Development and Characterization of Lipid Nanoparticles prepared by Miniemulsion Technique
|
|
- Poppy Kennedy
- 5 years ago
- Views:
Transcription
1 Development and Characterization of Lipid Nanoparticles prepared by Miniemulsion Technique Clara Patrícia Andrade Lopes Instituto Superior Técnico, Universidade de Lisboa, Portugal Abstract: In the present work a MCFA SLNs and NLCs based on a combination of MCFA and natural oil were successfully prepared by sonication technique and employing a nonionic surfactant. The two anti-tb drugs, rifampicin and pyrazinamide, are entrapped into obtained lipid nanoparticles. The developed particles were characterized in terms of particle size, polydispersity index, zeta potential, morphology and encapsulation efficiency. Mean particle size of all formulations ranged between 69 ± 5 nm to 601 ± 100 nm, showing a suitable size for oral administration. The zeta potential obtained was negatively enough to ensure a good physical stability of the particles. Morphological studies by TEM showed spherical to oval SLNs and RIF-NLCs with well-defined periphery. The rifampicin encapsulation efficiency ranges between 67 ± 7% and 85 ± 5%, while pyrazinamide encapsulation efficiency ranges between 14 ± 8% to 29±15%. In conclusion, despite being essential several further studies to ensure the efficacy of obtained lipid nanoparticles, the results from the present work pose a strong argument for lipid nanoparticles as a promising strategy for the oral delivery of anti-tb drugs. Keywords: Oral administration; Solid lipid nanoparticles; Rifampicin; Pyrazinamide Introduction Apart from some particular situations, the oral route is the first choice for drug administration. This preference is related with its easy access and non-invasive nature, which improves patient compliance and, therefore, facilitates treatments. However, the poor water solubility of several drug molecules and/or the risk of degradation throughout the gastrointestinal tract, turn into impossible their oral administration. In this perspective, efforts have been done in order to improve the oral bioavailability of poorly water-soluble drugs, by means of developing new colloidal delivery carriers. Among these systems are lipid nanoparticles, which have been showing promising results. The main reason for this is related with the wellknown conception that lipids promote oral drug absorption, because they undergo the same physiological mechanisms of food lipid digestion [1]. Lipid nanoparticles also offer unique properties such as small size, large surface area, increased drug loading and stability (especially for lipophilic drugs), 1
2 possibility of controlled drug release, no toxicity and high bioavailability [2]. Therefore, the first objective of the present work was to perform the production, characterization and study of a MCFA SLNs and MCFA/natural oil NCLs prepared by sonication and employing a nonionic surfactant. The second objective of the project was to study the obtained SLNs and NCLs as an alternative system to improve the oral delivery of two anti-tb drugs, rifampicin and pyrazinamide. Materials Rifampicin and Pyrazinamide were purchased from Sigma-Aldrich. The Hexadecane 99% (Mw= g/mol; ρ= g/ml) was obtained from Sigma- Aldrich. Water from a Millipore Milli-Q ultrapure water purification unit was used. Methods Preparation of Lipid Nanoparticle Lipid nanoparticles were prepared by ultrasonication and simple magnetic stirring methods. Both aqueous and lipid phases are separately prepared before mixing. The aqueous phase is composed of water ( 80.0% w/w), non-ionic surfactant ( 8.0% w/w) and hexadecane ( 3.5% w/w). Six formulations of empty SLNs was prepared ranging lipid content: SLN_1 represents the formulation with the lowest lipid phase content and SLN_6 represents the formulation with the highest lipid phase content. For NLC formulations was used a combination of natural oil with the MCFA. The content of bioactive compounds incorporated in lipid nanoparticles are shown at Table 1. Table 1 - Composition % (w/w) of bioactive compounds loaded to lipid nanoparticles. Formulation β RIF PYZ 2RIF_SLN RIF_NLC RIF_SLN RIF_NLC RIF_SLN RIF_NLC PYZ_SLN PYZ_NLC β10-sln β10-nlc In detail, the lipids are melted in a warm water bath above their melting points. Different temperatures conditions were tested up than 50ºC. When the MCFA or the MCFA/natural oil combination was fully melt a hot aqueous solution with nonionic surfactant and hexadecane preheated at the same conditions was added. A hot coarse o/w was obtained under magnetic stirring at 750 rpm for 1min and was subjected to sonication using a probe (MS72) sonicator (Bandelin, Germany) during 5 minutes. Hot o/w emulsion was allowed to cool to room temperature under magnetic stirring at 750 rpm to obtain the lipid nanoparticles. After 2h, the samples of each formulation were stored both in a refrigerator at 4ºC and at room temperature. Some aqueous samples of lipid nanoparticles were fast frozen under 80 C in a deep freeze for 5h in ultra-low refrigerator. Then, the samples were moved 2
3 to the freeze-drier (Christ Alpha 1-2 LD) during 48h in order to get powder of lipid nanoparticles. For active agents-loaded lipid nanoparticles, the active agent was added to the lipid phase, 15 minutes earlier the addition of aqueous solution. Lipid Nanoparticles Characterization Particle Size Zetasizer Nano ZS, Malvern Instruments (Malvern, UK) was used to measure the size of lipid nanoparticles produced. Particle size measurements were made in disposable cells at 25 C, by non-invasive back scatter, with dynamic light scattering detected at an angle of ml of samples were used and 1:10 dilutions were performed to avoid multiple scattering phenomenon. All measurements are performed in triplicate with 20 runs per measurement. Zeta Potential Zeta potential measurements were also performed using a Malvern Zetasizer Nano ZS, Malvern Instruments (Malvern, UK) at 25ºC. The samples were diluted 1:10 in ultrapure Milli-Q water and placed at a folded capillary cell (DTS1060) where an alternating voltage of ±150mV was applied. All measurements are performed in triplicate with 20 runs per measurement. Particle Morphology Morphological observations were performed using a transmission electron microscope (TEM). 