Prof. Dr. Kutikuppala Surya Rao MD.,PhD.,MNAMS.,FHM(CMC Vellore) DFM.,FCGP.,FRCP(London)

Size: px
Start display at page:

Download "Prof. Dr. Kutikuppala Surya Rao MD.,PhD.,MNAMS.,FHM(CMC Vellore) DFM.,FCGP.,FRCP(London)"

Transcription

1 A Study of HPV genotypes in HIV-Positive Women for early detection of risk for cervical cancers in Andhrapradesh, India. Prof. Dr. Kutikuppala Surya Rao MD.,PhD.,MNAMS.,FHM(CMC Vellore) DFM.,FCGP.,FRCP(London) Dept.of Bio-Technology Jawaharlal Nehru Technological University,Hyd,India CHIEF PHYSICIAN,Dr.kksr Hospital Visakhapatnam ,India kutikuppalasuryarao@gmail.com 1

2 BACKGROUND Cervical cancer is the most common cancer among women in India. The association between cervical cancer and human papillomavirus (HPV) is well known. However not much data on the prevalence of HPV genotypes among HIV positive women in India. There are at least 15 high-risk (Oncogenic) subtypes of HPV. 2

3 HPV INDUCED ANNUAL NUMBER OF CASES WORLD WIDE 3

4 4

5 5

6 BACKGROUND Overall, HPV-16 and HPV-18 account for approximately 70% of all cervical cancers diagnosed worldwide each year.hpv-16, most prevalent genotype in world including India with preferential risk for both squamous cell carcinoma and adeno carcinoma. 6

7 WORLD WIDE SURVEY 7

8 BACKGROUND HPV-18 is the second most prevalent high risk genotype in world including India with preferential risk for adeno carcinoma. In this back ground we studied the prevalence of HPV genotypes among HIV positive women in Andhra Pradesh,India 8

9 METHODS We conducted a cross-sectional, observational study on 350 HIV Positive women age ranging from 25 to 54 years after following the ethical guidelines from April 2011 to March 2013 at KKSR Hospital, Visakhapatnam. Cervical swab samples were sent for HPV genotyping to Biognosys technologies India Pvt Ltd and Dr.Lal Path Labs,New Delhi 9

10 10

11 METHODS In HPV qualitative PCR the DNA is extracted from cervical swab and is subjected to genotype specific PCR using HPV 16 and 18 primers. The amplification product from PCR is checked by Agarose gel electrophoresis. The positive amplification reflects as band on Agarose gel. 11

12 Results EIGHTY TWO-82 (23.4%) out of 350 samples tested had HPV subtypes detected In the age groups of 25 to cases (29.2%) 35 to cases (21.95%) 45 to cases (32.8%) 12

13 13

14 Comparing the Relation between HPV Genotypes and Cervical Cancer in Multiethnic Groups Study Overall HPV was detected in 92.5% of cases, in 95.9% of squamous cell carcinomas and 84.3%of adeno carcinomas. The five most prevalent high-risk HPV genotypes were HPV 16 (68.2%), 18 (40%), 58 (10.7%), 33 (10.4%) and 52 (10.4%) in HIV Negative Women Sayyidi Hamzi Abdul Raub et al - Asian Pacific Journal of Cancer Prevention, Vol 15,

15 RESULTS The most common high risk genotypes encountered in our study were HPV-16-18/82 (21.95%) HPV /82 (18.29%) 15

16 LITERATURE REVIEW Reports on HPV prevalence published between January, 1995, and and January, 2005 were retrieved. Overall HPV prevalence in 1, women with normal cervical cytology was estimated to be 10 4% Corresponding estimates by region were Africa 22 1%, Central America and Mexico 20 4%. northern America 11 3%,Europe 8 1% and Asia 8 0% -the lancet.com Vol 7 July

17 HIGH RISK GENOTYPES in HIV-Positive Women in Visakhapatnam, Andhrapradesh, India 17

18 RESULTS We found that HIV-positive women were more likely to test positive for any HPV as (P <.05), and to test positive for the high risk subtypes as (P <.05) which is statistically significant. 18

19 Comparing the Relation between HPV Genotypes and Cervical Cancer in Multiethnic Groups Study The percentage of HPV positive cases in Chinese, Malays and Indians were 95.5%, 91.9% and 80.0%, respectively. HPV 16 and 18 genotypes were the commonest in all ethnic groups. The percentage of HPV 16 infection was significantly higher in Chinese (75.9%) compared to Malays (63.7%) and Indians (52.0%) (p<0.05), The HPV 18 was significantly higher in Malays (52.6%) compared to Chinese (25.0%) and Indians (28%) (p<0.05) in HIV Negative Women - Asian Pacific Journal of Cancer Prevention, Vol 15,

20 CONCLUSIONS As the Oncogenic HPV subtypes 16 and 18 were more prevalent in this study, further studies are needed on more number of samples to design preventive strategy and to administer HPV vaccine as a public health measure. Supplementary routine screening for HPV DNA will assist to reduce the incidence of cervical cancers. 20

21 ACKNOWLEDGEMENTS We sincerely thank the HIV Positive Women who participated in the study. Further we appreciate the services rendered by the staff of Dr. KKSR Hospital, Visakhapatnam, INDIA. Also we show gratitude to Biognosys technologies India Pvt Ltd, Hyderabad and Dr.Lal Path Labs,New Delhi 21

22 22

Human Papillomavirus Genotyping and Cervical Smear in Duhok/Iraq

Human Papillomavirus Genotyping and Cervical Smear in Duhok/Iraq Human Papillomavirus Genotyping and Cervical Smear in Duhok/Iraq Intisar Salim Pity (Professor pathology) MBChB, MSc, FIBMS Hanaa Mohammad Abdo (MSc microbiology) Amer A. Goreal (Microbiology) MBChB, FIBMS

