Diagnosis and management of helminth infections

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1 Drug review Worms Diagnosis and management of helminth infections William Newsholme MSc, MRCP, DTM&H Skyline Imaging Ltd A number of worm infections are seen in the UK, mostly acquired through foreign travel or found in immigrants. Our Drug review discusses currently recommended treatments, followed by sources of further information and a Datafile of licensed drugs. Helminth infections in both gut and tissue are major causes of morbidity in all age groups in the developing world. Up to one billion individuals worldwide are infected with hookworm and Ascaris, and 200 million with schistosomiasis. In the developed world, due to improvements in hygiene and food safety, local transmission of infection is much less frequent, though infections such as Enterobius remain common. However, with the increase in international travel, migration and more adventurous culinary behaviour, unusual helminth infections may be encountered anywhere. Worldwide it is nematodes, or roundworms, that cause the bulk of infection. The intestinal helminths Ascaris, hookworm, Trichuris and Strongyloides are good markers at a population level of poor hygiene and general deprivation, and cause growth and educational impairment in children and anaemia in pregnancy. Filaria infect about 100 million worldwide but are rare in travellers. Tissue helminths, such as Trichinella, may become more frequent with increasing travel and 24 Prescriber 5 August

2 dietary adventure. The same is true for the lung and intestinal trematodes, or flukes. Schistosomiasis is a well-recognised infection in migrants and travellers from sub-saharan Africa. The tapeworms, or cestodes, are found worldwide and again depend on dietary exposure for transmission. Neurocysticercosis, now recognised as a leading cause of epilepsy in the developing world, is being seen with increasing incidence in travellers. In general helminths are unable to complete their life-cycle in humans, and thus one of the major determinants of pathology is the number of worms infecting the host, the worm load. Most people receive a relatively small worm load, and for this reason the majority of UK-born individuals with worm infection will be relatively symptom free due to short-lived exposures while overseas, and will often only discover infection by chance on routine screening or on passing a worm in the stool. Classic helminth disease will be seen more commonly in migrants, those visiting families overseas and individuals such as aid-workers who have more prolonged exposure. However, failure to obtain a travel history may mean that helminth infection is not considered in individuals presenting with problems such as anaemia. Epidemiological data in the UK is difficult to interpret due to poor levels of disease reporting to the Health Protection Agency (HPA). However, screening of antenatal clinic attendees suggests around 10 per cent of women from the Indian subcontinent may be carrying intestinal helminths, with up to 45 per cent of Bangladeshi women harbouring infection, the majority being hookworm and Trichuris. The gut helminths The majority of individuals with gut helminths will be relatively asymptomatic, though a variety of symptoms may be attributable to the helminth infection (see Tables 1 and 2). Infection may be discovered incidentally when investigation for symptoms such as bronchospasm or epilepsy are undertaken. Eosinophilia is rare with cestode infection but is commonly seen with trematode and nematode infection. Ascaris lumbricoides (common roundworm, see Figure 1) Over one billion people and up to 50 per cent of school-age children are thought to be infected with Ascaris worldwide, with a higher prevalence in warmer countries. About 100 cases are reported to the HPA annually, the majority appearing to be contracted in the Indian subcontinent, but an accurate travel history is often not reported. Infection is by Gastrointestinal epigastric pain diarrhoea (see Table 2) malabsorption states appendicitis right iliac fossa pain/mass pruritus ani rectal prolapse bowel obstruction/volvulus biliary obstruction/ cholangitis Systemic anaemia eosinophilia fever cardiac failure bronchospasm pneumonitis septicaemia epilepsy dermatological manifestations, eg urticaria Table 1. Signs and symptoms of