vote resulted in a category change from a category 2B to a category 2A recommendation
3 Mantle Cell Lymphoma (MANT) consider the inclusion of lenalidomide + rituximab as a less aggressive induction therapy option. Based on the noted reference and discussion, the panel consensus was to include lenalidomide + rituximab as a less aggressive induction therapy option. This was added as a category 2A recommendation. Ruan J, Martin P, Shah B, et al. Lenalidomide plus rituximab as initial treatment for mantle-cell lymphoma. N Engl J Med 2015;373: YES NO ABSTAIN ABSENT consider the inclusion of bendamustine, bortezomib and rituximab as a second-line fludarabine, cyclophosphamide ± rituximab as a second-line fludarabine, cyclophosphamide, mitoxantrone, and rituximab as a second-line treatment option for patients with Based on the noted reference and discussion, the panel consensus was to include bendamustine, bortezomib and rituximab as a secondline This was added as a category 2B recommendation. Friedberg JW, Vose JM, Kelly JL, et al. The combination of bendamustine, bortezomib, and rituximab for patients with relapsed/refractory indolent and mantle cell non-hodgkin lymphoma. Blood 2011;117: Based on the panel discussion regarding the limited data and activity for fludarabine, cyclophosphamide ± rituximab for the second-line treatment of FL, the panel consensus vote resulted in the category changing from a category 2A to a category 3 recommendation. The panel discussion and consensus was that fludarabine, cyclophosphamide, mitoxantrone, and rituximab should be removed as a second-line treatment option for MCL due to limited clinical use and activity
4 fludarabine, mitoxantrone and rituximab as a second-line pentostatin, cyclophosphamide and rituximab as a second-line prednisone, etoposide, procarbazine, cyclophosphamide ± rituximab as a second-line Discussion comment to consider the inclusion of venetoclax as a second-line treatment option for patients with The panel discussion and consensus was that fludarabine, mitoxantrone and rituximab should be removed as a second-line treatment option for MCL due to limited clinical use and activity. Based on the panel discussion regarding the limited data and activity for pentostatin, cyclophosphamide and rituximab for the second-line treatment of FL, the panel consensus vote resulted in the category changing from a category 2A to a category 3 recommendation. Based on the panel discussion regarding the limited data and activity for prednisone, etoposide, procarbazine, cyclophosphamide ± rituximab for the second-line treatment of FL, the panel consensus vote resulted in the category changing from a category 2A to a category 3 recommendation. Based on the noted reference and discussion, the panel consensus was to include venetoclax as a second-line treatment option for patients with This was added as a category 2A recommendation. Gerecitano JF et al. A Phase 1 study of venetoclax (ABT-199 / GDC-0199) monotherapy in patients with relapsed/refractory Non- Hodgkin Lymphoma. Blood 2015;126:Abstract
5 Diffuse Large B-cell Lymphoma (BCEL) BCEL-C Institutional review comment to include gemcitabine, vinorelbine, rituximab as a second-line and subsequent therapy option for patients with DLBCL who are not candidates for highdose therapy. Based on the panel discussion, the consensus was to include gemcitabine, vinorelbine ± rituximab as a second-line and subsequent therapy option for patients with DLBCL who are not candidates for high-dose therapy. This was added with a category 3 designation. Papageorgiou ES, Tsirigotis P, Dimopoulos M, et al. Combination chemotherapy with gemcitabine and vinorelbine in the treatment of relapsed or refractory diffuse large B-cell lymphoma: a phase-ii trial by the Hellenic Cooperative Oncology Group. Eur J Hematol 2005;75: Xiros N, Economopoulos T, Valsami S, et al. Rituximab in combination with vinorelbine/gemcitabine chemotherapy in patients with primary refractory or early relapsed T cell rich B cell lymphoma. A pilot study. Leuk Res 2003;27: Müller-Beissenhirtz H, Kasper C, Nückel H, Dührsen U. Gemcitabine, vinorelbine and prednisone for refractory or relapsed aggressive lymphoma, results of a phase II single center study. Ann Hematol 2005;84: YES NO ABSTAIN ABSENT Supportive Care NHODG-B External request Submission request from Sanofi to: Under the First-line and at retreatment for hyperuricemia bullet, change wording to For inpatient treatment, one dose of rasburicase is frequently adequate. Doses of 3-6 mg are usually effective. Redosing should be individualized. Based on the of current data, the panel consensus was that the dose of rasburicase as listed in the guidelines is safe and effective. Therefore, the panel voted that the information regarding rasburicase dose should remain the same. YES NO ABSTAIN ABSENT
6 Add additional bullet: Currently the available data evaluating the use of fixed dose rasburicase are limited to use in the inpatient setting only along with careful and frequent monitoring. For outpatient use, where monitoring is limited or insufficient, the labeled weight-based dose of 0.2 mg/kg of rasburicase may be more appropriate, as well as the use of multiple rasburicase doses.
