Overview of ARV-based prevention trials
|
|
- Moris Phelps
- 6 years ago
- Views:
Transcription
1 Overview of ARV-based prevention trials Catherine Hankins BA MD MSc CCFP FRCPC Deputy Director, Science Amsterdam Institute for Global Health and Development; Department of Global Health, Academic Medical Centre, University of Amsterdam Honorary Professor Department of Infectious Disease Epidemiology London School of Hygiene and Tropical Medicine IAS-ILF Satellite at CROI 2013 Sex and Gender Differences in ARV-based Prevention Research, March 3, 2013, Atlanta
2 Overview of ARV-based prevention trials u Place of ARV-based prevention in combination prevention u Pre-exposure prophylaxis trials u Early treatment for prevention: HPTN 052 u Treatment as prevention: prevention benefits of scaling up treatment following national eligibility criteria
3 Hankins and De Zalduondo AIDS 2010 Combination Prevention: Basic Attributes Evidence-informed, human rights-based, and context-specific, tailored to local epidemics and needs Fully engages affected communities, promoting human rights and gender equality Operates synergistically on multiple levels individual, family and society Invests in decentralized and community responses Flexible adapts to changing epidemic patterns and rapidly deploys innovations Combines biomedical, behavioural and structural elements to address immediate risks, underlying vulnerabilities, and pathways that link them
4 Mellors Antiretroviral Prevention Train
5 HIV prevention with ARVs (since 2010) HIV prevention (before 2010) Topical preexposure prophylaxis (microbicides) for women Abdool Karim Q, Science 2010 Oral pre-exposure prophylaxis Grant R, NEJM 2010 (MSM) Baeten J, NEJM 2012 (Couples) Thigpen M, NEJM 2012 (Heterosexuals) Treatment for prevention Cohen M, NEJM 2011 Note: PMTCT, Screening transfusions, Harm reduction, Universal precautions, Vaccines, etc. have not been included HIV PREVENTION Male circumcision Auvert B, PloS Med 2005 Gray R, Lancet 2007 Bailey R, Lancet 2007 Treatment of STIs Grosskurth H, Lancet 2000 Female Condoms Male Condoms HIV Counselling &Testing Coates T, Lancet 2000 Behavioural Intervention - Abstinence - Be Faithful
6 Antiretroviral Drugs for Preventing Sexual HIV Transmission Antiretroviral therapy for HIV+ persons Ø Reduces onward HIV transmission T4P: early treatment for prevention before CD4+ cells reach 350/uL TasP: treatment as prevention i.e. populationlevel benefits of lower community viral load with ART scale-up following national eligibility criteria Antiretroviral prophylaxis for HIV- persons Ø Reduces HIV acquisition Pre-exposure prophylaxis to prevent sexual transmission: è ; è ; è
7 HIV Prevention Options Timeline * ** AVAC, January Oral TDF/FTC Oral TDF TFV gel Rectal TFV gel DPV Ring TMC 278 LA Inject. GSK LAP DNA/Ad Bangkok Tenofovir Study/CDC 4370 TIMELINE LEGEND Oral TDF 2008 Partners PrEP Partners PrEP (no placebo) Positive efficacy result Oral TDF/FTC 2009 VOICE/MTN TDF2/CDC 4940 TDF2 Open-Label Extension 2007 iprex iprex Open-Label Extension (OLE) 2009 FEM-PrEP 2007 CAPRISA VOICE/MTN HVTN 505 FACTS 001 US FDA approval MTN 017 The Ring Study/IPM 027 ASPIRE/MTN 020 Additional demonstration projects & intermittent PrEP studies CAPRISA 008 Various phase I TMC278 LA injectable trials (SSAT 040 & MWRI-01) Arm stopped Regulatory submission/filing Planned Final results pending FACTS 002 and other adolescent studies TFV gel Rectal TFV gel DPV ring TMC278 LA Injectable DNA/Ad5 Pox-Protein GSK LAP Earliest regulatory submission Possible LA Injectable Efficacy Trial Earliest regulatory submission South Africa Licensure Study Pox-Protein RV Various Phase I/II preliminary and bridging studies * Trial end-dates are estimates; due to the nature of clinical trials the actual dates may change. For full trial details, see ** Not all trials included are effectiveness trials. Trials included on this list are mainly phase II/IIb, III/IIIb and IV trials. Southern Africa Research Study Thai Licensure Study
8 Key requirements for effective PrEP People Right drug (safe, effective, minimal resistance) Right place (sufficient concentrations at site of HIV exposure) Right time (short onset of activity and long half-life to optimize efficacy with variable adherence) Right population (at risk, motivated to use) Right timing (during periods of highest risk) Right delivery (cost-effective and efficient) Right decision-making (equity issues: prioritising key populations at highest risk of exposure MSM, SW, PWID, young women while fully scaling up ART)
