Frozen Section Library: Pleura
|
|
- Dwayne Chester Jackson
- 5 years ago
- Views:
Transcription
1
2 Frozen Section Library: Pleura For other titles published in this series, go to
3 Frozen Section Library: Pleura Philip T. Cagle, MD Weill Medical College of Cornell University, NY, NY The Methodist Hospital, Houston, TX, USA Timothy Craig Allen, MD, JD University of Texas Health Science Center at Tyler, Tyler, TX, USA
4 Dr. Philip T. Cagle Weill Medical College of Cornell University The Methodist Hospital Houston, TX USA Dr. Timothy Craig Allen University of Texas Health Science Center at Tyler Tyler, TX USA ISSN e-issn ISBN e-isbn DOI / Springer New York Dordrecht Heidelberg London Library of Congress Control Number: Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (
5 To my wife, Kirsten Philip T. Cagle To my parents, Oliver and Mildred Allen Timothy Craig Allen
6 Series Preface For over 100 years, the frozen section has been utilized as a tool for the rapid diagnosis of specimens while a patient is undergoing surgery, usually under general anesthesia, as a basis for making immediate treatment decisions. Frozen section diagnosis is often a challenge for the pathologist who must render a diagnosis that has crucial import for the patient in a minimal amount of time. In addition to the need for rapid recall of differential diagnoses, there are many pitfalls and artifacts that add to the risk of frozen section diagnosis that are not present with permanent sections of fully processed tissues that can be examined in a more leisurely fashion. Despite the century-long utilization of frozen sections, most standard pathology textbooks, both general and subspecialty, largely ignore the topic of frozen sections. Few textbooks have ever focused exclusively on frozen section diagnosis, and those textbooks that have done so are now out-of-date and have limited illustrations. The Frozen Section Library series is meant to provide convenient, user-friendly handbooks for each organ system to expedite use in the rushed frozen section situation. These books are small and lightweight, copiously color illustrated with images of actual frozen sections, highlighting pitfalls, artifacts, and differential diagnosis. The advantages of a series of organ-specific handbooks, in addition to the ease of use and manageable size, are that (1) a series allows more comprehensive coverage of more diagnoses, both common and rare, than a single volume that tries to highlight a limited number of diagnoses for each organ and (2) a series allows more detailed insight by permitting experienced authorities to emphasize the peculiarities of frozen section for each organ system. As a handbook for practicing pathologists, these books will be indispensable aids to diagnosis and avoiding dangers in one of the most challenging situations that pathologists encounter. Rapid consideration of differential diagnoses and how to avoid traps caused by frozen section artifacts are emphasized in these vii
7 viii Series Preface handbooks. A series of concise, easy-to-use, well-illustrated handbooks alleviates the often frustrating and time-consuming, sometimes futile, process of searching through bulky textbooks that are unlikely to illustrate or discuss pathologic diagnoses from the perspective of frozen sections in the first place. Tables and charts will provide guidance for differential diagnosis of various histologic patterns. Touch preparations, which are used for some organs such as central nervous system or thyroid more often than others, are appropriately emphasized and illustrated according to the need for each specific organ. This series is meant to benefit practicing surgical pathologists, both community and academic, and pathology residents and fellows and also to provide valuable perspectives to surgeons, surgery residents, and fellows who must rely on frozen section diagnosis by their pathologists. Most of all, we hope that this series contributes to the improved care of patients who rely on the frozen section to help guide their treatment. Houston, TX Philip T. Cagle Series Editor
