Gifu University Graduate School of Medicine, Gifu Asahi University School of Dentistry, Gifu Sakihai Institute, Gifu

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1 Chisato NAGATA, Naoyoshi TAKATSUKA, Noriyuki TAKEDA 2 and Hiroyuki SHIMIZU 3 Gifu University Graduate School of Medicine, Gifu Asahi University School of Dentistry, Gifu Sakihai Institute, Gifu ABSTRACT The present study prospectively examined the association between soy intake and cedar pollen allergy, asthma, and allergic dermatitis in a community in Japan. Diet including soy intake was determined using a validated 69-item food-frequency questionnaire at the baseline. Information about experience with cedar pollinosis and history of doctor-diagnosed asthma and allergic dermatitis was collected about 0 years later using a questionnaire. The risks of cedar pollen allergy, asthma, and allergic dermatitis according to tertile of soy product or soy isoflavone intake were estimated using Cox hazard model or logistic model including age and smoking status at baseline as covariates. The association between soy intake and the risk of cedar pollinosis was nearly null in both men and women. There was no significant association between soy intake and risk of asthma. A significantly decreased risk of allergic dermatitis was observed in the second tertile of soy intake in men, although the trend was not statistically significant. Similar tendency was observed in women. Soy Protein Research, Japan 0, -5, Key words : soy, cedar pollinosis, asthma, allergic dermatitis, prospective study

2 5 20% 24.5% ) ,552 4,427 7, , % ,966 4) IgE ,975 25, % 2,23 Willett,00 Fig. Fig.2 body mass index 2

3 5 7),002 5, ) 8) 9) 5.3% 0.05% 0) lifetime prevalence 4.3% ) RR (Low) (High) Total soy products Soy isoflavones Fig. -. Relative risk of cedar pollinosis according to tertile of soy intake in men. RR (Low) (High) Total soy products Soy isoflavones Fig. -2. Relative risk of cedar pollinosis according to tertile of soy intake in women. 3

4 Asthma Allergic dermatitis (Low) (High) Fig. 2-. Odds ratio of asthma and allergic dermatitis according to tertile of soy isoflavone intake in men. Asthma Allergic dermatitis (Low) (High) Fig Odds ratio of asthma and allergic dermatitis according to tertile of soy isoflavone intake in women

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