FORMULATION AND EVALUATION OF TASTE MASKED FAST DISSOLVING TABLETS OF TENOFOVIR

Size: px
Start display at page:

Download "FORMULATION AND EVALUATION OF TASTE MASKED FAST DISSOLVING TABLETS OF TENOFOVIR"

Transcription

1 Available online at International Journal of Trends in Pharmacy and Life Sciences Vol. 2, Issue: 3, 2016: FORMULATION AND EVALUATION OF TASTE MASKED FAST DISSOLVING TABLETS OF TENOFOVIR S.Ibrahim Saheb*,S Habibulla, T. Shahanaz Begum,V. Lakshmana Murthy, E. Shabarish, E.Satheesh Kumar Department of Pharmaceutics, Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh. ABSTRACT Tenofovir disoproxil fumarate (a prodrug of Tenofovir) In vivo Tenofovir disoproxil fumarate is converted to Tenofovir, an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5'- monophosphate. Tenofovir exhibits activity against HIV-1 reverse transcriptase. Tenofovir is water soluble drug having poor bioavailabilty and bitter taste. Thus the Purpose of this study is to formulate and evaluate taste masked fast dissolving tablets of Tenofovir. Drug and excipient compatibility studied by using FTIR studies showed that there are no interactions. These tablets of Tenofovir were prepared by using β- cyclodextrin as taste masking agent. Seven formulations (F1-F7) were prepared by varing the concentrations of super disintegrants such as cross caramellose sodium, crospovidine and sodium starch glycolate. Tablets were prepared by direct compression method. The prepared tablets were evaluated for all physical parameters, disintegration time, Invitro dispersion, weight variation, hardness, and friability and invitro dissolution studies. An Invitro dissolution study shows that formulation F6 containing sodium starch glycollate as super disintegrant showed 98% drug release when compared to the other formulations. Keywords: Tenofovir disoproxil fumarate, Taste masking, β- cyclodextrin, sodium starch glycollate, cross caramellose sodium and crospovidine *Corresponding Author: S.Ibrahim Saheb, Department of Pharmaceutics, Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh. Received: 04/03/2016 Revised: 26/03/2016 Accepted: 29/03/2016 INTRODUCTION Fast dissolving tablets (FDT) disintegrates and dissolves rapidly in saliva without need of drinking water. The FDT usually dissolve in the oral cavity in about 10 seconds to 3 minutes. Faster the drug goes into solution, the quicker absorption and onset of clinical effect. These tablets are not only indicated for the people who have swallowing difficulties, but also ideal for active people [1-3]. Tenofovir [4] which is the prodrug of Tenofovir disoproxil fumarete is a white to off-white crystalline powder with the IUPAC name ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2- yl]oxy}methyl)phosphonic acid, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people[5]. Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

2 MATERIALS AND METHODS Table 1: Materials used in the Formulation S.No. Drug/Exciepents Source 1 Tenofovir disoproxil fumarete Gift sample from CIPLA,Bengaluru 2 β-cyclodextrins [6] Baris pharma Pvt.Ltd,Hyderabad 3 Lactose S.D. Fine chemicals Pvt.Ltd,Mumbai 4 Crospovidone Global merchants,vadgadi,mumbai 5 Croscarmellose cellose Hiranya cellulose products,gandhi nagar,hyderabad 6 Sodium starch glycolate S.V. Enterprisers,Mumbai 7 Aspartame A.B. Enterprisers,Shradanand buildings, Mumbai 8 Aerosil S.D. Fine chemicals Pvt.Ltd,Mumbai 9 Talc S.D. Fine chemicals Pvt.Ltd,Mumbai FORMULATION DEVELOPMENT All ingredients were selected for formulation based on preformulation studies and literature review Brief Manufacturing Procedure of Preperation of tablets by direct compression method Weigh all the ingredients separately API and other excipients are passed through the 60 # sieve and blended for 15 minutes Compress the blend into tablet by 11 mm concave punches.bb tooling on eight station rotary tablet compression machine. Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

3 Table 2: Formulation design of the fast dissolving tablets Ingredietns (mg) F-1 F-2 F-3 F-4 F-5 F-6 F-7 Tenofovir β-cyclodextrin Lactose Crospovidine Corscaramellose sodium Sodium starch glycolate Total wt. Of Tablet(mg) Table 3: Instruments / Equipment used in the Formulation and Evaluation S.No. Name of the Instrument / Equipment Make 1 Rotary tablet compression machine model-ii, Rinek 2 Friabilator USP EF-2,Friabilator,Electro Lab,Mumbai 3 Hardness tester Aspertame Aerosil Talc Pfizer,Servewell instruments and equipments pvt.ltd.,banglore 4 Digital vernier scale RK Industries,Mumbai 5 Bulk Density apparatus DBK Instruments,Mumbai 6 Mettler Balance Model-AE-160,Mettler, Switzerland. 7 Digital ph meter 7007,Digisun Electronics,Hyderabad 8 Disintegration tester USP Electro Lab 9 FT-IR Model-FTIR-Bruker 10 Dissolution apparatus DBK Instruments,Mumbai 11 UV spectrophotometer Model-UV-1601, Shimadzu. 12 Hot air oven Parekh Scientifics[INDIA],Mumbai Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

