Clinical Education Initiative PRE-EXPOSURE PROPHYLAXIS. Speaker: Antonia Urbina, MD
|
|
- Scott Bryant
- 5 years ago
- Views:
Transcription
1 Clinical Education Initiative PRE-EXPOSURE PROPHYLAXIS Speaker: Antonia Urbina, MD 9/6/2017
2 Pre-Exposure Prophylaxis [video transcript] 1 00:00:07,480 --> 00:00:09,139 I mean we're like really scaling up PrEP down here at Mt. Sinai across all of our sites. So it's definitely an important intervention. 00:00:18 So I'm going to speak on that. 00:00:22 So these are my disclosures. 00:00:26 And these are the objectives so I am going to weave in the New York state and CDC guidelines for PrEP, describe candidacy selection of candidates for PrEP, and the management of the patients on PrEP. 00:00:40 So this was a very interesting site. So this is from the CDC the national HIV surveillance system data. And it looked at trends in HIV infection among men who have sex with men from 2008 to So the good news is that we've seen a slight decrease in new HIV diagnoses among men who have sex with men from the years 2008 to However we've seen significant increases in Hispanic Latinos with new infections in seven states and in African-American men in eight states and in those between the ages of 13 and 24 and 25 to 34 in 16 to 18 states. We've seen significant decreases However in whites in 14 states and in older MSM and 23 and seven states, respectively. So really trends at the national level obscure these important kind of my group geographic variations in HIV incidence. But I just wanted to circle in New York so New York's doing great in terms of really significant decreases in all MSM in black and white. So you'll see that green means decrease in incidence but where we're seeing increases in all MSM is in the south. Right. Look Alabama, Arkansas, Arizona is in the southwest but Louisiana, South Carolina, and Texas. So again, these are the regional variances in HIV incidence. But again, overall the trend is down however increases in Hispanic Black and those younger aged MSM. 00:02:33 All right. So the opposites attract study looked at HIV transmission in MSM serodiscordant or magnetic couples, one's positive the other negatives, in Australia, Thailand and Brazil. So this was 591 couple years of follow up in about 360 couples. Over 80 percent were on antiretrovirals. About 80 percent had an undetectable viral load. Close to 60 percent reported anal sex with outside partners. And there was about a 12 percent incidents of our actual prevalence of STI's. And what they found is with all these couple years of follow-up, and over 7000 acts of condom less anal sex, that there was no linked transmissions. So zero. And if you basically look at any so for any inserted condom less receptive. And then they also interesting look at dividing up viral loads those that were rarer than 200 even less than 1
3 200 and no linked transmission in this MSM cohort so this kind of supports the view that a person who has consistently undetectable HIV RNA levels, and is adherent to their medications has really a really negligible chance of transmitting to their sexual partner. So this adds to the increasing data showing that undetectable really does equal un-infectious 00:04:06 OK. So they also presented more data on the PROUD study. This is a long term follow up of PrEP use in a real world setting. So this study was actually first presented at Kroy last year, it's a multi-center study in the UK, 13 sexual health clinics and it was basically an open label study looking at HIV negative men who have sex with men who engage in condomless, anal intercourse they could have a history of hepatitis B. Co-infection and what they did in this study is that they had they had a first phase and in it phase. Is that my echo? [Rob Walsh] Someone needs to mute their line. Ok thanks. 00:04:58 [Dr. Urbina] Yeah. So this study to the quarter of patients so randomize them to either immediately start on on Truvada or to defer for 12 months. And the DSMB monitoring board basically had to interrupt the study because the immediate arm showed an 86 percent reduction in HIV acquisition. So now what they did is that those in that deferred arm were then allowed to start on Truvada because it showed efficacy and now at the resent IAS conference they show their data for this extension arm. 00:05:35 So what they found, and look at the deferred phase, there were four HIV infections in those that got Truvada immediately versus 21 in the deferred. So in this post-deferred where everybody got Truvada, you'll see that it was five and one new infection. So again really supporting that even three years after initiation. Just two years after initiation that PrEP was still efficacious. Now what we see here is that the rates of STI's in this extension phase remained high. So 30 percent rates of rectal gonorrhea about 30 percent rates of rectal chlamydia. We do see that the rates of syphilis did tick up in the extension phase. So we saw a sustained reduction in HIV with PrEP. And we saw high rates of STI which really reflects the ongoing risk and need for patients on PrEP 00:06:38 OK. And then they also provided an update for the IPERGAY substudy. And this is on demand PrEP amongst high risk MSM and they really wanted to look at infrequent sexual intercourse amongst their cohorts to see if this On-Demand PrEP was still efficacious. So just to review, this was a double blind open label study both in France and Canada. Participants had to be HIV negative with their test at least within one month. High risk MSM, and they define it as having at least two partners within six months. Also condom-less sex, normal kidney function, normal liver function. No coexisting HPV or HCV. So basically the strategy for this one was that patients either receive active drug or placebo and it's two tablets of Truvada two to 24 hours before sexual exposure than one tablet 24 hours after. And then one 48 hour hours after so four around the time of the exposure. But what happened is that the majority of these participants had so much exposure that they were averaging about four tablets week which is kind 2