More information

Distribution of HPV Genotypes in Cervical Cancer in Multiethnic

Distribution of HPV Genotypes in Cervical Cancer in Multiethnic DOI:http://dx.doi.org/10.7314/APJCP.2014.15.2.651 Distribution of HPV Genotypes in Cervical Cancer in Multi-ethnic Malaysia RESEARCH ARTICLE Distribution of HPV Genotypes in Cervical Cancer in Multiethnic

More information

Epidemiologia dell HPV e cancro della cervice nel mondo. Silvia Franceschi

Epidemiologia dell HPV e cancro della cervice nel mondo. Silvia Franceschi Epidemiologia dell HPV e cancro della cervice nel mondo Silvia Franceschi Infezione da HPV: dalla diagnosi precoce alla prevenzione primaria. Roma, 27 Giugno 2012 Cancer incidence 2008 attributable to

More information

Prevalence of HPV-16 genomic variant carrying a 63-bp duplicated sequence within the E1 gene in Slovenian women

Prevalence of HPV-16 genomic variant carrying a 63-bp duplicated sequence within the E1 gene in Slovenian women Prevalence of HPV-16 genomic variant carrying a 63-bp duplicated sequence within the E1 gene in Slovenian women K E Y WORDS HPV-16, cervical cancer, E6-T350G variant A BSTRACT High-risk HPV, particularly

More information

Cervical Cancer Screening and Prevention in Latinas. Sandra Torrente, MD, MSc Kenneth Grullon, MD

Cervical Cancer Screening and Prevention in Latinas. Sandra Torrente, MD, MSc Kenneth Grullon, MD ç Cervical Cancer Screening and Prevention in Latinas Sandra Torrente, MD, MSc Kenneth Grullon, MD Objectives Cervical cancer epidemiology Cervical cancer screening rates locally Health Disparities of

More information

Cotton Trade 02/03 03/04 04/05 05/06 06/07 07/08 08/09 09/10 10/11 11/12 12/13

Cotton Trade 02/03 03/04 04/05 05/06 06/07 07/08 08/09 09/10 10/11 11/12 12/13 Cotton Trade Net Exporters Africa Argentina Australia India Other Former Soviet Union Other Latin America Other Middle East Pakistan Turkey United States Uzbekistan Total Net Exports 5.01 5.62 5.62 5.66

More information

HPV AND CERVICAL CANCER

HPV AND CERVICAL CANCER HPV AND CERVICAL CANCER DR SANDJONG TIECHOU ISAAC DELON Postgraduate Training in Reproductive Health Research Faculty of Medicine, University of Yaoundé 2007 INTRODUCTION CERVICAL CANCER IS THE SECOND

More information

Esophageal cancer Study: China Story

Esophageal cancer Study: China Story NCI-IARC Tumor workshop: Esophageal Squamous Cell Carcinoma Esophageal cancer Study: China Story Youlin Qiao, Shaoming Wang Dept. of Cancer Epidemiology Cancer Institute/Hospital Chinese Academy of Medical

More information

Goals. In the News. Primary HPV Screening 3/9/2015. Your PAP and HPV Update Primary HPV Testing- Screening Intervals- HPV Vaccine Updates-

Goals. In the News. Primary HPV Screening 3/9/2015. Your PAP and HPV Update Primary HPV Testing- Screening Intervals- HPV Vaccine Updates- Your PAP and HPV Update 2015 Connie Mao, MD University of Washington Goals Primary HPV Testing- Is it time to stop doing pap smears? Screening Intervals- Should patients have a choice? HPV Vaccine Updates-

More information

Global HPV Vaccine Market: Analysis By End-User (Male, Female), By Age Group (Adolescents, Adults) - By Region, By Country ( )

Global HPV Vaccine Market: Analysis By End-User (Male, Female), By Age Group (Adolescents, Adults) - By Region, By Country ( ) Global HPV Vaccine Market: Analysis By End-User (Male, Female), By Age Group (Adolescents, Adults) - By Region, By Country (2017-2022) By Region- North America, Europe, APAC and RoW By Country - United

More information

PROSPECTS & REALITIES OF PLANT DRUG DEVELOPMENT IN MALAYSIA

PROSPECTS & REALITIES OF PLANT DRUG DEVELOPMENT IN MALAYSIA PROSPECTS & REALITIES OF PLANT DRUG DEVELOPMENT IN MALAYSIA Presented by: Prof. A. N. Rao Editor-in-Chief, Journal of Tropical Medicinal Plants Malaysia 1 2 MALAYSIA Physical Features & Flora West Peninsular

More information

Cervical Cancer Research in South Africa

Cervical Cancer Research in South Africa Gynecologic Cancer InterGroup Cervix Cancer Research Network Cervical Cancer Research in South Africa Lynette Denny Department Obstetrics and Gynaecology, University of Cape Town/ Groote Schuur Hospital

More information

Prevalence of human papillomavirus and Chlamydia trachomatis infection in paired urine and cervical smear samples of Palestinian young women.

Prevalence of human papillomavirus and Chlamydia trachomatis infection in paired urine and cervical smear samples of Palestinian young women. Prevalence of human papillomavirus and Chlamydia trachomatis infection in paired urine and cervical smear samples of Palestinian young women. Walid Salim Basha, PhD Faculty of Human Medicine An-Najah National

More information

How do we compare? IP724/BMTRY Introduction to Global and Public Health. Feb 21, 2012 Basic Science Rm Sharon Bond, PhD, CNM

How do we compare? IP724/BMTRY Introduction to Global and Public Health. Feb 21, 2012 Basic Science Rm Sharon Bond, PhD, CNM Eradicating Cervical Cancer: Our Global Imperative College of Nursing February 2012 What is cervical cancer? Why do we care? 2 nd leading cause of cancer deaths among women worldwide (after breast ca)

