Rate scazute de raspuns virusologic rapid la pacienti infectati cronic VHC naivi din punct de vedere terapeutic
|
|
- Lorin Stafford
- 6 years ago
- Views:
Transcription
1 Rate scazute de raspuns virusologic rapid la pacienti infectati cronic VHC naivi din punct de vedere terapeutic Camelia Sultana, Gabriela Oprisan, Gratiela Tardei, Simona Ruta si Echipa Proiectului HEPGEN UMF "Carol Davila" Bucuresti, Institutul de Virusologie "St S Nicolau", INCDMI "Cantacuzino", Spitalul de boli infectioase si tropicale "Victor Babes"
2 Background VIRUS Viral load HCV Genotype Mutations HOST Genetic Factors (IL28B, IP-10, scd26) Sex, Age Romania - standard terapeutic = Interferon alfa pegylat si ribavirina (48 de saptamani). Genotipul 1b prevalent (92.6%*, 93.46%**) Rate inalte de raspuns virusologic sustinut (55-60%) in studii clinice din Romania Environamental Factors Alcohol / drugs Co-infections (HIV, HVB) OBIECTIVE Evaluarea impactului replicarii virale si a factorilor genetici ai gazdei asupra ratei de succes terapeutic. ultana, Oprişan, Szmal, Vagu, Temereanca, Dinu, Teleman, Ruta. Molecular Epidemiology of Hepatitis C Virus Strains from Romania. JGLD, 2011, 20(3) Grigorescu M. HCV genotype 1 is almost exclusively present in Romanian patients with chronic hepatitis C. J Gastrointestin Liver Dis 2009; 18(1):
3 Materiale si metode Studiu prospectiv SNP IL28B (rs , Custom TaqMan Single Nucleotide Polymorhism Genotyping Assays, Applied Biosystem) 73 de pacienti VHC cronic genotip 1b netratati anterior Nivelul plasmatic al IP-10 (Interferongamma inducible protein 10) - Quantikine Human CXCL10/IP-10, R&DSystems Replicare virala VHC la momentul 0 sapt 4 (RVR) si sapt 12 (EVR) de la initierea tratamentului Cobas Ampliprep G/CTM HCV quant., vers 2.0,Roche; Fibroza hepatica (FIBROSCAN)
4 Rezultate femei %, varsta medie = 49.2 ± 10.9 ani, viremia VHC baseline ± 2.9 x 10 UI / ml (6.1 log UI/ml); 28.9% - viremie VHC initiala < UI/ml. 6 Viremie VHC / varsta VL HCV age
5 SNP IL 28B VHC inductia interferonului tip III la nivelul hepatocitelor umane corelat cu nivelul hepatic al expresiei genelor ISG (IFNstimulated genes). asocierea dintre SNP IL28, nivelul de ISG si procentul de raspuns virusologic din infectia VHC SNP IL28B (rs ) este asociat cu RVS la regimul terapeutic standard SNP IL28B (rs ) este asociat cu clearance si rate diferite de evolutie spre ciroza hepatica a pacientilor
6 SNP IL28B rs heterozigoti CT % homozigotismul - egal 17.8% CC si 17.8 % TT) Adapted from Macmillan Publishers Ltd: Nature, Thomas, et al, SNP rs variaza ca prevalenta in diferite populatii. Thomas et al, rs SNP pe 2371 subiecti din 51 populatii distincte. prevalenta CC (asociat cu clearance HCV) si TT (asociat cu persistenta infectiei). Asia (Est and Sud) cea mai scazuta prevalenta de alele TT asociate cu persistenta infectiei, Europa - prevalenta intermediara, Africa Sub-Sahariana- prevalenta inalta TT
7 Rezultate RVR-raspuns virusologic rapid (4 s tratament) 12.3% - ating RVR 38,5% CC vs. 8,5% CT vs. 0% TT, p=0.005 Chi-squared test % 80.00% 70.00% EVR-raspuns virusologic timpuriu (12 s de tratament) 52.4% - ating EVR 90% CC vs CT% vs. 34% TT, p=0.02, Chi-squared test RVR la tineri, au incarcare virala baseline mai mica grad de fibroza mai scazut, nu difera din punct de vedere al IP % 50.00% 40.00% 30.00% 20.00% 10.00% 0.00% CC CT TT RVR 38.50% 8.50% 0% EVR 90% 39.10% 34%
8 IP-10 / CXCL10 proteina inductibila de interferonul gama, chemokina cu activitate chemotactica pentru limfocite T, celule NK si monocite, rol imunomodulator complex, corelata cu inflamatia hepatica si caile imunomodulatoare in parenchimul hepatic. Valoare medie IP-10 = ±265 pg/ml ( pg/ml).
9 IP 10 / ARN VHC la 12 S EVR au incarcare virala baseline mai mica grad de fibroza mai scazut, difera din punct de vedere al IP-10. IP 10 coreleaza negativ cu diferenta de viremie VHC dintre T0 si T12 (p=0.0017, r = ).
10 IP 10 / fibroza hepatica (FIBROSCAN) IP 10 / FibroScan normal - 5,5±1,6kPa. F1< 7kPa F2 > 7,1kPa F3 > 9,5kPa F4 (ciroza)>12,5kpa pentru IP-10<400pg/ml - VM FIBROSCAN: 7.8 ± 3.4 (4-15) pentru IP-10>400pg/ml VM FIBROSCAN : 9.5 ± 5.4 ( ) p=0.05, Unpaired t test, Graph Pad InStat
11 Concluzii O proportie importantă de pacienti infectati VHC din România prezinta factori de predictie negativa pentru evolutia infectiei VHC (genotipul 1, replicare inalta VHC, fibroza hepatica avansata, proportie scazuta de SNP IL28B homozigot CC si au obtinut o rata scazuta de RVR (sapt 4); totusi rata EVR este de 4 ori mai mare. RVR si EVR sunt corelate semnificativ statistic cu genotipul homozigot CC al IL28B. Datorita ratei scazute de RVR - considerat a fi un marker predictiv important pentru succesul tratamentului - este necesara urmarirea cineticii replicarii virale pe toata durata tratamentului, pentru definirea pacientilor cu sanse maxime de obtinere a raspunsului virusologic sustinut. Desi necorelat cu RVR, un nivel inalt al IP-10 (>400 pg/ml) poate fi considerat un marker fiabil si ieftin pentru evaluarea severitatii bolii hepatice, dar si a ratei de EVR (sapt 12) la pacientii infectati VHC.
