Immunotherapies for aplastic anemia
|
|
- Jewel Hawkins
- 5 years ago
- Views:
Transcription
1 Workshop on Hematology and Bone Marrow Transplant May 11 12, 2018, São Paulo Immunotherapies for aplastic anemia Diego Villa Clé, MD, PhD Attending Physician Hospital das Clínicas Faculdade de Medicina de Ribeirão Preto - USP
2 % Tcell suppression AA an autoimmune disease Autologous recovery after allo HSCT in AA Immunosuppression needed in syngeneic HSCT IFN levels Treg Controls AA Controls AA 1- Thomas et al. Exp Hematol 1976; 2- Champlim et al. Br J Haematol Zoumbos et al. PNAS 1985; 4- Solomou et al. Blood Shi et al. Blood 2012
3 Young, Calado & Scheinberg, Blood 2006
4 Immunosuppressive therapy Corticosteroids ~10% response hatg 40 50% response hatg + CSA 60 70% response Di Bona E et al. Br J Haematol 1999;107: Di Bona E et al. Br J Haematol 1999;107:
5 Absolute lymphocyte count cells/µl Rabbit ATG: profound lymphodepleting 2500 hatg ratg Time (days) Scheinberg P et al. Blood 2007;109: Scheinberg P et al. Blood 2012;119:
6 Sobrevida (%) Horse x rabbit ATG in SAA Hematologic response ATG horse ATG rabbit P- value months (62%) (33%) months (68%) (37%) < ATG horse ATG rabbit Anos horse ATG: higher response and OS gold-standard IST: hatg + Cyclosporine Scheinberg P et al. N Engl J Med 2011
7 Horse x rabbit ATG in SAA Study (year) hatg (N) ratg (N) hatg response (%) ratg response (%) Zheng (2006) 47 (Lympho) 32 (Fr) Atta (2010) 42 (Lympho) Design Prospective, randomized 29 (Thymo) Retrospective Afable (2011) 67 (ATGAM) 20 (Thymo) Retrospective Scheinberg (2011) 60 (ATGAM) 60 (Thymo) Prospective, randomized Marsh (2012) 105 (Lympho) 35 (Thymo) Prospective Shin (2013) 46 (Lympho) 53 (Thymo) Retrospective Yoshimi (2013) 96 (Lympho) 32 (Thymo) Retrospective Vallejo (2015) 62 (Lympho) 162 (Thymo) Retrospective Clé (2018) 85 (Lympho) 170 (Thymo) Retrospective
8 Rabbit ATG: useful in SAA? CSA monotherapy in AA ratg dose LogRank test = mg/kg/d 3.0 mg/kg/d 3.5 mg/kg/d 5.0 mg/kg/d time(days) Number at risk 2.5 mg/kg/d mg/kg/d mg/kg/d Shetty M. et al. J Clin Diag Res 2016 Clé DV. Manuscript in publication
9 Increase immunosuppression intensity? Corticosteroids ~10% response hatg 40 50% response hatg + CSA 60 70% response Adding a third drug
10 Improve immunosuppression? Alemtuzumab: 19% overall response. Early discontinued (toxicity) 3 Cyclophosphamide:. 71% overall response. Fungal infections(21-39%) 4 1- Scheinberg P. et al. Br J Haematol 2006;133(6):606-11; 2-Scheinberg P. et al. Haematologica 2009;94(3):348-54; 3-Scheinberg P. et al. Blood 2012;119(2): ; 4-Brodsky RA. et al. Blood 2010;115(11):
