Efficient T cell activation and expansion. T Cell TransAct

Size: px
Start display at page:

Download "Efficient T cell activation and expansion. T Cell TransAct"

Transcription

1 Efficient T cell activation and expansion T Cell TransAct

2 Introducing your new solution in T cell activation What is T Cell TransAct? This ready-to-use reagent provides an innovative method for physiological activation and expansion of human T cells. T Cell TransAct is a polymeric nanomatrix conjugated to humanized recombinant CD3 and CD28 agonists ensuring successful activation of resting T cells from hematological cell popu lations (e.g. PBMCs or enriched T cell populations) without the involvement of CD4 or CD8. Figure : T Cell TransAct is in suspension when added to cell culture for polyclonal T cell stimulation. MACS GMP T Cell TransAct is manufactured and controlled under ISO 3485 requirements. It is designed following the recommendations of USP <43> on ancillary materials. In the US, a master file is held with the FDA for IND applications with Certificate of Analysis available via our website. T cell activation made simple and convenient GMP Practical application Volumetric dosage Ready-to-use Removal by simple washing Robust stimulation Effector phenotype Highest cell viability Physiological and stable stimulation Convenient compatibility Available for research and GMP T cell workflows Optimized for CAR T cell production on the CliniMACS Prodigy Can be sterile filtered

3 Efficient T cell activation and expansion Effective stimulation T Cell TransAct enables optimal T cell activation with the convenience of use of a polymeric nanomatrix and is comparable to larger activation beads. Excellent proliferation Proliferation of T cells is observed after stimulation with T Cell TransAct. Equal amounts of proliferation are observed when compared to bead-based stimulation methods. CD69 + CD25 + cells (%) Proliferation (%) Negative control T Cell TransAct Competitor product Negative control T Cell TransAct Competitor product Figure 2: Comparison of activation efficiency at day 2 between T Cell TransAct and competitor product according to the activation markers CD69 and CD25. After 2 days, T Cell TransAct-activated cells are comparable to bead-activated cells. Figure 4: After 7 days, proliferation of T Cell TransAct-activated cells is equal to bead-activated cells. T cells were cultivated in TexMACS Medium supplemented with IL-7 and IL-5. High expansion When striving for robust and reliable T cell proliferation, T Cell TransAct enables serum-free T Cell cultivation while maintaining highest cell expansion. Effector phenotype Generating CAR T cells requires a stable T cell phenotype. T cells activated with T cell TransAct and subsequently expanded with IL-7 and IL-5, display a phenotype of early differentiated T cells. 5 Expansion (x-fold) Frequency of cell subset (%) Time (days) Phenotype of activated T cells Negative control T Cell TransAct Competitor product Figure 3: Comparison of T cell expansion after stimulation with T Cell TransAct or competitor product was identical in TexMACS Medium without human AB serum supplementation. Naive T cells Effector T cells Effector memory T cells Central memory T cells Stem memory T cells Figure 5: T cells were activated with T Cell TransAct and expanded for 4 days in TexMACS Medium supplemented with IL-7 and IL-5. More than 85% were stem memory T cells and central memory T cells.

4 Setting the stage for automated production of engineered T cells Optimal design for CliniMACS Prodigy MACS GMP T Cell TransAct is tailor made for the CliniMACS Prodigy. Maximum activation capacity for up to 4 billion cells vial of MACS GMP T Cell TransAct per T cell transduction (TCT) production run Cell expansion in serum-free media Clinical-scale expansion of transduced T cells is both effective under cultivation conditions with or without human AB serum (fig. 7A and B). The synergy between MACS GMP T Cell TransAct, TexMACS Medium and our MACS GMP Cytokines delivers an optimal final engineerd cell product independent of serum addition (fig. 7C). MACS GMP T Cell TransAct allows potent polyclonal T cell activation prior gene modification without the need for feeder cells. A 8 B A Lentivirus C CD3-APC-Vio77-A ³ ² ¹ - - ³ Mock control ¹ ² ³ B CD3-APC-Vio77-A D ³ ² ¹ - - ³ Gene-modified ¹ ² ³ C Cell count ( 8 ) Viability (%) Time (days) Final cell product Time (days) Retrovirus CD3-APC-Vio77-A ² ¹ - - ¹ ² ³ CD3-APC-Vio77-A ² ¹ - - ¹ ² Figure 6: Isolated T cells were activated with MACS GMP T Cell TransAct and transduced with lentivirus (A, B) or retrovirus (C, D). Transduction of T cells with GFP vector resulted in strong GFP expression days after gene modification (B, D). Transduction with mock vector shows no expression of GFP by T cells (A, C). ³ Cell percentage Serum-free NKT cells Monocytes Starting material CD8 + T cells NK cells Enriched population With serum B cells CD4 + T cells With serum TCT Granulocytes Serum-free TCT Figure 7: Enriched CD4 + and CD8 + T cells were stimulated with T Cell TransAct and expanded in a TCT process with 3% human AB serum or serum-free. Cell count (A) and viability (B) of cultured cells were measured at different time points. Cellular composition was determined in the starting material, enriched population and in the final expanded product (C).