12 PN-II-PT-PCCA , Proiect nr. 88/2012: Investigarea unor markeri virali şi de gazda corelati cu lipsa de raspuns la tratamentul anti-viral in hepatita cronica cu virus C (HepGen) People think focus means saying yes to the thing you ve got to focus on. But that s not what it means; it means saying no to the hundred other good ideas Steve Jobs
Investigarea unor markeri virali si de gazda corelati cu lipsa de raspuns la tratamentul anti-viral în hepatita cronica cu virus C (HepGen)
Investigarea unor markeri virali si de gazda corelati cu lipsa de raspuns la tratamentul anti-viral în hepatita cronica cu virus C (HepGen) Gabriela Oprisan INCDMI Cantacuzino si consortiul proiectului
More informationTrends in Hepatitis C Virus Infection Therapy: Protease Inhibitors a Step Forward in the Era of Direct Acting Antivirals
Trends in Hepatitis C Virus Infection Therapy: Protease Inhibitors a Step Forward in the Era of Direct Acting Antivirals CRISTINA POPESCU 1, 2, SMARANDA GLIGA 1, VICTORIA ARAMĂ 1, 2 1 Matei Bals National
More informationRolul Hepcidinei in Anemia din bolile cronice o abordare translationala. Grigoras Adelina Grigorescu Beatrice-Adriana Hluscu Otilia
Rolul Hepcidinei in Anemia din bolile cronice o abordare translationala Grigoras Adelina Grigorescu Beatrice-Adriana Hluscu Otilia Anemia din bolile cronice definitii, cauze ACD anemia cu a doua rata de
More informationSex differences in HIV-1 viral load and absolute CD4 cell count in long term survivors HIV-1 infected patients from Giurgiu, Romania
Revista Română de Medicină de Laborator Vol. 21, Nr. 2/4, Iunie 2013 217 Short communication DOI: 10.2478/rrlm-2013-0010 Sex differences in HIV-1 viral load and absolute CD4 cell count in long term survivors
More informationUNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA DOCTORAL SCHOOL DOCTORAL THESIS
UNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA DOCTORAL SCHOOL DOCTORAL THESIS PHARMACOGENETICS AND THE APPLICATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN RESPONSE TO PEGYLATED INTERFERON AND RIBAVIRIN
More informationThe role of physical training in lowering the cardio-metabolic risk
The role of physical training in lowering the cardio-metabolic risk Timea Szasz 1, Eugen Bota 2, Lucian Hoble 3 Abstract The cardio-metabolic risk represents the overall risk of developing type 2 diabetes
More informationThe effect of lamivudine- versus tenofovir-containing antiretroviral regimen on hepatitis B infection in a cohort of HIV infected long term survivors
The effect of lamivudine- versus tenofovir-containing antiretroviral regimen on hepatitis B infection in a cohort of HIV infected long term survivors Aura Temereanca 1,2, Luminita Ene 3, Adelina Rosca
More informationElectroencephalography (EEG) alteration in Autism Spectum Disorder (ASD)
Electroencephalography (EEG) alteration in Autism Spectum Disorder (ASD) FLORINA RAD 1, CAMELIA CIOBANU 2, GIANINA ANGHEL 3, IULIANA DOBRESCU 4 ABSTRACT There is a controversial relationship between Autism
More informationSpleen assessment by Acoustic Radiation Force Impulse Elastography (ARFI) for prediction of liver cirrhosis and portal hypertension
Original papers Medical Ultrasonography 2010, Vol. 12, no. 3, 213-217 Spleen assessment by Acoustic Radiation Force Impulse Elastography (ARFI) for prediction of liver cirrhosis and portal hypertension
More informationMETFORMIN IN PREVENTIA
METFORMIN IN PREVENTIA CRESTERII IN GREUTATE INDUSE DE TRATAMENTUL ANTIPSIHOTIC: O REVIZUIRE SISTEMATICA SI META-ANALIZA BMC Psyhiatry de Silva et al. BMC Psychiatry (2016) 16:341 DOI 10.1186/s12888-016-1049-5
More informationRELEVANCE OF TRANSIENT ELASTOGRAPHY (FIBROSCAN ) IN EVALUATION OF HEPATIC B VIRUS CHRONICALLY INFECTED PATIENTS
ORIGINAL ARTICLES RELEVANCE OF TRANSIENT ELASTOGRAPHY (FIBROSCAN ) IN EVALUATION OF HEPATIC B VIRUS CHRONICALLY INFECTED PATIENTS Diana Nicolita, Ioan Sporea, Roxana Sirli, Alexandra Deleanu, Adriana Tudora,
More informationSteatosis in Hepatitis C Virus Infection. Response to Anti-Viral Therapy
Steatosis in hepatitis C virus infection Steatosis in Hepatitis C Virus Infection. Response to Anti-Viral Therapy Paula Szanto 1, Mircea Grigorescu 1, Iuliana Dumitra 2, Alexandru Serban 2 1)3 rd Medical
More informationDetection and significance of PD-1.3 SNP (rs ) and IL28B SNP (rs ) in patients with current or past hepatitis B virus (HBV) infection
Detection and significance of PD-1.3 SNP (rs11568821) and IL28B SNP (rs12979860) in patients with current or past hepatitis B virus (HBV) infection Asterios Saitis 1, Nikolaos K. Gatselis 1, Kalliopi Azariadi
More informationSTRUCTURE OF FOOD CONSUMPTION IN ROMANIA DURING , COMPARED TO THE E.U.