infection associated with gastrointestinal helminths accidental ingestion of eggs, with a larval migratory phase through the lungs that may cause a transient pneumonitis. Infection is often discovered when adult worms are passed per rectum or vomited. Worms are 15-35cm in length and white to brown in colour, looking not unlike earthworms. Large worm burdens may cause malabsorption syndromes, but the most severe disease manifestations occur when worms migrate into the biliary tree causing cholangitis, or become caught in the appendix or plug a section of bowel causing obstruction, intussusception or volvulus. Trichinella spiralis (roundworm) Trichinella is acquired from ingestion of infested pork or boar. There has been no domestic infection in the UK since 1969, but sporadic outbreaks occur from imported foodstuffs, especially poorly cured pork sausages. Only a small proportion of cases become symptomatic. Disease initially manifests with a fever and diarrhoea at the time of gut invasion. Several weeks later tissue invasion causing fever, myalgia, eosinophilia and periorbital oedema may be seen. Sometimes myocardial, pulmonary and CNS disease can occur, which may be fatal. Enterobius vermicularis (threadworm) This is the most common gut helminth in the UK, especially among school-age children; childhood Not associated with Possibly causing Definitely causing diarrhoea diarrhoea diarrhoea Enterobius vermicularis hookworm species Trichuris trichiura Ascaris lumbricoides Hymenolepis nana Strongyloides stercoralis Taenia species Diphyllobothrium latum Schistosoma species Trichinella spiralis Table 2. Gastrointestinal helminths and diarrhoea Prescriber 5 August

3 syndrome than that seen with Ascaris, sometimes lasting several months. Adult worms live in the small gut for up to a decade, taking blood meals of up to 0.25g per day, and can produce an iron-deficiency anaemia in three to five months in populations such as pregnant women. Hypoproteinaemic states, diarrhoea and abdominal pain may also be seen. Dog hookworms have been associated with eosinophilic enteritis in Australia. Figure 1. Ascaris lumbricoides or common roundworm large worm loads may cause malabsorption syndromes prevalence may be up to 50 per cent. It has no cultural or socioeconomic associations. Infection is by accidental ingestion of eggs, which may persist for several weeks in the environment allowing ongoing transmission within families and institutions. Adult female worms migrate to the anal margin to deposit eggs, giving the characteristic symptom of nocturnal perianal itch. Ectopic worm migration may give rise to vaginal infection, which may be associated with recurrent urinary tract infections (UTIs). In some studies up to 36 per cent of young females with UTI have been found to be co-infected with threadworm. Reinfection from fingers and contaminated objects (fomites), such as bedding, is easy. A third of infections are asymptomatic and lab tests are almost always normal. Relapsing infection may require monthly treatment to break the cycle of reinfection. Topical malathion may reduce perianal itch, but must be used with care because it may also cause local irritation. Ancylostoma spp. and Necator spp. (hookworm) Hookworm is endemic in the tropics and subtropics, infecting about one billion individuals worldwide. Less than 10 cases per year are reported to the HPA, the majority in individuals from the Indian subcontinent and South-East Asia. Indiginous infection is rare in the UK. Infection is acquired by larval skin penetration from contact with faecally contaminated soil, causing a localised itchy rash. Infection by nonhuman hookworms can cause a persistent, intensely itchy serpiginous rash, known as cutaneous larva migrans (see Figure 2). Migration through the lungs can cause a more persistent pneumonitic Loeffler s Trichuris trichiura (whipworm, see Figure 3) Up to 800 million individuals, mostly school-age children, are infected worldwide, with transmission by accidental ingestion of ova. About 25 cases per year are reported to the HPA, mostly in individuals from the Indian subcontinent, sub-saharan Africa and South-east Asia; indigenous infection is uncommon. Infection is often asymptomatic but may cause abdominal cramps, diarrhoea, blood loss, rectal prolapse and malabsorption with heavy infestations. Strongyloides stercoralis Though mostly confined to the tropics and subtropics, infection is found worldwide. About 20 cases per year are diagnosed by the Hospital for Tropical Diseases, two-thirds in migrants and one-third in travellers. Initial infection is by larval skin penetration, as for hookworm. Infectious larvae are also passed in the stool and may penetrate perianal skin, so allowing persistent infection of a host despite no further exposure to contaminated soil. For this reason disease may become evident many years after leaving an endemic area. Figure 2. Cutaneous larva migrans, a skin rash caused by burrowing hookworm larvae 26 Prescriber 5 August