5 Translational solutions for T cell activation Research Clinical T Cell TransAct Easy-to-use Robust T cell activation Colloidal polymeric nanomatrix ACTIVATION GMP grade Compatible with the CliniMACS Prodigy Can be sterile filtered MACS GMP T Cell TransAct MACS Cytokines High grade quality Reliable, high biological activity Flexible: customized fillings STIMULATION Superior cytokine purity High specific activity Free of animal- and humanderived materials MACS GMP Cytokines TexMACS Medium Serum-free T cell medium Specifically designed for T cell expansion Excellent quality EXPANSION Ideal for GMP compliant T cell expansion Serum- and xenocomponent free Available with or without phenol red MACS GMP TexMACS VIDEO See the CliniMACS Prodigy TCT Process in action! Generate gene-modified T cells in a simple and automated fashion. Easy to use, this unique process will surely change the way you work. miltenyibiotec.com/tct

6 Germany/Austria/ Switzerland Miltenyi Biotec GmbH Friedrich-Ebert-Straße Bergisch Gladbach Germany Phone Fax USA/Canada Miltenyi Biotec Inc. 233 Lindbergh Street Auburn, CA 9562, USA Phone 8 FOR MACS Phone Fax macs@miltenyibiotec.com Australia Miltenyi Biotec Australia Pty. Ltd. Unit 6 A, 2 Eden Park Drive Macquarie Park NSW 23 Australia Phone Fax macs@miltenyibiotec.com.au Benelux Miltenyi Biotec B.V. Schipholweg 68 H 236 XE Leiden The Netherlands macs@miltenyibiotec.nl Customer service The Netherlands Phone Fax 8 42 Customer service Belgium Phone Fax Customer service Luxembourg Phone Fax China Miltenyi Biotec Technology & Trading (Shanghai) Co., Ltd. Rooms 233 and 239 No. 39, Xianxia Road Changning District 25 Shanghai, P.R. China Phone Fax macs@miltenyibiotec.com.cn France Miltenyi Biotec SAS rue Mercoeur 75 Paris, France Phone Fax macs@miltenyibiotec.fr Italy Miltenyi Biotec S.r.l. Via Paolo Nanni Costa, Bologna Italy Phone Fax macs@miltenyibiotec.it Japan Miltenyi Biotec K.K. Nittsu-Eitai Building 5F 6- Fuyuki, Koto-ku, Tokyo 35-4, Japan Phone Fax macs@miltenyibiotec.jp Nordics and Baltics Miltenyi Biotec Norden AB Scheelevägen Lund Sweden macs@miltenyibiotec.se Customer service Sweden Phone 2-8 Fax Customer service Denmark Phone Fax Customer service Norway, Finland, Iceland, and Baltic countries Phone Fax Singapore Miltenyi Biotec Asia Pacific Pte Ltd. Beach Road #28-6 to 28-8 Shaw Tower Singapore 8972 Phone Fax macs@miltenyibiotec.com.sg South Korea Miltenyi Biotec Korea Co., Ltd Arigi Bldg. 8F 562 Nonhyeon-ro Gangnam-gu Seoul 636, South Korea Phone Fax macs@miltenyibiotec.co.kr Spain Miltenyi Biotec S.L. C/Luis Buñuel 2 Ciudad de la Imagen Pozuelo de Alarcón (Madrid) Spain Phone Fax macs@miltenyibiotec.es United Kingdom Miltenyi Biotec Ltd. Almac House, Church Lane Bisley, Surrey GU24 9DR, UK Phone Fax macs@miltenyibiotec.co.uk Miltenyi Biotec provides products and services worldwide. Visit to find your nearest Miltenyi Biotec contact. Unless otherwise specifically indicated, Miltenyi Biotec products and services are for research use only and not for therapeutic or diagnostic use. MACS GMP Products are for research use and ex vivo cell culture processing only, and are not intended for human in vivo applications. For regulatory status in the USA, please contact your local representative. MACS GMP Products are manufactured and tested under a quality management system (ISO 3485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <43> on ancillary materials. The CliniMACS System components, including Reagents, Tubing Sets, Instruments, and PBS/EDTA Buffer, are manufactured and controlled under an ISO 3485 certified quality system. All products of the CliniMACS Product Line are available for use only under an approved Investigational New Drug (IND) application. CliniMACS MicroBeads are for research use only and not for human therapeutic or diagnostic use. CliniMACS, CliniMACS Prodigy, MACS, the MACS logo, TexMACS, and TransAct are registered trademarks or trademarks of Miltenyi Biotec GmbH and/or its affiliates in various countries worldwide. Copyright 28 Miltenyi Biotec GmbH and/or its affiliates. All rights reserved

MACSxpress Technology Untouched cell isolation directly from blood products

MACSxpress Technology Untouched cell isolation directly from blood products MACSxpress Technology Untouched cell isolation directly from blood products MACSxpress Isolation Technology Fast untouched cell isolation in 25 min No density gradient centrifugation Flexible sample volumes

More information

Find the fittest MACS ART Annexin V System

Find the fittest MACS ART Annexin V System Find the fittest MACS ART Annexin V System Easy, fast, and specific depletion of unwanted apoptotic spermatozoa Improve quality of sperm preparations Obtain desired population within 30 minutes Proven

More information

Cardiovascular research solutions. Conveniently groundbreaking

Cardiovascular research solutions. Conveniently groundbreaking Cardiovascular research solutions Conveniently groundbreaking The easy workflow to pure cardiac cell types Easily dissociate neonatal hearts for the recovery of all major cardiac cell types Gentle yet

More information

Changing the way of generating engineered T cells. CliniMACS Prodigy T Cell Transduction Process

Changing the way of generating engineered T cells. CliniMACS Prodigy T Cell Transduction Process Changing the way of generating engineered T cells CliniMACS Prodigy T Cell Transduction Process CliniMACS Prodigy T Cell Transduction Process It is happening a new era of cell therapy Chimeric antigen