8 Preface Frozen sections are diagnosed by the pathologist while a patient is undergoing surgery, often under general anesthesia, for the purpose of rapid diagnosis, which may be used to make immediate treatment decisions or to confirm that diagnostic tissues have been sampled for further study. As a result, frozen section diagnosis is often a highly demanding situation for the pathologist who must render a diagnosis quickly and is a basis for critical decisions to the surgeon. In addition to the need for rapid recall of differential diagnoses, there are many pitfalls and artifacts that add to the risk of frozen section diagnosis that are not present with permanent sections of fully processed tissues that can be examined in a more leisurely fashion. Most standard pathology textbooks, both general and subspecialty, largely ignore the topic of frozen section. Few textbooks have ever focused exclusively on frozen section diagnosis. The Frozen Section of the Pleura provides a convenient, userfriendly handbook to expedite use when performing intraoperative consultations on pleural specimens. This book is divided into chapters that emphasize the common questions that a pathologist must answer on frozen section examination and the pitfalls associated with those specific diagnoses. The diagnostic issues impacting immediate surgical decision-making are color illustrated and discussed succinctly, including a complex array of primary and secondary neoplasms of the pleura that have overlapping histologic features and the well-known problems of reactive atypia vs. cancer in pleural tissue. As a handbook for practicing pathologists, this book is an indispensible aid to diagnosis and avoiding dangers in one of the most challenging situations that pathologists encounter. Rapid consideration of differential diagnoses and how to avoid traps caused by frozen section artifacts will be readily accessible to the users of this handbook. Tables provide guidance for various categories of differential diagnoses. Currently, there is no other ix
9 x Preface up-to-date single-source reference specifically focused on frozen sections of the pleura. This book will be highly valuable to practicing surgical pathologists, both community and academic, and to pathology residents and fellows. The perspectives provided will also be valuable to thoracic surgeons and especially to surgery residents and thoracic surgery fellows who must answer questions about pathology and frozen section on their board examinations. Tyler, TX Houston, TX Timothy Craig Allen Philip T. Cagle
10 Contents Preface... ix 1. Diffuse Malignant Mesothelioma... 1 Introduction... 1 Diffuse Malignant Mesothelioma Metastatic Cancers Other Primary Neoplasms of the Pleura Pleuritis and Pleural Plaque Uncommon Nonneoplastic Lesions of the Pleura Benign Reactive Proliferations vs. Malignancy Suggested Reading Index xi
11 Chapter 1 Diffuse Malignant Mesothelioma INTRODUCTION Frozen section of pleural tissue is performed during surgery to confirm that diagnostic tissue has been obtained for permanent section examination and to decide on intraoperative therapy. Benign reactive/inflammatory conditions (infections, plaques, pleuritis of various etiologies), benign neoplasms, primary pleural malignancies, and metastatic cancers may produce overlapping radiologic, clinical, or gross findings. These diverse pleural diseases (1) may cause pleural thickening, nodules or masses observed on imaging studies or grossly by the surgeon, (2) are often accompanied by pleural effusions, and (3) may be asymptomatic or cause difficulty in breathing, chest pain, or other thoracic symptoms, regardless of the etiology. The suspected diagnosis based on clinical context and current imaging modalities often proves correct. However, even the most recent advances in noninvasive diagnosis have limitations. For example, a few cases of malignancy will be negative on positron emission tomography (PET) using 18-fluorodeoxyglucose (FDG), and some benign reactive/inflammatory conditions will be positive. Even when a diagnosis of cancer is correctly rendered on a clinical and radiologic basis, histologic examination may be necessary to determine the type of malignancy involving the pleura. Therefore, even with modern imaging techniques, t he definitive diagnosis of a pleural abnormality often requires tissue samples. Although pleural effusion cytology and transthoracic needle biopsy may provide an accurate diagnosis of a pleural abnormality, larger or more representative tissue samples may be necessary to render a diagnosis in some cases. Frozen section allows the pathologist to guide the surgeon in obtaining adequate samples 1 P.T. Cagle and T.C. Allen, Frozen Section Library: Pleura, Frozen Section Library 3, DOI / _1, Springer Science + Business Media, LLC 2010