4 USA. About 35 cases per year are reported in the UK, the majority with a travel history to the Indian subcontinent. Bloodstream and tissue helminths It is uncommon for UK-based travellers to present with symptomatic tissue helminths, though migrants may present with unusual symptom complexes due to schistosomal or filarial disease. Figure 3. Trichuris or whipworm: treatment with mebendazole is readily available Larval migration can cause both a pulmonary eosinophilia syndrome and transient cutaneous urticarial eruptions (larva currens). Larger infection loads may cause diarrhoea, protein-losing enteropathy and oedema, while in the immunocompromised a potentially fatal hyperinfection syndrome associated with Gram-negative sepsis may occur. Most infection is asymptomatic. Taenia spp. (tapeworm, see Figure 4) Tapeworm infection is seen worldwide, wherever cattle or pigs have access to human faeces and where food controls are lax. Beef tapeworms are up to 5m in length and usually asymptomatic, coming to light when worm segments are passed in the faeces. About 40 cases per year are reported to the HPA, with about half of cases related to travel in sub-saharan Africa, especially Ethiopia. Pork tapeworm is also usually relatively asymptomatic and rarely reported in the UK. Accidental ingestion of Taenia solium eggs from infected faeces can give rise to cysticercosis, with the development of painless cutaneous and muscle nodules, myocarditis and CNS cysts. These remain asymptomatic unless causing blockage to cerebrospinal fluid flow or by causing localised inflammation when the cyst dies, which can precipitate epileptic seizures. Management of neurocysticercosis is difficult and suspected cases should be referred to regional infectious diseases or neurology units for investigation and treatment. The dwarf tapeworm, Hymenolepis nana, may be associated with diarrhoea and vague neurological syndromes including headaches, dizziness and sleep disturbance in children. Infection is found worldwide and it is probably the commonest tapeworm in the Schistosomiasis (see Figure 5) Schistosomiasis affects over 200 million worldwide and is caused by a bloodstream fluke. It is acquired through larval skin penetration while in contaminated fresh water and there are a variety of syndromes associated with infection. During the early phase of larval migration symptoms of fever, eosinophilia, urticaria and myalgia may be seen. This is named Katayama syndrome and is part of the differential diagnosis of acute fever in those returning from endemic areas. Schistosoma mansoni may cause persistent bloody diarrhoea in migrants and travellers from sub-saharan Africa. Chronic infection may lead to portal hypertension and pulmonary fibrosis. S. haematobium causes genitourinary tract pathology including haematuria, inflammatory bladder changes, genital skin lesions and alteration in semen colour and consistency. Chronic infection can cause obstructive uropathy. Figure 4. Taenia or tapeworm infection is treated with a single dose of niclosamide or praziquantel 28 Prescriber 5 August

5 In the UK a peak of about 200 cases per year was seen in the early 1990s, though this has fallen to less than a 100 per year currently. Two-thirds of cases were S. haematobium and almost two-thirds were in males aged 15-44, often associated with water exposure in Lake Malawi. Filarial disease Filarial transmission is inefficient and it is unusual for those without prolonged exposure to the vector species to acquire significant infection. Filaria may affect the lymphatics, causing episodic lymphangitis with progression to chronic lymphoedema and classical elephantiasis. Tissue filariae, such as Loa loa and Onchocerca, are rare outside endemic areas. Investigation