More information

MACS Cell Pre-Enrichment for flow sorting and analysis

MACS Cell Pre-Enrichment for flow sorting and analysis MACS Cell Pre-Enrichment for flow sorting and analysis Saves flow sorting time Improves cell viability Enhances quality of flow cytometry data MACS Cell Pre-Enrichment for flow sorting Time-saving cell

More information

Clinical research Treg cell manufacture CliniMACS Cell Separation System and MACS GMP Products

Clinical research Treg cell manufacture CliniMACS Cell Separation System and MACS GMP Products Clinical research Treg cell manufacture CliniMACS Cell Separation System and MACS GMP Products Treg cell enrichment and depletion MACS GMP Fluorescent Antibodies for flow sorting Treg cell expansion Analysis

More information

The broadest portfolio for your innate lymphoid cell research

The broadest portfolio for your innate lymphoid cell research The broadest portfolio for your innate lymphoid cell research Tissue dissociation Cell separation Cell culture Flow cytometry Innate lymphoid cells Overview Innate lymphoid cells comprise various subpopulations

More information

Regulatory T cell research

Regulatory T cell research Regulatory T cell research Unique kits for cell isolation Harmonized cell culture and expansion tools Convenient functional assay tools Reliable flow cytometry analysis Introduction The complete workflow

More information

CliniMACS Technology in stem cell transplantation

CliniMACS Technology in stem cell transplantation Advancing clinical applications CliniMACS Technology in stem cell transplantation Graft manipulation T cell and B cell depletion Balance of GvT versus GvHD Fighting infections CliniMACS Technology in stem

More information

The broadest portfolio for your T cell research

The broadest portfolio for your T cell research quick guide The broadest portfolio for your T cell research Sample preparation Cell separation Cell culture Flow cytometry Mouse T cells Overview CD4 + T cell subsets Polarization reagents Naive CD4 +

More information

All you need for your T cell research

All you need for your T cell research All you need for your T cell research Gentle sample preparation Accurate cell separation Optimized cell culture Precise flow cytometry Products for isolation of mouse T cells T cells CD3ε MicroBead Kit

More information

Myocardial regeneration autologous stem cell therapy

Myocardial regeneration autologous stem cell therapy Myocardial regeneration autologous stem cell therapy 1 SPL/Agentur Focus Index Main patient cohort 3 Introduction 3 Cell therapy using adult, autologous stem cells 5 Clinical study results 6 Methodology

More information

MACS Marker Screen. MACS Marker Screen. Catalog antibodies. antibodies CD4 (VIT4) CD11b. MACS Marker Screen antibodies. Catalog. antibodies CD2 CD14

MACS Marker Screen. MACS Marker Screen. Catalog antibodies. antibodies CD4 (VIT4) CD11b. MACS Marker Screen antibodies. Catalog. antibodies CD2 CD14 MACS Marker Screen The performance of MACS Marker Screen was tested and compared with catalog reagents offered in single vials as liquid antibody reagents. The were reconstituted using 25 µl of deionized

More information

IFN-γ Secretion Assay Detection Kit (PE) human

IFN-γ Secretion Assay Detection Kit (PE) human Miltenyi Biotec GmbH Friedrich-Ebert-Straße 68 51429 Bergisch Gladbach, Germany Phone +49 2204 8306-0 Fax +49 2204 85197 macs@miltenyibiotec.de Miltenyi Biotec Inc. 12740 Earhart Avenue Auburn CA 95602,

More information

Isn t it worth two bags?

Isn t it worth two bags? Isn t it worth two bags? NEW from Miltenyi Biotec CryoMACS Freezing Bag CryoMACS Freezing Bag Designed for freezing and cryopreservation of blood components Overwrap bag protects both sample and freezing

More information

Automated manufacture of T-cell immunotherapies using gamma retroviral transduction. Lee Markwick, PhD. AMC, Manchester March 2018

Automated manufacture of T-cell immunotherapies using gamma retroviral transduction. Lee Markwick, PhD. AMC, Manchester March 2018 Automated manufacture of T-cell immunotherapies using gamma retroviral transduction Lee Markwick, PhD AMC, Manchester March 2018 Automated generation of CAR T cells Starting material d0 T cell enrichment

More information

In vitro human regulatory T cell expansion

In vitro human regulatory T cell expansion - 1 - Human CD4 + CD25 + regulatory T cell isolation, Workflow in vitro expansion and analysis In vitro human regulatory T cell expansion Introduction Regulatory T (Treg) cells are a subpopulation of T

More information

In vitro human regulatory T cell expansion

In vitro human regulatory T cell expansion - 1 - Human CD4 + CD25 + CD127 dim/- regulatory T cell Workflow isolation, in vitro expansion and analysis In vitro human regulatory T cell expansion Introduction Regulatory T (Treg) cells are a subpopulation

More information

Simple automated manufacturing of gene engineered T cells from lymphoma and melanoma blood samples

Simple automated manufacturing of gene engineered T cells from lymphoma and melanoma blood samples Simple automated manufacturing of gene engineered T cells from lymphoma and melanoma blood samples ISCT North America 216 Regional Meeting Nadine Mockel-Tenbrinck Miltenyi Biotec GmbH Macrophage Tumour

More information

PRIME-XV Dendritic Cell Maturation CDM

PRIME-XV Dendritic Cell Maturation CDM PRIME-XV Dendritic Cell Maturation CDM Chemically defined, animal component-free medium for dendritic cell culture Optimized for differentiation of monocytes into immature dendritic cells (idcs) and subsequent