4 PREFORMULATION STUDIES [1-3] Drug excipient compatibility [FTIR studies] Compatability of the drug with excipients (Beta Cyclodextrin, Lactose Crospovidone, SSG, Aspartame, aerosol and Talc) used to produce FDT was established by IR spectral analysis. IR spectral analysis of pure drug, with the excipients was carried out. This study was carried out to detect any changes on chemical constitution of the drug after combining it with the excipient. The drug and excipients were mixed in a ratio of 1:1 placed in a petri dish and kept in a hot air oven at 45 0 C RH 75% for a period of 15 days. The samples were scanned over wave number ranges of cm -1. Angle of repose The angle of repose was measured by passing the prepared granules through a sintered glass funnel of internal diameter 27mm on the horizontal surface. The height (h) of the heap formed was measured with a cathetometer and the radius(r) of the cone base was also determined. The angle of repose (θ) was calculated from equation [1-3] Angle of repose (θ) =Tan -1 h/r Bulk density The term bulk density referes to a measure used to describe a packing of particles. It is expressed in gm/ml and was determined using a balance and measuring cylinder. Initially the weight of the measuring cylinder was tarred, 5gm pre sieved (40#) bulk drug were poured into the measuring cylinder using a funnel and weighed(m).then volume of the powder (Vb) was taken.bulk density of the granules was calculated using the following formula[1-3] Bulk density = M/Vb Tapped density Blend was tapped for a fixed number of taps. The minimum volume (Vt) occupied in the cylinder and the weight (M) of the blend was measured. The tapped density was calculated using following formula. Tapped density = M/ Vt Compressibility (Carr s) Index An accurate weight of granules was poured into a volumetric cylinder to occupy a volume (V 0 ) and then subjected to a standard tapping procedure onto a solid surface until a constant volume was achieved (Vf). The Carr s index was calculated using equation Compressiblity index = V 0 V f X V 0 Hausner s ratio[1-3] Hausner s ratio is an indirect index of ease of powder flow. It is calculated by the following formula, Hausner s ratio = tapped density / bulk density Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

5 EVALUATION OF TABLETS Weight variation: Twenty tablets were selected from formulated tablets at random and the average weight was calculated, individual tablet weights were compared with the average weight. Not more than two individual weights deviate from the average weight by more than the percentage. [1-3] Average weight -Tablet weight % Deviation = X Average weight Hardness: The tablet hardness, which is the force required to break a tablet in a diametric compression force. Pfizer hardness tester was used for the determination of the hardness which applies force to the tablet diametrically with the help of an inbuilt spring. For each formulation 6 tablets were determined. It is expressed in kg/cm 2 [1-3]. Friability: Friability of the tablet was checked by using Roche friabilator. This device Subjects a number of tablets to the combined effect of the abrasion and shock by utilizing a plastic chamber that revolves at 25 rpm dropping at a distance of 6 inches with each revolution. Preweighed samples of tablets were placed in the friabilator, which was then operated for revolutions. Tablets were dedusted using a soft muslin cloth and reweighed [1-3]. The friability (f) is given by the formula: f= (1-W 0 /W) W 0 is weight of the tablet before test W is weight of the tablet after test. Thickness: Thickness of the tablets was determined using digital Vernier calipers. 5 tablets from each formulation and average were calculated [1-3]. In-Vitro disintegration time: [7,8] In-vitro disintegration time of 6 tablets from each formulation was determined by using digital tablet disintegration apparatus. In-vitro disintegration test was carried out at 37 2 o C in 900 ml of distilled water. Six tablets were taken and one tablet was introduced in each tube, disc was placed and basket rack was positioned in 1 liter beaker containing water 37 2 o C and apparatus operated for 6 min and the disintegration time in seconds was noted [1-3]. In-vitro- dispersion test: Tablet was added to 6 ml of phosphate buffer solution, ph 6.8 at o C time required for the complete dispersion of a tablet was determined. From each batch average of 3 tablets were selected randomly In-vitro dispersion time was Performed [1-3]. Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

6 Wetting time: This is carried out as a measure of hydrophilicity of tablets. Wetting time is a length of time required to wet the tablet. A piece of tissue paper (12x10.75) was folded twice was placed in the small petri dish (I.D = 6.5 cm) containing 6 ml of simulated saliva ph, a tablet was put on the paper and the time for complete wetting was measured. Three trials for each batch were performed and standard deviation was also determined. Water absorption ratio: Water absorption ratio, which is important criteria for understanding the capacity of disintegrants to swell in the presence of little amount of water. Weight of the tablet after and before test was taken. Water absorption ratio (R) is calculated using following formulae [1-3]. W a R = W a -W b W b X = Weights of the tablets after water absorption test. W b = Weights of the tablets before water absorption test. Dissolution studies: [7-8] Dissolution rate was studied by using USP type II paddle apparatus at 50 rpm. Phosphate Buffer of ph 6.8, 900 ml used as dissolution media. Temperature was maintained at 37 0 C C. Aliquots of dissolution media was withdrawn at specific time intervals and it was filtered. Same amount of the fresh dissolution media was replaced. The filtered solution was determined for drug content spectrometrically at 260 nm. Dissolution rate studies were carried for all designed formulations [1-3]. RESULTS AND DISCUSSION Table 4: Observation for Physical Incompatibility S. No Name of the Excipient Category Ratio API: Excipient At 40 0 C/ 75%RH (30 days) 1. Tenofovir-API Drug 1 NCC 2. API+β-Cyclodextrin Complexing agent 1 : 1 NCC 3. API+ Lactose Diluent 1 : 1 NCC 4. API+ Crospovidone Disintegrent 1 : 1 NCC 5. API+Croscarmellose sodium Disintegrent 1 : 1 NCC API+ Sodium starch glycolate API+ Saccharin Disintegrent 1 : 1 NCC Sweetener 1 : 1 NCC 8. API+ Aerosil Glidant 1 : 1 NCC 9. API +Talc Lubricant 1 : 1 NCC Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

7 Transmittance [%] RESEARCH ARTICLE e-issn: Wavenumber cm D:\IR DATA\.1039 TEMOLOVIR SOLID 1/6/2016 Page 1/1 Fig.1: FTIR spectra of pure drug Tenofovir Wavenumber cm D:\IR DATA\.1035 T LACTOSE SOLID 1/6/2016 Page 1/1 Fig.2: FTIR spectra of pure drug Tenofovir+ Lactose Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

8 Transmittance [%] Transmittance [%] RESEARCH ARTICLE e-issn: Wavenumber cm-1 D:\IR DATA\.1037 T BCYCLODELTRIN SOLID 1/6/2016 Page 1/1 Fig.3: FTIR spectra of Tenofovir + betacyclodextrin Wavenumber cm-1 D:\IR DATA\.1036 T CROSPOVIDONE SOLID 1/6/2016 Page 1/1 Fig. 4: FTIR spectra of Tenofovir + Crospovidone Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

9 Transmittance [%] RESEARCH ARTICLE e-issn: Wavenumber cm D:\IR DATA\.1033 T CROSEARMELLOSE SOLID 1/6/2016 Page 1/1 Fig.5: FTIR spectra of Tenofovir + Croscarmellose sodium Wavenumber cm D:\IR DATA\.1040 T SODIUM STARCH SLYCOLYTE SOLID 1/6/2016 Page 1/1 Fig.6 : FT-IR spectra of Tenofovir + Sodium starch glycolate Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