11 Refractoriness 1/3 of patients (2/3 in Brazil) Insufficient Immunosuppression? HSC and progenitor cells exhaustion?
12 Thrombopoietin and hematopoiesis Selfrenewal HSC Multipotent stem cell Primitive progenitor cells CMP SCF TPO IL-7 CLP TPO-R ELTROMBOPAG Committed precursor cells IL-3 SCF TPO GM-CSF MEP GM TNK BCP IL-7 IL-7 Eltrombopag & Transmembrane domain Lineage committed cells MkP TPO TPO EPO EP EPO MP GP TCP NKP M-CSF G-CSF IL-5 SCF IL-7 IL-2 IL-7 IL-2 IL-7 IL-15 IL-15 IL-4 JAK2 kinase Stat RAS/R AF MEK MAPK /ERK Platelets Erythrocytes Monocytes Neutrophils, Eosinophils T cells NK cells B cells De Laval B et al. Cell Stem Cell 2013;12:37 48
13 Eltrombopag + IST: 1 st line hatg Day 1-4 Hematologic response CSA 6 months 3 months 6 months Cohort 1 Cohort 2 Eltrombopag 150 mg Day 14 to 3 months Eltrombopag 150 mg Day 14 to 6 months 5 years follow-up Cohort 3 Eltrombopag 150 mg Day 1 to 6 months Townsley DM et al. N Engl J Med 2017;376:
14 Eltrombopag + IST: 1 st line 3 months Cohort 1 N=30 Cohort 2 N=31 Cohort 3 N=31 OR 23 (77%) 24 (77%) 27 (87%) RC 5 (17%) 8 (26%) 15 (48%) 6 months OR 24 (80%) 27 (87%) 29 (94%) RC 10 (33%) 8 (26%) 18 (58%) 2 years OS: 97% Townsley DM et al. N Engl J Med 2017;376:
15 Eltrombopag + IST: 1 st line 3 months Cohort 1 N=30 Cohort 2 N=31 Cohort 3+ext N=88 OR 23 (77%) 24 (77%) 66 (75%) RC 5 (17%) 8 (26%) 25 (28%) 6 months OR 24 (80%) 27 (87%) 69 (79%) RC 10 (33%) 8 (26%) 38 (44%)
16 RACE study: TPO-R agonists added to standard IST for firstline treatment of patients with SAA Hematologic response at 3 and 6 months hatg 4 days Arm 1 (n=100) Arm 2 (n=100) CSA 12 months Standard IST Standard IST plus eltrombopag 150 mg Day 14 to 3 months 5-year follow-up Primary endpoints: CR rate at 6 months, toxicity (ANC 1 x10 9 /L, hemoglobin 10 g/dl, and platelets 100 x10 9 /L) EudraCT Number: For presentation in response to an unsolicited request for medical information subject to local NP4 approval. Not for distribution
17 SOAR trial: Eltrombopag + CSA in 1 st line FPFV 09/2016 Hematologic response 3 months 6 months 12 months CSA 24 months Eltrombopag 150 mg Day 0 to 6 months 5 years follow-up Primary Endpoints: OR to 6 months Secondary Endpoints: 3 and 12 months OR, survival and safety For presentation in response to an unsolicited request for medical information subject to local NP4 approval. Not CETB115 for 2403 distribution
18 Conclusions Although improvements have been made in IST, approximately one-third of patients (2/3 in Brazil) remains refractory. hatg is superior to ratg in first-line treatment of SAA and must be the gold standard IST. Increased intensity of immunosuppressive therapy has not improved outcomes We probably reached the limit for IST. Eltrombopag has been improving IST outcomes. However, results of ongoing randomized trials comparing IST with and without eltrombopag are pending.
19 For presentation in response to an unsolicited request for medical information subject to local NP4 approval. Not for distribution Rodrigo Calado Guilherme Darrigo Roberto Falcão Belinda Simões Eduardo Rego Fabíola Traina André Pinto Barbara Santana Fernanda Rodriguez Flavia Donaires Florencia Tellechea João Paulo Silva Lilian Figueiredo Phillip Scheinberg Carmem Bonfim Larissa Medeiros Michel Oliveira Ricardo Pasquini Marco Salvino Sara Saad Elvira Velloso Marlene Garanito Elias Atta Carlos Bernardo Lima Patricia Blum Fonseca Thank you
Pacientes jovens sem doador com anemia aplástica grave devem receber TMO de fonte alternativa de CTH NO!
Pacientes jovens sem doador com anemia aplástica grave devem receber TMO de fonte alternativa de CTH NO! Phillip Scheinberg, MD Head, Clinical Hematology Hospital A Beneficência Portuguesa de Sao Paulo
More informationImmunosuppressive treatment in acquired aplastic anemia. André Tichelli Hematology, University Hospital Basel
Immunosuppressive treatment in acquired aplastic anemia André Tichelli Hematology, University Hospital Basel Why is immunosuppressive treatment a choice for acquired aplastic anemia? Hematopoietic stem
More informationShall young patients with severe aplastic anemia without donors receive BMT from alternative source of HCT? Elias Hallack Atta, MD, PhD
Shall young patients with severe aplastic anemia without donors receive BMT from alternative source of HCT? Elias Hallack Atta, MD, PhD Declaração de Conflito de Interesse Declaro que possuo conflito de
More informationThe function of the bone marrow. Living with Aplastic Anemia. A Case Study - I. Hypocellular bone marrow failure 5/14/2018
The function of the bone marrow Larry D. Cripe, MD Indiana University Simon Cancer Center Bone Marrow Stem Cells Mature into Blood Cells Mature Blood Cells and Health Type Function Term Red Cells Carry
More informationAplastic Anemia: Understanding your Disease and Treatment Options
