FOR A LISTING OF AVAILABLE PUBLICATIONS USING THE TRACTS COHORT PLEASE SEE :

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Translational Research Center for TBI and Stress Disorders TRACTS VA Boston Healthcare System 2009-2019: A VA Rehab R & D Center of Excellence Devoted to the Development of Innovative Methods to

1 Translational Research Center for TBI and Stress Disorders TRACTS VA Boston Healthcare System : A VA Rehab R & D Center of Excellence Devoted to the Development of Innovative Methods to Diagnose and Treat OEF/OIF/OND Veterans with Co-Morbid Deployment Related Trauma THE FOLLOWING PAGES CONTAIN A SNAPSHOT OF THE CHARACTERISTICS OF THE TRACTS LONGITUDINAL STUDY AND CORE B DATASET AS OF FEBRUARY NOTE THAT SOME STATISTICS HAVE NOT BEEN UPDATED TO REPRESENT THE COMPLETE CURRENT SAMPLE. FOR A LISTING OF AVAILABLE PUBLICATIONS USING THE TRACTS COHORT PLEASE SEE :

2 Medical/ Biological Blood Chemistry GWAS TRACTS Assessment Core Neuropsych Domains Simple/Divided Attention Information Processing Speed Affective/ Psychosocial PTSD: CAPS & PCL-C DSM-IV AXIS I: SCID Blast/TBI Boston Assessment of TBI-Lifetime Ohio State University TBI ID Neuroanatomy S/F MRI Cortical Volume Cortical Thickness Neuro-steroid Executive Function Traumatic Life Events Questionnaire Neurobehavioral Symptom Inventory Diffusion Tensor Declarative/ Procedural Memory Deployment Risk & Resiliency Inventory Resting-State Networks Pre-morbid Function Depression, Anxiety & Stress Scale-21 Functional Connectivity Perception Pittsburg Sleep Quality Index Task-Based fmri Symptom Validity Psychomotor Speed McGill Pain Questionnaire Alcohol, Nicotine Sickness Impact Profile The TRACTS Data Repository contains over 2000 variables and may be accessible for research by qualified and credentialed investigators. For further information please contact:

Medical/Biological TRACTS Assessment Core Neuropsych Domains Affective/

Attention As PTSD: of 2/16: CAPS Max=432 & PCL-C Boston Assessment of

SCID Ohio State University TBI ID Cortical Thickness Neuro-steroid Traumatic

Inventory Questionnaire Declarative/ Deployment Risk & Procedural Memory

Depression, Anxiety Pre-morbid Function & Stress Scale-21 Perception Pittsburg

Symptom Validity Projected Time 2 Enrollment=500 Questionnaire Diffusion Tensor

3 Medical/Biological TRACTS Assessment Core Neuropsych Domains Affective/ Psychosocial Blast/TBI Neuroanatomy S/F MRI Blood Chemistry Simple/Divided Attention As PTSD: of 2/16: CAPS Max=432 & PCL-C Boston Assessment of TBI-Lifetime Cortical Volume GWAS Information Processing Speed DSM-IV AXIS I: SCID Ohio State University TBI ID Cortical Thickness Neuro-steroid Traumatic Life Executive Function Certified Data Neurobehavioral Events Time 1=450 Symptom Inventory Questionnaire Declarative/ Deployment Risk & Procedural Memory Currently Resiliency Tested Inventory Time 1 =485 Currently Tested Time 2= 250 Depression, Anxiety Pre-morbid Function & Stress Scale-21 Perception Pittsburg Sleep Quality Index Projected Time 1 Enrollment ( )=750 McGill Pain Symptom Validity Projected Time 2 Enrollment=500 Questionnaire Diffusion Tensor Resting-State Networks Functional Connectivity Task-Based fmri Psychomotor Speed Alcohol, Nicotine Sickness Impact Profile

4 Characterization of the TRACTS Cohort (n=255) Demographics & Service Information Demographics TRACTS VHA Veterans (n=771,874) Males 227 (89%) 88% Education 13.9 ± 1.9 Race White 178 (70%) 80.8% Black 25 (10%) 11.7% Hispanic 40 (16%) 6.3% Other 7 (2%) 5.15% Unknown/Missing 5 (2%) Birth Cohort