9 Pre-exposure prophylaxis strategies Tenofovir (TDF) Tenofovir/emtricitabine TDF/FTC ü Partners PrEP Topical PrEP: 1% tenofovir gel ü iprex ü Partners PrEP ü TDF2 ü CAPRISA 004 Injectable PrEP: subcutaneous or intramuscular (Phase 1 trials)) Intermittent PrEP trials ASPIRE and IPM trials
10 Tenofovir-based px results, as of Feb 2013 Study Popula,on N Results CAPRISA 004 South Africa iprex Brazil, Ecuador, Peru, South Africa, Thailand, US TDF2 Study Botswana Women 889 Gay men, other MSM, transgender women 39% [CI = 6-60] efficacy coitally- dependent vaginal TFV gel % [CI = 18-60] efficacy daily oral FTC/TDF Men and women % [CI = 22-83] efficacy daily oral FTC/TDF Partners PrEP Study Kenya, Uganda FEM- PrEP Kenya, S Africa, Tanzania VOICE South Africa, Uganda, Zimbabwe Bangkok Tenofovir Study Thailand FACTS 001 South Africa Serodiscordant couples 4758 Women 1950 Women 5029 IDUs 2400 Women % [CI = 44-81] efficacy daily oral TDF 75% [CI = 55-87] efficacy daily oral FTC/TDF FuQlity of daily oral FTC/TDF 6% [CI = ] FuQlity of daily oral TDF FuQlity of daily vaginal TFV gel Daily oral FTC/TDF ongoing Results expected at CROI, March 2013 Daily oral TDF ongoing Results expected by June 2013 Coitally- dependent vaginal TFV gel enrolling Results expected in 2015
11 Pre-Exposure Prophylaxis for Women as of March Trial CAPRISA 004 VOICE gel [daily] Country 1% Tenofovir vaginal gel Oral TDF (tenofovir) daily tablets Oral TDF/FTC (emtricitabine) daily tablets South Africa - - Uganda, South Africa, Zimbabwe X - - FACTS 001 South Africa? - - Fem PrEP Ken, SA, Tanz - - X VOICE oral Uga, SA, Zim - X? Partners PrEP Kenya, Uganda - TDF-2 Botswana - - Hankins
12 Research and Development Pipeline: New Trials MSM populations: Intermittent PrEP (IPERGAY, France): TDF/FTC versus placebo [controversy post FDA announcement] ADAPT (HPTN 067): daily versus intermittent TDF/FTC [no point in testing unpopular regimens] NEXT-PREP (HPTN 069): TDF/FTC +/- maraviroc [CCR5 blocker not used much in treatment] PROUD: UK immediate vs deferred TDF/FTC Women: Ring study (IPM) & ASPIRE (MTN) phase III dapivirine ring Safety and acceptability Follow-up to Phase I trials of long-acting injectables NNRTI rilpivirine (TMC 278) and integrase inhibitor S/GSK
13 HPTN 052: HIV-1 Transmission (Cohen et all NEJM 2011) Total HIV-1 Transmission Events: 39 Linked Transmissions: 28 96% reduction Unlinked or TBD Transmissions: 11 Immediate Arm: 1 p < Delayed Arm: stable, healthy, serodiscordant, sexually active couples in 9 countries [CD4 count: 350 to 550 cells/mm 3 ] randomised for the HIV+ partner to: start ART immediately or wait until CD4 250
14 ART coverage Hlabisa, KwaZulu Natal HIV-infected: Individual, geo-located, HIV + adults identified through population-based HIV surveillance ( ) Patients on ART: Individual, geo-located adult patients actively on ART in June ( ) ART coverage: % all HIV-infected population receiving ART At 30-40% ART coverage, HIV acquisition hazard reduced by 38% (1.4% for 1% ART increase) Tanser et al CROI 2012 and Science 2013
15 Overview of ARV-based prevention trials u Place of ARV-based prevention in combination prevention u Pre-exposure prophylaxis trials u Early treatment for prevention: HPTN 052 u Treatment as prevention: prevention benefits of scaling up treatment following national eligibility criteria
16 With thanks for ideas and slides to: Helen Weiss Frank Tanser Salim Abdool Karim Mitchell Warren Myron Cohen John Mellors Bob Grant Jared Beaton Connie Celum Quarraisha Abdool Kevin O Reilly Karim Brazey De Zalduondo Thank you for your attention!
TasP - Individual versus Public Health Benefit versus Both.
Site Map l Contact Us l Calendar l Join AVAC Donate TasP - Individual versus Public Health Benefit versus Both. Kevin Fisher Policy Director, AVAC June 2012 Multiple choice answer: all of the above We
More informationAntiretroviral Drugs for HIV Seronegative People: It works in trials, what about the real world?
Antiretroviral Drugs for HIV Seronegative People: It works in trials, what about the real world? Lut Van Damme 11 Oct 2012 1 Disclaimer Gilead donated the study product for the FEM-PrEP trial I participated
More informationUse of Pre-exposure Prophylaxis (PrEP) in pregnancy for primary prevention of HIV infection in women
Use of Pre-exposure Prophylaxis (PrEP) in pregnancy for primary prevention of HIV infection in women Catherine Hankins MD PhD FRCPC CM Deputy Director, Science Amsterdam Institute for Global Health and
More informationBiomedical Prevention Update Thomas C. Quinn, M.D.