Aplastic Anemia: Understanding your Disease and Treatment Options No financial relationships or commercial interest related to the content of this presentation Josh Sasine, MD, PhD Hematopoietic Cell Transplant
More informationYes Antonio M. Risitano, M.D., Ph.D. Head of Bone Marrow Transplantation Unit Federico II University of Naples
4ème Journée Nationale Maladies Rares Immuno-Hématologiques Paris, June 7th 2018 Matched unrelated upfront transplantation in idiopathic aplastic anemia? Yes Antonio M. Risitano, M.D., Ph.D. Head of Bone
More informationAplastic Anemia: Current Thinking on Disease, Diagnosis and Non- Transplant Treatment
7/23/212 Aplastic Anemia: Current Thinking on Disease, Diagnosis and Non- Transplant Treatment Danielle Townsley, MD, MSc Hematology Branch National, Heart, Lung and Blood Institute National Institutes
More informationOverview of Aplastic Anemia. Overview of Aplastic Anemia. Epidemiology of aplastic anemia. Normal hematopoiesis 10/6/2017
Overview of Aplastic Anemia Overview of Aplastic Anemia Peter Westervelt, MD, PhD Professor of Medicine Chief, BMT/Leukemia Section Washington University School of Medicine Epidemiology Normal hematopoiesis
More informationOUTCOME AFTER IMMUNOSUPPRESSION
OUTCOME AFTER IMMUNOSUPPRESSION EBMT Aplastic Anemia Educational Meeting Budapest November 1 st 2012 Antonio M. Risitano, M.D., Ph.D. Head of Bone Marrow Transplant Unit Hematology, DBBM Federico II University
More informationAplastic Anemia: Current Thinking on Disease, Diagnosis and Non- Transplant Treatment
4/18/212 Aplastic Anemia: Current Thinking on Disease, Diagnosis and Non- Transplant Treatment Bogdan Dumitriu, MD Hematology Branch National, Heart, Lung and Blood Institute National Institutes of Health
More informationCynthia Fata, MD, MSPH 6/23/15
Cynthia Fata, MD, MSPH 6/23/15 Clinical case presentation Introduction to thrombopoietin Development of thrombopoietic agents Clinical Indications Eltrombopag use in aplastic anemia Future uses 33 yo F
More information3/31/2014. New Directions in Aplastic Anemia Treatment: What s on the Horizon? Objectives
New Directions in Aplastic Anemia Treatment: What s on the Horizon? AA & MDS International Foundation Living with, MDS, or PNH Patient and Family Conferences in 2014 April 5, 2014 Objectives To provide
More informationMUD HSCT as first line Treatment in Idiopathic SAA. Dr Sujith Samarasinghe Great Ormond Street Hospital for Children, London, UK
MUD HSCT as first line Treatment in Idiopathic SAA Dr Sujith Samarasinghe Great Ormond Street Hospital for Children, London, UK No Financial Disclosures Guidelines for management of aplastic anaemia British
More informationAplastic Anemia. is a bone marrow failure disease 9/19/2017. What you need to know about. The 4 major components of blood
What you need to know about Aplastic Anemia Stuart Goldberg MD Aplastic Anemia is a bone marrow failure disease The bone marrow is the factory that makes blood The 4 major components of blood Red Blood
More informationSevere Aplastic Anemia in Children and Adolescents. Brigitte Strahm 21. April 2018
Severe Aplastic Anemia in Children and Adolescents Brigitte Strahm 21. April 2018 Acquired Aplastic Anemia in children What is aquired aplastic anemia? Camitta, Blood 1976 How A.L.G. acts is unknown, but
More informationOutline. What is aplastic anemia? 9/19/2012. Aplastic Anemia Current Thinking on the Disease, Diagnosis, and Non-Transplant Treatment Options
Aplastic Anemia Current Thinking on the Disease, Diagnosis, and Non-Transplant Treatment Options Carlos M. de Castro, MD Duke University Medical Center Outline What is Aplastic Anemia? What other diseases
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the author to give readers additional information about his work. Supplement to: Olnes MJ, Scheinberg P, Calvo KR, et al. Eltrombopag and improved
More informationPromacta (eltrombopag)
Promacta (eltrombopag) Policy Number: 5.01.542 Last Review: 5/2018 Origination: 6/2013 Next Review: 5/2019 Policy Blue Cross and Blue Shield of Kansas City (Blue KC) will provide coverage for Promacta
More information3/31/2014. Aplastic Anemia: Current Thinking on the Disease, Diagnosis, and Non-Transplant Treatment. Objectives
Aplastic Anemia: Current Thinking on the Disease, Diagnosis, and Non-Transplant AA & MDS International Foundation 2014 Living with Aplastic Anemia, MDS, or PNH Patient and Family Conferences (Los Angeles
More informationHow I treat acquired aplastic anemia
How I treat acquired aplastic anemia Phillip Scheinberg and Neal S. Young Blood Volume 120(6):1185-1196 August 9, 2012 2012 by American Society of Hematology Symptoms, Signs, and Lab Findings Bruising,
More informationDisclosers Updates: Management of Aplastic Anemia and Congenital Marrow Failure 5/9/2017