5 Characterization of the TRACTS Cohort (n=255) Demographics & Service Information Service Branch TRACTS VHA Veterans (n=771,874) National Guard/Reserve 51.9% 44.2% Navy 3.9% 13.2% Marines 18% 13.6% Air Force 11.3% 12.5% Army 66.4% 60.5% OEF/OIF/OND Deployments Number 1.4 ± 0.7 Duration (months) 14.3 ± 8.5 Combat Exposure 15.8 ± 11.8

7 BAT-L Assessment TBI is assessed during three time epochs: Pre-military Military Post-military Evaluate three most severe injuries in each epoch Open-ended interview-style questioning; Forensic Approach Document the occurrence and duration of neurobehavioral symptoms (LOC, PTA, AMS) following each injury recorded.

8 Blast Exposures TRACTS Cohort (n=255) < 10 meters meters meters Total Blast Exposures <100 meters Number of Service Members Exposed 100 (39%) 102 (40%) 181 (71%) 200 (78%) Mean Blasts per Service Member 2.80 (26.15%) 2.83 (14.26%) 20 (80.70%) (97.74%) Median Blasts per Service Member Range of Blasts per Service Member

9 TBI s over the Lifetime for the TRACTS Cohort (n=255)

10 Demographics Total Military TBI No Military TBI n (n=410) (n=196) (n=214) P- value Age, mean (SD) (8.46) (8.04) (8.85) Males, No. (%) (91.0%) 184 (93.9%) 189 (88.3%) EducaKon, mean (SD) (1.88) (1.81) (1.93) Unit Type, No. (%) Ac2ve Duty 205 (50%) 116 (59.2%) 89 (41.6%) Reserve/Guard 205 (50%) 80 (40.8%) 125 (58.4%) Service Branch, No. (%) Army 255 (64.7%) 120 (62.5%) 135 (66.8%) Navy 12 (3.1%) 8 (4.2%) 4 (2.0%) Marines 101 (25.6%) 58 (30.2%) 43 (21.3%) Air Force 25 (6.4%) 6 (3.1%) 19 (9.4%) Coast Guard 1 (0.3%) 0 (0%) 1 (0.5%) OEF/OIF/OND Deployments Number, mean (SD) ± ± ± Dura2on (months), mean (SD) ± ± ± Combat Exposure, mean (SD) ± ± ± <0.0001

11 Total Military TBI No Military TBI Psychiatric & Behavioral CondiKons n (n=410) (n=196) (n=214) P- value PTSD, No. (%) (63.9%) 157 (80.1%) 105 (49.1%) < Depressive Disorders, No. (%) (27.6%) 69 (35.2%) 44 (20.6%) Major Depressive Disorder, No. (%) (24.9%) 63 (32.1%) 39 (18.2%) Other Depressive Disorder, No. (%) (2.9%) 7 (3.6%) 5 (2.3%) Anxiety Disorder, No. (%) (21.2%) 44 (22.5%) 43 (20.1%) Panic Disorder, No. (%) (8.6%) 24 (12.2%) 11 (5.2%) Social Phobia, No. (%) (6.4%) 11 (5.6%) 15 (7.0%) Generalized Anxiety Disorder, No. (%) (8.1%) 16 (8.2%) 17 (8.0%) Other Anxiety Disorder, No. (%) (5.1%) 11 (5.6%) 10 (4.7%) Substance Use Disorders, No. (%) (15.9%) 37 (18.9%) 28 (13.1%) Alcohol Abuse/Dependence, No. (%) (13.5%) 31 (15.8%) 24 (11.3%) Other Abuse/Dependence, No. (%) (3.9%) 8 (4.1%) 8 (3.7%) Pain, No. (%) (70.7%) 145 (83.3%) 118 (59.6%) Sleep Disturbance, No. (%) (79.4%) 160 (88.4%) 149 (71.6%) < Number of Psychiatric & Behavioral ± ± ± 1.48 < CondiKons, mean (SD) 3+ Comorbidi2es (57.8%) 128 (75.3%) 84 (42.6%) <0.0001

PTSD and Other Invisible Wounds affecting our Service Members and Veterans. Alan Peterson, PhD, ABPP

PTSD and Other Invisible Wounds affecting our Service Members and Veterans Alan Peterson, PhD, ABPP 1 Alan Peterson, PhD, ABPP Retired USAF Lt Col Clinical Health Psychologist Former Chair, Department