EVOLUŢIA INFECŢIEI HIV/SIDA ÎN ROMÂNIA 30 IUNIE 2014

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1 EVOLUŢIA INFECŢIEI HIV/SIDA ÎN ROMÂNIA 30 IUNIE 2014

2 Datele sunt obţinute din informaţiile culese de pe fişele de confirmare a infecţiei HIV/SIDA, primite din Centrele Regionale de Evaluare şi Monitorizare a Infecţiei HIV/SIDA şi prelucrate la Compartimentul pentru Monitorizarea şi Evaluarea Infecţiei HIV/SIDA în România, din cadrul Institutului Naţional de Boli Infecţioase Prof.dr.Matei Balş Bucureşti.

3 ARONDAREA JUDEŢELOR LA CENTRELE REGIONALE PENTRU MONITORIZAREA ŞI EVALUAREA INFECŢIEI HIV/SIDA CENTRUL REGIONAL INBI PROF.DR. MATEI BALŞ BUCUREŞTI ARGEŞ BUZĂU DAMBOVIŢA GALAŢI IALOMIŢA PRAHOVA ILFOV VÂLCEA CENTRUL REGIONAL CRAIOVA CENTRUL REGIONAL CONSTANŢA DOLJ GORJ MEHEDINŢI OLT CONSTANŢA TULCEA VRANCEA CENTRUL REGIONAL V. BABEŞ BUCUREŞTI BRĂILA CĂLĂRAŞI GIURGIU TELEORMAN V.BABEŞ- BUCUREŞTI CENTRUL REGIONAL IAŞI BACĂU BOTOŞANI IAŞI NEAMŢ SUCEAVA VASLUI CENTRUL REGIONAL BRAŞOV BRAŞOV COVASNA HARGHITA CENTRUL REGIONAL TÂRGU MUREŞ ALBA BISTRIŢA NĂSĂUD MUREŞ SIBIU BIHOR CENTRUL REGIONAL CLUJ CLUJ MARAMUREŞ SATU MARE SĂLAJ CENTRUL REGIONAL TIMIŞOARA ARAD CARAŞ SEVERIN HUNEDOARA TIMIŞ

4 MINISTERUL SĂNĂTĂŢII INSTITUTUL NAŢIONAL DE BOLI INFECŢIOASE PROF.DR.MATEI BALŞ Compartimentul pentru Monitorizarea şi Evaluarea Infecţiei HIV/SIDA în România DATE GENERALE LA 30 IUNIE 2014 TOTAL HIV/SIDA (CUMULATIV ) DIN CARE: Cazuri HIV/SIDA copii (0-14 ani la data diagnosticului) Cazuri HIV/SIDA adulţi (> 14 ani la data diagnosticului) Total decese SIDA ( ) Pierduţi din evidenţă HIV/SIDA copii + adulţi 620 NUMĂR PACIENŢI HIV/SIDA ÎN VIAŢĂ TOTAL SIDA (CUMULATIV ) Cazuri SIDA copii (0-14 ani la data diagnosticului) Cazuri SIDA adulţi (> 14 ani la data diagnosticului) TOTAL HIV (CUMULATIV ) Cazuri HIV copii (0-14 ani la data diagnosticului) Cazuri HIV adulţi (> 14 ani la data diagnosticului) CAZURI HIV/SIDA NOI, DEPISTATE ÎN PERIOADA CAZURI NOI HIV NOTIFICATE 177 CAZURI NOI SIDA NOTIFICATE 142 DECESE înregistrate în perioada prin fişele de confirmare a cazului HIV/SIDA 86