More information

Menu and flexibility with the QIAscreen HPV PCR Test

Menu and flexibility with the QIAscreen HPV PCR Test Menu and flexibility with the QIAscreen HPV PCR Test Sample to Insight HPV and Cervical cancer Worldwide, HPV is one of the most common STIs Persistent infection with high-risk HPV types is linked to virtually

More information

Natural History of HPV Infections 15/06/2015. Squamous cell carcinoma Adenocarcinoma

Natural History of HPV Infections 15/06/2015. Squamous cell carcinoma Adenocarcinoma 14,670 5796 United States/ Canada 17,165 8124 Central America 48,328 21,402 South America 59,929 29,814 Europe 78,896 61,670 Africa 157,759 86,708 Southcentral Asia 61,132 31,314 Eastern Asia 42,538 22,594

More information

Background HPV causes virtually all cervical cancers HPV-16, Integration of viral oncogenes E6 and E7 Relationship between HPV and cervical cancer wou

Background HPV causes virtually all cervical cancers HPV-16, Integration of viral oncogenes E6 and E7 Relationship between HPV and cervical cancer wou Case-Control Control Study of Human Papillomavirus avi and Oropharyngeal Cancer D Souza, DSouza, et al. NEJM, May 2007 Tony Sung Julia Beaver Journal Club September 9, 2009 Background HPV causes virtually

More information

GSK Medication: Study No.: Title: Rationale: Phase: Study Period Study Design: Centres: Indication: Treatment: Objectives:

GSK Medication: Study No.: Title: Rationale: Phase: Study Period Study Design: Centres: Indication: Treatment: Objectives: The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.

More information

East Carolina University Continuing Education Courses for Sustainability Symposium

East Carolina University Continuing Education Courses for Sustainability Symposium East Carolina University Continuing Education Courses for 2016-17 2017 Sustainability Symposium Sustainability has emerged as a primary concern for many sectors, including academic institutions and industries

More information

PREVALENCE, ASSOCIATED RISK FACTORS AND METHODS OF DIAGNOSING CERVICAL CANCER IN TWO HOSPITALS IN YAOUNDE, CAMEROON

PREVALENCE, ASSOCIATED RISK FACTORS AND METHODS OF DIAGNOSING CERVICAL CANCER IN TWO HOSPITALS IN YAOUNDE, CAMEROON Available online on www.ijarpb.com Research Article Received on 15/12/2012; Revised on 21/12/2012; Accepted on 23/12/2012 PREVALENCE, ASSOCIATED RISK FACTORS AND METHODS OF DIAGNOSING CERVICAL CANCER IN

More information

Relationship between human papillomavirus infection and cervical cancer progression

Relationship between human papillomavirus infection and cervical cancer progression 21 Review Relationship between human papillomavirus and cervical cancer progression Meichang Ai Infection Management Section, The People's Hospital of Lincang, Lincang, China Keywords Human papillomavirus;

More information

Baseline HPV 2009: A route to evaluation of the HPV vaccination programme

Baseline HPV 2009: A route to evaluation of the HPV vaccination programme Baseline HPV 2009: A route to evaluation of the HPV vaccination programme Dr Sam Hibbitts Senior Lecturer in HPV Department of Obstetrics & Gynaecology School of Medicine Cardiff University Avian Papillomavirus

More information

HPV the silent killer, Prevention and diagnosis

HPV the silent killer, Prevention and diagnosis HPV the silent killer, Prevention and diagnosis HPV Human Papilloma Virus is a name given for a silent virus transmitted sexually most of the time, a virus that spreads in the name of love, passion, and

More information

CERVICAL CANCER A GLOBAL PERSPECTIVE

CERVICAL CANCER A GLOBAL PERSPECTIVE CERVICAL CANCER A GLOBAL PERSPECTIVE Andrés Poveda, MD ACOG, Fundación Instituto Valenciano de Oncología GCIG Chair Cervical Cancer Education Symposium. Mexico, Jan 2017 Gynecological Cancer Gynecological

More information

Yuanyuan Wang, 1 Shaohong Wang, 1 Jinhui Shen, 1 Yanyan Peng, 2 Lechuan Chen, 2 Ruiqin Mai, 3 and Guohong Zhang Introduction

Yuanyuan Wang, 1 Shaohong Wang, 1 Jinhui Shen, 1 Yanyan Peng, 2 Lechuan Chen, 2 Ruiqin Mai, 3 and Guohong Zhang Introduction BioMed Volume 2016, Article ID 1256384, 6 pages http://dx.doi.org/10.1155/2016/1256384 Research Article Genotype Distribution of Human Papillomavirus among Women with Cervical Cytological Abnormalities

More information

Correlation of HPV Types in Archived ASCUS Samples

Correlation of HPV Types in Archived ASCUS Samples Correlation of HPV Types in Archived ASCUS Samples Sharon Wah-Suet NG 1, Stephen Tsui-Hoi Lo 2, Daniel Chuen-Chu TAM 1 1 Genepath Technology Limited 2 Molecular Pathology Laboratory, Department of Pathology,

More information

JMSCR Volume 03 Issue 01 Page January 2015

JMSCR Volume 03 Issue 01 Page January 2015 www.jmscr.igmpublication.org Impact Factor 3.79 ISSN (e)-2347-176x Seroprevalence of HBV among HIV Patients and Blood Donors Author Dr. Vedavati B I 1, Dr. Amrutha Kumari B 2, Dr. Venkatesha D 3 Mysore

More information

Enterobacteriaceae with acquired carbapenemases, 2015

Enterobacteriaceae with acquired carbapenemases, 2015 Enterobacteriaceae with acquired carbapenemases, 2015 Background The acquired or transferable (as opposed to chromosomally encoded) carbapenemases found in Enterobacteriaceae belong to three of the four

More information

CERVICAL CANCER SCREENING IN BOTSWANA: A ROLE FOR TELEMEDICINE A. STATEMENT OF HYPOTHESIS AND SPECIFIC AIMS

CERVICAL CANCER SCREENING IN BOTSWANA: A ROLE FOR TELEMEDICINE A. STATEMENT OF HYPOTHESIS AND SPECIFIC AIMS CERVICAL CANCER SCREENING IN BOTSWANA: A ROLE FOR TELEMEDICINE A. STATEMENT OF HYPOTHESIS AND SPECIFIC AIMS A.1. Introduction Women in sub-saharan Africa often present with advanced stages of cervical

More information

Objectives. Background. Background. Background. Background 9/26/16. Update on Cervical and HPV Screening Guidelines: To pap or not to pap?