2017 Updates: Management of Aplastic Anemia and Congenital Marrow Failure Sachit Patel, MD Department of Pediatrics Division of Hematology-Oncology Blood and Marrow Transplantation Disclosers None 1 Objectives:
More informationIdelalisib treatment is associated with improved cytopenias in patients with relapsed/refractory inhl and CLL
Idelalisib treatment is associated with improved cytopenias in patients with relapsed/refractory inhl and CLL Susan M O Brien, Andrew J Davies, Ian W Flinn, Ajay K Gopal, Thomas J Kipps, Gilles A Salles,
More information9/9/2015 HISTORY & EPIDEMIOLOGY. Objectives. Textbook Definition of Aplastic anemia (AA) Epidemiology. History
Objectives Aplastic Anemia: Current Thinking on the Disease, Diagnosis, and Non-Transplant Treatment Amy E. DeZern, MD, MHS Assistant Professor of Oncology and Medicine The Johns Hopkins University School
More informationLatest results of sibling HSCT in acquired AA. Jakob R Passweg
Latest results of sibling HSCT in acquired AA Jakob R Passweg Impact on Outcome: Patient Age, Disease Severity Title: Optimization of Therapy for Severe Aplastic Anemia Based on Clinical, Biological and
More informationHematopoietic Stem Cell Transplantation for Systemic Sclerosis. Maria Carolina de Oliveira Ribeirão Preto Medical School University of São Paulo 2018
Hematopoietic Stem Cell Transplantation for Systemic Sclerosis Maria Carolina de Oliveira Ribeirão Preto Medical School University of São Paulo 2018 LOCALIZED SCLERODERMA Restricted to the skin Benign
More informationThe Immune System. A macrophage. ! Functions of the Immune System. ! Types of Immune Responses. ! Organization of the Immune System
The Immune System! Functions of the Immune System! Types of Immune Responses! Organization of the Immune System! Innate Defense Mechanisms! Acquired Defense Mechanisms! Applied Immunology A macrophage
More informationeltrombopag (Promacta )
Applies to all products administered or underwritten by Blue Cross and Blue Shield of Louisiana and its subsidiary, HMO Louisiana, Inc.(collectively referred to as the Company ), unless otherwise provided
More informationBor-Sheng Ko. Hematology Division, Department of Internal Medicine, National Taiwan University Hospital
Bor-Sheng Ko Hematology Division, Department of Internal Medicine, National Taiwan University Hospital On behalf of Members of Aplastic Anemia Consensus Meeting Diagnosis and classification: Treatment
More informationHaploidentical Stem Cell Transplantation with post transplantation Cyclophosphamide for the treatment of Fanconi Anemia
Haploidentical Stem Cell Transplantation with post transplantation Cyclophosphamide for the treatment of Fanconi Anemia Carmem Bonfim Director Pediatric Blood and Marrow Transplantation Program HC Federal
More informationAplastic Anemia: Understanding Your Disease and Treatment Options
APPROXIMATE BLOOD CELL REQUIREMENTS Aplastic Anemia: Understanding Your Disease and Treatment Options Danielle Townsley, MD, MSc Associate Director, Oncology AztraZeneca Medimmune cell type total number
More informationThrombopoietin Receptor Agonists Prior Authorization with Quantity Limit Program Summary
Thrombopoietin Receptor Agonists Prior Authorization with Quantity Limit Program Summary Thrombopoietin Receptor Agonists Prior Authorization with Quantity Limit OBJECTIVE The intent of the prior authorization
More informationFirst line treatment of aplastic anemia with thymoglobuline in Europe and Asia: Outcome of 955 patients treated
Received: 30 January 2018 Revised: 24 February 2018 Accepted: 26 February 2018 DOI: 10.1002/ajh.25081 RESEARCH ARTICLE First line treatment of aplastic anemia with thymoglobuline in Europe and Asia: Outcome
More informationPROMACTA (eltrombopag olamine) oral tablet and oral suspension
PROMACTA (eltrombopag olamine) oral tablet and oral suspension Coverage for services, procedures, medical devices and drugs are dependent upon benefit eligibility as outlined in the member's specific benefit
More informationPharmacy Prior Authorization
Pharmacy Prior Authorization AETA BETTER HEALTH PESLVAIA & AETA BETTER HEALTH KIDS Promacta (Medicaid) This fax machine is located in a secure location as required by HIPAA regulations. Complete/review
More informationShould we still use Camitta s criteria for severe aplastic anemia?
VOLUME 47 ㆍ NUMBER 2 ㆍ June 2012 THE KOREAN JOURNAL OF HEMATOLOGY ORIGINAL ARTICLE Should we still use Camitta s criteria for severe aplastic anemia? Hyun Hwa Yoon, Seok Jae Huh, Ji Hyun Lee, Suee Lee,
More informationAAMDSIF. Aplastic Anemia Research Summary from the DIAGNOSIS RTEL1 Mutations and Bone Marrow Failure
AAMDSIF Aplastic Anemia Research Summary from the 2016 AMERICAN SOCIETY OF HEMATOLOGY ANNUAL MEETING A Summary of Selected Scientific Abstracts for Patients with Aplastic Anemia and Their Caregivers DIAGNOSIS
More information2. Does the patient have a diagnosis of chronic idiopathic thrombocytopenic purpura (ITP)?
