Histocompatibility. HLA Serologic Typing (Class I/II) ABO, HLAS, HLAS Surveys & Anatomic Pathology Education Programs
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1 Histocompatibility Analytes/procedures in bold type are regulated for proficiency testing by the Centers for Medicare & Medicaid Services (CMS). HLA Serologic Typing (Class I/II) ABO, HLAS, HLAS1 Procedure ABO HLAS HLAS1 Challenges per Shipment ABO grouping (includes A subtyping) 5 HLA serologic typing (Class I and Class II) 3 HLA serologic typing (Class I only) 3 Surveys HLAS and HLAS1 are designed for laboratories performing HLA typing by serologic methods. Laboratories ordering Survey HLAS will be able to report both Class I and Class II serologic results. Those laboratories that report only Class I types should order Survey HLAS1. Survey ABO may be ordered only in conjunction with either Survey HLAS or HLAS1. Each shipment of Survey ABO will include five 2.0-mL specimens of 3% red blood cell suspension and five 3.0-mL corresponding serum specimens. Each Survey HLAS shipment and each Survey HLAS1 shipment will contain three suspensions of purified peripheral blood lymphocytes. Product Fulfillment Group HL 2008 Surveys & Anatomic Pathology Education Programs Histocompatibility 167
2 Option 1 for Customer Contact Center Antibody Titer ABT, ABT1, ABT2 Analyte/Procedure ABT ABT1 ABT2 Challenges per Shipment Anti-A Titer 1 Anti-D Titer 1 Survey ABT is designed for laboratories performing red cell antibody titers as a part of any of the following workups: a prenatal antibody quantification workup; the management of recipients of ABO incompatible bone marrow transplants; determination of eligibility of O or B kidney transplant recipient candidates for receiving an A 2 kidney; and/or assessment of the need and monitor the effect of plasma exchange in transplant recipients who are ABO incompatible with their donors. Survey ABT1 is designed for laboratories performing titers for Anti-A. Survey ABT2 is designed for laboratories performing titers for Anti-D. Laboratories ordering Surveys ABT, ABT1, or ABT2 will be able to report using a variety of techniques. Each shipment of Survey ABT will include one plasma specimen for anti-d titer, with one corresponding titer cell (3% red blood cell suspension) and one plasma specimen for anti-a titer with one corresponding titer cell (3% red blood cell suspension). Each shipment of Survey ABT1 will include one plasma specimen for anti-a titer with one corresponding titer cell (3% red blood cell suspension). Each shipment of Survey ABT2 will include one plasma specimen for anti-d titer, with one corresponding titer cell (3% red blood cell suspension). 168 Histocompatibility College of American Pathologists
3 HLA Molecular Typing ML, DL, DML Procedure ML DL DML Challenges per Shipment Molecular HLA-A, B, and C typing (Class I) 5 Molecular HLA-DR, DQ, and DP typing (Class II) 5 Surveys ML and DL are designed for laboratories performing HLA typing by molecular methods, such as clinical transplant laboratories and laboratories performing HLA disease-association tests. Note: Serological equivalents may also be reported. Survey DML provides a convenient and cost-effective ordering option for laboratories conducting both Class I and Class II molecular typing. Each shipment will include five whole blood specimens in CPD or CPD-A. HLA-B27 Typing B27 Procedure B27 Challenges per Shipment HLA-B27 typing 5 Survey B27 is designed for laboratories performing HLA-B27 typing by a variety of methods. Each shipment will include five whole blood specimens Surveys & Anatomic Pathology Education Programs Histocompatibility 169
4 Option 1 # for Customer Contact Center HLA Crossmatching, Antibody Screen, and Antibody Identification (Class I) MX1B, MX1C, MX1E Procedure MX1B MX1C MX1E Challenges per Shipment Crossmatching 8 Antibody screen 4 Antibody identification 4 These Surveys are designed for laboratories performing HLA Class I crossmatching and/or antibody screening and specificity identification. Specimen volumes in each of the Surveys vary, and participants should enroll in the Survey that contains the volume that meets their testing requirements. For example, laboratories that perform testing only by serologic methods may want to order Survey MX1B. Laboratories