Lucrări ştiinţifice Zootehnie şi Biotehnologii, vol. 40(2), (2007), Timişoara. STRUCTURE OF FOOD CONSUMPTION IN ROMANIA DURING 1990-2002, COMPARED TO THE E.U. STRUCTURA CONSUMULUI ALIMENTAR ÎN ROMÂNIA
More informationTreatment of Extrahepatic Manifestations of Chronic Hepatitis C Viral Infection A Challenge
REVIEWS Treatment of Extrahepatic Manifestations of Chronic Hepatitis C Viral Infection A Challenge C. TĂNĂSESCU, R. IONESCU Clinic of Internal Medicine, Colentina Hospital, C. Davila University of Medicine,
More informationFirst Journal of Homeopathic Pharmacology Published under the auspices of the Romanian Academy of Medical Sciences Volume II, N o 1, 2014
Anti-cytolytic homeopathic remedy, beneficial in chronic viral hepatitis Dumitru DOBRESCU (1), Adriana MOTOC (2), E. CEAUSU (3), Simona NEGRES(4) (1) MD, Pharmacology and Homeopathy Professor, Carol Davila
More informationTimisoara Physical Education and Rehabilitation Journal
DOI: 10.2478/tperj-2013-0006 Aspects Regarding the Beneficial Effect of Reflexology in Low Back Pain Şerban GLIGOR 1, Silviu ISTRATE 2 Abstract Reflexology is based on the digital pressure on certain reflex
More informationPREVALENCE OF FRAILTY SYNDROME AMONG TYPE 2 DIABETES MELLITUS ELDERLY PATIENTS
Rom. J. Gerontol. Geriatr., 2018, Vol. 7, No. 1, p. 25-31 PREVALENCE OF FRAILTY SYNDROME AMONG TYPE 2 DIABETES MELLITUS ELDERLY PATIENTS Raluca Nacu 1, Anna Marie Herghelegiu 1,2, Gabriel Ioan Prada 1,2
More informationBIOCHEMICAL MARKERS OF CALCIUM AND BONE METABOLISM IN THE MONITORING OF OSTEOPOROSIS TREATMENT
728 BIOCHEMICAL MARKERS OF CALCIUM AND BONE METABOLISM IN THE MONITORING OF OSTEOPOROSIS TREATMENT NOORA WAEL RASHEED 1, CARMEN GABRIELA BARBU 2 *, SUZANA FLOREA 2, GABRIELA BRANCEANU 2, SIMONA FICA 2,
More informationASSESSMENT OF VACCINE EFFICACY FOR DISEASES INCLUDED IN THE NATIONAL IMMUNIZATION PROGRAM FOR PRESCHOOL CHILDREN
THE JOURNAL OF PREVENTIVE MEDICINE 22; 1 (3): 45-55 ASSESSMENT OF VACCINE EFFICACY FOR DISEASES INCLUDED IN THE NATIONAL IMMUNIZATION PROGRAM FOR PRESCHOOL CHILDREN Angela Romaniuc, Anca Nistor, Cecilia
More informationImplications of Interleukins in Liver Fibrosis and Sustained Virological Response in Patients with Viral Hepatitis C
Modern Medicine 2016, Vol. 23, No. 2 ORIGINAL PAPERS Implications of Interleukins in Liver and Sustained Virological Response in Patients with Viral Hepatitis C Alexandra Floriana Rosu 1, Ovidiu Mircea
More informationRomanian Journal of Cardiology Vol. 26, No. 4, 2016
Romanian Journal of Cardiology ORGINAL ARTICLES Latent thyroid dysfunction in elderly patients with persistent nonvalvular atrial fibrillation Gabriela Silvia Gheorghe 1,2, Andreea Simona Hodorogea 1,2,
More informationPHYSICAL EXERCISES FOR DIABETIC POLYNEUROPATHY
STUDIA UBB EDUCATIO ARTIS GYMN., LIX, 4, 2014, pp. 101-106 (RECOMMENDED CITATION) PHYSICAL EXERCISES FOR DIABETIC POLYNEUROPATHY DOCU AXELERAD ANY 1*, DOCU AXELERAD DANIEL 2 ABSTRACT. Introduction: Chronic
More informationProiect IDEI 2008 C Baicus
Scaderea ponderala involuntara Proiect IDEI 2008 C Baicus www.baicus.ro 1. Studiu descriptiv, de evaluare a spectrului etiologic al SPI 2. Studiu diagnostic de evaluare a acuratetei TNF-alfa, IL- 1 beta,
More informationCentrul de Diagnostic şi Tratament Dr. Victor Babeş, Bucureşti 2. Universitatea de Medicină şi Farmacie Carol Davila, Bucureşti REZUMAT
ARTICOLE ORIGINALE 5 MONITORIZAREA INFECŢIILOR VIRALE POSTTRANSPLANT DE CELULE STEM HEMATOPOIETICE LA COPIL EXPERIENŢA CENTRULUI DE TRANSPLANT MEDULAR, INSTITUTUL CLINIC FUNDENI, BUCUREŞTI Monitoring posttransplant
More informationThe correlation between burn size and serum albumin level in the first 48 hours after burn injury
STUDII CLINICE The correlation between burn size and serum albumin level in the first 48 hours after burn injury Jurnalul Român de Anestezie Terapie Intensivă 2013 Vol.20 Nr.1, 5-9 The correlation between
More informationSerum ghrelin level is associated with cardiovascular risk score
Serum ghrelin level is associated with cardiovascular risk score DANA POP 1, P. PETER 1, ALEXANDRA DĂDÂRLAT 1, ADELA SITAR-TĂUT 1, D. ZDRENGHEA 1 1 Iuliu Haţieganu University of Medicine and Pharmacy,
More informationMODIFICĂRI ALE COMPOZIŢIEI CORPORALE LA PACIENŢII CU MUCOVISCIDOZĂ, DUPĂ PROGRAME COMPLEXE DE KINETOTERAPIE RESPIRATORIE
MODIFICĂRI ALE COMPOZIŢIEI CORPORALE LA PACIENŢII CU MUCOVISCIDOZĂ, DUPĂ PROGRAME COMPLEXE DE KINETOTERAPIE RESPIRATORIE CHANGES OF BODY COMPOSITION IN PATIENS WITH CYSTIC FIBRROSIS AFTER A COMPLEX PHYSIOTHERAPY
More informationAsociatia pentru Servicii Mobile de Ingrijire Paliativa in 2010
de Ingrijire Paliativa in 2010 Echipa SMIP Dr. Oana Donea, medic primar oncolog cu supraspecializare in ingrijire paliativa Luciana Negulescu, asistent medical principal Alina Lazar, asistent social Activitatile