Panel Discussion/References
Follicular Lymphoma (FOLL) FOLL-B category designation for first-line therapy options for FL: Bendamustine + rituximab RCHOP RCVP Submission from Genentech to review the data related to obinutuzumab for
More informationNCCN Guidelines for B-Cell Lymphomas V Update Meeting 08/14/18
DIAG-1 Submission request from Adaptive Biotechnologies to add NGS as an additional option to PCR for assessing IGH and TCR gene rearrangements under Essential Diagnosis: (immunohistochemistry, flow cytometry,
More informationNCCN Non Hodgkin s Lymphomas Guidelines V Update Meeting 06/14/12 and 06/15/12
NCCN Non Hodgkin s Lymphomas Guidelines V.1.213 Update Meeting 6/14/12 and 6/15/12 Guidelines Page and Request Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma (CLL/SLL) Panel Discussion References
More informationBendamustine, Bortezomib and Rituximab in Patients with Relapsed/Refractory Indolent and Mantle-Cell Non-Hodgkin Lymphoma
Bendamustine, Bortezomib and Rituximab in Patients with Relapsed/Refractory Indolent and Mantle-Cell Non-Hodgkin Lymphoma Friedberg JW et al. Proc ASH 2009;Abstract 924. Introduction > Bendamustine (B)
More informationNotification to Implement Issued by pcodr: December 14, 2012
PROVINCIAL FUNDING SUMMARY Bendamustine hydrochloride (Treanda) for indolent Non-Hodgkin Lymphoma and Mantle Cell Lymphoma (first-line and relapsed/refractory) perc Recommendation: Recommends For further
More informationNew Targets and Treatments for Follicular Lymphoma
Winship Cancer Institute of Emory University New Targets and Treatments for Follicular Lymphoma Jonathon B. Cohen, MD, MS Assistant Professor Div of BMT, Emory University Intro/Outline Follicular lymphoma,
More informationPalliative Low Grade Lymphoma & Hairy Cell Leukemia Regimens. Low Grade Lymphoma
Palliative Low Grade Lymphoma & Hairy Cell Leukemia Regimens The following table lists the evidence-informed regimens (both IV and non-iv) for low grade lymphoma and Hairy Cell leukemia used in the palliative
More informationMathias J Rummel, MD, PhD
I N T E R V I E W Mathias J Rummel, MD, PhD Prof Rummel is Head of the Department of Hematology at the Hospital of the Justus-Liebig University in Gießen, Germany. Tracks 1-17 Track 1 Track 2 Track 3 Track
More informationCorporate Medical Policy
Corporate Medical Policy Monoclonal Antibodies for Non-Hodgkin Lymphoma and Acute Myeloid File Name: Origination: Last CAP Review: Next CAP Review: Last Review: monoclonal_antibodies_for_non_hodgkin_lymphoma_acute_myeloid_leukemia
More informationFollicular Lymphoma 2016:
Follicular Lymphoma 2016: Evolving Management Strategies Randeep Sangha, MD Medical Oncology, Cross Cancer Institute Associate Professor, University of Alberta Edmonton, AB Disclosures I have no actual
More informationBC Cancer Protocol Summary for the Treatment of rituximabrefractory Follicular Lymphoma (FL) with obinutuzumab in combination with Bendamustine
BC Cancer Protocol Summary for the Treatment of rituximabrefractory Follicular Lymphoma (FL) with obinutuzumab in combination with Bendamustine Protocol Code Tumour Group Contact Physician ULYOBBEND Lymphoma
More informationJonathan W Friedberg, MD, MMSc
I N T E R V I E W Jonathan W Friedberg, MD, MMSc Dr Friedberg is Professor of Medicine and Oncology and Chief of the Hematology/Oncology Division at the University of Rochester s James P Wilmot Cancer
More informationBendamustine is Effective Therapy in Patients with Rituximab-Refractory, Indolent B-Cell Non-Hodgkin Lymphoma
Bendamustine is Effective Therapy in Patients with Rituximab-Refractory, Indolent B-Cell Non-Hodgkin Lymphoma Kahl BS et al. Cancer 2010;116(1):106-14. Introduction > Bendamustine is a novel alkylating
More informationRecent Advances in the Treatment of Non-Hodgkin s Lymphomas
671 Highlights of the NCCN 18th Annual Conference Recent Advances in the Treatment of Presented by Jeremy S. Abramson, MD, and Andrew D. Zelenetz, MD, PhD Abstract Non-Hodgkin s lymphomas (NHL) represent
More informationRoche to present new clinical data across a variety of blood diseases at American Society of Hematology 2015 Annual Meeting
Media Release Basel, 5 November 2015 Roche to present new clinical data across a variety of blood diseases at American Society of Hematology 2015 Annual Meeting Gazyva/Gazyvaro (obinutuzumab) and investigational
More informationBrad S Kahl, MD. Tracks 1-21
