DRUG TREATMENT OF PARKINSON S DISEASE. Mr. D.Raju, M.pharm, Lecturer
|
|
- Byron Lyons
- 5 years ago
- Views:
Transcription
1 DRUG TREATMENT OF PARKINSON S DISEASE Mr. D.Raju, M.pharm, Lecturer
2 PARKINSON S DISEASE (parkinsonism) is a neurodegenerative disorder which affects t h e b a s a l g a n g l i a - and is associated with - a loss of dopaminergic neurons in the substantia nigra and - degeneration of nerve terminals in the striatum PARKINSON S SYNDROME is the adverse effect of antipsychotic agents due to D2-receptor blockade in the basal ganglia Its acute form is reversible
3 NEURODEGENERATIVE DISORDER The damage is caused by EXCITOTOXICITY OXIDATIVE STRESS APOPTOSIS /NECROSIS OF NEURONS EXCITOTOXICITY is due to: release of a high amount of glutamate intracellular Ca 2+ overload activation of NMDA, AMPA and metabotropic receptors activation of proteases and lipases (causing membrane damage)
4 Fig. 1a. Extrapyramidal motor system - Basal ganglia motor cortex glutamate MOVEMENT Corpus striatum glutamate dopamine ACH GABA GABA Substantia nigra (upraveno podle Rang-Dale, 1999)
5 Fig. 1b. Extrapyramidal motor system - Basal ganglia Neurodegeneration, Parkinson s disease motor cortex glutamate TREMOR RIGIDITY Corpus striatum ACH glutamate dopamine GABA GABA Substantia nigra neurodegeneration (upraveno podle Rang-Dale, 1999)
6 How to treat deficit of dopamine? Fig 2a. Synapsis of dopaminergic nigrostriatal neurons autoreceptorss MAO B levodopa D 2, D 3 - receptors dopamine
7 Fig 2b. Parkinson s disease treatment 6 agonists MAO B levodopa 1 3 dopamine
8 INCREASE IN DOPAMINERGIC ACTIVITY (1) dopamine precursors (replacement of dopamine) (2) MAO-B blockade (3) increase in dopamine release (4) blockade of amine neuronal reuptake (5) dopamine receptors agonists How to treat excitatory function of cholinergic and glutaminergic neurons? MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS
9 INCREASE IN DOPAMINERGIC ACTIVITY (1) dopamine precursors (replacement of dopamine) (2) MAO-B blockade (3) increase in dopamine release (4) blockade of amine neuronal reuptake (5) dopamine receptors agonists (6) presynaptic autoreceptor blockade
10 INCREASE IN DOPAMINERGIC ACTIVITY (1) dopamine precursors (replacement of dopamine) (2) MAO-B blockade (3) increase in dopamine release (4) blockade of amine neuronal reuptake (5) dopamine receptors agonists
11 Levodopa (L-DOPA) the first-line drug Dopa decarboxylase Levodopa dopamine Dopamine does not penetrate the blood-brain barrier. DOPA conversion to dopamine in the periphery, which would cause troublesome adverse effects is largely prevented by the decarboxylase inhibitor. Since the inhibitor does not penetrate the blood-brain barrier, decarboxylation occurs rapidly within the brain (95% of the levodopa dose).