More information

Bio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c. VARIANT II TURBO Link. Fully-Automated HbA 1c Testing

Bio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c. VARIANT II TURBO Link. Fully-Automated HbA 1c Testing Bio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c VARIANT II TURBO Link Fully-Automated HbA 1c Testing Bio-Rad Laboratories HEMOGLOBIN Testing VARIANT II TURBO Link Efficient streamlined process Powerful

More information

Direct ex vivo characterization of human antigen-specific CD154 + CD4 + T cells Rapid antigen-reactive T cell enrichment (Rapid ARTE)

Direct ex vivo characterization of human antigen-specific CD154 + CD4 + T cells Rapid antigen-reactive T cell enrichment (Rapid ARTE) Direct ex vivo characterization of human antigen-specific CD154 + CD4 + T cells Rapid antigen-reactive T cell enrichment (Rapid ARTE) Introduction Workflow Antigen (ag)-specific T cells play a central

More information

Bio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c. VARIANT II TURBO Link System. Fully-Automated HbA 1c Testing

Bio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c. VARIANT II TURBO Link System. Fully-Automated HbA 1c Testing Bio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c VARIANT II TURBO Link System Fully-Automated HbA 1c Testing Bio-Rad Laboratories HEMOGLOBIN Testing VARIANT II TURBO Link System Efficient streamlined

More information

The first and only fully-automated, multiplexed solution for Measles, Mumps, Rubella and Varicella-zoster virus antibody testing

The first and only fully-automated, multiplexed solution for Measles, Mumps, Rubella and Varicella-zoster virus antibody testing Bio-Rad Laboratories BioPlex 2200 System BioPlex 2200 MMRV IgG Kit The first and only fully-automated, multiplexed solution for Measles, Mumps, Rubella and Varicella-zoster virus antibody testing Bio-Rad

More information

In vitro human regulatory T cell suppression assay

In vitro human regulatory T cell suppression assay Human CD4 + CD25 + regulatory T cell isolation, in vitro suppression assay and analysis In vitro human regulatory T cell suppression assay Introduction Regulatory T (Treg) cells are a subpopulation of

More information

Type 1 Diabetes Australian Research Impact Analysis

Type 1 Diabetes Australian Research Impact Analysis Type 1 Diabetes Australian Research Impact Analysis Executive Overview Summary Type 1 diabetes research in Australia Australia is making a significant contribution to the quantity and quality of the global

More information

90 min 18 min. 45 min. 14 d

90 min 18 min. 45 min. 14 d Isolation, cultivation, and expansion of Pan T cells from human PBMCs In vitro expansion of human Pan T cells Introduction T lymphocytes (T cells) play a central role in the adaptive immune system by controlling

More information

Bio-Rad Laboratories. Hemoglobin Testing. VARIANT II Hemoglobin Testing System For HbA 1c

Bio-Rad Laboratories. Hemoglobin Testing. VARIANT II Hemoglobin Testing System For HbA 1c Bio-Rad Laboratories Hemoglobin Testing VARIANT II Hemoglobin Testing System For HbA 1c Bio-Rad CDM System CDM 5.1 VII Instrument Patient Report V2_A1c_NU Patient Data Sample ID: AD Patient ID: Name: Physician:

More information

Results you can trust

Results you can trust PRODUCT I NF OR MAT ION pharmdx Results you can trust The first and only FDA-approved PD-L1 test to assess the magnitude of treatment effect on progression-free survival in melanoma patients from OPDIVO

More information

Hand Hygiene in Focus. MICROSHIELD Product Catalogue

Hand Hygiene in Focus. MICROSHIELD Product Catalogue Hand Hygiene in Focus. MICROSHIELD Product Catalogue In the everyday business of healthcare, no instrument is more in focus than the human hand. From what we know today, our hands represent the greatest

More information

Chemical compatibility of the Pall QPoint TM Docking Station - Tap Assembly with common surface disinfectants

Chemical compatibility of the Pall QPoint TM Docking Station - Tap Assembly with common surface disinfectants Technical Report.78a Chemical compatibility of the Pall QPoint TM - Tap Assembly with common surface disinfectants QPoint - More than Filtration .0 Background The Pall QPoint Tap Water Filter Assembly

More information

Immunohematology. IH-QC Modular System. Select. Combine. Control.

Immunohematology. IH-QC Modular System. Select. Combine. Control. Immunohematology IH-QC Modular System Select. Combine. Control. IH-QC Modular System Select. Combine. Control. Transfusion guidelines recommend regular checking of test materials, test methods, local working

More information

Cardiac Assessment Controls

Cardiac Assessment Controls Bio-Rad Laboratories CARDIAC ASSESSMENT CONTROLS Cardiac Assessment Controls Value Assigned for Clinical Laboratory and Point of Care Test Systems Solving the Challenges of Troponin I Testing for the Central

More information

Maxwell Technologies, Inc. Global Headquarters 3888 Calle Fortunada San Diego, CA USA Phone: +1 (858) Fax: +1 (858)

Maxwell Technologies, Inc. Global Headquarters 3888 Calle Fortunada San Diego, CA USA Phone: +1 (858) Fax: +1 (858) TECHNICAL BULLETIN Engine Start Module (ESM) Functional Test Rev 2. Maxwell Technologies, Inc. February 2017 Maxwell Technologies, Inc. Global Headquarters 3888 Calle Fortunada San Diego, CA 92123 USA

More information

Infectious Disease Testing. ULTRA Product Line. Safety is not a Matter of Chance

Infectious Disease Testing. ULTRA Product Line. Safety is not a Matter of Chance Infectious Disease Testing ULTRA Product Line Safety is not a Matter of Chance ULTRA Product Line The best answer for HBV, HCV and HIV screening: a global automated solution for safe results. Monolisa

More information

PRODUCT INFORMATION. New Reagents for Dako CoverStainer. Choose the H&E staining intensity you want.