20 µl of samples previous analysed by DLS was deposited over a carbon covered TEM copper grid and then dried at room temperature. TEM images were collected using a microscope H-8100 Hitachi, operated with 200 kv of acceleration voltage incorporated with a CCD MegaView II bottom-mounted camera. Encapsulation Efficiency An indirect method was used to determine the encapsulation efficiency using the following equation: EE% = TD FD TD 100 where TD is total drug weighted at the beginning and FD is the free drug dissolved in aqueous medium. The amount of active agents in the supernatant was determined from its absorption using a double beam UV VIS spectrophotometer (Model U-2000, Hitachi) and 1cm quartz cells. The measures of absorbance were done at 333 nm for rifampicin and at 548 nm for β-carotene. Pyrazinamide was analysed based on the formation of a coloured complex between the drug and sodium nitroprusside at alkaline ph with a mixing ratios of 4:1, which could be measured at 495nm. The solution of sodium nitroprusside at alkaline ph was prepared mixing a solution of 2% sodium nitroprusside in milli-q water with a 2N sodium hydroxide solution in a ratio of 1:1 [3]. Calibration curves of rifampicin, pyrazinamide and β-carotene were obtained by measuring solutions with known concentrations of the active compounds dissolved in milli-q water. Samples were estimated in triplicates. Resulting calibration curves and respective equations are represented in Figure
4 Figure 1 - Rifampicin calibration curve Figure 2 - β-carotene calibration curve Figure 3 - Pyrazinamide calibration curve Results and Discussion Study of Fabrication Parameters The greatest advantage of ultrasonication is the easily production of SLNs without using organic solvents. The droplet size is governed by energy dissipation, temperature, surfactant and lipid concentration and other factors. Nonionic surfactant was employed, providing a steric hindrance, avoiding emulsion droplets from coming close to each other and thus preventing flocculation and coalescence. It was tested the influence of different parameters, such as applied lipid amount, temperature and sonication step on mean particle size expressed as Z-average mean size (Z-ave), polydispersity index (PDI) and zeta potential (ZP) (Table 2, Figure 4 and Figure 5) The lipid nanoparticles obtained are suitable carrier systems for the incorporation of different bioactive compounds intended for oral administration, since mean particle size of all formulations ranged from 69 ± 5 nm to 601 ± 100 nm and the great part of the formulations revealed a particle size less than 400 nm, which easily cross intestinal cells [4]. Also, it was obtained a lot of formulations with a particle size less than 200 nm, which is an even better result since they will remain invisible to the reticulo-endothelial system (RES) and keep on circulation system over a prolonged period of time [5]. The Zeta Potential obtained was negatively enough to ensure a good physical stability of the particles, indicating that the nonionic surfactant is a good surfactant for lipid nanoparticles produced with this particular formulation. In general, the formulations show a PDI higher than 0.1, indicating that none are monodisperse. 4
5 Table 2 - Physicochemical characteristics of empty SLN at different conditions (mean ± SD, n = 6). T (ºC) A B C D Non-sonicated Sonicated Formulation Z-Ave Z-Ave PdI ZP (mv) (d.nm) (d.nm) PdI ZP (mv) SLN_1 601 ± ± ± ± ± ± 0.7 SLN_2 250 ± ± ± ± ± ± 1.5 SLN_3 224 ± ± ± ± ± ± 0.8 SLN_4 284 ± ± ± ± ± ± 0.7 SLN_5 249 ± ± ± ± ± ± 0.6 SLN_6 326 ± ± ± ± ± ± 1.2 SLN_1 299 ± ± ± ± ± ± 2.0 SLN_2 262 ± ± ± ± ± ± 1.0 SLN_3 231 ± ± ± ± ± ± 0.7 SLN_4 255 ± ± ± ± ± ± 0.6 SLN_5 411 ± ± ± ± ± ± 0.9 SLN_6 330 ± ± ± ± ± ± 0.9 SLN_1 515 ± ± ± ± ± ± 0.8 SLN_2 155 ± ± ± ± ± ± 0.9 SLN_3 140 ± ± ± ± ± ± 1.0 SLN_4 196 ± ± ± ± ± ± 0.6 SLN_5 149 ± ± ± ± ± ± 3.9 SLN_6 179 ± ± ± ± ± ± 0.7 SLN_1 333 ± ± ± ± ± ± 0.6 SLN_2 93 ± ± ± ± ± ± 0.7 SLN_3 144 ± ± ± ± ± ± 0.6 SLN_4 90 ± ± ± ± ± ± 0.7 SLN_5 99 ± ± ± ± ± ± 1.0 SLN_6 121 ± ± ± ± ± ± 0.2 Table 2 shows a notorious size reduction of non-sonicated particles with the increase of temperature, while PDI and ZP values remain with non-significant variation. These results are expected since in general, the increase of temperature usually decreases the viscosity of the lipid and aqueous phases and hence the efficiency of the agitation and mixture is increased. In other words, increasing the fusion temperature of the lipids results in smaller droplet/particle sizes [6]. From analysis of non-sonicated samples of a, c and d in Figure 4, it seems evident that particle size of SLNs prepared with the lowest concentration of MCFA are larger when compared with other SLNs. In addition, PDI of these samples are also high. However, ZP appears not be affected as well as all features considered of lipid particles obtained by sonication. As PDI of non-sonicated SLNs produced with lowest lipid content are also very high, the Ostwald ripening effects could be an explanation for their larger sizes. 5
6 Figure 4- Z-ave and PDI of empty SLNs with different content of MCFA (SLN_1 represents the lowest lipid phase content and SLN_6 represents the highest lipid phase content), ranging from a lowest temperature (a) to highest temperature (d). Figure 5 - Zeta Potential of empty SLNs with different content of MCFA (SLN_1 represents the lowest lipid phase content and SLN_6 represents the highest lipid phase content), ranging from a lowest temperature (a) to highest temperature (d). 6