that perform testing by flow cytometry, ELISA, or multiple methods may require larger volumes and may need to order Survey MX1C. Laboratories that require additional plasma for antibody screening/antibody specificity identification may want to subscribe to Survey MX1E. Note: Survey MX1E provides extra plasma only and must be ordered in conjunction with Survey MX1B or MX1C. Laboratories will be able to report results of multiple testing methods. Each shipment of Survey MX1B will contain four 0.25-mL plasma specimens and two purified peripheral blood lymphocyte specimens. Each Survey MX1C shipment will contain four 0.50-mL plasma specimens and two purified peripheral blood lymphocyte specimens. Each Survey MX1E shipment will contain four 0.3-mL plasma specimens. Product Fulfillment Group MX1 For laboratories conducting BOTH Class I and Class II HLA crossmatching, antibody screening, and antibody identification testing, refer to page 172 for Surveys MXB and MXC. 170 Histocompatibility College of American Pathologists
5 HLA Crossmatching, Antibody Screen, and Antibody Identification (Class II) MX2B, MX2C, MX2E Procedure MX2B MX2C MX2E Challenges per Shipment Crossmatching 4 Antibody screen 2 Antibody identification 2 Surveys MX2B, MX2C, and MX2E are designed for laboratories performing HLA Class II crossmatching and/or antibody screening and specificity identification. Specimen volumes in each of the Surveys vary, and participants should enroll in the Survey that contains the volume that meets their testing requirements. For example, laboratories that perform testing only by serologic methods may want to order Survey MX2B. Laboratories that perform testing by flow cytometry, ELISA, or multiple methods may require larger volumes and may need to order Survey MX2C. Laboratories that require additional plasma for antibody screening/antibody specificity identification may want to subscribe to Survey MX2E. Note: Survey MX2E provides extra plasma only and must be ordered in conjunction with Survey MX2B or MX2C. Laboratories will be able to report results of multiple testing methods. Each shipment of Survey MX2B will contain two 0.25-mL plasma specimens and two purified peripheral blood lymphocyte specimens. Each Survey MX2C shipment will contain two 0.5-mL plasma specimens and two purified peripheral blood lymphocyte specimens. Each Survey MX2E shipment will contain two 0.3-mL plasma specimens. Product Fulfillment Group MX2 For laboratories conducting BOTH Class I and Class II HLA crossmatching, antibody screening, and antibody identification testing, refer to page 172 for Surveys MXB and MXC Surveys & Anatomic Pathology Education Programs Histocompatibility 171
6 Option 1 for Customer Contact Center HLA Crossmatching, Antibody Screen, and Antibody Identification Class I and Class II Combinations MXB, MXC Procedure Survey Code MXB MXC Crossmatching, antibody screen*, and antibody identification, Class I MX1B Crossmatching, antibody screen*, and antibody identification, Class II MX2B Crossmatching, antibody screen*, and antibody identification, Class I MX1C Crossmatching, antibody screen*, and antibody identification, Class II MX2C *The analyte/challenge antibody screen is ungraded/educational in this Survey. Combination Surveys MXB and MXC allow your laboratory to receive Surveys MX1B/MX2B or MX1C/MX2C in one orderable product. Surveys MX1E (Class I) and MX2E (Class II) provide extra plasma only and can be ordered with combination Surveys MXB and MXC. Refer to pages 170 and 171 for more information on the specific Crossmatching, Antibody Screen, and Antibody Identification Surveys. Specimen Information Refer to the specific Surveys on pages 170 and 171 for specimen and analyte information. Monitoring Engraftment ME Procedure ME Challenges per Shipment Stem cell monitoring engraftment 3 Survey ME is designed for laboratories supporting stem cell transplant programs and laboratories monitoring chimerism after organ transplantation. This Survey will test the laboratory s ability to effectively monitor allogeneic donor cell engraftment or chimerism. Each shipment will include two whole blood specimens labeled A and B and three specimen mixtures of A and B. 172 Histocompatibility College of American Pathologists
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