Objectives. Background. Background. Background. Background 9/26/16. Update on Cervical and HPV Screening Guidelines: To pap or not to pap? Update on Cervical and HPV Screening Guidelines: To pap or not to pap? Marina Delazari Miller MD Clinical Assistant Professor Department of Obstetrics & Gynecology University of Iowa Hospitals and Clinics

More information

Tuesday 15 January 2013 Afternoon

Tuesday 15 January 2013 Afternoon Tuesday 15 January 2013 Afternoon AS GCE HUMAN BIOLOGY F222/01/TEST Growth, Development and Disease *F210760113* Candidates answer on the Question Paper. OCR supplied materials: Advance Notice (inserted)

More information

Type-Specific Incidence and Persistence of HPV Infection among Young Women: A Prospective Study in North India

Type-Specific Incidence and Persistence of HPV Infection among Young Women: A Prospective Study in North India DOI:http://dx.doi.org/10.7314/APJCP.2012.13.3.1019 Type-Specific Incidence and Persistence of HPV Infection among Young Women in North India RESEARCH COMMUNICATION Type-Specific Incidence and Persistence

More information

Clinical Policy Title: Fluorescence in situ hybridization for cervical cancer screening

Clinical Policy Title: Fluorescence in situ hybridization for cervical cancer screening Clinical Policy Title: Fluorescence in situ hybridization for cervical cancer screening Clinical Policy Number: 01.01.02 Effective Date: April 1, 2015 Initial Review Date: January 21, 2015 Most Recent

More information

Focus. International #52. HPV infection in High-risk HPV and cervical cancer. HPV: Clinical aspects. Natural history of HPV infection

Focus. International #52. HPV infection in High-risk HPV and cervical cancer. HPV: Clinical aspects. Natural history of HPV infection HPV infection in 2014 Papillomaviruses (HPV) are non-cultivable viruses with circular DNA. They can establish productive infections in the skin (warts) and in mucous membranes (genitals, larynx, etc.).

More information

HPV-Negative Results in Women Developing Cervical Cancer: Implications for Cervical Screening Options

HPV-Negative Results in Women Developing Cervical Cancer: Implications for Cervical Screening Options HPV-Negative Results in Women Developing Cervical Cancer: Implications for Cervical Screening Options R. Marshall Austin MD,PhD Magee-Womens Hospital of University of Pittsburgh Medical Center (UPMC) (raustin@magee.edu)

More information

Diagnosi di HPV: I dati mondiali ed europei Convegno Nazionale GISCi, Orvieto Silvia Franceschi

Diagnosi di HPV: I dati mondiali ed europei Convegno Nazionale GISCi, Orvieto Silvia Franceschi Diagnosi di HPV: I dati mondiali ed europei Convegno Nazionale GISCi, Orvieto 2008 Silvia Franceschi International Agency for Research on Cancer 150 cours Albert Thomas 69372 Lyon France La mia presentazione

More information

1. Patterns of disclosure of HIV diagnosis to adolescents/ children: A facility based exploratory study

1. Patterns of disclosure of HIV diagnosis to adolescents/ children: A facility based exploratory study 1. Patterns of disclosure of HIV diagnosis to adolescents/ children: A facility based exploratory study Principal Investigator Other Investigator(s): Dr. Seema Sahay, NARI Mrs. N. Joglekar, Mrs. R. Brahme,

More information

Clinical Relevance of HPV Genotyping. A New Dimension In Human Papillomavirus Testing. w w w. a u t o g e n o m i c s. c o m

Clinical Relevance of HPV Genotyping. A New Dimension In Human Papillomavirus Testing. w w w. a u t o g e n o m i c s. c o m Clinical Relevance of HPV Genotyping A New Dimension In Human Papillomavirus Testing Human Papillomavirus: Incidence HPV prevalence was 26.8% for women in US aged 14 59 yrs 1 20 million Americans are currently

More information

Summary Dose Schedule 2. 9HPV vaccine 3. Primary HPV screening 4. Male vaccination 5. Update on Australia 6. Natural History 7.

Summary Dose Schedule 2. 9HPV vaccine 3. Primary HPV screening 4. Male vaccination 5. Update on Australia 6. Natural History 7. Summary 1. 2 Dose Schedule 2. 9HPV vaccine 3. Primary HPV screening 4. Male vaccination 5. Update on Australia 6. Natural History 7. OPC and Anal 2 dose schedules The train has left the station 2 dose

More information

Risk factors for precancerous lesions of the cervix in a population of Georgian women

Risk factors for precancerous lesions of the cervix in a population of Georgian women Training Course in Sexual and Reproductive Health Research Geneva, 2 March 2009 Risk factors for precancerous lesions of the cervix in a population of Georgian women Maia Chiokadze, M.D. Medical Diagnostic

More information

Study No.: Title: Rationale: Phase: Study Period: Study Design: Centers: Indication: Treatment: Objectives: Primary Outcome/Efficacy Variable:

Study No.: Title: Rationale: Phase: Study Period: Study Design: Centers: Indication: Treatment: Objectives: Primary Outcome/Efficacy Variable: The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.