7 At Figure 4, it is clear the effect of sonication in both Z-ave and PDI of MCFA SLNs. All sonicated SLNs show a mean Z- ave lower than 150 nm. Despite of this significant effect on particle size, ultrasonication does not appear to play an essential role in physical stability of SLNs, since ZP is very similar between nonsonicated and sonicated SLNs, although there is an insignificant decrease in absolute ZP value (Figure 5). The reduction effect of sonication at particle size is also visible by macroscopic aspect. It is possible to see at Figure 6 that nonsonicated SLNs dispersion has a milky aspect, while sonicated SLNs dispersion are more clear and bluish. From literature, usually colloidal dispersions with droplet sizes between nm are transparent or bluish, while colloidal dispersions with larger droplets sizes up to 500 nm has a milky aspect [7]. Figure 6 - Macroscopic aspect of empty SLNs: (left) - non-sonicated sample; (right) sonicated sample. Examining particle size distribution of SLN_1b_II before and after lyophilisation (Figure 7), it is possible to realize the appearance of a second particles population larger than 1 µm in reconstituted lyophilised sample. This larger population could be result of aggregation phenomenon, indicating physical instability of SLNs. However, another explanation for these results could be an insufficient stirring force/time applied on resuspension of lyophilised SLNs in milli-q water. To explore this hypothesis, it could be done a comparative study between different forces used to resuspension of lyophilised SLNs. In addition, it could be also investigated the combination of a cryoprotector previously to lyophilisation since it was found that cryoprotective agents preserve the physicochemical properties of SLNs and decrease SLNs aggregation. [8]. An example of a macroscopic milky-like colloidal SLNs dispersion stored at room temperature was also analysed. The mean particle size remained lower than 400 nm, although there was an increasing on the size (Figure 8). Since PDI and particle size remain relatively low, homogeneously sized SLNs displayed a satisfactory long-term stability. The shape and surface morphology of empty SLNs after seven months were also analysed by TEM and the resulting images are represented in Figure 9. All the particles were found to be smoothly spherical or oval in shape with a welldefined periphery. 7
8 Figure 7 - Particle Size Distribution by Intensity of SLN_1b_II before and after lyophilisation. Figure 8 - Particle Size Distribution by Intensity of SLN_4b_I after one day and 7 months after production. Figure 9 - TEM image of SLN_4b_I after 7 months. Bioactive Compounds Loaded SLNs and NLCs β-carotene Comparing with rifampicin and pyrazinamide loaded-particles, β-carotene shows the highest percentage of encapsulation efficiency (Table 3). This result was predictable, since β-carotene is the most lipophilic of these three active compounds. Also, since β-carotene is less soluble in oil then in fat, the %EE of β10- SLN is higher than β10-nlc. Rifampicin As expected RIF-NLCs samples are larger than RIF-SLNs (Table 3). In addition, RIF loaded particles show a reduction in the electrical charge at the surface to mean values below -20 mv. These results could be taken as an indication that RIF is entrapped in the lipid matrix. Due to the high solubility of RIF in the lipid core, the encapsulation efficiency was good enough for all the formulations, ranging between 67 ± 7% and 85 ± 5%. RIF-NLCs also exhibit a spherical shape, which indicates drug loading is not lead to morphological changes (Figure 10). From literature, it was found two studies involving the encapsulation of RIF in lipid nanoparticles. In first one, RIF was loaded into Compritol ATO 888 SLNs fabricated by a modified microemulsion technique. The particles sizes obtained were 141 ± 13nm, ZP value was 3.5 ± 0.8mV and %EE was 65 ± 3% [9]. In second one, RIF was encapsulated in group with pyrazinamide and isoniazid in a stearic acid SLNs produced by emulsion solvent diffusion with a %EE of 51 ± 5% [10]. Perhaps due to RIF was been encapsulated combined with other anti-t 8
9 Table 3 - Physicochemical characteristics of the loaded lipid nanoparticles (mean ± SD, n = 3). Formulation Z-Ave ZP EE PDI (nm) (mv) (%) β10-sln 281 ± ± ± 5 95 ± 5 β10-nlc 328 ± ± ± 3 83 ± 6 2RIF_SLN 341 ± ± ± ± 10 2RIF_NLC 391 ± ± ± ± 7 Figure 10 - TEM image of rifampicin loaded NLC. 4RIF_SLN 84 ± ± ± ± 1 4RIF_NLC 180 ± ± ± ± 1 7RIF_SLN 181 ± ± ± ± 7 7RIF_NLC 215 ± ± ± ± 5 4PYZ-SLN 217 ± ± ± ± 8 4PYZ-NLC 313 ± ± ± ± 15 Figure 11 - TEM image of rifampicin loaded NLC. drugs the %EE was significant lower than results described in this work. Pyrazinamide The results of Z-ave, PDI, ZP and %EE of pyrazinamide loaded lipid nanoparticles are represented in Table 3. The %EE value obtained range from 14 ± 8% for PYZ-SLN to 29±15% for PYZ-NLC. These low results are expected since pyrazinamide is the most hydrophilic compound in that study. Thus, pyrazinamide partitioned between the melted lipid and aqueous phase. Since pyrazinamide is one of anti-tb drugs administered in current chemotherapy, in further studies could be investigated the combine incorporation of pyrazinamide with other anti-tb drugs such as rifampicin, isoniazid or ethambutol. Furthermore, the process of cooling from high to room temperature could be optimized in order to control crystallization processes and consequently the encapsulation efficiency. Pyrazinamide TEM images revealed nanoparticles with poorly spherical shapes. It was also reported the presence of aggregates, indicating important alterations on PYZ loaded particles structure (Figure 11). Conclusion MCFA SLNs and NCLs based on MCFA and natural oil were successfully prepared by sonication technique. This technique was simple, reproducible, prepared nanoparticles without the need of organic solvents or any sophisticated instruments and has the potential to easily scale up for large scale production. Also, rifampicin and pyrazinamide are successful incorporated 9
10 in obtained lipid nanoparticles. Therefore, despite must be done several further studies to ensure the efficacy of obtained lipid nanoparticles as drug delivery system for oral route, these initial results are very promising. References [1] Muchow M, Maincent P, Muller RH (2008) Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery. Drug Dev. Ind. Pharm. 34, [2] Müller RH, Mäder K, Gohla S (2000) Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur. J. Pharm. Biopharm. 50, [3] Gurumurthy P, Nair NG, Sarma GR (1980) Methods for the estimation of pyrazinamide and pyrazinoic acid in body fluids. Indian J. Med. Res. 71, [4] Hyuk Suh W, Suslick S, Stucky D, Suh Y-H (2009) Nanotechnology, nanotoxicology, and neuroscience. Pro Neurobiol 87, [5] Bhandari R, Kaur IP (2013) Pharmacokinetics, tissue distribution and relative bioavailability of isoniazid-solid lipid nanoparticles. Int. J. Pharm. 441, [6] Parhi R, Suresh P (2012) Preparation and characterization of solid lipid nanoparticles-a review. Curr. Drug Discov. Technol. 9, [7] Sadtler V, Galindo-alvarez JM, Bégué EM, Gemico P, Université C, Cnrs-ens-upmc UMR, Supérieure EN (2008) Low Energy Emulsification Methods for Nanoparticles Synthesis. [8] Schwarz C, Mehnert W (1997) Freeze-drying of drug-free and drug-loaded solid lipid nanoparticles. Int. J. Pharm. 157, [9] Singh H, Bhandari R, Kaur IP (2013) Encapsulation of Rifampicin in a solid lipid nanoparticulate system to limit its degradation and interaction with Isoniazid at acidic ph. Int. J. Pharm. 446, [10] Pandey R, Sharma S, Khuller GK (2005) Oral solid lipid nanoparticle-based antitubercular chemotherapy. Tuberculosis (Edinb). 85,