5 MINISTERUL SĂNĂTĂŢII INSTITUTUL NAŢIONAL DE BOLI INFECŢIOASE PROF.DR.MATEI BALŞ Compartimentul pentru Monitorizarea şi Evaluarea Infecţiei HIV/SIDA în România DATE GENERALE LA 30 IUNIE 2014 Pacienţi în evidenţă activă HIV+SIDA*** Copii (0-14 ani*) 304** Adulţi (> 14 ani*) Pacienţi în tratament antiretroviral**** Copii (0-14 ani*) 217 Adulţi (> 14 ani*) *vârsta actuala **Sunt incluşi şi nou născuţii expuşi perinatal HIV în anul 2014, aflaţi în monitorizare Sursa: ***Compartimentul pentru Monitorizarea şi Evaluarea Infecţiei HIV/SIDA în România INBI Prof.Dr.M.Balş ****Unitatea de Asistenţă tehnică şi management al Programului Naţional de Supraveghere şi Control al Infecţiei HIV

6 PIRAMIDA VÂRSTELOR 31 DECEMBRIE 2013 VÂRSTA LA DATA DEPISTĂRII/NOTIFICĂRII TOTAL CUMULATIV DISTRIBUŢIA PE VÂRSTE A PACIENŢILOR AFLAŢI ÎN VIAŢĂ

7 Cazuri noi HIV/SIDA 1 IANUARIE-30 IUNIE 2014

8 DISTRIBUŢIA PE JUDEŢE A CAZURILOR NOI DE INFECŢIE HIV/SIDA, DEPISTATE PERIOADA LEGENDA COPII (0-14 ANI) ADULTI şi ADOLESCENŢI (> 14 ANI) Ilfov: 14 adulţi 1 copil

9 DISTRIBUŢIA PE SEXE A CAZURILOR NOI DE INFECŢIE HIV/SIDA DEPISTATE ÎN PERIOADA (24%) 243 (76%) MASCULIN FEMININ

10 DISTRIBUŢIA CAZURILOR NOI DE INFECŢIE HIV/SIDA, DEPISTATE ÎN PERIOADA , PE GRUPE DE VÂRSTĂ ŞI SEX < 1 an ani ani ani ani ani ani ani >=60 ani MASCULIN FEMININ

11 DISTRIBUŢIA CAZURILOR NOI DE INFECŢIE HIV/SIDA LA COPII, DEPISTATE ÎN PERIOADA , DUPĂ CALEA PROBABILĂ DE TRANSMITERE MATERNO-FETALA MASCULIN FEMININ

12 DISTRIBUŢIA CAZURILOR NOI DE INFECŢIE HIV/SIDA LA ADULŢI, DEPISTATE ÎN PERIOADA , DUPĂ CALEA PROBABILĂ DE TRANSMITERE BSB/BISEXUAL UTILIZATORI DE DROGURI IV* HETEROSEXUAL NECUNOSCUT MASCULIN FEMININ *La data de s-au inregistrat 81 de cazuri HIV/SIDA/IDU, 76 raportate la calea de transmitere IDU si 5 raportate la calea de transmitere BSB/Bisexual

13 VALORI ALE LIMFOCITELOR CD4 LA CAZURILE NOI DEPISTATE ÎN SEMESTRUL I 2014 Număr celule/mm 3 TOTAL CAZURI NOI: % 7% 25% 34% < > 500 Neevaluat 11%

14 VALORI ALE LIMFOCITELOR CD4 LA CAZURILE NOI DEPISTATE ÎN SEMESTRUL I ADULŢI Număr celule/mm 3 MASCULIN FEMININ 20% 7% 26% 29% 3% 25% 35% 12% 35% 8% < < > > 500 Neevaluat Neevaluat TOTAL CAZURI: 241 TOTAL CAZURI: 73

15 VALORI ALE VL LA CAZURILE NOI DEPISTATE ÎN SEMESTRUL I ADULŢI - Număr copii/ml MASCULIN FEMININ 50% 4% 49% 12% 10% 14% 10% 10% 16% 8% 5% 12% < > In curs de evaluare Neevaluat < > In curs de evaluare Neevaluat

16 Cazuri noi HIV/IDU (consumatori de droguri injectabile) 1 ianuarie-30 iunie 2014

17 Cazuri noi de infecţie HIV/SIDA (ianuarie iunie 2014) cu transmitere prin utilizare de droguri I.V. pe grupe de vârstă