4 of the dosing that you need to to obtain protective levels. So what they did is that they look at a set cohort of these patients who took less than 15 tablets per month so have less frequent exposures and they wanted to provide outcomes of that. 00:08:17 And what they show here. So there was approximately 269 participants that reported less than 15 PrEP pills per month. Their medium number of pills per month were 9.5 medium number of sexual intercourse per month was five. And what they found is no new HIV infections amongst the PrEP arm that had fewer than 15 pills on PrEP and there were six new infections in the placebo arm. So that's an efficacy of 100 percent in patients that adhere to this On-Demand PrEP with less frequent encounters. So you know it really supports a little bit more of this view that this On-Demand PrEP may be effective in MSM with less frequent sexual encounters. However, both the CDC and the New York state still do not recommend On-Demand dosing for PrEP. But, I think this is a conversation that I would have for my patients that say hey I want to minimize exposure to Truvada. Our is there any data that may support shorter courses of PrEP. 00:09:24 So I think this was very compelling as well. All right so they also had a substudy On-Demand amongst high-risk MSM who participate in Chemsex and they defined Chemsex on the bottom left here is "use of psychoactive substances during sex". So basically drugs like gamma hydroxybutyrate, methamphetamine, methedrone is another one that they use and this was in a substudy in this. They also included injection drug use especially methamphetamine. So this was a substudy of the Open Label section period. They saw no difference in social demographic characteristics between chemsexers and non-chemsexers. Chemsexers had more vulnerable psychological profiles, more anxiolytic consumption, and higher sensation seeking scores. The chemsex practice was associated with more PrEP use which was good, more casual multiple partners and more high risk, hard core practices like fisting. And PrEP what they found is a suitable tool to reduce HIV transmission in chemsexers. It really provides us an opportunity to provide prevention interventions, especially PrEP, to participants that do engage in chemsex. So this is the highest of the highest risk. What we do know is that there's no direct drug drug interactions and Truvada. So just looking at the right chemsex and PrEP use, so some of the differences between those that reported chemsex versus no chemsex. So again, there was higher anxiolytic consumption, probably with their methamphetamine crash. There was higher sensation seeking scores and those that there was higher injection drug use with chemsex versus non-chemsex. There was more sexual encounters and those sexual encounters tended to be less with their main partners more with casual partners and more with multiple partners. But again higher PrEP use which I think is important so that in this cohort of patients you know definitely PrEP can still be a viable actual strategy for HIV prevention. 00:11:48 All right. So this is looking at the national electronic prescription database for new PrEP starts in the U.S. I think more recent data shows about 130,000 U.S. persons are on PrEP. So you'll see that, since its 3
5 inception, the growth has been somewhat exponential with about seven times increase since the third quarter of The majority of starts have been male, 85 percent, with female, 15 percent. 00:12:20 Now this is where I think it's disappointing. Let's look at PrEP utilization in the U.S. on the left PrEP use 2016 basically kind of reflects the U.S. demographics but so 73 percent of PrEP utilizers are white, 10 percent are black, 13 percent are Hispanic, and 4 percent are Asian. Look at the graph on the right. Latest data from CDC looking at new HIV infections by race 44 percent black, 24 percent Hispanic, 26 percent white, and 2 percent Asian. I think that graph is very illustrative. That we're not really meeting our target populations, at all. And why are we not? 00:13:19 So this was a study that was done by Ken Mayer out of Fenway and he did a survey study. So he sent out a survey for MSM from the U.S. He posted these two surveys on two very popular sexual networking sites and what he found is that condomless anal sex occurred at least twice in the past that occurred past in the three months at least 75 percent of the respondents acknowledged condomless sex at least twice in the past three months. The majority of them had not used PrEP and 22 percent were unaware of PrEP the major barriers to PrEP uptake. And let's look at the right first so the reasons for not using PrEP amongst these informed non-users. So these were ones that knew about PrEP but were not on PrEP close to So their major concerns were costs, 40 percent. Potential side effects, 31 percent. Potential effects on insurance, 20 percent. Their medical providers reaction if I asked for it, so concerns about that, 18 percent, 30 percent do not know where to access PrEP so again, access issue. And another 19 percent do not feel that they were at risk. So if we break it down a little bit the major barriers to PrEP uptake were divided up into structural factors. So cost, access, insurance, anticipated side effects, and low perceived risk were the major categories while the vast majority of this cohort was not on PrEP. So the most common PrEp uptake barriers by subgroups, so older MSM were more concerned about the anticipated side effects, potentially. And then for access concerns they were much more common amongst black MSM, less educated MSM, and MSM born outside the US undocumented, which kind of makes sense. And it results really underscores the need to educate at risk MSM and address these access concerns about disproportionately affected groups. But again a huge disparity where we need PrEP to be really scaled up we're not really penetrating into those sectors. 00:15:58 All right. And then the last slide here is HPTN 077 so this is the future for not just prevention but also treatment. So this is probably the first one that's going to come to market is the long acting injectable cabotegravir. So the study is looking at the drug concentrations in low risk HIV uninfected women and men and they have two dosing arms that they were looking at so 600 milligrams every two months or 800 milligrams every three months. So this is an ongoing randomized three to one phase 2a doubleblind placebo controlled trial in Brazil, South Africa, Malawi, and the U.S. And they're looking at intramuscular cabotegravir, 600 every two months, 800 hundred every three months. This is the break out for the demographics so the median age 30, 34 percent male, 27 percent white, 41 percent black, 24 percent Hispanic. So great spread on the demographics and on gender. Both cabotegravir doses were 4