More informationASSAYS UTILZIED TO MONITOR HCV AND ITS TREATMENT
ASSAYS UTILZIED TO MONITOR HCV AND ITS TREATMENT Mitchell L Shiffman, MD Liver Institute of Virginia Bon Secours Health System Richmond and Newport News, VA Liver Institute of Virginia Education, Research
More informationde cancer mamar: premiză pentru terapia metastazelor limfonodale
Limfangiogeneza în formele moleculare IDEI 345/2011 de cancer mamar: premiză pentru terapia metastazelor limfonodale Marius Raica Victor Babes University of Medicine and Pharmacy Timisoara, Romania Cancerul
More informationGHRELIN AS MARKER OF AGE ASSOCIATED CARDIO-VASCULAR DISEASE
FARMACIA, 2014, Vol. 62, 4 721 GHRELIN AS MARKER OF AGE ASSOCIATED CARDIO-VASCULAR DISEASE CLAUDIA BĂCANU, DENISA MARGINĂ*, NICULINA MITREA, NOORA WAEL RASHEED Carol Davila University of Medicine and Pharmacy,
More informationBlood Pressure Control and Quality of Life in Hypertensive Patients Treated with Amlodipine/Valsartan Fixed Dose Combination IMPROVE Study Results
Modern Medicine 2016, Vol. 23, No. 2 ORIGINAL PAPERS Blood Pressure Control and Quality of Life in Hypertensive Patients Treated with Amlodipine/Valsartan Fixed Dose Combination IMPROVE Study Results Oana
More informationRamona Maria Chendereş 1, Delia Marina Podea 1, Pavel Dan Nanu 2, Camelia Mila 1, Ligia Piroş 1, Mahmud Manasr 3
Psychosocial Factors in Late Life Depression Ramona Maria Chendereş 1, Delia Marina Podea 1, Pavel Dan Nanu 2, Camelia Mila 1, Ligia Piroş 1, Mahmud Manasr 3 Rezumat Cu toate ca depresia la varsta a treia
More informationMEDIC CENTER. Case 2
Case 2 Case history 57 year old Vietnamese man He lives in HCM city and works as a engineer The patient presented in July 2012 with fatigue Diagnosed with HCV in 2004 Negative for both HBV and HIV antibodies
More information240 TMJ 2007, Vol. 57, No. 4. Angelica Sink. abstract ORIGINAL ARTICLES
ORIGINAL ARTICLES INSULIN RESISTANCE IN PATIENTS WITH CHRONIC HEPATITIS C Angelica Sink REZUMAT Introducere: Insulinorezisten]a (IR) este factorul major n determinarea sindromului metabolic, fiind rezultatul
More informationPredictors of daytime sleepiness in patients with obstructive sleep apnea
Pneumologia Predictors of daytime sleepiness in patients with obstructive sleep apnea Predictori ai somnolenței diurne la pacienții cu sindrom de apnee în somn obstructiv Abstract Background. The main
More information29th Viral Hepatitis Prevention Board Meeting
29th Viral Hepatitis Prevention Board Meeting Madrid, November 2006 Treatment of chronic hepatitis C José M. Sánchez-Tapias Liver Unit Hospital Clínic University of Barcelona Spain CHRONIC HEPATITIS C
More informationPREVALENCE OF WHITE COAT EFFECT IN TREATED HYPERTENSIVE PATIENTS FROM CARAS SEVERIN COUNTY
ORIGINAL ARTICLES PREVALENCE OF WHITE COAT EFFECT IN TREATED HYPERTENSIVE PATIENTS FROM CARAS SEVERIN COUNTY Ecaterina Usurel 1, Sorin Pescariu 2,3, Daniel Brie 2, Constantin Erimescu 2, Stefan I. Dragulescu
More informationDurerea și fatigabilitatea în scleroza multiplă și impactul lor asupra prognosticului evolutiv al bolii
REZUMATUL TEZEI DE DOCTORAT Durerea și fatigabilitatea în scleroza multiplă și impactul lor asupra prognosticului evolutiv al bolii Doctorand Romana Homorodean Conducător de doctorat Prof. Dr. Lăcrămioara
More informationLIVER FUNCTION TESTS ANOMALIES IN PATIENTS WITH CHRONIC HEART FAILURE
: 145-149 Original Paper Copyright Celsius LIVER FUNCTION TESTS ANOMALIES IN PATIENTS WITH CHRONIC HEART FAILURE Camelia C. Diaconu 1, Alice Bãlãceanu 2, Daniela Bartoæ 1 1 Carol Davila University of Medicine
More informationVicente Soriano Department of Infectious Diseases
Predictors of Response to Hepatitis C Therapy Vicente Soriano Department of Infectious Diseases Hospital Carlos III, Madrid, Spain Diagnosis Therapy IL28B alleles Non-invasive liver fibrosis methods Viral
More informationand Molecular Genetics, Mike Petrovica Alasa 12-14, Belgrade, Serbia
ORIGINAL ARTICLES A quality of life assessment and the correlation between generic and disease-specific questionnaires scores in outpatients with chronic liver disease-pilot study MILICA OBRADOVIC 1, ZORAN
More informationLucrări ştiinţifice Zootehnie şi Biotehnologii, vol. 40(2), (2007), Timişoara
Lucrări ştiinţifice Zootehnie şi Biotehnologii, vol. 40(2), (2007), Timişoara GENOTYPIC PARAMETERS OF MILK PRODUCTION IN PRIMIPAROUS DAIRY ROMANIAN SPOTTED BREED FROM RESEARCH STATION AND AGRICULTURE DEVELOPMENT
More informationBINE ATI VENIT LA CATEDRA DE FIZIOPATOLOGIE! Asist. Dr. ORASAN MEDA SANDRA
BINE ATI VENIT LA CATEDRA DE FIZIOPATOLOGIE! Asist. Dr. ORASAN MEDA SANDRA Vom parcurge in acest semestru 14 lucrari practice: 20% din ele.. 3 absente posibile, dar care a) trebuie recuperate! b) trebuie
More informationASSESSMENT PRIOR TO TREATMENT DO WE NEED IL28B TESTING?
