MEETING PROSPECTUS. HIV CLINICAL FORUM INTEGRASE INHIBITORS DURBAN, SOUTH AFRICA 16 July 2016

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EDUCATION BILTSTRAAT 106 3572 BJ UTRECHT THE NETHERLANDS

1 MEETING PROSPECTUS HIV CLINICAL FORUM INTEGRASE INHIBITORS DURBAN, SOUTH AFRICA 16 July 2016 VIROLOGY EDUCATION BILTSTRAAT BJ UTRECHT THE NETHERLANDS

2 CONTENTS INTRODUCTION... 3 INTEGRASE INHIBITORS... 3 VIROLOGY EDUCATION... 3 CONTACT INFORMATION... 4 HIV CLINICAL FORUM... 5 PROGRAM DESCRIPTION... 5 First HIV CLINICAL FORUM on INTEGRASE INHIBITORS... 5 MEETING RESULTS... 6 HIV CLINICAL FORUM WEBSITE... 6 MISSION... 7 GLOBAL HIV CLINICAL FORUM ON INTEGRASE INHIBITORS - DURBAN, SOUTH AFRICA 16 JULY PROGRAM CHAIRS... 8 SCIENTIFIC COMMITTEE... 8 FACULTY LEARNING OBJECTIVES ENDORSEMENT ACCREDITATION FORMAT & LOCATION PRELIMINARY PROGRAM GLOBAL HIV CLINICAL FORUM REQUEST FOR SUPPORT

INTRODUCTION INTEGRASE INHIBITORS With the introduction of Integrase Inhibitors a new promising class of drugs has become available which promises to impact greatly the daily management of HIV.

It is essential to prepare the medical community extensively on how to best integrate this class of drugs into daily clinical management in order to ensure best treatment for HIV infected patients.

Based on the success of this program, it is our pleasure to submit for your evaluation a request for support for the Global HIV CLINICAL FORUM on Integrase Inhibitors that will take place prior to

3 INTRODUCTION INTEGRASE INHIBITORS With the introduction of Integrase Inhibitors a new promising class of drugs has become available which promises to impact greatly the daily management of HIV. Already Integrase is identified as first line treatment in several countries and many other countries will follow in the (near) future. It is essential to prepare the medical community extensively on how to best integrate this class of drugs into daily clinical management in order to ensure best treatment for HIV infected patients. On October 20th, 2015, we organized the first in a series of HIV CLINICAL FORUM meetings dedicated to the integration of science and clinical practice, which focused entirely on Integrase Inhibitors. Based on the success of this program, it is our pleasure to submit for your evaluation a request for support for the Global HIV CLINICAL FORUM on Integrase Inhibitors that will take place prior to the AIDS 2016 Conference in Durban, South Africa on July 16 th, VIROLOGY EDUCATION Our organization has over 15 years of experience and expertise in the initiation and organization of state-of- the-art educational programs in the field of virology. We have cultivated a long-standing collaboration with the most prominent key opinion leaders, facilitating our development of high profile educational events specifically tailored to the needs of HIV treating healthcare professionals. 3

4 CONTACT INFORMATION If you have any questions about this proposal, please contact: Alice Posthumus-Plantinga Managing Director Phone: alice.posthumus-plantinga@vironet.com 4

HIV CLINICAL FORUM background of the participants: PROGRAM DESCRIPTION The HIV CLINICAL FORUM is developed as part of a series of interactive programs that provide Nurse Pharmacist/P harmacologis t

5 HIV CLINICAL FORUM background of the participants: PROGRAM DESCRIPTION The HIV CLINICAL FORUM is developed as part of a series of interactive programs that provide Nurse Pharmacist/P harmacologis t 4% 2% Other 13% Researcher 15% Medical doctor 66% independent medical education on emerging topics in HIV. The program features Key Opinion Leaders in order to provide HIV clinicians and allied healthcare professionals with updates on the latest developments related to HIV management, providing opportunities for sharing of clinical experience and presenting results from ongoing and completed cohorts / research programs. Furthermore, the HIV CLINICAL FORUM encourages skills building for optimal interpretation of research results, developing collaborations and initiating research projects. The state-of-the-art program provided challenging plenary lectures followed by ample time for Q&A and debate, stimulating interaction and bridging the knowledge gap between experts and the HIV treating community. Additionally, the program included parallel skills building sessions followed by a session where the medical community shared their clinical experience by presenting and discussing clinical cases. The program was deliberately scheduled prior to EACS in order to allow healthcare professionals to combine both meetings in one trip, thus limiting travel time and the number of days away from the FIRST HIV CLINICAL FORUM ON INTEGRASE INHIBITORS The first HIV CLINICAL FORUM on Integrase Inhibitors was organized on 20 October 2015, prior to EACS in Barcelona Spain. This abstractdriven program was attended by 127 clinicians clinic. A component that contributed significantly to the success of this program was the possibility to provide conference participation grants to healthcare professionals by our organization. from 22 countries who submitted 22 abstracts. Please find herewith an overview of the 5