The majority of patients with gut helminths will be either relatively asymptomatic or will present having passed a whole worm or worm segment. Identification of worms can be undertaken by local microbiology laboratories or by reference centres. Individuals with gastrointestinal symptoms or concerns following travel can be initially screened by stool examination for ova, cysts and parasites. Enterobius can be identified using the various commercially available variants of the Sellotape test to provide perianal sampling for ova. More complex investigations, such as serological testing for filaria and Strongyloides, are available but their interpretation can be complex and their use is probably best discussed with local infectious diseases or microbiology departments. Evidence for cysticercosis may be found on plain radiology of the large muscle groups, showing calcified cysticerci. Nodule and muscle biopsy may also identify the problem. Proctoscopy may be of use in identifying Trichuris. Given the sometimes complex epidemiology and presentation of the more obscure helminths it is often worth discussing cases with local infection services, or referring patients to a specialist centre for formal assessment and treatment. Treatment (see Table 3) When one individual in a family is found to be infected it may be prudent to screen other members for infection, particularly in cases such as threadworm. Patients should be advised about personal hygiene and care during food preparation, but also be reassured that, in general, transmission of most helminths within the home is difficult. Drugs for treatment of helminths may be difficult to obtain and several are available on a named-patient Figure 5. Schistosoma is a bloodstream fluke treated with two doses of praziquantel six hours apart basis only. For exotic helminth infections, referral to an infectious diseases service will probably be necessary from the point of view of accurate diagnosis, obtaining medication and for appropriate follow-up. Data on the use of all anthelmintic drugs during pregnancy and breast-feeding are limited so their use in these situations should be discussed with specialists. It is probably wiser in most situations to withhold treatment until the end of pregnancy. Most anthelmintic drugs are not licensed for use in children under two or have age-adjusted dosing regimens. Single worm infections, such as Ascaris or Enterobius, can be easily treated in the community. Mebendazole and piperazine (Pripsen) are both available in the community and should be used as first-line agents. Albendazole (named-patient only) is probably better tolerated and slightly more efficacious than mebendazole. With treatment of families, multiple infections or complex infections such as Strongyloides or schistosomiasis it is more appropriate to refer the patient to a specialist unit for treatment. Benzimidazoles are toxic to nematode cytoskeletal elements and to ova. Side-effects of mebendazole and albendazole drugs are minimal and transient and include epigastric discomfort, nausea, headache, rash and urticaria. No drug interactions have been documented but cimetidine and steroids may increase serum benzimidazole levels. Tiabendazole (named-patient only) has a similar side-effect profile to the other benzimidazoles and should be used with caution in renal and hepatic impairment. It should not be used in mixed infections involving Ascaris as Prescriber 5 August

6 Drug Organism Dosage Adults (BNF 51) Children (BNFC 2005) mebendazole* Ascaris, Trichuris, hookworm 100mg twice daily for 3 days 1-18y as adults Enterobius 100mg single dose, repeat at 6m-18y as adults 2 weeks albendazole** Ascaris, Enterobius, 400mg single dose Trichuris, hookworm cutaneous larva migrans 400mg once daily for 3 days (unlicensed use) Strongyloides 400mg once or twice daily over 2y 400mg twice daily for 3 for 3 days days Trichinella 400mg twice daily for 1 week piperazine* Ascaris 4g single dose, repeat monthly 3m-1y 2.5ml level spoon single dose up to 3m if reinfection risk 1-6y 5ml level spoon single dose 6-18y 1 sachet (4g) single dose repeat monthly for up to 3m if reinfection risk Enterobius 4g single dose, repeated at 2 first dose as for Ascaris; repeat at weeks 2 weeks ivermectin ** Strongyloides, cutaneous 200µg/kg single dose Strongyloides: over 5y 200µg/kg larva migrans once daily for 2 days