12 2 Frozen Section Library: PLEURA for diagnosis on permanent section and also provides the surgeon with immediate feedback for intraoperative therapeutic decisions. Therapy at the time of surgery depends in large part on the diagnosis rendered at frozen section: (1) often no additional therapy for reactive/inflammatory conditions (samples may be taken for additional studies such as permanent sections, microbiologic cultures, etc), (2) complete resection for benign neoplasms, localized malignant neoplasms, and solitary metastases, and (3) pleurodesis, pleurectomy, decortication, or possibly more extensive resection for cancer. On occasion, frozen section of the pleura may also be performed for margins of a pleuropneumonectomy/extrapleural pneumonectomy. DIFFUSE MALIGNANT MESOTHELIOMA Although it is the most common primary neoplasm of the pleura, diffuse malignant mesothelioma (DMM) is relatively rare compared with most cancers with about 2,000 new cases in the USA each year. Because of its extremely bleak prognosis with limited treatment options and the potential for compensation to the patient in toxic tort litigation, accurate diagnosis of DMM has great importance despite its comparative uncommonness. There are two primary categories of differential diagnoses for DMM. The first category of differential diagnoses is DMM vs. other types of cancer involving the pleura. The latter includes primary pleural cancers other than DMM and, more commonly, cancers metastatic to the pleura. The histologic features of these differential diagnoses are further discussed in Chaps. 2 and 3. The second category of differential diagnoses is DMM vs. benign reactive/ inflammatory processes that produce mesothelial hyperplasia or granulation tissue that mimics DMM. The problem of distinguishing benign reactive proliferations from malignancy, particularly DMM, is discussed in detail in Chap. 6. DMM arises from mesothelial cells and often spreads as diffuse nodules over serosal membrane surfaces, classically encasing the lung along the pleural surface. DMM may invade or metastasize into underlying or neighboring tissues and sometimes form bulky masses, but their gross distribution along serosal membrane surfaces is an essential feature of their diagnosis. The gross description of the surgeon and the radiologic findings to confirm the characteristic growth patterns of DMM are very important to the diagnosis of DMM. However, metastatic cancers and other primary cancers of the pleura may grow in patterns that mimic the growth pattern of DMM and, therefore, serosal surface distribution by itself is not diagnostic of DMM. Essentially always, the definitive diagnosis of DMM depends on examination of permanent tissue sections, often accompanied
Frozen Section Library: Lung
Frozen Section Library: Lung FROZEN SECTION LIBRARY SERIES Philip T. Cagle, MD, Series Editor 1. Timothy Craig Allen, Philip T. Cagle: Frozen Section Library: Lung 2009 ISBN 978-0-387-09572-1 Frozen Section
More informationFrozen Section Library Series Editor Philip T. Cagle, MD Houston, Texas, USA
Frozen Section Library Series Editor Philip T. Cagle, MD Houston, Texas, USA For further volumes, go to http://www.springer.com/series/7869 Frozen Section Library: Central Nervous System Richard A. Prayson
More informationAlexander N. Sencha Elena V. Evseeva Mikhail S. Mogutov Yury N. Patrunov. Breast Ultrasound
Breast Ultrasound Alexander N. Sencha Elena V. Evseeva Mikhail S. Mogutov Yury N. Patrunov Breast Ultrasound Alexander N. Sencha Department of Ultrasound Diagnostics Yaroslavl Railway Clinic Yaroslavl
More informationMaurie Markman, MD, Series Editor
Palliative Care Current Clinical Oncology Maurie Markman, MD, Series Editor For other titles published in this series, go to www.springer.com/series/7631 Palliative Care A Ca s e-b a s e d Gu i d e Edited
More informationChronic Pain. For other titles published in this series, go to
Chronic Pain For other titles published in this series, go to www.springer.com/series/7633 Dawn A. Marcus, M.D. Chronic Pain A Primary Care Guide to Practical Management Second Edition Dawn A. Marcus,
More informationEssentials in Cytopathology Series
Essentials in Cytopathology Series ESSENTIALS IN CYTOPATHOLOGY SERIES Dorothy L. Rosenthal, MD, FIAC, Series Editor 1. D.P. Clark and W.C. Faquin: Thyroid Cytopathology. 2005 ISBN 0-387-23304-0 Douglas
More informationCytology and Surgical Pathology of Gynecologic Neoplasms
Cytology and Surgical Pathology of Gynecologic Neoplasms Current Clinical Pathology ANTONIO GIORDANO, MD, PHD SERIES EDITOR For further titles published in this series, go to http://www.springer.com/springer/series/7632
More informationSpringerBriefs in Child Development
SpringerBriefs in Child Development For further volumes: http://www.springer.com/series/10210 Daniel F. Shreeve Reactive Attachment Disorder A Case-Based Approach Daniel F. Shreeve The Carilion Clinic
More informationAtlas of Lymph Node Anatomy
Atlas of Lymph Node Anatomy Mukesh G. Harisinghani Editor Atlas of Lymph Node Anatomy This publication was developed through an unrestricted educational grant from Siemens. Editor Mukesh G. Harisinghani
More informationECG INTERPRETATION: FROM PATHOPHYSIOLOGY TO CLINICAL APPLICATION
ECG INTERPRETATION: FROM PATHOPHYSIOLOGY TO CLINICAL APPLICATION ECG INTERPRETATION: FROM PATHOPHYSIOLOGY TO CLINICAL APPLICATION by Fred Kusumoto, MD Electrophysiology and Pacing Service Division of Cardiovascular