10 Transmittance [%] Transmittance [%] RESEARCH ARTICLE e-issn: Wavenumber cm-1 D:\IR DATA\.1038 T AEROSIL SOLID 1/6/2016 Page 1/1 Fig. 7: FT-IR spectra of Tenofovir + Aerosil Wavenumber cm D:\IR DATA\.1041 T TALC SOLID 1/6/2016 Page 1/1 Fig. 8: FT-IR spectra of Tenofovir + Talc Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

11 Absorbance(nm) RESEARCH ARTICLE e-issn: Table 5: Calibration Curve of Tenofovir Conc.( g/ml) Absorbance at 260 (nm)x Calibration curve of Tenofovir concentration(μg/ml) Fig.9: Calibration Curve of Tenofovir Table 6: In-vitro - disintegration test S.No. Formulation No Disintegration Time(sec) 1 F-1 206±2 2 F-2 237±1 3 F-3 228±3 4 F-4 334±2 5 F-5 289±3 6 F-6 302±1 7 F-7 340±1 Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

12 SECONDS 80 SECONDS SECONDS 160 SECONDS SECONDS 302 SECONDS Fig. No. 10: Process of disintegration of FDTS Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

13 Table 7: Evaluation of the blend Formulation Code Bulk density (g/cm 3 ) Tapped density (g/ cm 3 ) Hausner s Ratio Compressibility Index % Angle of Repose(θ) F ± ± ± ± ±0.01 F ± ± ± ± ±0.03 F ± ± ± ± ±0.01 F ± ± ± ± ±0.03 F ± ± ± ± ±0.01 F ± ± ± ± ±0.02 F ± ± ± ± ±0.01 The blends were evaluated for the tapped density, bulk density, % compressibility and angle of repose. The result reveals that Compressibility was in the range of 13.7 to 38.0 which indicates good to fair Compressibility of the powdered material. Angle of repose ranging from to shows fair flow ability. Hausner s ratio was found in the range of , which indicates good flow properties as reported in the table. Table 8: Dissolution drug release data of formulations F1-F4 S. No Time (mins) % Drug Release F1 F2 F3 F ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±1.5.87± ± ±1 Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

14 % Drug Release % drug Release RESEARCH ARTICLE e-issn: F1-F Time(mins) Fig.11: Dissolution drug release data of formulations F1-F4 Table 9: Dissolution drug release data of formulations F5-F7 S. No Time (mins) % Drug Release F5 F6 F ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±1 120 F5-F Time(mins) Fig.12: Dissolution drug release data of formulations F5-F7 Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

15 SUMMARY The objective of the study was to formulate and evaluate the fast dissolving tablets of the Tenofovir. The study results are summarized below. The Preformulation studies of the Tenofovir were performed and drug excipients compatibility studies showed that there was no interaction between the drug and excipients chosen for the formulation as evident from FTIR. Tenofovir is a good water solubility drug but possess poor bioavailability hence its bioavailability was enhanced by complexation with Beta Cyclodextrin(1:1), for fast onset of the clinical action and to have better bioavailability. Tenofovir is a drug with slightly bitter taste in nature. So bitter taste of the drug is almost being reduced by using the sensory approaches like by the use of the sweeteners (aspartame). Crosscarmellose sodium and Crospovidone showed good compressibility, good compatibility, flowability & stability. Tablets formulated by using super disintegrants crospovidone and crosscarmellose sodium showed minimum In-vitro disintegration, dispersing time and wetting time. Crosprovidone and Sodium starch glucolate has good water absorption ratio. Dissolution studies indicated that 69.34% of the drug was released from F-1,90.01%drug release from F-2,93%drug release from F-3, %drug release from F-4, %drug release from F-5 and 98% of drug was released from the formulation F-6 with in 15 min. F-3 and F-6 formulations have sown no significant difference in their physical and chemical integrity. CONCLUSION It concluded that beta cyclodextrins were useful for enhancing the solubility of the poorly soluble drugs. Super disintegrants were helpful in formulation of the Fast dissolving tablets. Croscarmellose sodium and sodium starch glycolate are suitable for the formulation of the FDTs of among the three disintegrants used in the formulations. References 1. Reddy LH, Bijaya Ghosh, Rajneesh. A review of literature: Fast dissolving drug delivery system. Ind J Pharma Sci. 2002: 64 (4); Shirwaikar A.A and Ramesh A. Fast disintegrating tablets of Atenolol by dry granulation method. Ind J Pharma Sci. 2004: 66 (4); Vasavi Reddy D, Srilatha U, Rama Krishna M, and Srinivas Reddy Devireddy, Formulation And Evaluation Of Emtricitabine AndTenofovir Disoproxil Fumarate Film Coated Tablets, International Journal Of Research In Pharmacy And Chemistry. IJRPC. 2015: 5(1); browsed on 08 th November Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

16 5. The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years MR Nelson, C Katlama, JS Montaner, DA Cooper - Aids, journals.lww.com Shah.FIP/AAPS Guidelines for Dissolution/ Invitro Release Testing of Novel/Special Dosage Forms. Dissolution Technologies. May James Klancke. Dissolution Testing of Orally Disintegrating Tablets. Dissolution Technologies. May Ibrahim Saheb S et al. Int J Trends in Pharm & Life Sci. 2016: 2(3);

Formulation and evaluation of oro-dispersible tablets of lafutidine

Formulation and evaluation of oro-dispersible tablets of lafutidine Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (5):226-235 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CHEMICAL SCIENCES

INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CHEMICAL SCIENCES Research Article Formulation, Development and Evaluation of Fast Dissolving Tablet of Salbutamol Sulphate by Using Superdisintegrants of Various Concentrations Santosh K 1 *, Meenakshi B 2 and Jyoti M

More information

Available online through ISSN

Available online through  ISSN Research Article Available online through www.ijrap.net ISSN 2229-3566 FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLETS OF METOPROLOL TARTRATE BY DIRECT COMPRESSION USING SUPER DISINTEGRANTS A. Senthil*