Biomedical Prevention Update Thomas C. Quinn, M.D. Associate Director of International Research National Institute of Allergy and Infectious Diseases Director, Johns Hopkins Center for Global Health Global
More informationRoy M. Gulick, MD, MPH Chief, Division of Infectious Diseases Professor of Medicine Weill Medical College of Cornell University New York City
PrEP 2013 Roy M. Gulick, MD, MPH Chief, Division of Infectious Diseases Professor of Medicine Weill Medical College of Cornell University New York City Slide #2 U.S.: New HIV Infections Per Year ~50,000
More informationART and Prevention: What do we know?
ART and Prevention: What do we know? Biomedical Issues Trip Gulick, MD, MPH Chief, Division of Infectious Diseases Professor of Medicine Weill Cornell Medical College New York City ART for Prevention:
More informationInspiring HIV Prevention Innovations for Women. IPM Satellite Event Durban, 13 th June 2017 Annalene Nel
Inspiring HIV Prevention Innovations for Women IPM Satellite Event Durban, 13 th June 2017 Annalene Nel HIV Infection: Where We Are Today 30+ years since the US CDC reported the first cases of AIDS 25.5
More informationCombination prevention: Public health and human rights imperatives
Combination prevention: Public health and human rights imperatives Gottfried Hirnschall, MD MPH HIV/AIDS Department WHO, Geneva London, June 11, 2012 Outline The epidemic and response What is combination
More informationUpdate on ARV based PrEP
Update on ARV based PrEP Z Mike Chirenje MD FRCOG University of Zimbabwe, College of Health Sciences, Dept. of Obstetrics and Gynaecology Avondale, Harare, Zimbabwe chirenje@uz-ucsf.co.zw Controlling HIV
More informationWhere are we going after effectiveness studies?
Where are we going after effectiveness studies? Nyaradzo M. Mgodi (MBChB, MMed) UZ-UCSF Collaborative Research Program Harare, Zimbabwe MTN Annual Meeting 28 March 2011, Arlington, VA Introduction 30 years
More informationPre-exposure prophylaxis : Systemic and topical. Linda-Gail Bekker The Desmond Tutu HIV Centre UCT SA HIV ClniciansSociety Conference 2012
New biomedical technologies. Pre-exposure prophylaxis : Systemic and topical. Linda-Gail Bekker The Desmond Tutu HIV Centre UCT SA HIV ClniciansSociety Conference 2012 And the last parachute goes to..
More informationHIV Treatment Evolution. Kimberly Y. Smith MD MPH Vice President and Head, Global Research and Medical Strategy Viiv Healthcare
HIV Treatment Evolution Kimberly Y. Smith MD MPH Vice President and Head, Global Research and Medical Strategy Viiv Healthcare Overview of the Evolution of Antiretroviral Therapy Early Treatment 1987
More informationThe Open Label Trial Past and Present
The Open Label Trial Past and Present Jared Baeten, M.D., Ph.D. University of Washington Beyond Phase III: Seeking civil society perspectives on next steps with the dapivirine ring for HIV prevention in
More informationUnderstanding the Results of VOICE
CONTACT: Lisa Rossi +1-412- 916-3315 (mobile) or +27-(0)73-323-0087 (through 7 March) rossil@upmc.edu About VOICE Understanding the Results of VOICE VOICE Vaginal and Oral Interventions to Control the
More informationPrEP Dosing Strategies
PrEP Dosing Strategies Outline o Background PrEP absorption and tissue penetration o Oral versus topical o Lead in and lead out dosing Time to protection o Cycling on and off PrEP o Balancing toxicity
More informationThe Open Label Trial Past and Present
The Open Label Trial Past and Present Patrick Ndase, MBChB, M.P.H University of Washington Beyond Phase III: Seeking civil society perspectives on next steps with the dapivirine ring for HIV prevention
More informationCombination HIV Prevention
Combination HIV Prevention Timothy Mastro, MD, FACP, DTM&H FHI 360, Durham, North Carolina, USA 7 th INTEREST Workshop, Dakar, Senegal 15 May 2013 Outline What Works for HIV Prevention? Highly Active
More informationTranslating the Science to End New HIV Infections in Kenya
Translating the Science to End New HIV Infections in Kenya Perspectives, Practices and Lessons Nairobi, 28-30 May 2017 www.iasociety.org AIDS 2016 Post-Conference Workshop Setting the Stage Overview of
More informationProfessor Thomas Quinn Johns Hopkins Center for Global Health, Maryland, USA
17 TH ANNUAL CONFERENCE OF THE BRITISH HIV ASSOCIATION (BHIVA) Professor Thomas Quinn Johns Hopkins Center for Global Health, Maryland, USA 6-8 April 2011, Bournemouth International Centre 17 TH ANNUAL
More informationHIV Prevention Strategies HIV Pre-exposure prophylaxis