Formulation and Evaluation of Solid lipid nanoparticles: Isoniazid
129 Research Article Formulation and Evaluation of Solid lipid nanoparticles: Isoniazid Umatiya Imran*, Chintan Aundhia, A.K.Seth, Sachin Chauhan, Nirmal Shah Department of pharmacy, Sumandeep Vidhyapeeth
More informationPreparation and Characterization of Candesartan Cilexetil Solid Lipid Nanoparticulate Capsules
Research Article Preparation and Characterization of Candesartan Cilexetil Solid Lipid Nanoparticulate Capsules *Surya Kiran Vuddisa, Subramanian S., Sindhu Raavi Department of Pharmaceutics, PSG College
More informationDEVELOPMENT OF SOLID LIPID NANOPARTICLES OF A WATER SOLUBLE DRUG
Page4813 Indo American Journal of Pharmaceutical Research, 2016 ISSN NO: 2231-6876 DEVELOPMENT OF SOLID LIPID NANOPARTICLES OF A WATER SOLUBLE DRUG Akkshata Parab*, Amrita Bajaj Department of Pharmaceutics,
More informationOptimisation and Stability Assessment of Solid Lipid Nanoparticles using Particle Size and Zeta Potential
Journal of Physical Science, Vol. 25(1), 59 75, 2014 Optimisation and Stability Assessment of Solid Lipid Nanoparticles using Particle Size and Zeta Potential Rohan Shah, * Daniel Eldridge, Enzo Palombo
More informationFormulation and Evaluation of Nanostructured Lipid Carrier (NLC) For Glimepiride
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (7):251-256 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationTHE INFLUENCE OF OILS AND SURFACTANTS ON THE FORMATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) CONTAINING THERAPEUTIC PROTEIN
MATERIALS SCIENCE and TECHNOLOGY Edited by Evvy Kartini et.al. THE INFLUENCE OF OILS AND SURFACTANTS ON THE FORMATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) CONTAINING THERAPEUTIC PROTEIN
More informationStudies on the cyclosporin A loaded stearic acid nanoparticles
International Journal of Pharmaceutics 200 (2000) 153 159 www.elsevier.com/locate/ijpharm Studies on the cyclosporin A loaded stearic acid Qiang Zhang a, Guoqing Yie a, Yie Li a, Qingsong Yang a, T. Nagai
More information7. SUMMARY, CONCLUSION AND RECOMMENDATIONS
211 7. SUMMARY, CONCLUSION AND RECOMMENDATIONS Drug absorption from the gastro intestinal tract can be limited by various factors with the most common one being poor aqueous solubility and poor permeability
More informationEffect of Surfactant Concentration on the Particle Size, Stability and Potential Zeta of Beta carotene Nano Lipid Carrier
ISSN: 2319-7706 Volume 4 Number 9 (2015) pp. 924-932 http://www.ijcmas.com Original Research Article Effect of Surfactant Concentration on the Particle Size, Stability and Potential Zeta of Beta carotene
More informationTransparent Dispersions of Milk Fat-Based Solid Lipid Nanoparticles for Delivery of beta-carotene
University of Tennessee, Knoxville Trace: Tennessee Research and Creative Exchange Masters Theses Graduate School 8-2013 Transparent Dispersions of Milk Fat-Based Solid Lipid Nanoparticles for Delivery
More informationThatipamula RP., Palem CR., Gannu R., Mudragada S., * Yamsani MR.
23 Thatipamula RP., Palem CR., Gannu R., Mudragada S., * Yamsani MR. Received 8 Sept 2010 Revised 30 Jan 2011 Accepted 2 Feb 2011 Domperidone (DOM) is a dopamine- receptor (D 2 ) antagonist, widely used
More informationPREPARATION AND CHARACTERIZATION OF LORNOXICAM LOADED SOLID LIPID NANOPARTICLES MADE FROM DIFFERENT LIPIDS
Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 5, Suppl 4, 2013 Research Article PREPARATION AND CHARACTERIZATION OF LORNOXICAM LOADED SOLID LIPID NANOPARTICLES
More informationDEVELOPMENT AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES BY SOLVENT DIFFUSION- EVAPORATION METHOD FOR TOPICAL DELIVERY
IJPSR (2014), Vol. 5, Issue 3 (Research Article) Received on 24 September, 2013; received in revised form, 10 December, 2013; accepted, 17 February, 2014; published 01 March, 2014 DEVELOPMENT AND CHARACTERIZATION
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2013, 4(3):8-13 ISSN: 0976-8688 CODEN (USA): PSHIBD Compritrol ATO 888 based solid lipid nanoparticles of cefixime: Formulation
More informationEmulsions. Purpose of emulsions and of emulsification:
Pharmacist Ghada Hamid Emulsions Emulsion is a dispersion in which the dispersed phase is composed of small globules of a liquid distributed throughout a vehicle in which it is immiscible. The dispersed
More informationPreparation and Evaluation of Nano-Structured Lipid Carriers of Azelaic Acid in Topical Formulation (Hydrogel)
Available online on www.ijcpr.com International Journal of Current Pharmaceutical Review and Research; (); -9 Research Article ISSN: 9 X Preparation and Evaluation of Nano-Structured Lipid Carriers of
More informationENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE
PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE Kantilal B. Narkhede *1, R. B. Laware 2, Y. P.
More informationPhysicochemical properties of nanostructured lipid carriers as colloidal carrier system stabilized with polysorbate 20 and polysorbate 80
African Journal of Biotechnology Vol. 10(9), pp. 1684-1689, 28 February, 2011 Available online at http://www.academicjournals.org/ajb DOI: 10.5897/AJB10.1667 ISSN 1684 5315 2011 Academic Journals Full
More informationEnhanced delivery methods for greater efficacy
On-Line Formulation Training - Anywhere In The World - Enhanced delivery methods for greater efficacy Belinda Carli Director, Institute of Personal Care Science Image showing absorbance in the outer stratum
More informationLiposomes in polymer matrix. Stability of liposomes in PEG 400 and PEG 8000 solutions.