More information

EFFECT OF SUPERDISINTEGRANTS ON RELEASE OF DOMPERIDONE FROM FAST DISSOLVING TABLETS

EFFECT OF SUPERDISINTEGRANTS ON RELEASE OF DOMPERIDONE FROM FAST DISSOLVING TABLETS ISSN: 22-7346 B. Sujatha et al. / JGTPS/ 5(3)-(2014) 1973 1978 (Research Article) Journal of Global Trends in Pharmaceutical Sciences Journal home page: www.jgtps.com EFFECT OF SUPERDISINTEGRANTS ON RELEASE

More information

FORMULATIO A D EVALUATIO OF ORO DISPERSIBLE TABLETS OF CLO AZEPAM BY DIRECT COMPRESSIO METHOD

FORMULATIO A D EVALUATIO OF ORO DISPERSIBLE TABLETS OF CLO AZEPAM BY DIRECT COMPRESSIO METHOD FORMULATIO A D EVALUATIO OF ORO DISPERSIBLE TABLETS OF CLO AZEPAM BY DIRECT COMPRESSIO METHOD THAKKAR HARDIK R*, A.SENTHIL, RAVIKUMAR, V.B. NARAYANA SWAMY Karavali College of Pharmacy, Mangalore-575028,

More information

FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES

FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES Research Article Deshmukh ND,, 2012; Volume 1(5): 364-378 ISSN: 2277-8713 FORMULATION AND EVALUATION OF BISOPROLOL FUMARATE FAST DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES *N. D. DESHMUKH, R. R.

More information

Formulation and evaluation of immediate release salbutamol sulphate

Formulation and evaluation of immediate release salbutamol sulphate 5 Formulation, optimization and evaluation of immediate release layer of salbutamol sulphate Salbutamol is moderately selective beta (2)-receptor agonist similar in structure to terbutaline and widely

More information

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY ISSN Research Article

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY  ISSN Research Article INTERNATIONAL RESEARCH JOURNAL OF PHARMACY www.irjponline.com ISSN 2230 8407 Research Article FORMULATION AND EVALUATION OF IMMEDIATE RELEASE VENLAFAXINE HCL TABLETS: COMPARATIVE STUDY OF SUPER DISINTEGRANT

More information

Design and In-vitro Evaluation of Silymarin Bilayer Tablets

Design and In-vitro Evaluation of Silymarin Bilayer Tablets CODEN (USA)-IJPRUR, e-issn: 2348-6465 International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Original Article Design and In-vitro Evaluation of Silymarin

More information

Pharmacologyonline 2: (2011) ewsletter Mehul et al. FORMULATIO A D EVALUATIO OF ORODISPERSIBLE TABLETS OF PHE IRAMI E MALEATE

Pharmacologyonline 2: (2011) ewsletter Mehul et al. FORMULATIO A D EVALUATIO OF ORODISPERSIBLE TABLETS OF PHE IRAMI E MALEATE FORMULATIO A D EVALUATIO OF ORODISPERSIBLE TABLETS OF PHE IRAMI E MALEATE DAVE MEHUL *, A.SENTHIL, THAKKAR HARDIK R, RAVIKUMAR, LAD TEJAS Karavali College of Pharmacy, Mangalore-575028, Karnataka, India.

More information

FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING AGENTS

FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING AGENTS Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Suppl 1, 2012 Research Article FORMULATION AND EVALUATION OF CEFIXIME TRIHYDRATE ORAL DISINTEGRATING

More information

Formulation and evaluation of sublingual tablets of lisinopril

Formulation and evaluation of sublingual tablets of lisinopril Journal of GROVER Scientific & Industrial AGARWAL: Research FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF LISINOPRIL Vol. 71, June 2012, pp. 413-417 413 Formulation and evaluation of sublingual tablets

More information

Adimoolam Senthil et al. IRJP 2 (1)

Adimoolam Senthil et al. IRJP 2 (1) INTERNATIONAL RESEARCH JOURNAL OF PHARMACY ISSN 2230 8407 Available online http://www.irjponline.com Research Article DEVELOPMENT AND EVALUATION OF ORALLY DISINTEGRATING TABLETS OF METOPROLOL TARTRATE

More information

Formulation and evaluation of oral dispersible tablets of aripiprazole

Formulation and evaluation of oral dispersible tablets of aripiprazole IJPAR Vol.6 Issue 2 April - June -17 Journal Home page: ISSN:23-2831 Research article Open Access Formulation and evaluation of oral dispersible tablets of aripiprazole A.Madhusudhan Reddy*, P.Srinivasababu,

More information

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium Available online on www.ijddt.com International Journal of Drug Delivery Technology 214; (3); 98-13 Research Article ISSN: 97 441 Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast

More information

Optimization of Atenolol Core Tablet CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS

Optimization of Atenolol Core Tablet CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS CHAPTER 5: OPTIMIZATION OF FORMULATION OF ATENOLOL CORE TABLETS 5.1. AIM OF THE STUDY The pulsatile type press coated colon targeted atenolol tablet release drug after 6 hr lag time. The compression coated

More information

Formulation and Evaluation

Formulation and Evaluation Chapter-5 Formulation and Evaluation 5.1 OBJECTIVE After successful taste masking and solubility enhancement of drugs in preliminary studies, by using Mannitol Solid Dispersion, next step includes the

More information

Adimoolam S et al. IRJP 1 (1)

Adimoolam S et al. IRJP 1 (1) INTERNATIONAL RESEARCH JOURNAL OF PHARMACY Available online http://www.irjponline.com Research Article FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF FLUNARIZINE DIHYDROCHLORIDE BY USING SUPER

More information

Formulation and Evaluation of Glicazide Mouth Dissolving Tablets

Formulation and Evaluation of Glicazide Mouth Dissolving Tablets Research Article Vishakha S. Hastak*, Yogyata S. Pathare, Kiran C. Mahajan Department of Pharmaceutics, Shree Chanakya Education Society's Indira college of Pharmacy, Tathawade, Pune, Maharashtra, India.