12 LEVODOPA (L-DOPA) About 80% of parkinsonian patients show initial improvement with levodopa, particularly of rigidity and hypokinesia, and about 20% are restored virtually to normal motor function. Some symptoms (cognitive decline, dysphagia) are not improved. W i t h t i m e the effectiveness of levodopa gradually declines: it reflects: the natural progress of disease + receptor down-regulation
13 LEVODOPA (L-DOPA) Adverse effects (type A) dyskinesia - involuntary writhing movements develop in the majority of patients within 2 years of starting levodopa therapy : affect the face and limbs are dose-dependent (disappear if the dose is reduced) on-off effect rapid fluctuation in clinial state where hypokinesia and rigidity suddenly worsen (for anything from a few minutes to a few hours) and then improve again (probably the fluctuations reflect the changing plasma levodopa concentration) Others: nausea and anorexia, hypotension, by increase dopamine activity in the brain----schizophrenia-like syndrome with delusions and hallucinations confusion, disorientation, insomnia (in 20% of patients)
14 INCREASE IN DOPAMINERGIC ACTIVITY (1) dopamine precursors (replacement of dopamine) (2) MAO-B blockade (3) increase in dopamine release (4) blockade of amine neuronal reuptake (5) dopamine receptors agonists
15 MAO-B BLOCKADE Selegiline a selective inhibitor for MAO-B, which prediminates in dopamine containing regions in the CNS MAO-B inhibition: protects dopamine from intraneuronal degradation lacks the adverse peripheral effects of non-selective MAO inhibitors used to treat depression does not provoke the cheese reaction Combination of levodopa + selegilin is more effective in relieving symptoms and prolonging life
16 INCREASE IN DOPAMINERGIC ACTIVITY (1) dopamine precursors (replacement of dopamine) (2) MAO-B blockade (3) increase in dopamine release (4) blockade of amine neuronal reuptake (5) dopamine receptors agonists
17 DOPAMINE RECEPTORS AGONISTS-INCREASE IN DOPAMINE RELEASE- BLOCKADE OF AMINE NEURONAL REUPTAKE potent agonists at dopamine D2 receptors in the CNS: bromocriptine derived from the ergot alkaloids lisuride and pergolide amantadine increases dopamine release, activates D2 receptors less active, more tolerated
18 HOW TO TREAT EXCITATORY FUNCTION OF CHOLINERGIC AND GLUTAMINERGIC NEURONS? MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS atropine action is more limited (than that od levodopa): tremor is more diminished than rigidity or hypokinesia Adverse effects (type A- troublesome peripheral action): dry mouth, constipation, impaired vision, urinary retention benzatropine has less peripheral effect in relation to their central effect than does atropine
Drug Therapy of Parkinsonism. Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia
Drug Therapy of Parkinsonism Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia Parkinsonism is a progressive neurological disorder of muscle movement, usually
More informationHistory Parkinson`s disease. Parkinson's disease was first formally described in 1817 by a London physician named James Parkinson
Parkinsonismm History Parkinson`s disease Parkinson's disease was first formally described in 1817 by a London physician named James Parkinson Definition : Parkinsonism: Parkinsonism is a progressive neurological
More informationDrugs used in Parkinsonism
Drugs used in Parkinsonism قادة فريق علم األدوية : لي التميمي & عبدالرحمن ذكري الشكر موصول ألعضاء الفريق املتميزين : جومانة القحطاني ندى الصومالي روان سعد القحطاني pharma436@outlook.com @pharma436 Your
More informationParkinson s disease Therapeutic strategies. Surat Tanprawate, MD Division of Neurology University of Chiang Mai
Parkinson s disease Therapeutic strategies Surat Tanprawate, MD Division of Neurology University of Chiang Mai 1 Scope Modality of treatment Pathophysiology of PD and dopamine metabolism Drugs Are there
More informationMargo J Nell Dept Pharmacology
Margo J Nell Dept Pharmacology 1 The extra pyramidal system Separation of cortico-spinal system (pyramidal system, (PS)) from the basal ganglia (extra pyramidal motor system (EPS)) because they produce
More informationDrug Management of Parkinsonism. By Prof. Mohammad Saleh M. Hassan PhD. (Pharma); MSc. (Ped.); MHPE (Ed.)
Drug Management of Parkinsonism By Prof. Mohammad Saleh M. Hassan PhD. (Pharma); MSc. (Ped.); MHPE (Ed.) Drug management of Parkinsonism Levodopa Ergot derivatives noamine Oxidaes Inhibitors Catechol-Omethyl
More information- Neurotransmitters Of The Brain -
- Neurotransmitters Of The Brain - INTRODUCTION Synapsis: a specialized connection between two neurons that permits the transmission of signals in a one-way fashion (presynaptic postsynaptic). Types of
More informationDrugs Affecting the Central Nervous System