PRODUCT INFORMATION. New Reagents for Dako CoverStainer. Choose the H&E staining intensity you want. PRODUCT INFORMATION Primary Staining Dako CoverStainer Reagents New Reagents for Dako CoverStainer. Choose the H&E staining intensity you want. New flexible staining intensities to fit y Dako H&E Staining

More information

NobelProcera Implant Bar Overdenture complete range of fixed and removable solutions.

NobelProcera Implant Bar Overdenture complete range of fixed and removable solutions. NobelProcera Implant Bar Overdenture EXPERIENCE THE NEW WORLD OF CAD/CAM DENTISTRY 2 NobelProcera Implant Bar Overdenture NobelProcera Implant Bar Overdenture complete range of fixed and removable solutions.

More information

BioPlex 2200 Infectious Disease Panels

BioPlex 2200 Infectious Disease Panels BioPlex 2200 System BioPlex 2200 Infectious Disease Panels An Expanding Multiplexed Assay Menu Lyme HIV Ag-Ab MMV IgM Syphilis Total & RPR MMRV EBV HSV-1 & HSV-2 EBV IgM ToRC IgM ToRC Leading the way with

More information

POWERFUL PERSPECTIVES

POWERFUL PERSPECTIVES POWERFUL PERSPECTIVES SUPREMIA Developing New Perspectives Sounds are important to all of us, but for children they are indispensable for their auditory and cognitive development. As a parent, you would

More information

Radiotherapy and Radiosurgery

Radiotherapy and Radiosurgery RapidArc Radiotherapy and Radiosurgery RapidArc Faster. Sharper. Smarter. * It s true for the latest generation of RapidArc technology, and it can be true for your clinic. The oncology landscape has shifted

More information

Third Party Controls for Your Dade Behring Systems

Third Party Controls for Your Dade Behring Systems Bio-Rad Laboratories Q U A L I T Y C O N T R O L Third Party Controls for Your Dade Behring Systems The Complete QC Solution from Bio-Rad Laboratories Bio-Rad has the control you need for your Dade Behring

More information

Fast and Easy Isolation of T Cells

Fast and Easy Isolation of T Cells Fast and Easy Isolation of T Cells Isolate T Cells In As Little As 25 Minutes Isolate whole T cell populations as well as various T cell subsets with high purity and recovery using the fast and easy T

More information

Request for Letters of Intent. International Development of H5N1 Influenza Vaccines

Request for Letters of Intent. International Development of H5N1 Influenza Vaccines Request for Letters of Intent International Development of H5N1 Influenza Vaccines The World Health Organization (WHO) intends to provide funding to developing (1) country vaccine manufacturers to develop

More information

PRODUCT DECLARATION. Purolite C100MRNS. This declaration was prepared by Purolite Corporation in February, 2017.

PRODUCT DECLARATION. Purolite C100MRNS. This declaration was prepared by Purolite Corporation in February, 2017. PRODUCT DECLARATION Purolite C100MRNS This declaration was prepared by Purolite Corporation in February, 2017. Prepared by: Doina Florea Quality & Regulatory Manager Cosmin Catanas Quality Assurance Engineer

More information

Navigate Complex Interventions at Every Turn

Navigate Complex Interventions at Every Turn Navigate Complex Interventions at Every Turn Keep Driving Forward The portfolio of Catheters places the power in your hands. Navigate tortuous anatomy with agility and precision. No matter the challenge,

More information

For personal use only

For personal use only Sirtex Medical Limited (ASX:SRX) Macquarie Inaugural Annual Emerging Healthcare Conference Mr Gilman Wong, CEO Mr Darren Smith, CFO Dr David Cade, CMO Wednesday, 10 October 2012 Macquarie Securities Group

More information

Cardiac Assessment Controls A critical element of reliable cardiac testing

Cardiac Assessment Controls A critical element of reliable cardiac testing Cardiac Assessment Controls Cardiac Assessment Controls A critical element of reliable cardiac testing Choose the products best suited for your cardiac assessment needs Each year, 17.7 million people on

More information

VARIAN ONCOLOGY. RapidArc. One revolution is all it takes.

VARIAN ONCOLOGY. RapidArc. One revolution is all it takes. VARIAN ONCOLOGY RapidArc. One revolution is all it takes. Previous approaches to arc IMRT therapy have been restrictive. Some are limited by machine design, and deliver treatments in the axial plane only,

More information

Arrow-Clark VectorFlow Hemodialysis Catheter Because in Chronic Hemodialysis Catheters, the Tip Matters

Arrow-Clark VectorFlow Hemodialysis Catheter Because in Chronic Hemodialysis Catheters, the Tip Matters Arrow-Clark VectorFlow Hemodialysis Catheter Because in Chronic Hemodialysis Catheters, the Tip Matters Because in chronic hemodialysis catheters, the tip matters Designed for Performance Tip design optimizes

More information

Free Trial Future Generics Database

Free Trial Future Generics Database API Atazanavir Structure O 2 C N H O H N OH N NH O N H N CO2 Brand REYATAZ (BMS : World) Indication Antiviral Originator Ciba-Geigy (Novartis) Developer / Licensee BMS Comments Atazanavir is an azapeptide

More information

Introducing the TrueBeam STx system with Novalis Radiosurgery.