6 well tolerated. What you want is for the trough, so when those lines go down, you want for the troughs to be above that four times the IC 50. So it looks like the 600 milligrams a week arm had better pharmacokinetics. But both were well-tolerated. They just reported some mild injection site reactions but they're going to be moving forward with this 600 milligram q8 weeks after a four week loading dose with the oral cabotegravir and it looks like that's gonna meet the pharmacokinetic targets. And now they're in phase 3 studies so this will be coming soon as effective kind of new formulation for PrEP. 00:18:00 And there special thanks to Ian Frank, Chris Ferraris, Simply Speaking. [end] 5
HIV PrEP in Ireland. Information booklet for people who are accessing PrEP themselves or are considering accessing PrEP
HIV PrEP in Ireland Information booklet for people who are accessing PrEP themselves or are considering accessing PrEP The HSE Sexual Health and Crisis Pregnancy Programme (SHCPP) and the HIV PrEP working
More informationDrug development in relation to PrEP and the PROUD study
Drug development in relation to PrEP and the PROUD study David Dolling Medical Statistician MRC Clinical Trials Unit 18 th October 2012 What is PrEP? - Pre-exposure Prophylaxis A strategy that uses antiretrovirals
More informationCase Studies in PrEP Management. Kevin L. Ard, MD, MPH Massachusetts General Hospital, National LGBT Health Education Center April 15, 2016
Case Studies in PrEP Management Kevin L. Ard, MD, MPH Massachusetts General Hospital, National LGBT Health Education Center April 15, 2016 Continuing Medical Education Disclosure Program Faculty: Kevin
More informationThe role of Integrase Inhibitors during HIV prevention
The role of Integrase Inhibitors during HIV prevention Pep Coll AIDS Research Institute-IrsiCaixa Fight AIDS Foundation BCN Checkpoint 2nd Global HIV Clinical Forum: Integrase Inhibitors Paris July 22th
More informationHIV Pre-Exposure Prophylaxis (HIV PrEP) in Scotland. An update for registered practitioners September 2017
HIV Pre-Exposure Prophylaxis (HIV PrEP) in Scotland An update for registered practitioners September 2017 Key Messages HIV is a major public health challenge for Scotland with an annual average of 359
More informationPrEP for HIV Prevention. Adult Clinical Guideline from the New York State Department of Health AIDS Institute
PrEP for HIV Prevention Adult Clinical Guideline from the New York State Department of Health AIDS Institute www.hivguidelines.org Purpose of the PrEP Guideline Raise awareness of PrEP among healthcare
More informationPrEP in Scotland. PrEP. in Scotland. PrEP. PrEP. PrEP. PrEP is a combination pill that prevents HIV.
PrEP in Scotland PrEP PrEP PrEP PrEP is a combination pill that prevents HIV. 1 Contents Introduction 3 What is PrEP 3 Who should take PrEP 4 Getting PrEP in Scotland 5 Side effects and interactions with
More informationHIV PREVENTION WITH PRE-EXPOSURE PROPHYLAXIS: A PRIMER FOR PHARMACISTS. Speaker: Susan MK Lee, PharmD, BCPS, CDE
Clinical Education Initiative Support@ceitraining.org HIV PREVENTION WITH PRE-EXPOSURE PROPHYLAXIS: A PRIMER FOR PHARMACISTS Speaker: Susan MK Lee, PharmD, BCPS, CDE 12/13/2016 HIV Prevention with Pre-Exposure
More informationPre-Exposure Prophylaxis (PrEP) for HIV Infection
Pre-Exposure Prophylaxis (PrEP) for HIV Infection Jeffrey D. Klausner, MD, MPH Professor of Medicine and Public Health University of California Los Angeles Attending Physician UCLA Center AIDS Research
More informationQUESTIONS AND ANSWERS ABOUT PARTNERS PrEP AND VOICE
CONTACT: Lisa Rossi +1-412-641-8940 +1-412- 916-3315 (mobile) rossil@upmc.edu QUESTIONS AND ANSWERS ABOUT PARTNERS PrEP AND VOICE 1. What is the Partners PrEP study? The Partners PrEP Study is a double-blind,
More informationPrEP for HIV prevention. Pep Coll AIDS Research Institute-IrsiCaixa Fight AIDS Foundation BCN Checkpoint
PrEP for HIV prevention Pep Coll AIDS Research Institute-IrsiCaixa Fight AIDS Foundation BCN Checkpoint DISCLOSURES I have received a research grant from Gilead Sciences awarded to my institution I have
More informationPRE-EXPOSURE PROPHYLAXIS (COMBINED JUNE 2015)
Clinical Education Initiative Support@ceitraining.org PRE-EXPOSURE PROPHYLAXIS (COMBINED JUNE 2015) Antonia Urbina, MD Jeffrey Kwong, NP, MPH Mathew Rodriguez 6/18/2015 Pre-Exposure Prophylaxis (Combined
More informationDisclosure. Learning Objectives. Epidemiology. Transmission. Risk of Transmission PRE-EXPOSURE PROPHYLAXIS (PREP) FOR HIV PREVENTION 50,000.
Disclosure PRE-EXPOSURE PROPHYLAXIS (PREP) FOR HIV PREVENTION I have no financial interest in and/or affiliation with any external organizations in relation to this CE program. DaleMarie Vaughan, PharmD
More informationIncidence des IST chez les PrEPeurs
Incidence des IST chez les PrEPeurs Jean-Michel Molina Hopital Saint-Louis, Université de Paris Diderot, Inserm U941, Paris, France PrEP, IST et Santé Sexuelle, 29 Mars 2018, Paris La PrEP en France Début
More informationI M ENDING HIV PATIENT INFORMATION. endinghiv.org.au/prep
I M ENDING HIV PrEP PATIENT INFORMATION endinghiv.org.au/prep THIS BOOKLET PROVIDES YOU WITH INFORMATION ABOUT Pre-Exposure Prophylaxis (PrEP) for HIV. CONTENTS 06 Who will benefit from PrEP? 04 What is
More informationMoving beyond condoms to prevent HIV transmission. Are you Prepared for HIV PrEP?