I N T E R V I E W Brad S Kahl, MD Dr Kahl is Associate Professor and Director of the Lymphoma Service at the University of Wisconsin School of Medicine and Public Health and Associate Director for Clinical
More informationNew Evidence reports on presentations given at EHA/ICML Bendamustine in the Treatment of Lymphoproliferative Disorders
New Evidence reports on presentations given at EHA/ICML 2011 Bendamustine in the Treatment of Lymphoproliferative Disorders Report on EHA/ICML 2011 presentations Efficacy and safety of bendamustine plus
More informationEmerging targeted therapies for follicular lymphoma A future without chemotherapy
Emerging targeted therapies for follicular lymphoma A future without chemotherapy Pier Luigi Zinzani Institute of Hematology L. e A. Seràgnoli University of Bologna FOLLICULAR LYMPHOMA: GENERAL ASPECTS
More informationStrategies for the Treatment of Elderly DLBCL Patients, New Combination Therapy in NHL, and Maintenance Rituximab Therapy in FL
New Evidence reports on presentations given at ASH 2009 Strategies for the Treatment of Elderly DLBCL Patients, New Combination Therapy in NHL, and Maintenance Rituximab Therapy in FL From ASH 2009: Non-Hodgkin
More informationManaging patients with relapsed follicular lymphoma. Case
Managing patients with relapsed follicular lymphoma John P. Leonard, M.D. Richard T. Silver Distinguished Professor of Hematology and Medical Oncology Professor of Medicine Associate Director, Weill Cornell
More informationPatterns of Care in Medical Oncology. Follicular Lymphoma
Patterns of Care in Medical Oncology Follicular Lymphoma CASE 1: A 72-year-old man with multiple comorbidities including COPD/asthma presents with slowly progressive cervical adenopathy. Bone marrow biopsy
More informationDiffuse Large B-Cell Lymphoma (DLBCL)
Diffuse Large B-Cell Lymphoma (DLBCL) DLBCL/MCL Dr. Anthea Peters, MD, FRCPC University of Alberta/Cross Cancer Institute Disclosures Honoraria from Janssen, Abbvie, Roche, Lundbeck, Seattle Genetics Objectives
More informationVelcade (bortezomib)
Velcade (bortezomib) Line(s) of Business: HMO; PPO; QUEST Integration Medicare Advantage Original Effective Date: 03/09/2004 Current Effective Date: 03/01/2018 POLICY A. INDICATIONS The indications below
More informationGazyva (obinutuzumab)
STRENGTH DOSAGE FORM ROUTE GPID 1000mg/40mL Vial Intravenous 35532 MANUFACTURER Genentech, Inc. INDICATION(S) Gazyva (obinutuzumab) is a CD20- directed cytolytic antibody and is indicated, in combination
More informationTRANSPARENCY COMMITTEE OPINION. 27 January 2010
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 27 January 2010 TORISEL 25 mg/ml, concentrate for solution and diluent for solution for infusion Box containing 1
More informationManejo del linfoma de células del manto en la era de las terapias diana
Manejo del linfoma de células del manto en la era de las terapias diana Management of mantle cell lymphoma in the era of targeted drugs LINFOMA DE CÉLULAS DEL MANTO Robak T Department of Hematology, Medical
More informationRituxan Hycela. Rituxan Hycela (rituximab and hyaluronidase human) Description
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.21.96 Subject: Rituxan Hycela Page: 1 of 5 Last Review Date: September 15, 2017 Rituxan Hycela Description
More informationBendamustine: A Transversal * Chemotherapy Agent
Bendamustine: A Transversal * Chemotherapy Agent Bruce D. Cheson, M.D. Georgetown University Hospital Lombardi Comprehensive Cancer Center Washington, D.C., USA *Def Cutting across two lines, intersecting
More informationBortezomib (Velcade)
Bortezomib (Velcade) Policy Number: Original Effective Date: MM.04.003 03/09/2004 Line(s) of Business: Current Effective Date: HMO; PPO; QUEST Integration 06/01/2015 Section: Prescription Drugs Place(s)
More informationClinical Commissioning Policy: Bendamustine with rituximab for relapsed and refractory mantle cell lymphoma (all ages)
Clinical Commissioning Policy: Bendamustine with rituximab for relapsed and refractory mantle cell lymphoma (all ages) NHS England Reference: 170029P 1 NHS England INFORMATION READER BOX Directorate Medical
More informationMantle cell lymphoma An update on management
Mantle cell lymphoma An update on management Dr Kim Linton Consultant Medical Oncologist The Christie NHS Foundation Trust 6 th October 2016 This educational meeting is organised and sponsored by Janssen-Cilag
More informationFOLLICULAR LYMPHOMA: US vs. Europe: different approach on first relapse setting?