Asst Prof Inam S Arif isamalhaj@yahoo.com Drugs Affecting the Central Nervous System Ass Efferent neurons in ANS Neurodegenerative Diseases Parkinson s Disease Multiple Sclerosis Alzheimer s Disease
More informationParkinson's Disease. Robert L. Copeland, Ph.D. Howard University College of Medicine Department of Pharmacology
Parkinson's Disease Robert L. Copeland, Ph.D. Howard University College of Medicine Department of Pharmacology 18 February 2002 Parkinson Disease Neurological disease affecting over four million patients
More informationPharmacologic Treatment of Parkinson s Disease. Nicholas J. Silvestri, M.D. Assistant Professor of Neurology
+ Pharmacologic Treatment of Parkinson s Disease Nicholas J. Silvestri, M.D. Assistant Professor of Neurology + Overview n Brief review of Parkinson s disease (PD) n Clinical manifestations n Pathophysiology
More informationPARKINSON S MEDICATION
PARKINSON S MEDICATION History 1940 50 s Neurosurgeons operated on basal ganglia. Improved symptoms. 12% mortality 1960 s: Researchers identified low levels of dopamine caused Parkinson s leading to development
More informationTreatment of Parkinson s Disease and of Spasticity. Satpal Singh Pharmacology and Toxicology 3223 JSMBS
Treatment of Parkinson s Disease and of Spasticity Satpal Singh Pharmacology and Toxicology 3223 JSMBS singhs@buffalo.edu 716-829-2453 1 Disclosures NO SIGNIFICANT FINANCIAL, GENERAL, OR OBLIGATION INTERESTS
More information475 GERIATRIC PSYCHOPHARMACOLOGY (p.1)
475 GERIATRIC PSYCHOPHARMACOLOGY (p.1) I. General Information? Use lower doses? Start low and go slow? Expect prolonged elimination ½ lives? Expect sedative-hypnotics to be dementing, to impair cognitive
More informationChapter 20. Media Directory. Amyotrophic Lateral Sclerosis. Alzheimer s Disease. Huntington s Chorea. Multiple Sclerosis
Chapter 20 Drugs for Degenerative Diseases of the Nervous System Slide 18 Media Directory Levadopa Animation Upper Saddle River, New Jersey 07458 All rights reserved. Alzheimer s Disease Amyotrophic Lateral
More informationMovement Disorders: A Brief Overview
Movement Disorders: A Brief Overview Albert Hung, MD, PhD Massachusetts General Hospital Harvard Medical School August 17, 2006 Cardinal Features of Parkinsonism Tremor Rigidity Bradykinesia Postural imbalance
More informationDRUGS THAT ACT IN THE CNS
DRUGS THAT ACT IN THE CNS Drugs for Neurodegenerative Diseases 2 Dr Karamallah S. Mahmood PhD Clinical Pharmacology 1 DRUGS USED IN PARKINSON S DISEASE/ B. Selegiline and rasagiline Selegiline, also called
More informationNeurodegenerative diseases
Neurodegenerative diseases Hiwa K. Saaed, PhD Department of Pharmacology & Toxicology College of Pharmacy University of Sulaimani Hiwa.saaed@univsul.edu.iq 2018-19 Neurodegenerative diseases of the CNS
More informationPharmacologic Treatment of Parkinson s Disease. Nicholas J. Silvestri, M.D. Associate Professor of Neurology
+ Pharmacologic Treatment of Parkinson s Disease Nicholas J. Silvestri, M.D. Associate Professor of Neurology + Disclosures n NO SIGNIFICANT FINANCIAL, GENERAL, OR OBLIGATION INTERESTS TO REPORT + Learning
More informationPharmacology of Antiparkinsonian Agents
Pharmacology of Antiparkinsonian Agents Robert P. Soltis 1 College of Pharmacy and Health Sciences, Drake University, Des Moines I A 50311 PROLOGUE The following is a summary of a two hour class on the
More informationParkinson s Pharmacology
PHPP 517 (IT-III) Fall 2011 JACOBS Wed 10/12 8:00 8:50 AM 1 Learning objectives 1. Describe the direct and indirect pathways of the extrapyramidal system and its modulation by ACh and DA. 2. Contrast the
More informationParkinsonism or Parkinson s Disease I. Symptoms: Main disorder of movement. Named after, an English physician who described the then known, in 1817.
Parkinsonism or Parkinson s Disease I. Symptoms: Main disorder of movement. Named after, an English physician who described the then known, in 1817. Four (4) hallmark clinical signs: 1) Tremor: (Note -
More informationANTIPARKINSONIAN DRUGS. DRUGs ACT ON CNS (Pharmacology) Unit-5(8)
ANTIPARKINSONIAN DRUGS DRUGs ACT ON CNS (Pharmacology) Unit-5(8) Parkinsonism (PD) Extrapyramidal motor function disorder characterized by Rigidity Tremor Hypokinesia/Bradykinesia Impairment of postural
More informationBasal ganglia Sujata Sofat, class of 2009
Basal ganglia Sujata Sofat, class of 2009 Basal ganglia Objectives Describe the function of the Basal Ganglia in movement Define the BG components and their locations Describe the motor loop of the BG
More informationVL VA BASAL GANGLIA. FUNCTIONAl COMPONENTS. Function Component Deficits Start/initiation Basal Ganglia Spontan movements
BASAL GANGLIA Chris Cohan, Ph.D. Dept. of Pathology/Anat Sci University at Buffalo I) Overview How do Basal Ganglia affect movement Basal ganglia enhance cortical motor activity and facilitate movement.