Introducing the TrueBeam STx system with Novalis Radiosurgery. Introducing the TrueBeam STx system with Novalis Radiosurgery. For the best minds in radiosurgery. TrueBeam STx with Novalis Radiosurgery. As radical as the best minds in radiosurgery, the TrueBeam STx

More information

ISCT Workshop #7 Perspectives in Cell Selection Immunomagnetic Selection

ISCT Workshop #7 Perspectives in Cell Selection Immunomagnetic Selection ISCT Workshop #7 Perspectives in Cell Selection Immunomagnetic Selection Carolyn A. Keever-Taylor, PhD Medical College of Wisconsin June 7, 2012 History of Available Devices CellPro CEPRATE Avidin/Biotin

More information

PyroMark Q24 CpG MGMT Handbook

PyroMark Q24 CpG MGMT Handbook December 2009 PyroMark Q24 CpG MGMT Handbook For quantification of CpG methylation in region +17 to +39 in the MGMT gene Sample & Assay Technologies QIAGEN Sample and Assay Technologies QIAGEN is the leading

More information

508 the number of suicide deaths in deaths per 100,000 people was the suicide rate in Suicide deaths in 2013 by gender

508 the number of suicide deaths in deaths per 100,000 people was the suicide rate in Suicide deaths in 2013 by gender An overview of suicide statistics This document summarises information about suicide deaths in New Zealand covering up to 13. It does not attempt to explain causes of suicidal behaviour or causes of changes

More information

ISO INTERNATIONAL STANDARD. Non-destructive testing Penetrant testing Part 1: General principles

ISO INTERNATIONAL STANDARD. Non-destructive testing Penetrant testing Part 1: General principles INTERNATIONAL STANDARD ISO 3452-1 First edition 2008-09-01 Non-destructive testing Penetrant testing Part 1: General principles Essais non destructifs Examen par ressuage Partie 1: Principes généraux Reference

More information

FUNCTIONAL TRAINING SOLUTIONS

FUNCTIONAL TRAINING SOLUTIONS FUNCTIONAL TRAINING SOLUTIONS FUNCTIONAL TRAINING SOLUTIONS Increase member loyalty, engagement and generate additional revenues. We ll help you build a complete Functional Training solution that meets

More information

PRODUCT DECLARATION. Purolite A430MR. This declaration was prepared by Purolite Corporation in February, 2017.

PRODUCT DECLARATION. Purolite A430MR. This declaration was prepared by Purolite Corporation in February, 2017. PRODUCT DECLARATION Purolite A430MR This declaration was prepared by Purolite Corporation in February, 2017. Prepared by: Doina Florea Quality & Regulatory Manager Cosmin Catanas Quality Assurance Engineer

More information

Bio-Rad Laboratories. Cardiac Assessment Controls. Value Assigned for Clinical Laboratory and Point of Care Test Systems

Bio-Rad Laboratories. Cardiac Assessment Controls. Value Assigned for Clinical Laboratory and Point of Care Test Systems Bio-Rad Laboratories Cardiac Assessment Controls Cardiac Assessment Controls Value Assigned for Clinical Laboratory and Point of Care Test Systems Solving the Challenges of Troponin I Testing for the Central

More information

PRODUCT DECLARATION. Purolite C115KMR. This declaration was prepared by Purolite Corporation in February, 2017.

PRODUCT DECLARATION. Purolite C115KMR. This declaration was prepared by Purolite Corporation in February, 2017. PRODUCT DECLARATION Purolite C115KMR This declaration was prepared by Purolite Corporation in February, 2017. Prepared by: Doina Florea Quality & Regulatory Manager Cosmin Catanas Quality Assurance Engineer

More information

ZEODENT. High performing dental silicas. Engineered to Deliver Exceptional Performance and Formulating Flexibility

ZEODENT. High performing dental silicas. Engineered to Deliver Exceptional Performance and Formulating Flexibility ZEODENT High performing dental silicas Engineered to Deliver Exceptional Performance and Formulating Flexibility THE TRUSTED AND RELIABLE SOURCE FOR DENTAL SILICAS * Hamina, Finland Oostende, Belgium Etowah,

More information

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle   holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/23854 holds various files of this Leiden University dissertation. Author: Marel, Sander van der Title: Gene and cell therapy based treatment strategies

More information

Pala Mix & Match DS Artificial teeth for CAD/CAM process

Pala Mix & Match DS Artificial teeth for CAD/CAM process Pala Mix & Match DS Artificial teeth for CAD/CAM process Giving a hand to oral health. Product info Bringing together classic and digital dental technology With Pala Mix & Match DS When teeth are adjusted

More information

artus EBV QS-RGQ Kit Performance Characteristics May 2012 Sample & Assay Technologies Analytical sensitivity plasma

artus EBV QS-RGQ Kit Performance Characteristics May 2012 Sample & Assay Technologies Analytical sensitivity plasma artus EBV QS-RGQ Kit Performance Characteristics artus EBV QS-RGQ Kit, Version 1, 4501363 Check availability of new electronic labeling revisions at www.qiagen.com/products/artusebvpcrkitce.aspx before

More information

Thermo Scientific Finntip Pipette Tips. HANDHELD PIPETTING Finntip Pipette Tips. Details

Thermo Scientific Finntip Pipette Tips. HANDHELD PIPETTING Finntip Pipette Tips. Details Thermo Scientific Finntip Pipette Tips Finntip* pipette tips are manufactured using high quality materials and the latest molding techniques for proven reliability. Thermo Scientific Finntip pipette tips