HIV Prevention Strategies HIV Pre-exposure prophylaxis Michael Martin, MD, MPH Director HIV Research Program Thailand MOPH U.S. CDC Collaboration The findings and conclusions in this presentation are those
More informationPrEP efficacy the evidence
PrEP efficacy the evidence Dr Michael Brady Consultant, HIV and Sexual Health King s College Hospital, London Medical Director Terrence Higgins Trust PrEP Pre-exposure prophylaxis Tenofovir and emtricitabine
More informationART and Transmission. Martin Fisher. Brighton and Sussex University Hospitals, UK
ART and Transmission Martin Fisher Brighton and Sussex University Hospitals, UK 11th Advanced HIV Course Aix-en-Provence 2013 New HIV diagnoses by exposure group: United Kingdom, 2002 2011 1 Predicted
More informationARVs for prevention in at-risk populations: Microbicides
ARVs for prevention in at-risk populations: Microbicides Treatment as Prevention in Africa Meeting Botswana, April 30 May 3, 2014 Salim S Abdool Karim Director: CAPRISA Pro Vice-Chancellor (Research):
More informationAntiretrovirals for HIV prevention:
Antiretrovirals for HIV prevention: Topical PrEP, Systemic PrEP and Treatment for Prevention Presentation at 6th International workshop on HIV treatment, pathogenesis and prevention research in resource-limited
More informationDr Valérie Martinez-Pourcher
Educa&ng Nurses About An&retrovirals and HIV Preven&on - State of the Science, Uptake Challenges, and Barriers Dr Valérie Martinez-Pourcher Pitié-Salpêtrière Hospital Paris We need to control HIV replication
More informationThe Big Picture: The current and evolving HIV prevention landscape
The Big Picture: The current and evolving HIV prevention landscape Patrick Ndase, MBChB, M.P.H University of Washington Beyond Phase III: Seeking stakeholder perspectives on next steps with the for HIV
More information11/8/2016. Moving Beyond Truvada: The (Current) Future Pipeline for PrEP. Prevention Modalities
Moving Beyond Truvada: The (Current) Future Pipeline for PrEP Raphael J. Landovitz, MD MSc Associate Professor of Medicine UCLA Center for Clinical AIDS Research & Education November 18, 2016 2 Million
More informationHIV: Pregnancy in Serodiscordant Couple. Dr Chow TS ID Clinic HPP
HIV: Pregnancy in Serodiscordant Couple Dr Chow TS ID Clinic HPP Sexual Reproductive Health and Rights The recognition of the sexual and reproductive health and rights (SRHR) of all individuals and couples
More informationETHICS IN HIV PREVENTION RESEARCH IN THE NEW ERA OF
ETHICS IN HIV PREVENTION RESEARCH IN THE NEW ERA OF PrEP MTN Regional Meeting Cape Town 20 September 2017 Dhevium Govender South African Medical Research Council HIV Prevention Research Unit Quality/Regulatory
More informationDisclosure. Learning Objectives. Epidemiology. Transmission. Risk of Transmission PRE-EXPOSURE PROPHYLAXIS (PREP) FOR HIV PREVENTION 50,000.
Disclosure PRE-EXPOSURE PROPHYLAXIS (PREP) FOR HIV PREVENTION I have no financial interest in and/or affiliation with any external organizations in relation to this CE program. DaleMarie Vaughan, PharmD
More informationPREPARING FOR PREP: FROM KEY POPULATIONS THEORY TO PRACTICE. Dr Oscar Radebe
PREPARING FOR PREP: FROM THEORY TO PRACTICE KEY POPULATIONS Dr Oscar Radebe PrePARINGFOR THE END OF HIV Until recently there has been exciting new advances in clinical research focusing on HIV prevention
More informationDrug development in relation to PrEP and the PROUD study
Drug development in relation to PrEP and the PROUD study David Dolling Medical Statistician MRC Clinical Trials Unit 18 th October 2012 What is PrEP? - Pre-exposure Prophylaxis A strategy that uses antiretrovirals
More informationAdolescent PrEP Delivery: Strategies and Tools to Maximize Adherence Young Women in Africa. Jessica Haberer, MD, MS November 9, 2017
Adolescent PrEP Delivery: Strategies and Tools to Maximize Adherence Young Women in Africa Jessica Haberer, MD, MS November 9, 2017 Disclosures I have no conflicts to declare Grant funding: NIH, Gates
More informationUpdate on PrEP progress: WHO/UNAIDS challenges and actions
Update on PrEP progress: WHO/UNAIDS challenges and actions Kevin R. O'Reilly Prevention in the Health Sector, HIV/AIDS Department, WHO HQ Outline Review current status of PrEP Planning for PrEP Pre-exposure
More informationPrEP: Pre Exposure Prophylaxis
PrEP: Pre Exposure Prophylaxis Lyn Stevens, NP, MS, ACRN Deputy Director Office of the Medical Director NYS Department of Health, AIDS Institute Faculty Disclosure Lyn Stevens No relationships to disclose
More informationCombination HIV Prevention Research Carl W. Dieffenbach, Ph.D.