More information

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD Int. J. Chem. Sci.: 6(3), 2008, 1270-1275 FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD K. P. R. CHOWDARY, P. TRIPURA SUNDARI and K. SURYA

More information

Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets

Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets Pharmaceutics Formulation Development, Evaluation and Comparative Study of Effects of Super Disintegrants in Cefixime Oral Disintegrating Tablets Remya KS, Beena P, Bijesh PV, Sheeba A Nazareth College

More information

Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online)

Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online) Design and development of Metformin hydrochloride Tried sustained release tablets Venkateswara Rao T 1 *, Bhadramma N 1, Raghukiran CVS 2 and Madubabu K 3 Bapatla College of Pharmacy, Bapatla, Guntur-522101

More information

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS Int. J. Chem. Sci.: 7(4), 2009, 2555-2560 FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS HINDUSTAN ABDUL AHAD *, B. PRADEEP KUMAR, C.

More information

FORMULATION DEVELOPMENT AND EVALUATION OF COLON TARGETED DOSAGE FORM OF IBUPROFEN

FORMULATION DEVELOPMENT AND EVALUATION OF COLON TARGETED DOSAGE FORM OF IBUPROFEN FORMULATION DEVELOPMENT AND EVALUATION OF COLON TARGETED DOSAGE FORM OF IBUPROFEN Pranjal Kumar Singh*, Sanjoo Kumar, T.S.Easwari, V.K.Shukla, Guru Sharan Department of Pharmaceutics, IIMT College of Medical

More information

Formulation and Evaluation of Taste Masked Oro-dispersible Tablets of an Anti-HIV Drug

Formulation and Evaluation of Taste Masked Oro-dispersible Tablets of an Anti-HIV Drug Int. J. Pharm. Sci. Rev. Res., 5(), July August 08; Article No., Pages: 78 ISSN 097 044X Research Article Formulation and Evaluation of Taste Masked Orodispersible Tablets of an AntiHIV Drug Arifa Begum.

More information

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS Int. J. Chem. Sci.: 8(1), 2010, 405-414 STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS V. L. NARASAIAH, T. KARTHIK KUMAR, D. SRINIVAS, K. SOWMYA, P. L. PRAVALLIKA and Sk. Md. MOBEEN

More information

Received on: Accepted on:

Received on: Accepted on: ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com FORMULATION, EVALUATION AND OPTIMIZATION OF ORODISPERSIBLE TABLET CONTAINING ANTI-EMETIC DRUG Imran AM* 1, Sudhakar

More information

FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN

FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN Ms. Jyoti Rathore 1*, Mr. Hitesh Kumar Parmar 1 Ujjain Institute of Pharmaceutical Sciences, Ujjain. Email- hkparmar7@rediffmail.com ABSTRACT

More information

B. Jayakar et. al. FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF CELECOXIB R. Margret Chandira, Shyam Sharma, Debjit Bhowmik, B.

B. Jayakar et. al. FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLET OF CELECOXIB R. Margret Chandira, Shyam Sharma, Debjit Bhowmik, B. Page117 Online Available at www.thepharmaresearch.info THE PHARMA RESEARCH, A JOURNAL The Pharma Research (T. Ph. Res.), (2010), 4; 117-122. Published on- 15 Dec 2010 Copyright 2009 by Sudarshan Publication

More information

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011 ISSN: 223-7346 Research Article Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp -394-43, Oct -Dec 211 FORMULATION AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE

More information

INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES

INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES International Journal of Institutional Pharmacy and Life Sciences 6(2): March-April 2016 INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES Pharmaceutical Sciences Research Article!!! Received:

More information

Formulation and Development of Sustained Release Tablets of Valsartan Sodium

Formulation and Development of Sustained Release Tablets of Valsartan Sodium INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article Formulation and Development of Sustained Release Tablets of Valsartan Sodium G. Sandeep * and A. Navya Department of

More information

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012 STUDIES ON EFFECT OF SUPERDISINTEGRANTS ON ETORICOXIB TABLET FORMULATIONS Chowdary K. P. R 1, Venugopal. K *2 1 College of Pharmaceutical Sciences, Andhra University, Vishakapattanam. 2 * Nirmala college

More information

Available Online through

Available Online through ISSN: 0975-766X Available Online through Research Article www.ijptonline.com FORMULATION DESIGN AND OPTIMIZATION OF MOUTH DISSOLVE TABLETS OF GLIPIZIDE R.Shireesh Kiran 1*, B.Chander Shekar 1, Sharadha

More information

Journal of Chemical and Pharmaceutical Research

Journal of Chemical and Pharmaceutical Research Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research J. Chem. Pharm. Res., 2010, 2(5):534-540 ISSN No: 0975-7384 CODEN(USA): JCPRC5 Formulation and evaluation of Valsartan film

More information

Pavan K et al IJARPB: 2013, 3(2), ISSN: Available online on Research Article

Pavan K et al IJARPB: 2013, 3(2), ISSN: Available online on  Research Article Available online on www.ijarpb.com Research Article Received on 15/01/2013; Revised on 23/01/2013; Accepted on 27/01/2013; Fast Dissolving Tablets Of Pioglitazone Hydrochloride By Use Of Various Superdisintegrants

More information

M.Vijaya Laxmi et al., Asian Journal of Pharmaceutical Technology & Innovation, 03 (10); 2015; Research Article

M.Vijaya Laxmi et al., Asian Journal of Pharmaceutical Technology & Innovation, 03 (10); 2015; Research Article Asian Journal of Pharmaceutical Technology & Innovation ISSN: 2347-8810 Research Article Received on: 18-12-2014 Accepted on: 31-12-2014 Published on: 15-02-2015 Formulation and Evaluation of Rizatriptan

More information

Formulation and evaluation of mouth dissolving tablets containing losartan potassium

Formulation and evaluation of mouth dissolving tablets containing losartan potassium Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (17):115-123 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

Formulation and evaluation of intraorally fast dissolving tablet of olmesartan medoxomil

Formulation and evaluation of intraorally fast dissolving tablet of olmesartan medoxomil Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2013, 5 (1):232-237 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine

Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine Mayur V. Chinchore*, Sanjay P. Aher, Chetan P. Mahajan, Ghanshyam J. Yadav, Avish D. Maru Department of Pharmaceutics,