Pharmacy Prior Authorization MERC CARE (MEDICAID) Promacta (Medicaid) This fax machine is located in a secure location as required by HIPAA regulations. Complete/review information, sign and date. Fax
More informationa SAA-WP trial RACE study Sponsor Protocol Number: EudraCT TrialNumber: Coordinating Investigators:
A prospective Randomized multicenter study comparing horse Antithymocyte globuline (hatg) + Cyclosporine A (CsA) with or without Eltrombopag as front-line therapy for severe aplastic anemia patients. RACE
More informationService Line: Rapid Response Service Version: 1.0 Publication Date: July 09, 2018 Report Length: 7 Pages
CADTH RAPID RESPONSE REPORT: SUMMARY WITH CRITICAL APPRAISAL Eltrombopag for the treatment of Aplastic Anemia: A Review of Clinical and Cost-Effectiveness Service Line: Rapid Response Service Version:
More informationPharmacy Prior Authorization
Pharmacy Prior Authorization MERC CARE (MEDICAID) Promacta (Medicaid) This fax machine is located in a secure location as required by HIPAA regulations. Complete/review information, sign and date. Fax
More informationDiagnosis and Management of Immune Thrombocytopenias. Thomas L. Ortel, M.D., Ph.D. Duke University Medical Center 2 November 2016
Diagnosis and Management of Immune Thrombocytopenias Thomas L. Ortel, M.D., Ph.D. Duke University Medical Center 2 November 2016 Disclosures Research support: NIH, CDC, Eisai, Pfizer, Daiichi Sankyo, GlaxoSmithKline,
More informationNot So Benign Hematology Aplastic anemia, Paroxysmal Nocturnal Hemoglobinuria, atypical Hemolytic Uremic Syndrome, Thrombotic Thrombocytopenic Purpura
Not So Benign Hematology Aplastic anemia, Paroxysmal Nocturnal Hemoglobinuria, atypical Hemolytic Uremic Syndrome, Thrombotic Thrombocytopenic Purpura Robert A. Brodsky, MD Johns Hopkins Family Professor
More informationNot So Benign Hematology. Robert A. Brodsky, MD Johns Hopkins Family Professor of Medicine and Oncology Division Chief Hematology
Not So Benign Hematology Robert A. Brodsky, MD Johns Hopkins Family Professor of Medicine and Oncology Division Chief Hematology Disclosures Dr. Brodsky serves as a Scientific Advisory Board member to:
More informationHorse versus Rabbit Antithymocyte Globulin in Acquired Aplastic Anemia
The new england journal of medicine original article Horse versus Rabbit Antithymocyte Globulin in Acquired Aplastic Anemia Phillip Scheinberg, M.D., Olga Nunez, R.N., B.S.N., Barbara Weinstein, R.N.,
More informationOur place in the World
Our place in the World Sickle cell disease is a public health problem that is not going to end or decrease over the years In 2050 Brazil will have the same number of newborns as in 2010 In other regions
More informationParoxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine
Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine Phillip Scheinberg, Michael Marte, Olga Nunez, and Neal S. Young
More informationTherapeutic Advances in Treatment of Aplastic Anemia. Seiji Kojima MD. PhD.
Therapeutic Advances in Treatment of Aplastic Anemia Seiji Kojima MD. PhD. Department of Pediatrics Nagoya University Graduate School of Medicine Chairman of the Severe Aplastic Anemia Working Party Asia-Pacific
More informationStem Cell Transplantation for Severe Aplastic Anemia
Number of Transplants 10/24/2011 Stem Cell Transplantation for Severe Aplastic Anemia Claudio Anasetti, MD Professor of Oncology and Medicine Chair, Blood and Marrow Transplant Dpt Moffitt Cancer Center
More informationAplastic Anemia: Fill Er Up! But With What? Speaker s Disclosure Statement. Objectives. Aplastic Anemia: Fill Er Up? But With What?
Fill Er Up! But With What? Karyn Brundige, MSN, CPNP Dana-Farber/Boston Children s Cancer and Blood Disorders Center karyn.brundige@childrens.harvard.edu Speaker s Disclosure Statement I have no industry
More informationExpert Review: Updates in Immune Thrombocytopenia. Reference Slides
Expert Review: Updates in Immune Thrombocytopenia Reference Slides Immune Thrombocytopenia (ITP): Overview ITP causality 1,2 Suboptimal platelet production Dysregulated adaptive immune system Increased
More informationAplastic anemia: therapeutic updates in immunosuppression and transplantation
IMMUNE DYSREGULATION Aplastic anemia: therapeutic updates in immunosuppression and transplantation Phillip Scheinberg 1 1 Hematology Branch, National Heart, Lung and Blood Institute, National Institutes
More informationNontransplant therapy for bone marrow failure
Nontransplant therapy for bone marrow failure Danielle M. Townsley and Thomas Winkler BONE MARROW FAILURES Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD Nontransplant therapeutic
More informationClinical significance of acquired somatic mutations in aplastic anaemia
Int J Hematol (2016) 104:159 167 DOI 10.1007/s12185-016-1972-8 PROGRESS IN HEMATOLOGY Recent advance in the diagnosis and treatment of bone marrow failure syndromes Clinical significance of acquired somatic
More informationUse of TPO mimetics for Indications Other Than ITP