More information

International Journal of Pharma and Bio Sciences DETECTION OF HEPATITIS B SURFACE ANTIGEN USING ELISA AND REAL TIME PCR ABSTRACT

International Journal of Pharma and Bio Sciences DETECTION OF HEPATITIS B SURFACE ANTIGEN USING ELISA AND REAL TIME PCR ABSTRACT Research Article Biotechnology International Journal of Pharma and Bio Sciences ISSN 0975-6299 DETECTION OF HEPATITIS B SURFACE ANTIGEN USING ELISA AND REAL TIME PCR ALI MOHAMMED ABDUL MOHSEN Indian academy

More information

Know for sure! Your Power for Health. PapilloCheck and PapilloCheck high-risk HPV-Genotyping: The Clear Edge in Early Detection of Cervical Cancer.

Know for sure! Your Power for Health. PapilloCheck and PapilloCheck high-risk HPV-Genotyping: The Clear Edge in Early Detection of Cervical Cancer. Your Power for Health Laboratory Information hr-hpv DNA-Chip Know for sure! PapilloCheck and PapilloCheck high-risk HPV-Genotyping: The Clear Edge in Early Detection of Cervical Cancer. PapilloCheck and

More information

Viral and Host Factors in Vulvar Disease DR MICHELLE ETHERSON 26 TH OF APRIL 2016

Viral and Host Factors in Vulvar Disease DR MICHELLE ETHERSON 26 TH OF APRIL 2016 Viral and Host Factors in Vulvar Disease DR MICHELLE ETHERSON 26 TH OF APRIL 2016 Human Papillomavirus (HPV) Small non-enveloped Double stranded DNA Virus Genome 8000 basepairs 8 coding genes, Early (E)

More information

Title: Seroprevalence of Human Papillomavirus Types 6, 11, 16 and 18 in Chinese Women

Title: Seroprevalence of Human Papillomavirus Types 6, 11, 16 and 18 in Chinese Women Author's response to reviews Title: Seroprevalence of Human Papillomavirus Types 6, 11, 16 and 18 in Chinese Women Authors: Jia Ji (jackie.j.ji@gmail.com) He Wang (hewangpeking@gmail.com) Jennifer S. Smith

More information

HPV is the most common sexually transmitted infection in the world.

HPV is the most common sexually transmitted infection in the world. Hi. I m Kristina Dahlstrom, an instructor in the Department of Head and Neck Surgery at The University of Texas MD Anderson Cancer Center. My lecture today will be on the epidemiology of oropharyngeal

More information

STOCS-H Scottish TOC Study HPV test comparison

STOCS-H Scottish TOC Study HPV test comparison STOCS-H Scottish TOC Study HPV test comparison What is entailed? Trial of new HPV tests on residual sample after HC2 result obtained, reported and acted on Complements English Sentinel Sites HPV Multi-test

More information

MOLECULAR ANALYSIS OF A SERIES OF ACRAL MELANOMAS IN SINGAPORE

MOLECULAR ANALYSIS OF A SERIES OF ACRAL MELANOMAS IN SINGAPORE MOLECULAR ANALYSIS OF A SERIES OF ACRAL MELANOMAS IN SINGAPORE PoYin Tan Inny Busmanis Dept of Anatomical Pathology, Lynette Oon Head, Molecular Lab Singapore General Hospital ETHNIC GROUPS IN SINGAPORE

More information

Liver Cancer Causes, Risk Factors, and Prevention

Liver Cancer Causes, Risk Factors, and Prevention Liver Cancer Causes, Risk Factors, and Prevention Risk Factors A risk factor is anything that affects your chance of getting a disease such as cancer. Learn more about the risk factors for liver cancer.

More information

National Cervical Screening Program MBS Item Descriptors

National Cervical Screening Program MBS Item Descriptors National Cervical Screening Program MBS Item Descriptors Item Item descriptor 73070 A test, including partial genotyping, for oncogenic human papillomavirus that may be associated with cervical pre-cancer

More information

Molecular Diagnosis Future Directions

Molecular Diagnosis Future Directions Molecular Diagnosis Future Directions Philip Cunningham NSW State Reference Laboratory for HIV/AIDS & Molecular Diagnostic Medicine Laboratory, SydPath St Vincent s Hospital Sydney Update on Molecular

More information

Hosp Lab Management (HLM) Service. HLM Tie-ups Cervical Screening & Diagnostics Tie-up Business Process Flow

Hosp Lab Management (HLM) Service. HLM Tie-ups Cervical Screening & Diagnostics Tie-up Business Process Flow Hosp Lab Management (HLM) Service HLM Tie-ups Cervical Screening & Diagnostics Tie-up Business Process Flow Women s Healthcare: Demography End of uncertainties Actual Disease Burden: Delhi NCR: FY2012-13

More information

Molecular Diagnostics Market Share, Size, Analysis, Growth, Trends and Forecasts, 2016 to 2024 Hexa Research

Molecular Diagnostics Market Share, Size, Analysis, Growth, Trends and Forecasts, 2016 to 2024 Hexa Research Molecular Diagnostics Market Share, Size, Analysis, Growth, Trends and Forecasts, 2016 to 2024 Hexa Research " Projected to grow at a CAGR of almost 9% from 2016 to 2024, the molecular diagnostics market

More information

The clearest path to the most meaningful results. The cobas HPV Test delivers clinical value with workflow efficiencies every step of the way

The clearest path to the most meaningful results. The cobas HPV Test delivers clinical value with workflow efficiencies every step of the way The clearest path to the most meaningful results The cobas HPV Test delivers clinical value with workflow efficiencies every step of the way The cobas HPV Test KNOW THE RISK Help guide clinical decision

More information

THE PERFORMANCE OF CEPHEID XPERT HPV

THE PERFORMANCE OF CEPHEID XPERT HPV THE PERFORMANCE OF CEPHEID XPERT HPV Zizipho Z.A Mbulawa, Timothy Wilkin, Bridgette J. Goeieman, Eefje Jong, Pamela Michelow, Avril Swarts, Jennifer S. Smith, Patricia Kegorilwe, Cynthia S. Firnhaber,

More information

Study Number: Title: Rationale: Phase: Study Period Study Design: Centres: Indication Treatment: Objectives: Primary Outcome/Efficacy Variable:

Study Number: Title: Rationale: Phase: Study Period Study Design: Centres: Indication Treatment: Objectives: Primary Outcome/Efficacy Variable: The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.