Liposomes in polymer matrix. Stability of liposomes in PEG 400 and PEG 8000 solutions. Magdalena Bajgrowicz 1,2, Jerzy Detyna 2, Marek Langner 1 1 Institute of Biomedical Engineering and Instrumentation,
More informationBiopharmaceutics Dosage form factors influencing bioavailability Lec:5
Biopharmaceutics Dosage form factors influencing bioavailability Lec:5 Ali Y Ali BSc Pharmacy MSc Industrial Pharmaceutical Sciences Dept. of Pharmaceutics School of Pharmacy University of Sulaimani 09/01/2019
More informationPreparation, Characterization and In vivo Evaluation of Rosuvastatin Calcium Loaded Solid Lipid Nanoparticles
Suvarna et al: Preparation, Characterization and In vivo Evaluation of Rosuvastatin Calcium Loaded Solid Lipid Nanoparticles 2779 International Journal of Pharmaceutical Sciences and Nanotechnology Volume
More informationDevelopment of Nutrient Delivery Systems: Ingredients & Challenges
Development of Nutrient Delivery Systems David Julian McClements and Hang Xiao Department of Food Science University of Massachusetts Development of Nutrient Delivery Systems: Ingredients & Challenges
More informationEFFECT OF COMPRESSED CO 2 ON THE PROPERTIES OF AOT IN ISOOCTANE REVERSE MICELLAR SOLUTION AND ITS APPLICATION TO RECOVER NANOPARTICLES
EFFECT OF COMPRESSED CO 2 ON THE PROPERTIES OF AOT IN ISOOCTANE REVERSE MICELLAR SOLUTION AND ITS APPLICATION TO RECOVER NANOPARTICLES Dongxia Liu, Jianling Zhang, Tiancheng Mu, Jing Chen, Weize Wu, Jun
More informationFORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 974-434 Vol.2, No.1, pp 341-347, Jan-Mar 1 FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS Kothawade S. N. 1 *, Kadam
More informationAtorvastatin Loaded Solidlipid Nanoparticles: Formulation, Optimization, and in - vitro Characterization
IOSR Journal of Pharmacy ISSN: 2250-3013, www.iosrphr.org Volume 2 Issue 5 Sep-Oct 2012 PP.23-32 Atorvastatin Loaded Solidlipid Nanoparticles: Formulation, Optimization, and in - vitro Characterization
More information1. Gastric Emptying Time Anatomically, a swallowed drug rapidly reaches the stomach. Eventually, the stomach empties its content in the small
Lecture-5 1. Gastric Emptying Time Anatomically, a swallowed drug rapidly reaches the stomach. Eventually, the stomach empties its content in the small intestine. Because the duodenum has the greatest
More informationEffect of mole ratio on physicochemical properties of luteolin-loaded phytosome
2017; 6(12): 96-101 ISSN (E): 2277-7695 ISSN (P): 2349-8242 NAAS Rating 2017: 5.03 TPI 2017; 6(12): 96-101 2017 TPI www.thepharmajournal.com Received: 17-10-2017 Accepted: 18-11-2017 Cysilia K Hindarto
More informationCHAPTER 6. STABILITY STUDIES
Contents 6. INTRODUCTION... 148 6.1 Method... 148 6.3 Results and Discussion... 149 6.3.1 Stability Testing of RGD-grafted optimized Liposomes... 149 6.4 References... 151 Table of content Table 6 1Stability
More informationSuppository Chapter Content
10 min SUPPOSITORY Suppository Chapter Content 1. Suppositories and Factors Affecting Drug Absorption 2. Ideal Suppository and Different Types of Bases 3. Methods of Suppository Manufacturing Suppository
More informationB. semisolid materials consisting of hydrophilic and hydrophobic portions
CHEM 470 Understanding Emulsions I. Definitions A. Any heterogeneous system which has at least one immiscible or barely miscible liquid dispersed in another liquid in the form of tiny droplets. A. Becher,
More informationFluorescent Carbon Dots as Off-On Nanosensor for Ascorbic Acid
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2014 Fluorescent Carbon Dots as Off-On Nanosensor for Ascorbic Acid Jun Gong, Xin Lu, Xueqin An*
More informationDEVELOPMENT AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF A POORLY WATER SOLUBLE DRUG USING NATURAL OIL
Acta Poloniae Pharmaceutica ñ Drug Research, Vol. 69 No. 4 pp. 713ñ717, 2012 ISSN 0001-6837 Polish Pharmaceutical Society PHARMACEUTICAL TECHNOLOGY DEVELOPMENT AND CHARACTERIZATION OF SELF EMULSIFYING
More informationSupporting Information
Supporting Information Polymer Micelles Stabilization-n-Demand through Reversible Photocrosslinking 1. Synthesis and Characterization of Diblock Copolymers Materials. Cu(I)Br, 2-Bromo-2-methylpropionyl
More informationCOPYRIGHTED MATERIAL. Contents. xiv xv xvi. About the authors Preface Acknowledgments
About the authors Preface Acknowledgments 1 Introduction to spray drying 1 1.1 Introduction 1 1.2 Stage 1: Atomization 2 1.2.1 Principle of atomization 3 1.2.2 Classification of atomizers 4 1.2.2.1 Rotary
More informationEFFECT OF PVP ON CYCLODEXTRIN COMPLEXATION OF EFAVIRENZ FOR ENHANCING ITS SOLUBILITY AND DISSOLUTION RATE
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article EFFECT OF PVP ON CYCLODEXTRIN COMPLEXATION OF EFAVIRENZ FOR ENHANCING ITS SOLUBILITY AND DISSOLUTION
More information3.1 Background. Preformulation Studies
Preformulation Studies 3.1 Background Delivery of any drug requires a suitable dosage form to get optimum therapeutic effects. The development of such dosage forms fundamental properties of the drug molecule
More informationBEHAVIOUR OF EMULSIONS STABILIZED BY MAILLARD-BASED GLYCOCONJUGATES UNDER SIMULATED GASTROINTESTINAL CONDITIONS
BEHAVIOUR OF EMULSIONS STABILIZED BY MAILLARD-BASED GLYCOCONJUGATES UNDER SIMULATED GASTROINTESTINAL CONDITIONS U. Lesmes 1 and D. J. McClements 2 ABSTRACT 1 Department of Biotechnology and Food Engineering,