18 Cazuri noi de infecţie HIV/SIDA (ianuarie iunie 2014) cu transmitere prin utilizare de droguri I.V. pe grupe de vârstă 7,41% Total 4,94% 16,05% 17,28% 27,16% 27,16% ani ani ani 30-34ani ani ani

19 Cazuri noi de infecţie HIV/SIDA (ianuarie iunie 2014) cu transmitere prin utilizare de droguri I.V. pe judeţe Judeţ Masculin Feminin Total Bacau 1 1 Braşov 1 1 Bucureşti Constanta 1 1 Dambovita 1 1 Galati 1 1 Ilfov 6 6 Timiş 1 1 Total

20 Coinfecţii HIV/HBV, HCV, BTS şi TBC la utilizatorii de droguri I.V. Testat pentru Numar pacienţi cu test pozitiv % AgHBs % VHC % AgHBs + VHC % BTS (boli cu transmitere sexuală) % TBC %

21 Coinfecţii HIV/HBV, HCV, BTS şi TBC la utilizatorii de droguri I.V. 18,52% 3,70% 11,11% 8,64% HBV HCV HBV+HCV SIFILIS TBC 76,54%

22 TIPURI DE DROGURI FOLOSITE DE PACIENŢII HIV POZITIVI CDI DEPISTAŢI ÎN ANUL , (14%) 31, (38%) 12, (15%) 27, (33%) HEROINA ETNOBOTANICE HEROINA+ETNOBOTANICE NESPECIFICAT

23 Utilizatori de droguri I.V. depistaţi HIV+ în perioada ianuarieiunie 2014, testaţi anterior testului HIV pozitiv ANUL TESTĂRII ANTERIOARE NR.PACIENŢI Total testati anterior 11

24 CAZURI NOI DE INFECTIE HIV/SIDA RAPORTATE IN BAZA NATIONALA IN ANII VERSUS CAZURI NOI DE INFECTIE HIV/SIDA LA UTILIZATORII DE DROGURI I.V. RAPORTATE IN BAZA NATIONALA IN ANII ANUL CRITERIU NUMAR CAZURI DE INFECTIE HIV TOTAL din care IDU TOTAL din care IDU TOTAL din care IDU TOTAL din care IDU TOTAL din care IDU TOTAL din care IDU NUMAR CAZURI SIDA TOTAL CAZURI DE INFECTIE HIV/SIDA

25 Valori ale limfocitelor CD4 la utilizatorii de droguri i.v. depistaţi cu infecţie HIV/SIDA în semestrul I 2014 (cel/mmc) 25% 1% 30% 32% < >=500 FARA 12%

26 EVOLUȚIA INFECȚIEI HIV/SIDA

27 PIRAMIDA VÂRSTELOR 31 DECEMBRIE 2013 VÂRSTA LA DATA DEPISTĂRII/NOTIFICĂRII TOTAL CUMULATIV DISTRIBUŢIA PE VÂRSTE A PACIENŢILOR AFLAŢI ÎN VIAŢĂ

28 Distribuţia cazurilor HIV/SIDA în viaţă pe grupe de vârstă după vârsta actuală şi sex la 30 iunie 2014 (total cumulativ ) GRUPA DE VARSTA SEX MASCULIN FEMININ TOTAL < 1 an ani ani ani ani ani ani ani ani ani ani ani ani si peste TOTAL