6 MEETING RESULTS We performed an extensive evaluation of the program in order to measure the impact. Neutral 9% Strongly agree/agree 91% Disagree/stro ngly disagree 0% Participants were asked to rate the extent to which they agreed to the quotes below (5=strongly agree 1= strongly disagree). Please find herewith some results: The lectures increased my knowledge of Integrase Inhibitors : HIV CLINICAL FORUM WEBSITE In order to keep the HIV CLINICAL FORUM participants engaged, we have developed a Neutral 5% Disagree/stro ngly disagree 0% complementary website entitled FORUM.com. Strongly agree/agree 95% This online platform offers the following opportunities: - An online information point on upcoming HIV CLINICAL FORA The program is beneficial for the clinical management of my patients : - Sharing of workshop materials (presentations, abstracts, case discussions, etc) Neutral 3% Strongly agree/agree 97% Disagree/stro ngly disagree 0% - A source for articles and research results on HIV CLINICAL FORA topics - Posting of regular news items on developments in the field - Online interaction with peers through an I intend to incorporate the new information into the case of my patients : interactive forum - Increasing networks and building collaborations 6

7 MISSION To optimize HIV patient care by educating the HIV Medical Community on topics that are clinically relevant through focused and interactive HIV CLINICAL FORA. Ultimately the HIV CLINICAL FORA aim at building a global online community of HIV medical professionals. 7

GLOBAL HIV CLINICAL FORUM ON INTEGRASE INHIBITORS - DURBAN, SOUTH AFRICA 16 JULY 2016 The Forum Chairs are responsible for overseeing and coordinating the whole conference To identify workshop tasks

This Forum is an official pre-conference of the AIDS conference in Durban, South Africa (18-22 July 2016).

them To build a schedule and structure for the workshop To define the scope and focus of the workshop To identify topics and speakers and develop the scientific program To identify topics for

8 GLOBAL HIV CLINICAL FORUM ON INTEGRASE INHIBITORS - DURBAN, SOUTH AFRICA 16 JULY 2016 The Forum Chairs are responsible for overseeing and coordinating the whole conference To identify workshop tasks and people We would like to invite you to consider supporting the organization of the Global HIV CLINICAL FORUM on 16 July This Forum is an official pre-conference of the AIDS conference in Durban, South Africa (18-22 July 2016). The program is being developed by a group of International Key Opinion Leaders PROGRAM CHAIRS The Global HIV FORUM is chaired by: Jonathan Schapiro, MD Zahav Medical Center Israel responsible for them To build a schedule and structure for the workshop To define the scope and focus of the workshop To identify topics and speakers and develop the scientific program To identify topics for abstract submission To guide the abstract reviewing and selection process To be present throughout the workshop To introduce, summarize and close the workshop To potentially take up other tasks during the workshop Charles Boucher, MD, PhD Erasmus Medical Center the Netherlands Andrew Kambugu, MD Makarere University Uganda SCIENTIFIC COMMITTEE Scientific Committee members have an advising role with regard to the Scientific Program and act as ambassadors of the meeting. We are proud of our international Scientific Committee: Tasks: Loice Achieng, MD University of Nairobi, Kenya 8

9 Ava Avalos, MD Careena Medical Center, Botswana Mauro Schechter, MD, PhD Federal University Rio de Janeiro, Brazil Anchalee Avihingsanon, MD HIV-NAT and Chulalongkorn University, Bangkok, Thailand François Venter, MD, FCP Reproductive Health and HIV Research Unit, South Africa Pedro Cahn, MD, PhD Fundacion Huesped, Argentina Stefano Vella, MD Instituto Superiore di Sanità, Rome, Italy Mark Cotton, MD Faculty of Health Sciences, South Africa Jun Yong Choi, Md, PhD Severance Hospital, Yonsei University, Seoul, South Korea AnnaMaria Geretti, MD, PhD University of Liverpool, United Kingdom Tasks: Andrea de Luca, MD Catholic University, Rome and Siena University Hospital, Siena, Italy Flavia Mugala-Mukungu, MD Windhoek, Namibia Victor Musiime, MBChB, MMed, PhD Joint Clinical Research Centre, Uganda Praphan Phanuphak, MD, PhD The Thai Red Cross AIDS Research Centre, Thailand Anton Pozniak, MD, FRCP Chelsea and To suggest topics and speakers To suggest topics for abstract submission To review abstracts To take up roles as session chair or case discussant To be present throughout the workshop and actively participate in discussions and Q&A sessions To promote the meeting within their professional network To encourage the medical community in their country to submit research results and to participate in the meeting Westminster Hospital, United Kingdom 9

FACULTY The HIV CLINICAL FORUM Chairs, together with the Scientific Committee, have selected key ACCREDITATION We will apply for CME accreditation from the South African HIV Society.