Moving beyond condoms to prevent HIV transmission Are you Prepared for HIV PrEP? The Issues New HIV infections in the US continue Vast majority of infections are sexually acquired Condoms work but are
More informationClinical Education Initiative PRE-EXPOSURE PROPHYLAXIS. Speaker: Jeffrey Kwong, DNP, MPH
Clinical Education Initiative Support@ceitraining.org PRE-EXPOSURE PROPHYLAXIS Speaker: Jeffrey Kwong, DNP, MPH 10/21/2015 Pre-exposure Prophylaxis [video transcript] 00:00:05 - [Rob] Good afternoon everyone.
More informationGuidelines for Implementing Pre-Exposure Prophylaxis For The Prevention of HIV in Youth Peter Havens, MD MS Draft:
Guidelines for Implementing Pre-Exposure Prophylaxis For The Prevention of HIV in Youth Peter Havens, MD MS Draft: 10-2-2015 Clinical studies demonstrate that when a person without HIV infection takes
More informationPrEP in the Real World: Clinical Case Studies
PrEP in the Real World: Clinical Case Studies Kevin L. Ard, MD, MPH April 30, 2015 Massachusetts General Hospital, National LGBT Health Education Center Continuing Medical Education Disclosure Program
More informationBiomedical Prevention Update Thomas C. Quinn, M.D.
Biomedical Prevention Update Thomas C. Quinn, M.D. Associate Director of International Research National Institute of Allergy and Infectious Diseases Director, Johns Hopkins Center for Global Health Global
More informationHIV Clinical Update- HIV prevention
HIV Clinical Update- HIV prevention 18 th Australian and New Zealand Conference on Haemophilia and Rare Bleeding Disorders, Melbourne October 13 th 2017 Edwina Wright Disclosures None in the past 12 months
More informationUsing anti-hiv drugs for prevention
Using anti-hiv drugs for prevention Highlights from AIDS 2012 (and 2 nd International Workshops on Treatment as Prevention) Tim Rogers, trogers@catie.ca Using anti-hiv Drugs for Prevention Outline Treatment
More informationHIV: Pregnancy in Serodiscordant Couple. Dr Chow TS ID Clinic HPP
HIV: Pregnancy in Serodiscordant Couple Dr Chow TS ID Clinic HPP Sexual Reproductive Health and Rights The recognition of the sexual and reproductive health and rights (SRHR) of all individuals and couples
More informationPre-exposure Prophylaxis and Primary Care
Pre-exposure Prophylaxis and Primary Care National Latino HIV and Hepatitis C Conference June 7 th, 2016 Allison Finkenbinder, MSN, WHNP-BC Denver Prevention Training Center Who s in the audience? Disclosures
More informationPEP and PREP. Dr David Hawkins Chelsea and Westminster Hospital
PEP and PREP Dr David Hawkins Chelsea and Westminster Hospital Opportunities for biomedical interventions YEARS HOURS 72 HOURS YEARS Prior to exposure Exposure (pre-coital/ coital) Exposure (pre-coital/
More informationUnderstanding the Results of VOICE
CONTACT: Lisa Rossi +1-412- 916-3315 (mobile) or +27-(0)73-323-0087 (through 7 March) rossil@upmc.edu About VOICE Understanding the Results of VOICE VOICE Vaginal and Oral Interventions to Control the
More informationClinical Education Initiative TITLE: UPDATE ON MSM SEXUAL HEALTH. Speaker: Maureen Scahill, MS NP
Clinical Education Initiative Support@ceitraining.org TITLE: UPDATE ON MSM SEXUAL HEALTH Speaker: Maureen Scahill, MS NP 1/25/2017 2/10/2017 Update on MSM Sexual Health [video transcript] 00:00:08 - [Maureen]
More informationModernization of North Carolina s HIV control measures
Modernization of North Carolina s HIV control measures North Carolina Division of Public Health Victoria Mobley, MD MPH Evelyn Foust, MPH CPM Agenda Introduction Summary of scientific evidence used to
More informationCROI 2015: HIV Prevention Updates
NORTHWEST AIDS EDUCATION AND TRAINING CENTER CROI 2015: HIV Prevention Updates Ruanne V Barnabas, MBChB Dphil Global Health and Medicine University of Washington a bevy of new studies quelled most remaining
More informationPrEP: Getting to the Tipping Point
PrEP: Getting to the Tipping Point Harvey J Makadon, MD The National LGBT Health Education Center, The Fenway Institute Professor of Medicine, Harvard Medical School April 15, 2016 Continuing Medical Education
More informationGovernment of Canada Federal AIDS Initiative Milestones
HIV in Canada: Trends and Issues for Advancing Prevention, Care, Treatment and Support Through Knowledge Exchange Michael R Smith, Senior Policy Advisor, Programs and Coordination Division, Centre for
More informationHow to order generic PrEP online Find a doctor who prescribes PrEP Learn how to prescribe PrEP Information for doctors. What is PrEP?