More information

ab Exosome Isolation and Analysis Kit - Flow Cytometry, Plasma

ab Exosome Isolation and Analysis Kit - Flow Cytometry, Plasma Version 1 Last updated 25 May 2018 ab228565 Exosome Isolation and Analysis Kit - Flow Cytometry, Plasma For the isolation/detection of exosomes from human plasma, urine or cell culture media. This product

More information

ab Exosome Isolation and Analysis Kit - Flow Cytometry, Cell culture

ab Exosome Isolation and Analysis Kit - Flow Cytometry, Cell culture Version 1 Last updated 14 March 2018 ab228564 Exosome Isolation and Analysis Kit - Flow Cytometry, Cell culture For the measurement of human exosomes in cell culture. This product is for research use only

More information

DIFFERENT NEEDS...YOUR GLOBAL SOLUTION. Specification Guide. Hip Knee Spine Navigation

DIFFERENT NEEDS...YOUR GLOBAL SOLUTION. Specification Guide. Hip Knee Spine Navigation M E D I A L L Y S T A B I L I Z E D K N E E DIFFERENT NEEDS......YOUR GLOBAL SOLUTION Specification Guide Hip Knee Spine Navigation GMK SPHERE Surgical Technique Hip Knee Spine Navigation GMK SPHERE -

More information

Schedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK

Schedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK ISO/IEC 17021-1:2015 to provide quality management systems Davy Avenue Knowhill Milton Keynes MK5 8NL Contact: Dr Eugene Kotlirov Tel: +44

More information

TECHNICAL BULLETIN. Engine Start Module (ESM) Functional Test. Maxwell Technologies, Inc. June

TECHNICAL BULLETIN. Engine Start Module (ESM) Functional Test. Maxwell Technologies, Inc. June TECHNICAL BULLETIN (ESM) Functional Test Technologies, Inc. June 2015 Technologies, Inc. Global Headquarters 3888 Calle Fortunada San Diego, CA 92123 USA Phone: +1 (858) 503-3300 Fax: +1 (858) 503-3301

More information

Ordering Information. ProteOn XPR36 System. Protein Interaction Analysis

Ordering Information. ProteOn XPR36 System. Protein Interaction Analysis Protein Interaction Analysis Ordering Information ProteOn XPR36 System The ProteOn XPR36 system is an optical biosensor capable of simultaneously measuring 36 individual molecular interactions. It integrates

More information

for therapeutic drug monitoring

for therapeutic drug monitoring Thermo Scientific TDM Assays for Therapeutic Drug Monitoring Complete solutions for therapeutic drug monitoring TDM tests provide quantitative results to ensure beneficial therapeutic effects by determining

More information

Arrow Cannon II Plus Retrograde-tunneled, Tip-first Chronic Hemodialysis Catheter

Arrow Cannon II Plus Retrograde-tunneled, Tip-first Chronic Hemodialysis Catheter Arrow Cannon II Plus Retrograde-tunneled, Tip-first Chronic Hemodialysis Catheter Arrow Cannon II Plus Optimal Placement, Minimal Risk. The Tip-first Advantage Start at the Heart with Arrow Cannon II Plus

More information

by EUA Denmark Italy Portugal Israel Canada Finland Luxembourg Spain Australia Mexico France Monaco Sweden China Austria Germany Netherlands Switzerland Japan Belgium Ireland Norway United Kingdom South

More information

Terms and Conditions. VISA Global Customer Assistance Services

Terms and Conditions. VISA Global Customer Assistance Services Terms and Conditions VISA Global Customer Assistance Services Visa Global Customer Assistance Services (VGCAS) 1 The Visa Global Customer Assistance Services are co-ordinated by the Global Assistance Centre

More information

SUPPORT READY, SET, GO! A guide for travelling with your Cochlear implant

SUPPORT READY, SET, GO! A guide for travelling with your Cochlear implant SUPPORT A+ READY, SET, GO! A guide for travelling with your Cochlear implant READY, SET, GO! A guide for travelling with your Cochlear implant Travelling with a Cochlear implant can be easy but it s important

More information

Instant Quality FISH. The name says it all.

Instant Quality FISH. The name says it all. PRODUCT INFORMATION HER2 IQFISH pharmdx Instant Quality FISH Instant Quality FISH. The name says it all. HER2 IQFISH pharmdx IQ: Instant Quality every time. HER2 IQFISH pharmdx stains of a HER2 non-amplified

More information

Thermo Scientific Finnpipette Manual Pipetting Systems. you can handle. anything

Thermo Scientific Finnpipette Manual Pipetting Systems. you can handle. anything Thermo Scientific Manual Pipetting Systems you can handle anything Leader in Pipetting Technology Since the introduction of the first variable volume micropipette in 1971, more than four million Thermo

More information

WESTERN EUROPE PREVALENCE AND INCIDENCE OF PERIPHERAL ARTERY DISEASE AND CRITICAL LIMB ISCHEMIA 2017

WESTERN EUROPE PREVALENCE AND INCIDENCE OF PERIPHERAL ARTERY DISEASE AND CRITICAL LIMB ISCHEMIA 2017 WESTERN EUROPE PREVALENCE AND INCIDENCE OF PERIPHERAL ARTERY DISEASE AND CRITICAL LIMB ISCHEMIA 2017 Mary L. Yost 404-520-6652 , LLC 23 Ridge Rd. Beaufort, SC 20097 Copyright Pending 2017 All rights reserved,

More information

THE ISSUE. How will this situation adversely impact on the consumer, trade and the future acceptance of TCM?