More informationMaking Every Little Bit Count: Parkinson s Disease. SHP Neurobiology of Development and Disease
Making Every Little Bit Count: Parkinson s Disease SHP Neurobiology of Development and Disease Parkinson s Disease Initially described symptomatically by Dr. James Parkinson in 1817 in An Essay on the
More informationIntroductory Clinical Pharmacology Chapter 32 Antiparkinsonism Drugs
Introductory Clinical Pharmacology Chapter 32 Antiparkinsonism Drugs Dopaminergic Drugs: Actions Symptoms of parkinsonism are caused by depletion of dopamine in CNS Amantadine: makes more of dopamine available
More informationMedications used to treat Parkinson s disease
Medications used to treat Parkinson s disease Edwin B. George, M.D., Ph.D. Director of Wayne State University Movement Disorder Clinic University Health Center Neurology Clinic University Health The John
More informationMarch 2004 Parkinson s Disease H01
W-F Professional Associates, Inc. 400 Lake Cook Rd., Suite 207 Deerfield, IL 60015 847-945-8050 March 2004 Parkinson s Disease 707-000-04-003-H01 FLORIDA PHARMACISTS READ THIS VERY IMPORTANT CE BROKER
More information10th Medicine Review Course st July Prakash Kumar
10th Medicine Review Course 2018 21 st July 2018 Drug Therapy for Parkinson's disease Prakash Kumar National Neuroscience Institute Singapore General Hospital Sengkang General Hospital Singhealth Duke-NUS
More informationparts of the gastrointenstinal tract. At the end of April 2008, it was temporarily withdrawn from the US Market because of problems related to
parts of the gastrointenstinal tract. At the end of April 2008, it was temporarily withdrawn from the US Market because of problems related to crystallization of the drug, which caused unreliable drug
More informationClasses of Neurotransmitters. Neurotransmitters
1 Drugs Outline 2 Neurotransmitters Agonists and Antagonists Cocaine & other dopamine agonists Alcohol & its effects / Marijuana & its effects Synthetic & Designer Drugs: Ecstasy 1 Classes of Neurotransmitters
More informationFaculty of dentistry Second year CND Course CNS Drugs Dr. Ali Awadallah
Faculty of dentistry Second year CND Course CNS Drugs Dr. Ali Awadallah 0912320825 Drugs that act upon the central nervous system (CNS) influence the lives of everyone, everyday. Drugs that affect the
More informationPal Riba, M.D., Ph.D. Department of Pharmacology and Pharmacotherapy Semmelweis University, Budapest, Hungary November 7, 2017
Pal Riba, M.D., Ph.D. Department of Pharmacology and Pharmacotherapy Semmelweis University, Budapest, Hungary November 7, 2017 Definition of neurodegeneration Irreversible death of neurons resulting in
More informationVisualization and simulated animations of pathology and symptoms of Parkinson s disease
Visualization and simulated animations of pathology and symptoms of Parkinson s disease Prof. Yifan HAN Email: bctycan@ust.hk 1. Introduction 2. Biochemistry of Parkinson s disease 3. Course Design 4.
More informationA. General features of the basal ganglia, one of our 3 major motor control centers:
Reading: Waxman pp. 141-146 are not very helpful! Computer Resources: HyperBrain, Chapter 12 Dental Neuroanatomy Suzanne S. Stensaas, Ph.D. April 22, 2010 THE BASAL GANGLIA Objectives: 1. What are the
More informationFirst described by James Parkinson in his classic 1817 monograph, "An Essay on the Shaking Palsy"
Parkinson's Disease First described by James Parkinson in his classic 1817 monograph, "An Essay on the Shaking Palsy" Parkinson s disease (PD) is a neurological disorder characterized by a progressive
More informationParkinson s Disease. Sirilak yimcharoen
Parkinson s Disease Sirilak yimcharoen EPIDEMIOLOGY ~1% of people over 55 years Age range 35 85 years peak age of onset is in the early 60s ~5% of cases characterized by an earlier age of onset (typically
More informationMOVEMENT OUTLINE. The Control of Movement: Muscles! Motor Reflexes Brain Mechanisms of Movement Mirror Neurons Disorders of Movement
MOVEMENT 2 Dr. Steinmetz 3 OUTLINE The Control of Movement: Muscles! Motor Reflexes Brain Mechanisms of Movement Mirror Neurons Disorders of Movement Parkinson s Disease Huntington s Disease 1 4 TYPES
More informationNeurotransmitter Systems III Neurochemistry. Reading: BCP Chapter 6
Neurotransmitter Systems III Neurochemistry Reading: BCP Chapter 6 Neurotransmitter Systems Normal function of the human brain requires an orderly set of chemical reactions. Some of the most important
More informationTreatment of Parkinson s Disease: Present and Future