ASSESSMENT PRIOR TO TREATMENT DO WE NEED IL28B TESTING? DO WE NEED LIVER BIOPSY? Mitchell L Shiffman, MD Director Liver Institute of Virginia Bon Secours Health System Richmond and Newport News, VA POTENTIAL
More informationPopulation Viral Kinetic Modeling: SVR Prediction in HCV GT-3 Cirrhotic Patients With 24 Weeks of Daclatasvir + Sofosbuvir Administration
Population Viral Kinetic Modeling: SVR Prediction in HCV GT-3 Cirrhotic Patients With 24 Weeks of Daclatasvir + Sofosbuvir Administration Emi Tafoya, Yasong Lu, Melody Luo, Premkumar Narasimhan, Neelima
More informationPalestrica of the third millennium Civilization and Sport Vol. 14, no. 3, July-September 2013,
Palestrica of the third millennium Civilization and Sport Vol. 14, no. 3, July-September 2013, 186 190 in insulin-dependent patients Impactul exerciţiului fizic asupra riscului de producere a hipoglicemiei
More informationTratamiento de la Hepatitis C Rafael Esteban Hospital General Universitario Valle de Hebrón Barcelona
Tratamiento de la Hepatitis C Rafael Esteban Hospital General Universitario Valle de Hebrón Barcelona rrent HCV Therapy 8% % sustained response 6% 4% 2% % 54-61% 41% 34% 25% 16% 6% IFN 24w IFN 48w Peg
More informationThe Effect of Omega-3 Supplement on Serum Lipid Profile in Patients Undergoing Hemodialysis: A Randomized Clinical Trial
The Effect of Omega-3 Supplement on Serum Lipid Profile in Patients Undergoing Hemodialysis: A Randomized Clinical Trial MOSADEGH JABBARI 1, TERMEH KHOSHNEVIS 2, ARIA JENABI 1, FATEMEH YOUSEFI 3 1 Nephrology
More informationTECHNICAL SUMMARY OF RESULTS
TECHNICAL SUMMARY OF RESULTS 2008-004605-34 [Debio 025-HCV-205] Sponsor: Debiopharm S.A. Name of Finished Product: Tabulated Study Report (For National Authority Use Only) Name of Active Ingredient: Debio
More informationHEPATITIS C TREATMENT GUIDANCE
HEPATITIS C TREATMENT GUIDANCE These guidelines have been produced based on the NICE Guidance TA200 Peginterferon alfa and ribavirin for the treatment of chronic hepatitis c and the summaries of product
More informationFENOMENE AUTOIMUNE DE OVERLAP ÎN HEPATITELE CRONICE ALE COPILULUI
5 REFERATE GENERALE FENOMENE AUTOIMUNE DE OVERLAP ÎN HEPATITELE CRONICE ALE COPILULUI Dr. Daniela Păcurar, Dr. Gabriela Leşanu, Dr. Cristina Becheanu, Dr. Raluca Vlad, Prof. Dr. Dumitru Orăşeanu Spitalul
More informationHepatitis C Burden in Romania Evaluation 2018 Challenges Prof. Adrian Streinu-Cercel MD, PhD, HC
Hepatitis C Burden in Romania 2016-2017 Evaluation 2018 Challenges Prof. Adrian Streinu-Cercel MD, PhD, HC Carol Davila University of Medicine and Pharmacy National Institute For Infectious Diseases, Prof.