Use of TPO mimetics for Indications Other Than ITP Mazyar Shadman, MD, MPH Discussant: Siobán Keel, MD Hematology Fellows Conference June 28, 2013 Thrombopoietin (TPO) and other c mpl ligands TPO mimetics
More informationOne Day BMT Course by Thai Society of Hematology. Management of Graft Failure and Relapsed Diseases
One Day BMT Course by Thai Society of Hematology Management of Graft Failure and Relapsed Diseases Piya Rujkijyanont, MD Division of Hematology-Oncology Department of Pediatrics Phramongkutklao Hospital
More informationRiposta immune versus stato immune
Riposta immune versus stato immune Russell E. Lewis U.O. Malattie Infettive, Policlinico S. Orsola-Malpighi Dipartimento di Scienze Mediche e Chirurgiche Alma Mater Studiorum Università di Bologna Immunodeficiency
More informationObjectives. What is Aplastic Anemia. SAA 101: An Introductory Course to Severe Aplastic Anemia
SAA 101: An Introductory Course to Severe Aplastic Anemia David A. Margolis, MD Professor of Pediatrics/Medical College of Wisconsin Program Director/ Children s Hospital of Wisconsin BMT Program Objectives
More informationPNH PNH PNH 3/22/2016 PNH. Paroxysmal Nocturnal Hemoglobinuria (PNH): Current Thinking on the Disease PATHOGENESIS OF PNH
3//1 PATHGENESIS F PIG-A gene Bone Marrow Failure Disease Scientific Symposium Rockville, March 17-1, 1 1 71 9 3 Paroxysmal Nocturnal Hemoglobinuria (): Current Thinking on the Disease 119 5 15 PRTEIN
More informationDISCOVERING ATCC IMMUNOLOGICAL CELLS - MODEL SYSTEMS TO STUDY THE IMMUNE AND CARDIOVASCULAR SYSTEMS
DISCOVERING ATCC IMMUNOLOGICAL CELLS - MODEL SYSTEMS TO STUDY THE IMMUNE AND CARDIOVASCULAR SYSTEMS James Clinton, Ph.D. Scientist, ATCC February 19, 2015 About ATCC Founded in 1925, ATCC is a non-profit
More informationthrombopoietin receptor agonists and University of Washington January 13, 2012
Tickle me eltrombopag: thrombopoietin receptor agonists and the regulation of platelet production Manoj Menon University of Washington January 13, 2012 Outline Clinical case Pathophysiology of ITP Therapeutic
More informationThe evaluation of acquired aplastic anemia in children and unexpected frequency of varicella-zoster virus association: a single-center study
The Turkish Journal of Pediatrics 2008; 50: 342-348 Original The evaluation of acquired aplastic anemia in children and unexpected frequency of varicella-zoster virus association: a single-center study
More informationIn vivo effects of horse and rabbit antithymocyte globulin in patients with severe aplastic anemia
Washington University School of Medicine Digital Commons@Becker Open Access Publications 214 In vivo effects of horse and rabbit antithymocyte globulin in patients with severe aplastic anemia Xingmin Feng
More informationImmunosuppressive therapy for aplastic anemia: a single-center experience from western India
Annals of Hematology https://doi.org/10.1007/s00277-018-3487-2 ORIGINAL ARTICLE Immunosuppressive therapy for aplastic anemia: a single-center experience from western India Sandip Shah 1 Asha Anand 1 &
More informationEltrombopag Added to Standard Immunosuppression for Aplastic Anemia
The new england journal of medicine Original Article Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia Danielle M. Townsley, M.D., Phillip Scheinberg, M.D., Thomas Winkler, M.D., Ronan
More informationImmunogenetics in sickle cell disease. Karina Tozatto Maio 2018 USP-USPC Workshop on Hematology and Bone Marrow Transplant 11/05/2018
Immunogenetics in sickle cell disease Karina Tozatto Maio 2018 USP-USPC Workshop on Hematology and Bone Marrow Transplant 11/05/2018 Sickle cell disease Monogenic disorder Extremely variable phenotype
More informationTrends in Hematopoietic Cell Transplantation. AAMAC Patient Education Day Oct 2014
Trends in Hematopoietic Cell Transplantation AAMAC Patient Education Day Oct 2014 Objectives Review the principles behind allogeneic stem cell transplantation Outline the process of transplant, some of
More information5/9/2018. Bone marrow failure diseases (aplastic anemia) can be cured by providing a source of new marrow
5/9/2018 or Stem Cell Harvest Where we are now, and What s Coming AA MDS International Foundation Indianapolis IN Luke Akard MD May 19, 2018 Infusion Transplant Conditioning Treatment 2-7 days STEM CELL
More informationHematopoiesis. BHS Liège 27/1/2012. Dr Sonet Anne UCL Mont-Godinne
Hematopoiesis BHS Liège 27/1/2012 Dr Sonet Anne UCL Mont-Godinne Hematopoiesis: definition = all the phenomenons to produce blood cells Leukocytes = White Blood Cells Polynuclear = Granulocytes Platelet
More informationStem Cells And The Future of Regenerative Medicine. Dipnarine Maharaj, M. D., FACP
Stem Cells And The Future of Regenerative Medicine Dipnarine Maharaj, M. D., FACP The following potential conflict of interest relationships are germane to my presentation. Employment: South Florida Bone
More informationAndrew Schorr: Dr. Young, for patients receiving initial treatment could you discuss the findings comparing horse ATG and rabbit ATG?