More information

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Volume: 2: Issue-3: July-Sept -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Ajaykumar Patil*, Ashish Pohane, Ramya Darbar, Sharanya Koutika, Alekhya

More information

Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with other Superdisintegrants

Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with other Superdisintegrants International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol. 3, No.3, pp 1119-1124, July-Sept 2011 Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with

More information

Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting

Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting Biresh Kumar Sarkar* 1, Devananda Jain 1, Mamta Parwal 2 1. Bhagwant University, Dept.of Pharmaceutical Tech and Sciences,

More information

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Research Journal of Pharmaceutical, Biological and Chemical Sciences Research Journal of Pharmaceutical, Biological and Chemical Sciences Formulation And Invitro Evaluation Of Sustained Release Matrix Tablets Of Ibuprofen S Shanmugam, T Vetrichelvan and P Niranjan* Adhiparasakthi

More information

Formulation and evaluation of fast dissolving tablet of aceclofenac

Formulation and evaluation of fast dissolving tablet of aceclofenac International Journal of Drug Delivery 2 (2010) 93-97 http://www.arjournals.org/ijdd.html Research article ISSN: 0975-0215 Formulation and evaluation of fast dissolving tablet of aceclofenac Sudhir Bhardwaj

More information

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS Int. J. Chem. Sci.: 10(4), 2012, 1934-1942 ISSN 0972-768X www.sadgurupublications.com STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS K. VENUGOPAL * and K. P. R. CHOWDARY a Nirmala College

More information

International Journal of Medicine and Pharmaceutical Research. International Journal of Medicine and Pharmaceutical Research

International Journal of Medicine and Pharmaceutical Research. International Journal of Medicine and Pharmaceutical Research B.V. Ramana, IJMPR, 2016, 4(5): 252-261 CODEN (USA): IJMPMW ISSN: 2321-2624 International Journal of Medicine and Pharmaceutical Research Journal Home Page: www.pharmaresearchlibrary.com/ijmpr Research

More information

Optimization of valsartan tablet formulation by 2 3 factorial design

Optimization of valsartan tablet formulation by 2 3 factorial design Research Article ISSN: 0974-6943 K. P. R. Chowdary et al. / Journal of Pharmacy Research 2014,8(9, Available online through http://jprsolutions.info Optimization of valsartan tablet formulation by 2 3

More information

FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF RAMIPRIL

FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF RAMIPRIL P a g e 9 Asian Journal of PHARMACEUTICAL RESEARCH Journal homepage: - www.ajprjournal.com e-issn 2231 363X Print ISSN 2231 3621 FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF RAMIPRIL A. Rajesh*,

More information

Volume: I: Issue-2: Aug-Oct ISSN NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE

Volume: I: Issue-2: Aug-Oct ISSN NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE Volume: I: Issue-2: Aug-Oct -2010 ISSN 0976-4550 NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE * Hindustan Abdul Ahad, Anuradha CM, Chitta Suresh

More information

Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets

Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets M. Sunitha Reddy 1, B. Sharath Reddy 1, S. Muhammed Fazal Ul Haq 1 Centre of Pharmaceutical Sciences, Jawaharlal Nehru Technological

More information

Formulation and Evaluation of Mouth Dissolving Sublingual Tablets of Cimetidine to Treat Abdominal Cramps

Formulation and Evaluation of Mouth Dissolving Sublingual Tablets of Cimetidine to Treat Abdominal Cramps International Journal of Pharmaceutical Science Invention ISSN (Online): 2319 6718, ISSN (Print): 2319 670X Volume 3 Issue 9 September 2014 PP.41-46 Formulation and Evaluation of Mouth Dissolving Sublingual

More information

Scholars Research Library. Formulation and evaluation of rizatriptan benzoate orodispersible tablets

Scholars Research Library. Formulation and evaluation of rizatriptan benzoate orodispersible tablets Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3 (6):125-130 (http://scholarsresearchlibrary.com/archive.html) ISSN 0974-248X USA CODEN: DPLEB4

More information

FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS

FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS G. Subba Rao

More information

COMPARATIVE EFFECT OF DIFFERENT HIGH FUNCTIONALITY EXCIPIENTS ON VARIOUS CHARACTERISTICS OF VARDENAFIL HCL TABLETS (BCS II DRUG)

COMPARATIVE EFFECT OF DIFFERENT HIGH FUNCTIONALITY EXCIPIENTS ON VARIOUS CHARACTERISTICS OF VARDENAFIL HCL TABLETS (BCS II DRUG) IJPSR (2014), Vol. 5, Issue 12 (Research Article) Received on 27 April, 2014; received in revised form, 28 July, 2014; accepted, 08 August, 2014; published 01 December, 2014 COMPARATIVE EFFECT OF DIFFERENT

More information

Available Online through Research Article

Available Online through Research Article ISSN: 0975-766X Available Online through Research Article www.ijptonline.com DESIGN AND EVALUATION OF GASTRORETENTIVE TABLETS FOR CONTROLLED DELIVERY OF NORFLOXOCIN Ganesh Kumar Gudas*, Subal Debnath,

More information

Gomathi J. et al. / International Journal of Biopharmaceutics. 2014; 5(4): International Journal of Biopharmaceutics

Gomathi J. et al. / International Journal of Biopharmaceutics. 2014; 5(4): International Journal of Biopharmaceutics 265 e- ISSN 0976-1047 Print ISSN 2229-7499 International Journal of Biopharmaceutics Journal homepage: www.ijbonline.com IJB FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF PROCHLORPERAZINE MALEATE

More information

Int. Res J Pharm. App Sci., 2014; 4(1):47-51 ISSN:

Int. Res J Pharm. App Sci., 2014; 4(1):47-51 ISSN: International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2014; 4(1):47-51 Research Article FORMULATION AND EVALUATION

More information

International Journal of Chemistry and Pharmaceutical Sciences

International Journal of Chemistry and Pharmaceutical Sciences Ramesh Naik M et al IJCPS, 2014, Vol.2(11): 1259-1264 Research Article ISSN: 2321-3132 International Journal of Chemistry and Pharmaceutical Sciences Fabrication and Evaluation of Montelukastsodium Sustained

More information

Formulation and Optimization of Lamotrigin Fast Dissolving Tablet

Formulation and Optimization of Lamotrigin Fast Dissolving Tablet Formulation and Optimization of Lamotrigin Fast Dissolving Tablet Sachin S. Gupta 1, Hitesh Patel 2, B.G.Prajapati 2, Shreeraj Shah 1 1. L.J.Institute of Pharmacy.Sanand Cross road, Sarkhej-Gandhinagar

More information

DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG

DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article DESIGN AND CHARACTERIZATION OF FLOATING TABLETS OF ANTI-DIABETIC DRUG M Seth *, DS Goswami,

More information

Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch

Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch Abstract K.P.R. Chowdary et al. / International Journal of Pharma Sciences and Research (IJPSR) Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch K.P.R. Chowdary*,

More information

Maisammaguda, Dulapally, Secundrabad.