More information

HPV Transmission. Rachel Winer, PhD, MPH Department of Epidemiology University of Washington

HPV Transmission. Rachel Winer, PhD, MPH Department of Epidemiology University of Washington HPV Transmission Rachel Winer, PhD, MPH Department of Epidemiology University of Washington rlw@u.washington.edu Disclosure Information I have no financial relationships to disclose. Human Papillomavirus

More information

Cervical Cancer Screening. David Quinlan December 2013

Cervical Cancer Screening. David Quinlan December 2013 Cervical Cancer Screening David Quinlan December 2013 Cervix Cervical Cancer Screening Modest variation provincially WHO and UK begin at 25 stop at 60 Finland begin at 30 stop at 60 Rationale for

More information

Making Sense of Cervical Cancer Screening

Making Sense of Cervical Cancer Screening Making Sense of Cervical Cancer Screening New Guidelines published November 2012 Tammie Koehler DO, FACOG The incidence of cervical cancer in the US has decreased more than 50% in the past 30 years because

More information

Human Papillomaviruses: Biology and Laboratory Testing

Human Papillomaviruses: Biology and Laboratory Testing For our patients and our population Human Papillomaviruses: Biology and Laboratory Testing Geoffrey Higgins Microbiology and Infectious Diseases For our patients and our population HPV Associated Cancers

More information

Knowledge, Attitudes and Practices Regarding Cervical Cancer and Screening among Haitian Health Care Workers. KAP Survey

Knowledge, Attitudes and Practices Regarding Cervical Cancer and Screening among Haitian Health Care Workers. KAP Survey Supplementary Information Knowledge, Attitudes and Practices Regarding Cervical Cancer and Screening among Haitian Health Care Workers KAP Survey Healthcare Provider Survey about Cervical Cancer Thank

More information

Copyright. Not for Sale or Commercial Distribution

Copyright. Not for Sale or Commercial Distribution World Congress of Gynecology and Obstetrics (FIGO), Cape Town, South Africa, October 4-9, 2009 Focusing on new research presented on Human Papillomavirus and Cervical Cancer On-site Canadian Ambassadors

More information

The introduction of HPV testing to cervical screening in Scotland

The introduction of HPV testing to cervical screening in Scotland The introduction of HPV testing to cervical screening in Scotland Frequently asked questions for professionals Key messages From early 2020, cervical cytology (looking at cells under a microscope) will

More information

Bottoms UP HIV and Anal Cancer from Screening to Prevention

Bottoms UP HIV and Anal Cancer from Screening to Prevention Bottoms UP HIV and Anal Cancer from Screening to Prevention Paul MacPherson PhD, MD, FRCPC Associate Professor Division of Infectious Diseases University of Ottawa The New Reality Normal or near-normal

More information

Human Papillomavirus Genotype Distribution in Cervical Cancer in India: Results from a Multi-center Study

Human Papillomavirus Genotype Distribution in Cervical Cancer in India: Results from a Multi-center Study Human Papillomavirus Genotype Distribution in Cervical Cancer in India RESEARCH COMMUNICATION Human Papillomavirus Genotype Distribution in Cervical Cancer in India: Results from a Multi-center Study Partha

More information

ARTICLES. Worldwide Human Papillomavirus Etiology of Cervical Adenocarcinoma and Its Cofactors: Implications for Screening and Prevention

ARTICLES. Worldwide Human Papillomavirus Etiology of Cervical Adenocarcinoma and Its Cofactors: Implications for Screening and Prevention ARTICLES Worldwide Human Papillomavirus Etiology of Cervical Adenocarcinoma and Its Cofactors: Implications for Screening and Prevention Xavier Castellsagué, Mireia Díaz, Silvia de Sanjosé, Nubia Muñoz,

More information

A Case Control Study of HPV and Abnormal Cervical Cytology Among HIV Infected and Non Infected Females

A Case Control Study of HPV and Abnormal Cervical Cytology Among HIV Infected and Non Infected Females A Case Control Study of HPV and Abnormal Cervical Cytology Among HIV Infected and Non Infected Females Kavita Karmacharya 1, Rajiv B Batra 2 and Subramaniam Kandasamy 3 1: Department of Pathology, Nepalese

More information

CHAPTER FOUR: UPDATE ON THE AIDS PANDEMIC TABLE 2 MILESTONES IN THE HISTORY OF HIV/AIDS TABLE 2 (CONTINUED) REGIONAL OVERVIEW...

CHAPTER FOUR: UPDATE ON THE AIDS PANDEMIC TABLE 2 MILESTONES IN THE HISTORY OF HIV/AIDS TABLE 2 (CONTINUED) REGIONAL OVERVIEW... CHAPTER ONE: INTRODUCTION... 1 STUDY GOALS AND OBJECTIVES... 1 REASONS FOR DOING THE STUDY... 1 SCOPE OF REPORT... 1 MARKET ANALYSES AND FORECASTS... 2 INTENDED AUDIENCE... 2 INFORMATION SOURCES... 2 ANALYST

More information

Why HPV Screening Which Problems What Methods

Why HPV Screening Which Problems What Methods Lead Group Log HPV Testing & Screening Current Status & Future Screening HPV Andreas M. Kaufmann Why HPV Screening Which Problems What Methods Andreas M. Kaufmann Gynecologic Tumor Immunology Charité Campus