niclosamide ** tapeworm 2g single dose under 2y 500mg single dose 2-6y 1g single dose 6-18y 2g single dose praziquantel** tapeworm 10-20mg/kg single dose over 4y 10-20mg/kg single dose after food Hymenolepis nana 25mg/kg single dose over 4y 25mg/kg single dose schistosomiasis 20mg/kg 2 doses, 6 hours over 4y 40mg/kg in 2 divided apart doses 4-6 hours apart; S. japonicum 60mg/kg in 3 divided doses tiabendazole** Strongyloides stercoralis 25mg/kg (max. 1.5g) every 12 over 1m as adults hours for 3 days levamisole** Ascaris mg single dose 1m-18y 2.5-3mg/kg (max. 150mg) single dose hookworm 1m-18y 2.5mg/kg (max. 150mg) single dose, repeat at 1 week if severe *available over-the-counter **available on named-patient basis only Table 3. Drugs used in the treatment of helminth infections 30 Prescriber 5 August

7 it may precipitate worm migration and consequent complications. Piperazine causes helminth muscle paralysis, possibly by competitive antagonism of acetylcholine. It is contraindicated in epilepsy as it may lower seizure threshold. There is some evidence of neurotoxicity causing ataxia, myoclonus and hypotonia. Commoner side-effects are gastrointestinal upset and urticaria. Piperazine may interact with phenothiazines, increasing extrapyramidal effects. Ivermectin (named-patient only) causes ion channel-mediated helminth muscle paralysis. Side-effects are unusual and include pruritus, oedema, rash, fever, headache and tender lymphadenopathy. Rarely orthostatic hypotension may occur. There are no documented drug interactions. Praziquantel (named-patient only) causes helminth muscle paralysis and membrane damage. It may cause abdominal discomfort, dizziness and somnolence, which is exacerbated by alcohol. Cimetidine may increase serum levels and chloroquine can reduce bioavailability. Niclosamide (named-patient only) causes adult tapeworm muscle paralysis. There are no documented drug interactions and only minimal side-effects are reported with this drug. Levamisole (named-patient only) causes helminth muscle paralysis. Nausea, gastrointestinal disturbance and mild neurological symptoms are reported. Resources Advice and referrals Department of Infection and Tropical Disease, Heartlands and Solihull Hospitals, Birmingham. Tel: School of Tropical Medicine, Liverpool. Tel: ; fax: ; website: Department of Tropical Disease, University College Hospital, London. Tel: , bleep 5845; website: Scottish Centre for Infection and Environmental Health. Tel: ; fax: ; website: Obtaining named patient-only drugs IDIS World Medicines, tel: ; website: All drugs available on a named-patient basis can be ordered via IDIS World Medicines (see Resources) with an approximate two-week waiting time. Conclusion The majority of helminth infections in the UK are relatively asymptomatic; however, they may be of relevance, particularly in migrant populations. Most can be relatively easily diagnosed by local laboratory services. Management may be better carried out by specialist units for the more complex diseases for a variety of reasons, not least that drugs may be difficult to obtain in the community. References Burkhart CN, Burkhart CG. Assessment of frequency, transmission and genitourinary complications of enterobiasis (pinworms). Int J Derm 2005;44: Unusual infections associated with foreign travel part 3: helminth infections. CDR Weekly 2004;14(23):7-9. Unusual infections associated with foreign travel part 4: helminth infections and intestinal cestodes. CDR Weekly 2004;14(41):8-11. Whetham J, Day JN, Armstrong M, et al. Investigation of tropical eosinophilia; assessing a strategy based on geographical area. J Infect 2003;46: Dr Newsholme is a consultant in infectious diseases at Hammersmith Hospitals NHS Trust, London Further reading Anthelmintics: a comparative review of their clinical pharmacology. Bundy DAP, de Silva NR. Drugs 1997; 53(5): Drug treatment of tropical parasitic infections. Recent achievements and developments. Stephenson I, Wiselka M. Drugs 2000;60: Can we deworm this wormy world? Bundy DAP, de Silva NR. British Medical Bulletin 1998;54(2): Worms and human disease. 2nd ed. Muller R. Oxford: CABI Publishing, Mebendazole, albendazole, piperazine, diethylcarbamazine, praziquantel and ivermectin. In: Dollery C, ed. Therapeutic drugs. Churchill Livingstone, Prescriber 5 August

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