More informationHCR-20: PREDICTING RELAPSE IN PATIENTS DISCHARGED FROM FORENSIC PSYCHIATRY HOSPITAL
ORIGINAL ARTICLES HCR-20: PREDICTING RELAPSE IN PATIENTS DISCHARGED FROM FORENSIC PSYCHIATRY HOSPITAL 1 2, 3 4 2 Monica D. Moºescu, Roxana Chiriþã Magdalena Dragu, Alina V. Ungureanu, Vasile Chiriþã Abstract:
More informationCLINICAL STUDY REGARDING THE INFLUENCE OF PROTON PUMP INHIBITORS THERAPY ON THE EVOLUTION OF GASTRIC AND DUODENAL ULCER, ON ELDERLY PATIENTS
FARMACIA, 2011, Vol. 59, 4 573 CLINICAL STUDY REGARDING THE INFLUENCE OF PROTON PUMP INHIBITORS THERAPY ON THE EVOLUTION OF GASTRIC AND DUODENAL ULCER, ON ELDERLY PATIENTS CRISTIAN BĂLĂLĂU 1, FLORIAN POPA
More informationInterferon-gamma Inducible Protein 10 - biomarker for treatment outcome in chronic hepatitis C
Romanian Biotechnological Letters Vol.22, No. x, Copyright 216 University of Bucharest Printed in Romania. All rights reserved ORIGINAL PAPER Interferon-gamma Inducible Protein 1 - biomarker for treatment
More informationTreatment of chronic hepatitis C in HIV co-infected patients
Treatment of chronic hepatitis C in HIV co-infected patients Vicente Soriano Department of Infectious Diseases Hospital Carlos III, Madrid, Spain The most prevalent chronic viral infections in humans HBV
More informationHepatitis C: Ribavirin/Pegylated Interferon combination therapy
Hepatitis C: Ribavirin/Pegylated Interferon Introduction This information sheet is for people who want to know more about the ribavirin/pegylated interferon combination treatment for Hepatitis C (HCV).
More informationArbutus Biopharma Corporation, Burnaby, Canada.
HBcrAg, HBV-RNA Declines in A Phase 2a Study Evaluating the Multi-Dose Activity of ARB-1467 in Positive and Negative Virally Suppressed Patients With Hepatitis B Kosh Agarwal 1, Ed Gane 2, Wendy Cheng
More information19-21 octombrie 2017 Hotel Ramada Parc/Ramada Plaza, București PACHETE DE PROMOVARE
19-21 octombrie 2017 Hotel Ramada Parc/Ramada Plaza, București PACHETE DE PROMOVARE 5 Principalele coordonate ale Congresului Național de Neuropatie Diabetică și Picior Diabetic, cu participare internațională
More informationPERI-INTRAVENTRICULAR HEMORRHAGE IN PRETERM INFANTS: THE IMPORTANCE OF SCREENING BY TRANSFONTANELLAR ULTRASOUND
11 CASE STUDIES PERI-INTRAVENTRICULAR HEMORRHAGE IN PRETERM INFANTS: THE IMPORTANCE OF SCREENING BY TRANSFONTANELLAR ULTRASOUND Mirela Elena Ritivoiu 1, Florin Nicolaie Brezan 1, Cosmina Cristea 2, Ioana
More informationSTUDY ON THE CHRONIC ANTITHROMBOTIC TREATMENT AFTER SURGICAL REVASCULARIZATIONS IN THE PERIPHERAL ARTERIAL DISEASE
492 STUDY ON THE CHRONIC ANTITHROMBOTIC TREATMENT AFTER SURGICAL REVASCULARIZATIONS IN THE PERIPHERAL ARTERIAL DISEASE MARIAN BROASCĂ 1*, DANA ELENA NEDELCU 2 1 Floreasca Emergency Hospital, Calea Floreasca
More informationFARM MIXTURES AND SLOW BREEDING BROILERS
Cercetări Agronomice în Moldova, Anul XXXX, Vol. 1 (129) / 2007 FARM MIXTURES AND SLOW BREEDING BROILERS Doina LEONTE *, C. LEONTE, Valerica MACOVEI University of Agricultural Sciences and Veterinary Medicine
More informationPACHETE DE PROMOVARE
PACHETE DE PROMOVARE Principalele coordonate ale Congresului Național de Neuropatie Diabetică și Picior Diabetic, cu participare internațională Neurodiab 2016 sunt: Speakeri de renume internațional Program
More informationROLE OF IL28B AND ITPA POLYMORPHISMS IN DIFFERENT GENOTYPES OF HCV
ROLE OF IL28B AND ITPA POLYMORPHISMS IN DIFFERENT GENOTYPES OF HCV (Especially HCV-6) WK Seto Clinical Assistant Professor Department of Medicine Queen Mary Hospital The University of Hong Kong HCV GENOTYPES:
More informationSubjects with Elevated CRP Levels and Asymptomatic PAD Prone to Develop Cognitive Impairment
Subjects with Elevated CRP Levels and Asymptomatic PAD Prone to Develop Cognitive Impairment Pavel Dan Nanu 1, Sanda Maria Deme 1, Ramona Maria Chendereş 1 Abstract: The CRP is an independent predictor
More informationDe la eradicarea (individuala) la eliminarea (globala) VHC: Modelare pentru un Plan National de Eliminare in Romania pana in 2030
De la eradicarea (individuala) la eliminarea (globala) VHC: Modelare pentru un Plan National de Eliminare in Romania pana in 2030 Liana Gheorghe Profesor de Gastroenterologie sihepatologie Universitatea
More informationFARMACIA, 2017, Vol. 65, 1
FARMACIA, 2017, Vol. 65, 1 ORIGINAL ARTICLE EVALUATION OF BONE MINERAL DENSITY AND CORRELATIONS WITH INFLAMMATION MARKERS IN ROMANIAN HIV-POSITIVE PATIENTS UNDERGOING COMBINED ANTIRETROVIRAL THERAPY DANIELA
More informationTreatment strategies for recurrent hepatitis C after living donor liver transplantation (from Kyushu University experience)
Korean Association of HBP Surgery President: Dong Wook Choi, MD, PhD, Samsung Medical Center Session : 09:50-10:50, 2 nd /3, Apr 27, 2013 Venue: Lotte Hotel, Jeju Island, Korea Session: Prevention of original
More informationHepatitis C Update. Geri Brown, M.D. Associate Professor Department of Internal Medicine March 24, 2011
Hepatitis C Update Geri Brown, M.D. Associate Professor Department of Internal Medicine March 24, 2011 Outline n Educational Objectives Epidemiology and Natural History of Hepatitis C Current Treatment
More informationReal lifeexperienceonhcv treatment, Simeprevir+Sofosbuvirat 2 University Hospitalsin Galicia.