More informationThe Pharmacology of Alcohol and Drugs of Abuse and Addiction
The Pharmacology of Alcohol and Drugs of Abuse and Addiction Norman S. Miller The Pharmacology of Alcohol and Drugs of Abuse and Addiction Springer-Verlag New York Berlin Heidelberg London Paris Tokyo
More informationSPRINGER BRIEFS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. Gerhard Bauer Joseph S. Anderson. Gene Therapy for HIV From Inception to a Possible Cure
SPRINGER BRIEFS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY Gerhard Bauer Joseph S. Anderson Gene Therapy for HIV From Inception to a Possible Cure 123 SpringerBriefs in Biochemistry and Molecular Biology For
More informationCancer Treatment and Research
Cancer Treatment and Research Volume 155 Series Editor Steven T. Rosen For further volumes: http://www.springer.com/series/5808 Boris Pasche Editor Cancer Genetics 123 Editor Boris Pasche, MD, PhD, FACP
More informationHandbook of Pediatric Eye and Systemic Disease
Handbook of Pediatric Eye and Systemic Disease Handbook of Pediatric Eye and Systemic Disease Edited by Kenneth W. Wright, MD Director, Wright Foundation for Pediatric Ophthalmology Director, Pediatric
More informationHODGKIN S AND NON-HODGKIN S LYMPHOMA
HODGKIN S AND NON-HODGKIN S LYMPHOMA edited by JOHN P. LEONARD, MD Center for Lymphoma and Myeloma Weill Medical College of Cornell University New York Presbyterian Hospital New York, NY MORTON COLEMAN,
More informationRadiology Illustrated
Radiology Illustrated For further volumes: http://www.springer.com/series/11755 In-One Kim Editor Radiology Illustrated: Pediatric Radiology Editor In-One Kim, M.D. Department of Radiology Seoul National
More informationUrinary Tract Infection
Urinary Tract Infection Abhay Rané Ranan Dasgupta Editors Urinary Tract Infection Clinical Perspectives on Urinary Tract Infection Editors Abhay Rané, MS, FRCS, FRCS (Urol) Department of Urology Surrey
More informationCongenital Hip Disease in Adults
Congenital Hip Disease in Adults George Hartofilakidis George C. Babis Kalliopi Lampropoulou-Adamidou Congenital Hip Disease in Adults George Hartofilakidis, MD, FACS Orthopaedic Department Medical School
More informationDating Neurological Injury
Dating Neurological Injury wwwwwwwww Jeff L. Creasy Dating Neurological Injury A Forensic Guide for Radiologists, Other Expert Medical Witnesses, and Attorneys Jeff L. Creasy Associate Professor of Neuroradiology
More informationAMERICAN JOINT COMMITTEE ON CANCER AJCC CANCER STAGING
AMERICAN JOINT COMMITTEE ON CANCER AJCC CANCER STAGING ATLAS EDITORS FREDERICK L. GREENE, m.d. Chair, Department of General Surgery Carolinas Medical Center Charlotte, North Carolina CAROLYN C. COMPTON,
More informationDifferential Diagnosis of Movement Disorders in Clinical Practice
Differential Diagnosis of Movement Disorders in Clinical Practice Abdul Qayyum Rana Peter Hedera Differential Diagnosis of Movement Disorders in Clinical Practice Abdul Qayyum Rana Parkinson's Clinic
More informationDeath Threats and Violence
Death Threats and Violence Stephen J. Morewitz Death Threats and Violence New Research and Clinical Perspectives Stephen J. Morewitz San Francisco, California Tarzana, California Buffalo Grove, Illinois
More informationCommunication in Cognitive Behavioral Therapy
Communication in Cognitive Behavioral Therapy Michela Rimondini Editor Communication in Cognitive Behavioral Therapy Editor Michela Rimondini Department of Public Health and Community Medicine University
More informationRespiratory Medicine Series Editor: Sharon I.S. Rounds. Marc A. Judson Editor. Pulmonary Sarcoidosis A Guide for the Practicing Clinician
Respiratory Medicine Series Editor: Sharon I.S. Rounds Marc A. Judson Editor Pulmonary Sarcoidosis A Guide for the Practicing Clinician Respiratory Medicine Series Editor: Sharon I.S. Rounds For further
More informationJeffrey P. Weiss Jerry G. Blaivas Philip E.V. Van Kerrebroeck Alan J. Wein. Editors. Nocturia. Causes, Consequences and Clinical Approaches
Nocturia Jeffrey P. Weiss Jerry G. Blaivas Philip E.V. Van Kerrebroeck Alan J. Wein Editors Nocturia Causes, Consequences and Clinical Approaches Editors Jeffrey P. Weiss, MD, FACS Department of Urology
More informationPercutaneous Laser Disc Decompression
Percutaneous Laser Disc Decompression , MD Assistant Clinical Professor of Medicine, Columbia University College of Physicians & Surgeons, New York, New York; and Director of Laser Spine Center, New York,
More informationPOCKET HANDBOOK OF GI PHARMACOTHERAPEUTICS
POCKET HANDBOOK OF GI PHARMACOTHERAPEUTICS CLINICAL GASTROENTEROLOGY GEORGE Y. WU, SERIES EDITOR For other titles published in this series, go to www.springer.com/series/7672 POCKET HANDBOOK OF GI PHARMACOTHERAPEUTICS
More informationBreast Cancer Risk Reduction and Early Detection