Treatment of Parkinson s Disease: Present and Future Karen Blindauer, MD Professor of Neurology Director of Movement Disorders Program Medical College of Wisconsin Neuropathology: Loss of Dopamine- Producing
More informationESSENTIAL PSYCHOPHARMACOLOGY, Neurobiology of Schizophrenia Carl Salzman MD Montreal
ESSENTIAL PSYCHOPHARMACOLOGY, 2011 Neurobiology of Schizophrenia Carl Salzman MD Montreal EVOLVING CONCEPTS OF SCHIZOPHRENIA Psychotic illness with delusions, hallucinations, thought disorder and deterioration;
More informationExam 2 PSYC Fall (2 points) Match a brain structure that is located closest to the following portions of the ventricular system
Exam 2 PSYC 2022 Fall 1998 (2 points) What 2 nuclei are collectively called the striatum? (2 points) Match a brain structure that is located closest to the following portions of the ventricular system
More informationA. General features of the basal ganglia, one of our 3 major motor control centers:
Reading: Waxman pp. 141-146 are not very helpful! Computer Resources: HyperBrain, Chapter 12 Dental Neuroanatomy Suzanne S. Stensaas, Ph.D. March 1, 2012 THE BASAL GANGLIA Objectives: 1. What are the main
More informationChapter 8. Parkinsonism. M.G.Rajanandh, Dept. of Pharmacy Practice, SRM College of Pharmacy, SRM University.
Chapter 8 Parkinsonism M.G.Rajanandh, Dept. of Pharmacy Practice, SRM College of Pharmacy, SRM University. Definition of Parkinson s Disease Parkinson's disease is a progressive, neurodegenerative disease
More informationIII./3.1. Movement disorders with akinetic rigid symptoms
III./3.1. Movement disorders with akinetic rigid symptoms III./3.1.1. Parkinson s disease Parkinson s disease (PD) is the second most common neurodegenerative disorder worldwide after Alzheimer s disease.
More informationThe Cerebral Cortex and Higher Intellectual Functions
The Cerebral Cortex and Higher Intellectual Functions Lobes in a lateral view of left hemisphere Atlas Fig.2-11 The Insula The Hidden Lobe Atlas Fig. 2-11 Atlas Fig. 2-39 Lobes in a lateral view of left
More informationParkinson s Disease Medications: Professionals Edition
Parkinson s Disease Clinic and Research Center University of California, San Francisco 505 Parnassus Ave., Rm. 795-M, Box 0114 San Francisco, CA 94143-0114 (415) 476-9276 http://pdcenter.neurology.ucsf.edu
More informationConnections of basal ganglia
Connections of basal ganglia Introduction The basal ganglia, or basal nuclei, are areas of subcortical grey matter that play a prominent role in modulating movement, as well as cognitive and emotional
More informationLecture 5 Skeletal muscle relaxants. Pharmacologic management of parkinsonism and other movement disorders.
Lecture 5 Skeletal muscle relaxants. Pharmacologic management of parkinsonism and other movement disorders. I. SKELETAL MUSCLE RELAXANTS Skeletal muscle relaxants are pharmacologically active substances
More informationPARKINSON S DISEASE. Nigrostriatal Dopaminergic Neurons 5/11/16 CARDINAL FEATURES OF PARKINSON S DISEASE. Parkinson s disease
5/11/16 PARKINSON S DISEASE Parkinson s disease Prevalence increases with age (starts 40s60s) Seen in all ethnic groups, M:F about 1.5:1 Second most common neurodegenerative disease Genetics role greater
More informationExtrapyramidal Motor System. Basal Ganglia or Striatum. Basal Ganglia or Striatum 3/3/2010
Extrapyramidal Motor System Basal Ganglia or Striatum Descending extrapyramidal paths receive input from other parts of motor system: From the cerebellum From the basal ganglia or corpus striatum Caudate
More informationBasal Ganglia. Steven McLoon Department of Neuroscience University of Minnesota
Basal Ganglia Steven McLoon Department of Neuroscience University of Minnesota 1 Course News Graduate School Discussion Wednesday, Nov 1, 11:00am MoosT 2-690 with Paul Mermelstein (invite your friends)
More informationParkinson s Disease Current Treatment Options
Parkinson s Disease Current Treatment Options Daniel Kassicieh, D.O., FAAN Sarasota Neurology, P.A. PD: A Chronic Neurodegenerative Ds. 1 Million in USA Epidemiology 50,000 New Cases per Year Majority
More informationOptimizing Clinical Communication in Parkinson s Disease:
Optimizing Clinical Communication in Parkinson s Disease:,Strategies for improving communication between you and your neurologist PFNCA Symposium March 25, 2017 Pritha Ghosh, MD Assistant Professor of
More information2-The age at onset of PD is variable, usually between 50 and 80 years, with a mean onset of 55 years (1).