29 TENDINŢE ÎN CALEA DE TRANSMITERE ÎN ROMÂNIA CALEA DE TRANSMITERE 31.dec dec dec dec dec dec dec iunie 2014 Verticală 8 (2%) 7 (1%) 20 (4%) 25 (5%) 21 (3%) 21 (2.6%) 21 (2.64%) 5 (1.57%) BSB (Bărbaţi sex cu bărbaţi) 14 (3%) 40 (8%) 44 (9%) 60 (11%) 95 (13%) 89 (10.8%) 88 (11.04%) 43 (13.48%) CDI (Consumatori de droguri i.v.) 4 (1%) 3 (1%) 7 (1.4%) 14 (3%) 131 (18%) 252 (30.6%) 233 (29.23%) 76 (23.82%) BSB/CDI 1 (<0.5%) 5 (1%) 6 (1%) 5 (0.63%) 5 (1.57%) Heterosexuală 352 (79%) 397 (76%) 383 (77%) 399 (75%) 440 (61%) 414 (50%) 435 (54.58%) 180 (56.43%) Necunoscută 67 (15%) 71 (14%) 43(8.6%) 32 (6%) 28 (4%) 39 (5%) 15 (1.88%) 10 (3.13%) Total* *Reactualizarea datelor cu intarzierile in raportarea si confirmarea cazurilor se face anual

30 DISTRIBUŢIA PE SEXE A CAZURILOR SIDA LA 30 IUNIE 2014 (TOTAL CUMULATIV ) MASCULIN FEMININ

31 DISTRIBUŢIA PE GRUPE DE VÂRSTĂ (LA DATA DIAGNOSTICULUI) ŞI SEX A CAZURILOR SIDA LA 30 IUNIE 2014 (TOTAL CUMULATIV ) < 1 AN 1-4 ANI 5-9 ANI ANI ANI ANI ANI ANI ANI >=60 ANI MASCULIN FEMININ

32 CALEA PROBABILĂ DE TRANSMITERE LA COPIII CU SIDA (0-14 ANI LA DATA DIAGNOSTICULUI) LA 30 IUNIE 2014 (TOTAL CUMULATIV ) MATERNO-FETALA SANGE SI DERIVATE* NOZOCOMIAL** HETEROSEXUAL NECUNOSCUT MASCULIN FEMININ *Persoane care au primit transfuzii la sfârşitul anilor 80 începutul anilor 90 **Persoane care au internări repetate şi/sau tratamente parenterale multiple la sfârşitul anilor 80 începutul anilor 90

33 CALEA PROBABILĂ DE TRANSMITERE LA ADOLESCENŢII ŞI ADULŢII CU SIDA (> 14 ANI LA DATA DIAGNOSTICULUI) LA 30 IUNIE 2014 (TOTAL CUMULATIV ) HOMO/BISEXUAL UTILIZATORI DE DROGURI IV SANGE SI DERIVATE* HETEROSEXUAL NECUNOSCUT MASCULIN FEMININ *Persoane care au primit transfuzii la sfârşitul anilor 80 începutul anilor 90

34 Distribuţia cazurilor SIDA la femei pe grupe de vârstă şi după anul de diagnostic între anii ANI ANI ANI ANI >50 ANI

35 DISTRIBUŢIA PE SEXE A CAZURILOR DE INFECŢIE HIV LA 30 IUNIE 2014 (TOTAL CUMULATIV ) MASCULIN FEMININ

36 DISTRIBUŢIA PE GRUPE DE VÂRSTĂ (LA DATA DIAGNOSTICULUI) ŞI SEX A CAZURILOR DE INFECŢIE HIV LA 30 IUNIE 2014 (TOTAL CUMULATIV ) < 1 AN 1-4 ANI 5-9 ANI ANI ANI ANI ANI ANI ANI >=60 ANI 17 MASCULIN FEMININ

37 CALEA PROBABILĂ DE TRANSMITERE LA COPIII CU INFECŢIE HIV (0-14 ANI LA DATA DIAGNOSTICULUI) LA 30 IUNIE 2014 (TOTAL CUMULATIV ) MATERNO- FETALA SANGE SI DERIVATE* NOZOCOMIAL** UTILIZATORI DE DROGURI IV HETEROSEXUAL NECUNOSCUT MASCULIN FEMININ *Persoane care au primit transfuzii la sfârşitul anilor 80 începutul anilor 90 **Persoane care au internări repetate şi/sau tratamente parenterale multiple la sfârşitul anilor 80 începutul anilor 90