More informationMıCELLES AS NANOSıZED CARRıERS FOR SKıN DELıVERY OF DRUGS. Sevgi Güngör
MıCELLES AS NANOSıZED CARRıERS FOR SKıN DELıVERY OF DRUGS Sevgi Güngör Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology 4 th International Conference on Nanotek&Expo,01-03
More informationDesign, Development and Evaluation of Dry emulsion of Cephalexin Monohydrate
Research Article Design, Development and Evaluation of Dry emulsion of Cephalexin Monohydrate D. Madhuri*, K. Naga Raju, R. China Babu, SD. Baji Ruksana, B. Jyothsna, N. Vamsi Krishna, V. Lakshmi Dept
More informationFormulation and characterization of nanostructured lipid carrier encapsulated Zingiber zerumbet oil using ultrasonication technique
Formulation and characterization of nanostructured lipid carrier encapsulated Zingiber zerumbet oil using ultrasonication technique N. A. Rosli a, R. Hasham *, b, A. Abdul Aziz c and R. Aziz d Institute
More informationEFFECT OF SURFACE MODIFICATION OF SOLID LIPID NANOPARTICLES IN BRAIN TARGETING
EFFECT OF SURFACE MODIFICATION OF SOLID LIPID NANOPARTICLES IN BRAIN TARGETING THESIS SUBMITTED TO JAMIA HAMDARD (HAMDARD UNIVERSITY) IN FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF DOCTOR
More informationPreparation and Characteristics of Nanostructured Lipid Carrier (NLC) Loaded Red Ginger Extract Using High Pressure Homogenizer Method
Preparation and Characteristics of Nanostructured Lipid Carrier (NLC) Loaded Red Ginger Extract Using High Pressure Homogenizer Method Siti Sadiah 1,2,3*, Effionora Anwar 1, Mahdi Djufri 1, Umi Cahyaningsih
More informationTamoxifen Drug Loading Solid Lipid Nanoparticles Prepared by Hot High Pressure Homogenization Techniques
American Journal of Pharmacology and Toxicology 3 (3): 219-224, 2008 ISSN 1557-4962 2008 Science Publications Tamoxifen Drug Loading Solid Lipid Nanoparticles Prepared by Hot High Pressure Homogenization
More informationEffect of Organic Hydrocolloids on Quality of Seabuckthorn Beverages and Cosmetic Emulsions
EuroWorkS 2010, Potsdam Effect of Organic Hydrocolloids on Quality of Seabuckthorn Beverages and Cosmetic Emulsions Gerald Muschiolik* and Rüdiger Schrödter** *Food Innovation Consultant, Potsdam **Aroma
More informationCharacterization and Modification of Low Molecular Water-Soluble Chitosan for Pharmaceutical Application
Characterization and Modification of Low Molecular Water-Soluble Chitosan Bull. Korean Chem. Soc. 2003, Vol. 24, No. 9 1303 Characterization and Modification of Low Molecular Water-Soluble Chitosan for
More informationSupporting Information for. A Lipophilic Pt(IV) Oxaliplatin Derivative Enhances Antitumor activity
Supporting Information for A Lipophilic Pt(IV) Oxaliplatin Derivative Enhances Antitumor activity Aiman Abu Ammar, Raji Raveendran, Dan Gibson, Taher Nassar and Simon Benita* The Hebrew University of Jerusalem,
More informationFORMULATION AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES FOR TRANSDERMAL DELIVERY OF TESTOSTERONE
FORMULATION AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES FOR TRANSDERMAL DELIVERY OF TESTOSTERONE L. K. Omray TIT College of Pharmacy, Bhopal (M.P.) Pin- 462 021, India Email: lkomray@rediffmail.com
More informationFormulation and Evaluation of Acyclovir Liposomes
Krishna Mohan Chinnala and Rabinarayan Panigrahy., 217/ Formulation and evaluation of acyclovir RESEARCH ARTICLE International Research Journal of Pharmaceutical and Biosciences Pri -ISSN: 2394-5826 http://www.irjpbs.com
More informationCHAPTER 6 FUNCTIONAL PROPERTIES OF PROTEIN HYDROLYSATES
68 CHAPTER 6 FUNCTIONAL PROPERTIES OF PROTEIN HYDROLYSATES 6.1 INTRODUCTION Functional properties can be defined as the overall physicochemical properties of proteins in food systems during processing,
More informationSupporting Information. Maximizing the Supported Bilayer Phenomenon: LCP Liposomes Comprised Exclusively
S-1 Supporting Information Maximizing the Supported Bilayer Phenomenon: LCP Liposomes Comprised Exclusively of PEGylated Phospholipids for Enhanced Systemic and Lymphatic Delivery Matthew T. Haynes and
More informationColloid chemistry. Lecture 13: Emulsions
Colloid chemistry Lecture 13: Emulsions Emulsions food cosmetics pharmaceutics biological systems bituminous carpet (asphalt) etc. Emulsion suitable for intravenous injection. Balm: Water in oil emulsion
More informationFocused ultrasound a novel tool for liposome formulation
Focused ultrasound a novel tool for liposome formulation Introduction Liposomes are excellent carriers of active pharmaceutical ingredients and cosmetic agents. Their vesicular structure, housed by lipid
More informationAPPLIED CHEMISTRY SURFACE TENSION, SURFACTANTS TYPES OF SURFACTANTS & THEIR USES IN TEXTILE PROCESSING
APPLIED CHEMISTRY SURFACE TENSION, SURFACTANTS TYPES OF SURFACTANTS & THEIR USES IN TEXTILE PROCESSING Lecture No. 13 & 14 2 Surface Tension This property of liquids arises from the intermolecular forces
More informationNovel drug delivery system. Nanos-in-Micros
Novel drug delivery system Nanos-in-Micros Janne Raula The annual symposium of the Finnish Society of Physical Pharmacy February 9 th, 2012 Medicinal treatment Indications -Neurosurgery -General surgery
More informationChapter - V RESULTS AND DISCUSSION
Chapter - V RESULTS AND DISCUSSION ANALYTICAL STUDY SCANNING OF DRUG Pure Ketoconazole was scanned in phosphate buffer saline (PBS) ph 7.4 and 10% methanol between 200 nm and 400 nm using uv-visible spectrophotometer.