Indolent Lymphoma Workshop Bologna, Royal Hotel Carlton May 2017 FOLLICULAR LYMPHOMA: US vs. Europe: different approach on first relapse setting? Armando López-Guillermo Department of Hematology, Hospital
More informationBendamustine and rituximab for the treatment of relapsed indolent and mantle cell lymphoma: when timing of a study matters
Commentary Bendamustine and rituximab for the treatment of relapsed indolent and mantle cell lymphoma: when timing of a study matters Lorenzo Falchi 1, Rita Morales 1, Marco Ruella 2,3,4 1 Division of
More informationVelcade (bortezomib)
Velcade (bortezomib) Line(s) of Business: HMO; PPO; QUEST Integration Akamai Advantage Original Effective Date: 03/09/2004 Current Effective Date: 05/01/2017 POLICY A. INDICATIONS The indications below
More informationOncology Grand Rounds Series:
Oncology Grand Rounds Series: Part 6 Lymphomas and Chronic Lymphocytic Leukemia CNE Information TARGET AUDIENCE This activity has been designed to meet the educational needs of oncology nurses, nurse practitioners
More informationChronic Lymphocytic Leukemia Update. Learning Objectives
Chronic Lymphocytic Leukemia Update Ashley Morris Engemann, PharmD, BCOP, CPP Clinical Associate Adult Stem Cell Transplant Program Duke University Medical Center August 8, 2015 Learning Objectives Recommend
More informationChallenges in the Treatment of Follicular Lymphoma
Challenges in the Treatment of Follicular Lymphoma Prof. Michele Ghielmini Clinical Director Oncology Institute of Southern Switzerland Bellinzona ESMO guidelines 2014 (simplified) Low tumor burden High
More informationBendamustine s Emerging Role in the Management of Lymphoid Malignancies
Bendamustine s Emerging Role in the Management of Lymphoid Malignancies Mathias J. Rummel a and Stephanie A. Gregory b The potent alkylating agent bendamustine has demonstrated substantial efficacy in
More informationpan-canadian Oncology Drug Review Final Clinical Guidance Report Idelalisib (Zydelig) for Follicular Lymphoma September 29, 2016
pan-canadian Oncology Drug Review Final Clinical Guidance Report Idelalisib (Zydelig) for Follicular Lymphoma September 29, 2016 DISCLAIMER Not a Substitute for Professional Advice This report is primarily
More informationCARE at ASH 2014 Lymphoma. Dr. Diego Villa Medical Oncologist British Columbia Cancer Agency Vancouver Cancer Centre
CARE at ASH 2014 Lymphoma Dr. Diego Villa Medical Oncologist British Columbia Cancer Agency Vancouver Cancer Centre High-yield lymphoma sessions Sat, Dec 6 th Sun, Dec 7 th Mon, Dec 8 th EDUCATIONAL SESSIONS
More informationUpdate: Non-Hodgkin s Lymphoma
2008 Update: Non-Hodgkin s Lymphoma ICML 2008: Update on non-hodgkin s lymphoma Diffuse Large B-cell Lymphoma Improved outcome of elderly patients with poor-prognosis diffuse large B-cell lymphoma (DLBCL)
More informationRITUXAN (rituximab and hyaluronidase human)
Drug Prior Authorization Guideline RITUXIMAB products J9310 RITUXAN (rituximab and hyaluronidase human) PA9847 Covered Service: Prior Authorization Required: Additional Information: Yes when meets criteria
More informationGLSG/OSHO Study Group. Supported by Deutsche Krebshilfe
GLSG/OSHO Study Group Supported by Deutsche Krebshilfe founded in 1985 Comparison of Two Consecutive Study Generations of the GLSG Overall Survival Follicular Lymphomas Questions for the Next Steps of
More informationObinutuzumab in combination with bendamustine for treating rituximab-refractory follicular lymphoma
Obinutuzumab in combination with bendamustine for treating rituximab-refractory follicular lymphoma 1 st Appraisal Committee meeting Background and Clinical Effectiveness Committee A Lead team John Watkins
More informationNational Institute for Health and Clinical Excellence. Single Technology Appraisal (STA)
National Institute for Health and Clinical Excellence Summary form Single Technology Appraisal (STA) Pixantrone monotherapy for the treatment of relapsed or refractory Response to consultee and commentator
More informationLymphoma 101. Nathalie Johnson, MDPhD. Division of Hematology Jewish General Hospital Associate Professor of Medicine, McGill University