THE ISSUE. How will this situation adversely impact on the consumer, trade and the future acceptance of TCM? THE ISSUE The use of TCM is expanding rapidly across the world yet, in many countries, there is little or no quality control around the products or practitioners. How will this situation adversely impact

More information

ab Exosome Isolation and Analysis Kit - Flow Cytometry, Cell Culture (CD63 / CD81)

ab Exosome Isolation and Analysis Kit - Flow Cytometry, Cell Culture (CD63 / CD81) Version 1 Last updated 26 September 2018 ab239682 Exosome Isolation and Analysis Kit - Flow Cytometry, Cell Culture (CD63 / For the isolation and analysis of exosome from cell culture. This product is

More information

ab Cell Invasion Assay (Basement Membrane), 24-well, 8 µm

ab Cell Invasion Assay (Basement Membrane), 24-well, 8 µm Version 1 Last updated 29 June 2018 ab235882 Cell Invasion Assay (Basement Membrane), 24-well, 8 µm For the measurement of cell invasion in response to stimuli. This product is for research use only and

More information

For research or further manufacturing use only. Not for injection or diagnostic procedures.

For research or further manufacturing use only. Not for injection or diagnostic procedures. PRIME-XV T cell Expansion XSFM PRIME-XV T Cell Expansion XSFM is a xeno-free, serum-free medium optimized for the activation and expansion of human T lymphocytes. This medium contains gentamicin and requires

More information

Why Choose OriGen? Mission Statement: We create medical products which improve peoples lives.

Why Choose OriGen? Mission Statement: We create medical products which improve peoples lives. Accessory Catalog S-FFP12 Mission Statement: We create medical products which improve peoples lives. Why Choose OriGen? Quality Commitment quality is the foundation of all product design at OriGen, and

More information

HER2 FISH pharmdx TM Interpretation Guide - Breast Cancer

HER2 FISH pharmdx TM Interpretation Guide - Breast Cancer P A T H O L O G Y HER2 FISH pharmdx TM Interpretation Guide - Breast Cancer For In Vitro Diagnostic Use FDA approved as an aid in the assessment of patients for whom Herceptin TM (trastuzumab) treatment

More information

In-Use Evaluation Report

In-Use Evaluation Report In-Use Evaluation Report 160127.3WIN Pall QPoint TM Shower Water Filter Assembly Reusable Docking Station - Shower Assembly (QDS) and Disposable Filter Capsule for up to 62 Day Use - Shower (QR212 and

More information

Productivity in Real-time

Productivity in Real-time Productivity in Real-time WITH Maximizing the efficiency of ultrasound scanning Processing Technology Pulser Enhanced Diagnostic Value Maximizing Signal Information Low power consumption More efficient

More information

OPENING UP A NEW WORLD

OPENING UP A NEW WORLD OPENING UP A NEW WORLD www.bernafon.com WELCOME TO THE WORLD OF BERNAFON We are a Swiss brand and company that people can rely on and trust. At Bernafon, we are passionate about developing stateof-the-art,

More information

The OECD Health Care Quality Indicators Project

The OECD Health Care Quality Indicators Project The OECD Health Care Quality Indicators Project Ed Kelley, Ph.D. Head, OECD Health Care Quality Indicators Project Health Systems Working Party Luxembourg - April 26, 2005 1 Broad aims of the OECD s HCQI

More information

NobelProcera Implant Bar Overdenture EXPERIENCE THE NEW WORLD OF CAD/CAM DENTISTRY

NobelProcera Implant Bar Overdenture EXPERIENCE THE NEW WORLD OF CAD/CAM DENTISTRY NobelProcera Implant Bar Overdenture EXPERIENCE THE NEW WORLD OF CAD/CAM DENTISTRY 2 NobelProcera Implant Bar Overdenture NobelProcera Implant Bar Overdenture complete range of fixed and removable solutions.

More information

Calibration Solutions. be certain.

Calibration Solutions. be certain. Calibration Solutions be certain. MTS CALIBRATION SERVICES Optimize THE VALIDITY OF YOUR TEST DATA AND THE EFFICIENCY OF YOUR TEST LAB. OUR ACCREDITED ONSITE CALIBRATION AND METROLOGY LABORATORY; As well

More information

WCPT COUNTRY PROFILE December 2017 SWEDEN

WCPT COUNTRY PROFILE December 2017 SWEDEN WCPT COUNTRY PROFILE December 2017 SWEDEN SWEDEN NUMBERS WCPT Members Practising physical therapists 11,043 Total number of physical therapist members in your member organisation 17,906 Total number of

More information

Louisville '19 Attachment #69

Louisville '19 Attachment #69 Telephone Meeting Approved and why I propose Using zoom to fulfill both Phone and Virtual video meeting Formats. The first established phone meeting Sanctioned by Gamblers Anonymous (listed on Trustee

More information

ACCESS + NAVIGATION + STABILIZATION

ACCESS + NAVIGATION + STABILIZATION ACCESS + NAVIGATION + STABILIZATION Merit Medical s intuitive platform is designed to treat vertebral compressions fractures, and can provide rapid and lasting pain relief 1 with the most advanced targeted

More information

TGX and TGX Stain-Free FastCast Acrylamide Kits

TGX and TGX Stain-Free FastCast Acrylamide Kits Electrophoresis TGX and TGX Stain-Free FastCast Acrylamide Kits The newest frontier for handcast gels It s Time to Expect More from Handcast Gels! FastCast kits provide unparalleled convenience and performance.

More information