4 What is PrEP? 6 Who will benefit from PrEP? 7 Men (cis or trans) and trans women who have sex with men Partners of people living with HIV 8 Take the quiz: Is PrEP right for me? What are the options for
More informationFertility Desires/Management of Serodiscordant HIV + Couples
Fertility Desires/Management of Serodiscordant HIV + Couples William R. Short, MD, MPH Assistant Professor of Medicine Division Of Infectious Diseases Jefferson Medical College of Thomas Jefferson University
More informationThe HIV Prevention Pill: The State of PrEP Science and Implementation
The HIV Prevention Pill: The State of PrEP Science and Implementation James Wilton Coordinator, Biomedical Science of HIV Prevention CATIE December 11 th, 2014 Overview 1. The Basics 2. A review of the
More informationThe HIV Prevention Pill: The State of PrEP Science and Implementation. James Wilton Coordinator, Biomedical Science of HIV Prevention CATIE
The HIV Prevention Pill: The State of PrEP Science and Implementation James Wilton Coordinator, Biomedical Science of HIV Prevention CATIE Overview 1. The Basics 2. A review of the science 3. An update
More informationAntiretroviral Drugs for HIV Seronegative People: It works in trials, what about the real world?
Antiretroviral Drugs for HIV Seronegative People: It works in trials, what about the real world? Lut Van Damme 11 Oct 2012 1 Disclaimer Gilead donated the study product for the FEM-PrEP trial I participated
More informationPrEP Home Checklist v1.0
PrEP Home Checklist v1.0 Every Visit o Risk Reduction Counseling o Appropriate referrals and follow-ups (SW, Pharmacy, et al.) o For those on PrEP: o Assessment of PrEP adherence, side effects, ongoing
More informationHIV Pre- Exposure Prophylaxis
HIV Pre- Exposure Prophylaxis KNOWLEDGE AND ATTITUDES IN NORTH QUEENSLAND GENERAL PRACTITIONERS Principle Investigator: William Lane Co-Supervisor 1: Professor Clare Heal Co-Supervisor 2: Dr Jennifer Banks
More informationBHIVA Satellite Symposium. Tougher Times: Adapting to Increasing Demand with Declining Resources
BHIVA Satellite Symposium Tougher Times: Adapting to Increasing Demand with Declining Resources Monday 24 July 2017 Dr Nneka Nwokolo 56 Dean Street, Chelsea and Westminster Hospital, London Speaker Name
More informationHIV. The Role of Pre-Exposure Prophylaxis (PrEP) for the Prevention of HIV. Brief History of HIV AIDS. Global HIV Infection.
The Role of Pre-Exposure Prophylaxis (PrEP) for the Prevention of HIV HIV Sarah Kemink, PharmD, AAHIVP WMSHP Spring Seminar 5/05/2015 AIDS CD4 less than 200 +/- AIDS-defining illness Most common: Candidiasis
More informationFaculty/Presenter Disclosure. HIV Update Outline. Undetectable = Untransmissable HTPN 052. Partner Opposites attract 9/28/2018
Faculty/Presenter Disclosure HIV Update 2018 Dr. Joss de Wet Clinical Assistant Professor Family Medicine UBC Faculty: Joss de Wet Relationships with financial sponsors: Speakers Bureau/Honoraria: Gilead,
More informationA Sex-informed Framework for HIV Prevention. Robert M. Grant, M.D., M.P.H. Betty Jean and Hiro Ogawa Endowed Investigator
A Sex-informed Framework for HIV Prevention Robert M. Grant, M.D., M.P.H. Betty Jean and Hiro Ogawa Endowed Investigator Disclosures Gilead Sciences donated study medication to US NIH for trials that I
More informationHIV & Condomless Sex - What is the Risk? Why Not? Alan J. Taege, MD Assistant Professor of Medicine Department of Infectious Disease Cleveland Clinic
HIV & Condomless Sex - What is the Risk? Why Not? Alan J. Taege, MD Assistant Professor of Medicine Department of Infectious Disease Cleveland Clinic Yes No What s Going on Out There? Condomless Sex among
More informationGay Community Periodic Survey: Perth 2016
Gay Community Periodic Survey: Perth 06 Never Stand Still Art Social Sciences Centre for Social Research in Health Evelyn Lee Limin Mao Matt Creamer Sue Laing Jude Comfort Garrett Prestage Iryna Zablotska
More informationThe Science behind Preexposure Prophylaxis (PrEP) Yunus Moosa Department of Infectious Diseases UKZN
The Science behind Preexposure Prophylaxis (PrEP) Yunus Moosa Department of Infectious Diseases UKZN 1 Ongoing HIV transmission despite expanding access to ART SA 18 16 14 12 10 8 6 4 2 0 Treatment exposure
More informationFast-Track Your PrEP Knowledge. Jonathan Fritz PrEP Coordinator MDHHS Division of HIV and STD Programs
Fast-Track Your PrEP Knowledge Jonathan Fritz PrEP Coordinator MDHHS Division of HIV and STD Programs Session objectives Increase knowledge of the basics of PrEP and clinical procedures Identify financial
More informationGetting Prepped for PrEP. Ken Ho, MD, MPH World AIDS Day
Getting Prepped for PrEP Ken Ho, MD, MPH World AIDS Day Objectives HIV epidemiology What is PrEP? Does it Work? Who gets PrEP? How do I prescribe PrEP What to do at the first visit? What to do at follow