Combination HIV Prevention Research Carl W. Dieffenbach, Ph.D. Director, Division of AIDS, NIAID, NIH October 13, 2011 Multiple strategies needed to assemble a wellrounded prevention toolkit Know the epidemics
More informationThe Science behind Preexposure Prophylaxis (PrEP) Yunus Moosa Department of Infectious Diseases UKZN
The Science behind Preexposure Prophylaxis (PrEP) Yunus Moosa Department of Infectious Diseases UKZN 1 Ongoing HIV transmission despite expanding access to ART SA 18 16 14 12 10 8 6 4 2 0 Treatment exposure
More informationPEP and PrEP: AWAAC 2014
Acknowledgements: HIVCS PEP guidelines group, Helen Rees, Slim Abdool Karim, Quarraisha Abdool Karim, Clinical Care Options, Edwina Wright, Jared Baeton, AETC PEP and PrEP: AWAAC 2014 Francois Venter Wits
More informationThe Big Picture: The current and evolving HIV prevention landscape
The Big Picture: The current and evolving HIV prevention landscape Sharon Hillier, Ph.D. University of Pittsburgh Beyond Phase III: Seeking civil society perspectives on next steps with the dapivirine
More informationHIV In South Africa: Turning the Tide of the Epidemic
HIV In South Africa: Turning the Tide of the Epidemic Jean B. Nachega, MD, PhD Associate Professor Department of Epidemiology Pittsburgh University, Graduate School of Public Health E-mail: JBN16@PITT.EDU
More informationPre-Exposure Prophylaxis (PrEP) 1 Prevention of HIV in At-Risk Women:
Pre-Exposure Prophylaxis (PrEP) 1 Prevention of HIV in At-Risk Women: Coming of Age Aaron Kofman, BA, MD 14 Eli Y. Adashi, MD, MS, CPE, FACOG BRIGHT Series June 12, 2012 Women and the HIV Epidemic Global
More informationPre-exposure Prophylaxis (PrEP)
Pre-exposure Prophylaxis (PrEP) Kenneth Mayer, MD Fenway Health Beth Israel Deaconess Medical Center Harvard Medical School and School of Public Health Treatment As Prevention in Africa Workshop May 2
More informationUsing anti-hiv drugs for prevention
Using anti-hiv drugs for prevention Highlights from AIDS 2012 (and 2 nd International Workshops on Treatment as Prevention) Tim Rogers, trogers@catie.ca Using anti-hiv Drugs for Prevention Outline Treatment
More informationPre-Exposure Prophylaxis: The New Frontier of Prophylaxis Against HIV Infection
Pre-Exposure Prophylaxis: The New Frontier of Prophylaxis Against HIV Infection William F. Ryan Community Health Network PrEP Network Coordinator: Trevor Hedberg, MPH, CPH Supervising Health Educator:
More informationMTN-020. Jared Baeten, MD PhD Thesla Palanee, PhD On behalf of the ASPIRE team MTN Annual Meeting, Bethesda 21 February 2012
MTN-020 Jared Baeten, MD PhD Thesla Palanee, PhD On behalf of the ASPIRE team MTN Annual Meeting, Bethesda 21 February 2012 MTN-020 / ASPIRE A Multi-Center, Randomized, Double- Blind, Placebo-Controlled
More informationStrategic use of antiretroviral drugs to prevent HIV transmission
Strategic use of antiretroviral drugs to prevent HIV transmission 22th Tunisian Congress of Infectious Diseases 2nd Congress of Federation of Arab Societies of Clinical Microbiology and Infectious Diseases
More informationWhere We Have Been and Where We are Going. Ian McGowan MD PhD FRCP
Where We Have Been and Where We are Going Ian McGowan MD PhD FRCP Directions Where we were Where we are headed Where we are 2005 The size of your dreams must always exceed your current capacity to achieve
More informationThe HIV Prevention Pill: The State of PrEP Science and Implementation. James Wilton Coordinator, Biomedical Science of HIV Prevention CATIE
The HIV Prevention Pill: The State of PrEP Science and Implementation James Wilton Coordinator, Biomedical Science of HIV Prevention CATIE Overview 1. The Basics 2. A review of the science 3. An update
More informationCan we treat our way out of the HIV epidemic?
Can we treat our way out of the HIV epidemic? Richard E. Chaisson, MD Center for AIDS Research Center for TB Research Johns Hopkins University Schoolboy s (and politician s) tricks for evading the question
More informationSupplementary Material Table 5. Ongoing PrEP studies among young key population, young people, and key populations. Age range. Study name and location
Supplementary Material Table 5. Ongoing PrEP studies among young key population, young people, and key populations Study name and location ADAPT (HPTN 067) South Africa, Thailand, US (Harlem) Bangkok Tenofovir
More informationUpdate on Biomedical Prevention. Thomas C. Quinn, MD, MSc
Update on Biomedical Prevention Thomas C. Quinn, MD, MSc Associate Director of International Research National Institute of Allergy and Infectious Diseases Director, Johns Hopkins Center for Global Health
More informationPRE-EXPOSURE PROPHYLAXIS FOR HIV: EVIDENCE AND GENDER CONSIDERATIONS. Jean R. Anderson M.D. Director, Johns Hopkins HIV Women s Health Program
PRE-EXPOSURE PROPHYLAXIS FOR HIV: EVIDENCE AND GENDER CONSIDERATIONS Jean R. Anderson M.D. Director, Johns Hopkins HIV Women s Health Program Disclosures None Objectives Review the evidence regarding the
More informationMoving beyond condoms to prevent HIV transmission. Are you Prepared for HIV PrEP?