Lymphoma 101 Nathalie Johnson, MDPhD Division of Hematology Jewish General Hospital Associate Professor of Medicine, McGill University Disclosures Consultant and Advisory boards for multiple companies
More informationThe role of rituximab for maintenance therapy in
COUNTERPOINTS Current Controversies in Hematology and Oncology Counterpoints Is Maintenance Therapy Necessary in Low-Grade Lymphoma? Maintenance therapy with rituximab has been shown to prolong progression-free
More informationYESCARTA (axicabtagene ciloleucel)
YESCARTA (axicabtagene ciloleucel) Non-Discrimination Statement and Multi-Language Interpreter Services information are located at the end of this document. Coverage for services, procedures, medical devices
More informationGazyva (obinutuzumab)
Gazyva (obinutuzumab) Line(s) of Business: HMO; PPO; QUEST Integration Medicare Advantage Original Effective Date: 10/01/2015 Current Effective Date: 01/01/201807/01/2018 POLICY A. INDICATIONS The indications
More informationClinical Commissioning Policy: Bendamustine with rituximab for relapsed and refractory mantle cell lymphoma (all ages) NHS England Reference: P
Clinical Commissioning Policy: Bendamustine with rituximab for relapsed and refractory mantle cell lymphoma (all ages) NHS England Reference: 170054P 1 NHS England INFORMATION READER BOX Directorate Medical
More informationTreatment Nodal Marginal Zone Lymphoma
Workshop : Indolent lymphomas Treatment Nodal Marginal Zone Lymphoma Catherine Thieblemont Hôpital Saint-Louis, Paris - France Bologna 16th, 2017 Ø No standardized treatment Ø Similarly treated as FL Treatment
More informationHow to incorporate new therapies into the treatment algorithm of patients with mantle cell lymphoma
How to incorporate new therapies into the treatment algorithm of patients with mantle cell lymphoma Dr. Guillermo Rodríguez García Hospital Universitario Virgen Macarena Hospital Universitario Virgen del
More informationClinical Roundtable Monograph
Clinical Roundtable Monograph Clinical Advances in Hematology & Oncology December 2013 Integrating Emerging Treatment Options in Mantle Cell Lymphoma Moderator Discussants Brad S. Kahl, MD Skoronski Chair
More informationNHS England. Evidence review: Bendamustine-based chemotherapy for treatment of relapsed or refractory Mantle Cell Lymphoma (MCL)
NHS England Evidence review: Bendamustine-based chemotherapy for treatment of relapsed or refractory Mantle Cell Lymphoma (MCL) 1 NHS England Evidence review: Bendamustine-based chemotherapy for treatment
More informationLymphoma Christophe BONNET Centre Hospitalier Universitaire, Ulg, Liège. 14 th post-ash meeting, January 6 th 2011, Brussels
Lymphoma Christophe BONNET Centre Hospitalier Universitaire, Ulg, Liège 14 th post-ash meeting, January 6 th 2011, Brussels Hodgkin s lymphoma Follicular lymphoma Diffuse large B-cell lymphoma Mantle cell
More informationLow grade Non-Hodgkin Lymphoma: New Therapies & Updates
Low grade Non-Hodgkin Lymphoma: New Therapies & Updates Craig A. Portell MD Assistant Professor of Medicine ivision of Hematology/Oncology University of Virginia Friday, April 28, 2017 Disclosures I have
More informationExpert Perspective on ASH 2014: Lymphoma
Expert Perspective on ASH 2014: Lymphoma Myron S. Czuczman, MD Abstract The 2014 Annual Meeting and Exposition of the American Society of Hematology included many updates of previously presented studies,
More informationBTK Inhibitors and BCL2 Antagonists
BTK Inhibitors and BCL2 Antagonists Constantine (Con) S. Tam Director of Haematology, St Vincent s Hospital Melbourne; Lead for Chronic Lymphocytic Leukemia and Indolent Lymphoma, Peter MacCallum Cancer
More informationSEQUENCING FOLLICULAR LYMPHOMA
SEQUENCING FOLLICULAR LYMPHOMA Thomas E. Witzig, MD October 24, 2015 Disclosures All presenters were independently selected by the organizing committee. Those presenters who disclosed affiliations or financial
More informationWaldenstrom s Macroglobulinemia
Waldenstrom s Macroglobulinemia : Introduction Waldenstrom s macroglobulinemia (WM) is a lymphoma, or cancer of the lymphatic system. It occurs in a type of white blood cell called a B-lymphocyte or B-cell,
More informationThe case against maintenance rituximab in Follicular lymphoma. Jonathan W. Friedberg M.D., M.M.Sc.