What s New in Aplastic Anemia Treatment American Society of Hematology Meeting December 2011 Dr. Neal S. Young Please remember the opinions expressed on Patient Power are not necessarily the views of our
More informationImmune Reconstitution Following Hematopoietic Cell Transplant
Immune Reconstitution Following Hematopoietic Cell Transplant Patrick J. Kiel, PharmD, BCPS, BCOP Clinical Pharmacy Specialist Indiana University Simon Cancer Center Conflicts of Interest Speaker Bureau
More informationImmunosuppressive Therapy and Bone Marrow Transplantation for Aplastic Anaemia The CMC Experience
36 supplement to Journal of the association of physicians of india Published on 1st of every month 1st march, 2015 Immunosuppressive Therapy and Bone Marrow Transplantation for Aplastic Anaemia The CMC
More informationCase Report Response of Paroxysmal Nocturnal Hemoglobinuria Clone with Aplastic Anemia to Rituximab
Case Reports in Hematology Volume 212, Article ID 16182, 5 pages doi:1.1155/212/16182 Case Report Response of Paroxysmal Nocturnal Hemoglobinuria Clone with Aplastic Anemia to Rituximab Radha Raghupathy
More informationAllogeneic Hematopoietic Stem Cell Transplantation: State of the Art in 2018 RICHARD W. CHILDS M.D. BETHESDA MD
Allogeneic Hematopoietic Stem Cell Transplantation: State of the Art in 2018 RICHARD W. CHILDS M.D. BETHESDA MD Overview: Update on allogeneic transplantation for malignant and nonmalignant diseases: state
More informationCase. Case. Case. Case. Case 6/27/2017. Aplastic Anemia: Understanding Your Diagnosis and Treatment Options. AAMDS Foundation
Aplastic Anemia: Understanding Your Diagnosis and Treatment Options AAMDS Foundation Winfred Wang, MD St. Jude Children s Research Hospital June 24, 2017 15 year old previously healthy white adolescent
More informationAplastic Anemia and related bone marrow failures. Ryotaro Nakamura, MD Department of Hematology/HCT City of Hope National Medical Center Duarte, CA
Aplastic Anemia and related bone marrow failures Ryotaro Nakamura, MD Department of Hematology/HCT City of Hope National Medical Center Duarte, CA CONFLICTS OF INTEREST Advisory Board meetings: Merck,
More informationTreatment of Thrombocytopenia After Allogeneic Hematopoietic Stem Cell Transplantation with Eltrombopag
Treatment of Thrombocytopenia After Allogeneic Hematopoietic Stem Cell Transplantation with Eltrombopag Kırık Melya Pelin 1, Gündeş Ilknur 1, Sarıfakıoğulları Serpil 2, Haydaroğlu Handan 2, Pehlivan Mustafa
More informationT-CELL DEPLETION: ALEMTUZUMAB IN THE BAG
UCT T-CELL DEPLETION: ALEMTUZUMAB IN THE BAG Nicolas Novitzky PhD, FCP(SA) Engraftment variables in Allo SCT Host HLA identity Integrity of marrow stroma Disease type and status Previous chemotherapy Graft
More informationClinical Policy: Eltrombopag (Promacta) Reference Number: ERX.SPA.71 Effective Date:
Clinical Policy: (Promacta) Reference Number: ERX.SPA.71 Effective Date: 10.01.16 Last Review Date: 11.18 Revision Log See Important Reminder at the end of this policy for important regulatory and legal
More informationReduced-intensity Conditioning Transplantation
Reduced-intensity Conditioning Transplantation Current Role and Future Prospect He Huang M.D., Ph.D. Bone Marrow Transplantation Center The First Affiliated Hospital Zhejiang University School of Medicine,
More informationElias Hallack Atta, 1 Adriana Martins de Sousa, 1 Marcelo Ribeiro Schirmer, 1 Luis Fernando Bouzas, 1 Marcio Nucci, 2 Eliana Abdelhay 1
Different Outcomes between Cyclophosphamide Plus Horse or Rabbit Antithymocyte Globulin for HLA-Identical Sibling Bone Marrow Transplant in Severe Aplastic Anemia Elias Hallack Atta, 1 Adriana Martins
More informationMyelodysplastic syndromes: 2018 update on diagnosis, risk-stratification and management
Received: 2 October 2017 Accepted: 2 October 2017 DOI: 10.1002/ajh.24930 ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES Myelodysplastic syndromes: 2018 update on diagnosis, risk-stratification and
More informationHematopoietic Growth Factors Colony Stimulating Factors. Erythropoietin (Epoetin alfa). Granulocyte-macrophage colonystimulating factor (G-CSF).
Hematopoietic Growth Factors Colony Stimulating Factors. Erythropoietin (Epoetin alfa). Granulocyte colony-stimulating factor(g-csf). Granulocyte-macrophage colonystimulating factor (G-CSF). Interleukin-11
More informationHematopoietic Stem Cells, Stem Cell Processing, and Transplantation
Hematopoietic Stem Cells, Stem Cell Processing, and Joseph (Yossi) Schwartz, M irector, Hemotherapy and Stem Cell Processing Facility Bone Marrow Can Cure: Leukemia Lymphoma Multiple Myeloma Genetic iseases:
More informationBorder between aplastic anemia and myelodysplastic syndrome
Int J Hematol (2013) 97:558 563 DOI 10.1007/s12185-013-1324-x PROGRESS IN HEMATOLOGY Advances in the management of acquired aplastic anemia (AA) Border between aplastic anemia and myelodysplastic syndrome
More informationAtgam (lymphocyte immune globulin, anti-thymocyte globulin [equine])
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.20.01 Subject: Atgam Page: 1 of 5 Last Review Date: June 24, 2016 Atgam Description Atgam (lymphocyte
More informationBack to the Future: The Resurgence of Bone Marrow??