38 CALEA PROBABILĂ DE TRANSMITERE LA ADOLESCENŢII ŞI ADULŢII CU INFECŢIE HIV (> 14 ANI LA DATA DIAGNOSTICULUI) LA 30 IUNIE 2014 (TOTAL CUMULATIV ) HOMO/BISEXUAL 91 UTILIZATORI DE DROGURI IV SANGE SI DERIVATE* HETEROSEXUAL NECUNOSCUT MASCULIN FEMININ *Persoane care au primit transfuzii la sfârşitul anilor 80 începutul anilor 90

39 Distribuţia cazurilor de infecţie HIV la femei după anul de diagnostic şi grupa de vârstă ( ) ani ani ani ani >50 ani

40 Coinfecţii HIV/VHB, VHC şi VHB+VHC la copiii seropozitivi HIV în perioada VHB+VHC VHC VHB 50 0 '89 '90 '91 '92 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 ' VHB+VHC VHC VHB

41 Coinfecţie HIV/VHB, VHC şi VHB+VHC la adulţii seropozitivi HIV în perioada '85 '86 '87 '88 '89 '90 '91 '92 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 ' VHB+VHC VHC VHB VHB VHC VHB+VHC

42 BOLI ASOCIATE SIDA ÎN PERIOADA Tumora - altele Tuberculoza pulmonara Tuberculoza extrapulmonara Toxoplasmoza Sindrom wasting Sepsis recurent Sarcom Kaposi Pneumonie recurenta Pneumonie cu pneumocistis carinii Mycob. tub. diseminata Limfom Burkitt/altele Leucoencefalopatia multifocala progresiva Infectii bacteriene recurente Infectia cu Herpes Simplex Virus Encefalopatie HIV Criptococoza CMV Boala Candidoza pulmonara: bronhii/trahee/plaman Candidoza esofagiana Candidoza bronsica Cancer cervical inv

43 DECESE PE ANI an

44 TESTĂRI HIV IANUARIE-IUNIE 2014

45 TESTĂRI* HIV LA GRUPE DE RISC ÎN SEMESTRUL I 2014 Grupa de risc Teste negative Teste pozitive TOTAL %POZITIV BTS TBC MATERNITATE GRAVIDE PERSONAL MEDICO-SANITAR HEMODIALIZATI TRANSFUZATI CONTROL PRENUPTIAL UTILIZATORI DE DROGURI DETINUTI BSB (bărbaţi sex cu bărbaţi) PRACTICANTI SEX COMERCIAL CONTACTI HIV MARINARI SOFERI LUCRU IN STRAINATATE > 6 LUNI SEJUR IN STRAINATATE > 6 LUNI LA CERERE OCAZIONALE TOTAL *Datele sunt primite de la Autorităţile Judeţene de Sănătate Publică

46 TESTĂRI * HIV LA GRAVIDE, PE GRUPE DE VÂRSTĂ, ÎN SEMESTRUL I 2014 Grupa de vârstă Teste negative Teste pozitive TOTAL %POZITIV ani ani ani ani ani ani > 40 ani Vârsta neprecizată TOTAL *Datele sunt primite de la Autorităţile Judeţene de Sănătate Publică

47 TESTĂRI HIV LA DONATORII DE SÂNGE* IN SEMESTRUL I 2014 GRUPA DE DONARE SEX POZITIV NEGATIV TOTAL PRIMA DONARE DONARE REGULATĂ DONARE OCAZIONALĂ Masculin Feminin Masculin Feminin Masculin Feminin TOTAL *Datele sunt primite de la Institutul Naţional de Hematologie Transfuzională PROF.C.T.NICOLAU