More informationRecent Breakthroughs in HIV Prevention for Men who Have Sex with Men and Transgender Populations
Recent Breakthroughs in HIV Prevention for Men who Have Sex with Men and Transgender Populations Kevin Ard, MD, MPH Brigham and Women s Hospital The Fenway Institute Boston, MA Funding: The New England
More informationClinical and Public Health Policy Implications of Findings that:
Clinical and Public Health Policy Implications of Findings that: Adherence to HIV Medications and Emotional/Physiological Coping with Stress are Independently Associated with Specific Five-Year Outcome
More informationNATIONAL SURVEY OF YOUNG ADULTS ON HIV/AIDS
NATIONAL SURVEY OF YOUNG ADULTS ON HIV/AIDS Kaiser Family Foundation November 30, 2017 Introduction More than three and a half decades have passed since the first case of AIDS. An entire generation has
More informationRevised MEN S ATTITUDE SURVEY (the RMAS)
VISIT #: Visit Date: As before, this questionnaire is intended to assess and track your attitudes, beliefs and other factors that might influence your sexual and other risky or risk-reduction practices
More informationPrEP Active Referrals at the Chicago Dept. of Public Health: past, present, and future. Ramona Bhatia, MD MS Supervising Physician HIV/STI 9/29/16
PrEP Active Referrals at the Chicago Dept. of Public Health: past, present, and future Ramona Bhatia, MD MS Supervising Physician HIV/STI 9/29/16 Burden of HIV in Chicago, 2014 22,875 people living with
More informationPrEP Dosing Strategies
PrEP Dosing Strategies Outline o Background PrEP absorption and tissue penetration o Oral versus topical o Lead in and lead out dosing Time to protection o Cycling on and off PrEP o Balancing toxicity
More informationPrEP: Pre Exposure Prophylaxis
PrEP: Pre Exposure Prophylaxis Lyn Stevens, NP, MS, ACRN Deputy Director Office of the Medical Director NYS Department of Health, AIDS Institute Faculty Disclosure Lyn Stevens No relationships to disclose
More informationBiomedical HIV Prevention & PrEP Pre exposure Prophylaxis 2013
Biomedical HIV Prevention & PrEP Pre exposure Prophylaxis 2013 Community Education Team The AIDS Institute/AIDS Alliance Be the Generation to End the AIDS Epidemic bethegeneration.nih.gov www.aids-alliance.org/education/vaccine
More informationHIV Prevention Pearls
HIV Prevention Pearls Meghan Rothenberger, MD Assistant Professor Division of Infectious Diseases University of Minnesota Director, Youth and AIDS Projects October 27, 2017 Disclosure Information I have
More informationProviding Good Care to People Living with HIV
National Ambulance LGBT Network Providing Good Care to People Living with HIV An Ambulance Service Resource Pack Supporting Lesbian, Gay, Bisexual, Trans staff, patients and communities A partnership of
More information27. So, we hope that today's presentation provides some timely information that can help you serve your Title X clients.
Hi, everyone. We're excited to have you all with us today. This is Katie Saul from the Title X Family Planning National Training Center. And I'm happy to welcome you all to today's webinar. Exploring What
More informationHIV Pre-Exposure Prophylaxis (HIV PrEP) in Scotland
HIV Pre-Exposure Prophylaxis (HIV PrEP) in Scotland An update for registered practitioners November 2017 Rationale for resource This resource is designed to support registered practitioners involved in
More informationNational Survey of Young Adults on HIV/AIDS
REPORT National Survey of Young Adults on HIV/AIDS November 2017 Kaiser Family Foundation Introduction More than three and a half decades have passed since the first case of AIDS. An entire generation
More informationAn evaluation of the STD profiles and safe sex practices of a sample of swingers
An evaluation of the STD profiles and safe sex practices of a sample of swingers Presented by: Edward M. Fernandes, Ph.D. Assistant Professor of Psychology Barton College, North Carolina George Gaither,
More informationOral Versus Injectable Delivery, Impact on Adherence/Tolerability
Oral Versus Injectable Delivery, Impact on Adherence/Tolerability 2 nd European HIV Forum Ian McGowan MD DPhil FRCP University of Pittsburgh, PA, USA Glasgow, 22 nd October, 2016 Overview Why do we need
More informationCONTENTS. New Zealand s personal importation scheme for medicines. What is PrEP? Who will benefit from PrEP? Sex between men
CONTENTS 4 What is PrEP? 6 Who will benefit from PrEP? Sex between men 7 Sex between men and women 8 What happens when I start on PrEP? 9 What if I want to stop using PrEP? Where can I get PrEP in New
More informationNovel HIV Prevention Methods for Women
Novel HIV Prevention Methods for Women State of the art injectables, rings, and antibody-mediated prevention Nyaradzo M Mgodi (MBChB, MMed) Principal Investigator University of Zimbabwe- College of Health
More information1 IN 2 BLACK MSM 1 IN 4 LATINO MSM. and. will be diagnosed with HIV within their lifetime.
