BIOANALYTICAL ASSAY LIST
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1 GLP Bioanalytical Validated Methods (April 2010) Biological Analytical Matrix Technique 25-hydroxyvitamin D3 Monkey Serum 10 ng/ml 25-hydroxyvitamin D3 Rat Serum 2 ng/ml Acyclovir / Valacyclovir 20 ng/ml / 10 ng/ml Alendronate Human Urine Amphetamine / Lisdexamfetamine / Anastrozole 0. Armodafinil 100 ng/ml Aspirin / Dipyridamole 5 ng/ml / 20 ng/ml Atovaquone 2 ng/ml Atorvastatin / ortho-hydroxy Atorvastatin / para-hydroxy Atorvastatin 0.2 ng/ml Azacitidine 5 ng/ml Azathioprine / 6-Mercaptopurine 0.4 ng/ml / 0.4 ng/ml 2 ng/ml / Benazepril / Benazeprilat / 4 ng/ml / Hydrochlorothiazide 5 ng/ml Bicalutamide 10 ng/ml Budesonide / 6βhydroxybudesonide / 16α-hydroxyprednisolone 0. / Cabergoline 0.5 pg/ml Calcifediol Monkey Serum 10 ng/ml Calcifediol Rat Serum 2 ng/ml Cholecalciferol 0.25 ng/ml Cholecalciferol Cholecalciferol 2 ng/ml Cefpodoxime Dog Plasma 0. Ciprofloxacin 25 ng/ml 0.30 ng/ml / 0.30 ng/ml 0.30 ng/ml / 0.30 ng/ml / 0.30 ng/ml Human Urine Rabbit Plasma Rat Plasma 0.50 μg/ml / 0.05 μg/ml / 0.25 μg/ml / / / /
2 GLP Bioanalytical Validated Methods (April 2010) - continued Biological Analytical Matrix Technique Desglymidodrine Dialysate 0.14 ng/ml Desmopressin 4 pg/ml Dexlansoprazole 5 ng/ml Dextromethorphan / 0. / Midazolam 0. Diclofenac / Lidocaine Porcine Plasma 0. Diethylpropion Aspirin / Dipyridamole 5 ng/ml / 20 ng/ml Docetaxel 5 ng/ml Donepezil Doxylamine Entecavir 1 pg/ml Fenofibrate 10 ng/ml Fexofenadine Fexofenadine / Pseudoephedrine / 2 ng/ml Fluoxetine 0. Fluticasone Proprionate 3 pg/ml Formoterol fumarate 2 pg/ml Gabapentin 10 ng/ml Gemcitabine 200 ng/ml Ibandronate Lamotrigine 25 ng/ml Lansoprazole 2 ng/ml Leflunomide / A Leflunomide Metabolite 100 ng/ml Levetiracetam 100 ng/ml Lidocaine 0. Lisdexamfetamine / Amphetamine Methylphenidate 0. / 0. Modafinil 0.1 μg/ml R-modafinil 100 ng/ml Monensin Bovine Plasma 0.05 ng/ml Morphine / Morphine 3D-glucuronide (M3G) Morphine 6D-glucuronide (M6G) Nateglinide 100 ng/ml Niacin / Nicotinuric Acid / Nicotinamide *Drugs analyzed in the presence of each other are separated by a slash (/). 20 ng/ml / 5 ng/ml
3 GLP Bioanalytical Validated Methods (April 2010) - continued Biological Analytical Matrix Technique Niacin and Nicotinuric Acid Nilotinib 5 ng/ml Nitrazepam 0.25 ng/ml Nitroglycerin / 1,2-dinitroglycerin / 1,3-dinitroglycerin 20 pg/ml / 50 pg/ml / 50 pg/ml Olanzapine 0.2 ng/ml Olanzapine 0. Ondansetron 0.4 ng/ml Oxcarbazepine / 10, 11-dihydro- 10-hydroxycarbamazepine (MHD) Oxycodone / Noroxycodone / Oxymorphone 20 ng/ml / 200 ng/ml 0.25 ng/ml / ng/ml Paclitaxel 5 ng/ml Paliperidone ng/ml Penciclovir 20 ng/ml Phentermine / Topiramate 5 ng/ml Pregabalin 10 ng/ml Proguanil / Cycloguanil / 1-(4-Chlorophenyl) biguanide 0.2 ng/ml Pseudoephedrine 2 ng/ml Quinapril / Quinaprilat 4 ng/ml / 10 ng/ml Raloxifene 5 pg/ml Paclitaxel 5 ng/ml Paliperidone ng/ml Penciclovir 20 ng/ml Ribavirin 10 ng/ml Rifaximin** 0. Rifaximin** 0. Risperidone / 0. / 9-OH-Risperidone 0. Rivastigmine / 5 pg/ml / NAP pg/ml Rivastigmine / 0. / NAP ng/ml Rivastigmine / 0.05 ng/ml / LC-MS/MS NAP ng/ml Saquinavir 20 ng/ml Scopolamine 2 pg/ml *Drugs analyzed in the presence of each other are separated by a slash (/). **Limited Availability.
4 Sertraline / Norsertraline GLP Bioanalytical Validated Methods (April 2010) - continued Biological Matrix Analytical Technique 0.25 ng/ml / Sertraline 0.25 ng/ml Sulfamethoxazole / Trimethoprim 10 ng/ml Topiramate / Phentermine 5 ng/ml / 0.2 ng/ml Tramadol / 2ng/mL / O-desmethyltramadol Tranexamic Acid 50 ng/ml Trimethoprim / Sulfamethoxazole Valacyclovir / Acyclovir Venlafaxine and 4 metabolites (deuterated) Venlafaxine and 4 metabolites (deuterated) Verapamil / Norverapamil 10 ng/ml 20 ng/ml Rat Plasma Dog Plasma Vitamin D ng/ml Vitamin D3 Vitamin D3 2 ng/ml Voriconazole 10 ng/ml *Drugs analyzed in the presence of each other are separated by a slash (/).
5 Bioanalytical Methods Developed (April 2010) Biological Matrix Analytical Technique 1,25-Dihydroxyvitamin D2 25-Hydroxyvitamin D2 Aspirin / Dipyridamole Bupropion and Hydroxy-bupropion Codeine Dipyridamole / Aspirin Doxercalciferol Ethinyl Estradiol Floxuridine Fluvoxamine Lenalidomide Methotrexate Midazolam and metabolites Omega-3 Ethyl Esters Serum Phospholipid GC/FID Oxybutynin 16-α-prednisolone Human Urine Pyridoxine Risedronate Salinomycin Bovine Plasma *Drugs analyzed in the presence of each other are separated by a slash (/).
6 Bioanalytical Methods Under Development (April 2010) Biological Matrix Analytical Technique 5-aminosalicylic acid Aliskiren Calcitriol Monkey Serum Calcitriol Rat Serum Capacitibine Carbuterol Etravirine Fentanyl Imatinib Mecamylamine Memantine Mesalamine (Mesalazine, 5-ASA) Neridronate Omeprazole Pantoprazole Progesterone Quetiapine Rapamycin LC-MS/MS Sildenafil Strontium Ranelate ICP/MS Telmisartan *Drugs analyzed in the presence of each other are separated by a slash (/).
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