10 FACULTY The HIV CLINICAL FORUM Chairs, together with the Scientific Committee, have selected key ACCREDITATION We will apply for CME accreditation from the South African HIV Society. opinion leaders to give plenary lectures, to act as case discussants and as session chairs. FORMAT & LOCATION The program will include plenary lectures followed LEARNING OBJECTIVES - Participants will have a good knowledge of the basic science of Integrase Inhibition - Participants will have a profound knowledge on how and when to apply Integrase Inhibitors in daily clinical practice - Participants will have a profound knowledge of the resistance characteristics of Integrase by ample time for Q&A and debate, stimulating interaction in order to bridge the knowledge gap between experts and the HIV treatment community. The Global HIV FORUM takes place in the International Convention Center in Durban, SA, which is the official 2016, AIDS conference venue. Inhibitors - Participants will be updated on treatment results of ongoing studies and clinical case studies - Participants will acquire new skills in order to be able to develop new clinical trials and to interpret dataset results - Participants will have a profound knowledge of the future treatment opportunities involving integrase inhibitors ENDORSEMENT We will request endorsement from international, regional and national societies. 10

PRELIMINARY PROGRAM GLOBAL HIV CLINICAL FORUM 9.

15h Basic Science of Integrase Inhibitors Andrea de Luca, MD Catholic University,

00h Resistance characteristics of Integrase inhibitors Charles Boucher, PhD, MD

15h Pharmacological considerations Anna Maria Geretti, MD, PhD University of

00h Integrating science into the clinic: current and future use of Integrase

00h LUNCH 14.00h ABSTRACT PRESENTATIONS 15.

11 PRELIMINARY PROGRAM GLOBAL HIV CLINICAL FORUM 9.00h Opening & Welcome Workshop Chairs 9.15h Basic Science of Integrase Inhibitors Andrea de Luca, MD Catholic University, Rome, Italy Siena University Hospital, Siena, Italy 10.00h Resistance characteristics of Integrase inhibitors Charles Boucher, PhD, MD Erasmus Medical Center, Rotterdam, The Netherlands 10.45h COFFEE BREAK 11.15h Pharmacological considerations Anna Maria Geretti, MD, PhD University of Liverpool, Liverpool, United Kingdom 12.00h Integrating science into the clinic: current and future use of Integrase Inhibitors Anton Pozniak, MD, FRCP Chelsea and Westminster Hospital, London, UK 13.00h LUNCH 14.00h ABSTRACT PRESENTATIONS 15.00h HIV Therapy in Populations with Unique Challenges Pediatrics Victor Musiime, MBChB, MMed, PhD Joint Clinical Research Centre, Kampala, Uganda 15.45h COFFEE BREAK Optimizing HIV Therapy in Resource Limited Settings Francois Venter, MD University of the Witwatersrand, Johannesburg, South Africa 11

12 16.45h CLINICAL CASE DISCUSSIONS 17.45h Future Challenges of HIV treatment Stefano Vella, MD Istituto Superiore di Sanità, Rome, Italy 18.30h Closure Workshop Chairs 12

13 REQUEST FOR SUPPORT We very much hope you are interested in supporting the organization of the Global HIV CLINICAL FORUM on Integrase Inhibitors. Your support will allow us to cover the costs involved with the organization of the conference. By supporting this program you will be able to demonstrate your commitment to educating the HIV medical community on optimal use of integrase inhibitors in daily clinical management. Please contact us to get an overview of the support opportunities and benefits. Phone:

VIROLOGY EDUCATION BILTSTRAAT 106 3572 BJ UTRECHT THE

14 Would you like to learn more about our initiatives, programs and opportunities for collaboration, please contact us! VIROLOGY EDUCATION BILTSTRAAT BJ UTRECHT THE NETHERLANDS

INTERNATIONAL WORKSHOP ON HIV & TRANSGENDER PEOPLE MEXICO CITY, MEXICO JULY 2019 MEETING PROSPECTUS.

INTERNATIONAL WORKSHOP ON HIV & TRANSGENDER PEOPLE MEXICO CITY, MEXICO JULY 2019 MEETING PROSPECTUS INTRODUCTION Dear Colleagues, It is our pleasure to announce the organization of the first Workshop focusing