Back to the Future: The Resurgence of Bone Marrow?? Thomas Spitzer, MD Director. Bone Marrow Transplant Program Massachusetts General Hospital Professor of Medicine, Harvard Medical School Bone Marrow
More informationLong-term innate immune memory via effects on bone marrow progenitors
Long-term innate immune memory via effects on bone marrow progenitors Helen S Goodridge, PhD helen.goodridge@csmc.edu Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, USA Fondation
More informationOutline. Case Study 5/17/2010. Treating Lower-Risk Myelodysplastic Syndrome (MDS) Tapan M. Kadia, MD Department of Leukemia MD Anderson Cancer Center
Treating Lower-Risk Myelodysplastic Syndrome (MDS) Tapan M. Kadia, MD Department of Leukemia MD Anderson Cancer Center Outline Case Study What is lower-risk MDS? Classification systems Prognosis Treatment
More informationLiving with PNH 7/3/2013. Paroxysmal Nocturnal Hemoglobinuria (PNH): A Chronic, Systemic, and Life- Threatening Disease
Living with PNH Laurence A. Boxer, MD University of Michigan Case Study 15 year old awakened in the morning with chest pain and a sore throat. She experienced chest pain all day accompanied with coughing
More informationJoint meeting ADWP & SAAWP November 2016, Paris, France
, Preliminary Programme 09 November - ADWP Educational 10:00-10:30 Welcome & coffee 1 st session Connective tissue diseases Chair: David Kiely & Renate Arnold 10:30-10:50 How do we make HSCT for SSc safer?
More informationERROR CORRECTION FORM
Juvenile Idiopathic Arthritis Pre-HSCT Data Sequence Number: Registry Use Only Date of HSCT for which this form is being completed: HSCT type: autologous allogeneic, allogeneic, syngeneic unrelated related
More informationAplastic anemia. Case report. Effect of antithymocyte globulin on erythroid colony formation
Case report Aplastic anemia Effect of antithymocyte globulin on erythroid colony formation Susan A. Rothmann Hamburger, Ph.D. Department of Laboratory Hematology and Blood Banking James H. Finke, Ph.D.
More informationLate Complications Following Treatment for Severe Aplastic Anemia (SAA) with High-Dose Cyclophosphamide (Cy): Follow up of a Randomized Trial
Blood First Edition Paper, prepublished online June 28, 2002; DOI 10.1182/blood-2002-02-0494 Late Complications Following Treatment for Severe Aplastic Anemia (SAA) with High-Dose Cyclophosphamide (Cy):
More informationThe g c Family of Cytokines Prof. Warren J. Leonard M.D.
The Family of Cytokines Chief, Laboratory of Molecular Immunology Director, Immunology Center National Heart, Lung, and Blood Institute National Institutes of Health Department of Health and Human Services
More information2018 KSMO Immune Oncology Forum. Immune checkpoint inhibitors in hematologic. malignancies: evidences and perspectives 서울아산병원종양내과 홍정용
2018 KSMO Immune Oncology Forum Immune checkpoint inhibitors in hematologic malignancies: evidences and perspectives 서울아산병원종양내과 홍정용 2018-07-18 Contents Introduction Immune checkpoint inhibtors in lymphomas
More informationCIBMTR Center Number: CIBMTR Recipient ID: RETIRED. Today s Date: Date of HSCT for which this form is being completed:
Juvenile Idiopathic Arthritis Pre-HSCT Data Sequence Number: Date Received: Registry Use Only Today s Date: Date of HSCT for which this form is being completed: HSCT type: autologous allogeneic, allogeneic,
More informationAplastic Anaemia Genomics: Current data and interpretation
An Academic Health Sciences Centre at the heart of a world city... Aplastic Anaemia Genomics: Current data and interpretation Austin G Kulasekararaj Consultant Haematologist King s College Hospital, London
More informationEffect of Interleukin 10 on the Hematopoietic Progenitor Cells from Patients with Aplastic Anemia
Effect of Interleukin 10 on the Hematopoietic Progenitor Cells from Patients with Aplastic Anemia YOSHINOBU ASANO, SHOICHIRO SHIBATA, SHINJI KOBAYASHI, SEIICHI OKAMURA, YOSHIYUKI NIHO First Department
More informationSubject: Hematopoietic Stem Cell Transplantation for Aplastic Anemia. Revision Date(s):
Subject: Hematopoietic Stem Cell Transplantation for Aplastic Anemia Guidance Number: Medical Coverage Guidance Approval Date: 6/26/13 MCG-143 Revision Date(s): Original Effective Date:6/26/13 PREFACE
More information