Breast Cancer Risk Reduction and Early Detection Edward R. Sauter Mary B. Daly Editors Breast Cancer Risk Reduction and Early Detection 123 Editors Edward R. Sauter University of North Dakota School of
More informationMusculoskeletal Health in Women
Musculoskeletal Health in Women Elinor Mody Elizabeth Matzkin Editors Musculoskeletal Health in Women Editors Elinor Mody, MD Department of Rheumatology Gretchen and Edward Fish Center for Women s Health
More informationSpringerBriefs in Cancer Research
SpringerBriefs in Cancer Research For further volumes: http://www.springer.com/series/10786 Natalia Aptsiauri Angel Miguel Garcia-Lora Teresa Cabrera MHC Class I Antigens In Malignant Cells Immune Escape
More informationIn Clinical Practice
In Clinical Practice Taking a practical approach to clinical medicine, this series of smaller reference books is designed for the trainee physician, primary care physician, nurse practitioner and other
More informationUltrasound Mammography
Ultrasound Mammography B.-J. Hacke16er V. Duda G. Lauth Ultrasound Mammography Methods, Results, Diagnostic Strategies With the Collaboration of Jack Jellins Foreword by Elizabeth Kelly-Fry With 186 Illustrations
More informationNeurobiological Bases of Abnormal Aggression and Violent Behaviour
Neurobiological Bases of Abnormal Aggression and Violent Behaviour . József Haller Neurobiological Bases of Abnormal Aggression and Violent Behaviour József Haller Department of Behavioral Neurobiology
More informationWedge Biopsy for Diffuse Lung Diseases
Chapter VI Wedge Biopsy for Diffuse Lung Diseases Wedge biopsy via thoracoscopic biopsy or open lung biopsy is occasionally performed to obtain tissue for the diagnosis of a diffuse lung disease. A wedge
More informationThe Cleveland Clinic Manual of Dynamic Endocrine Testing
The Manual of Dynamic Endocrine Testing Ahmet Bahadir Ergin A. Laurence Kennedy Manjula K. Gupta Amir H. Hamrahian The Manual of Dynamic Endocrine Testing Ahmet Bahadir Ergin Department of Endocrinology,
More informationColor Atlas of High Resolution Manometry
Color Atlas of High Resolution Manometry Color Atlas of High Resolution Manometry Edited by Jeffrey Conklin, MD GI Motility Program Mark Pimentel, MD, FRCP(C) Cedars-Sinai Medical Center Edy Soffer, MD
More informationProgress in Social Psychiatry in Japan
Progress in Social Psychiatry in Japan Yoshibumi Nakane Progress in Social Psychiatry in Japan An Approach to Psychiatric Epidemiology Yoshibumi Nakane Department of Neuropsychiatry Nagasaki University
More informationEvidence-Based Forensic Dentistry
Evidence-Based Forensic Dentistry Balwant Rai Jasdeep Kaur Evidence-Based Forensic Dentistry Authors Balwant Rai Earth and Life Sciences Vrije Universiteit Amsterdam and ILEWG Amsterdam The Netherlands
More informationCross-Sectional Anatomy for Computed Tomography
Cross-Sectional Anatomy for Computed Tomography Michael L. Farkas Cross-Sectional Anatomy for Computed Tomography A Self-Study Guide with Selected Sections from Head, Neck, Thorax, Abdomen, and Pelvis
More informationWell-differentiated Papillary Mesothelioma of the Pleura Diagnosed by Video-Assisted Thoracic Surgical Pleural Biopsy : A Case Report
Showa Univ J Med Sci 25 1, 67 72, March 2013 Case Report Well-differentiated Papillary Mesothelioma of the Pleura Diagnosed by Video-Assisted Thoracic Surgical Pleural Biopsy : A Case Report Yuri TOMITA
More informationDyspepsia in Clinical Practice
Dyspepsia in Clinical Practice wwwwwwwwwwwwwwwww Dyspepsia in Clinical Practice Marko Duvnjak Editor Marko Duvnjak Department of Gastroenterology and Hepatology University Hospital Sestre milosrdnice Medical
More informationSami Shousha Editor. Breast Pathology. Problematic Issues
Breast Pathology Editor Breast Pathology Problematic Issues Editor Charing Cross Hospital Imperial College Healthcare NHS Trust & Imperial College London United Kingdom ISBN 978-3-319-28653-2 ISBN 978-3-319-28655-6
More informationUltrasonography of Muscles and Tendons
Ultrasonography of Muscles and Tendons Bruno D. Fomage Ultrasonography of Muscles and Tendons Examination Technique and Atlas of Normal Anatomy of the Extremities With 612 Illustrations Springer-Verlag
More informationCLINICAL GASTROENTEROLOGY
CLINICAL GASTROENTEROLOGY Series Editor George Y. Wu University of Connecticut Health Center, Farmington, CT, USA For further volumes: http://www.springer.com/series/7672 Elizabeth J. Carey Keith D. Lindor
More informationRadiation Therapy for Skin Cancer
Radiation Therapy for Skin Cancer Armand B. Cognetta Jr. William M. Mendenhall Editors Radiation Therapy for Skin Cancer Editors Armand B. Cognetta Jr. Dermatology Associates of Tallahassee Chief, Division
More informationJohn Papadopoulos David R. Schwartz Consulting Editor. Pocket Guide to Critical Care Pharmacotherapy Second Edition