Maisammaguda, Dulapally, Secundrabad. 121 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 3(6): November-December 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY

More information

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE FORMULATION AND EVALUATION OF PAROXETINE HYDROCHLORIDE ORODISPERSIBLE TABLETS USING TAPIOCA STARCH A. BHARATHI *, K N V DEEPTHI, S. BHAGYA

More information

Asian Journal of Research in Pharmaceutical Sciences and Biotechnology

Asian Journal of Research in Pharmaceutical Sciences and Biotechnology Research Article ISSN: 2349-7114 Asian Journal of Research in Pharmaceutical Sciences and Biotechnology Journal home page: www.ajrpsb.com FORMULATION, IN VITRO DRUG RELEASE AND STABILITY STUDIES OF CLOPIDOGREL

More information

DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL

DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL Isha Shah, Alpesh Yadav, Shailendra Bhatt Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India-3000. Abstract

More information

Design and development of fast Melting Tablets of Terbutaline Sulphate

Design and development of fast Melting Tablets of Terbutaline Sulphate Design and development of fast Melting Tablets of Terbutaline Sulphate Mathew T and Agrawal S Swami Vivekanand College of Pharmacy, Khandwa Road, Indore (MP), INDIA Available online at: www.isca.in (Received

More information

Design and evaluation of immediate release tablets of divalproex sodium

Design and evaluation of immediate release tablets of divalproex sodium Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (5):87-92 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

Available online Research Article

Available online   Research Article Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 26, 8(2):7-7 Research Article ISSN : 975-7384 CODEN(USA) : JCPRC5 Optimization of directly compressible mixtures of microcrystalline

More information

Formulation and Evaluation of Gastroretentive Dosage form of Ciprofloxacin Hydrochloride.

Formulation and Evaluation of Gastroretentive Dosage form of Ciprofloxacin Hydrochloride. Available online on www.ijcpr.com International Journal of Current Pharmaceutical Review and Research, 3(4), 105-109 Research Article ISSN: 0976-822X Formulation and Evaluation of Gastroretentive Dosage

More information

Formulation and development of orodispersible tablet of Memantine HCl by sublimation approach

Formulation and development of orodispersible tablet of Memantine HCl by sublimation approach Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (1):354-360 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

Formulation and In-Vitro Evaluation of Leflunomide Tablet with Enhanced Dissolution

Formulation and In-Vitro Evaluation of Leflunomide Tablet with Enhanced Dissolution ISSN 2395-3411 Available online at www.ijpacr.com 486 Research Article Formulation and In-Vitro Evaluation of Leflunomide Tablet with Enhanced Dissolution Ghanshayma M. Patil*, Harshal K. Patil, Vipul

More information

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Research Journal of Pharmaceutical, Biological and Chemical Sciences Research Journal of Pharmaceutical, Biological and Chemical Sciences Development and characterisation of oral fast dissolving tablet of nifedipine using camphor as a subliming material Shinde Anilkumar

More information

International Journal of Pharmacy

International Journal of Pharmacy International Journal of Pharmacy Journal Homepage: http://www.pharmascholars.com Research Article CODEN: IJPNL6 FORMULATION AND EVALUATION OF ZOLMITRIPTAN FAST DISSOLVING TABLET USING SYNTHETIC SUPERDISINTEGRANTS

More information

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF VALSARTAN

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF VALSARTAN Research article FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF VALSARTAN ABSTRACT C.P. JAIN 1 AND P.S. NARUKA 2 1. Department of Pharmaceutical Sciences, M.L.S. University, Udaipur. 2. Department

More information

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES Int. J. Chem. Sci.: 10(1), 2012, 297-305 ISSN 0972-768X www.sadgurupublications.com FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES K. P.

More information

Formulation and Evaluation of Fast Disintegrating Tablets of Caffeine by Using Effervescent Formulation Approach

Formulation and Evaluation of Fast Disintegrating Tablets of Caffeine by Using Effervescent Formulation Approach Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 212, 4 (5):149-1494 (http://scholarsresearchlibrary.com/archive.html) ISSN 975-571 USA CODEN: DPLEB4

More information

FORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE CONTAINING MULTICOMPONENT INCLUSION COMPLEX

FORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE CONTAINING MULTICOMPONENT INCLUSION COMPLEX Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Issue 1, 2012 Research Article FORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE

More information

Karnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS:

Karnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS: 335 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 4(6): November-December 2015 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY

More information

DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS

DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS Chinmaya Keshari Sahoo* 1, Tanmaya Keshari Sahoo 2 and

More information

World Journal of Pharmaceutical and Life Sciences WJPLS

World Journal of Pharmaceutical and Life Sciences WJPLS wjpls, 2019, Vol. 5, Issue 1, 63-70 Research Article ISSN 2454-2229 Parveen et al. WJPLS www.wjpls.org SJIF Impact Factor: 5.008 FORMULATION AND DEVELOPMENT OF ENALAPRIL MALEATE FAST DISSOLVING TABLETS

More information

FORMULATION AND EVALUATION OF FAST DISPERSIBLE TABLETS OF CITALOPRAM HYDROBROMIDE

FORMULATION AND EVALUATION OF FAST DISPERSIBLE TABLETS OF CITALOPRAM HYDROBROMIDE Page1371 Indo American Journal of Pharmaceutical Research, 2013. ISSN NO: 2231-6876 Journal home page: http:///index.php/en/ INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH FORMULATION AND EVALUATION