More informationSOLUBILITY OF FLURBIPROFEN AND TIMOLOL MALEATE IN DENSE CARBON DIOXIDE
SOLUBILITY OF FLURBIPROFEN AND TIMOLOL MALEATE IN DENSE CARBON DIOXIDE Patrícia Coimbra, Ana Rita C. Duarte*, Hermínio C. de Sousa, Catarina M.M. Duarte* * Instituto de Biologia Experimental e Tecnológica,
More information1.2 Nano- or microencapsulation as a rich source of delivery of functional components 3
1 Overview of Nano- and Microencapsulation for Foods 1 Hae-Soo Kwak 1.1 Introduction 1 1.2 Nano- or microencapsulation as a rich source of delivery of functional components 3 1.3 Wall materials used for
More informationINTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES
INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Formulation and evaluation of sustained released niosomes containing pregabalin P. Aravinth Kumar *, Ranjit Singh, K. Karthick and K.S.G. Arulkumaran KMCH
More informationCinnarizine loaded lipid based system: preparation, optimization and in-vitro evaluation
IOSR Journal of Pharmacy ISSN: 2250-3013, www.iosrphr.org Volume 2 Issue 5 Sep-Oct. 2012 PP.47-56 Cinnarizine loaded lipid based system: preparation, optimization and in-vitro evaluation Shubham Rai 1,
More informationJournal of Chemical and Pharmaceutical Research, 2018, 10(1): Research Article
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2018, 10(1):67-71 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Preparation and In vitro Evaluation of Solid Dispersion
More informationSELF-EMULSIFYING DRUG DELIVERY SYSTEMS: A REVIEW
SELF-EMULSIFYING DRUG DELIVERY SYSTEMS: A REVIEW Jamilur Reza* Department of Pharmacy University of Science and Technology Chittagong Abstract Self-emulsifying drug delivery systems (SEDDS) possess unparalleled
More informationStudy on Targeting and in vitro Anti-oxidation of Baicalin Solid Lipid Nanoparticles
Ping Y et al. Chinese Herbal Medicines, 212, 4(4): 335-339 335 Study on Targeting and in vitro Anti-oxidation of Baicalin Solid Lipid Nanoparticles PING Yang 1, YU Lian 1, HU Yan-qiu 1, MA Li-na 1, CAO
More informationPhospholipid-assisted formation and dispersion of aqueous nano-c 60
Phospholipid-assisted formation and dispersion of aqueous nano-c 60 Yanjing Chen and Geoffrey D. Bothun* Department of Chemical Engineering, University of Rhode Island, Kingston, RI, USA Introduction Water-soluble
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com COMPARARISSION OF SOLUBILITY IMPROVEMENT OF CEFIXIME
More informationNanopigments For Broad Spectrum Sun Protection. Patricia Aikens NAFTA Technical Services
Nanopigments For Broad Spectrum Sun Protection Patricia Aikens NAFTA Technical Services UV radiation and the skin UV absorbers Nanopigments Titanium dioxide Zinc Oxide Electromagnetic Radiation Longer
More informationFACTORIAL STUDIES ON THE EFFECTS OF HYDROXY PROPYL β- CYCLODEXTRIN AND POLOXAMER 407 ON THE SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUGS
JChrDD Vol 2 Issue 2 2011: 89-93 ISSN 2249-6785 Journal of Chronotherapy and Drug Delivery Received: August 06, 2011 Accepted: Sep 12, 2011 Original Research Paper FACTORIAL STUDIES ON THE EFFECTS OF HYDROXY
More informationThe Use of Emulsion Technology for Bioactive Delivery in Foods
The Use of Emulsion Technology for Bioactive Delivery in Foods By: Dr. Lisa Zychowski Emulsion-based delivery systems for bioactives are often employed in both the food and pharmaceutical industry. Emulsions,
More informationDhana Lakshmi P. et al. / International Journal of Biopharmaceutics. 2012; 3(2): International Journal of Biopharmaceutics
70 e- ISSN 0976-1047 Print ISSN 2229-7499 International Journal of Biopharmaceutics Journal homepage: www.ijbonline.com IJB SOLID LIPID NANOPARTICLE SYSTEMS FOR DELIVERY OF DRUGS TO THE BRAIN Dhana Lakshmi.
More informationSUPPLEMENTARY INFORMATION
SUPPLEMENTARY INFORMATION DOI: 10.1038/NNANO.2012.80 Protein-Inorganic Hybrid Nanoflowers Jun Ge, Jiandu Lei, and Richard N. Zare Supporting Online Material Materials Proteins including albumin from bovine
More informationLipid Nanoparticulate system of Simvastatin- A method for solubility enhancement
Research Article ISSN: 0974-6943 Akash C et al. / Journal of Pharmacy Research 2017,11(6), Available online through http://jprsolutions.info Lipid Nanoparticulate system of Simvastatin- A method for solubility
More informationFormulation, Characterization and In Vitro Skin Penetration of Green tea (Camellia sinensis L.) Leaves Extract-Loaded Solid Lipid Nanoparticles
Journal of Applied Pharmaceutical Science Vol. 8(08), pp 057-062, August, 2018 Available online at http://www.japsonline.com DOI: 10.7324/JAPS.2018.8809 ISSN 2231-3354 Formulation, Characterization and
More informationSupporting information
S1 Supporting information Biodegradable Injectable Polymer Systems Exhibiting Temperature-Responsive Irreversible Sol-to-Gel Transition by Covalent Bond Formation Yasuyuki YOSHIDA 1,2, Keisuke KAWAHARA
More informationA FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS
Research Article A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS K. P. R. Chowdary *, Tanniru Adinarayana, T. Vijay, Mercy. R. Prabhakhar
More informationMechanochemical Dry Conversion of Zinc Oxide to Zeolitic Imidazolate Framework
Mechanochemical Dry Conversion of Zinc Oxide to Zeolitic Imidazolate Framework Shunsuke Tanaka, *a,b Koji Kida, a Takuya Nagaoka, a Takehiro Ota a and Yoshikazu Miyake a,b a Department of Chemical, Energy
More informationAn introduction to Liposomal Encapsulation Technology
An introduction to Liposomal Encapsulation Technology Mother Nature has the innate ability to solve problems through the most efficient and effective route possible. The problem of how to make an oil-soluble
More informationDevelopment, characterization and evaluation of solid lipid nanoparticles as a potential anticancer drug delivery system
The University of Toledo The University of Toledo Digital Repository Theses and Dissertations 2012 Development, characterization and evaluation of solid lipid nanoparticles as a potential anticancer drug
More informationPRODUCTION OF VALUE ADDED PRODUCTS FROM SOME CEREAL MILLING BY-PRODUCTS SAYED SAAD ABOZAIED SMUDA THESIS DOCTOR OF PHILOSOPHY
PRODUCTION OF VALUE ADDED PRODUCTS FROM SOME CEREAL MILLING BY-PRODUCTS By SAYED SAAD ABOZAIED SMUDA B.Sc. Agric. Sci. (Food Science), Fac. Agric., Cairo Univ., 2004 M.Sc. Agric. Sci. (Food Science), Fac.