48 EVOLUȚIA FENOMENULUI HIV/SIDA ÎN LUME

49 UNAIDS: How to get to ZERO: ZERO NEW HIV INFECTIONS. ZERO DISCRIMINATION. ZERO AIDS-RELATED DEATHS

50 Sursa: Global Update on HIV Treatment 2013: Results, impact and opportunities WHO Report in partnership with UNICEF and UNAIDS, June 2013

51 Sursa: Global Update on HIV Treatment 2013: Results, impact and opportunities WHO Report in partnership with UNICEF and UNAIDS, June 2013

52 Sursa: Global Update on HIV Treatment 2013: Results, impact and opportunities WHO Report in partnership with UNICEF and UNAIDS, June 2013

53 Sursa: UNAIDS DATE GENERALE HIV/SIDA ÎN LUME 2013 Total 35 milioane (33,2 37,2 milioane) Număr persoane în viaţă cu HIV/SIDA Persoane infectate cu HIV în anul 2013 Adulţi Femei Copii < 15 ani Total Adulţi 31,8 milioane (30,1 33,7 milioane) 16,0 milioane (15,2 16,9 milioane) 3,2 milioane (2,9 3,5 milioane) 2,1 milioane (1,9 2,4 milioane) 1,9 milioane (1,7 2,1 milioane) Copii < 15 ani ( ) Decese cauzate de SIDA în 2013 Total Adulţi 1,5 milioane (1,4 1,7 milioane) 1,3 milioane (1,2 1,5 millioane) Copii < 15 ani ( )

54 milioane Sursa: UNAIDS ESTIMĂRI PRIVIND NUMĂRUL DE PERSOANE CU INFECŢIE HIV/SIDA AFLATE ÎN VIAŢĂ

55 Sursa: UNAIDS ESTIMĂRI GLOBALE PENTRU ADULŢI ŞI COPII 2013 Persoane aflate în viaţă cu HIV: 35 milioane (33,2 37,2 milioane) Cazuri noi de infecţie HIV în ,1 milioane (1,9 2,4 milioane) Decese cauzate de SIDA în ,5 milioane (1,4 1,7 milioane)

56 ESTIMĂRI PRIVIND NUMĂRUL DE COPII ŞI ADULŢI CU INFECŢIE HIV AFLAŢI ÎN VIAŢĂ 2013 Sursa: UNAIDS

57 ESTIMĂRI PRIVIND NUMĂRUL DE ADULŢI ŞI COPII INFECTAŢI CU HIV ÎN ANUL 2013 Sursa: UNAIDS

58 Estimări privind decesele cauzate de SIDA (adulţi şi copii) în cursul anului 2013 Sursa: UNAIDS

59 Sursa: UNAIDS Aproape de persoane nou infectate pe zi, în lume în anul 2013 Peste 68% provin Africa Subsahariană Aproape 700 sunt copii cu vârsta sub 15 ani Aproape sunt persoane cu vârsta peste 15 ani, din care: aprox. 47% sunt femei aprox. 33% au vârsta cuprinsă între ani

60 Sursa: UNAIDS Global Report Epidemiology September 2013 ESTIMĂRI GLOBALE HIV ŞI SIDA LA SFÂRŞITUL ANULUI 2013 COPII (<15 ANI) Copii cu HIV aflaţi în viaţă 3,2 milioane (2,9 3,5 milioane) Copii nou infectaţi cu HIV în ( ) Decese cauzate de SIDA în ( )

61 Sursa: UNAIDS DATE STATISTICE REGIONALE DECEMBRIE 2013

62 ESTIMĂRI HIV/SIDA ÎN REGIUNEA OMS EUROPA (53 DE ŢĂRI) Cazuri raportate HIV/SIDA (total cumulativ): Cazuri SIDA: Decese SIDA: Infecţie HIV: Sursa: HIV surveillance Report 2012