More information

INTRODUCTION HUMAN PAPILLOMAVIRUS

INTRODUCTION HUMAN PAPILLOMAVIRUS INTRODUCTION HUMAN PAPILLOMAVIRUS Professor Anna-Lise Williamson Institute of Infectious Disease and Molecular Medicine, University of Cape Town National Health Laboratory Service, Groote Schuur Hospital

More information

- ii - Rights c

- ii - Rights c - ii - Rights c - iii - Preface Preface to the third edition Since the first edition of the HPV Information Centre, GLOBOCAN, one of the landmark products of the International Agency for Research on Cancer

More information

Shareholder Presentation Annual Meeting 2018

Shareholder Presentation Annual Meeting 2018 Shareholder Presentation Annual Meeting 2018 FY 18 HIGHLIGHTS Strong sales growth of 2 nd Gen TruScreen to China commenced during 4 th quarter. (50% of the year s sales were generated in the fourth quarter)

More information

Human papillomavirus and vaccination for cervical cancer

Human papillomavirus and vaccination for cervical cancer Human papillomavirus and vaccination for cervical cancer Dorothy Machalek Department of Microbiology and Infectious Diseases Royal Women s Hospital, Melbourne, Australia VIRUSES AND CANCER Responsible

More information

HBV in New Zealand Community HBV screening to long-term follow-up

HBV in New Zealand Community HBV screening to long-term follow-up HBsAg+ icteric hepatitis (n) % anti-hbcore+ 26/9/214 HBV in New Zealand Community HBV screening to long-term follow-up John Hornell, CEO, A registered charitable trust whose mission is: To improve health

More information

HPV Knowledge Survey Healthcare Providers

HPV Knowledge Survey Healthcare Providers 1. What is your age? m 20-24 m 25-35 m 36-45 m 46-55 m 56-65 m 66-75 2. What is your gender? m Male m Female m Other 3. Which ethnic group do you identify with (please tick all that apply)? m New Zealand

More information

Short Communication. Department of Pathology, General University Hospital of Valencia, Valencia, Spain

Short Communication. Department of Pathology, General University Hospital of Valencia, Valencia, Spain Short Communication Comparison of the prevalence and distribution of human papillomavirus infection and cervical lesions between urban and native habitants of an Amazonian region of Peru M. Martorell 1,

More information

RESEARCH ARTICLE. Yue-Yun Wang 1, Li Li 2, Sheng Wei 2, Ji Peng 3, Shi-Xin Yuan 1, Jian-Sheng Xie 1, Zhi-Hua Liu 1 * Abstract.

RESEARCH ARTICLE. Yue-Yun Wang 1, Li Li 2, Sheng Wei 2, Ji Peng 3, Shi-Xin Yuan 1, Jian-Sheng Xie 1, Zhi-Hua Liu 1 * Abstract. RESEARCH ARTICLE Human Papillomavirus (HPV) Infection in Women Participating in Cervical Cancer Screening from 2006 to 2010 in Shenzhen City, South China Yue-Yun Wang 1, Li Li 2, Sheng Wei 2, Ji Peng 3,

More information

CANCER FACT SHEETS: LIVER CANCER

CANCER FACT SHEETS: LIVER CANCER CANCER FACT SHEETS: LIVER CANCER Estimated age-standardised rates (World) in the world (per 100 000) At a glance China WHO Western Pacific Region Less developed regions World WHO African Region United

More information

Comparison of an optoelectronic scan of the cervix, cervical cytology and HPV genotyping for CIN screening

Comparison of an optoelectronic scan of the cervix, cervical cytology and HPV genotyping for CIN screening Comparison of an optoelectronic scan of the cervix, cervical cytology and HPV genotyping for CIN screening Ricardo Lúa Alvarado President of Occident Colposcopy and Genital Pathology College Professor

More information

This online (electronic) survey contains twenty four simple questions. Those marked with an asterisk (*) must be answered.

This online (electronic) survey contains twenty four simple questions. Those marked with an asterisk (*) must be answered. 1. Type of survey This is a retrospective survey that will NOT require the disclosure of any individual patient records or data only information about overall EGFR mutation testing practices and the outcomes

More information

birthplace and length of time in the US:

birthplace and length of time in the US: Cervical cancer screening among foreign-born versus US-born women by birthplace and length of time in the US: 2005-2015 Meheret Endeshaw, MPH CDC/ASPPH Fellow Division Cancer Prevention and Control Office

More information

HIV/AIDS Perinatal Surveillance Minnesota Department of Health HIV/AIDS Surveillance System

HIV/AIDS Perinatal Surveillance Minnesota Department of Health HIV/AIDS Surveillance System HIV/AIDS Perinatal Surveillance 2012 Minnesota Department of Health HIV/AIDS Surveillance System Background This slide set describes births to HIV-infected women in Minnesota by person, place, and time.

More information

Chapter 8. Summary. Chapter 8. Summary

Chapter 8. Summary. Chapter 8. Summary Chapter 8 Chapter 8 Summary Summary Summary In CHAPTER 1 an introduction to several aspects of cervical cancer, HPV and their relation with immunology is given. It took almost one-and-a-half centuries

More information

Trends in HPV-Associated Cancers United States,

Trends in HPV-Associated Cancers United States, National Center for Chronic Disease Prevention and Health Promotion Trends in HPV-Associated Cancers United States, 1999 2014 Elizabeth A. Van Dyne, MD, MPH Division of Cancer Prevention and Control Epidemiology

More information

K Cuschieri, Scottish HPV Reference Lab Presented at SMVN Laboratories and Specialised Services Meeting, March 2013

K Cuschieri, Scottish HPV Reference Lab Presented at SMVN Laboratories and Specialised Services Meeting, March 2013 Scottish HPV Reference Lab K Cuschieri, Scottish HPV Reference Lab Presented at SMVN Laboratories and Specialised Services Meeting, March 2013 About us Established 2008 Based at RIE Team of 7 Functions

More information

Cytology Update M Laing QEUH

Cytology Update M Laing QEUH Cytology Update M Laing QEUH Age change to 25 to 65 Age 25 to 50 Three yearly smear invitation Age 50 to 65 Five yearly smear invitation Women on non routine screening will be invited up to age 70 OUTCOME

More information

CERVARIX GlaxoSmithKline

CERVARIX GlaxoSmithKline CERVARIX GlaxoSmithKline International Data Sheet. Version 2 (31/01/2007) Cervarix 1. Name of the medicinal product CervarixTM Human Papillomavirus vaccine Types 16 and 18 (Recombinant, AS04 adjuvanted).