MODULE 2 FACULTY 1 IN 2 BLACK MSM and 1 IN 4 LATINO MSM will be diagnosed with HIV within their lifetime. Young Black MSM account for MORE THAN HALF of new infections among young MSM more than any other
More informationPrevenção do HIV e o papel dos inibidores da integrasse
Prevenção do HIV e o papel dos inibidores da integrasse Pep Coll AIDS Research Institute-IrsiCaixa Fight AIDS Foundation BCN Checkpoint 22 Agosto 2018 DISCLOSURES I have received a research grant from
More informationDominic Chow, MD, PhD, MPH, Hawaii Center for AIDS Kunane Dreier, Prevention, Life Foundation Kekoa Kealoha, Hawaii Island HIV/AIDS Foundation Alexis
Dominic Chow, MD, PhD, MPH, Hawaii Center for AIDS Kunane Dreier, Prevention, Life Foundation Kekoa Kealoha, Hawaii Island HIV/AIDS Foundation Alexis Charpentier, Harm Reduction Services Branch, Hawaii
More informationPrEP for Women. Together, we can change the course of the HIV epidemic one woman at a time.
PrEP for Women Together, we can change the course of the HIV epidemic one woman at a time. #onewomanatatime #thewellproject What Is PrEP? PrEP stands for Pre- Exposure Prophylaxis: Prophylaxis: Taking
More informationWhat s in the Biomedical Prevention Pipeline
What s in the Biomedical Prevention Pipeline HIV Endgame: Closing Gaps in the Care Cascade Toronto, 24 th October 2016 Ian McGowan MD DPhil FRCP University of Pittsburgh Pittsburgh, PA, USA Presenter Disclosure
More informationHIV & THE MEDICAL HOME A NEW FRONT FOR GETTING TO ZERO. Brent K. Sugimoto, MD, MPH Kaiser Permanente. 29th Annual East Bay HIV Update June 3, 2016
HIV & THE MEDICAL HOME A NEW FRONT FOR GETTING TO ZERO 29th Annual East Bay HIV Update June 3, 2016 Brent K. Sugimoto, MD, MPH Kaiser Permanente Photo Credit: C. GoldsmithContent Providers: CDC/ C. Goldsmith,
More informationUpdate on Biomedical Prevention. Thomas C. Quinn, MD, MSc
Update on Biomedical Prevention Thomas C. Quinn, MD, MSc Associate Director of International Research National Institute of Allergy and Infectious Diseases Director, Johns Hopkins Center for Global Health
More informationAddressing STIs among MSM: A Clinical and Public Health Update
Addressing STIs among MSM: A Clinical and Public Health Update Kevin L. Ard, MD, MPH National LGBT Health Education Center, Fenway Institute Infectious Disease Division, Massachusetts General Hospital
More informationPrEP 201: Beyond the Basics
NORTHWEST AIDS EDUCATION AND TRAINING CENTER PrEP 201: Beyond the Basics Joanne Stekler, MD MPH Associate Professor of Medicine University of Washington February 19, 2015 Disclosures and Disclaimers I
More informationETHICS IN HIV PREVENTION RESEARCH IN THE NEW ERA OF
ETHICS IN HIV PREVENTION RESEARCH IN THE NEW ERA OF PrEP MTN Regional Meeting Cape Town 20 September 2017 Dhevium Govender South African Medical Research Council HIV Prevention Research Unit Quality/Regulatory
More informationHoward Brown Health Center
Howard Brown Health Center STI Annual Report, Background Howard Brown is the largest LGBT health center in the Midwest, providing comprehensive medical and behavioral health services to over, adults and
More informationHIV and the Buckeye State
HIV and the Buckeye State A Primer Karen Rubin, MPH Senior Community Engagement Coordinator rubin@ohioaidscoalition.org 614-340-6707 HIV 101 WHAT IS HIV? Human- can only infect humans Immunodeficiencyweakens
More informationOR: Steps you can take in the clinic to prevent HIV infections
Implementing Changes to Reduce HIV Incidence: Synergies between Public Health and Primary Care Kevin Ard, MD, MPH Brigham and Women s Hospital, Massachusetts General Hospital, and the Fenway Institute
More informationHIV Prevention among Women
HIV Prevention among Women Assistant Professor of Medicine Division of Infectious Diseases Baylor College of Medicine Disclosures: Gilead Sciences - Scientific Advisory Board; Investigatorinitiated research
More informationOn the Horizon for Consideration: Biomedical Advances in HIV Prevention
On the Horizon for Consideration: Biomedical Advances in HIV Prevention Francisco Ruiz, MS Senior Manager, National Alliance of State and Territorial AIDS Directors New Jersey Governor's Advisory Council
More information11/8/2016. The Challenge of HIV Treatment
You Mean I Have to Talk About...Sex? Trudy Larson, MD Professor and Director, School of Community Health Sciences Medical Director, Nevada AIDS Education and Training Center Nat l HIV/AIDS Strategy Goals
More informationPrEP efficacy the evidence
PrEP efficacy the evidence Dr Michael Brady Consultant, HIV and Sexual Health King s College Hospital, London Medical Director Terrence Higgins Trust PrEP Pre-exposure prophylaxis Tenofovir and emtricitabine
More informationPrEP (Pre-Exposure-Prophylaxis) for sub-saharan African migrants in Europe?