63 CARACTERISTICI ALE CAZURILOR DE INFECŢIE HIV DIAGNOSTICATE ÎN REGIUNEA EUROPEANĂ OMS ÎN ANUL 2012, PE ARII GEOGRAFICE Regiunea Europeană OMS Vest Centru Est Ţări EU/EEA Ţări care au raportat/număr ţări 51/53 23/23 15/15 13/15 30/31 Număr cazuri de infecţie HIV Rata per populaţie 7,8 6,6 1,9 22 5,8 % din cazuri: Grupa de vârstă ani 10,3% 9,8% 15,4% 10,1% 10,6% Raport bărbaţi/femei 2,1 3,1 4,5 1,4 3,2 Calea de transmitere Heterosexual 45,6% 35,3% 24,6% 60,2% 33,8% BSB 22,8% 41,7% 26,3% 1,2% 40,4% Droguri IV 17,8% 5,1% 7,4% 33,6% 6,1% Necunoscut 12,3% 17% 36,9% 3,2% 18,7% Fără date din: Liechtenstein, Rusia şi Uzbekistan; Ţările care nu au raportat grupele de vârstă şi modul de transmitere sunt excluse *include persoane (12%) originare din ţări ale Africii Subsahariene; Sursa: HIV/AIDS surveillance Report 2012

64 Sursa: UNAIDS WORLD AIDS DAY REPORT 2012 *Surse Global Update on HIV Treatment 2013: Results, impact and opportunities WHO Report in partnership with UNICEF and UNAIDS, June Unaids World AIDS Day Report HIV/AIDS Surveillance in Europe 2012, ECDC

65 Surse Revised surviellance Case Definition for HIV Infection Among Adults, Adolescents, and Children Aged < 18 Month sand for HIV Infection and AIDS Among Children Aged 18 Months to <13 years--- CDC, United States, CASE DEFINITIONS OF COMMUNICABLE DISEASES 27:EN:PDF The WHO case definition of HIV surveillance is available at:

66 CASE DEFINITIONS OF COMMUNICABLE DISEASES ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) AND HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION Clinical Criteria (AIDS) Any person who has any of the clinical conditions as defined in the European AIDS case definition for: Adults and adolescents 15 years Children < 15 years of age Laboratory Criteria (HIV) Adults, adolescents and children aged 18 months At least one of the following three: Positive result of a HIV screening antibody test or a combined screening test (HIV antibody and HIV p24 antigen) confirmed by a more specific antibody test (e.g. Western blot) Positive result of 2 EIA antibody test confirmed by a positive result of a further EIA test Positive results on two separate specimens from at least one of the following three: Detection of HIV nucleic acid (HIV-RNA, HIV-DNA) Demonstration of HIV by HIV p24 antigen test, including neutralisation assay Isolation of HIV Children aged < 18 months Positive results on two separate specimens (excluding cord blood) from at least one of the following three: Isolation of HIV Detection of HIV nucleic acid (HIV-RNA, HIV-DNA) Demonstration of HIV by HIV p24 antigen test, including neutralisation assay in a child 1 month of age

67 Epidemiological Criteria NA Case Classification A. Possible case NA B. Probable case NA C. Confirmed case HIV infection Any person meeting the laboratory criteria for HIV infection AIDS Any person meeting the clinical criteria for AIDS and the laboratory criteria for HIV infection

68 INSTITUTUL NAŢIONAL DE BOLI INFECŢIOASE PROF.DR.MATEI BALŞ COMPARTIMENTUL PENTRU MONITORIZAREA ŞI EVALUAREA INFECŢIEI HIV/SIDA ÎN ROMÂNIA Manager: Prof.Dr. Adrian Streinu-Cercel Şef Catedră Boli Infecţioase UMF Carol Davila Preşedinte al Comisiei de Boli infecţioase şi de Luptă Anti-SIDA Coordonator: Dr. Mariana Mărdărescu Coordonator program Adulţi: Conf.Dr.Elisabeta Otilia Benea Coordonator program Copii: Dr.Sorin Petrea Prelucrări date statistice: Operatori PC: As.med. Marieta Iancu Daniela Viţelaru Sanda Vintilă Colaborator: Dr. Ionel Iosif CNSCBT

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