The case against maintenance rituximab in Follicular lymphoma Jonathan W. Friedberg M.D., M.M.Sc. Follicular lymphoma: What are goals of treatment? Change natural history of disease: Decrease transformation
More informationOSCO/OU ASH-SABC Review. Lymphoma Update. Mohamad Cherry, MD
OSCO/OU ASH-SABC Review Lymphoma Update Mohamad Cherry, MD Outline Diffuse Large B Cell Lymphoma Double Hit Lymphoma Follicular and Indolent B Cell Lymphomas Mantle Cell Lymphoma T Cell Lymphoma Hodgkin
More informationRituximab in Lymphoma and Chronic Lymphocytic Leukemia: A Clinical Practice Guideline, Version 3
A Quality Initiative of the Program in Evidence-based Care (PEBC), Cancer Care Ontario (CCO) Rituximab in Lymphoma and Chronic Lymphocytic Leukemia: A Clinical Practice Guideline, Version 3 A. Prica, F.
More informationInitial Recommendation for Ibrutinib (Imbruvica) for Mantle Cell Lymphoma perc Meeting: June 16, pcodr PAN-CANADIAN ONCOLOGY DRUG REVIEW 4
although ibrutinib was associated with significant improvements in PFS and QoL, adverse events such as fatigue and bleeding were still observed in patients who received ibrutinib. perc concluded that overall,
More informationCLINICAL MEDICAL POLICY
CLINICAL MEDICAL POLICY Policy Name: Rituxan (rituximab) Policy Number: MP-031-MD-DE Responsible Department(s): Medical Management; Clinical Pharmacy Provider Notice Date: 10/01/2017 Issue Date: 11/01/2017
More informationMantle Cell Lymphoma: Update in Diego Villa, MD MPH FRCPC Medical Oncologist BC Cancer Agency
Mantle Cell Lymphoma: Update in 2015 Diego Villa, MD MPH FRCPC Medical Oncologist BC Cancer Agency Disclosures Research funding: Roche provides research funding to support the Centre for Lymphoid Cancer
More informationRituximab in the Treatment of NHL:
New Evidence reports on presentations given at ASH 2010 Rituximab in the Treatment of NHL: Rituximab versus Watch and Wait in Asymptomatic FL, R-Maintenance Therapy in FL with Standard or Rapid Infusion,
More informationAPPLICATION FOR SUBSIDY BY SPECIAL AUTHORITY
Page 1 Rituximab INITIAL APPLICATION - Post-transplant The patient has B-cell post-transplant lymphoproliferative disder* To be used f a maximum of 8 treatment cycles Indications marked with * are Unapproved
More informationpan-canadian Oncology Drug Review Initial Economic Guidance Report Obinutuzumab (Gazyva) for Follicular Lymphoma August 30, 2018
pan-canadian Oncology Drug Review Initial Economic Guidance Report Obinutuzumab (Gazyva) for Follicular Lymphoma August 30, 2018 DISCLAIMER Not a Substitute for Professional Advice This report is primarily
More informationPOST ICML Indolent lymphomas relapse treatment
POST ICML Indolent lymphomas relapse treatment Georg Hess University Medical School Johannes Gutenberg-University Mainz, Germany Treatment of relapsed indolent lymphoma 2 General categories of second line
More informationThe legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 18 July 2012
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 18 July 2012 MABTHERA 100 mg, concentrate for solution for infusion B/2 (CIP code: 560 600-3) MABTHERA 500 mg, concentrate
More informationCHMP recommends EU approval of Roche s Gazyvaro for people with previously treated follicular lymphoma
Media Release Basel, 29 April 2016 CHMP recommends EU approval of Roche s Gazyvaro for people with previously treated follicular lymphoma In the pivotal study, treatment with Gazyvaro plus bendamustine
More informationAntibody-Based Immunotherapeutic Agents for Treatment of Non-Hodgkin Lymphoma
Antibody-Based Immunotherapeutic Agents for Treatment of Non-Hodgkin Lymphoma Steven I. Park, MD, 1* and Kristy L. Richards, PhD, MD 1 ABSTRACT Antibody-based immunotherapeutic agents have emerged as important
More informationIdelalisib treatment is associated with improved cytopenias in patients with relapsed/refractory inhl and CLL
Idelalisib treatment is associated with improved cytopenias in patients with relapsed/refractory inhl and CLL Susan M O Brien, Andrew J Davies, Ian W Flinn, Ajay K Gopal, Thomas J Kipps, Gilles A Salles,
More informationMedication Policy Manual. Topic: Arzerra, ofatumumab Date of Origin: January 15, 2010
Independent licensees of the Blue Cross and Blue Shield Association Medication Policy Manual Policy No: dru196 Topic: Arzerra, ofatumumab Date of Origin: January 15, 2010 Committee Approval Date: January
More informationIs there a role of HDT ASCT as consolidation therapy for first relapse follicular lymphoma in the post Rituximab era? Yes
Is there a role of HDT ASCT as consolidation therapy for first relapse follicular lymphoma in the post Rituximab era? Yes Bertrand Coiffier Service d Hématologie Hospices Civils de Lyon Equipe «Pathologie
More informationHigh Grade Lymphoma. Trial name & Treatment Key entry criteria Open Sites. Relapsed/Refractory
DISEASE or High Grade Lymphoma DLBCL INCA = Inotuzumab Ozogamicin (INO) + Rituximab + CVP v Gemcitabine + Rituximab + CVP following a steroid pre-phase of pred 60mg x 7 days Second Line Trial name & Treatment
More informationBcl-2 inhibition in NHL. Jonathan W. Friedberg M.D., M.M.Sc.