PrEP (Pre-Exposure-Prophylaxis) for sub-saharan African migrants in Europe? OFFERING PrEP TO ALL GROUPS AT INCREASED RISK FOR HIV. A RESEARCH AGENDA Jasna Loos HIV and Sexual Health Department of Public
More informationSouth African Guidelines for the Safe Use of. Dr. Oscar Radebe
South African Guidelines for the Safe Use of PrEP in MSM Dr. Oscar Radebe Background Globally MSM(men who have sex with men) have been disproportionately at high risk of HIV transmission. Biological &
More informationLong Acting HIV Drugs for Prevention: what are the data? Pep Coll AIDS Research Institute-IrsiCaixa Fight AIDS Foundation BCN Checkpoint
Long Acting HIV Drugs for Prevention: what are the data? Pep Coll AIDS Research Institute-IrsiCaixa Fight AIDS Foundation BCN Checkpoint DISCLOSURES I have received a research grant from Gilead Sciences
More informationHPTN 061: The Brothers Study
HPTN 061: The Brothers Study PRESENTED BY: RISHA IRVIN, MD/MPH, FORMER HPTN SCHOLAR (SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH) AND CURRENT MEMBER OF THE JOHNS HOPKINS HPTN SITE ON BEHALF OF HPTN 061 Background
More informationMANITOBA HIV REPORT 2015
MANITOBA HIV REPORT 2015 The Manitoba HIV Program provides information, specialized care, treatment, and support to approximately 1,250 people living with HIV across the province. The Program has two Winnipeg-based
More informationSupplementary Material Table 5. Ongoing PrEP studies among young key population, young people, and key populations. Age range. Study name and location
Supplementary Material Table 5. Ongoing PrEP studies among young key population, young people, and key populations Study name and location ADAPT (HPTN 067) South Africa, Thailand, US (Harlem) Bangkok Tenofovir
More informationExtragenital Gonorrhea and Chlamydia among MSM
Extragenital Gonorrhea and Chlamydia among MSM Laura Quilter, MD Infectious Disease and STD PTC Fellow University of Washington Division of Allergy and Infectious Diseases 3/28/2016 uwptc@uw.edu uwptc.org
More informationSTIs in the Indian Country
STIs in the Indian Country Multiple STI s and Risk for HIV Ryan Kreisberg, MPH Senior Epidemiologist, PRISM Data Manager Agenda STI/HIV Trends across the US and Arizona STIs in the Indian Country Multiple
More informationPre-Exposure Prophylaxis (PrEP) Stefanie La Manna, PhD, MPH, APRN, FNP-C, AGACNP-BC October 12, 2018
Pre-Exposure Prophylaxis (PrEP) Stefanie La Manna, PhD, MPH, APRN, FNP-C, AGACNP-BC October 12, 2018 Disclosures I have no financial disclosures to report Objectives Identify the need for HIV prevention
More informationWhat s new in sexually-transmitted infections?
What s new in sexually-transmitted infections? Kevin L. Ard, MD, MPH National LGBT Health Education Center, Fenway Institute Infectious Disease Division, Massachusetts General Hospital Director, Genitourinary
More informationPrEP in young African women: Rationale & lessons from HPTN 082
PrEP in young African women: Rationale & lessons from HPTN 082 Connie Celum MD MPH Departments of Global Health and Medicine University of Washington Disproportionate Success in HIV Epidemic Control by
More informationChapter 7 Reproductive Tract Infections and HIV/AIDS
Chapter 7 Reproductive Tract Infections and HIV/AIDS Introduction Reproductive Tract Infections (RTIs) Infections caused by a variety of organisms that affect upper and/or lower reproductive tracts Most
More informationPrEP and npep for HIV Prevention. Harry Rosado-Santos MD, FACP Associate Professor UU School of Medicine
PrEP and npep for HIV Prevention Harry Rosado-Santos MD, FACP Associate Professor UU School of Medicine Case Study A 26 y/o M presents for routine asymptomatic screening for sexually transmitted infections
More informationAttendees will be able to:
A. Kay Kalousek, DO, MS, FACOFP kaysdroid@gmail.com April 21, 2017 Attendees will be able to: List strategies for prevention of HIV infection Explain the pharmacology of TDF/FTC related to PrEP Assess
More informationReady, set, PrEP! Renee-Claude Mercier PharmD, PhC, BCPS-AQ ID, FCCP Professor of Pharmacy and Medicine University of New Mexico
Ready, set, PrEP! Renee-Claude Mercier PharmD, PhC, BCPS-AQ ID, FCCP Professor of Pharmacy and Medicine University of New Mexico Objectives At the end of the talk the audience should be able to: Understand
More informationHIV Prevention Strategies HIV Pre-exposure prophylaxis
HIV Prevention Strategies HIV Pre-exposure prophylaxis Michael Martin, MD, MPH Director HIV Research Program Thailand MOPH U.S. CDC Collaboration The findings and conclusions in this presentation are those
More informationPre-exposure prophylaxis (PrEP)
FACTSHEET Pre-exposure prophylaxis (PrEP) Summary Pre-exposure prophylaxis, or PrEP, is a way for an HIV-negative person who is at risk of HIV infection to reduce their risk of becoming infected with HIV.
More informationClinical Education Initiative THE ROLE OF THE PRIMARY CARE CLINICIAN IN HIV CARE. Speaker: Antonia Urbina, MD
Clinical Education Initiative Support@ceitraining.org THE ROLE OF THE PRIMARY CARE CLINICIAN IN HIV CARE Speaker: Antonia Urbina, MD 2/1/2017 The Role of the Primary Care Clinician in HIV Care [video transcript]
More informationREVIEW OF PREP GUIDELINES: A PRIMER FOR THE PRIMARY CARE PRACTITIONER ANTONIO E. URBINA, MD. PrEP Webinar Series
REVIEW OF PREP GUIDELINES: A PRIMER FOR THE PRIMARY CARE PRACTITIONER ANTONIO E. URBINA, MD PrEP Webinar Series Disclosure Speaker s Bureau: Gilead, VIIV, BMS, Merck, Serono LEARNING OBJECTIVES: 1. Review
More information