Parkinson Disease 1-Parkinson disease (PD) is a chronic, progressive movement disorder resulting from loss of dopamine from the nigrostriatal tracts in the brain, and is characterized by rigidity, bradykinesia,
More informationMotor Fluctuations Stephen Grill, MD, PHD Parkinson s and Movement Disorders Center of Maryland and Johns Hopkins University
Motor Fluctuations Stephen Grill, MD, PHD Parkinson s and Movement Disorders Center of Maryland and Johns Hopkins University I have no financial interest with any entity producing marketing, re-selling,
More informationParkinson's Disease KP Update
Parkinson's Disease KP Update Andrew Imbus, PA-C Neurology, Movement Disorders Kaiser Permanente, Los Angeles Medical Center No disclosures "I often say now I don't have any choice whether or not I have
More informationChapter 4. Psychopharmacology. Copyright Allyn & Bacon 2004
Chapter 4 Psychopharmacology This multimedia product and its contents are protected under copyright law. The following are prohibited by law: any public performance or display, including transmission of
More informationTHIS MONTH Review: Parkinson s Disease
W-F Professional Associates, Inc. 400 Lake Cook Rd., Suite 207 Deerfield, IL 60015 847-945-8050 August 2009 Review of Parkinson s Disease #707-000-09-008-H01-P MISSING A LESSON? GO TO OUR WEBSITE, & DOWNLOAD
More informationPSY 302 Lecture 6: The Neurotransmitters (continued) September 12, 2017 Notes by: Desiree Acetylcholine (ACh) CoA + Acetate Acetyl-CoA (mitochondria) (food, vinegar) + Choline ChAT CoA + ACh (lipids, foods)
More informationClinical Features and Treatment of Parkinson s Disease
Clinical Features and Treatment of Parkinson s Disease Richard Camicioli, MD, FRCPC Cognitive and Movement Disorders Department of Medicine University of Alberta 1 Objectives To review the diagnosis and
More informationParkinson s Disease. Gillian Sare
Parkinson s Disease Gillian Sare Outline Reminder about PD Parkinson s disease in the inpatient Surgical patients with PD Patients who cannot swallow End of life care Parkinson s disease PD is the second
More informationDamage on one side.. (Notes) Just remember: Unilateral damage to basal ganglia causes contralateral symptoms.
Lecture 20 - Basal Ganglia Basal Ganglia (Nolte 5 th Ed pp 464) Damage to the basal ganglia produces involuntary movements. Although the basal ganglia do not influence LMN directly (to cause this involuntary
More informationThe motor regulator. 1) Basal ganglia/nucleus
The motor regulator 1) Basal ganglia/nucleus Neural structures involved in the control of movement Basal Ganglia - Components of the basal ganglia - Function of the basal ganglia - Connection and circuits
More informationParkinson's Disease and how you can make a difference with medication
Parkinson's Disease and how you can make a difference with medication Alyson Franks Parkinson's and Movement Disorder Nurse Specialist Royal Hallamshire Hospital No treatment all Complementary Therapy
More informationPrior Authorization with Quantity Limit Program Summary
Gocovri (amantadine) Prior Authorization with Quantity Limit Program Summary This prior authorization applies to Commercial, NetResults A series, SourceRx and Health Insurance Marketplace formularies.
More informationsymptoms of Parkinson s disease EXCEPT.
M. Angele Theard, M.D Asst. Professor, Washington University, St. Louis, MO Quiz team; Shobana Rajan, M.D; Suneeta Gollapudy, MD; Verghese Cherian, M.D, M. Angele Theard, MD This quiz is being published
More informationSynapses and Neurotransmitters
Synapses and Neurotransmitters Communication Between Neurons Synapse: A specialized site of contact, and transmission of information between a neuron and an effector cell Anterior Motor Neuron Figure 45-5
More informationThe Nervous System Mark Stanford, Ph.D.