More information

International Journal of Pharma and Bio Sciences NOVEL CO-PROCESSED SUPERDISINTEGRANTS IN THE DESIGN OF FAST DISSOLVING TABLETS

International Journal of Pharma and Bio Sciences NOVEL CO-PROCESSED SUPERDISINTEGRANTS IN THE DESIGN OF FAST DISSOLVING TABLETS S.B.Shirsand*, R. G. Ramani, P.V.Swamy Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Sedam Road, Gulbarga-585 105, India * Correspondence Address shirsand@rediffmail.com

More information

Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants

Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants ISSN: 2231-3354 Received on: 13-11-2011 Revised on: 18:11:2011 Accepted on: 22-11-2011 Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants Leela

More information

ISSN: CODEN Code: PIHNBQ ZDB-Number: IC Journal No: Vol. 2 No Online Available at

ISSN: CODEN Code: PIHNBQ ZDB-Number: IC Journal No: Vol. 2 No Online Available at Received: 2-01-201 Accepted: 09-0-201 ISSN: 2277-795 CODEN Code: PIHNBQ ZDB-Number: 208-2 IC Journal : 7725 Vol. 2. 2 201 Online Available at www.thepharmajournal.com THE PHARMA INNOVATION - JOURNAL Formulation

More information

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 975-1491 Vol 4, Suppl 5, 212 FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE

More information

Formulation Development and Evaluation of Antidiabetic Polyherbal Tablet

Formulation Development and Evaluation of Antidiabetic Polyherbal Tablet Research Article Formulation Development and Evaluation of Antidiabetic Polyherbal Tablet Komal Patel 1*, Lal Hingorani 2, Vinit Jain 3 1 School of Pharmacy, RK University, Rajkot and Parul Institute of

More information

PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE VEHICLE IN TABLET FORMULATIONS

PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE VEHICLE IN TABLET FORMULATIONS INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE

More information

Formulation and Evaluation of Etoricoxib Oro Dispersable Tablets by Direct Compression Method

Formulation and Evaluation of Etoricoxib Oro Dispersable Tablets by Direct Compression Method IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-issn:2278-3008, p-issn:2319-7676. Volume 11, Issue 2 Ver. III (Mar.- Apr.2016), PP 64-70 www.iosrjournals.org Formulation and Evaluation of

More information

Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums

Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums 1368 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue 1 April-June 211 Research Paper International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue

More information

Formulation and evaluation of rapid disintegration tablets of moxifloxacin HCl

Formulation and evaluation of rapid disintegration tablets of moxifloxacin HCl Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2013, 5 (1):238-250 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

7. SUMMARY, CONCLUSION AND RECOMMENDATIONS

7. SUMMARY, CONCLUSION AND RECOMMENDATIONS 211 7. SUMMARY, CONCLUSION AND RECOMMENDATIONS Drug absorption from the gastro intestinal tract can be limited by various factors with the most common one being poor aqueous solubility and poor permeability

More information

Asian Journal of Medical and Pharmaceutical Sciences. Asian Journal of Medical and Pharmaceutical Sciences

Asian Journal of Medical and Pharmaceutical Sciences. Asian Journal of Medical and Pharmaceutical Sciences Y. Krishna Reddy et al, AJMPS, 2016, 4(1): 11 16 ISSN: 2348-0165 Asian Journal of Medical and Pharmaceutical Sciences Journal Home Page: www.pharmaresearchlibrary.com/ajmps Research Article Open Access

More information

FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS

FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.1, No.4, pp 1381-1385, Oct-Dec 2009 FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS

More information

FORMULATION DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLET OF TRAMADOL HYDROCHLORIDE

FORMULATION DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLET OF TRAMADOL HYDROCHLORIDE Vol 6, Suppl 3, 2013 ISSN - 0974-2441 Research Article FORMULATION DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLET OF TRAMADOL HYDROCHLORIDE ABSTRACT SONALI J. SHAH *, RUPA MAZUMDER Department of

More information

Design and Characterization of Valsartan Loaded Press Coated Pulsatile Tablets

Design and Characterization of Valsartan Loaded Press Coated Pulsatile Tablets Research Reviews: Pharmacy & Pharmaceutical Sciences e-issn: 2320-1215 www.rroij.com Design and Characterization of Valsartan Loaded Press Coated Pulsatile Tablets Sowjanya Battu*, Madhavi K, Bhikshapathi

More information

Asian Journal of Biochemical and Pharmaceutical Research

Asian Journal of Biochemical and Pharmaceutical Research ISSN: 2231-2560 Research Article Asian Journal of Biochemical and Pharmaceutical Research Design and Evaluation of Gastroretentive Floating Tablets of Dipyridamole: Influence of Formulation Variables A.

More information

International Journal of Pharma and Bio Sciences FORMULATION AND EVALUATION OF TASTE MASKED DISPERSIBLE TABLETS OF ZIDOVUDINE YASH PAUL ABSTRACT

International Journal of Pharma and Bio Sciences FORMULATION AND EVALUATION OF TASTE MASKED DISPERSIBLE TABLETS OF ZIDOVUDINE YASH PAUL ABSTRACT International Journal of Pharma and Bio Sciences RESEARCH ARTICLE PHARMACEUTICS FORMULATION AND EVALUATION OF TASTE MASKED DISPERSIBLE TABLETS OF ZIDOVUDINE YASH PAUL* 1, SARVAN TYAGI 1 AND BHUPINDER SINGH

More information

Preformulation Study. CHAPTER 3 Preformulation Study. 3.0 Introduction

Preformulation Study. CHAPTER 3 Preformulation Study. 3.0 Introduction CHAPTER 3 3.0 Introduction As per Sir Arthur Conan Doyle, It is a capital mistake to theorize before one has data. Preformulation work is the foundation for development of any robust formulations (G. Banker

More information

Formulation Development and Evaluation of Atorvastatin Calcium Tablets using Co-Processed Excipients

Formulation Development and Evaluation of Atorvastatin Calcium Tablets using Co-Processed Excipients Int. J. Pharm. Sci. Rev. Res., 36(1), January February 2016; Article No. 39, Pages: 217222 Research Article Formulation Development and Evaluation of Atorvastatin Calcium Tablets using CoProcessed Excipients

More information