Moving beyond condoms to prevent HIV transmission Are you Prepared for HIV PrEP? The Issues New HIV infections in the US continue Vast majority of infections are sexually acquired Condoms work but are
More informationPre-Exposure Prophylaxis (PrEP) A Biomedical Intervention Prevention with Negatives Antiretroviral Prevention
Pre-Exposure Prophylaxis (PrEP) A Biomedical Intervention Prevention with Negatives Antiretroviral Prevention New and Emerging Biomedical HIV Prevention Interventions Vaccines Vaginal microbicides Pre-exposure
More informationUpdate on Antiretroviral-Based HIV Prevention
Update on Antiretroviral-Based HIV Prevention Prof. Janneke van de Wijgert University of Liverpool, Institute of Infection and Global Health Click to edit Master subtitle style 12th European Meeting on
More informationQUESTIONS AND ANSWERS ABOUT PARTNERS PrEP AND VOICE
CONTACT: Lisa Rossi +1-412-641-8940 +1-412- 916-3315 (mobile) rossil@upmc.edu QUESTIONS AND ANSWERS ABOUT PARTNERS PrEP AND VOICE 1. What is the Partners PrEP study? The Partners PrEP Study is a double-blind,
More informationBiomedical Prevention in HIV
Biomedical Prevention in HIV CHART - CCAS-CDC 3 RD Joint Meeting Montego Bay, Jamaica August 21-26,2011 Presented by Tina Hylton-Kong, ERTU-CHART Some Slides from Impact of ART on HIV Transmission Wafaa
More informationWOMEN & HIV: A GLOBAL UPDATE. Deanna Kerrigan, PhD, MPH Associate Professor Health, Behavior & Society
WOMEN & HIV: A GLOBAL UPDATE Deanna Kerrigan, PhD, MPH Associate Professor Health, Behavior & Society Objectives Review the current global burden of HIV among women Trends and progress to date Groups with
More informationTransmission Networks & Risk of HIV Infection in Young Women in KwaZulu-Natal, South Africa
Transmission Networks & Risk of HIV Infection in Young Women in KwaZulu-Natal, South Africa FIDSSA, Cape Town, November 2017 Quarraisha Abdool Karim, PhD Associate Scientific Director: CAPRISA Professor
More informationHIV PREP THE NEWEST TOOL IN THE BOX
HIV PREP THE NEWEST TOOL IN THE BOX Infectious Disease Update November 7, 2014 Andrew Petroll, MD, MS Department of Medicine, Division of Infectious Diseases Department of Psychiatry and Behavioral Medicine,
More informationAn Update on the HIV Prevention Landscape: The Role of Combination Prevention
1 An Update on the HIV Prevention Landscape: The Role of Combination Prevention Susan Buchbinder, MD Bridge HIV, SFDPH; UCSF MTN Regional Meeting October 29, 2013 2 Overview 1. Why combination prevention?
More informationMucosal Assays in Oral and Long Acting (LA) Antiretroviral PrEP Trials. Ian McGowan MD PhD FRCP University of Pittsburgh Pittsburgh, PA USA
Mucosal Assays in Oral and Long Acting (LA) Antiretroviral PrEP Trials Ian McGowan MD PhD FRCP University of Pittsburgh Pittsburgh, PA USA Overview A brief history of oral/la PrEP research Integration
More informationNovel HIV Prevention Methods for Women
Novel HIV Prevention Methods for Women State of the art injectables, rings, and antibody-mediated prevention Nyaradzo M Mgodi (MBChB, MMed) Principal Investigator University of Zimbabwe- College of Health
More information8/25/2016. Making Preexposure Prophylaxis Available in the Clinic: Considerations and Pathways Forward
WORKSHOP SESSION: MAKING PREEXPOSURE PROPHYLAXIS AVAILABLE IN THE CLINIC: CONSIDERATIONS AND PATHWAYS FORWARD PRE-REGISTRATION IS REQUIRED PLEASE SEE THE CPT INFORMATION DESK IF THIS IS NOT YOUR SELECTED
More informationPREP EFFICACY AND IMPLEMENTATION WITHIN CLINICAL SETTINGS circle
PREP EFFICACY AND IMPLEMENTATION WITHIN CLINICAL SETTINGS circle Gifty-Maria Jane Ntim, MD, MPH October 6, 2016 Disclosures I have nothing to disclose. 30.1 Million HIV-Infected Adults World Wide: 56%
More informationWhat s in the Biomedical Prevention Pipeline
What s in the Biomedical Prevention Pipeline HIV Endgame: Closing Gaps in the Care Cascade Toronto, 24 th October 2016 Ian McGowan MD DPhil FRCP University of Pittsburgh Pittsburgh, PA, USA Presenter Disclosure
More informationM2010 Pre-Conference Workshop, Pittsburgh 22 May 2010
HIV Prevention Research: The Global Picture Presented at: M2010 Pre-Conference Workshop, Pittsburgh 22 May 2010 Salim S. Abdool Karim Pro Vice-Chancellor (Research): University of KwaZulu-Natal Director:
More informationPEP and PREP. Dr David Hawkins Chelsea and Westminster Hospital