Real lifeexperienceonhcv treatment, Simeprevir+Sofosbuvirat 2 University Hospitalsin Galicia. Iria Rodríguez Osorio Clinical Virology Group, INIBIC-CHUAC Internal Medicine Service, CHUAC iria.rodriguez.osorio@sergas.es
More informationShort term effects of atorvastatin on leucocytes integrin expression in unstable angina
62 Short term effects of atorvastatin on leucocytes integrin expression in unstable angina Efecte de scurtă durată ale atorvastatinei asupra expresiei integrinelor leucocitare în angina pectorală instabilă
More informationCorrelation between Vitamin D Receptor SNP ApaI and liver fibrosis in HCV patients from Thrace
Correlation between Vitamin D Receptor SNP ApaI and liver fibrosis in HCV patients from Thrace A. Beka 1, T. Mylopoulou 2, V. Papadopoulos 2, I. Karakasiliotis 2, P. Mavromara 1, K. Mimidis 2, S. Veletza
More informationUniversitatea de Medicină şi Farmacie Carol Davila, Bucureşti 2. Institutul Naţional de Diabet, Nutriţie şi Boli Metabolice N.C. Paulescu, Bucureşti
10 PROBLEME DE CERCETARE ASOCIEREA ALANINAMINOTRANSFERAZEI ŞI γ-glutamiltransferazei CU COMPONENTELE SINDROMULUI METABOLIC LA PACIENŢII CU DIABET ZAHARAT TIP 2 NOU DIAGNOSTICAT Relationship of alanin aminotransferase
More informationEFFECT OF FOREARM, HAND AND WRIST EXERCISES ON WRITING SPEED IN HEALTH SCIENCE STUDENTS OF NAGPUR
VOL. 19/ NR 31/ 2013 REVISTA ROMÂNĂ DE KINETOTERAPIE EFFECT OF FOREARM, HAND AND WRIST EXERCISES ON WRITING SPEED IN HEALTH SCIENCE STUDENTS OF NAGPUR EFECTUL EXERCIŢIILOR ANTEBRAŢULUI, PUMNULUI ŞI MÂINII
More informationHVM BIOFLUX Human & Veterinary Medicine International Journal of the Bioflux Society
HVM BIOFLUX Human & Veterinary Medicine International Journal of the Bioflux Society Daily hassles in a population of Romanian adolescents 1 Bogdan Nemeş, 1 Doina Cosman 1 Department of Clinical Psychology,
More informationQué aporta el laboratorio a la terapia del VHC en 2015?
Qué aporta el laboratorio a la terapia del VHC en 2015? Eva Poveda Division of Clinical Virology INIBIC-Complexo Hospitalario Universitario de A Coruña HCV Medicine in 2015 Liver function & fibrosis Molecular
More informationFactori predictivi ai riscului de osteoporoză la pacienţii cu diabet zaharat tip 1
UNIVERSITATEA DE MEDICINĂ ŞI FARMACIE IULIU HAŢIEGANU CLUJ-NAPOCA REZUMATUL TEZEI DE DOCTORAT Factori predictivi ai riscului de osteoporoză la pacienţii cu diabet zaharat tip 1 Doctorand Monica Goia-Socol
More informationHepatitis C Management and Treatment
Hepatitis C Management and Treatment Kaya Süer Near East University Faculty of Medicine Infectious Diseases and Clinical Microbiology 1 Discovery of Hepatitis C Key facts Hepatitis C: the virus can cause
More informationEPIDEMIOLOGY, CLINICAL FEATURES AND OUTCOME OF ACUTE HEPATITIS C IN HIV-POSITIVE PATIENTS: PRESENTATION OF OUR EXPERIENCE
EPIDEMIOLOGY, CLINICAL FEATURES AND OUTCOME OF ACUTE HEPATITIS C IN HIV-POSITIVE PATIENTS: PRESENTATION OF OUR EXPERIENCE E. Angeli, A. Mainini, C. Atzori, G. Gubertini and G. Rizzardini II Dept. Infectious
More informationSpitalul Clinic Judetean de Urgenta str Clinicilor 3-5, , Cluj Napoca (Romania)
Europass Curriculum Vitae Informatii personale Nume, Prenume (Nume anterior casatoriei: Padure ) Adresa Str. C.A.Rosetti, Nr. 16, Cluj Napoca (Romania) Telefon 0040745459080 E-mail(s) munteana2@yahoo.com
More informationVIROLOGY AND MOLECULAR MEDICINE SESSION Bucharest, March 28, 2012 ABERRANT CYTOKINE RECEPTOR SIGNALING DRIVING ACUTE LYMPHOBLASTIC LEUKEMIA
THE PUBLISHING HOUSE MEDICINE OF THE ROMANIAN ACADEMY Review article VIROLOGY AND MOLECULAR MEDICINE SESSION Bucharest, March 28, 2012 SPECIAL CONFERENCES ABSTRACTS ABERRANT CYTOKINE RECEPTOR SIGNALING
More informationA comparison of short-term therapeutic efficacy between infliximab and tacrolimus for moderate to severe ulcerative colitis
A comparison of short-term therapeutic efficacy between infliximab and tacrolimus for moderate to severe ulcerative colitis HIROKAZU YAMAGAMI 1, *, YU NISHIDA 1, YASUAKI NAGAMI 1, SHUHEI HOSOMI 1, TOMOMI
More informationRELATIONSHIP BETWEEN AGGRESSIVE DRIVING, PAIN PERCEPTION AND PERSONALITY TRAITS AT DRIVERS
International Journal of Traffic and Transportation Psychology Volume 3, ISSUE 2 / 2015 www.ijttp.ro RELATIONSHIP BETWEEN AGGRESSIVE DRIVING, PAIN PERCEPTION AND PERSONALITY TRAITS AT DRIVERS CRISTINA
More informationA Study to detect the seasonal effect of chickenpox in Bangladesh