John Papadopoulos David R. Schwartz Consulting Editor Pocket Guide to Critical Care Pharmacotherapy Second Edition 123 Pocket Guide to Critical Care Pharmacotherapy John Papadopoulos Author David R. Schwartz
More informationManagement of Headache and Headache Medications
Management of Headache and Headache Medications Lawrence D. Robbins, M.D. Management of Headache and Headache Medications Foreword by Jerome Goldstein, M.D. Springer-Verlag New York Berlin Heidelberg London
More informationPATHOLOGY OF MALIGNANT MELANOMA
PATHOLOGY OF MALIGNANT MELANOMA Springer Science+Business Media, LLC PATHOLOGY of MALIGNANT MELANOMA Raymond L. Barnhill, MD Professor of Dermatology and Pathology, Departments of Dermatology and Pathology,
More informationGynecologic Oncology
Gynecologic Oncology Ramez N. Eskander Robert E. Bristow Editors Gynecologic Oncology A Pocketbook Editors Ramez N. Eskander, M.D. Assistant Professor Division of Gynecologic Oncology Department of Obstetrics
More informationLocal Flaps in Facial Reconstruction
Local Flaps in Facial Reconstruction Velupillai Ilankovan Madan Ethunandan Tian Ee Seah Local Flaps in Facial Reconstruction A Defect Based Approach Velupillai Ilankovan Poole Hospital NHS Foundation
More informationEpidemiology, Pathogenesis, and Prevention of Head and Neck Cancer
Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer Andrew F. Olshan Editor Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer Editor Andrew F. Olshan, Ph.D. Professor and
More informationSurgical Techniques for Kidney Cancer
Surgical Techniques for Kidney Cancer Rakesh V. Khanna Gennady Bratslavsky Robert J. Stein Editors Surgical Techniques for Kidney Cancer 123 Editors Rakesh V. Khanna Department of Urology SUNY Upstate
More informationMark W.J. Strachan Brian M. Frier. Insulin Therapy. A Pocket Guide
Insulin Therapy Mark W.J. Strachan Brian M. Frier Insulin Therapy A Pocket Guide Mark W.J. Strachan, MD, FRCP (Ed) Metabolic Unit Western General Hospital Edinburgh United Kingdom Brian M. Frier, MD,
More informationMedical and Surgical Complications of Sickle Cell Anemia
Medical and Surgical Complications of Sickle Cell Anemia Ahmed Al-Salem Medical and Surgical Complications of Sickle Cell Anemia Ahmed Al-Salem Department of Surgery Dar A lalafia Medical Company Qatif
More informationApplications. in Oncology
Kewal K. Jain Applications of Biotechnology in Oncology Applications of Biotechnology in Oncology Applications of Biotechnology in Oncology Kewal K. Jain, MD, FRACS, FFPM Jain PharmaBiotech, Basel, Switzerland
More informationInflammation and Lung Cancer
Inflammation and Lung Cancer Steven M. Dubinett Editor Inflammation and Lung Cancer 1 3 Editor Steven M. Dubinett David Geffen School of Medicine at UCLA Los Angeles California USA ISBN 978-1-4939-2723-4
More informationThe Polyol Paradigm and Complications of Diabetes
The Polyol Paradigm and Complications of Diabetes Margo Panush Cohen The Polyol Paradigm and Complications of Diabetes With a Foreword by Harold Rifkin With 25 Figures Springer-Verlag New York Berlin Heidelberg
More informationCerebral Blood Flow, Metabolism, and Head Trauma
Cerebral Blood Flow, Metabolism, and Head Trauma Christian W. Kreipke Editors Jose A. Rafols Cerebral Blood Flow, Metabolism, and Head Trauma The Pathotrajectory of Traumatic Brain Injury Editors Christian
More informationRecurrent Erosion Syndrome and Epithelial Edema
Recurrent Erosion Syndrome and Epithelial Edema Helena M. Tabery Recurrent Erosion Syndrome and Epithelial Edema In Vivo Morphology in the Human Cornea Helena M. Tabery, MD Malmö Sweden helena.tabery@telia.com
More informationAtlas of Dermatology in Internal Medicine
Atlas of Dermatology in Internal Medicine wwwwwwwwwww Néstor P. Sánchez Editor Atlas of Dermatology in Internal Medicine Editor Néstor P. Sánchez Professor of Dermatology and Dermatopathology and Chairman
More informationAIDS Testing Methodology and Management Issues
AIDS Testing Gerald Schochetman J. Richard George Editors AIDS Testing Methodology and Management Issues Foreword by Walter R. Dowdle With 38 Illustrations Springer-Verlag New York Berlin Heidelberg London
More informationImaging of Urinary Tract Diverticula
Imaging of Urinary Tract Diverticula Vladimir M. Builov Imaging of Urinary Tract Diverticula Vladimir M. Builov Department of X-Ray and MRI RailWay Clinical Hospital Yaroslavl Russia ISBN 978-3-319-05382-0
More informationDeveloping and Evaluating Educational Programs for Students with Autism
Developing and Evaluating Educational Programs for Students with Autism Caroline I. Magyar Developing and Evaluating Educational Programs for Students with Autism Caroline I. Magyar Department of Pediatrics
More informationAbnormal Female Puberty