PEP and PREP Dr David Hawkins Chelsea and Westminster Hospital Opportunities for biomedical interventions YEARS HOURS 72 HOURS YEARS Prior to exposure Exposure (pre-coital/ coital) Exposure (pre-coital/
More informationGetting Prepped for PrEP. Ken Ho, MD, MPH World AIDS Day
Getting Prepped for PrEP Ken Ho, MD, MPH World AIDS Day Objectives HIV epidemiology What is PrEP? Does it Work? Who gets PrEP? How do I prescribe PrEP What to do at the first visit? What to do at follow
More informationThe HIV Prevention Product Pipeline for Adolescents JANUARY 8 TH, 2018
The HIV Prevention Product Pipeline for Adolescents SYBIL HOSEK, PHD DEPARTMENT OF PSYCHIATRY, STROGER HOSPITAL OF COOK COUNTY I NTER-CFAR ARV FOR PREVENTION WORKING GROUP WEBINAR JANUARY 8 TH, 2018 Conflicts
More informationDominic Chow, MD, PhD, MPH, Hawaii Center for AIDS Kunane Dreier, Prevention, Life Foundation Kekoa Kealoha, Hawaii Island HIV/AIDS Foundation Alexis
Dominic Chow, MD, PhD, MPH, Hawaii Center for AIDS Kunane Dreier, Prevention, Life Foundation Kekoa Kealoha, Hawaii Island HIV/AIDS Foundation Alexis Charpentier, Harm Reduction Services Branch, Hawaii
More informationReview of planned trials and key emerging issues for Thailand
Review of planned trials and key emerging issues for Thailand Frits van Griensven, PhD, MPH Silom Community Clinic Thailand MOPH US CDC Collaboration US Centers for Disease Control and Prevention ilom
More informationPrEP and Behavioral Strategies for HIV Prevention. Douglas Krakower, MD January 30, 2014
PrEP and Behavioral Strategies for HIV Prevention Douglas Krakower, MD January 30, 2014 Potential Competing Interests Dr. Krakower: investigator-initiated research regarding HIV prevention National Institutes
More informationIs this the end of AIDS? New advances in HIV prevention. James McIntyre Anova Health Institute and University of Cape Town School of Public Health
Is this the end of AIDS? New advances in HIV prevention. James McIntyre Anova Health Institute and University of Cape Town School of Public Health Thirty years of AIDS July 3, 1981 A generation in the
More informationWHO s early release guidelines on PrEP: implications for emtct. Dominika Seidman, MD October 13, 2015
WHO s early release guidelines on PrEP: implications for emtct Dominika Seidman, MD October 13, 2015 Outline Evidence behind WHO early release guidelines on PrEP PrEP eligibility according to the WHO Rationale
More informationPre-Exposure Topical Microbicides and Oral Prophylaxis Trials:
Pre-Exposure Topical Microbicides and Oral Prophylaxis Trials: Rationale, Designs & Issues Connie Celum, MD, MPH Patrick Ndase, MBChB, MPH May 2007 Regional MTN Meeting Importance of HIV prevention Antiretroviral
More informationHIV Prevention among Women
HIV Prevention among Women Assistant Professor of Medicine Division of Infectious Diseases Baylor College of Medicine Disclosures: Gilead Sciences - Scientific Advisory Board; Investigatorinitiated research
More informationUnderstanding the Impact of an HIV Intervention Package for Adolescents
Understanding the Impact of an HIV Intervention Package for Adolescents Faikah Bruce Supervisors: Dr. Leigh Johnson (UCT - CIDER) and Prof. Alex Welte (SU - SACEMA) 1 Contents Introduction Literature Review
More informationA Field on the Verge of Change
RESEAR CH AND REALITY 9 A Field on the Verge of Change What it will take to find new prevention options for women at a unique intersection of research goals and reality. Unlike vaccine studies, which administer
More informationImpact of the Proposed Cuts to HIV/AIDS Research. Kevin Fisher AVAC September 7, 2017
Impact of the Proposed Cuts to HIV/AIDS Research Kevin Fisher AVAC September 7, 2017 President s FY18 Budget Cuts $544 m from the FY 2017 NIH HIV/AIDS research budget levels A cut of 18.5% FY 18 Cut FY
More informationThe HIV Prevention Pill: The State of PrEP Science and Implementation
The HIV Prevention Pill: The State of PrEP Science and Implementation James Wilton Coordinator, Biomedical Science of HIV Prevention CATIE December 11 th, 2014 Overview 1. The Basics 2. A review of the
More informationInternational Partnership for Microbicides
International Partnership for Microbicides Advancing HIV Prevention Options for Women GNP+ Consultation on NPTs Thomas Mertenskoetter 5. 6. July 2010, Amsterdam Leading Causes of Death in Women (Age 15
More informationHIV. The Role of Pre-Exposure Prophylaxis (PrEP) for the Prevention of HIV. Brief History of HIV AIDS. Global HIV Infection.