STATISTICA ÎN ALTE ŢĂRI: A Study to detect the seasonal effect of chickenpox in M. O. Ullah, M.Sc. in Biostatistics, Assistant professor M. J. Uddin, M.Sc. in Statistics, Assistant professor Dr. M. Rahman,
More informationSimeprevir + PEG + RBV in Treatment-Naïve Genotype 1 QUEST-1 Trial
Phase 3 Treatment Naïve Simeprevir + in Treatment-Naïve Genotype 1 QUEST-1 Trial Jacobson IM, et al. Lancet. 2014;384:403-13. Simeprevir + PEG + Ribavirin for Treatment-Naïve HCV GT1 QUEST-1 Trial QUEST-1
More informationC- REACTIVE PROTEIN IN RECENTLY OPERATED PERIPHERAL ARTERIAL DISEASE PATIENTS AND TREATED WITH ELECTROACUPUNCTURE POSTOPERATIVELY
ORIGINAL ARTICLES C- REACTIVE PROTEIN IN RECENTLY OPERATED PERIPHERAL ARTERIAL DISEASE PATIENTS AND TREATED WITH ELECTROACUPUNCTURE POSTOPERATIVELY Marius E. Sintean 1, Petru M Deutsch 1, Alina Lupu 1,
More informationAcidul Hialuronic si HEPASCORE diagnostic inovativ al fibrozei hepatice
Acidul ialuronic si EPASCRE diagnostic inovativ al fibrozei hepatice Proton Impex 2000 Topics Ce este Acidul ialuronic (A)? Structura chimica Caracteristici medicale De ce e utila masurarea A? Semnificatia
More informationUrinary Leukotriene Level in Children with Asthma
: 20-25 Copyright Celsius Original Paper Urinary Leukotriene Level in Children with Asthma Eugenia Buzoianu 1,2, Mariana Moiceanu 2, Oana Virban 2, Varvara Toma 1,2, Felicia Cora 1,2, Aurora Craiciu 2,
More informationFunctia Integrativa a Creierului
Functia Integrativa a Creierului The evolution and classification of primates. Tarsiers are generally considered to be prosimians, but they are related more closely to anthropoids, so they are recognized
More informationCOMPARATIVE ASSESSMENT OF POLLUTION LEVEL IN TWO INDUSTRIAL AREAS USING BIOINDICATORS
Contribuţii Botanice, XXXIX, 2004 Grădina Botanică Alexandru Borza Cluj-Napoca Katalin BARTÓK 1, Ana-Maria RUSU 2 1 Universitatea Babeş-Bolyai, Facultatea de Biologie şi Geologie, str. Republicii, nr.
More informationClinical Cases Hepatitis C Naïve Patients. Rafael Esteban Liver Unit. Hospital General Universitari Vall Hebron. Barcelona.
Clinical Cases Hepatitis C Naïve Patients Rafael Esteban Liver Unit. Hospital General Universitari Vall Hebron. Barcelona. Case study 1 27 year old woman, Diagnosed with Chronic Hepatitis C 3 years ago
More informationYou have been diagnosed with chronic hepatitis C. I I
You have been diagnosed with chronic hepatitis C I I Prevalence Estimated 130-210 million people currently infected with hepatitis C. Estimated 50,000 people in New Zealand infected with chronic hepatitis
More informationTreatment Options in HCV Relapsers and Nonresponders. Raymond T. Chung, M.D.
Session IV Treatment Options in HCV Relapsers and Nonresponders Raymond T. Chung, M.D. Director of Hepatology, Massachusetts General Hospital, Associate Professor of Medicine, Harvard Medical School, Boston,
More informationTHE INFLUENCE OF ENERGY DRINKS ON RACTIVITY TO MULTIPLE STIMULY-A PILOT STUDY
THE INFLUENCE OF ENERGY DRINKS ON RACTIVITY TO MULTIPLE STIMULY-A PILOT STUDY DAISY MONALISA GRANSCA a, MIHAI ANITEI b a,b University of Bucharest, Department of Psychology Abstract The experimental study
More informationContemporary use of digoxin in clinical practice Carmen Ginghina 1,2, Monica Chivulescu 1, Andreea Calin 1,2, Gabriela Raileanu 1, Eduard Apetrei 1,2
Romanian Journal of Cardiology ORIGINAL ARTICLE Carmen Ginghina 1,2, Monica Chivulescu 1, Andreea Calin 1,2, Gabriela Raileanu 1, Eduard Apetrei 1,2 Abstract & aims: Although mortality is the most important
More informationNEW THERAPEUTICAL ALTERNATIVES AND OUTCOME IN MILD COGNITIVE IMPAIRMENT
ORIGINAL ARTICLES NEW THERAPEUTICAL ALTERNATIVES AND OUTCOME IN MILD COGNITIVE IMPAIRMENT 1 2 Camelia Mila, Delia M. Podea Abstract: Background: Mild cognitive impairment (MCI) is an etiological heterogeneous
More informationINVESTIGATION OF EFFECTIVNESS OF CONTROLED DIPHRAGMATIC BREATHING ON PULMONARY FUNCTION & SIX MINUTE WALK DISTANCE IN STABLE COPD PATIENTS
INVESTIGATION OF EFFECTIVNESS OF CONTROLED DIPHRAGMATIC BREATHING ON PULMONARY FUNCTION & SIX MINUTE WALK DISTANCE IN STABLE COPD PATIENTS INVESTIGAREA EFICIENŢEI RESPIRAŢIEI DIAFRAGMATICE CONTROLATE ASUPRA
More informationthe future and the past are the leaf s two faces
The tree Prof. Dr. Mircea Diculescu Gastroenterology and Hepatology Center Fundeni Bucharest the future and the past are the leaf s two faces 1 Forsees the Beginning who is able to learn The Roots 2 The
More information