The Nervous System Functional Neuroanatomy and How Neurons Communicate Mark Stanford, Ph.D. Santa Clara Valley Health & Hospital System Addiction Medicine and Therapy Services The Nervous System In response
More informationStudy Guide Unit 2 Psych 2022, Fall 2003
Study Guide Unit 2 Psych 2022, Fall 2003 Subcortical Anatomy 1. Be able to locate the following structures and be able to indicate whether they are located in the forebrain, diencephalon, midbrain, pons,
More informationThe Cerebral Cortex and Higher Intellectual Functions
The Cerebral Cortex and Higher Intellectual Functions The Cerebral cortex consists of 2 cerebral hemisphere and each hemisphere consists of 5 lobes (frontal, parietal,temporal,occipital,insular lobe which
More informationBrain Neurotransmitters
Brain Neurotransmitters Brain neurotransmitters Chemical substances released by electrical impulses into the synaptic cleft from synaptic vesicles of presynaptic membrane Diffuses to the postsynaptic membrane
More informationSynapses and Neurotransmitters.
Synapses and Neurotransmitters Loai.physiology@yahoo.com Communication Between Neurons Synapse: A specialized site of contact, and transmission of information between a neuron and an effector cell Anterior
More informationIdentification number: TÁMOP /1/A
Manifestation of Novel Social Challenges of the European Union in the Teaching Material of Medical Biotechnology Master s Programmes at the University of Pécs and at the University of Debrecen Identification
More informationNew Medicines Committee Briefing July 2011
New Medicines Committee Briefing July 2011 Pramipexole immediate-release (Mirapexin ) and Pramipexole modifiedrelease (Mirapexin prolonged release) for the treatment of Parkinson s Disease Pramipexole
More information8/28/2017. Behind the Scenes of Parkinson s Disease
BEHIND THE SCENCES IN Parkinson s Disease Behind the Scenes of Parkinson s Disease Anna Marie Wellins DNP, ANP C Objectives Describe prevalence of Parkinson's disease (PD) Describe the hallmark pathologic
More informationQualitative and Quantitative Composition
DATA SHEET KEMADRIN Tablets Procyclidine Hydrochloride 5 mg Tablets Qualitative and Quantitative Composition White, round, biconvex tablets, one face with a break line and coded KT above the break line
More informationXADAGO (safinamide) oral tablet
XADAGO (safinamide) oral tablet Coverage for services, procedures, medical devices and drugs are dependent upon benefit eligibility as outlined in the member's specific benefit plan. This Pharmacy Coverage
More informationDrug treatment of early Parkinson s disease (motor symptoms)
5 Drug treatment of early Parkinson s disease (motor symptoms) 5.1 When should treatment be started for a patient with Parkinson s disease? 67 5.2 Are there guidelines for the treatment of Parkinson s
More informationBasal Ganglia General Info
Basal Ganglia General Info Neural clusters in peripheral nervous system are ganglia. In the central nervous system, they are called nuclei. Should be called Basal Nuclei but usually called Basal Ganglia.
More informationASHI691: Why We Fall Apart: The Neuroscience and Neurophysiology of Aging. Dr. Olav E. Krigolson Lecture 5: PARKINSONS DISEASE
ASHI691: Why We Fall Apart: The Neuroscience and Neurophysiology of Aging Dr. Olav E. Krigolson krigolson@uvic.ca Lecture 5: PARKINSONS DISEASE The Basal Ganglia Primary motor cortex Execution of movement
More informationParkinson s Disease and Its Treatment
Parkinson s Disease and Its Treatment By H. David Bergman, Ph.D. Dean, Southwestern Oklahoma State University, College of Pharmacy Goals and Objectives Goals: To provide the pharmacist with information
More informationTRANSPARENCY COMMITTEE OPINION. 18 March 2009
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 18 March 2009 REQUIP LP 2 mg extended-release tablet Box of 21 tablets (CIP: 379 214-8) Box of 28 tablets (CIP: 379
More informationPSYCHIATRIC DRUGS. Mr. D.Raju, M.pharm, Lecturer
PSYCHIATRIC DRUGS Mr. D.Raju, M.pharm, Lecturer PSYCHIATRIC DRUGS Treat mood, cognition, and behavioral disturbances associated with psychological disorders Psychotropic in nature Most are not used recreationally
More informationFaculty. Joseph Friedman, MD
Faculty Claire Henchcliffe, MD, DPhil Associate Professor of Neurology Weill Cornell Medical College Associate Attending Neurologist New York-Presbyterian Hospital Director of the Parkinson s Institute
More informationSafinamide: un farmaco innovativo con un duplice meccanismo d azione
Safinamide: un farmaco innovativo con un duplice meccanismo d azione AINAT Sardegna Cagliari, 26 novembre 2016 Carlo Cattaneo Corporate Medical Advisor CNS & Rare Diseases Reichmann H. et al., European
More informationLecture XIII. Brain Diseases I - Parkinsonism! Brain Diseases I!