The Role of Pre-Exposure Prophylaxis (PrEP) for the Prevention of HIV HIV Sarah Kemink, PharmD, AAHIVP WMSHP Spring Seminar 5/05/2015 AIDS CD4 less than 200 +/- AIDS-defining illness Most common: Candidiasis
More informationWhat the Science is Saying: making the case for Treat All
What the Science is Saying: making the case for Treat All CARICOM SECRETARIAT Georgetown, Guyana July 17, 2017 Dr. Shanti Singh- Anthony Knowledge Coordinator PANCAP- Knowledge for Health Project Outline
More informationHIV Prevention: 2010
Antiretrovirals for Prevention: Opportunities and Challenges for TREAT Asia KENNETH H. MAYER, M.D. BROWN UNIVERSITY/MIRIAM HOSPITAL FENWAY HEALTH HIV Prevention: 2010 DECREASE SOURCE OF INFECTION Barrier
More informationUnderstanding the results of CAPRISA 004
A Cascade of Hope and Questions Volume 2 Understanding the results of CAPRISA 004 Key messages CAPRISA 004 provides the first proof of concept that a microbicide (1% tenofovir gel) can reduce women s risk
More informationPre-exposure Prophylaxis and Primary Care
Pre-exposure Prophylaxis and Primary Care National Latino HIV and Hepatitis C Conference June 7 th, 2016 Allison Finkenbinder, MSN, WHNP-BC Denver Prevention Training Center Who s in the audience? Disclosures
More informationWelcome and State of the Network. Cape Town, South Africa 27 th September 2016
Welcome and State of the Network Cape Town, South Africa 27 th September 2016 The HIV/AIDS Epidemic in 2016 17 million people were accessing antiretroviral therapy 36.7 million people globally were living
More informationHIV Pre-Exposure Prophylaxis (PrEP)
HIV Pre-Exposure Prophylaxis (PrEP) Disclosures No disclosures to report Carlos Malvestutto, MD, MPH Assistant Professor, Internal Medicine Division of Infectious Diseases The Ohio State University College
More informationPrEP Guidelines for the Ob/Gyn. Outline. 1. How many patient have you discussed PrEP with this year?
PrEP Guidelines for the Ob/Gyn Megan J. Huchko, MD, MPH Obstetrics and Gynecology Update October 14, 2015 I have no financial or other conflicts of interest to declare Outline The Need for PrEP: HIV Treatment
More informationMicrobicides and Antiretroviral Therapy
Microbicides and Antiretroviral Therapy Kenneth H. Mayer, M.D. Fenway Health/Beth Israel Deaconess Hospital/Harvard Medical School Infected Genital Leukocytes and Cell-Associated Virus Transmission October
More informationOn the Horizon for Consideration: Biomedical Advances in HIV Prevention
On the Horizon for Consideration: Biomedical Advances in HIV Prevention Francisco Ruiz, MS Senior Manager, National Alliance of State and Territorial AIDS Directors New Jersey Governor's Advisory Council
More informationHIV Pre-Exposure Prophylaxis (PrEP)
HIV Pre-Exposure Prophylaxis (PrEP) Carlos Malvestutto, MD, MPH Assistant Professor, Internal Medicine Division of Infectious Diseases The Ohio State University College of Medicine Disclosures No disclosures
More informationHIV Prevention. Recent Advances and Implications for the Caribbean
HIV Prevention Recent Advances and Implications for the Caribbean Chris Behrens, MD CCAS/CHART Conference Barbados, August 2010 Cases 200 180 160 140 120 100 80 60 40 20 0 Year HIV Cases AIDS Cases HIV
More informationHIV Clinical Update- HIV prevention
HIV Clinical Update- HIV prevention 18 th Australian and New Zealand Conference on Haemophilia and Rare Bleeding Disorders, Melbourne October 13 th 2017 Edwina Wright Disclosures None in the past 12 months
More informationCROI 2015: HIV Prevention Updates
NORTHWEST AIDS EDUCATION AND TRAINING CENTER CROI 2015: HIV Prevention Updates Ruanne V Barnabas, MBChB Dphil Global Health and Medicine University of Washington a bevy of new studies quelled most remaining
More informationCase Studies in PrEP Management. Kevin L. Ard, MD, MPH Massachusetts General Hospital, National LGBT Health Education Center April 15, 2016
Case Studies in PrEP Management Kevin L. Ard, MD, MPH Massachusetts General Hospital, National LGBT Health Education Center April 15, 2016 Continuing Medical Education Disclosure Program Faculty: Kevin
More informationPre-Exposure Prophylaxis (PrEP) and the Governor s Plan to End AIDS: What Every Clinician Needs to Know
Pre-Exposure Prophylaxis (PrEP) and the Governor s Plan to End AIDS: What Every Clinician Needs to Know ANTONIO E. URBINA, MD Medical Director Associate Professor of Medicine Mt. Sinai Hospital Disclosure
More informationPre-exposure prophylaxis (PrEP) in. in HIV-uninfected individuals with high-risk. behaviour
Review Pre-exposure prophylaxis (PrEP) in HIV-uninfected individuals with high-risk behaviour S. Nadery, S.E. Geerlings* Department of Internal Medicine, Infectious Diseases Division, Academic Medical
More informationPsychosocial Issues in ART and HIV Prevention. Steven A. Safren, PhD
Psychosocial Issues in ART and HIV Prevention Steven A. Safren, PhD MSM, Mental Health, and Sexual Health 1. Why is behavioral science important when using ART as prevention? 2. How can we address the
More information