Abnormal Female Puberty Heather L. Appelbaum Editor Abnormal Female Puberty A Clinical Casebook Editor Heather L. Appelbaum, MD Department of Obstetrics and Gynecology Hofstra Northwell School of Medicine
More informationTadaaki Kirita Ken Omura Editors. Oral Cancer. Diagnosis and Therapy
Oral Cancer Tadaaki Kirita Ken Omura Editors Oral Cancer Diagnosis and Therapy Editors Tadaaki Kirita Department of Oral and Maxillofacial Surgery Nara Medical University Nara, Japan Ken Omura Oral Cancer
More informationVasilis Vasiliou. Q. Max Guo. Alcohol and Cancer
Alcohol and Cancer Samir Zakhari Editors Vasilis Vasiliou Q. Max Guo Alcohol and Cancer Editors Samir Zakhari, Ph.D. Director Division of Metabolism and Health Effects National Institute on Alcohol Abuse
More informationWhite Coat Hypertension
White Coat Hypertension Giuseppe Mancia Guido Grassi Gianfranco Parati Alberto Zanchetti White Coat Hypertension An Unresolved Diagnostic and Therapeutic Problem Giuseppe Mancia Emeritus Professor University
More informationProgressive Multiple Sclerosis
Progressive Multiple Sclerosis Alastair Wilkins Editor Progressive Multiple Sclerosis Editor Alastair Wilkins, M.A., M.B., B.Chir, Ph.D., FRCP Department of Neurology Frenchay Hospital Bristol UK ISBN
More informationEsthetic and Functional Management of Diastema
Esthetic and Functional Management of Diastema Ugur Erdemir Esra Yildiz Editors Esthetic and Functional Management of Diastema A Multidisciplinary Approach Editors Ugur Erdemir Faculty of Dentistry University
More informationSUPPORTIVE CARE IN CANCER THERAPY
SUPPORTIVE CARE IN CANCER THERAPY For other titles published in this series, go to www.springer.com/series/7625 SUPPORTIVE CARE IN CANCER THERAPY Edited by DAVID S. ETTINGER, MD The Sidney Kimmel Comprehensive
More informationWound Management in Urgent Care
Wound Management in Urgent Care Brittany Busse Wound Management in Urgent Care Brittany Busse, MD Med 7 Urgent Care Folsom, CA, USA ISBN 978-3-319-27426-3 DOI 10.1007/978-3-319-27428-7 ISBN 978-3-319-27428-7
More informationErin Lawson Mark S. Wallace Editors. Fibromyalgia. Clinical Guidelines and Treatments
Fibromyalgia Erin Lawson Mark S. Wallace Editors Fibromyalgia Clinical Guidelines and Treatments Editors Erin Lawson, MD Voluntary Faculty Department of Anesthesiology Center for Pain Medicine University
More informationIatrogenic Effects of Orthodontic Treatment
Iatrogenic Effects of Orthodontic Treatment Roberto Justus Iatrogenic Effects of Orthodontic Treatment Decision-Making in Prevention, Diagnosis, and Treatment Roberto Justus Department of Orthodontics
More informationMorbid Obesity in Adolescents
Morbid Obesity in Adolescents ThiS is a FM Blank Page Kurt Widhalm Gerhard Prager Editors Morbid Obesity in Adolescents Conservative Treatment and Surgical Approaches Editors Kurt Widhalm Department of
More informationHandbook for Venous Thromboembolism
Handbook for Venous Thromboembolism Gregory Piazza Benjamin Hohlfelder Samuel Z. Goldhaber Handbook for Venous Thromboembolism Gregory Piazza Cardiovascular Division Harvard Medical School Brigham and
More informationRadiation Therapy for Head and Neck Cancers
Radiation Therapy for Head and Neck Cancers Murat Beyzadeoglu Gokhan Ozyigit Ugur Selek Editors Radiation Therapy for Head and Neck Cancers A Case-Based Review Editors Murat Beyzadeoglu, MD Professor
More informationBenign Breast Diseases
Catherine N. Chinyama Benign Breast Diseases Radiology Pathology Risk Assessment Second Edition 123 Benign Breast Diseases Catherine N. Chinyama Benign Breast Diseases Radiology - Pathology - Risk Assessment
More informationRecent Research in Psychology
Recent Research in Psychology 1.0. Fisher R.C. Silver 1.M. Chinsky B. Goff Y. Klar Evaluating a Large Group Awareness Training A Longitudinal Study of Psychosocial Effects Springer-Verlag New York Berlin
More informationPediatric Endodontics
Pediatric Endodontics Anna B. Fuks Benjamin Peretz Editors Pediatric Endodontics Current Concepts in Pulp Therapy for Primary and Young Permanent Teeth Editors Anna B. Fuks Department of Pediatric Dentistry
More informationEmerging Concepts of Tumor Exosome Mediated Cell Cell Communication
Emerging Concepts of Tumor Exosome Mediated Cell Cell Communication Huang-Ge Zhang Editor Emerging Concepts of Tumor Exosome Mediated Cell Cell Communication 2123 Editor Huang-Ge Zhang University of Louisville
More informationIdentifying, Assessing, and Treating Conduct Disorder at School
Identifying, Assessing, and Treating Conduct Disorder at School Developmental Psychopathology at School Series Editors: Shane R. Jimerson, University of California, Santa Barbara, CA, USA Stephen E. Brock,
More informationSeries in Psychopathology. Series Editor Lauren B. Alloy