More information

In 2013, around 12.9 million people living with HIV had access to antiretroviral therapy.

In 2013, around 12.9 million people living with HIV had access to antiretroviral therapy. F A C T S H E E T 2014 GLOBAL STATISTICS People living with HIV In 2013, there were 35 [33.2 37.2 ] people living with HIV. - Since the start of the epidemic, around 78 [71 87 ] people have become infected

More information

Smoking, human papillomavirus infection, and p53 mutation as risk factors in oropharyngeal cancer: a case-control study

Smoking, human papillomavirus infection, and p53 mutation as risk factors in oropharyngeal cancer: a case-control study RESEARCH FUND FOR THE CONTROL OF INFECTIOUS DISEASES Smoking, human papillomavirus infection, and p53 as risk factors in oropharyngeal cancer: a case-control study PKS Chan *, JSY Chor, AC Vlantis, TL

More information

The Korean Journal of Cytopathology 15 (1) : 17-27, 2004

The Korean Journal of Cytopathology 15 (1) : 17-27, 2004 5 The Korean Journal of Cytopathology 5 () : 7-7, / 5 / / (human papillomavirus, HPV), 6%, 5% HPV. HPV HPV. HPV HPV,,5 HPV HPV. HPV, 6 HPV. HPV HPV International Agency for Research on Cancer (IARC) HPV

More information

Tuberculosis-related deaths in people living with HIV have fallen by 36% since 2004.

Tuberculosis-related deaths in people living with HIV have fallen by 36% since 2004. F A C T S H E E T 2014 GLOBAL STATISTICS People living with HIV In 2013, there were 35 [33.2 37.2 ] people living with HIV. - Since the start of the epidemic, around 78 [71 87 ] people have become infected

More information

An increasing demand for livestock directly translates into increasing demand for animal feed and animal

An increasing demand for livestock directly translates into increasing demand for animal feed and animal An increasing demand for livestock directly translates into increasing demand for animal feed and animal feed additives such as vitamins. Synthetic vitamin E is the key ingredient used in global animal

More information

Human papillomavirus-type distribution in South African women without cytological abnormalities: a peri-urban study

Human papillomavirus-type distribution in South African women without cytological abnormalities: a peri-urban study Human papillomavirus-type distribution in South African women without cytological abnormalities: a peri-urban study Van Aardt MC, FCOG (SA), MMed(O&G), MBChB, Research Fellow, Gynaecological Oncology Dreyer

More information

WASHINGTON STATE COMMUNICABLE DISEASES OF PUBLIC HEALTH SIGNIFICANCE FOR THE CIVIL SURGEON

WASHINGTON STATE COMMUNICABLE DISEASES OF PUBLIC HEALTH SIGNIFICANCE FOR THE CIVIL SURGEON WASHINGTON STATE COMMUNICABLE DISEASES OF PUBLIC HEALTH SIGNIFICANCE FOR THE CIVIL SURGEON SCOTT LINDQUIST MD MPH WASHINGTON STATE DEPARTMENT OF HEALTH STATE EPIDEMIOLOGIST FOR COMMUNICABLE DISEASES FOREIGN-BORN

More information

Segment Coverage By Type By Age Group. Global Coverage Regional Coverage Country Coverage

Segment Coverage By Type By Age Group. Global Coverage Regional Coverage Country Coverage Global Cervical Cancer Diagnostics Market By Type (Pap Testing, HPV Testing, Colposcopy and Cervical Biopsies), By Age Group (35 years): Forecast to 2022 By Type - Pap Test, HPV Test,

More information

Why HPV surveillance and why is HPV special?

Why HPV surveillance and why is HPV special? Monitoring of Human Papillomavirus vaccination Joakim Dillner Professor of Infectious Disease Epidemiology Depts. of Laboratory Medicine, Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm,

More information

Cervical Cancer Prevention in Low-resource Countries: Is a Comprehensive Approach Possible?

Cervical Cancer Prevention in Low-resource Countries: Is a Comprehensive Approach Possible? Cervical Cancer Prevention in Low-resource Countries: Is a Comprehensive Approach Possible? Vivien Tsu, PhD, MPH PATH, Seattle VIDI Symposium, FHCRC, Seattle January 14, 2008 Overview 1. Background on

More information

Diphtheria infections caused by the different toxigenic biotypes of Corynebacterium diphtheriae

Diphtheria infections caused by the different toxigenic biotypes of Corynebacterium diphtheriae JCM Accepts, published online ahead of print on 5 December 00 J. Clin. Microbiol. doi:0.8/jcm.054-0 Copyright 00, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

More information

SIRveNIB Study Data Presented at ASCO Annual Meeting

SIRveNIB Study Data Presented at ASCO Annual Meeting ASX/MEDIA RELEASE 5 th June 2017 SIRveNIB Study Data Presented at ASCO Annual Meeting Sydney, Australia; 5 th June 2017 Sirtex Medical Limited (ASX:SRX) announces the oral abstract of the SIRveNIB clinical

More information

National Cervical Screening Programme. Annual Report 2014

National Cervical Screening Programme. Annual Report 2014 National Cervical Screening Programme Annual Report 2014 Report prepared February 2017 Revised May 2017 Finalised June 2017 Report prepared by Megan Smith, Leanne Rumlee and Karen Canfell. Cancer Research

More information