More informationSupporting information for the manuscript
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry A. This journal is The Royal Society of Chemistry 2014 Supporting information for the manuscript Toward enhanced photoactivity
More informationEncapsulation techniques
Loughborough University Institutional Repository Encapsulation techniques This item was submitted to Loughborough University's Institutional Repository by the/an author. Citation: VLADISAVLJEVIC, G.T.,
More informationLecipro AOCS Lecithin SC Montreal
Lecithin Dispersion and Emulsification Demo W. van Nieuwenhuyzen Lecipro Consulting www.lecipro.nl AOCS Lecithin SC - Montreal, April 27-28, 28, 2013 Lecipro AOCS Lecithin SC Montreal 2013 1 Topics Emulsifying
More informationDetermination of bioavailability
Pharmaceutics 2 Bioavailability Bioavailability is the rate and extent to which an administered drug reaches the systemic circulation. For example, if 100 mg of a drug is administered orally and 70 mg
More informationPreparation, Characterization and in vivo Evaluation of Felodipine Solid-Lipid Nanoparticles for Improved Oral Bioavailability
Gondrala et al: Preparation, Characterization and In vivo Evaluation of Felodipine Solid-Lipid Nanoparticles for 2995 International Journal of Pharmaceutical Sciences and Nanotechnology Research Paper
More informationTransdermal Delivery of Newer Atypical Antipsychotics ABSTRACT
Transdermal Delivery of Newer Atypical Antipsychotics ABSTRACT Abstract Risperidone and olanzapine, newer atypical antipsychotics are highly effective and safer in the treatment of psychosis. A low dose
More informationElectronic Supplementary Information
Electronic Supplementary Material (ESI) for Chemical Communications. This journal is The Royal Society of Chemistry 2015 Electronic Supplementary Information Enzymatic Synthesis and Post-Functionalization
More informationSokalan PA types. Sokalan PA 15 Sokalan PA 40. Sokalan PA 20 Sokalan PA 50. Sokalan PA 25 PN Granules Sokalan PA 80 S. Technical Information
Technical Information Sokalan PA types TI/ES 1151 e July 1992 (DFC) Supersedes TI/P 3037 e dated May 1988 Sokalan PA 13 PN Sokalan PA 30 CL Sokalan PA 15 Sokalan PA 40 Sokalan PA 20 PN Sokalan PA 40 Powder
More informationAvailable online at
Available online at www.jgtps.com Research Article ISSN:2230-7346 Journal of Global Trends in Pharmaceutical Sciences Vol.3, Issue 4, pp -923-928, October December 202 ENHANCEMENT OF DISSOLUTION RATE OF
More informationDevelopment, Characterization and In-Vitro Evaluation of Azithromycin Niosomes
Human Journals Research Article October 2018 Vol.:13, Issue:3 All rights are reserved by Senthil S.P et al. Development, Characterization and In-Vitro Evaluation of Azithromycin Niosomes Keywords: Azithromycin,
More informationFormulation of Redispersible Freeze-dried Emulsions. Gladness M. Manecka
Formulation of Redispersible Freeze-dried Emulsions Gladness M. Manecka 1 Introduction Stabilisation Destabilisation Oil Water Coalescence Flocculation Emulsifier + Homogenisation 2 Oil-in-water emulsion
More informationChemate and Chowdary, IJPSR, 2012; Vol. 3(7): ISSN:
IJPSR (2012), Vol. 3, Issue 07 (Research Article) Received on 18 March, 2012; received in revised form 25 April, 2012; accepted 22 June, 2012 A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION
More informationOPTIMIZATION OF PARTICLES SIZE FOR LUNG
OPTIMIZATION OF PARTICLES SIZE FOR LUNG SPECIFIC DRUG DELIVERY BY WAY OF MICROSPHERES Sree Harsha, Bandar E. Al-Dhubiab, Anroop B. Nair, Mohammed Al-Khars, Mohammed Al-Hassan, Raja Rajan, Mahesh Attimarad,
More informationSupporting Information
Electronic Supplementary Material (ESI) for Lab on a Chip. This journal is The Royal Society of Chemistry 2014 Supporting Information Three-dimensional Flash Flow Microreactor for Scale-up Production of
More informationNew Approaches on the Synthesis of Effective Nanostructured Lipid Carriers
New Approaches on the Synthesis of Effective Nanostructured Lipid Carriers ELENA MITREA 1,2, CRISTINA OTT 1 *, AURELIA MEGHEA 1 1 Politrhnica University Bucharest, Faculty of Applied Chemistry and Materials
More informationInsects as novel food ingredient
Insects as novel food ingredient Anne Louise Dannesboe Nielsen Team manager Food technology, DTI Insects in the food chain, Turku, 29/8-2017 Agenda About DTI food technology Insect as food Insects as ingredients
More informationSupporting Information
Supporting Information The Effects of Spacer Length and Composition on Aptamer-Mediated Cell-Specific Targeting with Nanoscale PEGylated Liposomal Doxorubicin Hang Xing +, [a] Ji Li +, [a] Weidong Xu,
More informationRESEARCH ARTICLE e-issn:
Available online at www.ijtpls.com International Journal of Trends in Pharmacy and Life Sciences Vol. 1, Issue: 5, 2015: 587-592 PREPARATION AND EVALUATION OF LIPOSOMES CONTAINING ZIDOVUDINE CH.B.V.V.L.S.Latha,KVR.
More informationFormulation and evaluation of novel sustained release multiple emulsion containing chemotherapeutic agents
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.4, No.2, pp 866-872, April-June 2012 Formulation and evaluation of novel sustained release multiple emulsion containing
More informationCHAPTER 1 INTRODUCTION
1 CHAPTER 1 INTRODUCTION 1.1 Background and Rationale Thailand has become the world's largest exporter of canned tuna and largest importer of fresh and frozen tuna. Canned tuna exports accounted for 77%
More informationChapter 3. Need for Present Study
Need for Present Study Chapter 3 Chemotherapy, the use of cytotoxic drugs to kill cancerous cells remains the most common approach for cancer therapy. In conventional chemotherapy most of the anticancer
More informationCholesterol determination using protein-templated fluorescent gold nanocluster probes
Electronic Supplementary Information for Cholesterol determination using protein-templated fluorescent gold nanocluster probes Xi Chen and Gary A. Baker* Department of Chemistry, University of Missouri-Columbia,
More information