Bcl-2 inhibition in NHL Jonathan W. Friedberg M.D., M.M.Sc. BCL-2, BH3 and apoptosis: Rational therapeutic targets in NHL Antiapoptotic proteins, prevent activation of Bax and Bak, thus inhibiting apoptosis.
More informationSHIFTING TREATMENT PARADIGMS IN NON-HODGKIN LYMPHOMAS
SHIFTING TREATMENT PARADIGMS IN NON-HODGKIN LYMPHOMAS This symposium took place on 22 nd June 2017, as part of the 22 nd Congress of the European Hematology Association (EHA) in Madrid, Spain Chairperson
More informationNon-Hodgkin s Lymphomas Version
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) Non-Hodgkin s Lymphomas Version 2.2015 NCCN.org Continue Version 2.2015, 03/03/15 National Comprehensive Cancer Network, Inc. 2015, All
More informationClinical Policy: Obinutuzumab (Gazyva) Reference Number: CP.PHAR.305 Effective Date: Last Review Date: Line of Business: Medicaid
Clinical Policy: (Gazyva) Reference Number: CP.PHAR.305 Effective Date: 02.01.17 Last Review Date: 11.17 Line of Business: Medicaid Coding Implications Revision Log See Important Reminder at the end of
More informationNCCN Non-Hodgkin s Lymphomas Guidelines V Update Meeting 06/14/10 and 06/15/10
NCCN Non-Hodgkin s Lymphomas Guidelines V.1.211 Update Meeting 6/14/1 and 6/15/1 CSLL-D Submitted by sanofi-aventis for the inclusion of oral fludarabine for use in first-line CLL and in other NHL subtypes
More informationCOMPENDIA TRANSPARENCY TRACKING FORM. Gemcitabine hydrochloride. Mantle cell lymphoma, relapsed or refractory, as combination therapy
COMPENDIA TRANSPARENCY TRACKING FORM DRUG: Gemcitabine hydrochloride INDICATION: Mantle cell lymphoma, relapsed or refractory, as combination therapy COMPENDIA TRANSPARENCY REQUIREMENTS 1 Provide criteria
More informationVenous thromboembolism in patients with B-cell non-hodgkin lymphoma treated with lenalidomide: a systematic review and meta-analysis
REGULAR ARTICLE Venous thromboembolism in patients with B-cell non-hodgkin lymphoma treated with lenalidomide: a systematic review and meta-analysis Samuel Yamshon, 1 Paul J. Christos, 2 Michelle Demetres,
More informationUPDATE Autologous Stem Cell Transplantation for Lymphoma and Myeloma
UPDATE Autologous Stem Cell Transplantation for Lymphoma and Myeloma Supported by a grant from Supported by a grant from UPDATE Autologous Stem Cell Transplantation for Lymphoma and Myeloma Jonathan W.
More informationClinical Commissioning Policy Proposition: Bendamustine with rituximab for first line treatment of mantle cell lymphoma. Reference: NHS England 1630
Clinical Commissioning Policy Proposition: Bendamustine with rituximab for first line treatment of mantle cell lymphoma Reference: NHS England 1630 1 First published: TBC Prepared by NHS England Specialised
More informationManagement of high-risk diffuse large B cell lymphoma: case presentation
Management of high-risk diffuse large B cell lymphoma: case presentation Daniel J. Landsburg, MD Assistant Professor of Clinical Medicine Perelman School of Medicine University of Pennsylvania January
More informationWhat are the hurdles to using cell of origin in classification to treat DLBCL?