Series in Psychopathology Series Editor Lauren B. Alloy Michael W. O'Hara Postpartum Depression Causes and Consequences With a Foreword by Lee S. Cohen, M.D. With 22 Illustrations Springer-Verlag New York
More informationIntraductal Papillary Mucinous Neoplasm of the Pancreas. Masao Tanaka Editor
Intraductal Papillary Mucinous Neoplasm of the Pancreas Masao Tanaka Editor Intraductal Papillary Mucinous Neoplasm of the Pancreas Masao Tanaka Editor Intraductal Papillary Mucinous Neoplasm of the Pancreas
More informationBeating Drug Tests and Defending Positive Results
Beating Drug Tests and Defending Positive Results Amitava Dasgupta Beating Drug Tests and Defending Positive Results A Toxicologist s Perspective Amitava Dasgupta Department of Pathology and Laboratory
More informationPlanning and Care for Children and Adolescents with Dental Enamel Defects
Planning and Care for Children and Adolescents with Dental Enamel Defects Etiology, Research and Contemporary Management Bernadette K. Drummond Nicola Kilpatrick Editors 123 Planning and Care for Children
More informationMorphological Aspects of Inner Ear Disease
Morphological Aspects of Inner Ear Disease Yasuya Nomura Morphological Aspects of Inner Ear Disease Yasuya Nomura President The Society for Promotion of International Oto-Rhino-Laryngology Tokyo, Japan
More informationMinimally Invasive Gynecological Surgery
Minimally Invasive Gynecological Surgery O l av Is t re Editor Minimally Invasive Gynecological Surgery Editor Olav Istre, MD, PhD Fredriksberg Denmark ISBN 978-3-662-44058-2 ISBN 978-3-662-44059-9 (ebook)
More informationDonald E. Wesson. Editor. Metabolic Acidosis. A Guide to Clinical Assessment and Management
Metabolic Acidosis Donald E. Wesson Editor Metabolic Acidosis A Guide to Clinical Assessment and Management Editor Donald E. Wesson, MD, MBA Baylor Scott and White Health Department of Internal Medicine
More informationThomas Reinhard Frank Larkin Editors. Corneal Disease. Recent Developments in Diagnosis and Therapy
Corneal Disease Thomas Reinhard Frank Larkin Editors Corneal Disease Recent Developments in Diagnosis and Therapy Editors Prof. Dr. med. Thomas Reinhard University Eye Hospital Freiburg Germany Dr. Frank
More informationCentral Nervous System Diseases and Inflammation
Central Nervous System Diseases and Inflammation Thomas E. Lane Monica Carson Conni Bergmann Tony Wyss-Coray Editors Central Nervous System Diseases and Inflammation Thomas E. Lane Center for Immunology
More informationBleeding During Pregnancy
Bleeding During Pregnancy Eyal Sheiner Editor Bleeding During Pregnancy A Comprehensive Guide Editor Eyal Sheiner, MD, PhD Department of Obstetrics and Gynecology Faculty of Health Sciences Soroka University
More informationMitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy
Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy Dhyan Chandra Editor Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy 1 3 Editor Dhyan Chandra, Associate
More informationDeep Brain Stimulation for Neurological Disorders
Deep Brain Stimulation for Neurological Disorders Toru I t a k u ra Editor Deep Brain Stimulation for Neurological Disorders Theoretical Background and Clinical Application Editor Toru Itakura, MD, PhD
More informationReconstructive Oral and Maxillofacial Surgery
Reconstructive Oral and Maxillofacial Surgery Carlos Navarro Vila Editor Reconstructive Oral and Maxillofacial Surgery Editor Carlos Navarro Vila Hospital General Universitario Gregorio Marañón Madrid
More informationClinical PET and PET/CT
Clinical PET and PET/CT E. Edmund Kim Myung-Chul Lee Tomio Inoue Wai-Hoi Wong Editors Clinical PET and PET/CT Principles and Applications Second Edition Editors E. Edmund Kim Departments of Nuclear Medicine
More informationPractical Case Studies in Hypertension Management. Series editor: Giuliano Tocci Rome Italy
Practical Case Studies in Hypertension Management Series editor: Giuliano Tocci Rome Italy The aim of the book series Practical Case Studies in Hypertension Management is to provide physicians who treat
More informationSpringer Handbook of Auditory Research
Springer Handbook of Auditory Research Series Editors: Richard R. Fay and Arthur N. Popper For other titles published in this series, go to www.springer.com/series/2506 Ray Meddis Enrique A. Lopez-Poveda
More informationIndirect Questioning in Sample Surveys
Indirect Questioning in Sample Surveys Arijit Chaudhuri Tasos C. Christofides Indirect Questioning in Sample Surveys 123 Arijit Chaudhuri Applied Statistics Unit Indian Statistical Institute Kolkata,
More informationSpringerBriefs in Applied Sciences and Technology
SpringerBriefs in Applied Sciences and Technology Computational Intelligence Series Editor Janusz Kacprzyk, Systems Research Institute, Polish Academy of Sciences, Warsaw, Poland SpringerBriefs in Computational
More information