Lecture XIII. Brain Diseases I - Parkinsonism! Bio 3411! Wednesday!! Lecture XIII. Brain Diseases - I.! 1! Brain Diseases I! NEUROSCIENCE 5 th ed! Page!!Figure!!Feature! 408 18.9 A!!Substantia Nigra in
More informationParkinson s Disease. Graham A. Glass, MD. Assistant Professor of Neurology University of California San Francisco
Parkinson s Disease Graham A. Glass, MD Assistant Professor of Neurology University of California San Francisco San Francisco VA Medical Center Parkinson s Disease Research, Education and Clinical Center
More informationThe Nervous System. Chapter 4. Neuron 3/9/ Components of the Nervous System
Chapter 4 The Nervous System 1. Components of the Nervous System a. Nerve cells (neurons) Analyze and transmit information Over 100 billion neurons in system Four defined regions Cell body Dendrites Axon
More informationPrescribing issues in spasticity and dystonia. Professor Rajat Gupta Consultant Paediatric Neurologist Birmingham Children s Hospital
Prescribing issues in spasticity and dystonia Professor Rajat Gupta Consultant Paediatric Neurologist Birmingham Children s Hospital Cerebral palsy is common, affecting about 2-3 per 1000 children Surveillance
More informationAntidepressants and Sedatives. David G. Standaert, M.D., Ph.D. Massachusetts General Hospital Harvard Medical School
Antidepressants and Sedatives David G. Standaert, M.D., Ph.D. Massachusetts General Hospital Harvard Medical School Depression A frequent problem, affecting up to 5% of the population Common presentations
More informationEdyta Gołąbiewska PhD
Edyta Gołąbiewska PhD The depth of anesthesia has been divided into four sequential stages: Stage 1: Analgesia (induction) Stage 2: Excitement Stage 3: Surgical anesthesia Stage 4: Medullary paralysis
More informationParkinson s Disease Update. Colleen Peach, RN, MSN, FNP Movement Disorders Clinic Emory University School of Medicine March 7, 2015
Parkinson s Disease Update Colleen Peach, RN, MSN, FNP Movement Disorders Clinic Emory University School of Medicine March 7, 2015 Parkinson s Disease Progressive, chronic, neurodegenerative disease Slow,
More informationThe antipsychotic drugs (also called neuroleptics or major tranquilizers) are used primarily to treat schizophrenia, but they are also effective in
Antipsychotic Drugs The antipsychotic drugs (also called neuroleptics or major tranquilizers) are used primarily to treat schizophrenia, but they are also effective in other psychotic and manic states.
More informationChapter 12 Nervous Tissue
9/12/11 Chapter 12 Nervous Tissue Overview of the nervous system Cells of the nervous system Electrophysiology of neurons Synapses Neural integration Subdivisions of the Nervous System 1 Subdivisions of
More informationDrugs Targeting the CNS
Drugs Targeting the CNS Hypnotics/Anxiolytics Antidepressants Neuroleptics Parkinson Epilepsy Drugs Targeting the CNS Neurotransmitters in the CNS Norepinephrine: Excitory or inhibitory Targeted by: MAO
More informationHYPERBARIC OXYGEN TREATMENT ON A PARKINSON S DISEASE PATIENT: A CASE STUDY Hoggard ML, Johnson KE and Shirachi DY. Chico Hyperbaric Center, Chico, CA
HYPERBARIC OXYGEN TREATMENT ON A PARKINSON S DISEASE PATIENT: A CASE STUDY Hoggard ML, Johnson KE and Shirachi DY. Chico Hyperbaric Center, Chico, CA 95926 and Department of Physiology and Pharmacology,
More informationSedative H ypnotic D rugs
Sedative H ypnotic D rugs H M Bakhriansyah, dr., M.Kes., M.Med.Ed Department of Pharmacology Medical Faculty Lambung Mangkurat University Terminology Sedative state Hypnotic state Sleeping NREM 4 phases
More informationlevodopa-induced dyskinesia
Journal of Neurology, Neurosurgery, and Psychiatry, 1978, 41, 702-706 Sodium valproate in the treatment of levodopa-induced dyskinesia P. A. PRICE, J. D. PARKES, AND C. D. MARSDEN From the University Department
More informationNeurotransmitters acting on G-protein coupled receptors
Neurotransmitters acting on G-protein coupled receptors Part 1: Dopamine and Norepinephrine BIOGENIC AMINES Monoamines Diamine Overview of Neurotransmitters and Their Receptors Criteria for defining a
More information