What are the hurdles to using cell of origin in classification to treat DLBCL? John P. Leonard, M.D. Richard T. Silver Distinguished Professor of Hematology and Medical Oncology Associate Dean for Clinical
More informationState of the art: CAR-T cell therapy in lymphoma
State of the art: CAR-T cell therapy in lymphoma 14 th annual California Cancer Consortium conference Tanya Siddiqi, MD City of Hope Medical Center 8/11/18 Financial disclosures Consultant for Juno therapeutics
More informationSee Important Reminder at the end of this policy for important regulatory and legal information.
Clinical Policy: (Venclexta) Reference Number: CP.PHAR.129 Effective Date: 07.17.18 Last Review Date: 02.19 Line of Business: Commercial, Medicaid Revision Log See Important Reminder at the end of this
More informationHodgkin and Non-Hodgkin Lymphoma (LYM) Post-Infusion Data
Hodgkin and Non-Hodgkin Lymphoma (LYM) Post-Infusion Data Registry Use Only Sequence Number: Date Received: CIBMTR Center Number: CIBMTR Research ID: Event date: / / Visit 100 day 6 months 1 year 2 years
More informationClinical Policy: Idelalisib (Zydelig) Reference Number: ERX.SPA.269 Effective Date:
Clinical Policy: (Zydelig) Reference Number: ERX.SPA.269 Effective Date: 12.01.18 Last Review Date: 11.18 Revision Log See Important Reminder at the end of this policy for important regulatory and legal
More informationMEDICAL COVERAGE GUIDELINES ORIGINAL EFFECTIVE DATE: 08/19/14 SECTION: DRUGS LAST REVIEW DATE: LAST CRITERIA REVISION DATE: ARCHIVE DATE:
RITUXAN (rituximab) Coverage for services, procedures, medical devices and drugs are dependent upon benefit eligibility as outlined in the member's specific benefit plan. This Medical Coverage Guideline
More informationOutcomes of Treatment in Slovene Follicular Lymphoma Patients
Original Study Outcomes of Treatment in Slovene Follicular Lymphoma Patients Tanja Juznic Setina, Simona Borstnar, Barbara Jezersek Novakovic Abstract The treatment outcomes of follicular lymphoma (FL)
More informationCPAG Summary Report for Clinical Panel Policy 1630 Bendamustine-based chemotherapy for first-line treatment of Mantle cell lymphoma (MCL) in adults
MANAGEMENT IN CONFIDENCE CPAG Summary Report for Clinical Panel Policy 1630 Bendamustine-based chemotherapy for first-line treatment of Mantle cell lymphoma (MCL) in adults The Benefits of the Proposition
More informationDisclosures WOJCIECH JURCZAK
Disclosures WOJCIECH JURCZAK ABBVIE (RESEARCH FUNDING), CELGENE (RESEARCH FUNDING); EISAI (RESEARCH FUNDING); GILEAD (RESEARCH FUNDING); JANSEN (RESEARCH FUNDING); MORPHOSYS (RESEARCH FUNDING), MUNDIPHARMA
More informationMantle Cell Lymphoma. A schizophrenic disease
23 maggio, 2018 Mantle Cell Lymphoma A schizophrenic disease Patients relapsed after Auto transplant EBMT registry 2000-2009 (n=360) 19 months OS 24 months OS Dietrich S, Ann Oncol 2014 Patients receiving
More informationCost-effectiveness of Obinutuzumab (Gazyvaro ) for the Treatment of Follicular Lymphoma
Cost-effectiveness of Obinutuzumab (Gazyvaro ) for the Treatment of Follicular Lymphoma The NCPE has issued a recommendation regarding the cost-effectiveness of obinutuzumab (Gazyvaro ). Following NCPE
More informationBendamustine for relapsed follicular lymphoma refractory to rituximab
LONDON CANCER NEW DRUGS GROUP RAPID REVIEW Bendamustine for relapsed follicular lymphoma refractory to rituximab Bendamustine for relapsed follicular lymphoma refractory to rituximab Contents Summary 1
More information2018 KSMO Immune Oncology Forum. Immune checkpoint inhibitors in hematologic. malignancies: evidences and perspectives 서울아산병원종양내과 홍정용
2018 KSMO Immune Oncology Forum Immune checkpoint inhibitors in hematologic malignancies: evidences and perspectives 서울아산병원종양내과 홍정용 2018-07-18 Contents Introduction Immune checkpoint inhibtors in lymphomas
More information