MATERIAL SAFETY DATA SHEET

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1 Coulter MATERIAL SAFETY DATA SHEET Section 1 Company and Product Identification Product Name Part Number ph 4 Red Buffer Doc. ID AC Issued (year/month/day) Revised (year/month/day) 2007/07/06 Product Use Manufacturer Distributor and Emergency Phone No. ph Meter Reagent Beckman Coulter, Inc Harbor Blvd. Fullerton, CA , U.S.A. ECREP Address: Beckman Coulter Ireland, Inc. Mervue Business Park, Mervue, Galway, Ireland Refer to attached list, Document ID: , for local distributor and emergency phone numbers. Section 2 Composition and Information on Ingredients Ingredients: Meets Criteria: Chemical Name CAS # %bywt. EU US OSHA WHMIS Potassium Biphthalate <2 No Yes Yes See Section 15 Regulatory Information for additional information on hazard classifications. Emergency Overview Section 3 Hazards Identification Red; Transparent; Liquid; Odorless Nonflammable aqueous solution. Skin and eye irritant. Physical Hazards Potential Health Effects Summary No physical hazards were determined from a review of available literature. Contact with the skin or eyes may cause irritation. See Section 11 Toxicological Information for more detailed health information. Product Hazard Classifications EU: WHMIS: D2B US OSHA: Beckman Coulter Safety Rating Flammability (Section V): 0 Health (Section XI): 2 Reactivity with Water (Section X): 0 Contact (Section VIII): 2 Code 0=none 1=slight 2=caution 3=severe 2007 Beckman Coulter, Inc. Global MSDS English

2 ph 4 Red Buffer MSDS # AC Page2of5 Section 4 First Aid Measures Inhalation Eye Contact Skin Contact Ingestion If product is inhaled, move exposed individual to fresh air. If individual is not breathing, begin artificial respiration immediately and obtain medical attention. If product enters eyes, wash eyes gently under running water for 15 minutes or longer, making sure that the eyelids are held open. If pain or irritation occur, obtain medical attention. In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. If pain or irritation occur, obtain medical attention. If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical attention. Section 5 Fire Fighting Measures Flash Point Flammable Limits Autoignition Temp. Extinguishing Media Special Fire and Explosion Hazards Combustion Products Protective Equipment for Firefighters Use extinguishing media suitable for surrounding fire. No combustion products posing significant hazards are expected from this product (a dilute aqueous solution). Self-contained breathing apparatus is recommended for firefighters in all chemical fire situations. Section 6 Accidental Release Measures Personal Precautions Spill and Leak Procedures Environmental Precautions Use good laboratory procedures; avoid eye and skin contact. Absorb spilled material with an appropriate inert, non-flammable absorbent and dispose according to local regulations. Contain spill to prevent migration. Section 7 Handling and Storage Handling Precautions Recommended Storage Conditions Use good laboratory procedures; avoid eye and skin contact. Keep away from incompatible material (see Section 10). To maintain efficacy, store according to the instructions in the product labeling. Section 8 Exposure Controls and Personal Protection Exposure Limits US OSHA: ACGIH: DFG MAK:

3 ph 4 Red Buffer MSDS # AC Page3of5 Section 8 Exposure Controls and Personal Protection (Continued) Engineering Controls Respiratory Protection Eye Protection Skin Protection No special engineering controls are required. Use with good general ventilation. Under normal conditions, the use of this product should not require respiratory protection. Safety glasses or chemical goggles should be worn to prevent eye contact. Impervious gloves, such as Nitrile or equivalent, should be worn to prevent skin contact. Section 9 Physical and Chemical Properties Physical State Liquid Color Red Transparency Transparent Odor Odorless Odor Threshold ph 4 Boiling Point Melting Point Specific Gravity Vapor Pressure Vapor Density Evaporation Rate Solubility Water Organic 100 C(212 F) C Miscible Section 10 Stability and Reactivity Stability Incompatibilities Decomposition Products Conditions to Avoid Stable under normal temperatures and pressures. Strong acids Strong bases Strong oxidizers No decomposition products posing significant hazards would be expected from this product (a dilute aqueous solution). Avoid contact with incompatible materials. Section 11 Toxicological Information Toxicity Data for Ingredients Potassium Biphthalate Primary Routes of Exposure Oral LD50 Rat: >3200 mg/kg Eye contact, ingestion, inhalation, and skin contact.

4 ph 4 Red Buffer MSDS # AC Page4of5 Section 11 Toxicological Information (Continued) Potential Effects of Acute Exposure Potential Effects of Chronic Exposure Symptoms of Overexposure Carcinogenicity Other Effects Conditions Aggravated by Exposure Inhalation of potassium biphthalate dusts may cause respiratory tract irritation. Skin and eye contact may cause irritation. Ingestion of large amounts may cause irritation and some systemic effects. Repeated or prolonged exposure to potassium biphthalate by skin contact may cause dermatitis and eye contact may cause conjunctivitis. Symptoms of overexposure may include: coughing, hoarseness and wheezing when dust is inhaled. Skin contact may result in dermatitis characterized by itching, blisters, rash, soreness and cracking. Eye contact may cause redness, pain, and conjunctivitis characterized by tearing, redness, inflammation, blurred vision and possibly pus-like or watery discharge. Ingestion of large amounts may cause nausea, diarrhea and abnormal sensations in the hands and feet. No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA or 67/548/EEC Annex I. Section 12 Ecological Information Ecotoxicity Biodegradability Mobility Section 13 Disposal Considerations Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the authorities for information. Section 14 Transport Information Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG. US Federal and State Regulations Section 15 Regulatory Information SARA 313 CERCLA RG s, 40 CFR California Proposition 65 Massachusetts MSL New Jersey Dept. of Health RTK List Pennsylvania RTK

5 ph 4 Red Buffer MSDS # AC Page5of5 EU Labeling Classification Preparation not classified. Section 15 Regulatory Information (Continued) Canada WHMIS Classification: PIN: Ingredients on Ingredient Disclosure List: Ingredients with unknown toxicological properties: D2B Poisonous and Infectious Material: Division 2 Other Toxic Effects: Toxic (Chronic Toxic Effects) D2B Poisonous and Infectious Material: Division 2 Other Toxic Effects: Toxic (Eye Irritation) D2B Poisonous and Infectious Material: Division 2 Other Toxic Effects: Toxic (Skin Irritation) None None Section 16 Other Information For further information, please contact your local Beckman Coulter representative. WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS. Printed in U.S.A.

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